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id="toc-Adverse_effects-sublist" class="vector-toc-list"> <li id="toc-Allergy" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Allergy"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Allergy</span> </div> </a> <ul id="toc-Allergy-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Heart_attack_and_stroke" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Heart_attack_and_stroke"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Heart attack and stroke</span> </div> </a> <ul id="toc-Heart_attack_and_stroke-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Drug_interactions" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Drug_interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.3</span> <span>Drug interactions</span> </div> </a> <ul id="toc-Drug_interactions-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Mechanism_of_action" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Mechanism_of_action"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Mechanism of action</span> </div> </a> <button aria-controls="toc-Mechanism_of_action-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Mechanism of action subsection</span> </button> <ul id="toc-Mechanism_of_action-sublist" class="vector-toc-list"> <li id="toc-Anti-inflammatory" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Anti-inflammatory"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Anti-inflammatory</span> </div> </a> <ul id="toc-Anti-inflammatory-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Anti-cancer" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Anti-cancer"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Anti-cancer</span> </div> </a> <ul id="toc-Anti-cancer-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Structure-activity_relationship" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Structure-activity_relationship"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Structure-activity relationship</span> </div> </a> <ul id="toc-Structure-activity_relationship-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-History" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#History"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>History</span> </div> </a> <ul id="toc-History-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Society_and_culture" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Society_and_culture"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Society and culture</span> </div> </a> <button aria-controls="toc-Society_and_culture-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Society and culture subsection</span> </button> <ul id="toc-Society_and_culture-sublist" class="vector-toc-list"> <li id="toc-Fabricated_efficacy_studies" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Fabricated_efficacy_studies"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>Fabricated efficacy studies</span> </div> </a> <ul id="toc-Fabricated_efficacy_studies-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Brand_names" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Brand_names"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2</span> <span>Brand names</span> </div> </a> <ul id="toc-Brand_names-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Research" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Research"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Research</span> </div> </a> <button aria-controls="toc-Research-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Research subsection</span> </button> <ul id="toc-Research-sublist" class="vector-toc-list"> <li id="toc-Psychiatry" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Psychiatry"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.1</span> <span>Psychiatry</span> </div> </a> <ul id="toc-Psychiatry-sublist" class="vector-toc-list"> <li id="toc-Bipolar_disorder" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Bipolar_disorder"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.1.1</span> <span>Bipolar disorder</span> </div> </a> <ul id="toc-Bipolar_disorder-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Familial_adenomatous_polyposis_2" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Familial_adenomatous_polyposis_2"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.2</span> <span>Familial adenomatous polyposis</span> </div> </a> <ul id="toc-Familial_adenomatous_polyposis_2-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Cancer_prevention" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cancer_prevention"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.3</span> <span>Cancer prevention</span> </div> </a> <ul id="toc-Cancer_prevention-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Cancer_treatment" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cancer_treatment"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.4</span> <span>Cancer treatment</span> </div> </a> <ul id="toc-Cancer_treatment-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Celecoxib</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" 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Available in 32 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-32" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">32 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%B3%D9%8A%D9%84%D9%8A%D9%83%D9%88%D9%83%D8%B3%D9%8A%D8%A8" title="سيليكوكسيب – Arabic" lang="ar" hreflang="ar" data-title="سيليكوكسيب" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%B3%D9%84%DA%A9%D9%88%DA%A9%D8%B3%DB%8C%D8%A8" title="سلکوکسیب – South Azerbaijani" lang="azb" hreflang="azb" data-title="سلکوکسیب" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Celecocsib" title="Celecocsib – Welsh" lang="cy" hreflang="cy" data-title="Celecocsib" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Celecoxib" title="Celecoxib – German" lang="de" hreflang="de" data-title="Celecoxib" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%A3%CE%B5%CE%BB%CE%B5%CE%BA%CE%BF%CE%BE%CE%AF%CE%BC%CF%80%CE%B7" title="Σελεκοξίμπη – Greek" lang="el" hreflang="el" data-title="Σελεκοξίμπη" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Celecoxib" title="Celecoxib – Spanish" lang="es" hreflang="es" data-title="Celecoxib" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%B3%D9%84%DA%A9%D9%88%DA%A9%D8%B3%DB%8C%D8%A8" title="سلکوکسیب – Persian" lang="fa" hreflang="fa" data-title="سلکوکسیب" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/C%C3%A9l%C3%A9coxib" title="Célécoxib – French" lang="fr" hreflang="fr" data-title="Célécoxib" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%84%B8%EB%A0%88%EC%BD%95%EC%8B%9C%EB%B8%8C" title="세레콕시브 – Korean" lang="ko" hreflang="ko" data-title="세레콕시브" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Selekoksib" title="Selekoksib – Indonesian" lang="id" hreflang="id" data-title="Selekoksib" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Celecoxib" title="Celecoxib – Italian" lang="it" hreflang="it" data-title="Celecoxib" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%A1%D7%9C%D7%A7%D7%95%D7%A7%D7%A1%D7%99%D7%91" title="סלקוקסיב – Hebrew" lang="he" hreflang="he" data-title="סלקוקסיב" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Celekoxib" title="Celekoxib – Hungarian" lang="hu" hreflang="hu" data-title="Celekoxib" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%A6%D0%B5%D0%BB%D0%B5%D0%BA%D0%BE%D0%BA%D1%81%D0%B8%D0%B1" title="Целекоксиб – Macedonian" lang="mk" hreflang="mk" data-title="Целекоксиб" data-language-autonym="Македонски" data-language-local-name="Macedonian" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Celecoxib" title="Celecoxib – Dutch" lang="nl" hreflang="nl" data-title="Celecoxib" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%BB%E3%83%AC%E3%82%B3%E3%82%AD%E3%82%B7%E3%83%96" title="セレコキシブ – Japanese" lang="ja" hreflang="ja" data-title="セレコキシブ" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Celekoksib" title="Celekoksib – Norwegian Bokmål" lang="nb" hreflang="nb" data-title="Celekoksib" data-language-autonym="Norsk bokmål" data-language-local-name="Norwegian Bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%B8%E0%AD%87%E0%AC%B2%E0%AD%87%E0%AC%95%E0%AC%95%E0%AD%8D%E0%AC%B8%E0%AC%BF%E0%AC%AC" title="ସେଲେକକ୍ସିବ – Odia" lang="or" hreflang="or" data-title="ସେଲେକକ୍ସିବ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Celekoksyb" title="Celekoksyb – Polish" lang="pl" hreflang="pl" data-title="Celekoksyb" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Celecoxibe" title="Celecoxibe – Portuguese" lang="pt" hreflang="pt" data-title="Celecoxibe" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Celecoxib" title="Celecoxib – Romanian" lang="ro" hreflang="ro" data-title="Celecoxib" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A6%D0%B5%D0%BB%D0%B5%D0%BA%D0%BE%D0%BA%D1%81%D0%B8%D0%B1" title="Целекоксиб – Russian" lang="ru" hreflang="ru" data-title="Целекоксиб" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Celekoksib" title="Celekoksib – Slovenian" lang="sl" hreflang="sl" data-title="Celekoksib" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Celekoksib" title="Celekoksib – Serbian" lang="sr" hreflang="sr" data-title="Celekoksib" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Celekoksib" title="Celekoksib – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Celekoksib" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Selekoksibi" title="Selekoksibi – Finnish" lang="fi" hreflang="fi" data-title="Selekoksibi" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Celecoxib" title="Celecoxib – Swedish" lang="sv" hreflang="sv" data-title="Celecoxib" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%8B%E0%B8%B5%E0%B8%A5%E0%B8%B5%E0%B8%84%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%9A" title="ซีลีคอกซิบ – Thai" lang="th" hreflang="th" data-title="ซีลีคอกซิบ" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Selekoksib" title="Selekoksib – Turkish" lang="tr" hreflang="tr" data-title="Selekoksib" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A6%D0%B5%D0%BB%D0%B5%D0%BA%D0%BE%D0%BA%D1%81%D0%B8%D0%B1" title="Целекоксиб – Ukrainian" lang="uk" hreflang="uk" data-title="Целекоксиб" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Celecoxib" title="Celecoxib – Vietnamese" lang="vi" hreflang="vi" data-title="Celecoxib" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%A1%9E%E6%9D%A5%E6%98%94%E5%B8%83" title="塞来昔布 – Chinese" lang="zh" hreflang="zh" data-title="塞来昔布" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q408801#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet 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<div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Nonsteroidal anti-inflammatory medication</div> <p class="mw-empty-elt"> </p> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Pharmaceutical compound</div> <style data-mw-deduplicate="TemplateStyles:r1269284339">@media screen{html.skin-theme-clientpref-night .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}</style> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Celecoxib">Celecoxib</span></caption><tbody><tr><td colspan="2" class="infobox-image"><span class="skin-invert-image" typeof="mw:File"><a href="/wiki/File:Celecoxib.svg" class="mw-file-description"><img alt="Skeletal formula of celecoxib" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Celecoxib.svg/220px-Celecoxib.svg.png" decoding="async" width="220" height="191" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Celecoxib.svg/330px-Celecoxib.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Celecoxib.svg/440px-Celecoxib.svg.png 2x" data-file-width="512" data-file-height="444" /></a></span></td></tr><tr><td colspan="2" class="infobox-image"><span class="bg-transparent" typeof="mw:File"><a href="/wiki/File:Celecoxib-3D-spacefill.png" class="mw-file-description"><img alt="Space-filling model of the celecoxib molecule" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Celecoxib-3D-spacefill.png/220px-Celecoxib-3D-spacefill.png" decoding="async" width="220" height="212" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Celecoxib-3D-spacefill.png/330px-Celecoxib-3D-spacefill.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/08/Celecoxib-3D-spacefill.png/440px-Celecoxib-3D-spacefill.png 2x" data-file-width="2000" data-file-height="1930" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Pronunciation</th><td class="infobox-data"><span class="rt-commentedText nowrap"><span class="IPA nopopups noexcerpt" lang="en-fonipa"><a href="/wiki/Help:IPA/English" title="Help:IPA/English">/<span style="border-bottom:1px dotted"><span title="'s' in 'sigh'">s</span><span title="/ɛ/: 'e' in 'dress'">ɛ</span><span title="'l' in 'lie'">l</span><span title="/ɪ/: 'i' in 'kit'">ɪ</span><span title="/ˈ/: primary stress follows">ˈ</span><span title="'k' in 'kind'">k</span><span title="/ɒ/: 'o' in 'body'">ɒ</span><span title="'k' in 'kind'">k</span><span title="'s' in 'sigh'">s</span><span title="/ɪ/: 'i' in 'kit'">ɪ</span><span title="'b' in 'buy'">b</span></span>/</a></span></span> <a href="/wiki/Help:Pronunciation_respelling_key" title="Help:Pronunciation respelling key"><i title="English pronunciation respelling"><span style="font-size:90%">SEL</span>-i-<span style="font-size:90%">KOK</span>-sib</i></a> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Celebrex, Onsenal, Elyxyb, others</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/celecoxib.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a699022.html">a699022</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Celecoxib">Celecoxib</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy<br />category</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> B3<sup id="cite_ref-Drugs.com_pregnancy_1-0" class="reference"><a href="#cite_note-Drugs.com_pregnancy-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Oral_administration" title="Oral administration">By mouth</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_class" title="Drug class">Drug class</a></th><td class="infobox-data"><a href="/wiki/COX-2_inhibitor" class="mw-redirect" title="COX-2 inhibitor">Cyclooxygenase-2 (COX-2) inhibitor</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_L01" title="ATC code L01">L01XX33</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=L01XX33">WHO</a></span>) <a href="/wiki/ATC_code_M01" title="ATC code M01">M01AH01</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=M01AH01">WHO</a></span>)</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> <a href="/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons#Schedule_4" title="Standard for the Uniform Scheduling of Medicines and Poisons">S4</a> (Prescription only)</li> <li><small><abbr class="country-name" title="Brazil">BR</abbr>:</small> <a href="/wiki/Brazilian_Controlled_Drugs_and_Substances_Act#Class_C1" title="Brazilian Controlled Drugs and Substances Act">Class C1</a> (Other controlled substances)<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="/wiki/Prescription_drug" title="Prescription drug"> ℞-only</a></li> <li><small><abbr class="country-name" title="New Zealand">NZ</abbr></small>: Prescription only</li> <li><small><abbr class="country-name" title="United Kingdom">UK</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">POM</a> (Prescription only)<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Boxed_warning" title="Boxed warning"><span style="border:thin solid black;">WARNING</span></a><sup id="cite_ref-FDA-AllBoxedWarnings_2-0" class="reference"><a href="#cite_note-FDA-AllBoxedWarnings-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>Rx-only<sup id="cite_ref-Celebrex_FDA_label_5-0" class="reference"><a href="#cite_note-Celebrex_FDA_label-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></li> <li>In general: ℞ (Prescription only)</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Bioavailability" title="Bioavailability">Bioavailability</a></th><td class="infobox-data">Unknown<sup id="cite_ref-drugs_6-0" class="reference"><a href="#cite_note-drugs-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Plasma_protein_binding" title="Plasma protein binding">Protein binding</a></th><td class="infobox-data">97% (mainly to <a href="/wiki/Serum_albumin" title="Serum albumin">serum albumin</a>)<sup id="cite_ref-drugs_6-1" class="reference"><a href="#cite_note-drugs-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_metabolism" title="Drug metabolism">Metabolism</a></th><td class="infobox-data">Liver (mainly <a href="/wiki/CYP2C9" title="CYP2C9">CYP2C9</a>)<sup id="cite_ref-drugs_6-4" class="reference"><a href="#cite_note-drugs-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">7.8 hours; 11 hours (mild hepatic impairment); 13 hours (moderate-severe hepatic impairment)<sup id="cite_ref-drugs_6-2" class="reference"><a href="#cite_note-drugs-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Excretion" title="Excretion">Excretion</a></th><td class="infobox-data">Faeces (57%), urine (27%)<sup id="cite_ref-drugs_6-3" class="reference"><a href="#cite_note-drugs-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">4-[5-(4-Methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=169590-42-5">169590-42-5</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/2662">2662</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Guide_to_Pharmacology" title="Guide to Pharmacology">IUPHAR/BPS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2892">2892</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00482">DB00482</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.2562.html">2562</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/JCX84Q7J1L">JCX84Q7J1L</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D00567">D00567</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:41423">CHEBI:41423</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL118">ChEMBL118</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB ligand</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li>CEL (<span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe-srv/PDBeXplore/ligand/?ligand=CEL">PDBe</a></span>, <span title="www.rcsb.org"><a rel="nofollow" class="external text" href="https://www.rcsb.org/ligand/CEL">RCSB PDB</a></span>)</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID0022777">DTXSID0022777</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q408801#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.211.644">100.211.644</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q408801#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>17</sub><span title="Hydrogen">H</span><sub>14</sub><span title="Fluorine">F</span><sub>3</sub><span title="Nitrogen">N</span><sub>3</sub><span title="Oxygen">O</span><sub>2</sub><span title="Sulfur">S</span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002381370000000000♠"></span>381.37</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=c1cc%28C%29ccc1c2cc%28C%28F%29%28F%29F%29nn2c3ccc%28cc3%29S%28%3DO%29%28%3DO%29N">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">c1cc(C)ccc1c2cc(C(F)(F)F)nn2c3ccc(cc3)S(=O)(=O)N</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:RZEKVGVHFLEQIL-UHFFFAOYSA-N<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=458612013&page2=Celecoxib">(verify)</a></span></span></td></tr></tbody></table> <p><b>Celecoxib</b>, sold under the brand name <b>Celebrex</b> among others, is a <a href="/wiki/COX-2_inhibitor" class="mw-redirect" title="COX-2 inhibitor">COX-2 inhibitor</a> and <a href="/wiki/Nonsteroidal_anti-inflammatory_drug" title="Nonsteroidal anti-inflammatory drug">nonsteroidal anti-inflammatory drug</a> (NSAID).<sup id="cite_ref-AHFS2019_7-0" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It is used to treat the <a href="/wiki/Pain" title="Pain">pain</a> and <a href="/wiki/Inflammation" title="Inflammation">inflammation</a> in <a href="/wiki/Osteoarthritis" title="Osteoarthritis">osteoarthritis</a>, <a href="/wiki/Acute_pain" class="mw-redirect" title="Acute pain">acute pain</a> in adults, <a href="/wiki/Rheumatoid_arthritis" title="Rheumatoid arthritis">rheumatoid arthritis</a>, <a href="/wiki/Psoriatic_arthritis" title="Psoriatic arthritis">psoriatic arthritis</a>, <a href="/wiki/Ankylosing_spondylitis" title="Ankylosing spondylitis">ankylosing spondylitis</a>, <a href="/wiki/Painful_menstruation" class="mw-redirect" title="Painful menstruation">painful menstruation</a>, and <a href="/wiki/Juvenile_rheumatoid_arthritis" class="mw-redirect" title="Juvenile rheumatoid arthritis">juvenile rheumatoid arthritis</a>.<sup id="cite_ref-AHFS2019_7-1" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It may also be used to decrease the risk of <a href="/wiki/Colorectal_adenoma" title="Colorectal adenoma">colorectal adenomas</a> in people with <a href="/wiki/Familial_adenomatous_polyposis" title="Familial adenomatous polyposis">familial adenomatous polyposis</a>.<sup id="cite_ref-AHFS2019_7-2" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It is taken <a href="/wiki/Oral_administration" title="Oral administration">by mouth</a>.<sup id="cite_ref-AHFS2019_7-3" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Benefits are typically seen within an hour.<sup id="cite_ref-AHFS2019_7-4" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Common side effects include <a href="/wiki/Abdominal_pain" title="Abdominal pain">abdominal pain</a>, nausea, and <a href="/wiki/Diarrhea" title="Diarrhea">diarrhea</a>.<sup id="cite_ref-AHFS2019_7-5" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Serious side effects may include <a href="/wiki/Myocardial_infarction" title="Myocardial infarction">heart attacks</a>, <a href="/wiki/Stroke" title="Stroke">strokes</a>, <a href="/wiki/Gastrointestinal_perforation" title="Gastrointestinal perforation">gastrointestinal perforation</a>, <a href="/wiki/Gastrointestinal_bleeding" title="Gastrointestinal bleeding">gastrointestinal bleeding</a>, <a href="/wiki/Kidney_failure" title="Kidney failure">kidney failure</a>, and <a href="/wiki/Anaphylaxis" title="Anaphylaxis">anaphylaxis</a>.<sup id="cite_ref-Coxib2013_8-0" class="reference"><a href="#cite_note-Coxib2013-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AHFS2019_7-6" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Use is not recommended in people at high risk for heart disease.<sup id="cite_ref-AHA2007_9-0" class="reference"><a href="#cite_note-AHA2007-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Consumer2012_10-0" class="reference"><a href="#cite_note-Consumer2012-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The risks are similar to other NSAIDs, such as <a href="/wiki/Ibuprofen" title="Ibuprofen">ibuprofen</a> and <a href="/wiki/Naproxen" title="Naproxen">naproxen</a>.<sup id="cite_ref-NPR2018_11-0" class="reference"><a href="#cite_note-NPR2018-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Use in the later part of <a href="/wiki/Pregnancy" title="Pregnancy">pregnancy</a> or during <a href="/wiki/Breastfeeding" title="Breastfeeding">breastfeeding</a> is not recommended.<sup id="cite_ref-AHFS2019_7-7" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Drugs.com_pregnancy_1-1" class="reference"><a href="#cite_note-Drugs.com_pregnancy-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>Celecoxib was patented in 1993 and came into medical use in 1999.<sup id="cite_ref-Fis2006_12-0" class="reference"><a href="#cite_note-Fis2006-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> It is available as a <a href="/wiki/Generic_medication" class="mw-redirect" title="Generic medication">generic medication</a>.<sup id="cite_ref-BNF76_13-0" class="reference"><a href="#cite_note-BNF76-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> In 2022, it was the 93rd most commonly prescribed medication in the United States, with more than 7<span class="nowrap"> </span>million prescriptions.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Celecoxib is indicated for the treatment of <a href="/wiki/Osteoarthritis" title="Osteoarthritis">osteoarthritis</a>, <a href="/wiki/Rheumatoid_arthritis" title="Rheumatoid arthritis">rheumatoid arthritis</a>, <a href="/wiki/Psoriatic_arthritis" title="Psoriatic arthritis">psoriatic arthritis</a>, <a href="/wiki/Acute_pain" class="mw-redirect" title="Acute pain">acute pain</a>, <a href="/wiki/Musculoskeletal_pain" class="mw-redirect" title="Musculoskeletal pain">musculoskeletal pain</a>, painful <a href="/wiki/Menstruation" title="Menstruation">menstruation</a>, <a href="/wiki/Ankylosing_spondylitis" title="Ankylosing spondylitis">ankylosing spondylitis</a>, <a href="/wiki/Juvenile_rheumatoid_arthritis" class="mw-redirect" title="Juvenile rheumatoid arthritis">juvenile rheumatoid arthritis</a>, and to reduce the number of colon and rectal polyps in people with <a href="/wiki/Familial_adenomatous_polyposis" title="Familial adenomatous polyposis">familial adenomatous polyposis</a>.<sup id="cite_ref-AHFS2019_7-8" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It may be used in children with <a href="/wiki/Juvenile_rheumatoid_arthritis" class="mw-redirect" title="Juvenile rheumatoid arthritis">juvenile rheumatoid arthritis</a> who are older than two years of age and weigh more than 10 kg (22 lb).<sup id="cite_ref-AHFS2019_7-9" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>For postoperative pain, it is more or less equal to <a href="/wiki/Ibuprofen" title="Ibuprofen">ibuprofen</a>.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> For pain relief, it is similar to <a href="/wiki/Paracetamol" title="Paracetamol">paracetamol</a> (acetaminophen) at 3990 mg per day,<sup id="cite_ref-Yelland_17-0" class="reference"><a href="#cite_note-Yelland-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> which is the first line treatment for osteoarthritis.<sup id="cite_ref-OARSI2007_18-0" class="reference"><a href="#cite_note-OARSI2007-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p><p>Evidence of effects is not clear as several studies done by the manufacturer have not been released for independent analysis.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Familial_adenomatous_polyposis">Familial adenomatous polyposis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=2" title="Edit section: Familial adenomatous polyposis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>It has been used to reduce colon and rectal polyps in people with familial adenomatous polyposis, but it is not known if it decreases rates of <a href="/wiki/Cancer" title="Cancer">cancer</a>,<sup id="cite_ref-AHFS2019_7-10" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> so it is not a good choice for this reason.<sup id="cite_ref-AHFS2019_7-11" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Adverse_effects">Adverse effects</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=3" title="Edit section: Adverse effects"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Cardiovascular events: NSAIDs are associated with an increased risk of serious (and potentially fatal) adverse cardiovascular thrombotic events, including myocardial infarction and stroke. Risk may be increased with duration of use or pre-existing cardiovascular risk factors or disease. Individual cardiovascular risk profiles should be evaluated before prescribing. New-onset <a href="/wiki/Hypertension" title="Hypertension">hypertension</a> or exacerbation of <a href="/wiki/Hypertension" title="Hypertension">hypertension</a> may occur (NSAIDs may impair response to thiazide or loop diuretics), and may contribute to cardiovascular events; monitor blood pressure and use with caution in patients with hypertension. Celecoxib may cause sodium and fluid retention, so its use in patients with edema or heart failure warrants caution. Long-term cardiovascular risk in children has not been evaluated. Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce the risk of cardiovascular events; alternative therapies should be considered for patients at high risk.<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> The increased risk is about 37%.<sup id="cite_ref-Coxib2013_8-1" class="reference"><a href="#cite_note-Coxib2013-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li>Gastrointestinal events: NSAIDs may increase the risk of serious gastrointestinal (GI) ulceration, bleeding, and perforation (may be fatal). These events may occur at any time during therapy and without warning. Use caution with a history of GI disease (bleeding or ulcers), concurrent therapy with aspirin, anticoagulants and/or corticosteroids, smoking, use of <a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">alcohol</a>, and the elderly or debilitated patients. Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce the risk of GI adverse events; alternate therapies should be considered for patients at high risk. When used concomitantly with ≤325 mg of aspirin, a substantial increase in the risk of gastrointestinal complications (e.g., ulcer) occurs; concomitant gastroprotective therapy (e.g., proton pump inhibitors) is recommended.<sup id="cite_ref-Celebrex_FDA_label_5-1" class="reference"><a href="#cite_note-Celebrex_FDA_label-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The increased risk is about 81%.<sup id="cite_ref-Coxib2013_8-2" class="reference"><a href="#cite_note-Coxib2013-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li>Hematologic effects: Anemia may occur; monitor hemoglobin or hematocrit in people on long-term treatment. Celecoxib does not usually affect <a href="/wiki/Prothrombin_time" title="Prothrombin time">prothrombin time</a>, <a href="/wiki/Partial_thromboplastin_time" title="Partial thromboplastin time">partial thromboplastin time</a>, or <a href="/wiki/Platelet" title="Platelet">platelet</a> counts; it does not inhibit platelet aggregation at approved doses.</li></ul> <p>People with a prior history of ulcer disease or GI bleeding require special precautions. Moderate to severe liver impairment or GI toxicity can occur with or without warning symptoms in people treated with NSAIDs. </p><p>In October 2020, the U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) required the <a href="/wiki/Drug_labelling" title="Drug labelling">drug label</a> to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.<sup id="cite_ref-FDA_PR_20201015_22-0" class="reference"><a href="#cite_note-FDA_PR_20201015-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_safety_20201015_23-0" class="reference"><a href="#cite_note-FDA_safety_20201015-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.<sup id="cite_ref-FDA_PR_20201015_22-1" class="reference"><a href="#cite_note-FDA_PR_20201015-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_safety_20201015_23-1" class="reference"><a href="#cite_note-FDA_safety_20201015-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Allergy">Allergy</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=4" title="Edit section: Allergy"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Celecoxib contains a <a href="/wiki/Sulfonamide_(chemistry)" class="mw-redirect" title="Sulfonamide (chemistry)">sulfonamide</a> moiety and may cause allergic reactions in those allergic to other sulfonamide-containing drugs. This is in addition to the contraindication in people with severe allergies to other NSAIDs. However, it has a low (reportedly 4%) chance of inducing cutaneous reactions among persons who have a history of such reactions to aspirin or nonselective NSAIDs. NSAIDs may cause serious skin adverse events, including <a href="/wiki/Exfoliative_dermatitis" class="mw-redirect" title="Exfoliative dermatitis">exfoliative dermatitis</a>, <a href="/wiki/Stevens%E2%80%93Johnson_syndrome" title="Stevens–Johnson syndrome">Stevens-Johnson syndrome</a>, and <a href="/wiki/Toxic_epidermal_necrolysis" title="Toxic epidermal necrolysis">toxic epidermal necrolysis</a>; events may occur without warning and in patients without prior known sulfa allergy. Use should be discontinued at the first sign of rash (or any other hypersensitivity). </p> <div class="mw-heading mw-heading3"><h3 id="Heart_attack_and_stroke">Heart attack and stroke</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=5" title="Edit section: Heart attack and stroke"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A 2013 meta-analysis of hundreds of clinical trials found that coxibs (the class of drugs that includes celecoxib) increase the risk of major cardiovascular problems by about 37% over placebo.<sup id="cite_ref-Coxib2013_8-3" class="reference"><a href="#cite_note-Coxib2013-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> In 2016, a randomized trial provided strong evidence that treatment with celecoxib is not more likely to result in poor cardiovascular outcomes than treatment with naproxen or ibuprofen.<sup id="cite_ref-NissenYeomans2016_24-0" class="reference"><a href="#cite_note-NissenYeomans2016-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> As a result, in 2018 an FDA advisory panel concluded that celecoxib poses no greater risk for causing heart attacks and strokes than the commonly-used NSAIDs ibuprofen or naproxen and recommended that the FDA consider changing its advice to physicians regarding celecoxib's safety.<sup id="cite_ref-NPR2018_11-1" class="reference"><a href="#cite_note-NPR2018-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>The COX-2 inhibitor <a href="/wiki/Rofecoxib" title="Rofecoxib">rofecoxib</a> (Vioxx) was removed from the market in 2004 due to its risk. Like all NSAIDs on the US market, celecoxib carries an FDA-mandated "black box warning" for cardiovascular and gastrointestinal risk. In February 2007, the <a href="/wiki/American_Heart_Association" title="American Heart Association">American Heart Association</a> warned that with respect to "patients with a prior history of or at high risk for cardiovascular disease... use of COX-2 inhibitors for pain relief should be limited to patients for whom there are no appropriate alternatives, and then, only in the lowest dose and for the shortest duration necessary."