Genome Editing & CRISPR Validation

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aria-current="page">Genome Editing</span></span></div></div> <section id="applications-genome-hero" style="background-image: url('https://missionbio.com/wp-content/uploads/2023/09/genome-editing-hero.png')"> <div class="_1300-container inner-content"> <div class="apps-cols"> <div class="mission-copy"> <h1 class="h2-thin nm w">Simplify Your CRISPR Analysis</h1> <div class="description"><p>From gene-edited cell therapies to CRISPR-induced disease models, genome editing outcomes can be challenging to assess. Now, get the data you need, from zygosity to co-occurrence of edits and more, at single-cell resolution with Mission Bio’s end-to-end Tapestri® Genome Editing Solution. Rapidly perform CRISPR validation in your own lab – with no clonal outgrowth or bioinformatics support required.</p> <p>Now available with whole genome CNV analysis.</p> </div> <a style="color: #ffffff; margin: 30px 0 0 0; padding-top: 9px; padding-bottom: 9px;" class="button" href="/company/contact/"" target="">Talk to Scientist</a> </div> </div> </div> </section> <section id="applications-genome-panels-categories"> <div class="panels-categories"> <div class="_1300-container inner-content capabilities-links"> <div class="panels-links"> <a href="#applications-genome-single_cell" class="cap-link">KEY BENEFITS</a> <a href="#applications-genome-reports" class="cap-link">WORKFLOW</a> <a href="#applications-genome-primary_applications" class="cap-link">APPLICATIONS</a> <a href="#applications-resources" class="cap-link">RESOURCES</a> <a href="#get_started" class="cap-link">GET STARTED</a> </div> </div> </div> </section> <section id="applications-genome-single_cell"> <div class="_1300-container inner-content key-benefits"> <h2 class="section_title">Why Single Cell for Genome Editing Analysis?</h2> <div class="mb30-copy _60"><p>Genome engineering techniques, like CRISPR, result in heterogeneous editing outcomes that include variations in zygosity, off-target effects, co-occurring multiplex edits, chromosomal translocations, and changes to genome stability. Measuring these outcomes accurately cannot be done by traditional sequencing without lengthy clonal outgrowth steps and hours of computational work. With the Tapestri single-cell platform you can obtain critical genome editing measurements to validate your cell therapy or disease model.</p> </div> <div class="benefits-cols flex"> <div class="benefits-card flex_25"> <div class="benefit-info"> <img src="https://missionbio.com/wp-content/uploads/2023/09/Zygosity.svg" alt="" class="app-icon"> <h4 class="name">Zygosity</h4> </div> </div> <div class="benefits-card flex_25"> <div class="benefit-info"> <img src="https://missionbio.com/wp-content/uploads/2023/09/Intended-Targets.svg" alt="" class="app-icon"> <h4 class="name">Co-Occurrence of Intended Targets</h4> </div> </div> <div class="benefits-card flex_25"> <div class="benefit-info"> <img src="https://missionbio.com/wp-content/uploads/2023/09/On-Off-Targets.svg" alt="" class="app-icon"> <h4 class="name">Co-Occurrence of On/Off Targets</h4> </div> </div> <div class="benefits-card flex_25"> <div class="benefit-info"> <img src="https://missionbio.com/wp-content/uploads/2024/04/Why1.png" alt="" class="app-icon"> <h4 class="name">Translocations</h4> </div> </div> <div class="benefits-card flex_25"> <div class="benefit-info"> <img src="https://missionbio.com/wp-content/uploads/2024/04/WhyS2s.png" alt="" class="app-icon"> <h4 class="name">Immunophenotype</h4> </div> </div> <div class="benefits-card flex_25"> <div class="benefit-info"> <img src="https://missionbio.com/wp-content/uploads/2024/09/Group-122.svg" alt="" class="app-icon"> <h4 class="name">Genome-wide CNV</h4> </div> </div> </div> </div> </section> <section id="applications-genome-reports"> <div class="_1300-container inner-content"> <h2 class="section_title">Create Clear Reports To Easily Interpret Results</h2> <div class="reports_list-cols flex"> <div class="reports_list__item"> <a class="panel-lightbox w-inline-block i-lightbox" title="The 10 most frequent variants and the percentage of cells that contain the variant on both alleles (biallelic), one allele (monoallelic), and not at all (wild type, WT). The variant name in the format of “chromosome:position:reference bases/alternative bases” are labeled on the x-axis. For multiplex experiments, the target group may be selected from the dropdown menu in the