Hematology Panels | Mission Bio

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href="https://missionbio.com/applications/oncology/">Oncology Research</a></span> <span class="bread-arrow"></span> <span class="breadcrumb_last" aria-current="page">Hematologic Malignancies</span></span></div></div> <div class="capability-hero hematology"> <div class="_1300-container inner-content hematology"> <div class="apps-cols"> <div class="application-image hematology"></div> <div class="mission-copy"> <h1 class="h2-thin nm w">Hematology Panels </h1> <div class="panel-sub">Because single-cell insights are critical to determining the source of resistance, response, and relapse</div> <p class="mb30">The complexity of cancer is vast, and it is critical to measure the network of biological interactions accurately and minimize inferences. With Mission Bio’s hematology panels, you can simultaneously analyze DNA mutations and protein expression, to discover clonal networks otherwise obfuscated by bulk methods done in parallel. By connecting genotype to phenotype at the single-cell level, you can gain comprehensive insights into disease progression, development of resistance, and minimal residual disease (MRD).</p> <a href="/company/contact/" class="button w w-button">TALK TO A SCIENTIST</a> <p class="hero-small-copy"><strong class="highlight">NEW:</strong> Check out the latest Tapestri Platform updates.</p> <a href="https://missionbio.com/campaign/do-more-single-cell-with-less/" class="more-link show small">LEARN MORE</a> </div> </div> </div> </div> <div class="panels-categories"> <div class="_1300-container inner-content capabilities-links"> <div class="panels-links"> <a href="#Benefits" class="cap-link">KEY BENEFITS</a> <a href="#Panels" class="cap-link">PANELS</a> <a href="#Capabilities" class="cap-link">CAPABILITIES</a> <a href="#Applications" class="cap-link">OTHER APPLICATIONS</a> <a href="#Resources" class="cap-link">RESOURCES</a> </div> </div> </div> <div id="Benefits" class="panels-section st"> <div class="_1300-container inner-content key-benefits"> <h2 class="h2 c">Why Single Cell for Hematologic Malignancy Applications?</h2> <p class="mb30-copy _60">For hematologic malignancies, simultaneous DNA and protein analysis from the same cell can resolve the zygosity of mutations, determine if mutations co-occur or are mutually exclusive, and correlate that to immunophenotypes. With these insights, phylogenetic trees can be reconstructed to determine the order of acquisition of these mutations. Fish plots show how clonal architecture changes throughout the course of treatment. And monitoring during remission poses great promise for sensitive MRD detection.</p> <p class="highlight-heading">It is time to get a holistic view of cancer</p> <div class="benefits-cols mb"> <div class="benefits-card"> <div class="benefit-content bold"> <a href="/wp-content/themes/missionbio-v2/images-2/App_Heme1_PhylogeneticTree-new.png" class="panel-lightbox w-inline-block i-lightbox""> <img src="/wp-content/themes/missionbio-v2/images-2/App_Heme1_PhylogeneticTree-new-Thumb.png" alt="Track clonal evolution and reconstruct phylogenetic trees" class="app-icon" style="height: 250px; width: auto;"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <div>Track clonal evolution and reconstruct phylogenetic trees</div> <div class="illustration-note" style="font-style: normal;"> Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics <br><br> Dr. Koichi Takahashi, MD Anderson Cancer Center </div> <a href="https://missionbio.com/resources/publications/clonal-evolution-of-acute-myeloid-leukemia-revealed-by-high-throughput-single-cell-genomics/" class="view-link">VIEW PAPER</a> </div> </div> <div class="benefits-card"> <div class="benefit-content bold"> <a href="/wp-content/themes/missionbio-v2/images-2/App_Heme2_FishPlot-new.png" class="panel-lightbox w-inline-block i-lightbox""> <img src="/wp-content/themes/missionbio-v2/images-2/App_Heme2_FishPlot-new.png" alt="Reveal therapy resistance mechanisms through course of treatment" class="app-icon" style="height: 250px; width: auto;"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <div>Reveal therapy resistance mechanisms through course of treatment</div> <div class="illustration-note" style="font-style: normal;"> Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in AML <br><br> Dr. Cathy Smith, Dr. Alexander Perl, UCSF, UPenn </div> <a href="https://missionbio.com/resources/publications/clonal-selection-with-ras-pathway-activation-mediates-secondary-clinical-resistance-to-selective-flt3-inhibition-in-aml/" class="view-link">VIEW PAPER</a> </div> </div> <div class="benefits-card"> <div class="benefit-content bold"> <a