Tumor Profiling | Mission Bio

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href="https://missionbio.com/applications/oncology/">Oncology Research</a></span> <span class="bread-arrow"></span> <span class="breadcrumb_last" aria-current="page">Solid Tumors</span></span></div></div> <div class="capability-hero hematology"> <div class="_1300-container inner-content hematology"> <div class="apps-cols"> <div class="application-image tumor"></div> <div class="mission-copy"> <h1 class="h2-thin nm w">Solid Tumor Profiling </h1> <div class="panel-sub">Because understanding cancer鈥檚 mechanisms and therapy resistance requires single-cell insights</div> <p class="mb30">A major challenge to combating cancer is the tumor鈥檚 inherent heterogeneity. Single-cell DNA sequencing allows you to unmask the underlying genetic diversity across cell populations and gain insights into the clonal architecture, mutation co-occurrence, and rare mutations driving tumor progression and therapy resistance.</p> <a href="/company/contact/" class="button w w-button">TALK TO A SCIENTIST</a> <p class="hero-small-copy"><strong class="highlight">NEW:</strong> Check out the latest Tapestri Platform updates for solid tumor research.</p> <a href="https://missionbio.com/campaign/solid-tumor/" class="more-link show small">LEARN MORE</a> </div> </div> </div> </div> <div class="panels-categories"> <div class="_1300-container inner-content capabilities-links"> <div class="panels-links"> <a href="#Data" class="cap-link">KEY聽BENEFITS</a> <a href="#Panels" class="cap-link">PANELS</a> <a href="#Capabilities" class="cap-link">CAPABILITIES</a> <a href="#Applications" class="cap-link">OTHER聽APPLICATIONS</a> <a href="#Resources" class="cap-link">RESOURCES</a> </div> </div> </div> <div id="Data" class="panels-section st"> <div class="_1300-container inner-content key-benefits"> <h2 class="h2 c">Why Single Cell for Solid Tumor Applications?</h2> <p class="mb30-copy _60">Single-cell DNA sequencing enables you to analyze SNVs, indels, CNVs, and LOH and unambiguously identify variant zygosity, mutational co-occurrence, and rare mutations in thousands of individual cells. With these in-depth insights, solid tumor researchers can elucidate the mechanisms of drug resistance through mutation acquisition, determine how cells transform from benign to malignant states, and reveal the genomic changes enabling cancer cells to metastasize.</p> <p class="highlight-heading">It is time to look at the sources of malignancies</p> <div class="benefits-cols mb"> <div class="benefits-card"> <div class="benefit-content bold"> <img src="/wp-content/themes/missionbio-v2/images-2/App_SolidTumor1_Body.png" alt="Track clonal evolution at different metastasis sites" class="app-icon" style="height: 200px; width: auto;"> <div>Track clonal evolution and reconstruct phylogenetic trees</div> <div class="illustration-note" style="font-style: normal;"> Single-cell DNA analysis with the Tapestri Platform and nuclei from metastatic melanoma tissue <br><br> Dr. Charlie Swanton, Francis Crick Institute </div> <a href="https://missionbio.com/resources/technical-notes/solid-tumor_application_note/" class="view-link">VIEW APP NOTE</a> </div> </div> <div class="benefits-card"> <div class="benefit-content bold"> <img src="/wp-content/themes/missionbio-v2/images-2/App_SolidTumor2_bargraph.png" alt="Uncover zygosity and co-occurence of mutations in solid tumor profiling" class="app-icon" style="height: 200px; width: auto;"> <div>Uncover zygosity and co-occurence of mutations in solid tumor profiling</div> <div class="illustration-note" style="font-style: normal;"> V211D mutation in MEK1 causes resistance to MEK inhibitors in colon cancer <br><br> Dr. Jorge S. Reis-Filho </div> <a href="https://missionbio.com/resources/publications/gao-cancer-discovery-2019/" class="view-link">VIEW PAPER</a> </div> </div> <div class="benefits-card"> <div class="benefit-content bold"> <img src="/wp-content/themes/missionbio-v2/images-2/App_SolidTumor3_CNV.png" alt="Measure gene and chromosome-level CNVs along with SNVs/indels and protein expression" class="app-icon" style="height: 200px; width: auto;"> <div>Measure gene and chromosome arm-level CNVs along with SNVs and indels</div> <div class="illustration-note" style="font-style: normal;"> Copy number variants and single nucleotide variants simultaneously detected in single cells <br><br> Dr. Charlie Swanton, Francis Crick Institute </div> <a href="https://missionbio.com/resources/technical-notes/cnv_application_note/" class="view-link">VIEW