report." href="https://missionbio.com/wp-content/uploads/2023/09/Zygosity-of-top-10-on-target-variants.png"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <div class="title_with_border"> <h4 class="title">Zygosity of On-target Edits</h4> </div> <img class="main_image" src="https://missionbio.com/wp-content/uploads/2023/09/Zygosity-of-top-10-on-target-variants.png" alt=""> <div class="description"> The 10 most frequent variants and the percentage of cells that contain the variant on both alleles (biallelic), one allele (monoallelic), and not at all (wild type, WT). The variant name in the format of “chromosome:position:reference bases/alternative bases” are labeled on the x-axis. For multiplex experiments, the target group may be selected from the dropdown menu in the report. </div> </div> <div class="reports_list__item"> <a class="panel-lightbox w-inline-block i-lightbox" title="The percentage of cells with the most frequent combinations of multiple on-target edits. Top: frequencies of cells with each combination of edits. Bottom: zygosity of each target." href="https://missionbio.com/wp-content/uploads/2023/09/image-24.jpg"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <div class="title_with_border"> <h4 class="title">Co-Occurrence of On-Target Edits</h4> </div> <img class="main_image" src="https://missionbio.com/wp-content/uploads/2023/09/image-24.jpg" alt=""> <div class="description"> The percentage of cells with the most frequent combinations of multiple on-target edits. Top: frequencies of cells with each combination of edits. Bottom: zygosity of each target. </div> </div> <div class="reports_list__item"> <a class="panel-lightbox w-inline-block i-lightbox" title="The number of cells with different combinations of edits and cell-surface protein expression. Each column represents cells with the indicated combination of edits and protein expression. Top: the number of cells with each combination. Middle: the zygosity of on-target and predicted off-target edits. Bottom: expression of cell-surface proteins." href="https://missionbio.com/wp-content/uploads/2023/09/Genome-Editing-Cell-Surface-Protein.png"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <div class="title_with_border"> <h4 class="title">Genome Editing + Cell Surface Protein</h4> </div> <img class="main_image" src="https://missionbio.com/wp-content/uploads/2023/09/Genome-Editing-Cell-Surface-Protein.png" alt=""> <div class="description"> The number of cells with different combinations of edits and cell-surface protein expression. Each column represents cells with the indicated combination of edits and protein expression. Top: the number of cells with each combination. Middle: the zygosity of on-target and predicted off-target edits. Bottom: expression of cell-surface proteins. </div> </div> <div class="reports_list__item"> <a class="panel-lightbox w-inline-block i-lightbox" title="The percentage of cells with the most frequent translocations (up to 10) in the edited sample (# cells shown on the top of each bar). Translocation junctions occur at both predicted on- and off-target editing sites." href="https://missionbio.com/wp-content/uploads/2024/04/TOP-10-TRANSLOCATIONS.jpg"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <div class="title_with_border"> <h4 class="title">Top Translocations <br><br></h4> </div> <img class="main_image" src="https://missionbio.com/wp-content/uploads/2024/04/TOP-10-TRANSLOCATIONS.jpg" alt=""> <div class="description"> The percentage of cells with the most frequent translocations (up to 10) in the edited sample (# cells shown on the top of each bar). Translocation junctions occur at both predicted on- and off-target editing sites. </div> </div> </div> <a class="button" href="/genome-integrity-assay-development/" target="">LEARN MORE ABOUT WHOLE GENOME CNV ANALYSIS</a> </div> </section> <section id="applications-genome-tapestri"> <div class="_1300-container inner-content"> <h2 class="section_title">Tapestri Genome Editing Solution</h2> <div class="subtitle">Get everything you need to conduct single-cell, multi-omic analysis of gene edits in your lab with this fully-supported, all-in-one package.</div> <div class="info"> <ul> <li>Tapestri Instrument</li> <li>DNA Core Kit (8 samples)</li> <li>Custom-Designed DNA Panel (+ Optional Protein Panel)</li> <li>Software-Based Analysis (via Portal Access or On Premise Activation)</li> <li>Optional Antibody Hashing for Sample Multiplexing</li> <li>Optional Genome-Wide CNV Panel</li> </ul> <img class="info_image" src="https://missionbio.com/wp-content/uploads/2023/09/image-12-1.png" alt=""> </div> <div class="description"> <p>Our streamlined Genome Editing workflow allows you to analyze an edited sample on the Tapestri platform, sequence the libraries on NGS, and then easily analyze the results using the Tapestri Genome Editing Software. The Solution can analyze knockouts (non-homologous end joining) and base edits.