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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Allergic rhinitis</h1><div class="u-tcGrayDark">1,826 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Allergic rhinitis</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Allergic_rhinitis/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Allergic_rhinitis/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Allergic_rhinitis/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Allergic_rhinitis">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_77805407" data-work_id="77805407" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/77805407/Homeopathy_for_Allergic_Rhinitis_A_Systematic_Review">Homeopathy for Allergic Rhinitis: A Systematic Review</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of this study was to evaluate the efficacy and effectiveness of homeopathic intervention in the treatment of seasonal or perennial allergic rhinitis (AR). Randomized controlled trials evaluating all forms of homeopathic treatment... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_77805407" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of this study was to evaluate the efficacy and effectiveness of homeopathic intervention in the treatment of seasonal or perennial allergic rhinitis (AR). Randomized controlled trials evaluating all forms of homeopathic treatment for AR were included in a systematic review (SR) of studies published up to and including December 2015. Two authors independently screened potential studies, extracted data, and assessed risk of bias. Primary outcomes included symptom improvement and total quality-of-life score. Treatment effect size was quantified as mean difference (continuous data), or by risk ratio (RR) and odds ratio (dichotomous data), with 95% confidence intervals (CI). Meta-analysis was performed after assessing heterogeneity and risk of bias. Eleven studies were eligible for SR. All trials were placebo-controlled except one. Six trials used the treatment approach known as isopathy, but they were unsuitable for meta-analysis due to problems of heterogeneity and data extract...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/77805407" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="76d3f748115242897321a3bbe94bfccb" rel="nofollow" data-download="{"attachment_id":85070339,"asset_id":77805407,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85070339/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="3412352" href="https://leicester.academia.edu/JeremyHowick">Jeremy Howick</a><script data-card-contents-for-user="3412352" type="text/json">{"id":3412352,"first_name":"Jeremy","last_name":"Howick","domain_name":"leicester","page_name":"JeremyHowick","display_name":"Jeremy Howick","profile_url":"https://leicester.academia.edu/JeremyHowick?f_ri=87529","photo":"https://0.academia-photos.com/3412352/1169130/1465672/s65_jeremy.howick.jpg"}</script></span></span></li><li class="js-paper-rank-work_77805407 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="77805407"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 77805407, container: ".js-paper-rank-work_77805407", }); 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Six trials used the treatment approach known as isopathy, but they were unsuitable for meta-analysis due to problems of heterogeneity and data extract...","downloadable_attachments":[{"id":85070339,"asset_id":77805407,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":3412352,"first_name":"Jeremy","last_name":"Howick","domain_name":"leicester","page_name":"JeremyHowick","display_name":"Jeremy Howick","profile_url":"https://leicester.academia.edu/JeremyHowick?f_ri=87529","photo":"https://0.academia-photos.com/3412352/1169130/1465672/s65_jeremy.howick.jpg"}],"research_interests":[{"id":4083,"name":"Complementary and Alternative 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class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a><script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=53778272]'), work: {"id":53778272,"title":"Use of antihistamines in pediatrics","created_at":"2021-09-28T12:39:40.745-07:00","url":"https://www.academia.edu/53778272/Use_of_antihistamines_in_pediatrics?f_ri=87529","dom_id":"work_53778272","summary":null,"downloadable_attachments":[{"id":70460865,"asset_id":53778272,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39569493,"first_name":"Alfonso","last_name":"Del Cuvillo","domain_name":"independent","page_name":"AlfonsoDelCuvillo","display_name":"Alfonso Del 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href="https://cmu-tw.academia.edu/BingFangHwang">Bing-Fang Hwang</a><script data-card-contents-for-user="49414794" type="text/json">{"id":49414794,"first_name":"Bing-Fang","last_name":"Hwang","domain_name":"cmu-tw","page_name":"BingFangHwang","display_name":"Bing-Fang Hwang","profile_url":"https://cmu-tw.academia.edu/BingFangHwang?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_25716868 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25716868"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25716868, container: ".js-paper-rank-work_25716868", }); });</script></li><li class="js-percentile-work_25716868 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: 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{"id":25716868,"title":"Relation between air pollution and allergic rhinitis in Taiwananese schoolchildren","created_at":"2016-05-30T02:28:43.212-07:00","url":"https://www.academia.edu/25716868/Relation_between_air_pollution_and_allergic_rhinitis_in_Taiwananese_schoolchildren?f_ri=87529","dom_id":"work_25716868","summary":null,"downloadable_attachments":[{"id":46064174,"asset_id":25716868,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":49414794,"first_name":"Bing-Fang","last_name":"Hwang","domain_name":"cmu-tw","page_name":"BingFangHwang","display_name":"Bing-Fang Hwang","profile_url":"https://cmu-tw.academia.edu/BingFangHwang?f_ri=87529","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":11976,"name":"Air pollution","url":"https://www.academia.edu/Documents/in/Air_pollution?f_ri=87529","nofollow":false},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=87529","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=87529","nofollow":false},{"id":56132,"name":"Students","url":"https://www.academia.edu/Documents/in/Students?f_ri=87529","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529"},{"id":71905,"name":"Carbon Monoxide","url":"https://www.academia.edu/Documents/in/Carbon_Monoxide?f_ri=87529"},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529"},{"id":94451,"name":"Taiwan","url":"https://www.academia.edu/Documents/in/Taiwan?f_ri=87529"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=87529"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=87529"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=87529"},{"id":317051,"name":"School Children","url":"https://www.academia.edu/Documents/in/School_Children?f_ri=87529"},{"id":339532,"name":"Bayesian hierarchical model","url":"https://www.academia.edu/Documents/in/Bayesian_hierarchical_model?f_ri=87529"},{"id":380824,"name":"Ozone","url":"https://www.academia.edu/Documents/in/Ozone?f_ri=87529"},{"id":387921,"name":"Urban Air Pollution","url":"https://www.academia.edu/Documents/in/Urban_Air_Pollution?f_ri=87529"},{"id":400071,"name":"Respiratory","url":"https://www.academia.edu/Documents/in/Respiratory?f_ri=87529"},{"id":570668,"name":"Urban Population","url":"https://www.academia.edu/Documents/in/Urban_Population?f_ri=87529"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=87529"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=87529"},{"id":892171,"name":"Indoor Environment","url":"https://www.academia.edu/Documents/in/Indoor_Environment?f_ri=87529"},{"id":966020,"name":"Cross sectional Study","url":"https://www.academia.edu/Documents/in/Cross_sectional_Study?f_ri=87529"},{"id":1587858,"name":"Confidence Interval","url":"https://www.academia.edu/Documents/in/Confidence_Interval?f_ri=87529"},{"id":1656539,"name":"Air Pollutants","url":"https://www.academia.edu/Documents/in/Air_Pollutants?f_ri=87529"},{"id":2463496,"name":"Statistics as Topic","url":"https://www.academia.edu/Documents/in/Statistics_as_Topic?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_49395012" data-work_id="49395012" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 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data-download="{"attachment_id":67760402,"asset_id":49395012,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67760402/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="67783533" href="https://helsinki.academia.edu/ASovij%C3%A4rvi">A. Sovijärvi</a><script data-card-contents-for-user="67783533" type="text/json">{"id":67783533,"first_name":"A.","last_name":"Sovijärvi","domain_name":"helsinki","page_name":"ASovijärvi","display_name":"A. Sovijärvi","profile_url":"https://helsinki.academia.edu/ASovij%C3%A4rvi?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_49395012 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="49395012"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 49395012, container: ".js-paper-rank-work_49395012", }); });</script></li><li class="js-percentile-work_49395012 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 49395012; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_49395012"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_49395012 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="49395012"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 49395012; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=49395012]").text(description); $(".js-view-count-work_49395012").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_49395012").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="49395012"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="642" href="https://www.academia.edu/Documents/in/Respiratory_Medicine">Respiratory Medicine</a>, <script data-card-contents-for-ri="642" type="text/json">{"id":642,"name":"Respiratory Medicine","url":"https://www.academia.edu/Documents/in/Respiratory_Medicine?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1085" href="https://www.academia.edu/Documents/in/Epidemiology">Epidemiology</a>, <script data-card-contents-for-ri="1085" type="text/json">{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="46676" href="https://www.academia.edu/Documents/in/Finland">Finland</a><script data-card-contents-for-ri="46676" type="text/json">{"id":46676,"name":"Finland","url":"https://www.academia.edu/Documents/in/Finland?