<sup id="cite_ref-AHA2007_9-1" class="reference"><a href="#cite_note-AHA2007-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>In 2005, a study published in the <i><a href="/wiki/Annals_of_Internal_Medicine" title="Annals of Internal Medicine">Annals of Internal Medicine</a></i> found that cardiovascular effects of COX-2 inhibitors differ, depending on the drug.<sup id="cite_ref-pmid15684203_25-0" class="reference"><a href="#cite_note-pmid15684203-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> Other COX-2-selective inhibitors, such as rofecoxib, have significantly higher myocardial infarction rates than celecoxib.<sup id="cite_ref-pmid11509060_26-0" class="reference"><a href="#cite_note-pmid11509060-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> In April 2005, after an extensive review of data, the FDA concluded it was likely "that there is a 'class effect' for increased CV risk for all NSAIDs".<sup id="cite_ref-Jenkins_27-0" class="reference"><a href="#cite_note-Jenkins-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> In a 2006 <a href="/wiki/Meta-analysis" title="Meta-analysis">meta-analysis</a> of randomized control studies, the <a href="/wiki/Cerebrovascular_disease" title="Cerebrovascular disease">cerebrovascular events</a> associated with COX-2 inhibitors were examined, but no significant risks were found when compared to nonselective NSAIDs or placebos.<sup id="cite_ref-pmid17176361_28-0" class="reference"><a href="#cite_note-pmid17176361-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Drug_interactions">Drug interactions</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=6" title="Edit section: Drug interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Celecoxib undergoes metabolism primarily by the enzymes <a href="/wiki/CYP2C9" title="CYP2C9">CYP2C9</a> and <a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a>, but it also interacts with <a href="/wiki/CYP2D6" title="CYP2D6">CYP2D6</a>, inhibiting its activity without being metabolized by it.<sup id="cite_ref-Shkundin_2025_29-0" class="reference"><a href="#cite_note-Shkundin_2025-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> The CYP2C9 gene exhibits considerable genetic variability, with common polymorphisms, such as <a href="/wiki/CYP2C9" title="CYP2C9"> rs1799853</a> and <a href="/wiki/CYP2C9" title="CYP2C9"> rs1057910</a>, linked to reduced enzyme activity and altered pharmacokinetics of celecoxib.<sup id="cite_ref-Shkundin_2025_29-1" class="reference"><a href="#cite_note-Shkundin_2025-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> Additionally, the influence of CYP2D6 on celecoxib metabolism is inconsistent, with its effect varying depending on the individual’s CYP2C9 genetic profile.<sup id="cite_ref-Shkundin_2025_29-2" class="reference"><a href="#cite_note-Shkundin_2025-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p><p>Caution must be exercised with concomitant use of 2C9 inhibitors, such as <a href="/wiki/Fluconazole" title="Fluconazole">fluconazole</a>, which can greatly elevate celecoxib serum levels.<sup id="cite_ref-Celebrex_FDA_label_5-2" class="reference"><a href="#cite_note-Celebrex_FDA_label-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> If used concomitantly with lithium, celecoxib increases lithium plasma levels.<sup id="cite_ref-Celebrex_FDA_label_5-3" class="reference"><a href="#cite_note-Celebrex_FDA_label-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> If used concomitantly with warfarin, celecoxib may result in an increased risk of bleeding complications.<sup id="cite_ref-Celebrex_FDA_label_5-4" class="reference"><a href="#cite_note-Celebrex_FDA_label-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The risk of bleeding and gastric ulcers also increases further when <a href="/wiki/Selective_serotonin_reuptake_inhibitor" title="Selective serotonin reuptake inhibitor">selective serotonin reuptake inhibitors</a> (SSRI) are used in combination with celecoxib.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> The drug may increase the risk of kidney failure with <a href="/wiki/Angiotensin" title="Angiotensin">angiotensin</a>-converting enzyme-inhibitors, such as <a href="/wiki/Lisinopril" title="Lisinopril">lisinopril</a>, and <a href="/wiki/Diuretic" title="Diuretic">diuretics</a>, such as <a href="/wiki/Hydrochlorothiazide" title="Hydrochlorothiazide">hydrochlorothiazide</a>.<sup id="cite_ref-Celebrex_FDA_label_5-5" class="reference"><a href="#cite_note-Celebrex_FDA_label-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Mechanism_of_action">Mechanism of action</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=7" title="Edit section: Mechanism of action"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Anti-inflammatory">Anti-inflammatory</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=8" title="Edit section: Anti-inflammatory"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A highly selective reversible inhibitor of the <a href="/wiki/COX-2" class="mw-redirect" title="COX-2">COX-2</a> isoform of <a href="/wiki/Cyclooxygenase" title="Cyclooxygenase">cyclooxygenase</a>, celecoxib inhibits the transformation of arachidonic acid to prostaglandin precursors. Therefore, it has analgesic and anti-inflammatory properties.<sup id="cite_ref-Celebrex_FDA_label_5-6" class="reference"><a href="#cite_note-Celebrex_FDA_label-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Nonselective NSAIDs (such as aspirin, naproxen, and ibuprofen) inhibit both <a href="/wiki/COX-1" class="mw-redirect" title="COX-1">COX-1</a> and COX-2. Inhibition of COX-1 (which celecoxib does not inhibit at therapeutic concentrations) inhibits the production of prostaglandins and the production of thromboxane A2, a platelet activator.<sup id="cite_ref-Celebrex_FDA_label_5-7" class="reference"><a href="#cite_note-Celebrex_FDA_label-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> COX-1 is traditionally defined as a constitutively expressed "housekeeping" enzyme and plays a role in the protection of the gastrointestinal mucosa, kidney hemodynamics, and platelet thrombogenesis.<sup id="cite_ref-Mathew_31-0" class="reference"><a href="#cite_note-Mathew-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Katzung_32-0" class="reference"><a href="#cite_note-Katzung-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> COX-2, on the contrary, is extensively expressed in cells involved in inflammation and is upregulated by bacterial lipopolysaccharides, cytokines, growth factors, and tumor promoters.<sup id="cite_ref-Mathew_31-1" class="reference"><a href="#cite_note-Mathew-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Shi_S_and_Koltz_U_33-0" class="reference"><a href="#cite_note-Shi_S_and_Koltz_U-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> Celecoxib is approximately 10-20 times more selective for COX-2 inhibition over COX-1.<sup id="cite_ref-Katzung_32-1" class="reference"><a href="#cite_note-Katzung-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> It binds with its polar <a href="/wiki/Sulfonamide_(chemistry)" class="mw-redirect" title="Sulfonamide (chemistry)">sulfonamide side chain</a> to a hydrophilic side pocket region close to the active COX-2 binding site.<sup id="cite_ref-DiPiro_2008_35-0" class="reference"><a href="#cite_note-DiPiro_2008-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup> In theory, this selectivity allows celecoxib and other COX-2 inhibitors to reduce <a href="/wiki/Inflammation" title="Inflammation">inflammation</a> (and pain) while minimizing gastrointestinal <a href="/wiki/Adverse_drug_reaction" title="Adverse drug reaction">adverse drug reactions</a> (e.g. <a href="/wiki/Stomach_ulcer" class="mw-redirect" title="Stomach ulcer">stomach ulcers</a>) that are common with nonselective NSAIDs.<sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Anti-cancer">Anti-cancer</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=9" title="Edit section: Anti-cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>For its use in reducing colon polyps, celecoxib affects genes and pathways involved in inflammation and malignant transformation in tumors, but not normal tissues.<sup id="cite_ref-37" class="reference"><a href="#cite_note-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> </p><p>Celecoxib binds to <a href="/wiki/Cadherin-11" class="mw-redirect" title="Cadherin-11">Cadherin-11</a> (which may explain the reduction in cancer progression).<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="removed citation to predatory publisher content (December 2019)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading2"><h2 id="Structure-activity_relationship">Structure-activity relationship</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=10" title="Edit section: Structure-activity relationship"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-right" typeof="mw:File"><a href="/wiki/File:Monosubstituted_1,5-diarylpyrazoles.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Monosubstituted_1%2C5-diarylpyrazoles.jpg/400px-Monosubstituted_1%2C5-diarylpyrazoles.jpg" decoding="async" width="400" height="228" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Monosubstituted_1%2C5-diarylpyrazoles.jpg/600px-Monosubstituted_1%2C5-diarylpyrazoles.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Monosubstituted_1%2C5-diarylpyrazoles.jpg/800px-Monosubstituted_1%2C5-diarylpyrazoles.jpg 2x" data-file-width="901" data-file-height="514" /></a><figcaption></figcaption></figure> <figure class="mw-halign-right" typeof="mw:File"><a href="/wiki/File:Enzyme_data_for_monosubstituted_5-aryl_analogs.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/77/Enzyme_data_for_monosubstituted_5-aryl_analogs.jpg/400px-Enzyme_data_for_monosubstituted_5-aryl_analogs.jpg" decoding="async" width="400" height="295" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/77/Enzyme_data_for_monosubstituted_5-aryl_analogs.jpg/600px-Enzyme_data_for_monosubstituted_5-aryl_analogs.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/77/Enzyme_data_for_monosubstituted_5-aryl_analogs.jpg/800px-Enzyme_data_for_monosubstituted_5-aryl_analogs.jpg 2x" data-file-width="1173" data-file-height="866" /></a><figcaption></figcaption></figure> <figure class="mw-halign-right" typeof="mw:File"><a href="/wiki/File:Enzyme_data_for_4-substituted_analogs.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/74/Enzyme_data_for_4-substituted_analogs.jpg/400px-Enzyme_data_for_4-substituted_analogs.jpg" decoding="async" width="400" height="215" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/74/Enzyme_data_for_4-substituted_analogs.jpg/600px-Enzyme_data_for_4-substituted_analogs.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/74/Enzyme_data_for_4-substituted_analogs.jpg/800px-Enzyme_data_for_4-substituted_analogs.jpg 2x" data-file-width="938" data-file-height="504" /></a><figcaption></figcaption></figure> <figure class="mw-halign-right" typeof="mw:File"><a href="/wiki/File:In_vitro_cox-I_and_cox-II_enzyme_data_for_disubstituted_5-aryl_analogs.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/67/In_vitro_cox-I_and_cox-II_enzyme_data_for_disubstituted_5-aryl_analogs.jpg/400px-In_vitro_cox-I_and_cox-II_enzyme_data_for_disubstituted_5-aryl_analogs.jpg" decoding="async" width="400" height="172" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/67/In_vitro_cox-I_and_cox-II_enzyme_data_for_disubstituted_5-aryl_analogs.jpg/600px-In_vitro_cox-I_and_cox-II_enzyme_data_for_disubstituted_5-aryl_analogs.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/67/In_vitro_cox-I_and_cox-II_enzyme_data_for_disubstituted_5-aryl_analogs.jpg/800px-In_vitro_cox-I_and_cox-II_enzyme_data_for_disubstituted_5-aryl_analogs.jpg 2x" data-file-width="981" data-file-height="422" /></a><figcaption></figcaption></figure> <p>The Searle research group found the two appropriately substituted aromatic rings must reside on adjacent positions about the central ring for adequate COX-2 inhibition. Various modifications can be made to the 1,5-diarylpyrazole moiety to deduce the structure-activity relationship of celecoxib.<sup id="cite_ref-Penning_38-0" class="reference"><a href="#cite_note-Penning-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> A para-sulfamoylphenyl at position 1 of the pyrazole was found to have a higher potency for COX-2 selective inhibition than a para-methoxyphenyl (see structures 1 and 2, below). In addition, a 4-(methylsulfonyl)phenyl or 4-sulfamoylphenyl is known to be necessary for COX-2 inhibition. For instance, replacing either of these entities with a –SO<sub>2</sub>NHCH<sub>3</sub> substituent diminishes COX-2 inhibitory activity as noted with a very high inhibitory concentration-50 (see structures 3 – 5). At the 3-position of the pyrazole, a trifluoromethyl or difluoromethyl provides superior selectivity and potency compared to a fluoromethyl or methyl substitution (see structures 6 – 9).<sup id="cite_ref-Penning_38-1" class="reference"><a href="#cite_note-Penning-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> </p><p>Celecoxib is compound 22; the 4-sulfamoylphenyl on the 1-pyrazol substituent is required for COX-2 inhibition and the 4-methyl on the 5-pyrazol system has low steric hindrance to maximising potency, while the 3-trifluoromethyl group provides superior selectivity and potency.<sup id="cite_ref-Penning_38-2" class="reference"><a href="#cite_note-Penning-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> To explain the selectivity of celecoxib, it is necessary to analyze the free energy of binding difference between the drug molecule and COX-1 compared to COX-2 enzymes. The structural modifications highlight the importance of binding to residue 523 in the side binding pocket of the cyclooxygenase enzyme, which is an isoleucine in COX-1 and a valine in COX-2.<sup id="cite_ref-Price_39-0" class="reference"><a href="#cite_note-Price-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> This mutation appears to contribute to COX-2 selectivity by creating steric hindrance between the sulfonamide oxygen and the methyl group of Ile523 that effectively destabilizes the celecoxib-COX-1 complex.<sup id="cite_ref-Price_39-1" class="reference"><a href="#cite_note-Price-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=11" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Discovery_and_development_of_cyclooxygenase_2_inhibitors" title="Discovery and development of cyclooxygenase 2 inhibitors">Discovery and development of cyclooxygenase 2 inhibitors</a></div> <p>It was initially marketed by <a href="/wiki/Pfizer" title="Pfizer">Pfizer</a> for arthritis. Celecoxib and other COX-2 selective inhibitors, <a href="/wiki/Valdecoxib" title="Valdecoxib">valdecoxib</a>, <a href="/wiki/Parecoxib" title="Parecoxib">parecoxib</a>, and <a href="/wiki/Mavacoxib" title="Mavacoxib">mavacoxib</a>, were discovered by a team at the <a href="/wiki/G.D._Searle,_LLC" title="G.D. Searle, LLC">Searle</a> division of <a href="/wiki/Monsanto" title="Monsanto">Monsanto</a> led by <a href="/wiki/John_Talley_(chemist)" title="John Talley (chemist)">John Talley</a>.<sup id="cite_ref-Forbes2003_40-0" class="reference"><a href="#cite_note-Forbes2003-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SLACS_41-0" class="reference"><a href="#cite_note-SLACS-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> </p><p>Two lawsuits arose over the discovery of celecoxib. Daniel L. Simmons of <a href="/wiki/Brigham_Young_University" title="Brigham Young University">Brigham Young University</a> (BYU) discovered the COX-2 enzyme in 1988,<sup id="cite_ref-ScientistBYULitig_42-0" class="reference"><a href="#cite_note-ScientistBYULitig-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup> and in 1991, BYU entered into a collaboration with <a href="/wiki/Monsanto" title="Monsanto">Monsanto</a> to develop drugs to inhibit it. Monsanto's pharmaceutical division was later purchased by <a href="/wiki/Pfizer" title="Pfizer">Pfizer</a>, and in 2006, BYU sued Pfizer for breach of contract, claiming Pfizer did not properly pay contractual royalties back to BYU.<sup id="cite_ref-Deseret_News_43-0" class="reference"><a href="#cite_note-Deseret_News-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> A settlement was reached in April 2012, in which Pfizer agreed to pay $450 million.<sup id="cite_ref-Settlement_44-0" class="reference"><a href="#cite_note-Settlement-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-45" class="reference"><a href="#cite_note-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> Other important discoveries in COX-2 were made at <a href="/wiki/University_of_Rochester" title="University of Rochester">University of Rochester</a>, which patented the discoveries.<sup id="cite_ref-46" class="reference"><a href="#cite_note-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> When the patent was issued, the university sued Searle (later Pfizer) in a case called, <i>University of Rochester v. G.D. Searle & Co.</i>, 358 F.3d 916 (Fed. Cir. 2004). The court ruled in favor of Searle in 2004, holding in essence that the university had claimed a method requiring, yet provided no written description of, a compound that could inhibit COX-2, and therefore the patent was invalid.<sup id="cite_ref-hodgsonruss_47-0" class="reference"><a href="#cite_note-hodgsonruss-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-kayescholer_48-0" class="reference"><a href="#cite_note-kayescholer-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> </p><p>According to the <a href="/wiki/National_Academy_of_Sciences" title="National Academy of Sciences">National Academy of Sciences</a>, <a href="/wiki/Philip_Needleman" title="Philip Needleman">Philip Needleman</a>, who was vice president of <a href="/wiki/Monsanto" title="Monsanto">Monsanto</a> in 1989 and president of <a href="/wiki/G._D._Searle_%26_Company" class="mw-redirect" title="G. D. Searle & Company">Searle</a> in 1993<sup id="cite_ref-NASO_49-0" class="reference"><a href="#cite_note-NASO-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> oversaw research into <a href="/wiki/COX-2" class="mw-redirect" title="COX-2">COX-2</a> that led to the development of the anti-inflammatory drug celecoxib (Celebrex).<sup id="cite_ref-NASO_49-1" class="reference"><a href="#cite_note-NASO-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> He became senior executive vice president and chief scientist of <a href="/wiki/Pharmacia" title="Pharmacia">Pharmacia</a> from 2000 to 2003.<sup id="cite_ref-NASO_49-2" class="reference"><a href="#cite_note-NASO-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> Celecoxib was discovered and<sup id="cite_ref-50" class="reference"><a href="#cite_note-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup> developed by G. D. Searle & Company and was approved by the FDA on 31 December 1998.<sup id="cite_ref-51" class="reference"><a href="#cite_note-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup> It was co-promoted by Monsanto Company (parent company of Searle) and Pfizer under the brand name Celebrex. Monsanto merged with <a href="/wiki/Pharmacia" title="Pharmacia">Pharmacia</a>, from which the Medical Research Division was acquired by Pfizer, giving Pfizer ownership of Celebrex. The drug was at the core of a major patent dispute that was resolved in Searle's favor (later Pfizer) in 2004.<sup id="cite_ref-hodgsonruss_47-1" class="reference"><a href="#cite_note-hodgsonruss-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-kayescholer_48-1" class="reference"><a href="#cite_note-kayescholer-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> In <i>University of Rochester v. G.D. Searle & Co.</i>, 358 F.3d 916 (Fed. Cir. 2004), the <a href="/wiki/University_of_Rochester" title="University of Rochester">University of Rochester</a> claimed that United States Pat. No. 6,048,850 (which claimed a method of inhibiting COX-2 in humans using a compound, without actually disclosing what that compound might be) covered drugs such as celecoxib. The court ruled in favor of Searle, holding in essence that the university had claimed a method requiring, yet provided no written description of, a compound that could inhibit COX-2, and therefore the patent was invalid. </p><p>After the withdrawal of rofecoxib from the market in September 2004, celecoxib enjoyed a robust increase in sales. However, the results of the APC trial in December of that year raised concerns that Celebrex might carry risks similar to those of rofecoxib, and Pfizer announced a moratorium on <a href="/wiki/Direct-to-consumer_advertising" title="Direct-to-consumer advertising">direct-to-consumer advertising</a> of Celebrex soon afterward. Sales reached $2 billion in 2006.<sup id="cite_ref-AHA2007_9-2" class="reference"><a href="#cite_note-AHA2007-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Before its availability in generic form, it was one of Pfizer's "best-selling drugs, amounting to more than $2.5 billion in sales [by 2012], and was prescribed to 2.4 million" people in 2011.<sup id="cite_ref-NYT2012_52-0" class="reference"><a href="#cite_note-NYT2012-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> By 2012, 33 million Americans had taken celecoxib.<sup id="cite_ref-NYT2012_52-1" class="reference"><a href="#cite_note-NYT2012-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> </p><p>Pfizer resumed advertising Celebrex in magazines in 2006,<sup id="cite_ref-Berenson_53-0" class="reference"><a href="#cite_note-Berenson-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup> and resumed television advertising in April 2007 with an unorthodox, <style data-mw-deduplicate="TemplateStyles:r1154941027">.mw-parser-output .frac{white-space:nowrap}.mw-parser-output .frac .num,.mw-parser-output .frac .den{font-size:80%;line-height:0;vertical-align:super}.mw-parser-output .frac .den{vertical-align:sub}.mw-parser-output .sr-only{border:0;clip:rect(0,0,0,0);clip-path:polygon(0px 0px,0px 0px,0px 0px);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}</style><span class="frac">2<span class="sr-only">+</span><span class="num">1</span>⁄<span class="den">2</span></span>-minute advertisement which extensively discussed the adverse effects of Celebrex in comparison with other anti-inflammatory drugs. The ad drew criticism from the consumer advocacy group <a href="/wiki/Public_Citizen" title="Public Citizen">Public Citizen</a>, which called the ad's comparisons misleading.<sup id="cite_ref-Saul_54-0" class="reference"><a href="#cite_note-Saul-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup> Pfizer responded to Public Citizen's concerns with assurances that they are truthfully advertising the risk and benefits of Celebrex as set forth by the FDA.<sup id="cite_ref-Saul_54-1" class="reference"><a href="#cite_note-Saul-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=12" title="Edit section: Society and culture"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Fabricated_efficacy_studies">Fabricated efficacy studies</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=13" title="Edit section: Fabricated efficacy studies"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Pfizer" title="Pfizer">Pfizer</a> and its partner, <a href="/wiki/Pharmacia" title="Pharmacia">Pharmacia</a> presented findings from their study that Celebrex was "better in protecting the stomach from serious complications than other drugs."<sup id="cite_ref-NYT2012_52-2" class="reference"><a href="#cite_note-NYT2012-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> This became Celebrex's main selling point. However, following federal investigations it was revealed that Pfizer and Pharmacia "only presented the results from the first six months of a year-long study rather than the whole thing." These partial results were then published in <a href="/wiki/The_Journal_of_the_American_Medical_Association" class="mw-redirect" title="The Journal of the American Medical Association">The Journal of the American Medical Association</a>.<sup id="cite_ref-NYT2012_52-3" class="reference"><a href="#cite_note-NYT2012-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> In 2001, the US <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) released the full results of the Pfizer and Pharmacia study which showed that they had withheld crucial data.<sup id="cite_ref-NYT2012_52-4" class="reference"><a href="#cite_note-NYT2012-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> By 2012, a federal judge unsealed "thousands of pages of internal documents and depositions" in a "long-running securities fraud case against Pfizer."<sup id="cite_ref-NYT2012_52-5" class="reference"><a href="#cite_note-NYT2012-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> </p><p>In March 2009, <a href="/wiki/Scott_S._Reuben" class="mw-redirect" title="Scott S. Reuben">Scott S. Reuben</a>, former chief of acute pain at <a href="/wiki/Baystate_Medical_Center" class="mw-redirect" title="Baystate Medical Center">Baystate Medical Center</a>, Springfield, Massachusetts, revealed that the data for 21 studies he had authored for the efficacy of the drug (along with others such as <a href="/wiki/Vioxx" class="mw-redirect" title="Vioxx">Vioxx</a>) had been fabricated. The analgesic effects of the drugs had been exaggerated. Reuben was also a former paid spokesperson for Pfizer. Although from 2002 to 2007 Pfizer underwrote much of Dr. Reuben's research and "many of his trials found that Celebrex and Lyrica, Pfizer drugs, were effective against postoperative pain," Pfizer was not aware of the fraudulent data.<sup id="cite_ref-nyt0311_55-0" class="reference"><a href="#cite_note-nyt0311-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup><sup class="noprint Inline-Template" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Verifiability" title="Wikipedia:Verifiability"><span title="The material near this tag failed verification of its source citation(s). (August 2018)">failed verification</span></a></i>]</sup> None of the retracted studies were submitted to either the US <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> or the European Union's regulatory agencies before the drug's approval. Although Pfizer issued a public statement declaring, "It is very disappointing to learn about Dr. Scott Reuben's alleged actions. When we decided to support Dr. Reuben's research, he worked for a credible academic medical center and appeared to be a reputable investigator",<sup id="cite_ref-WSJ-3-2009_56-0" class="reference"><a href="#cite_note-WSJ-3-2009-56"><span class="cite-bracket">[</span>56<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-57" class="reference"><a href="#cite_note-57"><span class="cite-bracket">[</span>57<span class="cite-bracket">]</span></a></sup> the documents unsealed in 2012, revealed that by February 2000, Pharmacia employees had devised a strategy to present the findings.<sup id="cite_ref-NYT2012_52-6" class="reference"><a href="#cite_note-NYT2012-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Brand_names">Brand names</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=14" title="Edit section: Brand names"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Pfizer markets celecoxib under the brand name Celebrex, and it is available as oral capsules containing 50, 100, 200, or 400 mg of celecoxib.<sup id="cite_ref-Celebrex_FDA_label_5-8" class="reference"><a href="#cite_note-Celebrex_FDA_label-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>It is legally available in many jurisdictions as a generic under several brand names.<sup id="cite_ref-58" class="reference"><a href="#cite_note-58"><span class="cite-bracket">[</span>58<span class="cite-bracket">]</span></a></sup> In the US, celecoxib was covered by three patents, two of which expired on 30 May 2014, and one of which (US RE44048<sup id="cite_ref-59" class="reference"><a href="#cite_note-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup>) was due to expire 2 December 2015. On 13 March 2014, that patent was found to be invalid for <a href="/wiki/Double_patenting" title="Double patenting">double patenting</a>.<sup id="cite_ref-60" class="reference"><a href="#cite_note-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup> Upon the patent expiry on 30 May 2014, the FDA approved the first versions of generic celecoxib.<sup id="cite_ref-61" class="reference"><a href="#cite_note-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup> </p><p>In the US, Celebrex is marketed by <a href="/wiki/Viatris" title="Viatris">Viatris</a> after Upjohn was spun off from Pfizer.<sup id="cite_ref-62" class="reference"><a href="#cite_note-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-63" class="reference"><a href="#cite_note-63"><span class="cite-bracket">[</span>63<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-64" class="reference"><a href="#cite_note-64"><span class="cite-bracket">[</span>64<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Research">Research</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=15" title="Edit section: Research"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Psychiatry">Psychiatry</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=16" title="Edit section: Psychiatry"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>On the theory that inflammation plays a role in the pathogenesis of major mental disorders, celecoxib has been trialed for a number of psychiatric disorders, including <a href="/wiki/Major_depression" class="mw-redirect" title="Major depression">major depression</a>, <a href="/wiki/Bipolar_disorder" title="Bipolar disorder">bipolar disorder</a>, and <a href="/wiki/Schizophrenia" title="Schizophrenia">schizophrenia</a>.<sup id="cite_ref-repurposed2021_65-0" class="reference"><a href="#cite_note-repurposed2021-65"><span class="cite-bracket">[</span>65<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-66" class="reference"><a href="#cite_note-66"><span class="cite-bracket">[</span>66<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-67" class="reference"><a href="#cite_note-67"><span class="cite-bracket">[</span>67<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-68" class="reference"><a href="#cite_note-68"><span class="cite-bracket">[</span>68<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-69" class="reference"><a href="#cite_note-69"><span class="cite-bracket">[</span>69<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Bipolar_disorder">Bipolar disorder</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=17" title="Edit section: Bipolar disorder"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A meta-analysis considering trials of celecoxib as an adjunctive treatment in <a href="/wiki/Bipolar_disorder" title="Bipolar disorder">bipolar disorder</a> was inconclusive citing low evidence quality.<sup id="cite_ref-repurposed2021_65-1" class="reference"><a href="#cite_note-repurposed2021-65"><span class="cite-bracket">[</span>65<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Familial_adenomatous_polyposis_2">Familial adenomatous polyposis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=18" title="Edit section: Familial adenomatous polyposis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>It has been used to reduce colon and rectal polyps in people with familial adenomatous polyposis, but it is not known if it decreases rates of <a href="/wiki/Cancer" title="Cancer">cancer</a>,<sup id="cite_ref-AHFS2019_7-12" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> so it is not a good choice for this reason.<sup id="cite_ref-AHFS2019_7-13" class="reference"><a href="#cite_note-AHFS2019-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Cancer_prevention">Cancer prevention</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=19" title="Edit section: Cancer prevention"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The use of celecoxib to reduce the risk of <a href="/wiki/Colorectal_cancer" title="Colorectal cancer">colorectal cancer</a> has been investigated, but neither celecoxib nor any other drug is indicated for this use.<sup id="cite_ref-70" class="reference"><a href="#cite_note-70"><span class="cite-bracket">[</span>70<span class="cite-bracket">]</span></a></sup> Small-scale clinical trials in very high-risk people (belonging to <a href="/wiki/Familial_adenomatous_polyposis" title="Familial adenomatous polyposis">FAP</a> families) showed celecoxib can prevent polyp growth. Hence, large-scale randomized clinical trials were undertaken.<sup id="cite_ref-Bertagnolli_71-0" class="reference"><a href="#cite_note-Bertagnolli-71"><span class="cite-bracket">[</span>71<span class="cite-bracket">]</span></a></sup> Results show a 33 to 45% polyp recurrence reduction in people treated with celecoxib each day. However, serious cardiovascular events were significantly more frequent in the celecoxib-treated groups. Aspirin shows a similar (and possibly larger) protective effect,<sup id="cite_ref-Baron_72-0" class="reference"><a href="#cite_note-Baron-72"><span class="cite-bracket">[</span>72<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Sandler_73-0" class="reference"><a href="#cite_note-Sandler-73"><span class="cite-bracket">[</span>73<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Bosetti_74-0" class="reference"><a href="#cite_note-Bosetti-74"><span class="cite-bracket">[</span>74<span class="cite-bracket">]</span></a></sup> has demonstrated cardioprotective effects and is significantly cheaper, but no head-to-head clinical trials have compared the two drugs. </p> <div class="mw-heading mw-heading3"><h3 id="Cancer_treatment">Cancer treatment</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=20" title="Edit section: Cancer treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Different from cancer prevention, cancer treatment is focused on the therapy of tumors that have already formed and have established themselves inside the patient. Many studies are going on to determine whether celecoxib might be useful for this latter condition.