href="/wp-content/themes/missionbio-v2/images-2/App_Heme3_MRD-new.png" class="panel-lightbox w-inline-block i-lightbox""> <img src="/wp-content/themes/missionbio-v2/images-2/App_Heme3_MRD-new-Thumb.png" alt="Monitor disease during remission to track MRD" class="app-icon" style="height: 250px; width: auto;"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <div>Monitor disease during remission to track MRD</div> <div class="illustration-note" style="font-style: normal;"> Single-cell mutational profiling enhances the clinical evaluation of AML MRD <br><br> Dr. Ravi Majeti, Stanford </div> <a href="https://missionbio.com/resources/publications/single-cell-mutational-profiling-enhances-the-clinical-evaluation-of-aml-mrd/" class="view-link">VIEW PAPER</a> </div> </div> </div> </div> </div> <div id="Panels" class="panels-section hema-application"> <div class="_1300-container inner-content panels-details w hem-callout"> <div class="mission-cols"> <div class="application-image hematology v2" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/products/panels/MBIO_Tapestri-Box.png);"></div> <div class="panel-col"> <h2 class="h2-thin">Hematology Panels</h2> <p class="mb30 b">Order predesigned hematology panels or customize any panel with your own targets</p> <p class="mb30">Select panel content relevant to your specific sequencing applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several catalog targeted panels based on public databases and actionable clinical targets.</p> </div> </div> <div class="available-panels"> <div class="p-available-2 l">Available DNA Hematology Panels</div> <div class="h-capabilities-col-2"> <div class="h-capabilities-sub-grid-2"> <div class="h-capabilities-sub-grid-col-2 left" data-ix="show-more-link"> <div class="ready-title">Ready-to-Ship</div> <div class="panel-sub-title l">Tapestri Single-cell DNA Catalog Panels</div> <div class="mb">Predesigned and ready-to-ship hematology panels covering the most commonly implicated genes in hematologic malignancies. Wet lab-tested to assure performance.</div> <a href="https://missionbio.com/products/panels/acute-myeloid-leukemia/" class="p-link-2 w-inline-block"> <div>Acute Myeloid Leukemia</div> </a> <a href="https://missionbio.com/products/panels/mrd-aml/" class="p-link-2 w-inline-block"> <div>MRD AML</div> </a> <a href="https://missionbio.com/products/panels/multiple-myeloma/" class="p-link-2 w-inline-block"> <div>Multiple Myeloma</div> </a> <a href="https://missionbio.com/products/panels/myeloid/" class="p-link-2 w-inline-block"> <div>Myeloid</div> </a> <div class="divider"></div> <div class="panel-sub-title l"><span class="highlight">NEW:</span> Tapestri Single-cell DNA Published Panels</div> <div class="mb">Predesigned and ready-to-ship hematology panels designed by leading researchers of hematologic malignancies. Featured in peer-reviewed publications from leading research institutes.</div> <a href="https://missionbio.com/products/panels/published-acute-lymphoblastic-leukemia/" class="p-link-2 w-inline-block"> <div>Acute Lymphoblastic Leukemia (Cools, VIB)</div> </a> <a href="https://missionbio.com/products/panels/published-chronic-lymphocytic-leukemia/" class="p-link-2 w-inline-block"> <div>Chronic Lymphocytic Leukemia (Abdel-Wahab, MSKCC)</div> </a> <a href="https://missionbio.com/products/panels/published-myeloid/" class="p-link-2 w-inline-block"> <div>Myeloid (Takahashi, MDACC)</div> </a> <a href="https://missionbio.com/products/panels/published-myeloid-clonal-evolution/" class="p-link-2 w-inline-block"> <div>Myeloid Clonal Evolution (Levine, MSKCC)</div> </a> <a href="https://missionbio.com/products/panels/published-myeloproliferative-neoplasms/" class="p-link-2 w-inline-block"> <div>Myeloproliferative Neoplasms (Blombery, Peter Mac)</div> </a> </div> <div class="h-capabilities-divider half"></div> <div class="h-capabilities-sub-grid-col-2 left" data-ix="show-more-link"> <div class="custom-title">Build-to-Order</div> <div class="panel-sub-title l">Tapestri Single-cell DNA Virtual Design Panels</div> <div class="mb">Predesigned and build-to-order panels for additional indications in hematologic malignancies.