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=49395012]'), work: {"id":49395012,"title":"Allergic rhinoconjunctivitis doubles the risk for incident asthma – Results from a population study in Helsinki, Finland","created_at":"2021-06-26T06:55:55.068-07:00","url":"https://www.academia.edu/49395012/Allergic_rhinoconjunctivitis_doubles_the_risk_for_incident_asthma_Results_from_a_population_study_in_Helsinki_Finland?f_ri=87529","dom_id":"work_49395012","summary":null,"downloadable_attachments":[{"id":67760402,"asset_id":49395012,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":67783533,"first_name":"A.","last_name":"Sovijärvi","domain_name":"helsinki","page_name":"ASovijärvi","display_name":"A. Sovijärvi","profile_url":"https://helsinki.academia.edu/ASovij%C3%A4rvi?f_ri=87529","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":642,"name":"Respiratory Medicine","url":"https://www.academia.edu/Documents/in/Respiratory_Medicine?f_ri=87529","nofollow":false},{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=87529","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false},{"id":46676,"name":"Finland","url":"https://www.academia.edu/Documents/in/Finland?f_ri=87529","nofollow":false},{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=87529"},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=87529"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=87529"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=87529"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=87529"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=87529"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=87529"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=87529"},{"id":718203,"name":"Population Study","url":"https://www.academia.edu/Documents/in/Population_Study?f_ri=87529"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_50036794" data-work_id="50036794" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/50036794/Comorbidities_of_pediatric_asthma_A_narrative_review">Comorbidities of pediatric asthma: A narrative review</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Asthma is one of the most common persistent inflammatory respiratory disorders. Comorbidities are relatively common in asthma. The aim of this review study was to find comorbid disorders in children with asthma. Methods: For... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_50036794" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Asthma is one of the most common persistent inflammatory respiratory disorders. Comorbidities are relatively common in asthma. The aim of this review study was to find comorbid disorders in children with asthma. <br />Methods: For the purpose of this review, we searched databases including Scopus, Google scholar, PubMed, SID, Irandoc and up-to-date. Key words for the search included children asthma, comorbidity and pediatric asthma. There were no time limitations for the search. Full text articles in English language were included in this study. <br />Results: Neuropsychiatric comorbidities were Attention-deficit/hyperactivity disorder (ADHD) (11.5%), oppositional defiant disorder (ODD) (10.7%), separation anxiety disorder (6.1%), social anxiety disorder (3.8%), specific phobias (2.3%), agoraphobia without panic (1.5%), (mild) manic episodes (1.1%), major depressive episodes (MDE) (0.8%), movement (tic) disorder (0.8%) and dysthymia (0.4%). The prevalence of sinusitis was 13% in children with asthma (17). Prevalence of asthma in chronic rhinosinusitis with polyposis (CRSwP) is 26-48%, but the prevalence of CRSwP in asthmatic patients is only 7%. Asthma was prevalent in 25-35% patients with allergic rhinitis, and rhinitis symptoms were present in 75-90% of asthmatic patients. Asthma and obstructive sleep apnea (OSA) commonly coexist. Snoring (49.5%), gastro-esophageal reflux disease (GERD) (46.3%), atopic dermatitis (27.3%), allergic sinusitis (20%) and food allergy (10.5%) were common in children with asthma. <br />Conclusions: Our review has revealed that allergic rhinitis, gastroesophageal reflux, obesity, food allergy, obstructive sleep apnea, allergic conjunctivitis, chronic rhinosinusitis and psychological abnormalities are common comorbidities in children with asthma.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/50036794" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ef9a53981f5383283bf8d0d51608029e" rel="nofollow" data-download="{"attachment_id":68170365,"asset_id":50036794,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/68170365/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="111157745" href="https://mubabol.academia.edu/CaspianJournalofPediatrics">Caspian Journal of Pediatrics</a><script data-card-contents-for-user="111157745" type="text/json">{"id":111157745,"first_name":"Caspian Journal","last_name":"of Pediatrics","domain_name":"mubabol","page_name":"CaspianJournalofPediatrics","display_name":"Caspian Journal of Pediatrics","profile_url":"https://mubabol.academia.edu/CaspianJournalofPediatrics?f_ri=87529","photo":"https://0.academia-photos.com/111157745/26284612/24874269/s65_caspian_journal.of_pediatrics.jpg"}</script></span></span></li><li class="js-paper-rank-work_50036794 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="50036794"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 50036794, container: ".js-paper-rank-work_50036794", }); 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$(".js-view-count[data-work-id=50036794]").text(description); $(".js-view-count-work_50036794").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_50036794").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="50036794"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="54533" href="https://www.academia.edu/Documents/in/Children">Children</a>, <script data-card-contents-for-ri="54533" type="text/json">{"id":54533,"name":"Children","url":"https://www.academia.edu/Documents/in/Children?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a>, <script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1127068" href="https://www.academia.edu/Documents/in/Eczema">Eczema</a><script data-card-contents-for-ri="1127068" type="text/json">{"id":1127068,"name":"Eczema","url":"https://www.academia.edu/Documents/in/Eczema?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=50036794]'), work: {"id":50036794,"title":"Comorbidities of pediatric asthma: A narrative review","created_at":"2021-07-17T22:33:31.144-07:00","url":"https://www.academia.edu/50036794/Comorbidities_of_pediatric_asthma_A_narrative_review?f_ri=87529","dom_id":"work_50036794","summary":"Background: Asthma is one of the most common persistent inflammatory respiratory disorders. Comorbidities are relatively common in asthma. The aim of this review study was to find comorbid disorders in children with asthma.\r\nMethods: For the purpose of this review, we searched databases including Scopus, Google scholar, PubMed, SID, Irandoc and up-to-date. Key words for the search included children asthma, comorbidity and pediatric asthma. There were no time limitations for the search. Full text articles in English language were included in this study.\r\nResults: Neuropsychiatric comorbidities were Attention-deficit/hyperactivity disorder (ADHD) (11.5%), oppositional defiant disorder (ODD) (10.7%), separation anxiety disorder (6.1%), social anxiety disorder (3.8%), specific phobias (2.3%), agoraphobia without panic (1.5%), (mild) manic episodes (1.1%), major depressive episodes (MDE) (0.8%), movement (tic) disorder (0.8%) and dysthymia (0.4%). The prevalence of sinusitis was 13% in children with asthma (17). Prevalence of asthma in chronic rhinosinusitis with polyposis (CRSwP) is 26-48%, but the prevalence of CRSwP in asthmatic patients is only 7%. Asthma was prevalent in 25-35% patients with allergic rhinitis, and rhinitis symptoms were present in 75-90% of asthmatic patients. Asthma and obstructive sleep apnea (OSA) commonly coexist. Snoring (49.5%), gastro-esophageal reflux disease (GERD) (46.3%), atopic dermatitis (27.3%), allergic sinusitis (20%) and food allergy (10.5%) were common in children with asthma.\r\nConclusions: Our review has revealed that allergic rhinitis, gastroesophageal reflux, obesity, food allergy, obstructive sleep apnea, allergic conjunctivitis, chronic rhinosinusitis and psychological abnormalities are common comorbidities in children with asthma.","downloadable_attachments":[{"id":68170365,"asset_id":50036794,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":111157745,"first_name":"Caspian Journal","last_name":"of Pediatrics","domain_name":"mubabol","page_name":"CaspianJournalofPediatrics","display_name":"Caspian Journal of Pediatrics","profile_url":"https://mubabol.academia.edu/CaspianJournalofPediatrics?f_ri=87529","photo":"https://0.academia-photos.com/111157745/26284612/24874269/s65_caspian_journal.of_pediatrics.jpg"}],"research_interests":[{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false},{"id":54533,"name":"Children","url":"https://www.academia.edu/Documents/in/Children?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false},{"id":1127068,"name":"Eczema","url":"https://www.academia.edu/Documents/in/Eczema?f_ri=87529","nofollow":false},{"id":4045101,"name":"Comorbid","url":"https://www.academia.edu/Documents/in/Comorbid?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13392126" data-work_id="13392126" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13392126/Requirements_for_medications_commonly_used_in_the_treatment_of_allergic_rhinitis_European_Academy_of_Allergy_and_Clinical_Immunology_EAACI_Allergic_Rhinitis_and_its_Impact_on_Asthma_ARIA_">Requirements for medications commonly used in the treatment of allergic rhinitis. European Academy of Allergy and Clinical Immunology (EAACI) Allergic Rhinitis and its Impact on Asthma (ARIA)</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13392126" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="78266d92f925236ce4a4c2efe1dbaeae" rel="nofollow" data-download="{"attachment_id":45392777,"asset_id":13392126,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45392777/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32572573" href="https://aberdeen.academia.edu/DavidPrice">David Price</a><script data-card-contents-for-user="32572573" type="text/json">{"id":32572573,"first_name":"David","last_name":"Price","domain_name":"aberdeen","page_name":"DavidPrice","display_name":"David Price","profile_url":"https://aberdeen.academia.edu/DavidPrice?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13392126 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13392126"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13392126, container: ".js-paper-rank-work_13392126", }); 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$(".js-view-count[data-work-id=13392126]").text(description); $(".js-view-count-work_13392126").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13392126").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13392126"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="18520" href="https://www.academia.edu/Documents/in/Biological_Chemistry">Biological Chemistry</a>, <script data-card-contents-for-ri="18520" type="text/json">{"id":18520,"name":"Biological Chemistry","url":"https://www.academia.edu/Documents/in/Biological_Chemistry?