</p> <p>You can generate essential reports with no bioinformatic expertise required. You get clear representations of your data, giving you the insights you need to move forward.</p> </div> <div class="bottom_description"> <p>The National Institute of Standards and Technology (NIST) Genome Editing Consortium addresses the measurements and standards needed to increase confidence and lower the risk of utilizing genome editing technologies in research and commercial products. Mission Bio is a proud participating partner.</p> </div> <a class="button" href="/press/nist/" target="">Learn More</a> </div> <div class="_1300-container inner-content applications-genome-new_features"> <h3 class="section_subtitle">New Features:</h3> <div class="description"><ul> <li>Addition of whole-genome CNV analysis in Tapestri Genome Editing Software (additional panel required)</li> <li>Detect chromosomal translocations – confirm presence of predicted translocation sites</li> <li>Multiplex samples with antibody hashing – reduce reagents and labor while increasing sample throughput</li> </ul> </div> </div> <div class="_1300-container inner-content applications-genome-tapestri_second"> <h2 class="section_title">The Tapestri Genome Editing Workflow</h2> <div class="subtitle">The end-to-end Tapestri workflow for single-cell genome editing analysis. A sample of gene-edited cells are processed on the Tapestri Platform, sequenced using NGS, and analyzed using Tapestri Genome Editing software. The assessment at single-cell resolution of on-targets, predicted off-targets, zygosity of edits, co-occurring (multiplex) edits, predicted translocations, cell-surface proteins, and genome integrity is possible. The Solution can be used to analyze gene knockouts (via non- homologous end joining) and base edits.</div> <div class="info"> <ul> <li>Step 1 – Design Panel & Run Edited Samples on Tapestri®</li> <li>Step 2 – Sequence Libraries on NGS</li> <li>Step 3 – Software Runs Automated Analysis and Generates Intuitive Data Report</li> </ul> <div class="zoom_image_block"> <a class="panel-lightbox w-inline-block i-lightbox" href="https://missionbio.com/wp-content/uploads/2024/04/MBIO_GenomeEditing_SchematicUpdate-REV-Whitebg.png"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <div class="zoom_image_div"> <h4></h4> <img style="width: 100%" class="info_image" src="https://missionbio.com/wp-content/uploads/2024/04/MBIO_GenomeEditing_SchematicUpdate-REV-Whitebg.png" alt=""> </div> </div> </div> <div class="description"> </div> <div class="bottom_description"> <p>Effortlessly analyze on- and off-target edits, assess zygosity, predicted translocations, co-occurring edits, and genome-wide copy number variations. Our automated analysis and intuitive reports make the process easy and efficient.</p> </div> <a style=" width: max-content; max-width: max-content;" class="button" href="/company/contact/" target="">CONTACT US TO ELEVATE YOUR CRISPR EXPERIMENTS TODAY!</a> </div> </section> <section id="applications-genome-primary_applications"> <div class="_1300-container inner-content key-benefits"> <h2 class="section_title">Primary Applications</h2> <div class="applications-cols"> <div class="applications-card" style="background-image: url('https://missionbio.com/wp-content/uploads/2023/09/Rectangle-37.jpg')"> <div class="applications-info">  <h4 class="name">Characterization of Cell-Based Therapeutics</h4> <div class="description"><ul> <li>Gather indicators of CGT safety and efficacy</li> <li>Analyze increasingly sophisticated therapies, involving multiplex edits</li> <li>Obtain IND-enabling data</li> <li>Consolidate assays, saving time and sample volumes</li> </ul> </div> <a class="button" href="/resources/technical-notes/cell-gene-therapy-genome-editing/" target=""">READ TECHNICAL NOTE</a> </div> </div> <div class="applications-card" style="background-image: url('https://missionbio.com/wp-content/uploads/2023/09/Rectangle-117.png')"> <div class="applications-info">  <h4 class="name">Validation of Disease Models</h4> <div class="description"><ul> <li>Validate CRISPR-induced disease models</li> <li>Resolve mutational co-occurrence