</div> <a href="https://missionbio.com/products/panels/acute-lymphoblastic-leukemia/" class="p-link-2 w-inline-block"> <div>Acute Lymphoblastic Leukemia</div> </a> <a href="https://missionbio.com/products/panels/chronic-myeloid-leukemia/" class="p-link-2 w-inline-block"> <div>Chronic Myeloid Leukemia</div> </a> <a href="https://missionbio.com/products/panels/classic-hodgkins-lymphoma/" class="p-link-2 w-inline-block"> <div>Classic Hodgkin’s Lymphoma</div> </a> <a href="https://missionbio.com/products/panels/diffuse-large-b-cell-lymphoma/" class="p-link-2 w-inline-block"> <div>Diffuse Large B-Cell Lymphoma</div> </a> <a href="https://missionbio.com/products/panels/follicular-lymphoma/" class="p-link-2 w-inline-block"> <div>Follicular Lymphoma</div> </a> <a href="https://missionbio.com/products/panels/mantle-cell-lymphoma/" class="p-link-2 w-inline-block"> <div>Mantle Cell Lymphoma</div> </a> <a href="https://missionbio.com/products/panels/myelodysplastic-syndromes/" class="p-link-2 w-inline-block"> <div>Myelodysplastic Syndromes</div> </a> <a href="https://missionbio.com/products/panels/myeloproliferative-neoplasms/" class="p-link-2 w-inline-block"> <div>Myeloproliferative Neoplasms</div> </a> <a href="https://missionbio.com/products/panels/t-cell-lymphoma/" class="p-link-2 w-inline-block"> <div>T-Cell Lymphoma</div> </a> <div class="divider"></div> <div class="panel-sub-title l">Tapestri Single-cell DNA Custom Panels</div> <div class="mb">Fully customizable hematology panels for maximum flexibility. Easily order a custom panel using Tapestri Designer.</div> <a href="https://missionbio.com/products/panels/custom-panels/" class="p-link-2 w-inline-block"> <div>Learn More</div> </a> </div> </div> </div> </div> <div class="available-panels"> <div class="p-available-2 l">Available Protein Hematology Panels</div> <div class="h-capabilities-col-2"> <div class="h-capabilities-sub-grid-2"> <div class="h-capabilities-sub-grid-col-2 left _100" data-ix="show-more-link"> <div class="mb">Concurrently measure proteins by ordering the ready-to-ship TotalSeq™-D Heme Oncology Cocktail or by configuring your own antibody cocktail from a growing catalog of pre-optimized antibody oligonucleotide conjugates.</div> <a href="https://missionbio.com/products/panels/totalseq-d-heme-oncology/" class="p-link-2 w-inline-block"> <div>TotalSeq™-D Heme Oncology Cocktail from BioLegend</div> </a> <a href="https://www.biolegend.com/en-us/search-results?PageSize=25&Format=TOTALSEQ_D" target="_blank" class="p-link-2 w-inline-block"> <div>TotalSeq™-D Catalog Antibodies from BioLegend</div> </a> </div> </div> </div> </div> </div> </div> <div id="Case-Study" class="panels-section case-study testimonial"> <div class="_1300-container inner-content panels-details"> <div class="mission-cols"> <div class="application-image case-study" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/people/ts-katherine-cummins.jpg);"> <a href="https://missionbio.wistia.com/medias/myylmo0pwk?autoplay=true" class="w-inline-block v-lightbox video-link"></a> </div> <div class="panel-col"> <img src="/wp-content/themes/missionbio-v2/images-2/logos/UPenn-white.png" alt="University of Pennsylvania" class="case-logo"> <h2 class="h2-thin w">Hear from a hematological pathologist on how single-cell multi-omics can transform cell therapies for leukemias.</h2> <p style="color: #FFF;" class="mb30">Katherine D. Cummins, MD, FRACP, FRCPA, University of Pennsylvania</p> <a href="https://missionbio.wistia.com/medias/myylmo0pwk?autoplay=true" class="button w w-button v-lightbox video-link" style="width: auto; height: auto;"> WATCH VIDEO </a> </div> </div> </div> </div> <div id="Capabilities" class="_1300-container inner-content capabilities home"> <div class="section-title-small">CAPABILITIES</div> <div class="red-devider mb"></div> <h2 class="h2">DNA Is Our Foundation</h2> <p>Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.</p> <div class="h-capabilities-grid"> <div class="h-capabilities-col"> <div class="h-capabilities-titles"><img src="/wp-content/themes/missionbio-v2/images/Icon-Genomics.svg" alt="DNA helix icon" class="icon"> <div class="h-capabilities-title">Single-cell Genomics (DNA)</div> </div> <div class="h-capabilities-sub-grid"> <div class="h-capabilities-sub-grid-col" data-ix="show-more-link"> <div class="h-capabilities-sub-grid-col-title">SNV</div> <div>Detect rare clonal populations and identify co-occurrence and zygosity.</div> <a href="/capabilities/snv/" class="more-link">LEARN MORE</a> </div> <div class="h-capabilities-divider half"></div> <div class="h-capabilities-sub-grid-col" data-ix="show-more-link"> <div class="h-capabilities-sub-grid-col-title">SNV + CNV</div> <div>Characterize genomic heterogeneity using a single comprehensive platform.</div> <a href="/capabilities/snv-cnv/" class="more-link">LEARN MORE</a> </div> </div> </div> <div class="h-capabilities-divider"></div> <div class="h-capabilities-col"> <div class="h-capabilities-titles"> <img src="/wp-content/themes/missionbio-v2/images/Icon-Multi-omics.svg" alt="Single cell icon" class="icon"> <div class="h-capabilities-title">Single-cell Multi-omics (DNA+)</div> </div> <div class="h-capabilities-sub-grid"> <div class="h-capabilities-divider half h"></div> <div class="h-capabilities-sub-grid-col" data-ix="show-more-link"> <div class="h-capabilities-sub-grid-col-title">DNA + Protein</div> <div>Gain a true multi-omics picture from genotype to phenotype.