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62896" href="https://www.academia.edu/Documents/in/Allergy">Allergy</a>, <script data-card-contents-for-ri="62896" type="text/json">{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a><script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13392126]'), work: {"id":13392126,"title":"Requirements for medications commonly used in the treatment of allergic rhinitis. European Academy of Allergy and Clinical Immunology (EAACI) Allergic Rhinitis and its Impact on Asthma (ARIA)","created_at":"2015-06-28T14:35:07.500-07:00","url":"https://www.academia.edu/13392126/Requirements_for_medications_commonly_used_in_the_treatment_of_allergic_rhinitis_European_Academy_of_Allergy_and_Clinical_Immunology_EAACI_Allergic_Rhinitis_and_its_Impact_on_Asthma_ARIA_?f_ri=87529","dom_id":"work_13392126","summary":null,"downloadable_attachments":[{"id":45392777,"asset_id":13392126,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32572573,"first_name":"David","last_name":"Price","domain_name":"aberdeen","page_name":"DavidPrice","display_name":"David Price","profile_url":"https://aberdeen.academia.edu/DavidPrice?f_ri=87529","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false},{"id":18520,"name":"Biological Chemistry","url":"https://www.academia.edu/Documents/in/Biological_Chemistry?f_ri=87529","nofollow":false},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false},{"id":204350,"name":"Anti-inflammatory agents","url":"https://www.academia.edu/Documents/in/Anti-inflammatory_agents?f_ri=87529"},{"id":833992,"name":"Intranasal Administration","url":"https://www.academia.edu/Documents/in/Intranasal_Administration?f_ri=87529"},{"id":1293308,"name":"Glucocorticoids","url":"https://www.academia.edu/Documents/in/Glucocorticoids?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_29204443" data-work_id="29204443" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div 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data-download="{"attachment_id":49655511,"asset_id":29204443,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49655511/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="55130564" href="https://independent.academia.edu/JanneHulkkonen">Janne Hulkkonen</a><script data-card-contents-for-user="55130564" type="text/json">{"id":55130564,"first_name":"Janne","last_name":"Hulkkonen","domain_name":"independent","page_name":"JanneHulkkonen","display_name":"Janne Hulkkonen","profile_url":"https://independent.academia.edu/JanneHulkkonen?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_29204443 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="29204443"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 29204443, container: ".js-paper-rank-work_29204443", }); });</script></li><li class="js-percentile-work_29204443 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 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class="clearfix u-pv7x u-mb0x js-work-card work_72511397" data-work_id="72511397" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/72511397/Population_Pharmacokinetic_Analysis_and_Optimization_of_the_Experimental_Design_for_Mizolastine_Solution_in_Children">Population Pharmacokinetic Analysis and Optimization of the Experimental Design for Mizolastine Solution in Children</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Mizolastine is a second generation antihistamine agent approved in Europe for the treatment of allergic rhinitis and skin conditions for which Sanofi~Synthélabo is developing a pediatric solution. Our objective was to design the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_72511397" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Mizolastine is a second generation antihistamine agent approved in Europe for the treatment of allergic rhinitis and skin conditions for which Sanofi~Synthélabo is developing a pediatric solution. Our objective was to design the population pharmacokinetic (PK) study of mizolastine pediatric solution in children. A bioavailability study of this solution compared to the marketed tablet was performed in 18 young volunteers. These PK data were analyzed by nonlinear regression using a two-compartment open model with zero-order absorption. From the estimated parameters, we designed population PK studies in two groups of children: 6 to 12 years and 2 to 6 years, respectively. To compare several population designs and to derive the optimal ones, we used the determinant of the Fisher information matrix of the population characteristics using a first-order expansion of the model. We have evaluated a “reference” population design with 10 samples (from 0.25 to 36 hr after drug intake) per child...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/72511397" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0d380ea732cade7824eec29ccd8839bf" rel="nofollow" data-download="{"attachment_id":81410192,"asset_id":72511397,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81410192/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="97787799" href="https://independent.academia.edu/CDUBRUC">Catherine DUBRUC</a><script data-card-contents-for-user="97787799" type="text/json">{"id":97787799,"first_name":"Catherine","last_name":"DUBRUC","domain_name":"independent","page_name":"CDUBRUC","display_name":"Catherine DUBRUC","profile_url":"https://independent.academia.edu/CDUBRUC?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_72511397 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="72511397"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 72511397, container: ".js-paper-rank-work_72511397", }); 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$(".js-view-count[data-work-id=72511397]").text(description); $(".js-view-count-work_72511397").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_72511397").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="72511397"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2066" href="https://www.academia.edu/Documents/in/Research_Design">Research Design</a>, <script data-card-contents-for-ri="2066" type="text/json">{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5493" href="https://www.academia.edu/Documents/in/Nonlinear_dynamics">Nonlinear dynamics</a>, <script data-card-contents-for-ri="5493" type="text/json">{"id":5493,"name":"Nonlinear dynamics","url":"https://www.academia.edu/Documents/in/Nonlinear_dynamics?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" href="https://www.academia.edu/Documents/in/Child">Child</a>, <script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="86410" href="https://www.academia.edu/Documents/in/Nonlinear_Regression">Nonlinear Regression</a><script data-card-contents-for-ri="86410" type="text/json">{"id":86410,"name":"Nonlinear Regression","url":"https://www.academia.edu/Documents/in/Nonlinear_Regression?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=72511397]'), work: {"id":72511397,"title":"Population Pharmacokinetic Analysis and Optimization of the Experimental Design for Mizolastine Solution in Children","created_at":"2022-02-26T11:55:49.831-08:00","url":"https://www.academia.edu/72511397/Population_Pharmacokinetic_Analysis_and_Optimization_of_the_Experimental_Design_for_Mizolastine_Solution_in_Children?f_ri=87529","dom_id":"work_72511397","summary":"Mizolastine is a second generation antihistamine agent approved in Europe for the treatment of allergic rhinitis and skin conditions for which Sanofi~Synthélabo is developing a pediatric solution. Our objective was to design the population pharmacokinetic (PK) study of mizolastine pediatric solution in children. A bioavailability study of this solution compared to the marketed tablet was performed in 18 young volunteers. These PK data were analyzed by nonlinear regression using a two-compartment open model with zero-order absorption. From the estimated parameters, we designed population PK studies in two groups of children: 6 to 12 years and 2 to 6 years, respectively. To compare several population designs and to derive the optimal ones, we used the determinant of the Fisher information matrix of the population characteristics using a first-order expansion of the model. We have evaluated a “reference” population design with 10 samples (from 0.25 to 36 hr after drug intake) per child...","downloadable_attachments":[{"id":81410192,"asset_id":72511397,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":97787799,"first_name":"Catherine","last_name":"DUBRUC","domain_name":"independent","page_name":"CDUBRUC","display_name":"Catherine DUBRUC","profile_url":"https://independent.academia.edu/CDUBRUC?f_ri=87529","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=87529","nofollow":false},{"id":5493,"name":"Nonlinear dynamics","url":"https://www.academia.edu/Documents/in/Nonlinear_dynamics?f_ri=87529","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529","nofollow":false},{"id":86410,"name":"Nonlinear Regression","url":"https://www.academia.edu/Documents/in/Nonlinear_Regression?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529"},{"id":414692,"name":"Solutions","url":"https://www.academia.edu/Documents/in/Solutions?f_ri=87529"},{"id":801413,"name":"Benzimidazoles","url":"https://www.academia.edu/Documents/in/Benzimidazoles?f_ri=87529"},{"id":1141485,"name":"Area Under the Curve","url":"https://www.academia.edu/Documents/in/Area_Under_the_Curve?f_ri=87529"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=87529"},{"id":2937490,"name":"Fisher Information Matrix ","url":"https://www.academia.edu/Documents/in/Fisher_Information_Matrix?f_ri=87529"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18010430" data-work_id="18010430" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18010430/Allergic_rhinitis_and_asthma_comorbidity_ARIA_classification_of_rhinitis_does_not_correlate_with_the_prevalence_of_asthma">Allergic rhinitis and asthma comorbidity: ARIA classification of rhinitis does not correlate with the prevalence of asthma</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Allergic rhinitis and asthma comorbidity is supported by both the similar underlying pathogenesis and immunologic mechanisms. The aim of this study was to verify whether the characteristics of rhinitis classified according to the new... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18010430" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Allergic rhinitis and asthma comorbidity is supported by both the similar underlying pathogenesis and immunologic mechanisms. The aim of this study was to verify whether the characteristics of rhinitis classified according to the new Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines correlate with the prevalence of asthma. From 1 March to 30 June 2002, a multi-centre cross-sectional study was conducted by 154 allergists chosen from throughout Italy. Duration, severity of rhinitis (according to the ARIA classification) and the type of allergic sensitizations were compared with the prevalence of asthma. One thousand three hundred and twenty-one consecutive rhinitis-allergic patients aged 18 years or older were enrolled for the study. The majority of patients, 1060 (80.24%), were on medication at the time of their specialist visit. Mild intermittent rhinitis was diagnosed in 7.7% of patients, moderate/severe intermittent in 17.1%, mild persistent in 11.6%, and moderate/severe persistent in 63.6%. The prevalence of asthma was 48% in patients with mild intermittent rhinitis, 49.6% in moderate-severe intermittent rhinitis, 36.6% in mild persistent rhinitis and 47.5% in moderate severe persistent patients. No correlation between the ARIA categories of rhinitis and the prevalence of asthma was found. A multivariate analysis, after adjustment for age, sex, type of sensitization, level of severity and duration of rhinitis classified according to the ARIA guidelines, demonstrated that age, over 41 years [risk ratio (RR) 1.260, 95% confidence interval (CI) 1.072-1.482] and especially over 51 years (RR 1.460, 95% CI 1.237-1.723), sensitization to indoor allergens (mite and cat), (RR 1.203, 95% CI 1.060-1.366), and polysensitization (RR 1.178, 95% CI 1.004-1.383) are significant risk factors for asthma. In allergic rhinitis (AR) patients referred to a specialist, the features of AR as defined by the ARIA classification are not able to predict the presence of asthma, therefore all such patients should be assessed for asthma.