<sup id="cite_ref-Dannenberg_75-0" class="reference"><a href="#cite_note-Dannenberg-75"><span class="cite-bracket">[</span>75<span class="cite-bracket">]</span></a></sup> However, during molecular studies in the laboratory, it became apparent that celecoxib could interact with other intracellular components besides its most famous target, COX-2. The discovery of these additional targets has generated much controversy, and the initial assumption that celecoxib reduces tumor growth primarily by the inhibition of COX-2 became contentious.<sup id="cite_ref-76" class="reference"><a href="#cite_note-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup> </p><p>Certainly, the inhibition of COX-2 is paramount for the anti-inflammatory and analgesic function of celecoxib. However, whether inhibition of COX-2 also plays a dominant role in this drug's anticancer effects is unclear. For example, a recent study with <a href="/wiki/Malignant_tumor" class="mw-redirect" title="Malignant tumor">malignant tumor</a> cells showed celecoxib could inhibit the growth of these cells <i><a href="/wiki/In_vitro" title="In vitro">in vitro</a></i>, but COX-2 played no role in this outcome; even more strikingly, the anticancer effects of celecoxib were also obtained with the use of cancer cell types that do not even contain COX-2.<sup id="cite_ref-Chuang_77-0" class="reference"><a href="#cite_note-Chuang-77"><span class="cite-bracket">[</span>77<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Karen_Seibert" title="Karen Seibert">Karen Seibert</a> and colleagues have published research showing antiangiogenic and antitumor activity of celecoxib in animal models.<sup id="cite_ref-78" class="reference"><a href="#cite_note-78"><span class="cite-bracket">[</span>78<span class="cite-bracket">]</span></a></sup> </p><p>Additional support for the idea that other targets besides COX-2 are important for celecoxib's anticancer effects has come from studies with chemically modified versions of celecoxib. Several dozen <a href="/wiki/Analog_(chemistry)" class="mw-redirect" title="Analog (chemistry)">analogs</a> of celecoxib were generated with small alterations in their <a href="/wiki/Chemical_structure" title="Chemical structure">chemical structures</a>.<sup id="cite_ref-zhu_79-0" class="reference"><a href="#cite_note-zhu-79"><span class="cite-bracket">[</span>79<span class="cite-bracket">]</span></a></sup> Some of these analogs retained COX-2 inhibitory activity, whereas many others did not. However, when the ability of all these compounds to kill tumor cells in <a href="/wiki/Cell_culture" title="Cell culture">cell culture</a> was investigated, the antitumor potency did not at all depend on whether or not the respective compound could inhibit COX-2, showing the inhibition of COX-2 was not required for the anticancer effects.<sup id="cite_ref-zhu_79-1" class="reference"><a href="#cite_note-zhu-79"><span class="cite-bracket">[</span>79<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Schönthal-analogs_80-0" class="reference"><a href="#cite_note-Schönthal-analogs-80"><span class="cite-bracket">[</span>80<span class="cite-bracket">]</span></a></sup> One of these compounds, <a href="/w/index.php?title=2,5-dimethyl-celecoxib&action=edit&redlink=1" class="new" title="2,5-dimethyl-celecoxib (page does not exist)">2,5-dimethyl-celecoxib</a>, which entirely lacks the ability to inhibit COX-2, actually displayed stronger anticancer activity than celecoxib.<sup id="cite_ref-Schönthal-antitumor_81-0" class="reference"><a href="#cite_note-Schönthal-antitumor-81"><span class="cite-bracket">[</span>81<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=21" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-Drugs.com_pregnancy-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-Drugs.com_pregnancy_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Drugs.com_pregnancy_1-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/pregnancy/celecoxib.html">"Celecoxib (Celebrex) Use During Pregnancy"</a>. <i>Drugs.com</i>. 4 May 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210125072333/https://www.drugs.com/pregnancy/celecoxib.html">Archived</a> from the original on 25 January 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">5 May</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drugs.com&rft.atitle=Celecoxib+%28Celebrex%29+Use+During+Pregnancy&rft.date=2020-05-04&rft_id=https%3A%2F%2Fwww.drugs.com%2Fpregnancy%2Fcelecoxib.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-FDA-AllBoxedWarnings-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-FDA-AllBoxedWarnings_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802">"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"</a>. <i>nctr-crs.fda.gov</i>. <a href="/wiki/FDA" class="mw-redirect" title="FDA">FDA</a><span class="reference-accessdate">. Retrieved <span class="nowrap">22 October</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=nctr-crs.fda.gov&rft.atitle=FDA-sourced+list+of+all+drugs+with+black+box+warnings+%28Use+Download+Full+Results+and+View+Query+links.%29&rft_id=https%3A%2F%2Fnctr-crs.fda.gov%2Ffdalabel%2Fui%2Fspl-summaries%2Fcriteria%2F343802&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAnvisa2023" class="citation web cs1 cs1-prop-foreign-lang-source"><a href="/wiki/Brazilian_Health_Regulatory_Agency" title="Brazilian Health Regulatory Agency">Anvisa</a> (31 March 2023). <a rel="nofollow" class="external text" href="https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992">"RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial"</a> [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). <a href="/wiki/Di%C3%A1rio_Oficial_da_Uni%C3%A3o" title="Diário Oficial da União">Diário Oficial da União</a> (published 4 April 2023). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20230803143925/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992">Archived</a> from the original on 3 August 2023<span class="reference-accessdate">. Retrieved <span class="nowrap">16 August</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=RDC+N%C2%BA+784+-+Listas+de+Subst%C3%A2ncias+Entorpecentes%2C+Psicotr%C3%B3picas%2C+Precursoras+e+Outras+sob+Controle+Especial&rft.pub=Di%C3%A1rio+Oficial+da+Uni%C3%A3o&rft.date=2023-03-31&rft.au=Anvisa&rft_id=https%3A%2F%2Fwww.in.gov.br%2Fen%2Fweb%2Fdou%2F-%2Fresolucao-rdc-n-784-de-31-de-marco-de-2023-474904992&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.medicines.org.uk/emc/product/5533/smpc">"Celebrex 100mg capsule - Summary of Product Characteristics (SmPC)"</a>. <i>(emc)</i>. 13 January 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200806222736/https://www.medicines.org.uk/emc/product/5533/smpc">Archived</a> from the original on 6 August 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">5 May</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=%28emc%29&rft.atitle=Celebrex+100mg+capsule+-+Summary+of+Product+Characteristics+%28SmPC%29&rft.date=2020-01-13&rft_id=https%3A%2F%2Fwww.medicines.org.uk%2Femc%2Fproduct%2F5533%2Fsmpc&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Celebrex_FDA_label-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-Celebrex_FDA_label_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Celebrex_FDA_label_5-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Celebrex_FDA_label_5-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Celebrex_FDA_label_5-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Celebrex_FDA_label_5-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-Celebrex_FDA_label_5-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-Celebrex_FDA_label_5-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-Celebrex_FDA_label_5-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-Celebrex_FDA_label_5-8"><sup><i><b>i</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d52185d-421f-4e34-8db7-f7676db2a226">"Celebrex- celecoxib capsule"</a>. <i>DailyMed</i>. 31 May 2019. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210224181140/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d52185d-421f-4e34-8db7-f7676db2a226">Archived</a> from the original on 24 February 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">5 May</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DailyMed&rft.atitle=Celebrex-+celecoxib+capsule&rft.date=2019-05-31&rft_id=https%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2FdrugInfo.cfm%3Fsetid%3D8d52185d-421f-4e34-8db7-f7676db2a226&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-drugs-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-drugs_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-drugs_6-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-drugs_6-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-drugs_6-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-drugs_6-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMcCormack2011" class="citation journal cs1">McCormack PL (December 2011). "Celecoxib: a review of its use for symptomatic relief in the treatment of Osteoarthritis, Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis". <i>Drugs</i>. <b>71</b> (18): <span class="nowrap">2457–</span>89. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2165%2F11208240-000000000-00000">10.2165/11208240-000000000-00000</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22141388">22141388</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:71357689">71357689</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drugs&rft.atitle=Celecoxib%3A+a+review+of+its+use+for+symptomatic+relief+in+the+treatment+of+Osteoarthritis%2C+Rheumatoid+Arthritis%2C+Psoriatic+Arthritis+and+Ankylosing+Spondylitis&rft.volume=71&rft.issue=18&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2457-%3C%2Fspan%3E89&rft.date=2011-12&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A71357689%23id-name%3DS2CID&rft_id=info%3Apmid%2F22141388&rft_id=info%3Adoi%2F10.2165%2F11208240-000000000-00000&rft.aulast=McCormack&rft.aufirst=PL&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-AHFS2019-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-AHFS2019_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-AHFS2019_7-13"><sup><i><b>n</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/celecoxib.html">"Celecoxib Monograph for Professionals"</a>. <i>Drugs.com</i>. American Society of Health-System Pharmacists. 11 November 2019. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190520124313/https://www.drugs.com/monograph/celecoxib.html">Archived</a> from the original on 20 May 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">5 May</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drugs.com&rft.atitle=Celecoxib+Monograph+for+Professionals&rft.date=2019-11-11&rft_id=https%3A%2F%2Fwww.drugs.com%2Fmonograph%2Fcelecoxib.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Coxib2013-8"><span class="mw-cite-backlink">^ <a href="#cite_ref-Coxib2013_8-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Coxib2013_8-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Coxib2013_8-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Coxib2013_8-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBhalaEmbersonMerhiAbramson2013" class="citation journal cs1">Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, et al. (August 2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778977">"Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials"</a>. <i>Lancet</i>. <b>382</b> (9894): <span class="nowrap">769–</span>79. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0140-6736%2813%2960900-9">10.1016/S0140-6736(13)60900-9</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778977">3778977</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23726390">23726390</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Vascular+and+upper+gastrointestinal+effects+of+non-steroidal+anti-inflammatory+drugs%3A+meta-analyses+of+individual+participant+data+from+randomised+trials&rft.volume=382&rft.issue=9894&rft.pages=%3Cspan+class%3D%22nowrap%22%3E769-%3C%2Fspan%3E79&rft.date=2013-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3778977%23id-name%3DPMC&rft_id=info%3Apmid%2F23726390&rft_id=info%3Adoi%2F10.1016%2FS0140-6736%2813%2960900-9&rft.aulast=Bhala&rft.aufirst=N&rft.au=Emberson%2C+J&rft.au=Merhi%2C+A&rft.au=Abramson%2C+S&rft.au=Arber%2C+N&rft.au=Baron%2C+JA&rft.au=Bombardier%2C+C&rft.au=Cannon%2C+C&rft.au=Farkouh%2C+ME&rft.au=FitzGerald%2C+GA&rft.au=Goss%2C+P&rft.au=Halls%2C+H&rft.au=Hawk%2C+E&rft.au=Hawkey%2C+C&rft.au=Hennekens%2C+C&rft.au=Hochberg%2C+M&rft.au=Holland%2C+LE&rft.au=Kearney%2C+PM&rft.au=Laine%2C+L&rft.au=Lanas%2C+A&rft.au=Lance%2C+P&rft.au=Laupacis%2C+A&rft.au=Oates%2C+J&rft.au=Patrono%2C+C&rft.au=Schnitzer%2C+TJ&rft.au=Solomon%2C+S&rft.au=Tugwell%2C+P&rft.au=Wilson%2C+K&rft.au=Wittes%2C+J&rft.au=Baigent%2C+C&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3778977&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-AHA2007-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-AHA2007_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-AHA2007_9-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-AHA2007_9-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAntmanBennettDaughertyFurberg2007" class="citation journal cs1">Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA (March 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1161%2Fcirculationaha.106.181424">"Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association"</a>. <i>Circulation</i>. <b>115</b> (12): <span class="nowrap">1634–</span>42. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1161%2Fcirculationaha.106.181424">10.1161/circulationaha.106.181424</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17325246">17325246</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Use+of+nonsteroidal+antiinflammatory+drugs%3A+an+update+for+clinicians%3A+a+scientific+statement+from+the+American+Heart+Association&rft.volume=115&rft.issue=12&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1634-%3C%2Fspan%3E42&rft.date=2007-03&rft_id=info%3Adoi%2F10.1161%2Fcirculationaha.106.181424&rft_id=info%3Apmid%2F17325246&rft.aulast=Antman&rft.aufirst=EM&rft.au=Bennett%2C+JS&rft.au=Daugherty%2C+A&rft.au=Furberg%2C+C&rft.au=Roberts%2C+H&rft.au=Taubert%2C+KA&rft_id=https%3A%2F%2Fdoi.org%2F10.1161%252Fcirculationaha.106.181424&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Consumer2012-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-Consumer2012_10-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.consumerreports.org/cro/2012/05/should-you-still-take-celebrex/index.htm">"Should you still take Celebrex?"</a>. <i><a href="/wiki/Consumer_Reports" title="Consumer Reports">Consumer Reports</a></i>. August 2009. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20151218111927/http://www.consumerreports.org/cro/2012/05/should-you-still-take-celebrex/index.htm">Archived</a> from the original on 18 December 2015<span class="reference-accessdate">. Retrieved <span class="nowrap">27 December</span> 2015</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Consumer+Reports&rft.atitle=Should+you+still+take+Celebrex%3F&rft.date=2009-08&rft_id=http%3A%2F%2Fwww.consumerreports.org%2Fcro%2F2012%2F05%2Fshould-you-still-take-celebrex%2Findex.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-NPR2018-11"><span class="mw-cite-backlink">^ <a href="#cite_ref-NPR2018_11-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-NPR2018_11-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStein2018" class="citation news cs1">Stein R (25 April 2018). <a rel="nofollow" class="external text" href="https://www.npr.org/sections/health-shots/2018/04/25/605226604/fda-panel-affirms-safety-of-painkiller-celebrex">"FDA Panel Affirms Safety Of Painkiller Celebrex"</a>. <a href="/wiki/NPR" title="NPR">NPR</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180520123906/https://www.npr.org/sections/health-shots/2018/04/25/605226604/fda-panel-affirms-safety-of-painkiller-celebrex">Archived</a> from the original on 20 May 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">19 May</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=FDA+Panel+Affirms+Safety+Of+Painkiller+Celebrex&rft.date=2018-04-25&rft.aulast=Stein&rft.aufirst=R&rft_id=https%3A%2F%2Fwww.npr.org%2Fsections%2Fhealth-shots%2F2018%2F04%2F25%2F605226604%2Ffda-panel-affirms-safety-of-painkiller-celebrex&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Fis2006-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-Fis2006_12-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFischerGanellin2006" class="citation book cs1">Fischer J, Ganellin CR (2006). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA522"><i>Analogue-based Drug Discovery</i></a>. John Wiley & Sons. p. 522. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9783527607495" title="Special:BookSources/9783527607495"><bdi>9783527607495</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210427093939/https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA522">Archived</a> from the original on 27 April 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">13 October</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Analogue-based+Drug+Discovery&rft.pages=522&rft.pub=John+Wiley+%26+Sons&rft.date=2006&rft.isbn=9783527607495&rft.aulast=Fischer&rft.aufirst=J&rft.au=Ganellin%2C+CR&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DFjKfqkaKkAAC%26pg%3DPA522&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-BNF76-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-BNF76_13-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation book cs1"><i>British national formulary : BNF 76</i> (76 ed.). Pharmaceutical Press. 2018. pp. <span class="nowrap">1097–</span>1098. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780857113382" title="Special:BookSources/9780857113382"><bdi>9780857113382</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=British+national+formulary+%3A+BNF+76&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1097-%3C%2Fspan%3E1098&rft.edition=76&rft.pub=Pharmaceutical+Press&rft.date=2018&rft.isbn=9780857113382&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://clincalc.com/DrugStats/Top300Drugs.aspx">"The Top 300 of 2022"</a>. <i>ClinCalc</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx">Archived</a> from the original on 30 August 2024<span class="reference-accessdate">. Retrieved <span class="nowrap">30 August</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=ClinCalc&rft.atitle=The+Top+300+of+2022&rft_id=https%3A%2F%2Fclincalc.com%2FDrugStats%2FTop300Drugs.aspx&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://clincalc.com/DrugStats/Drugs/Celecoxib">"Celecoxib Drug Usage Statistics, United States, 2013 - 2022"</a>. <i>ClinCalc</i><span class="reference-accessdate">. Retrieved <span class="nowrap">30 August</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=ClinCalc&rft.atitle=Celecoxib+Drug+Usage+Statistics%2C+United+States%2C+2013+-+2022&rft_id=https%3A%2F%2Fclincalc.com%2FDrugStats%2FDrugs%2FCelecoxib&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDerryMoore2013" class="citation journal cs1">Derry S, Moore RA (October 2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161494">"Single dose oral celecoxib for acute postoperative pain in adults"</a>. <i>The Cochrane Database of Systematic Reviews</i>. <b>10</b> (10): CD004233. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F14651858.CD004233.pub4">10.1002/14651858.CD004233.pub4</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161494">4161494</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24150982">24150982</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Cochrane+Database+of+Systematic+Reviews&rft.atitle=Single+dose+oral+celecoxib+for+acute+postoperative+pain+in+adults&rft.volume=10&rft.issue=10&rft.pages=CD004233&rft.date=2013-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4161494%23id-name%3DPMC&rft_id=info%3Apmid%2F24150982&rft_id=info%3Adoi%2F10.1002%2F14651858.CD004233.pub4&rft.aulast=Derry&rft.aufirst=S&rft.au=Moore%2C+RA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4161494&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Yelland-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-Yelland_17-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYellandNiklesMcNairnDel_Mar2007" class="citation journal cs1">Yelland MJ, Nikles CJ, McNairn N, Del Mar CB, Schluter PJ, Brown RM (January 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Frheumatology%2Fkel195">"Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials"</a>. <i>Rheumatology</i>. <b>46</b> (1): <span class="nowrap">135–</span>40. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Frheumatology%2Fkel195">10.1093/rheumatology/kel195</a></span>. <a href="/wiki/Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://hdl.handle.net/10072%2F15035">10072/15035</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16777855">16777855</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Rheumatology&rft.atitle=Celecoxib+compared+with+sustained-release+paracetamol+for+osteoarthritis%3A+a+series+of+n-of-1+trials&rft.volume=46&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E135-%3C%2Fspan%3E40&rft.date=2007-01&rft_id=info%3Ahdl%2F10072%2F15035&rft_id=info%3Apmid%2F16777855&rft_id=info%3Adoi%2F10.1093%2Frheumatology%2Fkel195&rft.aulast=Yelland&rft.aufirst=MJ&rft.au=Nikles%2C+CJ&rft.au=McNairn%2C+N&rft.au=Del+Mar%2C+CB&rft.au=Schluter%2C+PJ&rft.au=Brown%2C+RM&rft_id=https%3A%2F%2Fdoi.org%2F10.1093%252Frheumatology%252Fkel195&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-OARSI2007-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-OARSI2007_18-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhangMoskowitzNukiAbramson2007" class="citation journal cs1">Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, et al. (September 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.joca.2007.06.014">"OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence"</a>. <i>Osteoarthritis and Cartilage</i>. <b>15</b> (9): <span class="nowrap">981–</span>1000. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.joca.2007.06.014">10.1016/j.joca.2007.06.014</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17719803">17719803</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Osteoarthritis+and+Cartilage&rft.atitle=OARSI+recommendations+for+the+management+of+hip+and+knee+osteoarthritis%2C+part+I%3A+critical+appraisal+of+existing+treatment+guidelines+and+systematic+review+of+current+research+evidence&rft.volume=15&rft.issue=9&rft.pages=%3Cspan+class%3D%22nowrap%22%3E981-%3C%2Fspan%3E1000&rft.date=2007-09&rft_id=info%3Adoi%2F10.1016%2Fj.joca.2007.06.014&rft_id=info%3Apmid%2F17719803&rft.aulast=Zhang&rft.aufirst=W&rft.au=Moskowitz%2C+RW&rft.au=Nuki%2C+G&rft.au=Abramson%2C+S&rft.au=Altman%2C+RD&rft.au=Arden%2C+N&rft.au=Bierma-Zeinstra%2C+S&rft.au=Brandt%2C+KD&rft.au=Croft%2C+P&rft.au=Doherty%2C+M&rft.au=Dougados%2C+M&rft.au=Hochberg%2C+M&rft.au=Hunter%2C+DJ&rft.au=Kwoh%2C+K&rft.au=Lohmander%2C+LS&rft.au=Tugwell%2C+P&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.joca.2007.06.014&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-19">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFlood2010" class="citation journal cs1">Flood J (March 2010). "The role of acetaminophen in the treatment of osteoarthritis". <i>The American Journal of Managed Care</i>. <b>16</b> (Suppl): S48–54. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20297877">20297877</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+American+Journal+of+Managed+Care&rft.atitle=The+role+of+acetaminophen+in+the+treatment+of+osteoarthritis&rft.volume=16&rft.issue=Suppl&rft.pages=S48-54&rft.date=2010-03&rft_id=info%3Apmid%2F20297877&rft.aulast=Flood&rft.aufirst=J&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-20">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPuljakMarinVrdoljakMarkotic2017" class="citation journal cs1">Puljak L, Marin A, Vrdoljak D, Markotic F, Utrobicic A, Tugwell P (May 2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481745">"Celecoxib for osteoarthritis"</a>. <i>The Cochrane Database of Systematic Reviews</i>. <b>5</b> (7): CD009865. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F14651858.CD009865.pub2">10.1002/14651858.CD009865.pub2</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481745">6481745</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28530031">28530031</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Cochrane+Database+of+Systematic+Reviews&rft.atitle=Celecoxib+for+osteoarthritis&rft.volume=5&rft.issue=7&rft.pages=CD009865&rft.date=2017-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6481745%23id-name%3DPMC&rft_id=info%3Apmid%2F28530031&rft_id=info%3Adoi%2F10.1002%2F14651858.CD009865.pub2&rft.aulast=Puljak&rft.aufirst=L&rft.au=Marin%2C+A&rft.au=Vrdoljak%2C+D&rft.au=Markotic%2C+F&rft.au=Utrobicic%2C+A&rft.au=Tugwell%2C+P&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6481745&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-21"><span class="mw-cite-backlink"><b><a href="#cite_ref-21">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSolomonMcMurrayPfefferWittes2005" class="citation journal cs1">Solomon SD, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, et al. (March 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa050405">"Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention"</a>. <i>The New England Journal of Medicine</i>. <b>352</b> (11): <span class="nowrap">1071–</span>80. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa050405">10.1056/NEJMoa050405</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15713944">15713944</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Cardiovascular+risk+associated+with+celecoxib+in+a+clinical+trial+for+colorectal+adenoma+prevention&rft.volume=352&rft.issue=11&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1071-%3C%2Fspan%3E80&rft.date=2005-03&rft_id=info%3Adoi%2F10.1056%2FNEJMoa050405&rft_id=info%3Apmid%2F15713944&rft.aulast=Solomon&rft.aufirst=SD&rft.au=McMurray%2C+JJ&rft.au=Pfeffer%2C+MA&rft.au=Wittes%2C+J&rft.au=Fowler%2C+R&rft.au=Finn%2C+P&rft.au=Anderson%2C+WF&rft.au=Zauber%2C+A&rft.au=Hawk%2C+E&rft.au=Bertagnolli%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.1056%252FNEJMoa050405&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-FDA_PR_20201015-22"><span class="mw-cite-backlink">^ <a href="#cite_ref-FDA_PR_20201015_22-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201015_22-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/news-events/press-announcements/fda-warns-using-type-pain-and-fever-medication-second-half-pregnancy-could-lead-complications">"FDA Warns that Using a Type of Pain and Fever Medication in Second Half of Pregnancy Could Lead to Complications"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i> (Press release). 15 October 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20201016180003/https://www.fda.gov/news-events/press-announcements/fda-warns-using-type-pain-and-fever-medication-second-half-pregnancy-could-lead-complications">Archived</a> from the original on 16 October 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">15 October</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=FDA+Warns+that+Using+a+Type+of+Pain+and+Fever+Medication+in+Second+Half+of+Pregnancy+Could+Lead+to+Complications&rft.date=2020-10-15&rft_id=https%3A%2F%2Fwww.fda.gov%2Fnews-events%2Fpress-announcements%2Ffda-warns-using-type-pain-and-fever-medication-second-half-pregnancy-could-lead-complications&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span> <span class="noviewer" typeof="mw:File"><span><img alt="Public Domain" src="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/12px-PD-icon.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/18px-PD-icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/24px-PD-icon.svg.png 2x" data-file-width="196" data-file-height="196" /></span></span> This article incorporates text from this source, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</span> </li> <li id="cite_note-FDA_safety_20201015-23"><span class="mw-cite-backlink">^ <a href="#cite_ref-FDA_safety_20201015_23-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-FDA_safety_20201015_23-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/drugs/drug-safety-and-availability/fda-recommends-avoiding-use-nsaids-pregnancy-20-weeks-or-later-because-they-can-result-low-amniotic">"NSAIDs may cause rare kidney problems in unborn babies"</a>. <i>U.S. Food and Drug Administration</i>. 21 July 2017. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20201017014419/https://www.fda.gov/drugs/drug-safety-and-availability/fda-recommends-avoiding-use-nsaids-pregnancy-20-weeks-or-later-because-they-can-result-low-amniotic">Archived</a> from the original on 17 October 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">15 October</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration&rft.atitle=NSAIDs+may+cause+rare+kidney+problems+in+unborn+babies&rft.date=2017-07-21&rft_id=https%3A%2F%2Fwww.fda.gov%2Fdrugs%2Fdrug-safety-and-availability%2Ffda-recommends-avoiding-use-nsaids-pregnancy-20-weeks-or-later-because-they-can-result-low-amniotic&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span> <span class="noviewer" typeof="mw:File"><span><img alt="Public Domain" src="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/12px-PD-icon.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/18px-PD-icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/24px-PD-icon.svg.png 2x" data-file-width="196" data-file-height="196" /></span></span> This article incorporates text from this source, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</span> </li> <li id="cite_note-NissenYeomans2016-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-NissenYeomans2016_24-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNissenYeomansSolomonLüscher2016" class="citation journal cs1">Nissen SE, Yeomans ND, Solomon DH, Lüscher TF, Libby P, Husni ME, et al. (December 2016). <a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa1611593">"Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis"</a>. <i>The New England Journal of Medicine</i>. <b>375</b> (26): <span class="nowrap">2519–</span>29. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa1611593">10.1056/NEJMoa1611593</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27959716">27959716</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Cardiovascular+Safety+of+Celecoxib%2C+Naproxen%2C+or+Ibuprofen+for+Arthritis&rft.volume=375&rft.issue=26&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2519-%3C%2Fspan%3E29&rft.date=2016-12&rft_id=info%3Adoi%2F10.1056%2FNEJMoa1611593&rft_id=info%3Apmid%2F27959716&rft.aulast=Nissen&rft.aufirst=SE&rft.au=Yeomans%2C+ND&rft.au=Solomon%2C+DH&rft.au=L%C3%BCscher%2C+TF&rft.au=Libby%2C+P&rft.au=Husni%2C+ME&rft.au=Graham%2C+DY&rft.au=Borer%2C+JS&rft.au=Wisniewski%2C+LM&rft.au=Wolski%2C+KE&rft.au=Wang%2C+Q&rft.au=Menon%2C+V&rft.au=Ruschitzka%2C+F&rft.au=Gaffney%2C+M&rft.au=Beckerman%2C+B&rft.au=Berger%2C+MF&rft.au=Bao%2C+W&rft.au=Lincoff%2C+AM&rft_id=https%3A%2F%2Fdoi.org%2F10.1056%252FNEJMoa1611593&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-pmid15684203-25"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid15684203_25-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKimmelBerlinReillyJaskowiak2005" class="citation journal cs1">Kimmel SE, Berlin JA, Reilly M, Jaskowiak J, Kishel L, Chittams J, et al. (February 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.7326%2F0003-4819-142-3-200502010-00005">"Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction"</a>. <i>Annals of Internal Medicine</i>. <b>142</b> (3): <span class="nowrap">157–</span>64. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.7326%2F0003-4819-142-3-200502010-00005">10.7326/0003-4819-142-3-200502010-00005</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15684203">15684203</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Annals+of+Internal+Medicine&rft.atitle=Patients+exposed+to+rofecoxib+and+celecoxib+have+different+odds+of+nonfatal+myocardial+infarction&rft.volume=142&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E157-%3C%2Fspan%3E64&rft.date=2005-02&rft_id=info%3Adoi%2F10.7326%2F0003-4819-142-3-200502010-00005&rft_id=info%3Apmid%2F15684203&rft.aulast=Kimmel&rft.aufirst=SE&rft.au=Berlin%2C+JA&rft.au=Reilly%2C+M&rft.au=Jaskowiak%2C+J&rft.au=Kishel%2C+L&rft.au=Chittams%2C+J&rft.au=Strom%2C+BL&rft_id=https%3A%2F%2Fdoi.org%2F10.7326%252F0003-4819-142-3-200502010-00005&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-pmid11509060-26"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11509060_26-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMukherjeeNissenTopol2001" class="citation journal cs1">Mukherjee D, Nissen SE, Topol EJ (2001). "Risk of cardiovascular events associated with selective COX-2 inhibitors". <i>JAMA</i>. <b>286</b> (8): <span class="nowrap">954–</span>9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Fjama.286.8.954">10.1001/jama.286.8.954</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11509060">11509060</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Risk+of+cardiovascular+events+associated+with+selective+COX-2+inhibitors&rft.volume=286&rft.issue=8&rft.pages=%3Cspan+class%3D%22nowrap%22%3E954-%3C%2Fspan%3E9&rft.date=2001&rft_id=info%3Adoi%2F10.1001%2Fjama.286.8.954&rft_id=info%3Apmid%2F11509060&rft.aulast=Mukherjee&rft.aufirst=D&rft.au=Nissen%2C+SE&rft.au=Topol%2C+EJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Jenkins-27"><span class="mw-cite-backlink"><b><a href="#cite_ref-Jenkins_27-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJenkinsSeligman2005" class="citation web cs1">Jenkins JK, Seligman PJ (6 April 2005). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20050909082236/https://www.fda.gov/cder/drug/infopage/cox2/NSAIDdecisionMemo.pdf">"Analysis and recommendations for Agency action regarding nonsteroidal anti-inflammatory drugs and cardiovascular risk [decision memorandum]"</a> <span class="cs1-format">(PDF)</span>. U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA). Archived from <a rel="nofollow" class="external text" href="https://www.fda.gov/cder/drug/infopage/cox2/NSAIDdecisionMemo.pdf">the original</a> <span class="cs1-format">(PDF)</span> on 9 September 2005.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Analysis+and+recommendations+for+Agency+action+regarding+nonsteroidal+anti-inflammatory+drugs+and+cardiovascular+risk+%5Bdecision+memorandum%5D&rft.pub=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.date=2005-04-06&rft.aulast=Jenkins&rft.aufirst=JK&rft.au=Seligman%2C+PJ&rft_id=https%3A%2F%2Fwww.fda.gov%2Fcder%2Fdrug%2Finfopage%2Fcox2%2FNSAIDdecisionMemo.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-pmid17176361-28"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid17176361_28-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFChenAshcroft2006" class="citation journal cs1">Chen LC, Ashcroft DM (December 2006). <a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-2710.2006.00774.x">"Do selective COX-2 inhibitors increase the risk of cerebrovascular events? A meta-analysis of randomized controlled trials"</a>. <i>Journal of Clinical Pharmacy and Therapeutics</i>. <b>31</b> (6): <span class="nowrap">565–</span>76. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-2710.2006.00774.x">10.1111/j.1365-2710.2006.00774.x</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17176361">17176361</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:40738580">40738580</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacy+and+Therapeutics&rft.atitle=Do+selective+COX-2+inhibitors+increase+the+risk+of+cerebrovascular+events%3F+A+meta-analysis+of+randomized+controlled+trials&rft.volume=31&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E565-%3C%2Fspan%3E76&rft.date=2006-12&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A40738580%23id-name%3DS2CID&rft_id=info%3Apmid%2F17176361&rft_id=info%3Adoi%2F10.1111%2Fj.1365-2710.2006.00774.x&rft.aulast=Chen&rft.aufirst=LC&rft.au=Ashcroft%2C+DM&rft_id=https%3A%2F%2Fdoi.org%2F10.1111%252Fj.1365-2710.2006.00774.x&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Shkundin_2025-29"><span class="mw-cite-backlink">^ <a href="#cite_ref-Shkundin_2025_29-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Shkundin_2025_29-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Shkundin_2025_29-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFShkundinWheelerSinacoreHalaris2025" class="citation journal cs1">Shkundin A, Wheeler HE, Sinacore J, Halaris A (2025). <a rel="nofollow" class="external text" href="https://doi.org/10.3390%2Fjpm15020062">"BDNF/BDNF-AS Gene Polymorphisms Modulate Treatment Response and Remission in Bipolar Disorder: A Randomized Clinical Trial"</a>. <i>Journal of Personalized Medicine</i>. <b>15</b> (2): 62. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3390%2Fjpm15020062">10.3390/jpm15020062</a></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Personalized+Medicine&rft.atitle=BDNF%2FBDNF-AS+Gene+Polymorphisms+Modulate+Treatment+Response+and+Remission+in+Bipolar+Disorder%3A+A+Randomized+Clinical+Trial&rft.volume=15&rft.issue=2&rft.pages=62&rft.date=2025&rft_id=info%3Adoi%2F10.3390%2Fjpm15020062&rft.aulast=Shkundin&rft.aufirst=A&rft.au=Wheeler%2C+HE&rft.au=Sinacore%2C+J&rft.au=Halaris%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.3390%252Fjpm15020062&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-30"><span class="mw-cite-backlink"><b><a href="#cite_ref-30">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTurnerMayArthurXiong2007" class="citation journal cs1">Turner MS, May DB, Arthur RR, Xiong GL (March 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-2796.2006.01720.x">"Clinical impact of selective serotonin reuptake inhibitors therapy with bleeding risks"</a>. <i>Journal of Internal Medicine</i>. <b>261</b> (3): <span class="nowrap">205–</span>213. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-2796.2006.01720.x">10.1111/j.1365-2796.2006.01720.x</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17305643">17305643</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:41772614">41772614</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Internal+Medicine&rft.atitle=Clinical+impact+of+selective+serotonin+reuptake+inhibitors+therapy+with+bleeding+risks&rft.volume=261&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E205-%3C%2Fspan%3E213&rft.date=2007-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A41772614%23id-name%3DS2CID&rft_id=info%3Apmid%2F17305643&rft_id=info%3Adoi%2F10.1111%2Fj.1365-2796.2006.01720.x&rft.aulast=Turner&rft.aufirst=MS&rft.au=May%2C+DB&rft.au=Arthur%2C+RR&rft.au=Xiong%2C+GL&rft_id=https%3A%2F%2Fdoi.org%2F10.1111%252Fj.1365-2796.2006.01720.x&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Mathew-31"><span class="mw-cite-backlink">^ <a href="#cite_ref-Mathew_31-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Mathew_31-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMathewDeviPrasanthVinod2011" class="citation journal cs1">Mathew ST, Devi SG, Prasanth VV, Vinod B (2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197256">"Efficacy and Safety of COX-2 Inhibitors in the Clinical Management of Arthritis: Mini Review"</a>. <i>ISRN Pharmacology</i>. <b>2011</b>: 480291. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.5402%2F2011%2F480291">10.5402/2011/480291</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197256">3197256</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22084715">22084715</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=ISRN+Pharmacology&rft.atitle=Efficacy+and+Safety+of+COX-2+Inhibitors+in+the+Clinical+Management+of+Arthritis%3A+Mini+Review&rft.volume=2011&rft.pages=480291&rft.date=2011&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3197256%23id-name%3DPMC&rft_id=info%3Apmid%2F22084715&rft_id=info%3Adoi%2F10.5402%2F2011%2F480291&rft.aulast=Mathew&rft.aufirst=ST&rft.au=Devi%2C+SG&rft.au=Prasanth%2C+VV&rft.au=Vinod%2C+B&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3197256&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Katzung-32"><span class="mw-cite-backlink">^ <a href="#cite_ref-Katzung_32-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Katzung_32-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKatzung2007" class="citation book cs1">Katzung BG (2007). <i>Basic & clinical pharmacology</i> (10th ed.). New York: McGraw-Hill Medical. p. 579. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780071451536" title="Special:BookSources/9780071451536"><bdi>9780071451536</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Basic+%26+clinical+pharmacology&rft.place=New+York&rft.pages=579&rft.edition=10th&rft.pub=McGraw-Hill+Medical&rft.date=2007&rft.isbn=9780071451536&rft.aulast=Katzung&rft.aufirst=BG&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Shi_S_and_Koltz_U-33"><span class="mw-cite-backlink"><b><a href="#cite_ref-Shi_S_and_Koltz_U_33-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFShiKlotz2008" class="citation journal cs1">Shi S, Klotz U (March 2008). "Clinical use and pharmacological properties of selective COX-2 inhibitors". <i>European Journal of Clinical Pharmacology</i>. <b>64</b> (3): <span class="nowrap">233–</span>52. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00228-007-0400-7">10.1007/s00228-007-0400-7</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17999057">17999057</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:24063728">24063728</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Pharmacology&rft.atitle=Clinical+use+and+pharmacological+properties+of+selective+COX-2+inhibitors&rft.volume=64&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E233-%3C%2Fspan%3E52&rft.date=2008-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A24063728%23id-name%3DS2CID&rft_id=info%3Apmid%2F17999057&rft_id=info%3Adoi%2F10.1007%2Fs00228-007-0400-7&rft.aulast=Shi&rft.aufirst=S&rft.au=Klotz%2C+U&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-34"><span class="mw-cite-backlink"><b><a href="#cite_ref-34">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFConaghan2012" class="citation journal cs1">Conaghan PG (June 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364420">"A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity"</a>. <i>Rheumatology International</i>. <b>32</b> (6): <span class="nowrap">1491–</span>502. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00296-011-2263-6">10.1007/s00296-011-2263-6</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364420">3364420</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22193214">22193214</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Rheumatology+International&rft.atitle=A+turbulent+decade+for+NSAIDs%3A+update+on+current+concepts+of+classification%2C+epidemiology%2C+comparative+efficacy%2C+and+toxicity&rft.volume=32&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1491-%3C%2Fspan%3E502&rft.date=2012-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3364420%23id-name%3DPMC&rft_id=info%3Apmid%2F22193214&rft_id=info%3Adoi%2F10.1007%2Fs00296-011-2263-6&rft.aulast=Conaghan&rft.aufirst=PG&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3364420&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-DiPiro_2008-35"><span class="mw-cite-backlink"><b><a href="#cite_ref-DiPiro_2008_35-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDipiroTalbertYeeMatzke2008" class="citation book cs1">Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM (2008). <i>Pharmacotherapy A Pathophysiologic Approach</i> (7th ed.). New York: McGraw-Hill Medical. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-07-147899-1" title="Special:BookSources/978-0-07-147899-1"><bdi>978-0-07-147899-1</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Pharmacotherapy+A+Pathophysiologic+Approach&rft.place=New+York&rft.edition=7th&rft.pub=McGraw-Hill+Medical&rft.date=2008&rft.isbn=978-0-07-147899-1&rft.aulast=Dipiro&rft.aufirst=JT&rft.au=Talbert%2C+RL&rft.au=Yee%2C+GC&rft.au=Matzke%2C+GR&rft.au=Wells%2C+BG&rft.au=Posey%2C+LM&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-36"><span class="mw-cite-backlink"><b><a href="#cite_ref-36">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBhattScheimanAbrahamAntman2008" class="citation journal cs1">Bhatt DL, Scheiman J, Abraham NS, Antman EM, Chan FK, Furberg CD, et al. (October 2008). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jacc.2008.08.002">"ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents"</a>. <i>Journal of the American College of Cardiology</i>. <b>52</b> (18): <span class="nowrap">1502–</span>17. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jacc.2008.08.002">10.1016/j.jacc.2008.08.002</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19017521">19017521</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=ACCF%2FACG%2FAHA+2008+expert+consensus+document+on+reducing+the+gastrointestinal+risks+of+antiplatelet+therapy+and+NSAID+use%3A+a+report+of+the+American+College+of+Cardiology+Foundation+Task+Force+on+Clinical+Expert+Consensus+Documents&rft.volume=52&rft.issue=18&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1502-%3C%2Fspan%3E17&rft.date=2008-10&rft_id=info%3Adoi%2F10.1016%2Fj.jacc.2008.08.002&rft_id=info%3Apmid%2F19017521&rft.aulast=Bhatt&rft.aufirst=DL&rft.au=Scheiman%2C+J&rft.au=Abraham%2C+NS&rft.au=Antman%2C+EM&rft.au=Chan%2C+FK&rft.au=Furberg%2C+CD&rft.au=Johnson%2C+DA&rft.au=Mahaffey%2C+KW&rft.au=Quigley%2C+EM&rft.au=Harrington%2C+RA&rft.au=Bates%2C+ER&rft.au=Bridges%2C+CR&rft.au=Eisenberg%2C+MJ&rft.au=Ferrari%2C+VA&rft.au=Hlatky%2C+MA&rft.au=Kaul%2C+S&rft.au=Lindner%2C+JR&rft.au=Moliterno%2C+DJ&rft.au=Mukherjee%2C+D&rft.au=Schofield%2C+RS&rft.au=Rosenson%2C+RS&rft.au=Stein%2C+JH&rft.au=Weitz%2C+HH&rft.au=Wesley%2C+DJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.jacc.2008.08.002&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-37"><span class="mw-cite-backlink"><b><a href="#cite_ref-37">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHalfArber2009" class="citation journal cs1">Half E, Arber N (February 2009). "Colon cancer: preventive agents and the present status of chemoprevention". <i>Expert Opinion on Pharmacotherapy</i>. <b>10</b> (2): <span class="nowrap">211–</span>9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1517%2F14656560802560153">10.1517/14656560802560153</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19236194">19236194</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:72411967">72411967</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Pharmacotherapy&rft.atitle=Colon+cancer%3A+preventive+agents+and+the+present+status+of+chemoprevention&rft.volume=10&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E211-%3C%2Fspan%3E9&rft.date=2009-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A72411967%23id-name%3DS2CID&rft_id=info%3Apmid%2F19236194&rft_id=info%3Adoi%2F10.1517%2F14656560802560153&rft.aulast=Half&rft.aufirst=E&rft.au=Arber%2C+N&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Penning-38"><span class="mw-cite-backlink">^ <a href="#cite_ref-Penning_38-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Penning_38-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Penning_38-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPenningTalleyBertenshawCarter1997" class="citation journal cs1">Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, et al. (April 1997). "Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib)". <i>Journal of Medicinal Chemistry</i>. <b>40</b> (9): <span class="nowrap">1347–</span>65. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Fjm960803q">10.1021/jm960803q</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9135032">9135032</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Synthesis+and+biological+evaluation+of+the+1%2C5-diarylpyrazole+class+of+cyclooxygenase-2+inhibitors%3A+identification+of+4-%5B5-%284-methylphenyl%29-3-%28trifluoromethyl%29-1H-pyrazol-1-yl%5Dbenze+nesulfonamide+%28SC-58635%2C+celecoxib%29&rft.volume=40&rft.issue=9&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1347-%3C%2Fspan%3E65&rft.date=1997-04&rft_id=info%3Adoi%2F10.1021%2Fjm960803q&rft_id=info%3Apmid%2F9135032&rft.aulast=Penning&rft.aufirst=TD&rft.au=Talley%2C+JJ&rft.au=Bertenshaw%2C+SR&rft.au=Carter%2C+JS&rft.au=Collins%2C+PW&rft.au=Docter%2C+S&rft.au=Graneto%2C+MJ&rft.au=Lee%2C+LF&rft.au=Malecha%2C+JW&rft.au=Miyashiro%2C+JM&rft.au=Rogers%2C+RS&rft.au=Rogier%2C+DJ&rft.au=Yu%2C+SS&rft.au=Burton%2C+EG&rft.au=Cogburn%2C+JN&rft.au=Gregory%2C+SA&rft.au=Koboldt%2C+CM&rft.au=Perkins%2C+WE&rft.au=Seibert%2C+K&rft.au=Veenhuizen%2C+AW&rft.au=Zhang%2C+YY&rft.au=Isakson%2C+PC&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Price-39"><span class="mw-cite-backlink">^ <a href="#cite_ref-Price_39-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Price_39-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPriceJorgensen2001" class="citation journal cs1">Price ML, Jorgensen WL (June 2001). "Rationale for the observed COX-2/COX-1 selectivity of celecoxib from Monte Carlo simulations". <i>Bioorganic & Medicinal Chemistry Letters</i>. <b>11</b> (12): <span class="nowrap">1541–</span>4. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs0960-894x%2800%2900522-9">10.1016/s0960-894x(00)00522-9</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11412976">11412976</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Bioorganic+%26+Medicinal+Chemistry+Letters&rft.atitle=Rationale+for+the+observed+COX-2%2FCOX-1+selectivity+of+celecoxib+from+Monte+Carlo+simulations&rft.volume=11&rft.issue=12&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1541-%3C%2Fspan%3E4&rft.date=2001-06&rft_id=info%3Adoi%2F10.1016%2Fs0960-894x%2800%2900522-9&rft_id=info%3Apmid%2F11412976&rft.aulast=Price&rft.aufirst=ML&rft.au=Jorgensen%2C+WL&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Forbes2003-40"><span class="mw-cite-backlink"><b><a href="#cite_ref-Forbes2003_40-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLangreth2003" class="citation news cs1">Langreth R (23 June 2003). <a rel="nofollow" class="external text" href="https://www.forbes.com/global/2003/0623/050.html">"The Chemical Cobbler"</a>. <i>Forbes</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180416013759/https://www.forbes.com/global/2003/0623/050.html">Archived</a> from the original on 16 April 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">15 April</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Forbes&rft.atitle=The+Chemical+Cobbler&rft.date=2003-06-23&rft.aulast=Langreth&rft.aufirst=R&rft_id=https%3A%2F%2Fwww.forbes.com%2Fglobal%2F2003%2F0623%2F050.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-SLACS-41"><span class="mw-cite-backlink"><b><a href="#cite_ref-SLACS_41-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation journal cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20180415180802/http://www.stlacs.org/Bonds/2001May.pdf">"Dr. John Talley: 2001 St. Louis Awardee"</a> <span class="cs1-format">(PDF)</span>. <i>Chemical Bond</i>. <b>52</b> (5): 2. May 2001. Archived from <a rel="nofollow" class="external text" href="http://www.stlacs.org/Bonds/2001May.pdf">the original</a> <span class="cs1-format">(PDF)</span> on 15 April 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Chemical+Bond&rft.atitle=Dr.+John+Talley%3A+2001+St.+Louis+Awardee&rft.volume=52&rft.issue=5&rft.pages=2&rft.date=2001-05&rft_id=http%3A%2F%2Fwww.stlacs.org%2FBonds%2F2001May.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-ScientistBYULitig-42"><span class="mw-cite-backlink"><b><a href="#cite_ref-ScientistBYULitig_42-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYajnik_J2006" class="citation web cs1">Yajnik J (27 October 2006). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20090203140727/http://www.the-scientist.com/news/display/25408/">"University sues Pfizer over COX-2 research"</a>. <i><a href="/wiki/The_Scientist_(magazine)" title="The Scientist (magazine)">The Scientist</a></i>. Archived from <a rel="nofollow" class="external text" href="http://www.the-scientist.com/news/display/25408/">the original</a> on 3 February 2009<span class="reference-accessdate">. Retrieved <span class="nowrap">11 November</span> 2010</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=The+Scientist&rft.atitle=University+sues+Pfizer+over+COX-2+research&rft.date=2006-10-27&rft.au=Yajnik+J&rft_id=http%3A%2F%2Fwww.the-scientist.com%2Fnews%2Fdisplay%2F25408%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Deseret_News-43"><span class="mw-cite-backlink"><b><a href="#cite_ref-Deseret_News_43-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLinda_Thomson2009" class="citation web cs1">Linda Thomson (28 October 2009). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20091031124503/http://www.deseretnews.com/article/705340277/Judge-orders-Pfizer-to-pay-BYU-852K-for-suit-delays.html">"Judge orders Pfizer to pay BYU $852K for suit delays"</a>. <i>Deseret News</i>. Archived from <a rel="nofollow" class="external text" href="http://www.deseretnews.com/article/705340277/Judge-orders-Pfizer-to-pay-BYU-852K-for-suit-delays.html">the original</a> on 31 October 2009<span class="reference-accessdate">. Retrieved <span class="nowrap">23 November</span> 2009</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Deseret+News&rft.atitle=Judge+orders+Pfizer+to+pay+BYU+%24852K+for+suit+delays&rft.date=2009-10-28&rft.au=Linda+Thomson&rft_id=http%3A%2F%2Fwww.deseretnews.com%2Farticle%2F705340277%2FJudge-orders-Pfizer-to-pay-BYU-852K-for-suit-delays.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Settlement-44"><span class="mw-cite-backlink"><b><a href="#cite_ref-Settlement_44-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHarvey2012" class="citation news cs1">Harvey T (1 May 2012). <a rel="nofollow" class="external text" href="http://www.sltrib.com/sltrib/entertainment/54024947-79/byu-pfizer-settlement-simmons.html.csp">"Pfizer, BYU settle Celebrex lawsuit for $450M"</a>. <i><a href="/wiki/The_Salt_Lake_Tribune" title="The Salt Lake Tribune">The Salt Lake Tribune</a></i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160303220047/http://www.sltrib.com/sltrib/entertainment/54024947-79/byu-pfizer-settlement-simmons.html.csp">Archived</a> from the original on 3 March 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">22 July</span> 2012</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Salt+Lake+Tribune&rft.atitle=Pfizer%2C+BYU+settle+Celebrex+lawsuit+for+%24450M&rft.date=2012-05-01&rft.aulast=Harvey&rft.aufirst=T&rft_id=http%3A%2F%2Fwww.sltrib.com%2Fsltrib%2Fentertainment%2F54024947-79%2Fbyu-pfizer-settlement-simmons.html.csp&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-45"><span class="mw-cite-backlink"><b><a href="#cite_ref-45">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation news cs1"><a rel="nofollow" class="external text" href="https://www.nytimes.com/2012/05/02/health/pfizer-settles-byu-lawsuit-over-development-of-celebrex.html">"Pfizer Settles B.Y.U. Lawsuit Over Development of Celebrex"</a>. <i><a href="/wiki/The_New_York_Times" title="The New York Times">The New York Times</a></i>. <a href="/wiki/Associated_Press" title="Associated Press">Associated Press</a>. 1 May 2012. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20171227132546/http://www.nytimes.com/2012/05/02/health/pfizer-settles-byu-lawsuit-over-development-of-celebrex.html">Archived</a> from the original on 27 December 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">5 May</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+York+Times&rft.atitle=Pfizer+Settles+B.Y.U.+Lawsuit+Over+Development+of+Celebrex&rft.date=2012-05-01&rft_id=https%3A%2F%2Fwww.nytimes.com%2F2012%2F05%2F02%2Fhealth%2Fpfizer-settles-byu-lawsuit-over-development-of-celebrex.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-46"><span class="mw-cite-backlink"><b><a href="#cite_ref-46">^</a></b></span> <span class="reference-text"><span><a rel="nofollow" class="external text" href="https://patents.google.com/patent/US6048850">U.S. patent 6,048,850</a></span></span> </li> <li id="cite_note-hodgsonruss-47"><span class="mw-cite-backlink">^ <a href="#cite_ref-hodgsonruss_47-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-hodgsonruss_47-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.hodgsonruss.com/Home/Practice_Areas/Alphabetical_Listing/Intellectual_Property_Technology/Articles/20012004Articles/Reach-ThroughClaimsDeclaredInvalid">"Reach-Through Claims Declared Invalid"</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20140222060537/http://www.hodgsonruss.com/Home/Practice_Areas/Alphabetical_Listing/Intellectual_Property_Technology/Articles/20012004Articles/Reach-ThroughClaimsDeclaredInvalid">Archived</a> from the original on 22 February 2014<span class="reference-accessdate">. Retrieved <span class="nowrap">31 December</span> 2012</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Reach-Through+Claims+Declared+Invalid&rft_id=http%3A%2F%2Fwww.hodgsonruss.com%2FHome%2FPractice_Areas%2FAlphabetical_Listing%2FIntellectual_Property_Technology%2FArticles%2F20012004Articles%2FReach-ThroughClaimsDeclaredInvalid&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-kayescholer-48"><span class="mw-cite-backlink">^ <a href="#cite_ref-kayescholer_48-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-kayescholer_48-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text">Ranjana Kadle (2004) <a rel="nofollow" class="external text" href="https://web.archive.org/web/20130721100341/http://www.kayescholer.com/professionals/sobel_gerald_extras/misc/01_Rochester2_FedCir_Affirm.pdf">CAFC Court Decision Reach-Through Claims Declared Invalid</a></span> </li> <li id="cite_note-NASO-49"><span class="mw-cite-backlink">^ <a href="#cite_ref-NASO_49-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-NASO_49-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-NASO_49-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.nasonline.org/news-and-multimedia/podcasts/interviews/philip-needleman.html?referrer=https://www.google.ca/">"Philip Needleman"</a>. National Academy of Sciences. 15 June 2015. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160107133428/http://www.nasonline.org/news-and-multimedia/podcasts/interviews/philip-needleman.html?referrer=https%3A%2F%2Fwww.google.ca%2F">Archived</a> from the original on 7 January 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">28 December</span> 2015</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Philip+Needleman&rft.pub=National+Academy+of+Sciences&rft.date=2015-06-15&rft_id=http%3A%2F%2Fwww.nasonline.org%2Fnews-and-multimedia%2Fpodcasts%2Finterviews%2Fphilip-needleman.html%3Freferrer%3Dhttps%3A%2F%2Fwww.google.ca%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-50"><span class="mw-cite-backlink"><b><a href="#cite_ref-50">^</a></b></span> <span class="reference-text"><span><a rel="nofollow" class="external text" href="https://patents.google.com/patent/US5466823">U.S. patent 5,466,823</a></span></span> </li> <li id="cite_note-51"><span class="mw-cite-backlink"><b><a href="#cite_ref-51">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.accessdata.fda.gov/drugsatfda_docs/nda/98/20998.cfm">"Drug Approval Package: Celebrex (Celecoxib) NDA# 20-998"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>. 24 December 1999. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190327103438/https://www.accessdata.fda.gov/drugsatfda_docs/nda/98/20998.cfm">Archived</a> from the original on 27 March 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">5 May</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=Drug+Approval+Package%3A+Celebrex+%28Celecoxib%29+NDA%23+20-998&rft.date=1999-12-24&rft_id=https%3A%2F%2Fwww.accessdata.fda.gov%2Fdrugsatfda_docs%2Fnda%2F98%2F20998.cfm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-NYT2012-52"><span class="mw-cite-backlink">^ <a href="#cite_ref-NYT2012_52-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-NYT2012_52-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-NYT2012_52-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-NYT2012_52-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-NYT2012_52-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-NYT2012_52-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-NYT2012_52-6"><sup><i><b>g</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFThomas2012" class="citation news cs1">Thomas K (24 June 2012). <a rel="nofollow" class="external text" href="https://www.nytimes.com/2012/06/25/health/in-documents-on-pain-drug-celebrex-signs-of-doubt-and-deception.html">"In Documents on Pain Drug, Signs of Doubt and Deception"</a>. <i><a href="/wiki/The_New_York_Times" title="The New York Times">The New York Times</a></i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160103151323/http://www.nytimes.com/2012/06/25/health/in-documents-on-pain-drug-celebrex-signs-of-doubt-and-deception.html">Archived</a> from the original on 3 January 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">27 December</span> 2015</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+York+Times&rft.atitle=In+Documents+on+Pain+Drug%2C+Signs+of+Doubt+and+Deception&rft.date=2012-06-24&rft.aulast=Thomas&rft.aufirst=K&rft_id=https%3A%2F%2Fwww.nytimes.com%2F2012%2F06%2F25%2Fhealth%2Fin-documents-on-pain-drug-celebrex-signs-of-doubt-and-deception.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Berenson-53"><span class="mw-cite-backlink"><b><a href="#cite_ref-Berenson_53-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBerenson_A2006" class="citation news cs1">Berenson A (29 April 2006). <a rel="nofollow" class="external text" href="https://www.nytimes.com/2006/04/29/business/media/29celebrex.html">"Celebrex Ads Are Back, Dire Warnings and All"</a>. <i>The New York Times</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160107133428/http://www.nytimes.com/2006/04/29/business/media/29celebrex.html">Archived</a> from the original on 7 January 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">21 February</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+York+Times&rft.atitle=Celebrex+Ads+Are+Back%2C+Dire+Warnings+and+All&rft.date=2006-04-29&rft.au=Berenson+A&rft_id=https%3A%2F%2Fwww.nytimes.com%2F2006%2F04%2F29%2Fbusiness%2Fmedia%2F29celebrex.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Saul-54"><span class="mw-cite-backlink">^ <a href="#cite_ref-Saul_54-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Saul_54-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSaul_S2007" class="citation news cs1">Saul S (10 April 2007). <a rel="nofollow" class="external text" href="https://www.nytimes.com/2007/04/10/business/media/10celebrex.html">"Celebrex Commercial, Long and Unconventional, Draws Criticism"</a>. <i>The New York Times</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180117060825/http://www.nytimes.com/2007/04/10/business/media/10celebrex.html">Archived</a> from the original on 17 January 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">21 February</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+York+Times&rft.atitle=Celebrex+Commercial%2C+Long+and+Unconventional%2C+Draws+Criticism&rft.date=2007-04-10&rft.au=Saul+S&rft_id=https%3A%2F%2Fwww.nytimes.com%2F2007%2F04%2F10%2Fbusiness%2Fmedia%2F10celebrex.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-nyt0311-55"><span class="mw-cite-backlink"><b><a href="#cite_ref-nyt0311_55-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHarris2009" class="citation news cs1">Harris G (11 March 2009). <a rel="nofollow" class="external text" href="https://www.nytimes.com/2009/03/11/health/research/11pain.html">"Doctor Admits Pain Studies Were Frauds, Hospital Says"</a>. <i><a href="/wiki/The_New_York_Times" title="The New York Times">The New York Times</a></i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170517184147/http://www.nytimes.com/2009/03/11/health/research/11pain.html">Archived</a> from the original on 17 May 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">27 December</span> 2015</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+York+Times&rft.atitle=Doctor+Admits+Pain+Studies+Were+Frauds%2C+Hospital+Says&rft.date=2009-03-11&rft.aulast=Harris&rft.aufirst=G&rft_id=https%3A%2F%2Fwww.nytimes.com%2F2009%2F03%2F11%2Fhealth%2Fresearch%2F11pain.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-WSJ-3-2009-56"><span class="mw-cite-backlink"><b><a href="#cite_ref-WSJ-3-2009_56-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWinstein2009" class="citation news cs1">Winstein KJ (11 March 2009). <span class="id-lock-subscription" title="Paid subscription required"><a rel="nofollow" class="external text" href="https://www.wsj.com/articles/SB123672510903888207">"Top Pain Scientist Fabricated Data in Studies, Hospital Says"</a></span>. <i><a href="/wiki/The_Wall_Street_Journal" title="The Wall Street Journal">The Wall Street Journal</a></i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170830223401/https://www.wsj.com/articles/SB123672510903888207">Archived</a> from the original on 30 August 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">3 August</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Wall+Street+Journal&rft.atitle=Top+Pain+Scientist+Fabricated+Data+in+Studies%2C+Hospital+Says&rft.date=2009-03-11&rft.aulast=Winstein&rft.aufirst=KJ&rft_id=https%3A%2F%2Fwww.wsj.com%2Farticles%2FSB123672510903888207&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-57"><span class="mw-cite-backlink"><b><a href="#cite_ref-57">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20090316103119/https://www.google.com/hostednews/ap/article/ALeqM5jjpBsTFN9SEtQu-xyDltivC2GJ8AD96S2KVO0">"Associated Press, Mar 11, 2009, <i>Mass. doctor accused of faking pain pill data</i>"</a>. Archived from <a rel="nofollow" class="external text" href="https://www.google.com/hostednews/ap/article/ALeqM5jjpBsTFN9SEtQu-xyDltivC2GJ8AD96S2KVO0">the original</a> on 16 March 2009.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Associated+Press%2C+Mar+11%2C+2009%2C+Mass.+doctor+accused+of+faking+pain+pill+data&rft_id=https%3A%2F%2Fwww.google.com%2Fhostednews%2Fap%2Farticle%2FALeqM5jjpBsTFN9SEtQu-xyDltivC2GJ8AD96S2KVO0&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-58"><span class="mw-cite-backlink"><b><a href="#cite_ref-58">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/international/celecoxib.html">"Celecoxib"</a>. <i>Drugs.com</i>. 4 May 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160310184046/http://www.drugs.com/international/celecoxib.html">Archived</a> from the original on 10 March 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">5 May</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drugs.com&rft.atitle=Celecoxib&rft.date=2020-05-04&rft_id=https%3A%2F%2Fwww.drugs.com%2Finternational%2Fcelecoxib.