</div> <a href="/capabilities/dna-protein/" class="more-link">LEARN MORE</a> </div> </div> </div> </div> </div> <div id="Applications" class="panels-section margins gray"> <div class="_1300-container _50"> <div class="section-title-small">Other APPLICATIONS</div> <div class="red-devider mb"></div> </div> <div class="applications-cols _1300"> <a href="/applications/oncology/solid-tumors/" class="h-applications-col _50 st w-inline-block" data-ix="applications-hover"> <div class="h-application-overlay"></div> <div class="h-application-content"> <div class="h-application-title">Solid Tumors</div> <div>Profiling enables high resolution of the genomic diversity in a variety of tumor types.</div> <div class="more-link light">LEARN MORE</div> </div> </a> <a href="/applications/genome-editing/" class="h-applications-col _50 ge w-inline-block" data-ix="applications-hover"> <div class="h-application-overlay"></div> <div class="h-application-content"> <div class="h-application-title">Genome Editing</div> <div>Precision tools provide quality control, ensuring the appropriate edits are incorporated.</div> <div class="more-link light">LEARN MORE</div> </div> </a> </div> </div> <div id="Resources" class="h-resources"> <div class="_1300-container inner-content"> <h3 class="h3 w">Featured Resources</h3> <div class="h-resources-grid"> <div class="h-resource-card sp" data-ix="show-more-link"> <div class="h-resource-image sp" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/scientific-presentations-card-image-v2.png);"></div> <div class="h-resource-content"> <div class="h-resource-category d sp">Scientific Presentation</div> <a href="https://missionbio.com/resources/presentations/amp-2022-sanam-loghavi/" class="h-resource-title-link"> Molecular Analysis of Acute Myeloid Leukemia in Morphologic Remission </a> <br /> <a href="https://missionbio.com/resources/presentations/amp-2022-sanam-loghavi/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card sp" data-ix="show-more-link"> <div class="h-resource-image sp" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/scientific-presentations-card-image-v2.png);"></div> <div class="h-resource-content"> <div class="h-resource-category d sp">Scientific Presentation</div> <a href="https://missionbio.com/resources/presentations/acute-lymphoblastic-leukemia-webinar/" class="h-resource-title-link"> Clonal Heterogeneity in Acute Lymphoblastic Leukemia at Diagnosis and During Chemo Treatment </a> <br /> <a href="https://missionbio.com/resources/presentations/acute-lymphoblastic-leukemia-webinar/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card tn" data-ix="show-more-link"> <div class="h-resource-image tn" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/Cells.jpg);"></div> <div class="h-resource-content"> <div class="h-resource-category d pb">Publications</div> <a href="https://missionbio.com/resources/publications/a-phase-ib-ii-study-of-ivosidenib-with-venetoclax-%c2%b1-azacitidine-in-idh1-mutated-myeloid-malignancies/" class="h-resource-title-link"> A Phase Ib/II Study of Ivosidenib with Venetoclax ± Azacitidine in IDH1-Mutated Myeloid Malignancies </a> <br /> <a href="https://missionbio.com/resources/publications/a-phase-ib-ii-study-of-ivosidenib-with-venetoclax-%c2%b1-azacitidine-in-idh1-mutated-myeloid-malignancies/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card pub" data-ix="show-more-link"> <div class="h-resource-image pub" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/Cells.jpg);"></div> <div class="h-resource-content"> <div class="h-resource-category d pb">publication</div> <a href="https://missionbio.com/resources/publications/a-phase-ib-ii-study-of-ivosidenib-with-venetoclax-%c2%b1-azacitidine-in-idh1-mutated-myeloid-malignancies/" class="h-resource-title-link"> A Phase Ib/II Study of Ivosidenib with Venetoclax ± Azacitidine in IDH1-Mutated Myeloid Malignancies </a> <br /> <a href="https://missionbio.com/resources/publications/a-phase-ib-ii-study-of-ivosidenib-with-venetoclax-%c2%b1-azacitidine-in-idh1-mutated-myeloid-malignancies/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> </div> <a href="https://missionbio.com/resources/" class="more-link light show">ALL RESOURCES</a> </div> </div> <div class="cta red r"> <div class="_1300-container inner-content cta"> <h3 class="h3 w">Ready to learn more?</h3> <p class="mb30 w">Use Tapestri Designer to design a custom panel tailored to your needs.</p> <a href="/company/contact/" 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