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18010430" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="196533752893c4543efa6fcf8c10a05c" rel="nofollow" data-download="{"attachment_id":42206733,"asset_id":18010430,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42206733/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37941771" href="https://independent.academia.edu/SusannaVoltolini">Susanna Voltolini</a><script data-card-contents-for-user="37941771" type="text/json">{"id":37941771,"first_name":"Susanna","last_name":"Voltolini","domain_name":"independent","page_name":"SusannaVoltolini","display_name":"Susanna Voltolini","profile_url":"https://independent.academia.edu/SusannaVoltolini?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18010430 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18010430"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18010430, container: ".js-paper-rank-work_18010430", }); 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$(".js-view-count[data-work-id=18010430]").text(description); $(".js-view-count-work_18010430").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18010430").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18010430"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="28973" href="https://www.academia.edu/Documents/in/Comorbidity">Comorbidity</a><script data-card-contents-for-ri="28973" type="text/json">{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18010430]'), work: {"id":18010430,"title":"Allergic rhinitis and asthma comorbidity: ARIA classification of rhinitis does not correlate with the prevalence of asthma","created_at":"2015-11-09T04:41:36.865-08:00","url":"https://www.academia.edu/18010430/Allergic_rhinitis_and_asthma_comorbidity_ARIA_classification_of_rhinitis_does_not_correlate_with_the_prevalence_of_asthma?f_ri=87529","dom_id":"work_18010430","summary":"Allergic rhinitis and asthma comorbidity is supported by both the similar underlying pathogenesis and immunologic mechanisms. The aim of this study was to verify whether the characteristics of rhinitis classified according to the new Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines correlate with the prevalence of asthma. From 1 March to 30 June 2002, a multi-centre cross-sectional study was conducted by 154 allergists chosen from throughout Italy. Duration, severity of rhinitis (according to the ARIA classification) and the type of allergic sensitizations were compared with the prevalence of asthma. One thousand three hundred and twenty-one consecutive rhinitis-allergic patients aged 18 years or older were enrolled for the study. The majority of patients, 1060 (80.24%), were on medication at the time of their specialist visit. Mild intermittent rhinitis was diagnosed in 7.7% of patients, moderate/severe intermittent in 17.1%, mild persistent in 11.6%, and moderate/severe persistent in 63.6%. The prevalence of asthma was 48% in patients with mild intermittent rhinitis, 49.6% in moderate-severe intermittent rhinitis, 36.6% in mild persistent rhinitis and 47.5% in moderate severe persistent patients. No correlation between the ARIA categories of rhinitis and the prevalence of asthma was found. A multivariate analysis, after adjustment for age, sex, type of sensitization, level of severity and duration of rhinitis classified according to the ARIA guidelines, demonstrated that age, over 41 years [risk ratio (RR) 1.260, 95% confidence interval (CI) 1.072-1.482] and especially over 51 years (RR 1.460, 95% CI 1.237-1.723), sensitization to indoor allergens (mite and cat), (RR 1.203, 95% CI 1.060-1.366), and polysensitization (RR 1.178, 95% CI 1.004-1.383) are significant risk factors for asthma. In allergic rhinitis (AR) patients referred to a specialist, the features of AR as defined by the ARIA classification are not able to predict the presence of asthma, therefore all such patients should be assessed for asthma.","downloadable_attachments":[{"id":42206733,"asset_id":18010430,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37941771,"first_name":"Susanna","last_name":"Voltolini","domain_name":"independent","page_name":"SusannaVoltolini","display_name":"Susanna Voltolini","profile_url":"https://independent.academia.edu/SusannaVoltolini?f_ri=87529","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=87529","nofollow":false},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=87529","nofollow":false},{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=87529"},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=87529"},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529"},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=87529"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=87529"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=87529"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=87529"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=87529"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=87529"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=87529"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=87529"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=87529"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18069612 coauthored" data-work_id="18069612" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18069612/RhinAsthma_Patient_Perspective_a_short_daily_asthma_and_rhinitis_QoL_assessment">RhinAsthma Patient Perspective: a short daily asthma and rhinitis QoL assessment</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18069612" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="da03079df3c878bf9720890ad6b6dbed" rel="nofollow" data-download="{"attachment_id":39859462,"asset_id":18069612,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39859462/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38016153" href="https://independent.academia.edu/OlivieroRossi">Oliviero Rossi</a><script data-card-contents-for-user="38016153" type="text/json">{"id":38016153,"first_name":"Oliviero","last_name":"Rossi","domain_name":"independent","page_name":"OlivieroRossi","display_name":"Oliviero Rossi","profile_url":"https://independent.academia.edu/OlivieroRossi?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-18069612">+1</span><div class="hidden js-additional-users-18069612"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/GGirbino">G. Girbino</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-18069612'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-18069612').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_18069612 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18069612"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18069612, container: ".js-paper-rank-work_18069612", }); });</script></li><li class="js-percentile-work_18069612 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 18069612; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_18069612"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_18069612 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="18069612"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 18069612; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=18069612]").text(description); $(".js-view-count-work_18069612").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18069612").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18069612"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2599" href="https://www.academia.edu/Documents/in/Psychometrics">Psychometrics</a>, <script data-card-contents-for-ri="2599" type="text/json">{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7470" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a><script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18069612]'), work: {"id":18069612,"title":"RhinAsthma Patient Perspective: a short daily asthma and rhinitis QoL assessment","created_at":"2015-11-10T02:25:36.664-08:00","url":"https://www.academia.edu/18069612/RhinAsthma_Patient_Perspective_a_short_daily_asthma_and_rhinitis_QoL_assessment?f_ri=87529","dom_id":"work_18069612","summary":null,"downloadable_attachments":[{"id":39859462,"asset_id":18069612,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38016153,"first_name":"Oliviero","last_name":"Rossi","domain_name":"independent","page_name":"OlivieroRossi","display_name":"Oliviero Rossi","profile_url":"https://independent.academia.edu/OlivieroRossi?f_ri=87529","photo":"/images/s65_no_pic.png"},{"id":38121038,"first_name":"G.","last_name":"Girbino","domain_name":"independent","page_name":"GGirbino","display_name":"G. 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Symptoms often impair sleep, resulting in tiredness and poor concentration. Children with seasonal AR... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24023180" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Acute and chronic symptoms of allergic rhinitis (AR) can disrupt school and leisure activities, significantly reducing quality of life. Symptoms often impair sleep, resulting in tiredness and poor concentration. Children with seasonal AR perform significantly worse in summer exams, relative to their mock exam results, when compared with their peers. Those individuals showing most symptoms are also likely to be affected by other allergic diseases, magnifying the detrimental impact on quality of life. Nasal blockage is the most common complaint associated with chronic AR, with acute exacerbations causing sneezing, clear nasal discharge and itchy eyes following exposure to the relevant airborne triggers. Allergen avoidance measures should be instituted according to seasonal or perennial symptomatology guided by allergy testing, alongside nonsedating antihistamines such as cetirizine or loratadine. Continued symptoms should be treated with regular intranasal steroid spray. Anti-leukotri...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24023180" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="719fc9b67ac2b947a27acfd2f74c03ae" rel="nofollow" data-download="{"attachment_id":44400952,"asset_id":24023180,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44400952/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46374782" href="https://independent.academia.edu/TomMarrs">Tom Marrs</a><script data-card-contents-for-user="46374782" type="text/json">{"id":46374782,"first_name":"Tom","last_name":"Marrs","domain_name":"independent","page_name":"TomMarrs","display_name":"Tom Marrs","profile_url":"https://independent.academia.edu/TomMarrs?