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-59"><span class="mw-cite-backlink"><b><a href="#cite_ref-59">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://patents.google.com/patent/USRE44048">"US Re-issued Patent RE44048"</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170109190350/https://www.google.com/patents/USRE44048">Archived</a> from the original on 9 January 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">10 November</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=US+Re-issued+Patent+RE44048&rft_id=https%3A%2F%2Fpatents.google.com%2Fpatent%2FUSRE44048&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-60"><span class="mw-cite-backlink"><b><a href="#cite_ref-60">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFParloff2014" class="citation web cs1">Parloff R (13 March 2014). <a rel="nofollow" class="external text" href="https://fortune.com/2014/03/13/judge-cuts-18-months-off-patent-life-of-pfizers-celebrex/">"Judge cuts 18 months off patent life of Pfizer's Celebrex"</a>. <i><a href="/wiki/Fortune_(magazine)" title="Fortune (magazine)">Fortune</a></i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170725162355/http://fortune.com/2014/03/13/judge-cuts-18-months-off-patent-life-of-pfizers-celebrex/">Archived</a> from the original on 25 July 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">5 May</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Fortune&rft.atitle=Judge+cuts+18+months+off+patent+life+of+Pfizer%27s+Celebrex&rft.date=2014-03-13&rft.aulast=Parloff&rft.aufirst=R&rft_id=https%3A%2F%2Ffortune.com%2F2014%2F03%2F13%2Fjudge-cuts-18-months-off-patent-life-of-pfizers-celebrex%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-61"><span class="mw-cite-backlink"><b><a href="#cite_ref-61">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20140531020104/https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm399428.htm">"FDA approves first generic versions of celecoxib"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i> (Press release). 31 May 2014. Archived from <a rel="nofollow" class="external text" href="https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm399428.htm">the original</a> on 31 May 2014<span class="reference-accessdate">. Retrieved <span class="nowrap">5 May</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=FDA+approves+first+generic+versions+of+celecoxib&rft.date=2014-05-31&rft_id=https%3A%2F%2Fwww.fda.gov%2Fnewsevents%2Fnewsroom%2Fpressannouncements%2Fucm399428.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-62"><span class="mw-cite-backlink"><b><a href="#cite_ref-62">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.businesswire.com/news/home/20201116005378/en/">"Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan"</a>. Pfizer. 16 November 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">17 June</span> 2024</span> – via Business Wire.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Pfizer+Completes+Transaction+to+Combine+Its+Upjohn+Business+with+Mylan&rft.pub=Pfizer&rft.date=2020-11-16&rft_id=https%3A%2F%2Fwww.businesswire.com%2Fnews%2Fhome%2F20201116005378%2Fen%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-63"><span class="mw-cite-backlink"><b><a href="#cite_ref-63">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.pfizer.com/products/product-detail/celebrex">"Celebrex"</a>. <i>Pfizer</i><span class="reference-accessdate">. Retrieved <span class="nowrap">17 June</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Pfizer&rft.atitle=Celebrex&rft_id=https%3A%2F%2Fwww.pfizer.com%2Fproducts%2Fproduct-detail%2Fcelebrex&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-64"><span class="mw-cite-backlink"><b><a href="#cite_ref-64">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.viatris.com/en/products/brands">"Brands"</a>. <i>Viatris</i>. 16 November 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">17 June</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Viatris&rft.atitle=Brands&rft.date=2020-11-16&rft_id=https%3A%2F%2Fwww.viatris.com%2Fen%2Fproducts%2Fbrands&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-repurposed2021-65"><span class="mw-cite-backlink">^ <a href="#cite_ref-repurposed2021_65-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-repurposed2021_65-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBartoliCavaleriBachiMoretti2021" class="citation journal cs1">Bartoli F, Cavaleri D, Bachi B, Moretti F, Riboldi I, Crocamo C, et al. (September 2021). "Repurposed drugs as adjunctive treatments for mania and bipolar depression: A meta-review and critical appraisal of meta-analyses of randomized placebo-controlled trials". <i>Journal of Psychiatric Research</i>. <b>143</b>: <span class="nowrap">230–</span>238. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jpsychires.2021.09.018">10.1016/j.jpsychires.2021.09.018</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/34509090">34509090</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:237485915">237485915</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Repurposed+drugs+as+adjunctive+treatments+for+mania+and+bipolar+depression%3A+A+meta-review+and+critical+appraisal+of+meta-analyses+of+randomized+placebo-controlled+trials&rft.volume=143&rft.pages=%3Cspan+class%3D%22nowrap%22%3E230-%3C%2Fspan%3E238&rft.date=2021-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A237485915%23id-name%3DS2CID&rft_id=info%3Apmid%2F34509090&rft_id=info%3Adoi%2F10.1016%2Fj.jpsychires.2021.09.018&rft.aulast=Bartoli&rft.aufirst=F&rft.au=Cavaleri%2C+D&rft.au=Bachi%2C+B&rft.au=Moretti%2C+F&rft.au=Riboldi%2C+I&rft.au=Crocamo%2C+C&rft.au=Carr%C3%A0%2C+G&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-66"><span class="mw-cite-backlink"><b><a href="#cite_ref-66">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMüllerMyintKrauseWeidinger2013" class="citation journal cs1">Müller N, Myint AM, Krause D, Weidinger E, Schwarz MJ (April 2013). "Anti-inflammatory treatment in schizophrenia". <i>Progress in Neuro-Psychopharmacology & Biological Psychiatry</i>. <b>42</b>: <span class="nowrap">146–</span>53. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pnpbp.2012.11.008">10.1016/j.pnpbp.2012.11.008</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23178230">23178230</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:22078590">22078590</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Progress+in+Neuro-Psychopharmacology+%26+Biological+Psychiatry&rft.atitle=Anti-inflammatory+treatment+in+schizophrenia&rft.volume=42&rft.pages=%3Cspan+class%3D%22nowrap%22%3E146-%3C%2Fspan%3E53&rft.date=2013-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A22078590%23id-name%3DS2CID&rft_id=info%3Apmid%2F23178230&rft_id=info%3Adoi%2F10.1016%2Fj.pnpbp.2012.11.008&rft.aulast=M%C3%BCller&rft.aufirst=N&rft.au=Myint%2C+AM&rft.au=Krause%2C+D&rft.au=Weidinger%2C+E&rft.au=Schwarz%2C+MJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-67"><span class="mw-cite-backlink"><b><a href="#cite_ref-67">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNaLeeLeeCho2014" class="citation journal cs1">Na KS, Lee KJ, Lee JS, Cho YS, Jung HY (January 2014). "Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: a meta-analysis". <i>Progress in Neuro-Psychopharmacology & Biological Psychiatry</i>. <b>48</b>: <span class="nowrap">79–</span>85. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pnpbp.2013.09.006">10.1016/j.pnpbp.2013.09.006</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24056287">24056287</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:35885429">35885429</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Progress+in+Neuro-Psychopharmacology+%26+Biological+Psychiatry&rft.atitle=Efficacy+of+adjunctive+celecoxib+treatment+for+patients+with+major+depressive+disorder%3A+a+meta-analysis&rft.volume=48&rft.pages=%3Cspan+class%3D%22nowrap%22%3E79-%3C%2Fspan%3E85&rft.date=2014-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A35885429%23id-name%3DS2CID&rft_id=info%3Apmid%2F24056287&rft_id=info%3Adoi%2F10.1016%2Fj.pnpbp.2013.09.006&rft.aulast=Na&rft.aufirst=KS&rft.au=Lee%2C+KJ&rft.au=Lee%2C+JS&rft.au=Cho%2C+YS&rft.au=Jung%2C+HY&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-68"><span class="mw-cite-backlink"><b><a href="#cite_ref-68">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRosenblatChaMansurMcIntyre2014" class="citation journal cs1">Rosenblat JD, Cha DS, Mansur RB, McIntyre RS (August 2014). "Inflamed moods: a review of the interactions between inflammation and mood disorders". <i>Progress in Neuro-Psychopharmacology & Biological Psychiatry</i>. <b>53</b>: <span class="nowrap">23–</span>34. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pnpbp.2014.01.013">10.1016/j.pnpbp.2014.01.013</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24468642">24468642</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:32289214">32289214</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Progress+in+Neuro-Psychopharmacology+%26+Biological+Psychiatry&rft.atitle=Inflamed+moods%3A+a+review+of+the+interactions+between+inflammation+and+mood+disorders&rft.volume=53&rft.pages=%3Cspan+class%3D%22nowrap%22%3E23-%3C%2Fspan%3E34&rft.date=2014-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A32289214%23id-name%3DS2CID&rft_id=info%3Apmid%2F24468642&rft_id=info%3Adoi%2F10.1016%2Fj.pnpbp.2014.01.013&rft.aulast=Rosenblat&rft.aufirst=JD&rft.au=Cha%2C+DS&rft.au=Mansur%2C+RB&rft.au=McIntyre%2C+RS&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-69"><span class="mw-cite-backlink"><b><a href="#cite_ref-69">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFondHamdaniKapczinskiBoukouaci2014" class="citation journal cs1">Fond G, Hamdani N, Kapczinski F, Boukouaci W, Drancourt N, Dargel A, et al. (March 2014). "Effectiveness and tolerance of anti-inflammatory drugs' add-on therapy in major mental disorders: a systematic qualitative review". <i>Acta Psychiatrica Scandinavica</i>. <b>129</b> (3): <span class="nowrap">163–</span>79. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Facps.12211">10.1111/acps.12211</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24215721">24215721</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:23482349">23482349</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Acta+Psychiatrica+Scandinavica&rft.atitle=Effectiveness+and+tolerance+of+anti-inflammatory+drugs%27+add-on+therapy+in+major+mental+disorders%3A+a+systematic+qualitative+review&rft.volume=129&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E163-%3C%2Fspan%3E79&rft.date=2014-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A23482349%23id-name%3DS2CID&rft_id=info%3Apmid%2F24215721&rft_id=info%3Adoi%2F10.1111%2Facps.12211&rft.aulast=Fond&rft.aufirst=G&rft.au=Hamdani%2C+N&rft.au=Kapczinski%2C+F&rft.au=Boukouaci%2C+W&rft.au=Drancourt%2C+N&rft.au=Dargel%2C+A&rft.au=Oliveira%2C+J&rft.au=Le+Guen%2C+E&rft.au=Marlinge%2C+E&rft.au=Tamouza%2C+R&rft.au=Leboyer%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-70"><span class="mw-cite-backlink"><b><a href="#cite_ref-70">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRialZellCohenGerner2012" class="citation journal cs1">Rial NS, Zell JA, Cohen AM, Gerner EW (August 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587976">"Clinical end points for developing pharmaceuticals to manage patients with a sporadic or genetic risk of colorectal cancer"</a>. <i><a href="/wiki/Expert_Review_of_Gastroenterology_%26_Hepatology" title="Expert Review of Gastroenterology & Hepatology">Expert Review of Gastroenterology & Hepatology</a></i>. <b>6</b> (4): <span class="nowrap">507–</span>17. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1586%2Fegh.12.23">10.1586/egh.12.23</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587976">3587976</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22928902">22928902</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Expert+Review+of+Gastroenterology+%26+Hepatology&rft.atitle=Clinical+end+points+for+developing+pharmaceuticals+to+manage+patients+with+a+sporadic+or+genetic+risk+of+colorectal+cancer&rft.volume=6&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E507-%3C%2Fspan%3E17&rft.date=2012-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3587976%23id-name%3DPMC&rft_id=info%3Apmid%2F22928902&rft_id=info%3Adoi%2F10.1586%2Fegh.12.23&rft.aulast=Rial&rft.aufirst=NS&rft.au=Zell%2C+JA&rft.au=Cohen%2C+AM&rft.au=Gerner%2C+EW&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3587976&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Bertagnolli-71"><span class="mw-cite-backlink"><b><a href="#cite_ref-Bertagnolli_71-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBertagnolliEagleZauberRedston2006" class="citation journal cs1">Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Solomon SD, Kim K, et al. (August 2006). <a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa061355">"Celecoxib for the prevention of sporadic colorectal adenomas"</a>. <i>The New England Journal of Medicine</i>. <b>355</b> (9): <span class="nowrap">873–</span>84. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa061355">10.1056/NEJMoa061355</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16943400">16943400</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Celecoxib+for+the+prevention+of+sporadic+colorectal+adenomas&rft.volume=355&rft.issue=9&rft.pages=%3Cspan+class%3D%22nowrap%22%3E873-%3C%2Fspan%3E84&rft.date=2006-08&rft_id=info%3Adoi%2F10.1056%2FNEJMoa061355&rft_id=info%3Apmid%2F16943400&rft.aulast=Bertagnolli&rft.aufirst=MM&rft.au=Eagle%2C+CJ&rft.au=Zauber%2C+AG&rft.au=Redston%2C+M&rft.au=Solomon%2C+SD&rft.au=Kim%2C+K&rft.au=Tang%2C+J&rft.au=Rosenstein%2C+RB&rft.au=Wittes%2C+J&rft.au=Corle%2C+D&rft.au=Hess%2C+TM&rft.au=Woloj%2C+GM&rft.au=Boisserie%2C+F&rft.au=Anderson%2C+WF&rft.au=Viner%2C+JL&rft.au=Bagheri%2C+D&rft.au=Burn%2C+J&rft.au=Chung%2C+DC&rft.au=Dewar%2C+T&rft.au=Foley%2C+TR&rft.au=Hoffman%2C+N&rft.au=Macrae%2C+F&rft.au=Pruitt%2C+RE&rft.au=Saltzman%2C+JR&rft.au=Salzberg%2C+B&rft.au=Sylwestrowicz%2C+T&rft.au=Gordon%2C+GB&rft.au=Hawk%2C+ET&rft_id=https%3A%2F%2Fdoi.org%2F10.1056%252FNEJMoa061355&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Baron-72"><span class="mw-cite-backlink"><b><a href="#cite_ref-Baron_72-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBaronColeSandlerHaile2003" class="citation journal cs1">Baron JA, Cole BF, Sandler RS, Haile RW, Ahnen D, Bresalier R, et al. (March 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa021735">"A randomized trial of aspirin to prevent colorectal adenomas"</a>. <i>The New England Journal of Medicine</i>. <b>348</b> (10): <span class="nowrap">891–</span>9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa021735">10.1056/NEJMoa021735</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12621133">12621133</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=A+randomized+trial+of+aspirin+to+prevent+colorectal+adenomas&rft.volume=348&rft.issue=10&rft.pages=%3Cspan+class%3D%22nowrap%22%3E891-%3C%2Fspan%3E9&rft.date=2003-03&rft_id=info%3Adoi%2F10.1056%2FNEJMoa021735&rft_id=info%3Apmid%2F12621133&rft.aulast=Baron&rft.aufirst=JA&rft.au=Cole%2C+BF&rft.au=Sandler%2C+RS&rft.au=Haile%2C+RW&rft.au=Ahnen%2C+D&rft.au=Bresalier%2C+R&rft.au=McKeown-Eyssen%2C+G&rft.au=Summers%2C+RW&rft.au=Rothstein%2C+R&rft.au=Burke%2C+CA&rft.au=Snover%2C+DC&rft.au=Church%2C+TR&rft.au=Allen%2C+JI&rft.au=Beach%2C+M&rft.au=Beck%2C+GJ&rft.au=Bond%2C+JH&rft.au=Byers%2C+T&rft.au=Greenberg%2C+ER&rft.au=Mandel%2C+JS&rft.au=Marcon%2C+N&rft.au=Mott%2C+LA&rft.au=Pearson%2C+L&rft.au=Saibil%2C+F&rft.au=van+Stolk%2C+RU&rft_id=https%3A%2F%2Fdoi.org%2F10.1056%252FNEJMoa021735&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Sandler-73"><span class="mw-cite-backlink"><b><a href="#cite_ref-Sandler_73-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSandlerHalabiBaronBudinger2003" class="citation journal cs1">Sandler RS, Halabi S, Baron JA, Budinger S, Paskett E, Keresztes R, et al. (March 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa021633">"A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer"</a>. <i>The New England Journal of Medicine</i>. <b>348</b> (10): <span class="nowrap">883–</span>90. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa021633">10.1056/NEJMoa021633</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12621132">12621132</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=A+randomized+trial+of+aspirin+to+prevent+colorectal+adenomas+in+patients+with+previous+colorectal+cancer&rft.volume=348&rft.issue=10&rft.pages=%3Cspan+class%3D%22nowrap%22%3E883-%3C%2Fspan%3E90&rft.date=2003-03&rft_id=info%3Adoi%2F10.1056%2FNEJMoa021633&rft_id=info%3Apmid%2F12621132&rft.aulast=Sandler&rft.aufirst=RS&rft.au=Halabi%2C+S&rft.au=Baron%2C+JA&rft.au=Budinger%2C+S&rft.au=Paskett%2C+E&rft.au=Keresztes%2C+R&rft.au=Petrelli%2C+N&rft.au=Pipas%2C+JM&rft.au=Karp%2C+DD&rft.au=Loprinzi%2C+CL&rft.au=Steinbach%2C+G&rft.au=Schilsky%2C+R&rft_id=https%3A%2F%2Fdoi.org%2F10.1056%252FNEJMoa021633&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Bosetti-74"><span class="mw-cite-backlink"><b><a href="#cite_ref-Bosetti_74-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBosettiTalaminiFranceschiNegri2003" class="citation journal cs1">Bosetti C, Talamini R, Franceschi S, Negri E, Garavello W, La Vecchia C (March 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376339">"Aspirin use and cancers of the upper aerodigestive tract"</a>. <i>British Journal of Cancer</i>. <b>88</b> (5): <span class="nowrap">672–</span>4. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.bjc.6600820">10.1038/sj.bjc.6600820</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376339">2376339</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12618872">12618872</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Aspirin+use+and+cancers+of+the+upper+aerodigestive+tract&rft.volume=88&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E672-%3C%2Fspan%3E4&rft.date=2003-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2376339%23id-name%3DPMC&rft_id=info%3Apmid%2F12618872&rft_id=info%3Adoi%2F10.1038%2Fsj.bjc.6600820&rft.aulast=Bosetti&rft.aufirst=C&rft.au=Talamini%2C+R&rft.au=Franceschi%2C+S&rft.au=Negri%2C+E&rft.au=Garavello%2C+W&rft.au=La+Vecchia%2C+C&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2376339&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Dannenberg-75"><span class="mw-cite-backlink"><b><a href="#cite_ref-Dannenberg_75-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDannenbergSubbaramaiah2003" class="citation journal cs1">Dannenberg AJ, Subbaramaiah K (December 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1535-6108%2803%2900310-6">"Targeting cyclooxygenase-2 in human neoplasia: rationale and promise"</a>. <i>Cancer Cell</i>. <b>4</b> (6): <span class="nowrap">431–</span>6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1535-6108%2803%2900310-6">10.1016/S1535-6108(03)00310-6</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14706335">14706335</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Cell&rft.atitle=Targeting+cyclooxygenase-2+in+human+neoplasia%3A+rationale+and+promise&rft.volume=4&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E431-%3C%2Fspan%3E6&rft.date=2003-12&rft_id=info%3Adoi%2F10.1016%2FS1535-6108%2803%2900310-6&rft_id=info%3Apmid%2F14706335&rft.aulast=Dannenberg&rft.aufirst=AJ&rft.au=Subbaramaiah%2C+K&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS1535-6108%252803%252900310-6&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-76"><span class="mw-cite-backlink"><b><a href="#cite_ref-76">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSchönthal2007" class="citation journal cs1">Schönthal AH (December 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360267">"Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy"</a>. <i>British Journal of Cancer</i>. <b>97</b> (11): <span class="nowrap">1465–</span>8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.bjc.6604049">10.1038/sj.bjc.6604049</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360267">2360267</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17955049">17955049</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Direct+non-cyclooxygenase-2+targets+of+celecoxib+and+their+potential+relevance+for+cancer+therapy&rft.volume=97&rft.issue=11&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1465-%3C%2Fspan%3E8&rft.date=2007-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2360267%23id-name%3DPMC&rft_id=info%3Apmid%2F17955049&rft_id=info%3Adoi%2F10.1038%2Fsj.bjc.6604049&rft.aulast=Sch%C3%B6nthal&rft.aufirst=AH&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2360267&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Chuang-77"><span class="mw-cite-backlink"><b><a href="#cite_ref-Chuang_77-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFChuangKardoshGaffneyPetasis2008" class="citation journal cs1">Chuang HC, Kardosh A, Gaffney KJ, Petasis NA, Schönthal AH (May 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396175">"COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro"</a>. <i>Molecular Cancer</i>. <b>7</b> (1): 38. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2F1476-4598-7-38">10.1186/1476-4598-7-38</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396175">2396175</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18485224">18485224</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Cancer&rft.atitle=COX-2+inhibition+is+neither+necessary+nor+sufficient+for+celecoxib+to+suppress+tumor+cell+proliferation+and+focus+formation+in+vitro&rft.volume=7&rft.issue=1&rft.pages=38&rft.date=2008-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2396175%23id-name%3DPMC&rft_id=info%3Apmid%2F18485224&rft_id=info%3Adoi%2F10.1186%2F1476-4598-7-38&rft.aulast=Chuang&rft.aufirst=HC&rft.au=Kardosh%2C+A&rft.au=Gaffney%2C+KJ&rft.au=Petasis%2C+NA&rft.au=Sch%C3%B6nthal%2C+AH&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2396175&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-78"><span class="mw-cite-backlink"><b><a href="#cite_ref-78">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMasferrerLeahyKokiZweifel2000" class="citation journal cs1">Masferrer JL, Leahy KM, Koki AT, Zweifel BS, Settle SL, Woerner BM, et al. (March 2000). <a rel="nofollow" class="external text" href="https://aacrjournals.org/cancerres/article/60/5/1306/507043/Antiangiogenic-and-Antitumor-Activities-of">"Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors"</a>. <i>Cancer Research</i>. <b>60</b> (5): <span class="nowrap">1306–</span>1311. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10728691">10728691</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Antiangiogenic+and+antitumor+activities+of+cyclooxygenase-2+inhibitors&rft.volume=60&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1306-%3C%2Fspan%3E1311&rft.date=2000-03&rft_id=info%3Apmid%2F10728691&rft.aulast=Masferrer&rft.aufirst=JL&rft.au=Leahy%2C+KM&rft.au=Koki%2C+AT&rft.au=Zweifel%2C+BS&rft.au=Settle%2C+SL&rft.au=Woerner%2C+BM&rft.au=Edwards%2C+DA&rft.au=Flickinger%2C+AG&rft.au=Moore%2C+RJ&rft.au=Seibert%2C+K&rft_id=https%3A%2F%2Faacrjournals.org%2Fcancerres%2Farticle%2F60%2F5%2F1306%2F507043%2FAntiangiogenic-and-Antitumor-Activities-of&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-zhu-79"><span class="mw-cite-backlink">^ <a href="#cite_ref-zhu_79-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-zhu_79-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhuSongLinYoung2002" class="citation journal cs1">Zhu J, Song X, Lin HP, Young DC, Yan S, Marquez VE, et al. (December 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjnci%2F94.23.1745">"Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents"</a>. <i>Journal of the National Cancer Institute</i>. <b>94</b> (23): <span class="nowrap">1745–</span>57. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjnci%2F94.23.1745">10.1093/jnci/94.23.1745</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12464646">12464646</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Using+cyclooxygenase-2+inhibitors+as+molecular+platforms+to+develop+a+new+class+of+apoptosis-inducing+agents&rft.volume=94&rft.issue=23&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1745-%3C%2Fspan%3E57&rft.date=2002-12&rft_id=info%3Adoi%2F10.1093%2Fjnci%2F94.23.1745&rft_id=info%3Apmid%2F12464646&rft.aulast=Zhu&rft.aufirst=J&rft.au=Song%2C+X&rft.au=Lin%2C+HP&rft.au=Young%2C+DC&rft.au=Yan%2C+S&rft.au=Marquez%2C+VE&rft.au=Chen%2C+CS&rft_id=https%3A%2F%2Fdoi.org%2F10.1093%252Fjnci%252F94.23.1745&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Schönthal-analogs-80"><span class="mw-cite-backlink"><b><a href="#cite_ref-Schönthal-analogs_80-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSchönthalChenHofmanLouie2008" class="citation journal cs1">Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA (February 2008). "Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs". <i>Expert Opinion on Investigational Drugs</i>. <b>17</b> (2): <span class="nowrap">197–</span>208. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1517%2F13543784.17.2.197">10.1517/13543784.17.2.197</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18230053">18230053</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:21093404">21093404</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Investigational+Drugs&rft.atitle=Celecoxib+analogs+that+lack+COX-2+inhibitory+function%3A+preclinical+development+of+novel+anticancer+drugs&rft.volume=17&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E197-%3C%2Fspan%3E208&rft.date=2008-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A21093404%23id-name%3DS2CID&rft_id=info%3Apmid%2F18230053&rft_id=info%3Adoi%2F10.1517%2F13543784.17.2.197&rft.aulast=Sch%C3%B6nthal&rft.aufirst=AH&rft.au=Chen%2C+TC&rft.au=Hofman%2C+FM&rft.au=Louie%2C+SG&rft.au=Petasis%2C+NA&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> <li id="cite_note-Schönthal-antitumor-81"><span class="mw-cite-backlink"><b><a href="#cite_ref-Schönthal-antitumor_81-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSchönthal2006" class="citation journal cs1">Schönthal AH (April 2006). <a rel="nofollow" class="external text" href="https://doi.org/10.3171%2Ffoc.2006.20.4.14">"Antitumor properties of dimethyl-celecoxib, a derivative of celecoxib that does not inhibit cyclooxygenase-2: implications for glioma therapy"</a>. <i>Neurosurgical Focus</i>. <b>20</b> (4): E21. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3171%2Ffoc.2006.20.4.14">10.3171/foc.2006.20.4.14</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16709027">16709027</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neurosurgical+Focus&rft.atitle=Antitumor+properties+of+dimethyl-celecoxib%2C+a+derivative+of+celecoxib+that+does+not+inhibit+cyclooxygenase-2%3A+implications+for+glioma+therapy&rft.volume=20&rft.issue=4&rft.pages=E21&rft.date=2006-04&rft_id=info%3Adoi%2F10.3171%2Ffoc.2006.20.4.14&rft_id=info%3Apmid%2F16709027&rft.aulast=Sch%C3%B6nthal&rft.aufirst=AH&rft_id=https%3A%2F%2Fdoi.org%2F10.3171%252Ffoc.2006.20.4.14&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=22" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDean2016" class="citation book cs1">Dean L (2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/books/NBK379478/">"Celecoxib Therapy and CYP2C9 Genotype"</a>. In Pratt VM, McLeod HL, Rubinstein WS, et al. (eds.). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/books/NBK61999/"><i>Medical Genetics Summaries</i></a>. <a href="/wiki/National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">National Center for Biotechnology Information</a> (NCBI). <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28520369">28520369</a>. Bookshelf ID: NBK379478.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Celecoxib+Therapy+and+CYP2C9+Genotype&rft.btitle=Medical+Genetics+Summaries&rft.pub=National+Center+for+Biotechnology+Information+%28NCBI%29&rft.date=2016&rft_id=info%3Apmid%2F28520369&rft.aulast=Dean&rft.aufirst=L&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fbooks%2FNBK379478%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhangDingSong2006" class="citation journal cs1">Zhang J, Ding EL, Song Y (October 2006). "Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials". <i>JAMA</i>. <b>296</b> (13): <span class="nowrap">1619–</span>32. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Fjama.296.13.jrv60015">10.1001/jama.296.13.jrv60015</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16968832">16968832</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Adverse+effects+of+cyclooxygenase+2+inhibitors+on+renal+and+arrhythmia+events%3A+meta-analysis+of+randomized+trials&rft.volume=296&rft.issue=13&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1619-%3C%2Fspan%3E32&rft.date=2006-10&rft_id=info%3Adoi%2F10.1001%2Fjama.296.13.jrv60015&rft_id=info%3Apmid%2F16968832&rft.aulast=Zhang&rft.aufirst=J&rft.au=Ding%2C+EL&rft.au=Song%2C+Y&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Celecoxib&action=edit&section=23" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/cox-2-selective-includes-bextra-celebrex-and-vioxx-and-non-selective-non-steroidal-anti-inflammatory">"COX-2 Selective (includes Bextra, Celebrex, and Vioxx) and Non-Selective Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>. 15 July 2005.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=COX-2+Selective+%28includes+Bextra%2C+Celebrex%2C+and+Vioxx%29+and+Non-Selective+Non-Steroidal+Anti-Inflammatory+Drugs+%28NSAIDs%29&rft.date=2005-07-15&rft_id=https%3A%2F%2Fwww.fda.gov%2Fdrugs%2Fpostmarket-drug-safety-information-patients-and-providers%2Fcox-2-selective-includes-bextra-celebrex-and-vioxx-and-non-selective-non-steroidal-anti-inflammatory&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/drugs/drug-safety-and-availability/cder-statement-fda-approves-labeling-supplement-celebrex-celecoxib">"FDA Approves Labeling Supplement for Celebrex (celecoxib)"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>. 