patterns in models</li> <li>Identify genetic drivers of diseases over time</li> <li>Self-generate reports with a single end-to-end solution</li> </ul> </div> <a class="button" href="/resources/technical-notes/single-cell-dna-analysis-ael-crispr-mouse-model/" target=""">READ TECHNICAL NOTE</a> </div> </div> <div class="applications-card" style="background-image: url('https://missionbio.com/wp-content/uploads/2023/09/Rectangle-117.png')"> <div class="applications-info">  <h4 class="name">Functional Genomics</h4> <div class="description"><ul> <li>Conduct drug target validation</li> <li>Identify base changes that confer drug resistance/sensitivity</li> <li>Resolve genotypes from pooled CRISPR screens</li> <li>Interrogate non-coding regions and VUS (variants of unknown significance)</li> </ul> </div> <a class="button" href="/resources/publications/base-editing-ifny/" target=""">Read Publication</a> </div> </div> </div> </div> </section> <div id="Case-Study" class="panels-section case-study testimonial"> <div class="_1300-container inner-content panels-details"> <div class="mission-cols"> <div class="application-image case-study" style="background-image: url(https://missionbio.com/wp-content/uploads/2023/09/gill20acc20201921140x1127300x400.jpg);"> </div> <div class="panel-col"> <h2 class="h2-thin w">"This multi-omic genome-editing solution will enable critical insights for gene-edited cell therapies beyond what conventional bulk analysis can offer. The automated report gives an immediate and intuitive first look at our data, something that would usually require hours of bioinformatic labor. All in all, we are better equipped to understand our editing results with this technology."</h2> <p style="color: #FFF;" class="mb30">Saar Gill MD, PhD, Associate Professor of Medicine at the University of Pennsylvania</p> </div> </div> </div> </div> <div class="panels-section st" style="background-color: #eee;"> <div id="Start" class="_1300-container inner-content gs"> <h2 class="h2 c">Get Started</h2> <div class="contact-form-info"> <h3 class="h3 c"><p style="font-size: 36px;">Contact us to discuss your project:</p> <p style="font-size: 18px; font-weight: 400; margin: 0 0 0 0;">Fill out the form below and somebody from our team will get back to you within 2 business days.</p> </h3> <div class="contact-form-block centered w-form"> <p><iframe id="sizetracker" style="border: none; height: 800px;" src="https://go.missionbio.com/l/552252/2024-02-27/nkdp35" width="100%" scrolling="no"></iframe></p> </div> </div> </div> </div> <section id="applications-resources" class="h-resources" style=""> <div class="_1300-container inner-content"> <h2 class="section_title w" style="">Resources</h2> <div class="h-resources-grid"> <div class="h-resource-card tn" data-ix="show-more-link"> <div class="h-resource-image tn" ></div> <div class="h-resource-content"> <div class="h-resource-category d tn">technical_notes</div> <a href="https://missionbio.com/resources/technical-notes/mouse-genome/" class="h-resource-title-link"> Single-cell analysis of mouse organoid models for preclinical oncology research </a> <br/> <a href="https://missionbio.com/resources/technical-notes/mouse-genome/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card tn" data-ix="show-more-link"> <div class="h-resource-image tn" ></div> <div class="h-resource-content"> <div class="h-resource-category d tn">technical_notes</div> <a href="https://missionbio.com/resources/technical-notes/crispr_application_note/" class="h-resource-title-link"> Measuring the efficiency of CRISPR genome-editing systems using the Tapestri Platform and Tapestri Single-cell DNA Custom Panels </a> <br/> <a href="https://missionbio.com/resources/technical-notes/crispr_application_note/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card b" data-ix="show-more-link"> <div class="h-resource-image b" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/brochures.jpg);"></div> <div class="h-resource-content"> <div class="h-resource-category d br">brochures</div> <a href="https://missionbio.com/resources/brochures/dna-custom-panels-flyer/" class="h-resource-title-link"> Tapestri Single-cell DNA Custom Panels </a> <br/> <a href="https://missionbio.com/resources/brochures/dna-custom-panels-flyer/" class="more-link">LEARN MORE</a> </div> </div> </div> </div> </section> <section id="get_started"> <div class="cta red r"> <div class="_1300-container inner-content cta"> <h3 class="h3 w">Get 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