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24023180 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24023180"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24023180, container: ".js-paper-rank-work_24023180", }); 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Symptoms often impair sleep, resulting in tiredness and poor concentration. Children with seasonal AR perform significantly worse in summer exams, relative to their mock exam results, when compared with their peers. Those individuals showing most symptoms are also likely to be affected by other allergic diseases, magnifying the detrimental impact on quality of life. Nasal blockage is the most common complaint associated with chronic AR, with acute exacerbations causing sneezing, clear nasal discharge and itchy eyes following exposure to the relevant airborne triggers. Allergen avoidance measures should be instituted according to seasonal or perennial symptomatology guided by allergy testing, alongside nonsedating antihistamines such as cetirizine or loratadine. Continued symptoms should be treated with regular intranasal steroid spray. 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The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23516121" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9e8b51b8b5283f9d43de524e7c987e59" rel="nofollow" data-download="{"attachment_id":43951809,"asset_id":23516121,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43951809/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="45528898" href="https://independent.academia.edu/CarstenBindslevjensen">Carsten Bindslev-jensen</a><script data-card-contents-for-user="45528898" type="text/json">{"id":45528898,"first_name":"Carsten","last_name":"Bindslev-jensen","domain_name":"independent","page_name":"CarstenBindslevjensen","display_name":"Carsten Bindslev-jensen","profile_url":"https://independent.academia.edu/CarstenBindslevjensen?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_23516121 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23516121"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23516121, container: ".js-paper-rank-work_23516121", }); 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$(".js-view-count[data-work-id=23516121]").text(description); $(".js-view-count-work_23516121").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_23516121").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="23516121"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1085" href="https://www.academia.edu/Documents/in/Epidemiology">Epidemiology</a>, <script data-card-contents-for-ri="1085" type="text/json">{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7324" href="https://www.academia.edu/Documents/in/British">British</a>, <script data-card-contents-for-ri="7324" type="text/json">{"id":7324,"name":"British","url":"https://www.academia.edu/Documents/in/British?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23516121]'), work: {"id":23516121,"title":"Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis","created_at":"2016-03-21T07:08:19.283-07:00","url":"https://www.academia.edu/23516121/Prevalence_of_atopic_dermatitis_asthma_allergic_rhinitis_and_hand_and_contact_dermatitis_in_adolescents_The_Odense_Adolescence_Cohort_Study_on_Atopic_Diseases_and_Dermatitis?f_ri=87529","dom_id":"work_23516121","summary":null,"downloadable_attachments":[{"id":43951809,"asset_id":23516121,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":45528898,"first_name":"Carsten","last_name":"Bindslev-jensen","domain_name":"independent","page_name":"CarstenBindslevjensen","display_name":"Carsten Bindslev-jensen","profile_url":"https://independent.academia.edu/CarstenBindslevjensen?f_ri=87529","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=87529","nofollow":false},{"id":7324,"name":"British","url":"https://www.academia.edu/Documents/in/British?f_ri=87529","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=87529","nofollow":false},{"id":54085,"name":"Denmark","url":"https://www.academia.edu/Documents/in/Denmark?f_ri=87529"},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=87529"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529"},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529"},{"id":131185,"name":"Cohort Study","url":"https://www.academia.edu/Documents/in/Cohort_Study?f_ri=87529"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=87529"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=87529"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=87529"},{"id":379038,"name":"Contact Dermatitis","url":"https://www.academia.edu/Documents/in/Contact_Dermatitis?f_ri=87529"},{"id":591601,"name":"Atopic Dermatitis","url":"https://www.academia.edu/Documents/in/Atopic_Dermatitis?f_ri=87529"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=87529"},{"id":1171968,"name":"Patch Tests","url":"https://www.academia.edu/Documents/in/Patch_Tests?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_44738392" data-work_id="44738392" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/44738392/Comparative_study_of_the_effect_of_bilastine_and_cetirizine_on_cognitive_functions_at_ground_level_and_at_an_altitude_of_4_000_m_simulated_in_hypobaric_chamber_a_randomized_double_blind_placebo_controlled_cross_over_study">Comparative study of the effect of bilastine and cetirizine on cognitive functions at ground level and at an altitude of 4,000 m simulated in hypobaric chamber: a randomized, double-blind, placebo-controlled, cross-over study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Introduction: Antihistamines are easily accessible and cover the vast majority of the medical therapy of allergic rhinitis. However, their systemic administration may more frequently associate with their wellknown side-effect, sedation,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_44738392" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Introduction: Antihistamines are easily accessible and cover the vast majority of the medical therapy of<br />allergic rhinitis. However, their systemic administration may more frequently associate with their wellknown side-effect, sedation, which is a serious problem in persons in safety-critical jobs such as aviation.<br />We have a poor understanding whether a non-sedative antihistamine has an impact on vigilance when<br />hypobaric hypoxia occurs during flight.<br />Methods: In this randomized, placebo-controlled, double-blind, cross-over study the effect of 20 mg<br />bilastine was compared to 10mg cetirizine and to placebo (20mg pyridoxine) in 33 individuals at ground<br />level and at 4,000 m altitude simulated in hypobaric chamber. Levels of vigilance, ultrashort memory,<br />combined distributive attention, monotony tolerance and peripheral blood oxygen saturation (SpO2)<br />were assessed.<br />Results: Bilastine did not impair the tested abilities in comparison with the control groups either at<br />ground level or hypobaric hypoxia. Administration of cetirizine increased the number of errors at ground<br />level. At the simulated altitude, already impaired results were additionally demonstrated with regards to<br />the distributive attention test.<br />Conclusions: From the two examined antihistamines, bilastine should be the preferred medication for by<br />individuals who require constant attention and are exposed to hypobaric hypoxia.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/44738392" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="de1c41044350d7d3136085dad7481ef1" rel="nofollow" data-download="{"attachment_id":65224098,"asset_id":44738392,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/65224098/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="181640714" href="https://sote.academia.edu/D%C3%A1vidMoln%C3%A1r">Dávid Molnár</a><script data-card-contents-for-user="181640714" type="text/json">{"id":181640714,"first_name":"Dávid","last_name":"Molnár","domain_name":"sote","page_name":"DávidMolnár","display_name":"Dávid Molnár","profile_url":"https://sote.academia.edu/D%C3%A1vidMoln%C3%A1r?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_44738392 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="44738392"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 44738392, container: ".js-paper-rank-work_44738392", }); 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$(".js-view-count[data-work-id=44738392]").text(description); $(".js-view-count-work_44738392").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_44738392").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="44738392"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="572" href="https://www.academia.edu/Documents/in/Military_Medicine">Military Medicine</a>, <script data-card-contents-for-ri="572" type="text/json">{"id":572,"name":"Military Medicine","url":"https://www.academia.edu/Documents/in/Military_Medicine?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a>, <script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="413155" href="https://www.academia.edu/Documents/in/Drug_Safety">Drug Safety</a>, <script data-card-contents-for-ri="413155" type="text/json">{"id":413155,"name":"Drug Safety","url":"https://www.academia.edu/Documents/in/Drug_Safety?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1279082" href="https://www.academia.edu/Documents/in/Antihistamines">Antihistamines</a><script data-card-contents-for-ri="1279082" type="text/json">{"id":1279082,"name":"Antihistamines","url":"https://www.academia.edu/Documents/in/Antihistamines?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=44738392]'), work: {"id":44738392,"title":"Comparative study of the effect of bilastine and cetirizine on cognitive functions at ground level and at an altitude of 4,000 m simulated in hypobaric chamber: a randomized, double-blind, placebo-controlled, cross-over study","created_at":"2020-12-19T07:37:47.611-08:00","url":"https://www.academia.edu/44738392/Comparative_study_of_the_effect_of_bilastine_and_cetirizine_on_cognitive_functions_at_ground_level_and_at_an_altitude_of_4_000_m_simulated_in_hypobaric_chamber_a_randomized_double_blind_placebo_controlled_cross_over_study?f_ri=87529","dom_id":"work_44738392","summary":"Introduction: Antihistamines are easily accessible and cover the vast majority of the medical therapy of\nallergic rhinitis. However, their systemic administration may more frequently associate with their wellknown side-effect, sedation, which is a serious problem in persons in safety-critical jobs such as aviation.\nWe have a poor understanding whether a non-sedative antihistamine has an impact on vigilance when\nhypobaric hypoxia occurs during flight.\nMethods: In this randomized, placebo-controlled, double-blind, cross-over study the effect of 20 mg\nbilastine was compared to 10mg cetirizine and to placebo (20mg pyridoxine) in 33 individuals at ground\nlevel and at 4,000 m altitude simulated in hypobaric chamber. Levels of vigilance, ultrashort memory,\ncombined distributive attention, monotony tolerance and peripheral blood oxygen saturation (SpO2)\nwere assessed.\nResults: Bilastine did not impair the tested abilities in comparison with the control groups either at\nground level or hypobaric hypoxia. Administration of cetirizine increased the number of errors at ground\nlevel. At the simulated altitude, already impaired results were additionally demonstrated with regards to\nthe distributive attention test.