28 June 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=FDA+Approves+Labeling+Supplement+for+Celebrex+%28celecoxib%29&rft.date=2018-06-28&rft_id=https%3A%2F%2Fwww.fda.gov%2Fdrugs%2Fdrug-safety-and-availability%2Fcder-statement-fda-approves-labeling-supplement-celebrex-celecoxib&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACelecoxib" class="Z3988"></span></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output 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href="/wiki/Template:Chemotherapeutic_agents" title="Template:Chemotherapeutic agents"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Chemotherapeutic_agents" class="mw-redirect" title="Template talk:Chemotherapeutic agents"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Chemotherapeutic_agents" title="Special:EditPage/Template:Chemotherapeutic agents"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Intracellular_chemotherapeutic_agents_/_antineoplastic_agents_(L01)604" style="font-size:114%;margin:0 4em">Intracellular <a href="/wiki/Chemotherapy" title="Chemotherapy">chemotherapeutic agents</a> / <a href="/wiki/Antineoplastic" class="mw-redirect" title="Antineoplastic">antineoplastic agents</a> (<a href="/wiki/ATC_code_L01" title="ATC code L01">L01</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Spindle_poison" title="Spindle poison">SPs</a>/<a href="/wiki/Mitotic_inhibitor" title="Mitotic inhibitor">MIs</a><br />(<a href="/wiki/M_phase" class="mw-redirect" title="M phase">M phase</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Block <a href="/wiki/Microtubule" title="Microtubule">microtubule</a> assembly</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Vinca_alkaloid" title="Vinca alkaloid">Vinca alkaloids</a></i> (<a href="/wiki/Vinblastine" title="Vinblastine">Vinblastine</a><sup>#</sup></li> <li><a href="/wiki/Vincristine" title="Vincristine">Vincristine</a><sup>#</sup></li> <li><a href="/wiki/Vindesine" title="Vindesine">Vindesine</a></li> <li><a href="/wiki/Vinflunine" title="Vinflunine">Vinflunine</a><sup>§</sup></li> <li><a href="/wiki/Vinorelbine" title="Vinorelbine">Vinorelbine</a><sup>#</sup>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Block microtubule disassembly</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Taxane" title="Taxane">Taxanes</a></i> (<a href="/wiki/Cabazitaxel" title="Cabazitaxel">Cabazitaxel</a></li> <li><a href="/wiki/Docetaxel" title="Docetaxel">Docetaxel</a><sup>#</sup></li> <li><a href="/wiki/Larotaxel" title="Larotaxel">Larotaxel</a></li> <li><a href="/wiki/Ortataxel" title="Ortataxel">Ortataxel</a><sup>†</sup></li> <li><a href="/wiki/Paclitaxel" title="Paclitaxel">Paclitaxel</a><sup>#</sup></li> <li><a href="/wiki/Tesetaxel" title="Tesetaxel">Tesetaxel</a>)</li> <li><i><a href="/wiki/Epothilone" title="Epothilone">Epothilones</a></i> (<a href="/wiki/Ixabepilone" title="Ixabepilone">Ixabepilone</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/DNA_replication" title="DNA replication">DNA replication</a><br />inhibitor</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">DNA precursors/<br /><a href="/wiki/Antimetabolite" title="Antimetabolite">antimetabolites</a><br />(<a href="/wiki/S_phase" title="S phase">S phase</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Antifolate" title="Antifolate">Folic acid</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Dihydrofolate_reductase_inhibitor" title="Dihydrofolate reductase inhibitor">Dihydrofolate reductase inhibitor</a></i> (<a href="/wiki/Aminopterin" title="Aminopterin">Aminopterin</a></li> <li><a href="/wiki/Methotrexate" title="Methotrexate">Methotrexate</a><sup>#</sup></li> <li><a href="/wiki/Pemetrexed" title="Pemetrexed">Pemetrexed</a></li> <li><a href="/wiki/Pralatrexate" title="Pralatrexate">Pralatrexate</a>)</li> <li><i><a href="/wiki/Thymidylate_synthase_inhibitor" title="Thymidylate synthase inhibitor">Thymidylate synthase inhibitor</a></i> (<a href="/wiki/Pemetrexed" title="Pemetrexed">Pemetrexed</a></li> <li><a href="/wiki/Raltitrexed" title="Raltitrexed">Raltitrexed</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Purine_analogue" title="Purine analogue">Purine</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Adenosine_deaminase_inhibitor" class="mw-redirect" title="Adenosine deaminase inhibitor">Adenosine deaminase inhibitor</a></i> (<a href="/wiki/Pentostatin" title="Pentostatin">Pentostatin</a>)</li></ul> <ul><li><i><a href="/wiki/Halogenation" title="Halogenation">Halogenated</a>/<a href="/wiki/Ribonucleotide_reductase_inhibitor" title="Ribonucleotide reductase inhibitor">ribonucleotide reductase inhibitors</a></i> (<a href="/wiki/Cladribine" title="Cladribine">Cladribine</a></li> <li><a href="/wiki/Clofarabine" title="Clofarabine">Clofarabine</a></li> <li><a href="/wiki/Fludarabine" title="Fludarabine">Fludarabine</a>)</li> <li><a href="/wiki/Nelarabine" title="Nelarabine">Nelarabine</a></li> <li><a href="/wiki/Rabacfosadine" title="Rabacfosadine">Rabacfosadine</a></li> <li><i><a href="/wiki/Thiopurine" title="Thiopurine">Thiopurine</a></i> (<a href="/wiki/Mercaptopurine" title="Mercaptopurine">Mercaptopurine</a><sup>#</sup></li> <li><a href="/wiki/Tioguanine" title="Tioguanine">Tioguanine</a><sup>#</sup>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pyrimidine_analogue" title="Pyrimidine analogue">Pyrimidine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Thymidylate_synthase_inhibitor" title="Thymidylate synthase inhibitor">Thymidylate synthase inhibitor</a></i> (<a href="/wiki/Capecitabine" title="Capecitabine">Capecitabine</a><sup>#</sup></li> <li><a href="/wiki/Carmofur" title="Carmofur">Carmofur</a></li> <li><a href="/wiki/Doxifluridine" title="Doxifluridine">Doxifluridine</a></li> <li><a href="/wiki/Floxuridine" title="Floxuridine">Floxuridine</a></li> <li><a href="/wiki/Fluorouracil" title="Fluorouracil">Fluorouracil</a><sup>#</sup></li> <li><a href="/wiki/Tegafur" title="Tegafur">Tegafur</a> (<a href="/wiki/Tegafur/gimeracil/oteracil" title="Tegafur/gimeracil/oteracil">+gimeracil/oteracil</a>))</li></ul> <ul><li><i><a href="/wiki/DNA_polymerase_inhibitor" class="mw-redirect" title="DNA polymerase inhibitor">DNA polymerase inhibitor</a></i> (<a href="/wiki/Cytarabine" title="Cytarabine">Cytarabine</a><sup>#</sup> <a href="/wiki/Daunorubicin/cytarabine" title="Daunorubicin/cytarabine">+daunorubicin</a>)</li></ul> <ul><li><i><a href="/wiki/Ribonucleotide_reductase_inhibitor" title="Ribonucleotide reductase inhibitor">Ribonucleotide reductase inhibitor</a></i> (<a href="/wiki/Gemcitabine" title="Gemcitabine">Gemcitabine</a><sup>#</sup>)</li></ul> <ul><li><i><a href="/wiki/Hypomethylating_agent" title="Hypomethylating agent">Hypomethylating agent</a></i> (<a href="/wiki/Azacitidine" title="Azacitidine">Azacitidine</a></li> <li><a href="/wiki/Decitabine" title="Decitabine">Decitabine</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Deoxyribonucleotide" title="Deoxyribonucleotide">Deoxyribonucleotide</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Ribonucleotide_reductase_inhibitor" title="Ribonucleotide reductase inhibitor">Ribonucleotide reductase inhibitor</a></i> (<a href="/wiki/Hydroxycarbamide" title="Hydroxycarbamide">Hydroxycarbamide</a><sup>#</sup>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Topoisomerase_inhibitor" title="Topoisomerase inhibitor">Topoisomerase inhibitors</a><br />(<a href="/wiki/S_phase" title="S phase">S phase</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Type_I_topoisomerase#Inhibition" title="Type I topoisomerase">I</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Camptotheca" title="Camptotheca">Camptotheca</a></i> (<a href="/wiki/Belotecan" title="Belotecan">Belotecan</a></li> <li><a href="/wiki/Camptothecin" title="Camptothecin">Camptothecin</a></li> <li><a href="/w/index.php?title=Cositecan&action=edit&redlink=1" class="new" title="Cositecan (page does not exist)">Cositecan</a><sup>†</sup></li> <li><a href="/wiki/Etirinotecan_pegol" title="Etirinotecan pegol">Etirinotecan pegol</a><sup>†</sup></li> <li><a href="/wiki/Exatecan" title="Exatecan">Exatecan</a></li> <li><a href="/w/index.php?title=Gimatecan&action=edit&redlink=1" class="new" title="Gimatecan (page does not exist)">Gimatecan</a></li> <li><a href="/wiki/Irinotecan" title="Irinotecan">Irinotecan</a><sup>#</sup></li> <li><a href="/wiki/Lurtotecan" title="Lurtotecan">Lurtotecan</a><sup>‡</sup></li> <li><a href="/wiki/Rubitecan" title="Rubitecan">Rubitecan</a><sup>‡</sup></li> <li><a href="/w/index.php?title=Silatecan&action=edit&redlink=1" class="new" title="Silatecan (page does not exist)">Silatecan</a><sup>§</sup></li> <li><a href="/wiki/Topotecan" title="Topotecan">Topotecan</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Type_II_topoisomerase#Inhibition" title="Type II topoisomerase">II</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Podophyllum_peltatum" title="Podophyllum peltatum">Podophyllum</a></i> (<a href="/wiki/Etoposide" title="Etoposide">Etoposide</a><sup>#</sup></li> <li><a href="/wiki/Teniposide" title="Teniposide">Teniposide</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Type_II_topoisomerase#Inhibition" title="Type II topoisomerase">II</a>+<a href="/wiki/Intercalation_(biochemistry)" title="Intercalation (biochemistry)">Intercalation</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Anthracycline" title="Anthracycline">Anthracyclines</a></i> (<a href="/wiki/Aclarubicin" title="Aclarubicin">Aclarubicin</a></li> <li><a href="/wiki/Amrubicin" title="Amrubicin">Amrubicin</a><sup>†</sup></li> <li><a href="/wiki/Daunorubicin" title="Daunorubicin">Daunorubicin</a><sup>#</sup> (<a href="/wiki/Daunorubicin/cytarabine" title="Daunorubicin/cytarabine">+cytarabine</a>)</li> <li><a href="/wiki/Doxorubicin" title="Doxorubicin">Doxorubicin</a><sup>#</sup></li> <li><a href="/wiki/Epirubicin" title="Epirubicin">Epirubicin</a></li> <li><a href="/wiki/Idarubicin" title="Idarubicin">Idarubicin</a></li> <li><a href="/wiki/Pirarubicin" title="Pirarubicin">Pirarubicin</a></li> <li><a href="/wiki/Valrubicin" title="Valrubicin">Valrubicin</a></li> <li><a href="/wiki/Zorubicin" title="Zorubicin">Zorubicin</a>)</li> <li><i><a href="/wiki/Anthraquinone" title="Anthraquinone">Anthracenediones</a></i> (<a href="/wiki/Losoxantrone" title="Losoxantrone">Losoxantrone</a></li> <li><a href="/wiki/Mitoxantrone" title="Mitoxantrone">Mitoxantrone</a></li> <li><a href="/wiki/Pixantrone" title="Pixantrone">Pixantrone</a>)</li> <li><a href="/wiki/Amsacrine" title="Amsacrine">Amsacrine</a></li> <li><a href="/wiki/Bisantrene" title="Bisantrene">Bisantrene</a></li> <li><a href="/wiki/Crisnatol" title="Crisnatol">Crisnatol</a></li> <li><a href="/wiki/Menogaril" title="Menogaril">Menogaril</a><sup>§</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Crosslinking_of_DNA" title="Crosslinking of DNA">Crosslinking of DNA</a><br />(<a href="/wiki/Cell-cycle_nonspecific_antineoplastic_agents" title="Cell-cycle nonspecific antineoplastic agents">CCNS</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Alkylating_antineoplastic_agent" title="Alkylating antineoplastic agent">Alkylating</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Nitrogen_mustard" title="Nitrogen mustard">Nitrogen mustards</a>:</i> <a href="/wiki/Bendamustine" title="Bendamustine">Bendamustine</a><sup>#</sup></li> <li><a href="/wiki/Chlormethine" title="Chlormethine">Chlormethine</a></li> <li><a href="/wiki/Cyclophosphamide" title="Cyclophosphamide">Cyclophosphamide</a><sup>#</sup> (<a href="/wiki/Ifosfamide" title="Ifosfamide">Ifosfamide</a><sup>#</sup></li> <li><a href="/wiki/Trofosfamide" title="Trofosfamide">Trofosfamide</a>)</li> <li><a href="/wiki/Chlorambucil" title="Chlorambucil">Chlorambucil</a><sup>#</sup></li> <li><a href="/wiki/Melphalan" title="Melphalan">Melphalan</a> (<a href="/wiki/Melphalan_flufenamide" title="Melphalan flufenamide">Melphalan flufenamide</a>)</li> <li><a href="/wiki/Prednimustine" title="Prednimustine">Prednimustine</a></li> <li><a href="/wiki/Uramustine" title="Uramustine">Uramustine</a></li></ul> <ul><li><i><a href="/wiki/Nitrosourea" title="Nitrosourea">Nitrosoureas</a>:</i> <a href="/wiki/Carmustine" title="Carmustine">Carmustine</a></li> <li><a href="/wiki/Fotemustine" title="Fotemustine">Fotemustine</a></li> <li><a href="/wiki/Lomustine" title="Lomustine">Lomustine</a> (<a href="/wiki/Semustine" title="Semustine">Semustine</a>)</li> <li><a href="/wiki/Nimustine" title="Nimustine">Nimustine</a></li> <li><a href="/wiki/Ranimustine" title="Ranimustine">Ranimustine</a></li> <li><a href="/wiki/Streptozotocin" title="Streptozotocin">Streptozocin</a></li></ul> <ul><li><i><a href="/wiki/Alkyl_sulfonate" title="Alkyl sulfonate">Alkyl sulfonates</a>:</i> <a href="/wiki/Busulfan" title="Busulfan">Busulfan</a> (<a href="/wiki/Mannosulfan" title="Mannosulfan">Mannosulfan</a></li> <li><a href="/wiki/Treosulfan" title="Treosulfan">Treosulfan</a>)</li></ul> <ul><li><i><a href="/wiki/Aziridine" title="Aziridine">Aziridines</a>:</i> <a href="/wiki/Carboquone" title="Carboquone">Carboquone</a></li> <li><a href="/wiki/Thiotepa" title="Thiotepa">Thiotepa</a></li> <li><a href="/wiki/Triaziquone" title="Triaziquone">Triaziquone</a></li> <li><a href="/wiki/Triethylenemelamine" title="Triethylenemelamine">Triethylenemelamine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Platinum-based_antineoplastic" title="Platinum-based antineoplastic">Platinum-based</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carboplatin" title="Carboplatin">Carboplatin</a><sup>#</sup></li> <li><a href="/wiki/Cisplatin" title="Cisplatin">Cisplatin</a><sup>#</sup></li> <li><a href="/wiki/Dicycloplatin" title="Dicycloplatin">Dicycloplatin</a></li> <li><a href="/wiki/Nedaplatin" title="Nedaplatin">Nedaplatin</a></li> <li><a href="/wiki/Oxaliplatin" title="Oxaliplatin">Oxaliplatin</a><sup>#</sup></li> <li><a href="/wiki/Satraplatin" title="Satraplatin">Satraplatin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Alkylating_antineoplastic_agent#Nonclassical" title="Alkylating antineoplastic agent">Nonclassical</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Altretamine" title="Altretamine">Altretamine</a></li> <li><i><a href="/wiki/Hydrazine" title="Hydrazine">Hydrazines</a></i> (<a href="/wiki/Procarbazine" title="Procarbazine">Procarbazine</a><sup>#</sup>)</li> <li><a href="/wiki/Etoglucid" title="Etoglucid">Etoglucid</a></li> <li><a href="/wiki/Mitobronitol" title="Mitobronitol">Mitobronitol</a></li> <li><a href="/wiki/Pipobroman" title="Pipobroman">Pipobroman</a></li> <li><i><a href="/wiki/Triazene" title="Triazene">Triazenes</a></i> (<a href="/wiki/Dacarbazine" title="Dacarbazine">Dacarbazine</a><sup>#</sup></li> <li><a href="/wiki/Mitozolomide" title="Mitozolomide">Mitozolomide</a><sup>§</sup></li> <li><a href="/wiki/Temozolomide" title="Temozolomide">Temozolomide</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Intercalation_(biochemistry)" title="Intercalation (biochemistry)">Intercalation</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Streptomyces" title="Streptomyces">Streptomyces</a> (<a href="/wiki/Dactinomycin" title="Dactinomycin">Dactinomycin</a><sup>#</sup></li> <li><a href="/wiki/Bleomycin" title="Bleomycin">Bleomycin</a><sup>#</sup></li> <li><a href="/wiki/Mitomycins" title="Mitomycins">Mitomycins</a></li> <li><a href="/wiki/Plicamycin" title="Plicamycin">Plicamycin</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Photosensitizer" title="Photosensitizer">Photosensitizers</a>/<a href="/wiki/Photodynamic_therapy" title="Photodynamic therapy">PDT</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aminolevulinic_acid" title="Aminolevulinic acid">Aminolevulinic acid</a></li> <li><a href="/wiki/Efaproxiral" title="Efaproxiral">Efaproxiral</a></li> <li><a href="/wiki/Methyl_aminolevulinate" title="Methyl aminolevulinate">Methyl aminolevulinate</a></li> <li><a href="/wiki/Padeliporfin" title="Padeliporfin">Padeliporfin</a></li> <li><i><a href="/wiki/Porphyrin" title="Porphyrin">Porphyrin derivatives</a></i> (<a href="/wiki/Porfimer_sodium" title="Porfimer sodium">Porfimer sodium</a></li> <li><a href="/wiki/Talaporfin" title="Talaporfin">Talaporfin</a></li> <li><a href="/wiki/Temoporfin" title="Temoporfin">Temoporfin</a></li> <li><a href="/wiki/Verteporfin" title="Verteporfin">Verteporfin</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Farnesyltransferase_inhibitor" title="Farnesyltransferase inhibitor">FI</a></i> (<a href="/wiki/Tipifarnib" title="Tipifarnib">Tipifarnib</a><sup>§</sup>)</li> <li><i><a href="/wiki/Cyclin-dependent_kinase" title="Cyclin-dependent kinase">CDK</a> <a href="/wiki/Protein_kinase_inhibitor" title="Protein kinase inhibitor">inhibitors</a></i> (<a href="/wiki/Abemaciclib" title="Abemaciclib">Abemaciclib</a></li> <li><a href="/wiki/Alvocidib" title="Alvocidib">Alvocidib</a><sup>†</sup></li> <li><a href="/wiki/Palbociclib" title="Palbociclib">Palbociclib</a></li> <li><a href="/wiki/Ribociclib" title="Ribociclib">Ribociclib</a></li> <li><a href="/wiki/Seliciclib" title="Seliciclib">Seliciclib</a><sup>†</sup>)</li> <li><i><a href="/wiki/Proteasome_inhibitor" title="Proteasome inhibitor">PrI</a></i> <ul><li><a href="/wiki/Bortezomib" title="Bortezomib">Bortezomib</a></li> <li><a href="/wiki/Carfilzomib" title="Carfilzomib">Carfilzomib</a></li> <li><a href="/wiki/Oprozomib" title="Oprozomib">Oprozomib</a></li> <li><a href="/wiki/Ixazomib" title="Ixazomib">Ixazomib</a></li></ul></li> <li><i><a href="/wiki/Phosphodiesterase_inhibitor" title="Phosphodiesterase inhibitor">PhI</a></i> (<a href="/wiki/Anagrelide" title="Anagrelide">Anagrelide</a>)</li> <li><i><a href="/wiki/IMP_dehydrogenase" class="mw-redirect" title="IMP dehydrogenase">IMPDI</a></i> (<a href="/wiki/Tiazofurin" title="Tiazofurin">Tiazofurin</a><sup>§</sup>)</li> <li><i><a href="/wiki/Lipoxygenase_inhibitor" class="mw-redirect" title="Lipoxygenase inhibitor">LI</a></i> (<a href="/wiki/Masoprocol" title="Masoprocol">Masoprocol</a>)</li> <li><i><a href="/wiki/PARP_inhibitor" title="PARP inhibitor">PARP inhibitor</a></i> (<a href="/wiki/Fuzuloparib" title="Fuzuloparib">Fuzuloparib</a></li> <li><a href="/wiki/Niraparib" title="Niraparib">Niraparib</a> <a href="/wiki/Niraparib/abiraterone_acetate" title="Niraparib/abiraterone acetate">+abiraterone acetate</a></li> <li><a href="/wiki/Olaparib" title="Olaparib">Olaparib</a></li> <li><a href="/wiki/Rucaparib" title="Rucaparib">Rucaparib</a>)</li> <li><i><a href="/wiki/Histone_deacetylase_inhibitor" title="Histone deacetylase inhibitor">HDAC</a></i> (<a href="/wiki/Belinostat" title="Belinostat">Belinostat</a></li> <li><a href="/wiki/Entinostat" title="Entinostat">Entinostat</a></li> <li><a href="/wiki/Panobinostat" title="Panobinostat">Panobinostat</a></li> <li><a href="/wiki/Romidepsin" title="Romidepsin">Romidepsin</a></li> <li><a href="/wiki/Vorinostat" title="Vorinostat">Vorinostat</a>)</li> <li><i><a href="/wiki/Phosphoinositide_3-kinase_inhibitor" title="Phosphoinositide 3-kinase inhibitor">PIKI</a> (Pi3K)</i> (<a href="/wiki/Alpelisib" title="Alpelisib">Alpelisib</a></li> <li><a href="/wiki/Copanlisib" title="Copanlisib">Copanlisib</a><sup>‡</sup></li> <li><a href="/wiki/Duvelisib" title="Duvelisib">Duvelisib</a></li> <li><a href="/wiki/Idelalisib" title="Idelalisib">Idelalisib</a></li> <li><a href="/wiki/Inavolisib" title="Inavolisib">Inavolisib</a></li> <li><a href="/wiki/Umbralisib" title="Umbralisib">Umbralisib</a><sup>‡</sup>)</li> <li><i><a href="/wiki/Isocitrate_dehydrogenase" title="Isocitrate dehydrogenase">IDH</a></i> (<a href="/wiki/Enasidenib" title="Enasidenib">Enasidenib</a></li> <li><a href="/wiki/Ivosidenib" title="Ivosidenib">Ivosidenib</a></li> <li><a href="/wiki/Olutasidenib" title="Olutasidenib">Olutasidenib</a></li> <li><a href="/wiki/Vorasidenib" title="Vorasidenib">Vorasidenib</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_antagonist" title="Receptor antagonist">Receptor antagonists</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Endothelin_receptor_antagonist" title="Endothelin receptor antagonist">ERA</a></i> (<a href="/wiki/Atrasentan" title="Atrasentan">Atrasentan</a>)</li> <li><i><a href="/wiki/Retinoid_X_receptor" title="Retinoid X receptor">Retinoid X receptor</a></i> (<a href="/wiki/Bexarotene" title="Bexarotene">Bexarotene</a>)</li> <li><i><a href="/wiki/Sex_steroid" class="mw-redirect" title="Sex steroid">Sex steroid</a></i> (<a href="/wiki/Testolactone" title="Testolactone">Testolactone</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other/ungrouped</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adagrasib" title="Adagrasib">Adagrasib</a></li> <li><a href="/wiki/Aflibercept" title="Aflibercept">Aflibercept</a></li> <li><a href="/wiki/Arsenic_trioxide" title="Arsenic trioxide">Arsenic trioxide</a></li> <li><i><a href="/wiki/Asparagine" title="Asparagine">Asparagine depleters</a></i> (<a href="/wiki/Asparaginase" title="Asparaginase">Asparaginase</a><sup>#</sup>/<a href="/wiki/Pegaspargase" title="Pegaspargase">Pegaspargase</a>)</li> <li><a href="/wiki/Axicabtagene_ciloleucel" title="Axicabtagene ciloleucel">Axicabtagene ciloleucel</a></li> <li><a href="/wiki/Belzutifan" title="Belzutifan">Belzutifan</a></li> <li><a href="/wiki/Bexarotene" title="Bexarotene">Bexarotene</a></li> <li><a href="/wiki/Brexucabtagene_autoleucel" title="Brexucabtagene autoleucel">Brexucabtagene autoleucel</a></li> <li><a class="mw-selflink selflink">Celecoxib</a></li> <li><a href="/wiki/Ciltacabtagene_autoleucel" title="Ciltacabtagene autoleucel">Ciltacabtagene autoleucel</a></li> <li><a href="/wiki/Demecolcine" title="Demecolcine">Demecolcine</a></li> <li><a href="/wiki/Denileukin_diftitox" title="Denileukin diftitox">Denileukin diftitox</a></li> <li><a href="/wiki/Eflornithine" title="Eflornithine">Eflornithine</a></li> <li><a href="/wiki/Elesclomol" title="Elesclomol">Elesclomol</a><sup>§</sup></li> <li><a href="/wiki/Elsamitrucin" title="Elsamitrucin">Elsamitrucin</a></li> <li><a href="/wiki/Epacadostat" title="Epacadostat">Epacadostat</a></li> <li><a href="/wiki/Eribulin" title="Eribulin">Eribulin</a></li> <li><a href="/wiki/Estramustine_phosphate" title="Estramustine phosphate">Estramustine</a></li> <li><a href="/wiki/Glasdegib" title="Glasdegib">Glasdegib</a></li> <li><a href="/wiki/Idecabtagene_vicleucel" title="Idecabtagene vicleucel">Idecabtagene vicleucel</a></li> <li><a href="/wiki/Imetelstat" title="Imetelstat">Imetelstat</a></li> <li><a href="/wiki/Lifileucel" title="Lifileucel">Lifileucel</a></li> <li><a href="/wiki/Lisocabtagene_maraleucel" title="Lisocabtagene maraleucel">Lisocabtagene maraleucel</a></li> <li><a href="/wiki/Lonidamine" title="Lonidamine">Lonidamine</a></li> <li><a href="/wiki/Lucanthone" title="Lucanthone">Lucanthone</a></li> <li><a href="/wiki/Lurbinectedin" title="Lurbinectedin">Lurbinectedin</a></li> <li><a href="/wiki/Mitoguazone" title="Mitoguazone">Mitoguazone</a></li> <li><a href="/wiki/Mitotane" title="Mitotane">Mitotane</a></li> <li><a href="/wiki/Nadofaragene_firadenovec" title="Nadofaragene firadenovec">Nadofaragene firadenovec</a></li> <li><a href="/wiki/Navitoclax" title="Navitoclax">Navitoclax</a></li> <li><a href="/wiki/Obecabtagene_autoleucel" title="Obecabtagene autoleucel">Obecabtagene autoleucel</a></li> <li><a href="/wiki/Oblimersen" title="Oblimersen">Oblimersen</a><sup>†</sup></li> <li><a href="/wiki/Omacetaxine_mepesuccinate" title="Omacetaxine mepesuccinate">Omacetaxine mepesuccinate</a></li> <li><a href="/wiki/Plitidepsin" title="Plitidepsin">Plitidepsin</a></li> <li><a href="/wiki/Tabelecleucel" title="Tabelecleucel">Tabelecleucel</a></li> <li><i><a href="/wiki/Retinoid" title="Retinoid">Retinoids</a></i> (<a href="/wiki/Alitretinoin" title="Alitretinoin">Alitretinoin</a></li> <li><a href="/wiki/Tretinoin" title="Tretinoin">Tretinoin</a><sup>#</sup>)</li> <li><a href="/wiki/Selinexor" title="Selinexor">Selinexor</a></li> <li><a href="/w/index.php?title=Sitimagene_ceradenovec&action=edit&redlink=1" class="new" title="Sitimagene ceradenovec (page does not exist)">Sitimagene ceradenovec</a></li> <li><a href="/wiki/Sotorasib" title="Sotorasib">Sotorasib</a></li> <li><a href="/wiki/Tagraxofusp" title="Tagraxofusp">Tagraxofusp</a></li> <li><a href="/wiki/Talimogene_laherparepvec" title="Talimogene laherparepvec">Talimogene laherparepvec</a></li> <li><a href="/wiki/Tazemetostat" title="Tazemetostat">Tazemetostat</a></li> <li><a href="/wiki/Tebentafusp" title="Tebentafusp">Tebentafusp</a></li> <li><a href="/wiki/Tiazofurine" class="mw-redirect" title="Tiazofurine">Tiazofurine</a></li> <li><a href="/wiki/Tigilanol_tiglate" title="Tigilanol tiglate">Tigilanol tiglate</a></li> <li><a href="/wiki/Tisagenlecleucel" title="Tisagenlecleucel">Tisagenlecleucel</a></li> <li><a href="/wiki/Trabectedin" title="Trabectedin">Trabectedin</a></li> <li><a href="/wiki/Veliparib" title="Veliparib">Veliparib</a></li> <li><a href="/wiki/Venetoclax" title="Venetoclax">Venetoclax</a></li> <li><a href="/w/index.php?title=Verdinexor&action=edit&redlink=1" class="new" title="Verdinexor (page does not exist)">Verdinexor</a></li> <li><a href="/wiki/Vosaroxin" title="Vosaroxin">Vosaroxin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="padding: 0px;"><div><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li><sup>‡</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li><sup>†</sup><a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li><sup>§</sup>Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Non-steroidal_anti-inflammatory_drugs_(NSAIDs)_(primarily_M01A_and_M02A,_also_N02BA)808" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Anti-inflammatory_products" title="Template:Anti-inflammatory products"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Anti-inflammatory_products" title="Template talk:Anti-inflammatory products"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Anti-inflammatory_products" title="Special:EditPage/Template:Anti-inflammatory products"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Non-steroidal_anti-inflammatory_drugs_(NSAIDs)_(primarily_M01A_and_M02A,_also_N02BA)808" style="font-size:114%;margin:0 4em"><a href="/wiki/Non-steroidal_anti-inflammatory_drug" class="mw-redirect" title="Non-steroidal anti-inflammatory drug">Non-steroidal anti-inflammatory drugs</a> (NSAIDs) (primarily <a href="/wiki/ATC_code_M01#M01A" title="ATC code M01">M01A</a> and <a href="/wiki/ATC_code_M02#M02A" title="ATC code M02">M02A</a>, also <a href="/wiki/ATC_code_N02#N02BA" title="ATC code N02">N02BA</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pyrazolone" title="Pyrazolone">pyrazolones</a> /<br /><a href="/wiki/Pyrazolidine" title="Pyrazolidine">pyrazolidines</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aminophenazone" title="Aminophenazone">Aminophenazone</a></li> <li><a href="/wiki/Ampyrone" title="Ampyrone">Ampyrone</a></li> <li><a href="/wiki/Azapropazone" title="Azapropazone">Azapropazone</a></li> <li><a href="/wiki/Clofezone" title="Clofezone">Clofezone</a></li> <li><a href="/wiki/Difenamizole" title="Difenamizole">Difenamizole</a></li> <li><a href="/wiki/Famprofazone" title="Famprofazone">Famprofazone</a></li> <li><a href="/wiki/Feprazone" title="Feprazone">Feprazone</a></li> <li><a href="/wiki/Kebuzone" title="Kebuzone">Kebuzone</a></li> <li><a href="/wiki/Metamizole" title="Metamizole">Metamizole</a></li> <li><a href="/wiki/Mofebutazone" title="Mofebutazone">Mofebutazone</a></li> <li><a href="/wiki/Morazone" title="Morazone">Morazone</a></li> <li><a href="/wiki/Nifenazone" title="Nifenazone">Nifenazone</a></li> <li><a href="/wiki/Oxyphenbutazone" title="Oxyphenbutazone">Oxyphenbutazone</a></li> <li><a href="/wiki/Phenazone" title="Phenazone">Phenazone</a></li> <li><u><a href="/wiki/Phenylbutazone" title="Phenylbutazone">Phenylbutazone</a></u></li> <li><a href="/wiki/Propyphenazone" title="Propyphenazone">Propyphenazone</a></li> <li><a href="/wiki/Sulfinpyrazone" title="Sulfinpyrazone">Sulfinpyrazone</a></li> <li><a href="/wiki/Suxibuzone" title="Suxibuzone">Suxibuzone</a><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Salicylic_acid" title="Salicylic acid">salicylates</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><u><a href="/wiki/Aspirin" title="Aspirin">Aspirin (acetylsalicylic acid)</a></u><sup>#</sup></li> <li><a href="/wiki/Aloxiprin" title="Aloxiprin">Aloxiprin</a></li> <li><a href="/wiki/Benorilate" title="Benorilate">Benorylate</a></li> <li><a href="/wiki/Carbasalate_calcium" title="Carbasalate calcium">Carbasalate calcium</a></li> <li><a href="/wiki/Diflunisal" title="Diflunisal">Diflunisal</a></li> <li><a href="/wiki/Dipyrocetyl" title="Dipyrocetyl">Dipyrocetyl</a></li> <li><a href="/wiki/Ethenzamide" title="Ethenzamide">Ethenzamide</a></li> <li><a href="/wiki/Guacetisal" title="Guacetisal">Guacetisal</a></li> <li><a href="/wiki/Magnesium_salicylate" title="Magnesium salicylate">Magnesium salicylate</a></li> <li><a href="/wiki/Methyl_salicylate" title="Methyl salicylate">Methyl salicylate</a></li> <li><a href="/wiki/Salsalate" title="Salsalate">Salsalate</a></li> <li><a href="/wiki/Salicin" title="Salicin">Salicin</a></li> <li><a href="/wiki/Salicylamide" title="Salicylamide">Salicylamide</a></li> <li><a href="/wiki/Salicylic_acid" title="Salicylic acid">Salicylic acid (salicylate)</a></li> <li><a href="/wiki/Sodium_salicylate" title="Sodium salicylate">Sodium salicylate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Acetic_acid" title="Acetic acid">acetic acid</a> derivatives<br />and related substances</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aceclofenac" title="Aceclofenac">Aceclofenac</a></li> <li><a href="/wiki/Acemetacin" title="Acemetacin">Acemetacin</a></li> <li><a href="/wiki/Alclofenac" title="Alclofenac">Alclofenac</a></li> <li><a href="/wiki/Amfenac" title="Amfenac">Amfenac</a></li> <li><a href="/wiki/Bendazac" title="Bendazac">Bendazac</a></li> <li><a href="/wiki/Bromfenac" title="Bromfenac">Bromfenac</a></li> <li><a href="/wiki/Bufexamac" title="Bufexamac">Bufexamac</a></li> <li><a href="/wiki/Bumadizone" title="Bumadizone">Bumadizone</a></li> <li><u><a href="/wiki/Diclofenac" title="Diclofenac">Diclofenac</a></u></li> <li><a href="/wiki/Difenpiramide" title="Difenpiramide">Difenpiramide</a></li> <li><a href="/wiki/Etodolac" title="Etodolac">Etodolac</a></li> <li><a href="/wiki/Felbinac" title="Felbinac">Felbinac</a></li> <li><a href="/wiki/Fenclozic_acid" title="Fenclozic acid">Fenclozic acid</a></li> <li><a href="/wiki/Fentiazac" title="Fentiazac">Fentiazac</a></li> <li><a href="/wiki/Indometacin" title="Indometacin">Indometacin</a></li> <li><a href="/wiki/Indometacin_farnesil" title="Indometacin farnesil">Indometacin farnesil</a></li> <li><a href="/w/index.php?title=Isoxepac&action=edit&redlink=1" class="new" title="Isoxepac (page does not exist)">Isoxepac</a></li> <li><a href="/wiki/Ketorolac" title="Ketorolac">Ketorolac</a></li> <li><a href="/wiki/Lonazolac" title="Lonazolac">Lonazolac</a></li> <li><a href="/wiki/Mofezolac" title="Mofezolac">Mofezolac</a></li> <li><a href="/wiki/Oxametacin" title="Oxametacin">Oxametacin</a></li> <li><a href="/w/index.php?title=Prodolic_acid&action=edit&redlink=1" class="new" title="Prodolic acid (page does not exist)">Prodolic acid</a></li> <li><a href="/wiki/Proglumetacin" title="Proglumetacin">Proglumetacin</a></li> <li><a href="/wiki/Sulindac" title="Sulindac">Sulindac</a></li> <li><a href="/w/index.php?title=Tiopinac&action=edit&redlink=1" class="new" title="Tiopinac (page does not exist)">Tiopinac</a></li> <li><a href="/wiki/Tolmetin" title="Tolmetin">Tolmetin</a></li> <li><a href="/wiki/Zomepirac" title="Zomepirac">Zomepirac</a><sup>†</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Oxicam" title="Oxicam">oxicams</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ampiroxicam" title="Ampiroxicam">Ampiroxicam</a></li> <li><a href="/wiki/Droxicam" title="Droxicam">Droxicam</a></li> <li><a href="/wiki/Isoxicam" title="Isoxicam">Isoxicam</a></li> <li><a href="/wiki/Lornoxicam" title="Lornoxicam">Lornoxicam</a></li> <li><a href="/wiki/Meloxicam" title="Meloxicam">Meloxicam</a></li> <li><u><a href="/wiki/Piroxicam" title="Piroxicam">Piroxicam</a></u></li> <li><a href="/w/index.php?title=Pivoxicam&action=edit&redlink=1" class="new" title="Pivoxicam (page does not exist)">Pivoxicam</a></li> <li><a href="/wiki/Tenoxicam" title="Tenoxicam">Tenoxicam</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Propionic_acid" title="Propionic acid">propionic acid</a><br />derivatives (<a href="/wiki/Profens" class="mw-redirect" title="Profens">profens</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alminoprofen" title="Alminoprofen">Alminoprofen</a></li> <li><a href="/wiki/Benoxaprofen" title="Benoxaprofen">Benoxaprofen</a><sup>†</sup></li> <li><a href="/wiki/Carprofen" title="Carprofen">Carprofen</a><sup>‡</sup></li> <li><a href="/wiki/Dexibuprofen" title="Dexibuprofen">Dexibuprofen</a></li> <li><a href="/wiki/Dexketoprofen" title="Dexketoprofen">Dexketoprofen</a></li> <li><a href="/wiki/Fenbufen" title="Fenbufen">Fenbufen</a></li> <li><a href="/wiki/Fenoprofen" title="Fenoprofen">Fenoprofen</a></li> <li><a href="/wiki/Flunoxaprofen" title="Flunoxaprofen">Flunoxaprofen</a></li> <li><a href="/wiki/Flurbiprofen" title="Flurbiprofen">Flurbiprofen</a></li> <li><u><a href="/wiki/Ibuprofen" title="Ibuprofen">Ibuprofen</a></u><sup>#</sup></li> <li><a href="/wiki/Ibuproxam" title="Ibuproxam">Ibuproxam</a></li> <li><a href="/wiki/Indoprofen" title="Indoprofen">Indoprofen</a><sup>†</sup></li> <li><a href="/wiki/Ketoprofen" title="Ketoprofen">Ketoprofen</a></li> <li><a href="/wiki/Loxoprofen" title="Loxoprofen">Loxoprofen</a></li> <li><a href="/wiki/Miroprofen" title="Miroprofen">Miroprofen</a></li> <li><u><a href="/wiki/Naproxen" title="Naproxen">Naproxen</a></u></li> <li><a href="/wiki/Oxaprozin" title="Oxaprozin">Oxaprozin</a></li> <li><a href="/wiki/Pelubiprofen" title="Pelubiprofen">Pelubiprofen</a></li> <li><a href="/wiki/Piketoprofen" title="Piketoprofen">Piketoprofen</a></li> <li><a href="/wiki/Pirprofen" title="Pirprofen">Pirprofen</a></li> <li><a href="/wiki/Suprofen" title="Suprofen">Suprofen</a></li> <li><a href="/wiki/Tarenflurbil" title="Tarenflurbil">Tarenflurbil</a></li> <li><a href="/wiki/Tepoxalin" title="Tepoxalin">Tepoxalin</a><sup>‡</sup></li> <li><a href="/wiki/Tiaprofenic_acid" title="Tiaprofenic acid">Tiaprofenic acid</a></li> <li><a href="/wiki/Vedaprofen" title="Vedaprofen">Vedaprofen</a><sup>‡</sup></li> <li><a href="/wiki/Zaltoprofen" title="Zaltoprofen">Zaltoprofen</a></li> <li><i><a href="/wiki/COX-inhibiting_nitric_oxide_donator" title="COX-inhibiting nitric oxide donator">COX-inhibiting nitric oxide donator</a></i>: <a href="/wiki/Naproxcinod" title="Naproxcinod">Naproxcinod</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><i>n</i>-arylanthranilic<br />acids (<a href="/wiki/Fenamate" class="mw-redirect" title="Fenamate">fenamates</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Azapropazone" title="Azapropazone">Azapropazone</a></li> <li><a href="/wiki/Clonixin" title="Clonixin">Clonixin</a></li> <li><a href="/wiki/Etofenamate" title="Etofenamate">Etofenamate</a></li> <li><a href="/wiki/Floctafenine" title="Floctafenine">Floctafenine</a></li> <li><a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Flunixin" title="Flunixin">Flunixin</a></li> <li><a href="/w/index.php?title=Flutiazin&action=edit&redlink=1" class="new" title="Flutiazin (page does not exist)">Flutiazin</a></li> <li><a href="/wiki/Glafenine" title="Glafenine">Glafenine</a><sup>†</sup></li> <li><a href="/wiki/Meclofenamic_acid" title="Meclofenamic acid">Meclofenamic acid</a></li> <li><u><a href="/wiki/Mefenamic_acid" title="Mefenamic acid">Mefenamic acid</a></u></li> <li><a href="/wiki/Morniflumate" title="Morniflumate">Morniflumate</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li> <li><a href="/wiki/Tolfenamic_acid" title="Tolfenamic acid">Tolfenamic acid</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/COX-2_inhibitor" class="mw-redirect" title="COX-2 inhibitor">COX-2 inhibitors</a><br />(coxibs)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Apricoxib" title="Apricoxib">Apricoxib</a></li> <li><u><a class="mw-selflink selflink">Celecoxib</a></u> (<a href="/wiki/Celecoxib/tramadol" title="Celecoxib/tramadol">+tramadol</a>)</li> <li><a href="/wiki/Cimicoxib" title="Cimicoxib">Cimicoxib</a><sup>‡</sup></li> <li><a href="/wiki/Deracoxib" title="Deracoxib">Deracoxib</a><sup>‡</sup></li> <li><a href="/wiki/Etoricoxib" title="Etoricoxib">Etoricoxib</a></li> <li><a href="/wiki/Firocoxib" title="Firocoxib">Firocoxib</a><sup>‡</sup></li> <li><a href="/wiki/Lumiracoxib" title="Lumiracoxib">Lumiracoxib</a><sup>†</sup></li> <li><a href="/wiki/Mavacoxib" title="Mavacoxib">Mavacoxib</a><sup>‡</sup></li> <li><a href="/wiki/Parecoxib" title="Parecoxib">Parecoxib</a></li> <li><a href="/wiki/Robenacoxib" title="Robenacoxib">Robenacoxib</a><sup>‡</sup></li> <li><a href="/wiki/Rofecoxib" title="Rofecoxib">Rofecoxib</a><sup>†</sup></li> <li><a href="/wiki/Valdecoxib" title="Valdecoxib">Valdecoxib</a><sup>†</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aminopropionitrile" title="Aminopropionitrile">Aminopropionitrile</a></li> <li><a href="/wiki/Benzydamine" title="Benzydamine">Benzydamine</a></li> <li><a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">Chondroitin sulfate</a></li> <li><a href="/wiki/Diacerein" title="Diacerein">Diacerein</a></li> <li><a href="/wiki/Fluproquazone" title="Fluproquazone">Fluproquazone</a></li> <li><a href="/wiki/Glucosamine" title="Glucosamine">Glucosamine</a></li> <li><a href="/wiki/Glycosaminoglycan" title="Glycosaminoglycan">Glycosaminoglycan</a></li> <li><a href="/wiki/Hyperforin" title="Hyperforin">Hyperforin</a></li> <li><a href="/wiki/Nabumetone" title="Nabumetone">Nabumetone</a></li> <li><a href="/wiki/Nimesulide" title="Nimesulide">Nimesulide</a></li> <li><a href="/wiki/Oxaceprol" title="Oxaceprol">Oxaceprol</a></li> <li><a href="/wiki/Proquazone" title="Proquazone">Proquazone</a></li> <li><a href="/wiki/Superoxide_dismutase" title="Superoxide dismutase">Superoxide dismutase / orgotein</a></li> <li><a href="/wiki/Tenidap" title="Tenidap">Tenidap</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">NSAID<br />combinations</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ibuprofen/famotidine" title="Ibuprofen/famotidine">Ibuprofen/famotidine</a></li> <li><a href="/wiki/Hydrocodone/ibuprofen" title="Hydrocodone/ibuprofen">Ibuprofen/hydrocodone</a></li> <li><a href="/wiki/Oxycodone/ibuprofen" title="Oxycodone/ibuprofen">Ibuprofen/oxycodone</a></li> <li><a href="/wiki/Ibuprofen/paracetamol" title="Ibuprofen/paracetamol">Ibuprofen/paracetamol</a></li> <li><a href="/wiki/Bupivacaine/meloxicam" title="Bupivacaine/meloxicam">Meloxicam/bupivacaine</a></li> <li><a href="/wiki/Meloxicam/rizatriptan" title="Meloxicam/rizatriptan">Meloxicam/rizatriptan</a></li> <li><a href="/wiki/Naproxen/diphenhydramine" title="Naproxen/diphenhydramine">Naproxen/diphenhydramine</a></li> <li><a href="/wiki/Naproxen/esomeprazole" title="Naproxen/esomeprazole">Naproxen/esomeprazole</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">Key: <u>underline</u> indicates initially developed first-in-class compound of specific group; <sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-Essential Medicines</a>; <sup>†</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">withdrawn drugs</a>; <sup>‡</sup><a href="/wiki/Veterinary_medicine" title="Veterinary medicine">veterinary use</a>.