APP NOTE</a> </div> </div> </div> </div> </div> <div id="Panels" class="panels-section hema-application"> <div class="_1300-container inner-content panels-details w hem-callout"> <div class="mission-cols"> <div class="application-image hematology v2" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/products/panels/MBIO_Tapestri-Box.png);"></div> <div class="panel-col"> <h2 class="h2-thin">Solid Tumor Panels</h2> <p class="mb30 b">Order a predesigned solid tumor panel or customize any panel with your own targets of interest</p> <p class="mb30">Select panel content relevant to your specific applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. Mission Bio offers several catalog and virtual panels for solid tumor profiling that are designed based on evidence from public databases and cover some of the most clinically relevant genes.</p> </div> </div> <div class="available-panels"> <div class="p-available-2 l">Available DNA Panels</div> <div class="h-capabilities-col-2 loghter"> <div class="h-capabilities-sub-grid-2"> <div class="h-capabilities-sub-grid-col-2 left" data-ix="show-more-link"> <div class="ready-title">Ready-to-Ship</div> <div class="panel-sub-title l">Tapestri Single-cell DNA Catalog Panel</div> <div class="mb">Predesigned and ready-to-ship panels covering the most commonly implicated genes in solid tumor cancer and wet lab-tested to assure performance. </div> </div> <div class="h-capabilities-divider half"></div> <div class="h-capabilities-sub-grid-col-2 left" data-ix="show-more-link"> <div class="custom-title">Build-to-Order</div> <div class="panel-sub-title l">Tapestri Single-cell DNA Virtual Design Panels</div> <div class="mb">Predesigned and build-to-order panels for additional indications in solid tumors. </div> <a href="https://missionbio.com/products/panels/breast-cancer/" class="p-link-2 w-inline-block"> <div>Breast Cancer</div> </a> <a href="https://missionbio.com/products/panels/glioma/" class="p-link-2 w-inline-block"> <div>Glioma</div> </a> <a href="https://missionbio.com/products/panels/tumor-hotspot/" class="p-link-2 w-inline-block"> <div>Tumor Hotspot</div> </a> <div class="divider"></div> <div class="panel-sub-title l">Tapestri Single-cell DNA Custom Panels</div> <div class="mb">Fully customizable panels for maximum flexibility. Easily order a custom panel using Tapestri Designer. </div> <a href="https://missionbio.com/products/panels/custom-panels/" class="p-link-2 w-inline-block"> <div>Learn More</div> </a> </div> </div> </div> </div> </div> </div> <div id="Case-Study" class="panels-section case-study testimonial"> <div class="_1300-container inner-content panels-details"> <div class="mission-cols"> <div class="application-image case-study" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/people/ts-jorge-reis-filho.jpg);"> <a href="https://missionbio.com/resources/publications/gao-cancer-discovery-2019/" class="w-inline-block "></a> </div> <div class="panel-col"> <img src="/wp-content/themes/missionbio-v2/images-2/logos/Memorial-Sloan-Kettering-Cancer-Center.svg" alt="Memorial Sloan Kettering Cancer Center" class="case-logo"> <h2 class="h2-thin w">See how single-cell DNA sequencing uncovers resistance mechanisms for MEK and EGFR inhibitors in colon cancer.</h2> <p style="color: #FFF;" class="mb30">Jorge Reis-Filho, MD, PhD, Memorial Sloan Kettering Cancer Center</p> <a href="https://missionbio.com/resources/publications/gao-cancer-discovery-2019/" class="button w w-button " style="width: auto; height: auto;"> VIEW PUBLICATION </a> </div> </div> </div> </div> <div id="Capabilities" class="_1300-container inner-content capabilities home"> <div class="section-title-small">CAPABILITIES</div> <div class="red-devider mb"></div> <h2 class="h2">DNA Is Our Foundation</h2> <p>Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.</p> <div class="h-capabilities-grid"> <div class="h-capabilities-col"> <div class="h-capabilities-titles"><img src="/wp-content/themes/missionbio-v2/images/Icon-Genomics.svg" alt="DNA helix icon" class="icon"> <div class="h-capabilities-title">Single-cell Genomics (DNA)</div> </div> <div class="h-capabilities-sub-grid"> <div class="h-capabilities-sub-grid-col" data-ix="show-more-link"> <div class="h-capabilities-sub-grid-col-title">SNV</div> <div>Detect rare clonal populations and identify co-occurrence and zygosity.