\nConclusions: From the two examined antihistamines, bilastine should be the preferred medication for by\nindividuals who require constant attention and are exposed to hypobaric hypoxia. ","downloadable_attachments":[{"id":65224098,"asset_id":44738392,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":181640714,"first_name":"Dávid","last_name":"Molnár","domain_name":"sote","page_name":"DávidMolnár","display_name":"Dávid Molnár","profile_url":"https://sote.academia.edu/D%C3%A1vidMoln%C3%A1r?f_ri=87529","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":572,"name":"Military Medicine","url":"https://www.academia.edu/Documents/in/Military_Medicine?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false},{"id":413155,"name":"Drug Safety","url":"https://www.academia.edu/Documents/in/Drug_Safety?f_ri=87529","nofollow":false},{"id":1279082,"name":"Antihistamines","url":"https://www.academia.edu/Documents/in/Antihistamines?f_ri=87529","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 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href="https://independent.academia.edu/dipakranjannayak">dipak ranjan nayak</a><script data-card-contents-for-user="35754734" type="text/json">{"id":35754734,"first_name":"dipak ranjan","last_name":"nayak","domain_name":"independent","page_name":"dipakranjannayak","display_name":"dipak ranjan nayak","profile_url":"https://independent.academia.edu/dipakranjannayak?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_61855203 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61855203"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61855203, container: ".js-paper-rank-work_61855203", }); });</script></li><li class="js-percentile-work_61855203 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x 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septum","url":"https://www.academia.edu/Documents/in/Nasal_septum?f_ri=87529"},{"id":3192547,"name":"Nasal Polyps","url":"https://www.academia.edu/Documents/in/Nasal_Polyps?f_ri=87529"},{"id":3870542,"name":"Ethmoid Sinus","url":"https://www.academia.edu/Documents/in/Ethmoid_Sinus?f_ri=87529"},{"id":3870543,"name":"Ethmoid Sinusitis","url":"https://www.academia.edu/Documents/in/Ethmoid_Sinusitis?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22016148" data-work_id="22016148" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22016148/Randomised_controlled_trial_of_homoeopathy_versus_placebo_in_perennial_allergic_rhinitis_with_overview_of_four_trial_series">Randomised controlled trial of homoeopathy versus placebo in perennial allergic rhinitis with overview of four trial series</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To test the hypothesis that homoeopathy is a placebo by examining its effect in patients with allergic rhinitis and so contest the evidence from three previous trials in this series. Randomised, double blind, placebo controlled, parallel... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22016148" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To test the hypothesis that homoeopathy is a placebo by examining its effect in patients with allergic rhinitis and so contest the evidence from three previous trials in this series. Randomised, double blind, placebo controlled, parallel group, multicentre study. Four general practices and a hospital ear, nose, and throat outpatient department. 51 patients with perennial allergic rhinitis. Random assignment to an oral 30c homoeopathic preparation of principal inhalant allergen or to placebo. Changes from baseline in nasal inspiratory peak flow and symptom visual analogue scale score over third and fourth weeks after randomisation. Fifty patients completed the study. The homoeopathy group had a significant objective improvement in nasal airflow compared with the placebo group (mean difference 19.8 l/min, 95% confidence interval 10.4 to 29.1, P=0.0001). Both groups reported improvement in symptoms, with patients taking homoeopathy reporting more improvement in all but one of the centr...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22016148" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="04e89dd7aeb785b6d9e012d3c751da0b" rel="nofollow" data-download="{"attachment_id":42712265,"asset_id":22016148,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42712265/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43280717" href="https://glasgow.academia.edu/DavidReilly">David Reilly</a><script data-card-contents-for-user="43280717" type="text/json">{"id":43280717,"first_name":"David","last_name":"Reilly","domain_name":"glasgow","page_name":"DavidReilly","display_name":"David Reilly","profile_url":"https://glasgow.academia.edu/DavidReilly?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22016148 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22016148"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22016148, container: ".js-paper-rank-work_22016148", }); 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Randomised, double blind, placebo controlled, parallel group, multicentre study. Four general practices and a hospital ear, nose, and throat outpatient department. 51 patients with perennial allergic rhinitis. Random assignment to an oral 30c homoeopathic preparation of principal inhalant allergen or to placebo. Changes from baseline in nasal inspiratory peak flow and symptom visual analogue scale score over third and fourth weeks after randomisation. Fifty patients completed the study. The homoeopathy group had a significant objective improvement in nasal airflow compared with the placebo group (mean difference 19.8 l/min, 95% confidence interval 10.4 to 29.1, P=0.0001). Both groups reported improvement in symptoms, with patients taking homoeopathy reporting more improvement in all but one of the centr...","downloadable_attachments":[{"id":42712265,"asset_id":22016148,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43280717,"first_name":"David","last_name":"Reilly","domain_name":"glasgow","page_name":"DavidReilly","display_name":"David Reilly","profile_url":"https://glasgow.academia.edu/DavidReilly?f_ri=87529","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":634,"name":"General Practice","url":"https://www.academia.edu/Documents/in/General_Practice?f_ri=87529","nofollow":false},{"id":4085,"name":"Homeopathy","url":"https://www.academia.edu/Documents/in/Homeopathy?f_ri=87529","nofollow":false},{"id":12426,"name":"Treatment 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Trial","url":"https://www.academia.edu/Documents/in/Randomised_Controlled_Trial?f_ri=87529"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=87529"},{"id":475235,"name":"BMJ","url":"https://www.academia.edu/Documents/in/BMJ?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_12669879" data-work_id="12669879" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12669879/Allergic_rhinitis_management_pocket_reference_2008">Allergic rhinitis management pocket reference 2008</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button 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u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="31670302" href="https://independent.academia.edu/JeanBousquet">Jean Bousquet</a><script data-card-contents-for-user="31670302" type="text/json">{"id":31670302,"first_name":"Jean","last_name":"Bousquet","domain_name":"independent","page_name":"JeanBousquet","display_name":"Jean Bousquet","profile_url":"https://independent.academia.edu/JeanBousquet?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_12669879 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="12669879"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 12669879, container: 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Care","url":"https://www.academia.edu/Documents/in/Primary_Care?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3645" href="https://www.academia.edu/Documents/in/Evidence_Based_Medicine">Evidence Based Medicine</a>, <script data-card-contents-for-ri="3645" type="text/json">{"id":3645,"name":"Evidence Based Medicine","url":"https://www.academia.edu/Documents/in/Evidence_Based_Medicine?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3709" href="https://www.academia.edu/Documents/in/Evidence_Based_Practice">Evidence Based Practice</a><script data-card-contents-for-ri="3709" 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Index","url":"https://www.academia.edu/Documents/in/Severity_of_Illness_Index?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14349602" data-work_id="14349602" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14349602/Clinical_practice_guideline_allergic_rhinitis">Clinical practice guideline: allergic rhinitis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Allergic rhinitis (AR) is one of the most common diseases affecting adults. It is the most common chronic disease in children in the United States today and the fifth most common chronic disease in the United States overall. AR is... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14349602" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Allergic rhinitis (AR) is one of the most common diseases affecting adults. It is the most common chronic disease in children in the United States today and the fifth most common chronic disease in the United States overall. AR is estimated to affect nearly 1 in every 6 Americans and generates $2 to $5 billion in direct health expenditures annually. It can impair quality of life and, through loss of work and school attendance, is responsible for as much as $2 to $4 billion in lost productivity annually. Not surprisingly, myriad diagnostic tests and treatments are used in managing this disorder, yet there is considerable variation in their use. This clinical practice guideline was undertaken to optimize the care of patients with AR by addressing quality improvement opportunities through an evaluation of the available evidence and an assessment of the harm-benefit balance of various diagnostic and management options. 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It is the most common chronic disease in children in the United States today and the fifth most common chronic disease in the United States overall. AR is estimated to affect nearly 1 in every 6 Americans and generates $2 to $5 billion in direct health expenditures annually. It can impair quality of life and, through loss of work and school attendance, is responsible for as much as $2 to $4 billion in lost productivity annually. Not surprisingly, myriad diagnostic tests and treatments are used in managing this disorder, yet there is considerable variation in their use. This clinical practice guideline was undertaken to optimize the care of patients with AR by addressing quality improvement opportunities through an evaluation of the available evidence and an assessment of the harm-benefit balance of various diagnostic and management options. 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class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="28783606" href="https://independent.academia.edu/DanielTruong3">Daniel Truong</a><script data-card-contents-for-user="28783606" type="text/json">{"id":28783606,"first_name":"Daniel","last_name":"Truong","domain_name":"independent","page_name":"DanielTruong3","display_name":"Daniel Truong","profile_url":"https://independent.academia.edu/DanielTruong3?f_ri=87529","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_11732228 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11732228"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11732228, container: ".js-paper-rank-work_11732228", }); });</script></li><li 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var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11732228]").text(description); $(".js-view-count-work_11732228").