</div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li><span class="noviewer" typeof="mw:File"><span title="Category"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/16px-Symbol_category_class.svg.png" decoding="async" width="16" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/23px-Symbol_category_class.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/31px-Symbol_category_class.svg.png 2x" data-file-width="180" data-file-height="185" /></span></span> <a href="/wiki/Category:Anti-inflammatory_and_antirheumatic_products" title="Category:Anti-inflammatory and antirheumatic products">category</a></li> <li><span class="noviewer" typeof="mw:File"><span title="Commons page"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/12px-Commons-logo.svg.png" decoding="async" width="12" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/24px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></span></span> <a href="https://commons.wikimedia.org/wiki/Category:Anti-inflammatory_drugs" class="extiw" title="commons:Category:Anti-inflammatory drugs">commons</a></li> <li><span class="noviewer" typeof="mw:File"><a href="/wiki/File:Symbol_portal_class.svg" class="mw-file-description" title="Portal"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/e/e2/Symbol_portal_class.svg/16px-Symbol_portal_class.svg.png" decoding="async" width="16" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/e/e2/Symbol_portal_class.svg/23px-Symbol_portal_class.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/e/e2/Symbol_portal_class.svg/31px-Symbol_portal_class.svg.png 2x" data-file-width="180" data-file-height="185" /></a></span> <a href="/wiki/Portal:Medicine" title="Portal:Medicine">portal</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"></div><div role="navigation" class="navbox" aria-labelledby="Analgesics_(N02A,_N02B)251" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Analgesics" title="Template:Analgesics"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Analgesics" title="Template talk:Analgesics"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Analgesics" title="Special:EditPage/Template:Analgesics"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Analgesics_(N02A,_N02B)251" style="font-size:114%;margin:0 4em"><a href="/wiki/Analgesic" title="Analgesic">Analgesics</a> (<a href="/wiki/ATC_code_N02#N02A" title="ATC code N02">N02A</a>, <a href="/wiki/ATC_code_N02#N02B" title="ATC code N02">N02B</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Opioid" title="Opioid">Opioids</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Opiate" title="Opiate">Opiates</a>/<a href="/wiki/Opium" title="Opium">opium</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Codeine" title="Codeine">Codeine</a><sup>#</sup> <ul><li><a href="/wiki/Codeine/aspirin" class="mw-redirect" title="Codeine/aspirin">+aspirin</a></li> <li><a href="/wiki/Codeine/paracetamol" title="Codeine/paracetamol">+paracetamol</a></li></ul></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a><sup>#</sup> (<a href="/wiki/Morphine/naltrexone" title="Morphine/naltrexone">+naltrexone</a>)</li> <li><a href="/wiki/Opium" title="Opium">Opium</a></li> <li><a href="/wiki/Laudanum" title="Laudanum">Laudanum</a></li> <li><a href="/wiki/Paregoric" title="Paregoric">Paregoric</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Semisynthetic</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acetyldihydrocodeine" title="Acetyldihydrocodeine">Acetyldihydrocodeine</a></li> <li><a href="/wiki/Benzylmorphine" title="Benzylmorphine">Benzylmorphine</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a><span class="nowrap"> </span>(<a href="/wiki/Buprenorphine/naloxone" title="Buprenorphine/naloxone">+naloxone</a>)</li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/Desomorphine" title="Desomorphine">Desomorphine</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Dihydrocodeine" title="Dihydrocodeine">Dihydrocodeine</a><span class="nowrap"> </span>(<a href="/wiki/Co-dydramol" title="Co-dydramol">+paracetamol</a>)</li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Ethylmorphine" title="Ethylmorphine">Ethylmorphine</a></li> <li><a href="/wiki/Hydrocodone" title="Hydrocodone">Hydrocodone</a><span class="nowrap"> </span>(<a href="/wiki/Hydrocodone/paracetamol" title="Hydrocodone/paracetamol">+paracetamol</a>, <a href="/wiki/Hydrocodone/ibuprofen" title="Hydrocodone/ibuprofen">+ibuprofen</a>, <a href="/wiki/Hydrocodone/aspirin" title="Hydrocodone/aspirin">+aspirin</a>)</li> <li><a href="/wiki/Hydromorphinol" title="Hydromorphinol">Hydromorphinol</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/wiki/Metopon" title="Metopon">Metopon</a></li> <li><a href="/wiki/Nalbuphine" title="Nalbuphine">Nalbuphine</a></li> <li><a href="/wiki/Nicocodeine" title="Nicocodeine">Nicocodeine</a></li> <li><a href="/wiki/Nicodicodine" title="Nicodicodine">Nicodicodine</a></li> <li><a href="/wiki/Nicomorphine" title="Nicomorphine">Nicomorphine</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a><span class="nowrap"> </span>(<a href="/wiki/Oxycodone/paracetamol" title="Oxycodone/paracetamol">+paracetamol</a>, <a href="/wiki/Oxycodone/aspirin" title="Oxycodone/aspirin">+aspirin</a>, <a href="/wiki/Oxycodone/ibuprofen" title="Oxycodone/ibuprofen">+ibuprofen</a>, <a href="/wiki/Oxycodone/naloxone" title="Oxycodone/naloxone">+naloxone</a>, <a href="/w/index.php?title=Oxycodone/naltrexone&action=edit&redlink=1" class="new" title="Oxycodone/naltrexone (page does not exist)">+naltrexone</a>)</li> <li><a href="/wiki/Oxymorphone" title="Oxymorphone">Oxymorphone</a></li> <li><a href="/wiki/Papaveretum" title="Papaveretum">Papaveretum</a></li> <li><a href="/wiki/Thebacon" title="Thebacon">Thebacon</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Synthetic</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alfentanil" title="Alfentanil">Alfentanil</a></li> <li><a href="/wiki/Prodine" title="Prodine">Alphaprodine</a></li> <li><a href="/wiki/Anileridine" title="Anileridine">Anileridine</a></li> <li><a href="/wiki/Bezitramide" title="Bezitramide">Bezitramide</a></li> <li><a href="/wiki/Carfentanil" title="Carfentanil">Carfentanil</a></li> <li><a href="/wiki/Dextromoramide" title="Dextromoramide">Dextromoramide</a></li> <li><a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">Dextropropoxyphene</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/wiki/Dimenoxadol" title="Dimenoxadol">Dimenoxadol</a></li> <li><a href="/wiki/Dipipanone" title="Dipipanone">Dipipanone</a></li> <li><a href="/wiki/Ethoheptazine" title="Ethoheptazine">Ethoheptazine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a><sup>#</sup> (<a href="/wiki/Fentanyl/fluanisone" title="Fentanyl/fluanisone">+fluanisone</a>)</li> <li><a href="/wiki/Ketobemidone" title="Ketobemidone">Ketobemidone</a></li> <li><a href="/wiki/Lofentanil" title="Lofentanil">Lofentanil</a></li> <li><a href="/wiki/Meptazinol" title="Meptazinol">Meptazinol</a></li> <li><a href="/wiki/Methadone" title="Methadone">Methadone</a><sup>#</sup></li> <li><a href="/wiki/NFEPP" title="NFEPP">NFEPP</a></li> <li><a href="/wiki/Norpipanone" title="Norpipanone">Norpipanone</a></li> <li><a href="/wiki/Oliceridine" title="Oliceridine">Oliceridine</a></li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phenadoxone" title="Phenadoxone">Phenadoxone</a></li> <li><a href="/wiki/Phenazocine" title="Phenazocine">Phenazocine</a></li> <li><a href="/wiki/Phenoperidine" title="Phenoperidine">Phenoperidine</a></li> <li><a href="/wiki/Piminodine" title="Piminodine">Piminodine</a></li> <li><a href="/wiki/Piritramide" title="Piritramide">Piritramide</a></li> <li><a href="/wiki/Proheptazine" title="Proheptazine">Proheptazine</a></li> <li><a href="/wiki/Propiram" title="Propiram">Propiram</a></li> <li><a href="/wiki/Remifentanil" title="Remifentanil">Remifentanil</a></li> <li><a href="/wiki/Sufentanil" title="Sufentanil">Sufentanil</a></li> <li><a href="/wiki/Tapentadol" title="Tapentadol">Tapentadol</a></li> <li><a href="/wiki/Tilidine" title="Tilidine">Tilidine</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a><span class="nowrap"> </span>(<a href="/wiki/Celecoxib/tramadol" title="Celecoxib/tramadol">+celecoxib</a>, <a href="/wiki/Tramadol/paracetamol" title="Tramadol/paracetamol">+paracetamol</a>)</li> <li><a href="/wiki/Viminol" title="Viminol">Viminol</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Paracetamol" title="Paracetamol">Paracetamol</a>-type</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acetanilide" title="Acetanilide">Acetanilide</a><sup>‡</sup></li> <li><a href="/wiki/Bucetin" title="Bucetin">Bucetin</a><sup>‡</sup></li> <li><a href="/w/index.php?title=Butacetin&action=edit&redlink=1" class="new" title="Butacetin (page does not exist)">Butacetin</a><sup>‡</sup></li> <li><a href="/wiki/Paracetamol" title="Paracetamol">Paracetamol (acetaminophen)</a><sup>#</sup> <ul><li><a href="/wiki/Aspirin/paracetamol/caffeine" title="Aspirin/paracetamol/caffeine">+aspirin/caffeine</a></li> <li><a href="/wiki/Codeine/paracetamol" title="Codeine/paracetamol">+codeine</a></li> <li><a href="/wiki/Hydrocodone/paracetamol" title="Hydrocodone/paracetamol">+hydrocodone</a></li> <li><a href="/wiki/Ibuprofen/paracetamol" title="Ibuprofen/paracetamol">+ibuprofen</a></li> <li><a href="/wiki/Paracetamol/metoclopramide" title="Paracetamol/metoclopramide">+metoclopramide</a></li> <li><a href="/wiki/Oxycodone/paracetamol" title="Oxycodone/paracetamol">+oxycodone</a></li> <li><a href="/wiki/Propyphenazone/paracetamol/caffeine" title="Propyphenazone/paracetamol/caffeine">+propyphenazone/caffeine</a></li> <li><a href="/wiki/Tramadol/paracetamol" title="Tramadol/paracetamol">+tramadol</a></li></ul></li> <li><a href="/w/index.php?title=Parapropamol&action=edit&redlink=1" class="new" title="Parapropamol (page does not exist)">Parapropamol</a><sup>‡</sup></li> <li><a href="/wiki/Phenacetin" title="Phenacetin">Phenacetin</a><sup>‡</sup></li> <li><a href="/wiki/Propacetamol" title="Propacetamol">Propacetamol</a><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nonsteroidal_anti-inflammatory_drug" title="Nonsteroidal anti-inflammatory drug">NSAIDs</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Propionates</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Benoxaprofen" title="Benoxaprofen">Benoxaprofen</a> <sup>‡</sup></li> <li><a href="/wiki/Fenoprofen" title="Fenoprofen">Fenoprofen</a></li> <li><a href="/wiki/Flurbiprofen" title="Flurbiprofen">Flurbiprofen</a></li> <li><a href="/wiki/Ibuprofen" title="Ibuprofen">Ibuprofen</a><sup>#</sup><span class="nowrap"> </span>(<a href="/wiki/Dexibuprofen" title="Dexibuprofen">Dexibuprofen</a>)<span class="nowrap"> </span>(<a href="/wiki/Ibuprofen/paracetamol" title="Ibuprofen/paracetamol">+paracetamol</a>)</li> <li><a href="/wiki/Ketoprofen" title="Ketoprofen">Ketoprofen</a><span class="nowrap"> </span>(<a href="/wiki/Dexketoprofen" title="Dexketoprofen">Dexketoprofen</a>)</li> <li><a href="/wiki/Loxoprofen" title="Loxoprofen">Loxoprofen</a></li> <li><a href="/wiki/Naproxen" title="Naproxen">Naproxen</a></li> <li><a href="/wiki/Oxaprozin" title="Oxaprozin">Oxaprozin</a></li> <li><a href="/wiki/Suprofen" title="Suprofen">Suprofen</a></li> <li><a href="/wiki/Tiaprofenic_acid" title="Tiaprofenic acid">Tiaprofenic acid</a></li> <li><a href="/wiki/Zaltoprofen" title="Zaltoprofen">Zaltoprofen</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Oxicams</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Isoxicam" title="Isoxicam">Isoxicam</a></li> <li><a href="/wiki/Lornoxicam" title="Lornoxicam">Lornoxicam</a></li> <li><a href="/wiki/Meloxicam" title="Meloxicam">Meloxicam</a></li> <li><a href="/wiki/Piroxicam" title="Piroxicam">Piroxicam</a></li> <li><a href="/wiki/Tenoxicam" title="Tenoxicam">Tenoxicam</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Acetates</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acemetacin" title="Acemetacin">Acemetacin</a></li> <li><a href="/wiki/Bromfenac" title="Bromfenac">Bromfenac</a></li> <li><a href="/wiki/Diclofenac" title="Diclofenac">Diclofenac</a></li> <li><a href="/wiki/Etodolac" title="Etodolac">Etodolac</a></li> <li><a href="/wiki/Indometacin" title="Indometacin">Indometacin</a><span class="nowrap"> </span>(<a href="/wiki/Indometacin_farnesil" title="Indometacin farnesil">Indometacin farnesil</a>)</li> <li><a href="/wiki/Ketorolac" title="Ketorolac">Ketorolac</a></li> <li><a href="/wiki/Sulindac" title="Sulindac">Sulindac</a></li> <li><a href="/wiki/Tolmetin" title="Tolmetin">Tolmetin</a></li> <li><a href="/wiki/Zomepirac" title="Zomepirac">Zomepirac</a> <sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/COX-2_inhibitor" class="mw-redirect" title="COX-2 inhibitor">COX-2 inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Celecoxib</a><span class="nowrap"> </span>(<a href="/wiki/Celecoxib/tramadol" title="Celecoxib/tramadol">+tramadol</a>)</li> <li><a href="/wiki/Etoricoxib" title="Etoricoxib">Etoricoxib</a></li> <li><a href="/wiki/Lumiracoxib" title="Lumiracoxib">Lumiracoxib</a> <sup>‡</sup></li> <li><a href="/wiki/Parecoxib" title="Parecoxib">Parecoxib</a></li> <li><a href="/wiki/Rofecoxib" title="Rofecoxib">Rofecoxib</a> <sup>‡</sup></li> <li><a href="/wiki/Valdecoxib" title="Valdecoxib">Valdecoxib</a> <sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fenamic_acid" title="Fenamic acid">Fenamates</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Meclofenamic_acid" title="Meclofenamic acid">Meclofenamic acid</a></li> <li><a href="/wiki/Mefenamic_acid" title="Mefenamic acid">Mefenamic acid</a></li> <li><a href="/wiki/Tolfenamic_acid" title="Tolfenamic acid">Tolfenamic acid</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Salicylic_acid" title="Salicylic acid">Salicylates</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aspirin" title="Aspirin">Aspirin (acetylsalicylic acid)</a><sup>#</sup> (<a href="/wiki/Aspirin/paracetamol/caffeine" title="Aspirin/paracetamol/caffeine">+paracetamol/caffeine</a>)</li> <li><a href="/wiki/Aloxiprin" title="Aloxiprin">Aloxiprin</a></li> <li><a href="/wiki/Benorilate" title="Benorilate">Benorylate</a></li> <li><a href="/wiki/Carbasalate_calcium" title="Carbasalate calcium">Carbasalate calcium</a></li> <li><a href="/wiki/Choline_salicylate" class="mw-redirect" title="Choline salicylate">Choline salicylate</a></li> <li><a href="/wiki/Diflunisal" title="Diflunisal">Diflunisal</a></li> <li><a href="/wiki/Dipyrocetyl" title="Dipyrocetyl">Dipyrocetyl</a></li> <li><a href="/wiki/Ethenzamide" title="Ethenzamide">Ethenzamide</a></li> <li><a href="/wiki/Guacetisal" title="Guacetisal">Guacetisal</a></li> <li><a href="/wiki/Imidazole_salicylate" title="Imidazole salicylate">Imidazole salicylate</a></li> <li><a href="/wiki/Magnesium_salicylate" title="Magnesium salicylate">Magnesium salicylate</a></li> <li><a href="/wiki/Morpholine_salicylate" title="Morpholine salicylate">Morpholine salicylate</a></li> <li><a href="/wiki/Potassium_salicylate" title="Potassium salicylate">Potassium salicylate</a></li> <li><a href="/wiki/Salicin" title="Salicin">Salicin</a></li> <li><a href="/wiki/Salicylamide" title="Salicylamide">Salicylamide</a></li> <li><a href="/wiki/Salsalate" title="Salsalate">Salsalate</a></li> <li><a href="/wiki/Sodium_salicylate" title="Sodium salicylate">Sodium salicylate</a></li> <li><a href="/wiki/Wintergreen" title="Wintergreen">Wintergreen</a><span class="nowrap"> </span>(<a href="/wiki/Methyl_salicylate" title="Methyl salicylate">methyl salicylate</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pyrazolone" title="Pyrazolone">Pyrazolones</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aminophenazone" title="Aminophenazone">Aminophenazone</a><sup>‡</sup></li> <li><a href="/wiki/Ampyrone" title="Ampyrone">Ampyrone</a></li> <li><a href="/wiki/Metamizole" title="Metamizole">Metamizole (dipyrone)</a></li> <li><a href="/wiki/Nifenazone" title="Nifenazone">Nifenazone</a></li> <li><a href="/wiki/Phenazone" title="Phenazone">Phenazone</a></li> <li><a href="/wiki/Propyphenazone" title="Propyphenazone">Propyphenazone</a><span class="nowrap"> </span>(<a href="/wiki/Propyphenazone/paracetamol/caffeine" title="Propyphenazone/paracetamol/caffeine">+paracetamol/caffeine</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Benzydamine" title="Benzydamine">Benzydamine</a></li> <li><a href="/wiki/Floctafenine" title="Floctafenine">Floctafenine</a></li> <li><a href="/wiki/Glafenine" title="Glafenine">Glafenine</a></li> <li><a href="/wiki/Nabumetone" title="Nabumetone">Nabumetone</a></li> <li><a href="/wiki/Nimesulide" title="Nimesulide">Nimesulide</a></li> <li><a href="/wiki/Proquazone" title="Proquazone">Proquazone</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cannabinoid" title="Cannabinoid">Cannabinoids</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cannabidiol" title="Cannabidiol">Cannabidiol</a></li> <li><a href="/wiki/Cannabis_(drug)" title="Cannabis (drug)">Cannabis</a></li> <li><a href="/wiki/Nabilone" title="Nabilone">Nabilone</a></li> <li><a href="/wiki/Nabiximols" title="Nabiximols">Nabiximols</a></li> <li><a href="/wiki/Tetrahydrocannabinol" title="Tetrahydrocannabinol">Tetrahydrocannabinol (dronabinol)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Channel_modulator" title="Channel modulator">Ion channel<br />modulators</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Calcium_channel_blocker" title="Calcium channel blocker">Calcium blockers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Alcohol (ethanol)</a></li> <li><a href="/wiki/Gabapentin" title="Gabapentin">Gabapentin</a></li> <li><a href="/wiki/Gabapentin_enacarbil" title="Gabapentin enacarbil">Gabapentin enacarbil</a></li> <li><a href="/wiki/Leconotide" title="Leconotide">Leconotide</a></li> <li><a href="/wiki/Mirogabalin" title="Mirogabalin">Mirogabalin</a></li> <li><a href="/wiki/Pregabalin" title="Pregabalin">Pregabalin</a></li> <li><a href="/wiki/Ziconotide" title="Ziconotide">Ziconotide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Sodium_channel_blocker" title="Sodium channel blocker">Sodium blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carbamazepine" title="Carbamazepine">Carbamazepine</a></li> <li><a href="/wiki/Lacosamide" title="Lacosamide">Lacosamide</a></li> <li><a href="/wiki/Local_anesthetic" title="Local anesthetic">Local anesthetics</a> (e.g., <a href="/wiki/Cocaine" title="Cocaine">cocaine</a>, <a href="/wiki/Lidocaine" title="Lidocaine">lidocaine</a>)</li> <li><a href="/wiki/Mexiletine" title="Mexiletine">Mexiletine</a></li> <li><a href="/wiki/Nefopam" title="Nefopam">Nefopam</a></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="/wiki/Amitriptyline" title="Amitriptyline">amitriptyline</a><sup>#</sup>)</li></ul> <ul><li><i>Na<sub>v</sub>1.7/1.8-selective:</i> <a href="/wiki/DSP-2230" title="DSP-2230">DSP-2230</a><sup>§</sup></li> <li><a href="/wiki/Funapide" title="Funapide">Funapide</a><sup>§</sup></li> <li><a href="/wiki/PF-05089771" title="PF-05089771">PF-05089771</a><sup>§</sup></li> <li><a href="/wiki/Suzetrigine" title="Suzetrigine">Suzetrigine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Potassium openers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Flupirtine" title="Flupirtine">Flupirtine</a><sup>‡</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Muscle_relaxant" title="Muscle relaxant">Myorelaxants</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carisoprodol" title="Carisoprodol">Carisoprodol</a></li> <li><a href="/wiki/Chlorzoxazone" title="Chlorzoxazone">Chlorzoxazone</a></li> <li><a href="/wiki/Cyclobenzaprine" title="Cyclobenzaprine">Cyclobenzaprine</a></li> <li><a href="/wiki/Mephenoxalone" title="Mephenoxalone">Mephenoxalone</a></li> <li><a href="/wiki/Methocarbamol" title="Methocarbamol">Methocarbamol</a></li> <li><a href="/wiki/Orphenadrine" title="Orphenadrine">Orphenadrine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Analgecine" title="Analgecine">Analgecine</a></li> <li><a href="/wiki/Analgesic_adjuvant" title="Analgesic adjuvant">Analgesic adjuvant</a></li> <li><a href="/wiki/Bedinvetmab" title="Bedinvetmab">Bedinvetmab</a></li> <li><a href="/wiki/Camphor" title="Camphor">Camphor</a></li> <li><a href="/wiki/Capsaicin" title="Capsaicin">Capsaicin</a></li> <li><a href="/wiki/Clonidine" title="Clonidine">Clonidine</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Menthol" title="Menthol">Menthol</a></li> <li><a href="/wiki/Methoxyflurane" title="Methoxyflurane">Methoxyflurane</a></li> <li><a href="/wiki/Phenazopyridine" title="Phenazopyridine">Phenazopyridine</a></li> <li><a href="/wiki/Proglumide" title="Proglumide">Proglumide</a></li> <li><a href="/wiki/Rimazolium" title="Rimazolium">Rimazolium</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li><sup>‡</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li><sup>†</sup><a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li><sup>§</sup>Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Prostanoid_signaling_modulators402" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Prostanoid_signaling_modulators" title="Template:Prostanoid signaling modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Prostanoid_signaling_modulators" title="Template talk:Prostanoid signaling modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Prostanoid_signaling_modulators" title="Special:EditPage/Template:Prostanoid signaling modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Prostanoid_signaling_modulators402" style="font-size:114%;margin:0 4em"><a href="/wiki/Prostanoid" title="Prostanoid">Prostanoid</a> <a href="/wiki/Cell_signaling" title="Cell signaling">signaling</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">Receptor</a><br /><small>(<a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligands</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_D2_receptor" title="Prostaglandin D2 receptor"><abbr title="Prostaglandin D2 receptor">DP (D<sub>2</sub>)</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin D2 receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_D2_receptor_1" class="mw-redirect" title="Prostaglandin D2 receptor 1"><abbr title="Prostaglandin D2 receptor 1">DP<sub>1</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin D2 receptor 1</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/wiki/Prostaglandin_D2" title="Prostaglandin D2">Prostaglandin D<sub>2</sub></a></li> <li><a href="/wiki/Treprostinil" title="Treprostinil">Treprostinil</a></li></ul> <ul><li><b>Antagonists:</b> <a href="/w/index.php?title=Asapiprant&action=edit&redlink=1" class="new" title="Asapiprant (page does not exist)">Asapiprant</a></li> <li><a href="/wiki/Laropiprant" title="Laropiprant">Laropiprant</a></li> <li><a href="/w/index.php?title=Vidupiprant&action=edit&redlink=1" class="new" title="Vidupiprant (page does not exist)">Vidupiprant</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_D2_receptor_2" class="mw-redirect" title="Prostaglandin D2 receptor 2"><abbr title="Prostaglandin D2 receptor 2">DP<sub>2</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin D2 receptor 2</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/wiki/Indometacin" title="Indometacin">Indometacin</a></li> <li><a href="/wiki/Prostaglandin_D2" title="Prostaglandin D2">Prostaglandin D<sub>2</sub></a></li></ul> <ul><li><b>Antagonists:</b> <a href="/w/index.php?title=ADC-3680&action=edit&redlink=1" class="new" title="ADC-3680 (page does not exist)">ADC-3680</a></li> <li><a href="/w/index.php?title=AZD-1981&action=edit&redlink=1" class="new" title="AZD-1981 (page does not exist)">AZD-1981</a></li> <li><a href="/w/index.php?title=Bay_U3405&action=edit&redlink=1" class="new" title="Bay U3405 (page does not exist)">Bay U3405</a></li> <li><a href="/wiki/Fevipiprant" title="Fevipiprant">Fevipiprant</a></li> <li><a href="/w/index.php?title=MK-1029&action=edit&redlink=1" class="new" title="MK-1029 (page does not exist)">MK-1029</a></li> <li><a href="/w/index.php?title=MK-7246&action=edit&redlink=1" class="new" title="MK-7246 (page does not exist)">MK-7246</a></li> <li><a href="/w/index.php?title=QAV-680&action=edit&redlink=1" class="new" title="QAV-680 (page does not exist)">QAV-680</a></li> <li><a href="/wiki/Ramatroban" title="Ramatroban">Ramatroban</a></li> <li><a href="/wiki/Setipiprant" title="Setipiprant">Setipiprant</a></li> <li><a href="/w/index.php?title=Timapiprant&action=edit&redlink=1" class="new" title="Timapiprant (page does not exist)">Timapiprant</a></li> <li><a href="/w/index.php?title=TM30089&action=edit&redlink=1" class="new" title="TM30089 (page does not exist)">TM30089</a></li> <li><a href="/w/index.php?title=Vidupiprant&action=edit&redlink=1" class="new" title="Vidupiprant (page does not exist)">Vidupiprant</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_E2_receptor" title="Prostaglandin E2 receptor"><abbr title="Prostaglandin E2 receptor">EP (E<sub>2</sub>)</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin E2 receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_EP1_receptor" title="Prostaglandin EP1 receptor"><abbr title="Prostaglandin EP1 receptor">EP<sub>1</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin EP1 receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/wiki/Beraprost" title="Beraprost">Beraprost</a></li> <li><a href="/wiki/Enprostil" title="Enprostil">Enprostil</a></li> <li><a href="/wiki/Iloprost" title="Iloprost">Iloprost (ciloprost)</a></li> <li><a href="/wiki/Latanoprost" title="Latanoprost">Latanoprost</a></li> <li><a href="/wiki/Lubiprostone" title="Lubiprostone">Lubiprostone</a></li> <li><a href="/wiki/Misoprostol" title="Misoprostol">Misoprostol</a></li> <li><a href="/wiki/Prostaglandin_E1" title="Prostaglandin E1">Prostaglandin E<sub>1</sub> (alprostadil)</a></li> <li><a href="/wiki/Prostaglandin_E2" title="Prostaglandin E2">Prostaglandin E<sub>2</sub> (dinoprostone)</a></li> <li><a href="/wiki/Sulprostone" title="Sulprostone">Sulprostone</a></li></ul> <ul><li><b>Antagonists:</b> <a href="/w/index.php?title=AH-6809&action=edit&redlink=1" class="new" title="AH-6809 (page does not exist)">AH-6809</a></li> <li><a href="/w/index.php?title=ONO-8130&action=edit&redlink=1" class="new" title="ONO-8130 (page does not exist)">ONO-8130</a></li> <li><a href="/w/index.php?title=SC-19220&action=edit&redlink=1" class="new" title="SC-19220 (page does not exist)">SC-19220</a></li> <li><a href="/w/index.php?title=SC-51089&action=edit&redlink=1" class="new" title="SC-51089 (page does not exist)">SC-51089</a></li> <li><a href="/w/index.php?title=SC-51322&action=edit&redlink=1" class="new" title="SC-51322 (page does not exist)">SC-51322</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_EP2_receptor" title="Prostaglandin EP2 receptor"><abbr title="Prostaglandin EP2 receptor">EP<sub>2</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin EP2 receptor</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/w/index.php?title=Butaprost&action=edit&redlink=1" class="new" title="Butaprost (page does not exist)">Butaprost</a></li> <li><a href="/wiki/Misoprostol" title="Misoprostol">Misoprostol</a></li> <li><a href="/wiki/Prostaglandin_E1" title="Prostaglandin E1">Prostaglandin E<sub>1</sub> (alprostadil)</a></li> <li><a href="/wiki/Prostaglandin_E2" title="Prostaglandin E2">Prostaglandin E<sub>2</sub> (dinoprostone)</a></li> <li><a href="/wiki/Treprostinil" title="Treprostinil">Treprostinil</a></li></ul> <ul><li><b>Antagonists:</b> <a href="/w/index.php?title=AH-6809&action=edit&redlink=1" class="new" title="AH-6809 (page does not exist)">AH-6809</a></li> <li><a href="/w/index.php?title=PF-04418948&action=edit&redlink=1" class="new" title="PF-04418948 (page does not exist)">PF-04418948</a></li> <li><a href="/w/index.php?title=TG_4-155&action=edit&redlink=1" class="new" title="TG 4-155 (page does not exist)">TG 4-155</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_EP3_receptor" title="Prostaglandin EP3 receptor"><abbr title="Prostaglandin EP3 receptor">EP<sub>3</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin EP3 receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/wiki/Beraprost" title="Beraprost">Beraprost</a></li> <li><a href="/w/index.php?title=Carbacyclin&action=edit&redlink=1" class="new" title="Carbacyclin (page does not exist)">Carbacyclin</a></li> <li><a href="/w/index.php?title=Cicaprost&action=edit&redlink=1" class="new" title="Cicaprost (page does not exist)">Cicaprost</a></li> <li><a href="/wiki/Enprostil" title="Enprostil">Enprostil</a></li> <li><a href="/wiki/Iloprost" title="Iloprost">Iloprost (ciloprost)</a></li> <li><a href="/w/index.php?title=Isocarbacyclin&action=edit&redlink=1" class="new" title="Isocarbacyclin (page does not exist)">Isocarbacyclin</a></li> <li><a href="/wiki/Latanoprost" title="Latanoprost">Latanoprost</a></li> <li><a href="/wiki/Misoprostol" title="Misoprostol">Misoprostol</a></li> <li><a href="/wiki/Prostaglandin_D2" title="Prostaglandin D2">Prostaglandin D<sub>2</sub></a></li> <li><a href="/wiki/Prostaglandin_E1" title="Prostaglandin E1">Prostaglandin E<sub>1</sub> (alprostadil)</a></li> <li><a href="/wiki/Prostaglandin_E2" title="Prostaglandin E2">Prostaglandin E<sub>2</sub> (dinoprostone)</a></li> <li><a href="/w/index.php?title=Remiprostol&action=edit&redlink=1" class="new" title="Remiprostol (page does not exist)">Remiprostol</a></li> <li><a href="/wiki/Ricinoleic_acid" title="Ricinoleic acid">Ricinoleic acid</a></li> <li><a href="/wiki/Sulprostone" title="Sulprostone">Sulprostone</a></li></ul> <ul><li><b>Antagonists:</b> <a href="/w/index.php?title=L-798106&action=edit&redlink=1" class="new" title="L-798106 (page does not exist)">L-798106</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_EP4_receptor" title="Prostaglandin EP4 receptor"><abbr title="Prostaglandin EP4 receptor">EP<sub>4</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin EP4 receptor</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/wiki/Lubiprostone" title="Lubiprostone">Lubiprostone</a></li> <li><a href="/wiki/Misoprostol" title="Misoprostol">Misoprostol</a></li> <li><a href="/wiki/Prostaglandin_E1" title="Prostaglandin E1">Prostaglandin E<sub>1</sub> (alprostadil)</a></li> <li><a href="/wiki/Prostaglandin_E2" title="Prostaglandin E2">Prostaglandin E<sub>2</sub> (dinoprostone)</a></li> <li><a href="/w/index.php?title=TCS-2510&action=edit&redlink=1" class="new" title="TCS-2510 (page does not exist)">TCS-2510</a></li></ul> <ul><li><b>Antagonists:</b> <a href="/wiki/Grapiprant" title="Grapiprant">Grapiprant</a></li> <li><a href="/w/index.php?title=GW-627368&action=edit&redlink=1" class="new" title="GW-627368 (page does not exist)">GW-627368</a></li> <li><a href="/w/index.php?title=L-161982&action=edit&redlink=1" class="new" title="L-161982 (page does not exist)">L-161982</a></li> <li><a href="/w/index.php?title=ONO-AE3-208&action=edit&redlink=1" class="new" title="ONO-AE3-208 (page does not exist)">ONO-AE3-208</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/w/index.php?title=16,16-Dimethyl_Prostaglandin_E2&action=edit&redlink=1" class="new" title="16,16-Dimethyl Prostaglandin E2 (page does not exist)">16,16-Dimethyl Prostaglandin E<sub>2</sub></a></li> <li><a href="/w/index.php?title=Aganepag&action=edit&redlink=1" class="new" title="Aganepag (page does not exist)">Aganepag</a></li> <li><a href="/wiki/Carboprost" title="Carboprost">Carboprost</a></li> <li><a href="/w/index.php?title=Evatanepag&action=edit&redlink=1" class="new" title="Evatanepag (page does not exist)">Evatanepag</a></li> <li><a href="/wiki/Gemeprost" title="Gemeprost">Gemeprost</a></li> <li><a href="/w/index.php?title=Nocloprost&action=edit&redlink=1" class="new" title="Nocloprost (page does not exist)">Nocloprost</a></li> <li><a href="/wiki/Omidenepag" title="Omidenepag">Omidenepag</a></li> <li><a href="/wiki/Prostaglandin_F2%CE%B1" class="mw-redirect" title="Prostaglandin F2α">Prostaglandin F<sub>2α</sub> (dinoprost)</a></li> <li><a href="/w/index.php?title=Simenepag&action=edit&redlink=1" class="new" title="Simenepag (page does not exist)">Simenepag</a></li> <li><a href="/w/index.php?title=Taprenepag&action=edit&redlink=1" class="new" title="Taprenepag (page