</div> <a href="/capabilities/snv/" class="more-link">LEARN聽MORE</a> </div> <div class="h-capabilities-divider half"></div> <div class="h-capabilities-sub-grid-col" data-ix="show-more-link"> <div class="h-capabilities-sub-grid-col-title">SNV + CNV</div> <div>Characterize genomic heterogeneity using a single comprehensive platform.</div> <a href="/capabilities/snv-cnv/" class="more-link">LEARN聽MORE</a> </div> </div> </div> <div class="h-capabilities-divider"></div> <div class="h-capabilities-col"> <div class="h-capabilities-titles"> <img src="/wp-content/themes/missionbio-v2/images/Icon-Multi-omics.svg" alt="Single cell icon" class="icon"> <div class="h-capabilities-title">Single-cell Multi-omics (DNA+)</div> </div> <div class="h-capabilities-sub-grid"> <div class="h-capabilities-divider half h"></div> <div class="h-capabilities-sub-grid-col" data-ix="show-more-link"> <div class="h-capabilities-sub-grid-col-title">DNA + Protein</div> <div>Gain a true multi-omics picture from genotype to phenotype.</div> <a href="/capabilities/dna-protein/" class="more-link">LEARN聽MORE</a> </div> </div> </div> </div> </div> <div id="Applications" class="panels-section margins gray"> <div class="_1300-container _50"> <div class="section-title-small">Other APPLICATIONS</div> <div class="red-devider mb"></div> </div> <div class="applications-cols _1300"> <a href="/applications/oncology/hematology/" class="h-applications-col _50 st w-inline-block" data-ix="applications-hover" style="background-image: url(/wp-content/themes/missionbio-v2/images/B-Hematology.jpg)"> <div class="h-application-overlay"></div> <div class="h-application-content"> <div class="h-application-title">Hematologic Malignancies</div> <div>Clonal evolution impacts response, resistance, relapse, and residual disease.</div> <div class="more-link light">LEARN聽MORE</div> </div> </a> <a href="/applications/genome-editing/" class="h-applications-col _50 ge w-inline-block" data-ix="applications-hover"> <div class="h-application-overlay"></div> <div class="h-application-content"> <div class="h-application-title">Genome Editing</div> <div>Precision tools provide quality control, ensuring the appropriate edits are incorporated.</div> <div class="more-link light">LEARN聽MORE</div> </div> </a> </div> </div> <div id="Resources" class="h-resources"> <div class="_1300-container inner-content"> <h3 class="h3 w">Featured Resources</h3> <div class="h-resources-grid"> <div class="h-resource-card pub" data-ix="show-more-link"> <div class="h-resource-image pub" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/Cells.jpg);"></div> <div class="h-resource-content"> <div class="h-resource-category d pb">publication</div> <a href="https://missionbio.com/resources/publications/gao-cancer-discovery-2019/" class="h-resource-title-link"> V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer. </a> <br /> <a href="https://missionbio.com/resources/publications/gao-cancer-discovery-2019/" class="more-link">LEARN聽MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card sp" data-ix="show-more-link"> <div class="h-resource-image sp" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/scientific-presentations-card-image-v2.png);"></div> <div class="h-resource-content"> <div class="h-resource-category d sp">Scientific Presentation</div> <a href="https://missionbio.com/resources/presentations/amp-2018-eastburn/" class="h-resource-title-link"> Precision sequencing with single-cell genomics: resolving heterogeneity in blood and solid tumors </a> <br /> <a href="https://missionbio.com/resources/presentations/amp-2018-eastburn/" class="more-link">LEARN聽MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card tn" data-ix="show-more-link"> <div class="h-resource-image tn" ></div> <div class="h-resource-content"> <div class="h-resource-category d tn">technical note</div> <a href="https://missionbio.com/resources/technical-notes/solid-tumor_application_note/" class="h-resource-title-link"> Single-cell DNA analysis with nuclei isolated from solid tumor tissue </a> <br /> <a href="https://missionbio.com/resources/technical-notes/solid-tumor_application_note/" class="more-link">LEARN聽MORE</a> </div> </div> <div class="h-resource-divider"></div> </div> <a href="https://missionbio.com/resources/" class="more-link light show">ALL聽RESOURCES</a> </div> </div> <div class="cta red r"> <div class="_1300-container inner-content cta"> <h3 class="h3 w">Ready to learn more?</h3> <p class="mb30 w">Use Tapestri Designer to design a custom panel tailored to your needs.</p> <a href="/company/contact/" class="button w wo r w-button">Contact US</a> </div> </div> <script 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