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11732228").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11732228"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3645" href="https://www.academia.edu/Documents/in/Evidence_Based_Medicine">Evidence Based Medicine</a>, <script data-card-contents-for-ri="3645" type="text/json">{"id":3645,"name":"Evidence Based Medicine","url":"https://www.academia.edu/Documents/in/Evidence_Based_Medicine?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3709" href="https://www.academia.edu/Documents/in/Evidence_Based_Practice">Evidence Based Practice</a>, <script data-card-contents-for-ri="3709" type="text/json">{"id":3709,"name":"Evidence Based Practice","url":"https://www.academia.edu/Documents/in/Evidence_Based_Practice?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="11636" href="https://www.academia.edu/Documents/in/Face">Face</a>, <script data-card-contents-for-ri="11636" type="text/json">{"id":11636,"name":"Face","url":"https://www.academia.edu/Documents/in/Face?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a><script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11732228]'), work: {"id":11732228,"title":"Evidence-based review and assessment of botulinum neurotoxin for the treatment of movement disorders","created_at":"2015-03-30T23:29:53.037-07:00","url":"https://www.academia.edu/11732228/Evidence_based_review_and_assessment_of_botulinum_neurotoxin_for_the_treatment_of_movement_disorders?f_ri=87529","dom_id":"work_11732228","summary":null,"downloadable_attachments":[{"id":46554656,"asset_id":11732228,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":28783606,"first_name":"Daniel","last_name":"Truong","domain_name":"independent","page_name":"DanielTruong3","display_name":"Daniel Truong","profile_url":"https://independent.academia.edu/DanielTruong3?f_ri=87529","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3645,"name":"Evidence Based Medicine","url":"https://www.academia.edu/Documents/in/Evidence_Based_Medicine?f_ri=87529","nofollow":false},{"id":3709,"name":"Evidence Based Practice","url":"https://www.academia.edu/Documents/in/Evidence_Based_Practice?f_ri=87529","nofollow":false},{"id":11636,"name":"Face","url":"https://www.academia.edu/Documents/in/Face?f_ri=87529","nofollow":false},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=87529","nofollow":false},{"id":43367,"name":"Movement disorders","url":"https://www.academia.edu/Documents/in/Movement_disorders?f_ri=87529"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529"},{"id":84269,"name":"Hyperhidrosis","url":"https://www.academia.edu/Documents/in/Hyperhidrosis?f_ri=87529"},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529"},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=87529"},{"id":168147,"name":"Tremor","url":"https://www.academia.edu/Documents/in/Tremor?f_ri=87529"},{"id":209780,"name":"Dystonia","url":"https://www.academia.edu/Documents/in/Dystonia?f_ri=87529"},{"id":239480,"name":"Neurotoxins","url":"https://www.academia.edu/Documents/in/Neurotoxins?f_ri=87529"},{"id":398219,"name":"Benign Prostatic Hyperplasia","url":"https://www.academia.edu/Documents/in/Benign_Prostatic_Hyperplasia?f_ri=87529"},{"id":561009,"name":"Nerve Block","url":"https://www.academia.edu/Documents/in/Nerve_Block?f_ri=87529"},{"id":995334,"name":"Neuromuscular Junction","url":"https://www.academia.edu/Documents/in/Neuromuscular_Junction?f_ri=87529"},{"id":1011135,"name":"Spinal Cord Injuries","url":"https://www.academia.edu/Documents/in/Spinal_Cord_Injuries?f_ri=87529"},{"id":1272678,"name":"Toxicon","url":"https://www.academia.edu/Documents/in/Toxicon?f_ri=87529"},{"id":1395441,"name":"Blepharospasm","url":"https://www.academia.edu/Documents/in/Blepharospasm?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_1620552" data-work_id="1620552" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/1620552/Relationship_between_food_specific_IgE_concentrations_and_the_risk_of_positive_food_challenges_in_children_and_adolescents">Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: The double-blind, placebo-controlled food challenge (DBPCFC) is the “gold standard” for diagnosis of food hypersensitivity. Skin prick tests and RASTs are sensitive indicators of food-specific IgE antibodies but poor... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_1620552" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: The double-blind, placebo-controlled food challenge (DBPCFC) is the “gold standard” for diagnosis of food hypersensitivity. Skin prick tests and RASTs are sensitive indicators of food-specific IgE antibodies but poor predictors of clinical reactivity. Previous studies suggested that high concentrations of food-specific IgE antibody were predictive of food-induced clinical symptoms. Because the CAP System FEIA (Pharmacia Diagnostics, Uppsala, Sweden) provides a quantitative assessment of allergen-specific IgE antibody, this study was undertaken to determine the potential utility of the CAP System FEIA in diagnosis of IgE-mediated food hypersensitivity. Methods: Sera from 196 patients with food allergy were analyzed for specific IgE antibodies to egg, milk, peanut, soy, wheat, and fish by CAP System FEIA. Sera were randomly selected from 300 stored samples of children and adolescents who had been evaluated by history, skin prick tests, and DBPCFCs. The study population was highly atopic; all patients had atopic dermatitis, and approximately 50% had asthma and allergic rhinitis at the time of initial evaluation. The performance characteristics of the CAP System FEIA were compared with those of skin prick tests and the outcome of DBPCFCs or “convincing” histories of anaphylactic reactions. Results: The prevalence of specific food allergies in the study population varied from 22% for wheat to 73% for egg. Allergy to egg, milk, peanut, and soy accounted for 87% of confirmed reactions. The performance characteristics of skin prick tests and CAP System FEIA (egg, milk, peanut, fish) were comparable, with excellent sensitivity and negative predictive accuracy but poor specificity and positive predictive accuracy. The performance characteristics of the CAP System FEIA for soy and wheat were poor. For egg, milk, peanut, and fish allergy, diagnostic levels of IgE, which could predict clinical reactivity in this population with greater than 95% certainty, were identified: egg, 6 kilounits of allergen-specific IgE per liter (kUA/L); milk, 32 kUA/L; peanut, 15 kUA/L; and fish, 20 kUA/L. Conclusions: When compared with the outcome of DBPCFCs, results of CAP System FEIA are generally comparable to those of skin prick tests in predicting symptomatic food hypersensitivity. Furthermore, by measuring the concentrations of food-specific IgE antibodies with the CAP System FEIA, it is possible to identify a subset of patients who are highly likely (>95%) to experience clinical reactions to egg, milk, peanut, or fish. This could eliminate the need to perform DBPCFCs in a significant number of patients suspected of having IgE-mediated food allergy. (J Allergy Clin Immunol 1997;100:444-51.)</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/1620552" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="cec1204a403b97dbca976615333b9761" rel="nofollow" data-download="{"attachment_id":50899029,"asset_id":1620552,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50899029/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1885562" href="https://jkuat.academia.edu/kenvinceotieno">kenvince otieno</a><script data-card-contents-for-user="1885562" type="text/json">{"id":1885562,"first_name":"kenvince","last_name":"otieno","domain_name":"jkuat","page_name":"kenvinceotieno","display_name":"kenvince otieno","profile_url":"https://jkuat.academia.edu/kenvinceotieno?f_ri=87529","photo":"https://0.academia-photos.com/1885562/638834/792274/s65_kenvince.otieno.jpg"}</script></span></span></li><li class="js-paper-rank-work_1620552 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="1620552"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 1620552, container: ".js-paper-rank-work_1620552", }); 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$(".js-view-count[data-work-id=1620552]").text(description); $(".js-view-count-work_1620552").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_1620552").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="1620552"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47258" href="https://www.academia.edu/Documents/in/Food_Allergy">Food Allergy</a>, <script data-card-contents-for-ri="47258" type="text/json">{"id":47258,"name":"Food Allergy","url":"https://www.academia.edu/Documents/in/Food_Allergy?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" href="https://www.academia.edu/Documents/in/Child">Child</a><script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=1620552]'), work: {"id":1620552,"title":"Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents","created_at":"2012-06-04T18:24:39.392-07:00","url":"https://www.academia.edu/1620552/Relationship_between_food_specific_IgE_concentrations_and_the_risk_of_positive_food_challenges_in_children_and_adolescents?f_ri=87529","dom_id":"work_1620552","summary":"Background: The double-blind, placebo-controlled food challenge (DBPCFC) is the “gold standard” for diagnosis of food hypersensitivity. Skin prick tests and RASTs are sensitive indicators of food-specific IgE antibodies but poor predictors of clinical reactivity. Previous studies suggested that high concentrations of food-specific IgE antibody were predictive of food-induced clinical symptoms. Because the CAP System FEIA (Pharmacia Diagnostics, Uppsala, Sweden) provides a quantitative assessment of allergen-specific IgE antibody, this study was undertaken to determine the potential utility of the CAP System FEIA in diagnosis of IgE-mediated food hypersensitivity. Methods: Sera from 196 patients with food allergy were analyzed for specific IgE antibodies to egg, milk, peanut, soy, wheat, and fish by CAP System FEIA. Sera were randomly selected from 300 stored samples of children and adolescents who had been evaluated by history, skin prick tests, and DBPCFCs. The study population was highly atopic; all patients had atopic dermatitis, and approximately 50% had asthma and allergic rhinitis at the time of initial evaluation. The performance characteristics of the CAP System FEIA were compared with those of skin prick tests and the outcome of DBPCFCs or “convincing” histories of anaphylactic reactions. Results: The prevalence of specific food allergies in the study population varied from 22% for wheat to 73% for egg. Allergy to egg, milk, peanut, and soy accounted for 87% of confirmed reactions. The performance characteristics of skin prick tests and CAP System FEIA (egg, milk, peanut, fish) were comparable, with excellent sensitivity and negative predictive accuracy but poor specificity and positive predictive accuracy. The performance characteristics of the CAP