does not exist)">Taprenepag</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_F_receptor" title="Prostaglandin F receptor"><abbr title="Prostaglandin F receptor">FP (F<sub>2α</sub>)</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin F receptor</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/wiki/Alfaprostol" title="Alfaprostol">Alfaprostol</a></li> <li><a href="/wiki/Bimatoprost" title="Bimatoprost">Bimatoprost</a></li> <li><a href="/wiki/Carboprost" title="Carboprost">Carboprost</a></li> <li><a href="/wiki/Cloprostenol" title="Cloprostenol">Cloprostenol</a></li> <li><a href="/wiki/Enprostil" title="Enprostil">Enprostil</a></li> <li><a href="/w/index.php?title=Fluprostenol&action=edit&redlink=1" class="new" title="Fluprostenol (page does not exist)">Fluprostenol</a></li> <li><a href="/wiki/Latanoprost" title="Latanoprost">Latanoprost</a></li> <li><a href="/wiki/Prostaglandin_D2" title="Prostaglandin D2">Prostaglandin D<sub>2</sub></a></li> <li><a href="/wiki/Prostaglandin_F2%CE%B1" class="mw-redirect" title="Prostaglandin F2α">Prostaglandin F<sub>2α</sub> (dinoprost)</a></li> <li><a href="/w/index.php?title=Sulotroban&action=edit&redlink=1" class="new" title="Sulotroban (page does not exist)">Sulotroban</a></li> <li><a href="/wiki/Tafluprost" title="Tafluprost">Tafluprost</a></li> <li><a href="/wiki/Travoprost" title="Travoprost">Travoprost</a></li> <li><a href="/wiki/Unoprostone" title="Unoprostone">Unoprostone</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostacyclin_receptor" title="Prostacyclin receptor"><abbr title="Prostacyclin receptor">IP (I<sub>2</sub>)</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostacyclin receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/w/index.php?title=ACT-333679&action=edit&redlink=1" class="new" title="ACT-333679 (page does not exist)">ACT-333679</a></li> <li><a href="/w/index.php?title=AFP-07&action=edit&redlink=1" class="new" title="AFP-07 (page does not exist)">AFP-07</a></li> <li><a href="/wiki/Beraprost" title="Beraprost">Beraprost</a></li> <li><a href="/w/index.php?title=BMY-45778&action=edit&redlink=1" class="new" title="BMY-45778 (page does not exist)">BMY-45778</a></li> <li><a href="/w/index.php?title=Carbacyclin&action=edit&redlink=1" class="new" title="Carbacyclin (page does not exist)">Carbacyclin</a></li> <li><a href="/w/index.php?title=Cicaprost&action=edit&redlink=1" class="new" title="Cicaprost (page does not exist)">Cicaprost</a></li> <li><a href="/wiki/Iloprost" title="Iloprost">Iloprost (ciloprost)</a></li> <li><a href="/w/index.php?title=Isocarbacyclin&action=edit&redlink=1" class="new" title="Isocarbacyclin (page does not exist)">Isocarbacyclin</a></li> <li><a href="/w/index.php?title=MRE-269&action=edit&redlink=1" class="new" title="MRE-269 (page does not exist)">MRE-269</a></li> <li><a href="/w/index.php?title=NS-304&action=edit&redlink=1" class="new" title="NS-304 (page does not exist)">NS-304</a></li> <li><a href="/wiki/Prostacyclin" title="Prostacyclin">Prostacyclin (prostaglandin I<sub>2</sub>, epoprostenol)</a></li> <li><a href="/wiki/Prostaglandin_E1" title="Prostaglandin E1">Prostaglandin E<sub>1</sub> (alprostadil)</a></li> <li><a href="/w/index.php?title=Ralinepag&action=edit&redlink=1" class="new" title="Ralinepag (page does not exist)">Ralinepag</a></li> <li><a href="/wiki/Selexipag" title="Selexipag">Selexipag</a></li> <li><a href="/w/index.php?title=Taprostene&action=edit&redlink=1" class="new" title="Taprostene (page does not exist)">Taprostene</a></li> <li><a href="/w/index.php?title=TRA-418&action=edit&redlink=1" class="new" title="TRA-418 (page does not exist)">TRA-418</a></li> <li><a href="/wiki/Treprostinil" title="Treprostinil">Treprostinil</a></li></ul> <ul><li><b>Antagonists:</b> <a href="/w/index.php?title=RO1138452&action=edit&redlink=1" class="new" title="RO1138452 (page does not exist)">RO1138452</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Thromboxane_receptor" title="Thromboxane receptor"><abbr title="Thromboxane receptor">TP (TX<sub>A2</sub>)</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Thromboxane receptor</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/w/index.php?title=Carbocyclic_thromboxane_A2&action=edit&redlink=1" class="new" title="Carbocyclic thromboxane A2 (page does not exist)">Carbocyclic thromboxane A<sub>2</sub></a></li> <li><a href="/w/index.php?title=I-BOP&action=edit&redlink=1" class="new" title="I-BOP (page does not exist)">I-BOP</a></li> <li><a href="/wiki/Thromboxane_A2" title="Thromboxane A2">Thromboxane A<sub>2</sub></a></li> <li><a href="/wiki/U-46619" class="mw-redirect" title="U-46619">U-46619</a></li> <li><a href="/w/index.php?title=Vapiprost&action=edit&redlink=1" class="new" title="Vapiprost (page does not exist)">Vapiprost</a></li></ul> <ul><li><b>Antagonists:</b> <a href="/wiki/12-Hydroxyeicosatetraenoic_acid" title="12-Hydroxyeicosatetraenoic acid">12-HETE</a></li> <li><a href="/w/index.php?title=13-APA&action=edit&redlink=1" class="new" title="13-APA (page does not exist)">13-APA</a></li> <li><a href="/w/index.php?title=AA-2414&action=edit&redlink=1" class="new" title="AA-2414 (page does not exist)">AA-2414</a></li> <li><a href="/wiki/Argatroban" title="Argatroban">Argatroban</a></li> <li><a href="/w/index.php?title=Bay_U3405&action=edit&redlink=1" class="new" title="Bay U3405 (page does not exist)">Bay U3405</a></li> <li><a href="/w/index.php?title=BMS-180,291&action=edit&redlink=1" class="new" title="BMS-180,291 (page does not exist)">BMS-180,291</a></li> <li><a href="/w/index.php?title=Daltroban&action=edit&redlink=1" class="new" title="Daltroban (page does not exist)">Daltroban</a></li> <li><a href="/w/index.php?title=Domitroban&action=edit&redlink=1" class="new" title="Domitroban (page does not exist)">Domitroban</a></li> <li><a href="/w/index.php?title=EP-045&action=edit&redlink=1" class="new" title="EP-045 (page does not exist)">EP-045</a></li> <li><a href="/w/index.php?title=GR-32191&action=edit&redlink=1" class="new" title="GR-32191 (page does not exist)">GR-32191</a></li> <li><a href="/w/index.php?title=ICI-185282&action=edit&redlink=1" class="new" title="ICI-185282 (page does not exist)">ICI-185282</a></li> <li><a href="/w/index.php?title=ICI-192605&action=edit&redlink=1" class="new" title="ICI-192605 (page does not exist)">ICI-192605</a></li> <li><a href="/wiki/Ifetroban" title="Ifetroban">Ifetroban</a></li> <li><a href="/w/index.php?title=Imitrodast&action=edit&redlink=1" class="new" title="Imitrodast (page does not exist)">Imitrodast</a></li> <li><a href="/w/index.php?title=L-655240&action=edit&redlink=1" class="new" title="L-655240 (page does not exist)">L-655240</a></li> <li><a href="/w/index.php?title=L-670596&action=edit&redlink=1" class="new" title="L-670596 (page does not exist)">L-670596</a></li> <li><a href="/w/index.php?title=Linotroban&action=edit&redlink=1" class="new" title="Linotroban (page does not exist)">Linotroban</a></li> <li><a href="/w/index.php?title=Mipitroban&action=edit&redlink=1" class="new" title="Mipitroban (page does not exist)">Mipitroban</a></li> <li><a href="/w/index.php?title=ONO-3708&action=edit&redlink=1" class="new" title="ONO-3708 (page does not exist)">ONO-3708</a></li> <li><a href="/w/index.php?title=ONO-11120&action=edit&redlink=1" class="new" title="ONO-11120 (page does not exist)">ONO-11120</a></li> <li><a href="/wiki/Picotamide" title="Picotamide">Picotamide</a></li> <li><a href="/w/index.php?title=Pinane_thromboxane_A2&action=edit&redlink=1" class="new" title="Pinane thromboxane A2 (page does not exist)">Pinane thromboxane A<sub>2</sub></a></li> <li><a href="/wiki/Ramatroban" title="Ramatroban">Ramatroban</a></li> <li><a href="/w/index.php?title=Ridogrel&action=edit&redlink=1" class="new" title="Ridogrel (page does not exist)">Ridogrel</a></li> <li><a href="/w/index.php?title=S-145&action=edit&redlink=1" class="new" title="S-145 (page does not exist)">S-145</a></li> <li><a href="/w/index.php?title=Samixogrel&action=edit&redlink=1" class="new" title="Samixogrel (page does not exist)">Samixogrel</a></li> <li><a href="/wiki/Seratrodast" title="Seratrodast">Seratrodast</a></li> <li><a href="/w/index.php?title=SQ-28,668&action=edit&redlink=1" class="new" title="SQ-28,668 (page does not exist)">SQ-28,668</a></li> <li><a href="/w/index.php?title=SQ-29,548&action=edit&redlink=1" class="new" title="SQ-29,548 (page does not exist)">SQ-29,548</a></li> <li><a href="/w/index.php?title=Sulotroban&action=edit&redlink=1" class="new" title="Sulotroban (page does not exist)">Sulotroban</a></li> <li><a href="/wiki/Terbogrel" title="Terbogrel">Terbogrel</a></li> <li><a href="/wiki/Terutroban" title="Terutroban">Terutroban</a></li> <li><a href="/w/index.php?title=TRA-418&action=edit&redlink=1" class="new" title="TRA-418 (page does not exist)">TRA-418</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Arbaprostil&action=edit&redlink=1" class="new" title="Arbaprostil (page does not exist)">Arbaprostil</a></li> <li><a href="/w/index.php?title=Ataprost&action=edit&redlink=1" class="new" title="Ataprost (page does not exist)">Ataprost</a></li> <li><a href="/w/index.php?title=Ciprostene&action=edit&redlink=1" class="new" title="Ciprostene (page does not exist)">Ciprostene</a></li> <li><a href="/w/index.php?title=Clinprost&action=edit&redlink=1" class="new" title="Clinprost (page does not exist)">Clinprost</a></li> <li><a href="/w/index.php?title=Cobiprostone&action=edit&redlink=1" class="new" title="Cobiprostone (page does not exist)">Cobiprostone</a></li> <li><a href="/w/index.php?title=Delprostenate&action=edit&redlink=1" class="new" title="Delprostenate (page does not exist)">Delprostenate</a></li> <li><a href="/w/index.php?title=Deprostil&action=edit&redlink=1" class="new" title="Deprostil (page does not exist)">Deprostil</a></li> <li><a href="/w/index.php?title=Dimoxaprost&action=edit&redlink=1" class="new" title="Dimoxaprost (page does not exist)">Dimoxaprost</a></li> <li><a href="/w/index.php?title=Doxaprost&action=edit&redlink=1" class="new" title="Doxaprost (page does not exist)">Doxaprost</a></li> <li><a href="/w/index.php?title=Ecraprost&action=edit&redlink=1" class="new" title="Ecraprost (page does not exist)">Ecraprost</a></li> <li><a href="/w/index.php?title=Eganoprost&action=edit&redlink=1" class="new" title="Eganoprost (page does not exist)">Eganoprost</a></li> <li><a href="/w/index.php?title=Enisoprost&action=edit&redlink=1" class="new" title="Enisoprost (page does not exist)">Enisoprost</a></li> <li><a href="/w/index.php?title=Eptaloprost&action=edit&redlink=1" class="new" title="Eptaloprost (page does not exist)">Eptaloprost</a></li> <li><a href="/w/index.php?title=Esuberaprost&action=edit&redlink=1" class="new" title="Esuberaprost (page does not exist)">Esuberaprost</a></li> <li><a href="/w/index.php?title=Etiproston&action=edit&redlink=1" class="new" title="Etiproston (page does not exist)">Etiproston</a></li> <li><a href="/w/index.php?title=Fenprostalene&action=edit&redlink=1" class="new" title="Fenprostalene (page does not exist)">Fenprostalene</a></li> <li><a href="/w/index.php?title=Flunoprost&action=edit&redlink=1" class="new" title="Flunoprost (page does not exist)">Flunoprost</a></li> <li><a href="/w/index.php?title=Froxiprost&action=edit&redlink=1" class="new" title="Froxiprost (page does not exist)">Froxiprost</a></li> <li><a href="/w/index.php?title=Lanproston&action=edit&redlink=1" class="new" title="Lanproston (page does not exist)">Lanproston</a></li> <li><a href="/w/index.php?title=Limaprost&action=edit&redlink=1" class="new" title="Limaprost (page does not exist)">Limaprost</a></li> <li><a href="/w/index.php?title=Luprostiol&action=edit&redlink=1" class="new" title="Luprostiol (page does not exist)">Luprostiol</a></li> <li><a href="/w/index.php?title=Meteneprost&action=edit&redlink=1" class="new" title="Meteneprost (page does not exist)">Meteneprost</a></li> <li><a href="/w/index.php?title=Mexiprostil&action=edit&redlink=1" class="new" title="Mexiprostil (page does not exist)">Mexiprostil</a></li> <li><a href="/w/index.php?title=Naxaprostene&action=edit&redlink=1" class="new" title="Naxaprostene (page does not exist)">Naxaprostene</a></li> <li><a href="/w/index.php?title=Nileprost&action=edit&redlink=1" class="new" title="Nileprost (page does not exist)">Nileprost</a></li> <li><a href="/w/index.php?title=Nocloprost&action=edit&redlink=1" class="new" title="Nocloprost (page does not exist)">Nocloprost</a></li> <li><a href="/w/index.php?title=Ornoprostil&action=edit&redlink=1" class="new" title="Ornoprostil (page does not exist)">Ornoprostil</a></li> <li><a href="/w/index.php?title=Oxoprostol&action=edit&redlink=1" class="new" title="Oxoprostol (page does not exist)">Oxoprostol</a></li> <li><a href="/w/index.php?title=Penprostene&action=edit&redlink=1" class="new" title="Penprostene (page does not exist)">Penprostene</a></li> <li><a href="/w/index.php?title=Pimilprost&action=edit&redlink=1" class="new" title="Pimilprost (page does not exist)">Pimilprost</a></li> <li><a href="/w/index.php?title=Piriprost&action=edit&redlink=1" class="new" title="Piriprost (page does not exist)">Piriprost</a></li> <li><a href="/w/index.php?title=Posaraprost&action=edit&redlink=1" class="new" title="Posaraprost (page does not exist)">Posaraprost</a></li> <li><a href="/w/index.php?title=Prostalene&action=edit&redlink=1" class="new" title="Prostalene (page does not exist)">Prostalene</a></li> <li><a href="/w/index.php?title=Rioprostil&action=edit&redlink=1" class="new" title="Rioprostil (page does not exist)">Rioprostil</a></li> <li><a href="/w/index.php?title=Rivenprost&action=edit&redlink=1" class="new" title="Rivenprost (page does not exist)">Rivenprost</a></li> <li><a href="/w/index.php?title=Rosaprostol&action=edit&redlink=1" class="new" title="Rosaprostol (page does not exist)">Rosaprostol</a></li> <li><a href="/w/index.php?title=Spiriprostil&action=edit&redlink=1" class="new" title="Spiriprostil (page does not exist)">Spiriprostil</a></li> <li><a href="/w/index.php?title=Tiaprost&action=edit&redlink=1" class="new" title="Tiaprost (page does not exist)">Tiaprost</a></li> <li><a href="/w/index.php?title=Tilsuprost&action=edit&redlink=1" class="new" title="Tilsuprost (page does not exist)">Tilsuprost</a></li> <li><a href="/w/index.php?title=Tiprostanide&action=edit&redlink=1" class="new" title="Tiprostanide (page does not exist)">Tiprostanide</a></li> <li><a href="/w/index.php?title=Trimoprostil&action=edit&redlink=1" class="new" title="Trimoprostil (page does not exist)">Trimoprostil</a></li> <li><a href="/w/index.php?title=Viprostol&action=edit&redlink=1" class="new" title="Viprostol (page does not exist)">Viprostol</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Enzyme" title="Enzyme">Enzyme</a><br /><small>(<a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">inhibitors</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Cyclooxygenase" title="Cyclooxygenase"><abbr title="Cyclooxygenase">COX</abbr><br />(<abbr title="prostaglandin G/H synthase">PTGS</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Salicylic acids:</i> <a href="/wiki/Aloxiprin" title="Aloxiprin">Aloxiprin</a></li> <li><a href="/wiki/Aspirin" title="Aspirin">Aspirin (acetylsalicylic acid)</a></li> <li><a href="/wiki/Benorilate" title="Benorilate">Benorilate (benorylate)</a></li> <li><a href="/wiki/Carbasalate_calcium" title="Carbasalate calcium">Carbasalate calcium</a></li> <li><a href="/wiki/Diflunisal" title="Diflunisal">Diflunisal</a></li> <li><a href="/wiki/Dipyrocetyl" title="Dipyrocetyl">Dipyrocetyl</a></li> <li><a href="/wiki/Ethenzamide" title="Ethenzamide">Ethenzamide</a></li> <li><a href="/wiki/Guacetisal" title="Guacetisal">Guacetisal</a></li> <li><a href="/wiki/Magnesium_salicylate" title="Magnesium salicylate">Magnesium salicylate</a></li> <li><a href="/wiki/Mesalazine" title="Mesalazine">Mesalazine (5-aminosalicylic acid)</a></li> <li><a href="/wiki/Methyl_salicylate" title="Methyl salicylate">Methyl salicylate</a></li> <li><a href="/w/index.php?title=Salacetamide&action=edit&redlink=1" class="new" title="Salacetamide (page does not exist)">Salacetamide</a></li> <li><a href="/wiki/Salicin" title="Salicin">Salicin</a></li> <li><a href="/wiki/Salicylamide" title="Salicylamide">Salicylamide</a></li> <li><a href="/wiki/Salicylate" class="mw-redirect" title="Salicylate">Salicylate (salicylic acid)</a></li> <li><a href="/wiki/Salsalate" title="Salsalate">Salsalate</a></li> <li><a href="/wiki/Sodium_salicylate" title="Sodium salicylate">Sodium salicylate</a></li> <li><a href="/wiki/Triflusal" title="Triflusal">Triflusal</a>; <i>Acetic acids:</i> <a href="/wiki/Aceclofenac" title="Aceclofenac">Aceclofenac</a></li> <li><a href="/wiki/Acemetacin" title="Acemetacin">Acemetacin</a></li> <li><a href="/w/index.php?title=Aclofenac&action=edit&redlink=1" class="new" title="Aclofenac (page does not exist)">Aclofenac</a></li> <li><a href="/wiki/Amfenac" title="Amfenac">Amfenac</a></li> <li><a href="/wiki/Alclofenac" title="Alclofenac">Alclofenac</a></li> <li><a href="/wiki/Bendazac" title="Bendazac">Bendazac</a></li> <li><a href="/wiki/Bromfenac" title="Bromfenac">Bromfenac</a></li> <li><a href="/wiki/Bufexamac" title="Bufexamac">Bufexamac</a></li> <li><a href="/wiki/Bumadizone" title="Bumadizone">Bumadizone</a></li> <li><a href="/w/index.php?title=Cinmetacin&action=edit&redlink=1" class="new" title="Cinmetacin (page does not exist)">Cinmetacin</a></li> <li><a href="/w/index.php?title=Clometacin&action=edit&redlink=1" class="new" title="Clometacin (page does not exist)">Clometacin</a></li> <li><a href="/wiki/Diclofenac" title="Diclofenac">Diclofenac</a></li> <li><a href="/wiki/Difenpiramide" title="Difenpiramide">Difenpiramide</a></li> <li><a href="/wiki/Etodolac" title="Etodolac">Etodolac</a></li> <li><a href="/wiki/Felbinac" title="Felbinac">Felbinac</a></li> <li><a href="/wiki/Fenclofenac" title="Fenclofenac">Fenclofenac</a></li> <li><a href="/wiki/Fentiazac" title="Fentiazac">Fentiazac</a></li> <li><a href="/wiki/Glucametacin" title="Glucametacin">Glucametacin</a></li> <li><a href="/wiki/Indometacin" title="Indometacin">Indometacin (indomethacin)</a></li> <li><a href="/wiki/Indometacin_farnesil" title="Indometacin farnesil">Indometacin farnesil</a></li> <li><a href="/wiki/Ketorolac" title="Ketorolac">Ketorolac</a></li> <li><a href="/wiki/Lonazolac" title="Lonazolac">Lonazolac</a></li> <li><a href="/wiki/Mofezolac" title="Mofezolac">Mofezolac</a></li> <li><a href="/wiki/Nabumetone" title="Nabumetone">Nabumetone</a></li> <li><a href="/wiki/Oxametacin" title="Oxametacin">Oxametacin</a></li> <li><a href="/w/index.php?title=Oxindanac&action=edit&redlink=1" class="new" title="Oxindanac (page does not exist)">Oxindanac</a></li> <li><a href="/wiki/Proglumetacin" title="Proglumetacin">Proglumetacin</a></li> <li><a href="/wiki/Sulindac" title="Sulindac">Sulindac</a></li> <li><a href="/w/index.php?title=Sulindac_sulfide&action=edit&redlink=1" class="new" title="Sulindac sulfide (page does not exist)">Sulindac sulfide</a></li> <li><a href="/wiki/Tolmetin" title="Tolmetin">Tolmetin</a></li> <li><a href="/w/index.php?title=Zidometacin&action=edit&redlink=1" class="new" title="Zidometacin (page does not exist)">Zidometacin</a></li> <li><a href="/wiki/Zomepirac" title="Zomepirac">Zomepirac</a>; <i>Propionic acids:</i> <a href="/wiki/Alminoprofen" title="Alminoprofen">Alminoprofen</a></li> <li><a href="/wiki/Benoxaprofen" title="Benoxaprofen">Benoxaprofen</a></li> <li><a href="/w/index.php?title=Bucloxic_acid&action=edit&redlink=1" class="new" title="Bucloxic acid (page does not exist)">Bucloxic acid (blucloxate)</a></li> <li><a href="/w/index.php?title=Butibufen&action=edit&redlink=1" class="new" title="Butibufen (page does not exist)">Butibufen</a></li> <li><a href="/wiki/Carprofen" title="Carprofen">Carprofen</a></li> <li><a href="/wiki/Dexibuprofen" title="Dexibuprofen">Dexibuprofen</a></li> <li><a href="/w/index.php?title=Dexindoprofen&action=edit&redlink=1" class="new" title="Dexindoprofen (page does not exist)">Dexindoprofen</a></li> <li><a href="/wiki/Dexketoprofen" title="Dexketoprofen">Dexketoprofen</a></li> <li><a href="/wiki/Fenbufen" title="Fenbufen">Fenbufen</a></li> <li><a href="/wiki/Fenoprofen" title="Fenoprofen">Fenoprofen</a></li> <li><a href="/wiki/Flunoxaprofen" title="Flunoxaprofen">Flunoxaprofen</a></li> <li><a href="/wiki/Flurbiprofen" title="Flurbiprofen">Flurbiprofen</a></li> <li><a href="/wiki/Ibuprofen" title="Ibuprofen">Ibuprofen</a></li> <li><a href="/wiki/Ibuproxam" title="Ibuproxam">Ibuproxam</a></li> <li><a href="/wiki/Indoprofen" title="Indoprofen">Indoprofen</a></li> <li><a href="/wiki/Ketoprofen" title="Ketoprofen">Ketoprofen</a></li> <li><a href="/wiki/Loxoprofen" title="Loxoprofen">Loxoprofen</a></li> <li><a href="/wiki/Miroprofen" title="Miroprofen">Miroprofen</a></li> <li><a href="/wiki/Naproxen" title="Naproxen">Naproxen</a></li> <li><a href="/wiki/Naproxcinod" title="Naproxcinod">Naproxcinod</a></li> <li><a href="/wiki/Oxaprozin" title="Oxaprozin">Oxaprozin</a></li> <li><a href="/wiki/Pirprofen" title="Pirprofen">Pirprofen</a></li> <li><a href="/wiki/Pranoprofen" title="Pranoprofen">Pranoprofen</a></li> <li><a href="/wiki/Suprofen" title="Suprofen">Suprofen</a></li> <li><a href="/wiki/Tarenflurbil" title="Tarenflurbil">Tarenflurbil</a></li> <li><a href="/wiki/Tepoxalin" title="Tepoxalin">Tepoxalin</a></li> <li><a href="/wiki/Tiaprofenic_acid" title="Tiaprofenic acid">Tiaprofenic acid (tiaprofenate)</a></li> <li><a href="/wiki/Vedaprofen" title="Vedaprofen">Vedaprofen</a>; <i>Anthranilic acids (fenamic acids):</i> <a href="/wiki/Etofenamate" title="Etofenamate">Etofenamic acid (etofenamate)</a></li> <li><a href="/w/index.php?title=Floctafenic_acid&action=edit&redlink=1" class="new" title="Floctafenic acid (page does not exist)">Floctafenic acid (floctafenate)</a></li> <li><a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid (flufenamate)</a></li> <li><a href="/wiki/Meclofenamic_acid" title="Meclofenamic acid">Meclofenamic acid (meclofenamate)</a></li> <li><a href="/wiki/Mefenamic_acid" title="Mefenamic acid">Mefenamic acid (mefenamate)</a></li> <li><a href="/wiki/Morniflumate" title="Morniflumate">Morniflumic acid (morniflumate)</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid (niflumate)</a></li> <li><a href="/w/index.php?title=Talinflumic_acid&action=edit&redlink=1" class="new" title="Talinflumic acid (page does not exist)">Talinflumic acid (talinflumate)</a></li> <li><a href="/wiki/Tolfenamic_acid" title="Tolfenamic acid">Tolfenamic acid (tolfenamate)</a>; <i>Pyrazolones:</i> <a href="/wiki/Azapropazone" title="Azapropazone">Azapropazone</a></li> <li><a href="/wiki/Dipyrone" class="mw-redirect" title="Dipyrone">Dipyrone</a></li> <li><a href="/wiki/Isopyrin" class="mw-redirect" title="Isopyrin">Isopyrin</a></li> <li><a href="/wiki/Oxyphenbutazone" title="Oxyphenbutazone">Oxyphenbutazone</a></li> <li><a href="/wiki/Phenylbutazone" title="Phenylbutazone">Phenylbutazone</a>; <i>Enolic acids (oxicams):</i> <a href="/wiki/Ampiroxicam" title="Ampiroxicam">Ampiroxicam</a></li> <li><a href="/wiki/Droxicam" title="Droxicam">Droxicam</a></li> <li><a href="/w/index.php?title=Enolicam&action=edit&redlink=1" class="new" title="Enolicam (page does not exist)">Enolicam</a></li> <li><a href="/wiki/Isoxicam" title="Isoxicam">Isoxicam</a></li> <li><a href="/wiki/Lornoxicam" title="Lornoxicam">Lornoxicam</a></li> <li><a href="/wiki/Meloxicam" title="Meloxicam">Meloxicam</a></li> <li><a href="/wiki/Piroxicam" title="Piroxicam">Piroxicam</a></li> <li><a href="/wiki/Tenoxicam" title="Tenoxicam">Tenoxicam</a>; <i>4-Aminoquinolines:</i> <a href="/wiki/Antrafenine" title="Antrafenine">Antrafenine</a></li> <li><a href="/wiki/Floctafenine" title="Floctafenine">Floctafenine</a></li> <li><a href="/wiki/Glafenine" title="Glafenine">Glafenine</a>; <i>Quinazolines:</i> <a href="/wiki/Fluproquazone" title="Fluproquazone">Fluproquazone</a></li> <li><a href="/wiki/Proquazone" title="Proquazone">Proquazone</a>; <i>Aminonicotinic acids:</i> <a href="/wiki/Clonixeril" class="mw-redirect" title="Clonixeril">Clonixeril</a></li> <li><a href="/wiki/Clonixin" title="Clonixin">Clonixin</a></li> <li><a href="/wiki/Flunixin" title="Flunixin">Flunixin</a>; <i>Sulfonanilides:</i> <a href="/w/index.php?title=Flosulide&action=edit&redlink=1" class="new" title="Flosulide (page does not exist)">Flosulide</a></li> <li><a href="/wiki/Nimesulide" title="Nimesulide">Nimesulide</a>; <i>Aminophenols (anilines):</i> <a href="/wiki/Acetanilide" title="Acetanilide">Acetanilide</a></li> <li><a href="/wiki/AM404" title="AM404">AM-404 (N-arachidonoylaminophenol)</a></li> <li><a href="/wiki/Bucetin" title="Bucetin">Bucetin</a></li> <li><a href="/wiki/Paracetamol" title="Paracetamol">Paracetamol (acetaminophen)</a></li> <li><a href="/w/index.php?title=Parapropamol&action=edit&redlink=1" class="new" title="Parapropamol (page does not exist)">Parapropamol</a></li> <li><a href="/wiki/Phenacetin" title="Phenacetin">Phenacetin</a></li> <li><a href="/wiki/Propacetamol" title="Propacetamol">Propacetamol</a>; <i>Selective COX-2 inhibitors (coxibs):</i> <a href="/wiki/Apricoxib" title="Apricoxib">Apricoxib</a></li> <li><a class="mw-selflink selflink">Celecoxib</a></li> <li><a href="/wiki/Cimicoxib" title="Cimicoxib">Cimicoxib</a></li> <li><a href="/wiki/Deracoxib" title="Deracoxib">Deracoxib</a></li> <li><a href="/wiki/Etoricoxib" title="Etoricoxib">Etoricoxib</a></li> <li><a href="/wiki/Firocoxib" title="Firocoxib">Firocoxib</a></li> <li><a href="/wiki/Lumiracoxib" title="Lumiracoxib">Lumiracoxib</a></li> <li><a href="/wiki/Mavacoxib" title="Mavacoxib">Mavacoxib</a></li> <li><a href="/wiki/Parecoxib" title="Parecoxib">Parecoxib</a></li> <li><a href="/wiki/Polmacoxib" title="Polmacoxib">Polmacoxib</a></li> <li><a href="/wiki/Robenacoxib" title="Robenacoxib">Robenacoxib</a></li> <li><a href="/wiki/Rofecoxib" title="Rofecoxib">Rofecoxib</a></li> <li><a href="/wiki/Tilmacoxib" title="Tilmacoxib">Tilmacoxib</a></li> <li><a href="/wiki/Valdecoxib" title="Valdecoxib">Valdecoxib</a>; <i>Others/unsorted:</i> <a href="/wiki/Anitrazafen" title="Anitrazafen">Anitrazafen</a></li> <li><a href="/w/index.php?title=Clobuzarit&action=edit&redlink=1" class="new" title="Clobuzarit (page does not exist)">Clobuzarit</a></li> <li><a href="/wiki/Curcumin" title="Curcumin">Curcumin</a></li> <li><a href="/w/index.php?title=DuP-697&action=edit&redlink=1" class="new" title="DuP-697 (page does not exist)">DuP-697</a></li> <li><a href="/w/index.php?title=FK-3311&action=edit&redlink=1" class="new" title="FK-3311 (page does not exist)">FK-3311</a></li> <li><a href="/wiki/Flumizole" title="Flumizole">Flumizole</a></li> <li><a href="/w/index.php?title=FR-122047&action=edit&redlink=1" class="new" title="FR-122047 (page does not exist)">FR-122047</a></li> <li><a href="/wiki/Glimepiride" title="Glimepiride">Glimepiride</a></li> <li><a href="/wiki/Hyperforin" title="Hyperforin">Hyperforin</a></li> <li><a href="/w/index.php?title=Itazigrel&action=edit&redlink=1" class="new" title="Itazigrel (page does not exist)">Itazigrel</a></li> <li><a href="/w/index.php?title=L-655240&action=edit&redlink=1" class="new" title="L-655240 (page does not exist)">L-655240</a></li> <li><a href="/w/index.php?title=L-670596&action=edit&redlink=1" class="new" title="L-670596 (page does not exist)">L-670596</a></li> <li><a href="/wiki/Licofelone" title="Licofelone">Licofelone</a></li> <li><a href="/wiki/Menatetrenone" title="Menatetrenone">Menatetrenone (vitamin K<sub>2</sub>)</a></li> <li><a href="/w/index.php?title=NCX-466&action=edit&redlink=1" class="new" title="NCX-466 (page does not exist)">NCX-466</a></li> <li><a href="/w/index.php?title=NCX-4040&action=edit&redlink=1" class="new" title="NCX-4040 (page does not exist)">NCX-4040</a></li> <li><a href="/wiki/NS-398" title="NS-398">NS-398</a></li> <li><a href="/wiki/Pamicogrel" title="Pamicogrel">Pamicogrel</a></li> <li><a href="/wiki/Resveratrol" title="Resveratrol">Resveratrol</a></li> <li><a href="/w/index.php?title=Romazarit&action=edit&redlink=1" class="new" title="Romazarit (page does not exist)">Romazarit</a></li> <li><a href="/wiki/Rosmarinic_acid" title="Rosmarinic acid">Rosmarinic acid</a></li> <li><a href="/wiki/Rutecarpine" title="Rutecarpine">Rutecarpine</a></li> <li><a href="/w/index.php?title=Satigrel&action=edit&redlink=1" class="new" title="Satigrel (page does not exist)">Satigrel</a></li> <li><a href="/w/index.php?title=SC-236&action=edit&redlink=1" class="new" title="SC-236 (page does not exist)">SC-236</a></li> <li><a href="/w/index.php?title=SC-560&action=edit&redlink=1" class="new" title="SC-560 (page does not exist)">SC-560</a></li> <li><a href="/w/index.php?title=SC-58125&action=edit&redlink=1" class="new" title="SC-58125 (page does not exist)">SC-58125</a></li> <li><a href="/wiki/Tenidap" title="Tenidap">Tenidap</a></li> <li><a href="/w/index.php?title=Tiflamizole&action=edit&redlink=1" class="new" title="Tiflamizole (page does not exist)">Tiflamizole</a></li> <li><a href="/w/index.php?title=Timegadine&action=edit&redlink=1" class="new" title="Timegadine (page does not exist)">Timegadine</a></li> <li><a href="/w/index.php?title=Trifenagrel&action=edit&redlink=1" class="new" title="Trifenagrel (page does not exist)">Trifenagrel</a></li> <li><a href="/w/index.php?title=Tropesin&action=edit&redlink=1" class="new" title="Tropesin (page does not exist)">Tropesin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_D_synthase" class="mw-redirect" title="Prostaglandin D synthase"><abbr title="Prostaglandin D synthase">PGD<sub>2</sub>S</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin D synthase</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Retinoid" title="Retinoid">Retinoids</a></li> <li><a href="/wiki/Selenium" title="Selenium">Selenium</a> (<a href="/wiki/Selenium_tetrachloride" title="Selenium tetrachloride">selenium tetrachloride</a>, <a href="/wiki/Sodium_selenite" title="Sodium selenite">sodium selenite</a>, <a href="/wiki/Selenium_disulfide" title="Selenium disulfide">selenium disulfide</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_E_synthase" title="Prostaglandin E synthase"><abbr title="Prostaglandin E synthase">PGES</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin E synthase</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"><a href="/w/index.php?title=HQL-79&action=edit&redlink=1" class="new" title="HQL-79 (page does not exist)">HQL-79</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostaglandin_F_synthase" title="Prostaglandin F synthase"><abbr title="Prostaglandin F synthase">PGFS</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostaglandin F synthase</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"><a href="/wiki/Bimatoprost" title="Bimatoprost">Bimatoprost</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Prostacyclin_synthase" title="Prostacyclin synthase"><abbr title="Prostacyclin synthase">PGI<sub>2</sub>S</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Prostacyclin synthase</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"><a href="/wiki/Tranylcypromine" title="Tranylcypromine">Tranylcypromine</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Thromboxane_A_synthase" class="mw-redirect" title="Thromboxane A synthase"><abbr title="Thromboxane A synthase">TXAS</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Thromboxane A synthase</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Camonagrel&action=edit&redlink=1" class="new" title="Camonagrel (page does not exist)">Camonagrel</a></li> <li><a href="/w/index.php?title=Dazmegrel&action=edit&redlink=1" class="new" title="Dazmegrel (page does not exist)">Dazmegrel</a></li> <li><a href="/wiki/Dazoxiben" title="Dazoxiben">Dazoxiben</a></li> <li><a href="/wiki/Furegrelate" title="Furegrelate">Furegrelate</a></li> <li><a href="/w/index.php?title=Isbogrel&action=edit&redlink=1" class="new" title="Isbogrel (page does not exist)">Isbogrel</a></li> <li><a href="/w/index.php?title=Midazogrel&action=edit&redlink=1" class="new" title="Midazogrel (page does not exist)">Midazogrel</a></li> <li><a href="/w/index.php?title=Nafagrel&action=edit&redlink=1" class="new" title="Nafagrel (page does not exist)">Nafagrel</a></li> <li><a href="/w/index.php?title=Nicogrelate&action=edit&redlink=1" class="new" title="Nicogrelate (page does not exist)">Nicogrelate</a></li> <li><a href="/wiki/Ozagrel" title="Ozagrel">Ozagrel</a></li> <li><a href="/wiki/Picotamide" title="Picotamide">Picotamide</a></li> <li><a href="/w/index.php?title=Pirmagrel&action=edit&redlink=1" class="new" title="Pirmagrel (page does not exist)">Pirmagrel</a></li> <li><a href="/w/index.php?title=Ridogrel&action=edit&redlink=1" class="new" title="Ridogrel (page does not exist)">Ridogrel</a></li> <li><a href="/w/index.php?title=Rolafagrel&action=edit&redlink=1" class="new" title="Rolafagrel (page does not exist)">Rolafagrel</a></li> <li><a href="/w/index.php?title=Samixogrel&action=edit&redlink=1" class="new" title="Samixogrel (page does not exist)">Samixogrel</a></li> <li><a href="/wiki/Terbogrel" title="Terbogrel">Terbogrel</a></li> <li><a href="/w/index.php?title=U63557A&action=edit&redlink=1" class="new" title="U63557A (page does not exist)">U63557A</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>Precursors:</b> <a href="/wiki/Linoleic_acid" title="Linoleic acid">Linoleic acid</a></li> <li><a href="/wiki/Gamma-Linolenic_acid" class="mw-redirect" title="Gamma-Linolenic acid">γ-Linolenic acid (gamolenic acid)</a></li> <li><a href="/wiki/Dihomo-%CE%B3-linolenic_acid" title="Dihomo-γ-linolenic acid">Dihomo-γ-linolenic acid</a></li> <li><a href="/wiki/Diglyceride" title="Diglyceride">Diacylglycerol</a></li> <li><a href="/wiki/Arachidonic_acid" title="Arachidonic acid">Arachidonic acid</a></li> <li><a href="/wiki/Prostaglandin_G2" 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