System FEIA for soy and wheat were poor. For egg, milk, peanut, and fish allergy, diagnostic levels of IgE, which could predict clinical reactivity in this population with greater than 95% certainty, were identified: egg, 6 kilounits of allergen-specific IgE per liter (kUA/L); milk, 32 kUA/L; peanut, 15 kUA/L; and fish, 20 kUA/L. Conclusions: When compared with the outcome of DBPCFCs, results of CAP System FEIA are generally comparable to those of skin prick tests in predicting symptomatic food hypersensitivity. Furthermore, by measuring the concentrations of food-specific IgE antibodies with the CAP System FEIA, it is possible to identify a subset of patients who are highly likely (\u003e95%) to experience clinical reactions to egg, milk, peanut, or fish. This could eliminate the need to perform DBPCFCs in a significant number of patients suspected of having IgE-mediated food allergy. (J Allergy Clin Immunol 1997;100:444-51.)","downloadable_attachments":[{"id":50899029,"asset_id":1620552,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":1885562,"first_name":"kenvince","last_name":"otieno","domain_name":"jkuat","page_name":"kenvinceotieno","display_name":"kenvince otieno","profile_url":"https://jkuat.academia.edu/kenvinceotieno?f_ri=87529","photo":"https://0.academia-photos.com/1885562/638834/792274/s65_kenvince.otieno.jpg"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=87529","nofollow":false},{"id":47258,"name":"Food Allergy","url":"https://www.academia.edu/Documents/in/Food_Allergy?f_ri=87529","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=87529"},{"id":158052,"name":"Placebos","url":"https://www.academia.edu/Documents/in/Placebos?f_ri=87529"},{"id":176180,"name":"Immunoglobulin E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E?f_ri=87529"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=87529"},{"id":258581,"name":"Children and Adolescents","url":"https://www.academia.edu/Documents/in/Children_and_Adolescents?f_ri=87529"},{"id":313752,"name":"Gold Standard","url":"https://www.academia.edu/Documents/in/Gold_Standard?f_ri=87529"},{"id":363788,"name":"Receiving Operating Characteristic","url":"https://www.academia.edu/Documents/in/Receiving_Operating_Characteristic?f_ri=87529"},{"id":591601,"name":"Atopic Dermatitis","url":"https://www.academia.edu/Documents/in/Atopic_Dermatitis?f_ri=87529"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=87529"},{"id":963657,"name":"Double Blind","url":"https://www.academia.edu/Documents/in/Double_Blind?f_ri=87529"},{"id":1309705,"name":"Receiver Operating Characteristic","url":"https://www.academia.edu/Documents/in/Receiver_Operating_Characteristic?f_ri=87529"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=87529"},{"id":1671808,"name":"Prediction Accuracy","url":"https://www.academia.edu/Documents/in/Prediction_Accuracy?f_ri=87529"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology?f_ri=87529"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_45417392" data-work_id="45417392" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/45417392/Spice_allergies_in_children">Spice allergies in children</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/45417392" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="03dd1f78b07210adaef5768023cfadd4" rel="nofollow" data-download="{"attachment_id":65931591,"asset_id":45417392,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/65931591/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="114304200" href="https://independent.academia.edu/FiocchiA">Alessandro Fiocchi</a><script data-card-contents-for-user="114304200" type="text/json">{"id":114304200,"first_name":"Alessandro","last_name":"Fiocchi","domain_name":"independent","page_name":"FiocchiA","display_name":"Alessandro Fiocchi","profile_url":"https://independent.academia.edu/FiocchiA?f_ri=87529","photo":"https://0.academia-photos.com/114304200/43801891/34689330/s65_alessandro.fiocchi.jpg"}</script></span></span></li><li class="js-paper-rank-work_45417392 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="45417392"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 45417392, container: ".js-paper-rank-work_45417392", }); });</script></li><li class="js-percentile-work_45417392 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" 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$(".js-view-count-work_45417392").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_45417392").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="45417392"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" href="https://www.academia.edu/Documents/in/Child">Child</a>, <script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a>, <script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="365458" href="https://www.academia.edu/Documents/in/Crocus">Crocus</a><script data-card-contents-for-ri="365458" type="text/json">{"id":365458,"name":"Crocus","url":"https://www.academia.edu/Documents/in/Crocus?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=45417392]'), work: {"id":45417392,"title":"Spice allergies in children","created_at":"2021-03-07T16:16:27.454-08:00","url":"https://www.academia.edu/45417392/Spice_allergies_in_children?f_ri=87529","dom_id":"work_45417392","summary":null,"downloadable_attachments":[{"id":65931591,"asset_id":45417392,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":114304200,"first_name":"Alessandro","last_name":"Fiocchi","domain_name":"independent","page_name":"FiocchiA","display_name":"Alessandro Fiocchi","profile_url":"https://independent.academia.edu/FiocchiA?f_ri=87529","photo":"https://0.academia-photos.com/114304200/43801891/34689330/s65_alessandro.fiocchi.jpg"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false},{"id":365458,"name":"Crocus","url":"https://www.academia.edu/Documents/in/Crocus?f_ri=87529","nofollow":false},{"id":480528,"name":"Spices","url":"https://www.academia.edu/Documents/in/Spices?f_ri=87529"},{"id":1232391,"name":"Budesonide","url":"https://www.academia.edu/Documents/in/Budesonide?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_32114363" data-work_id="32114363" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/32114363/Allergic_rhinitis_present_perspective">Allergic rhinitis: present perspective</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/32114363" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="04df71ccc23b644fd645ebe3cd4fba67" rel="nofollow" data-download="{"attachment_id":52361139,"asset_id":32114363,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/52361139/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="45416114" href="https://seu-bd.academia.edu/GolamRabbani">Golam Rabbani</a><script data-card-contents-for-user="45416114" type="text/json">{"id":45416114,"first_name":"Golam","last_name":"Rabbani","domain_name":"seu-bd","page_name":"GolamRabbani","display_name":"Golam Rabbani","profile_url":"https://seu-bd.academia.edu/GolamRabbani?f_ri=87529","photo":"https://0.academia-photos.com/45416114/12050917/16577112/s65_golam.rabbani.jpg"}</script></span></span></li><li class="js-paper-rank-work_32114363 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" 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data-has-card-for-ri="18895" href="https://www.academia.edu/Documents/in/Bangladesh">Bangladesh</a>, <script data-card-contents-for-ri="18895" type="text/json">{"id":18895,"name":"Bangladesh","url":"https://www.academia.edu/Documents/in/Bangladesh?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a><script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=32114363]'), work: {"id":32114363,"title":"Allergic rhinitis: present 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itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/50942903/Therapeutic_Potential_of_microRNA_Against_Th2_associated_Immune_Disorders">Therapeutic Potential of microRNA Against Th2-associated Immune Disorders</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">MicroRNAs (miRNAs) are short ~18-22 nucleotide, single-stranded, non-coding RNA molecules playing a crucial role in regulating diverse biological processes and are frequently dysregulated during disease pathogenesis. Thus, targeting miRNA... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_50942903" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">MicroRNAs (miRNAs) are short ~18-22 nucleotide, single-stranded, non-coding RNA molecules playing a crucial role in regulating diverse biological processes and are frequently dysregulated during disease pathogenesis. Thus, targeting miRNA could be a potential candidate for therapeutic invention. This systemic review aims to summarize our current understanding regarding the role of miRNAs associated with Th2-mediated immune disorders and strategies for therapeutic drug development and current clinical trials.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/50942903" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dd341585752d74d428f805a89a48ca34" rel="nofollow" data-download="{"attachment_id":68819810,"asset_id":50942903,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/68819810/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="3138098" href="https://sungkyunkwan.academia.edu/DrMuhammadUmerAshraf">Dr. Muhammad Umer Ashraf</a><script data-card-contents-for-user="3138098" type="text/json">{"id":3138098,"first_name":"Dr. Muhammad Umer","last_name":"Ashraf","domain_name":"sungkyunkwan","page_name":"DrMuhammadUmerAshraf","display_name":"Dr. Muhammad Umer Ashraf","profile_url":"https://sungkyunkwan.academia.edu/DrMuhammadUmerAshraf?f_ri=87529","photo":"https://0.academia-photos.com/3138098/1031551/1288869/s65_momi.smash.jpg"}</script></span></span></li><li class="js-paper-rank-work_50942903 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="50942903"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 50942903, container: ".js-paper-rank-work_50942903", }); 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style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21360790"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="4531" href="https://www.academia.edu/Documents/in/Clinical_Trial">Clinical Trial</a>, <script data-card-contents-for-ri="4531" type="text/json">{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a>, <script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="131233" href="https://www.academia.edu/Documents/in/Indian">Indian</a><script data-card-contents-for-ri="131233" type="text/json">{"id":131233,"name":"Indian","url":"https://www.academia.edu/Documents/in/Indian?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21360790]'), work: {"id":21360790,"title":"Oxymetazoline plus dexpanthenol in nasal congestion","created_at":"2016-01-31T22:53:09.934-08:00","url":"https://www.academia.edu/21360790/Oxymetazoline_plus_dexpanthenol_in_nasal_congestion?f_ri=87529","dom_id":"work_21360790","summary":null,"downloadable_attachments":[{"id":41833646,"asset_id":21360790,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":24253555,"first_name":"Deepak","last_name":"Langade","domain_name":"ypatil","page_name":"DeepakLangade","display_name":"Deepak 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href="https://www.academia.edu/14339724/Prevalence_of_Attention_Deficit_Hyperactivity_Disorder_in_a_Community_Sample_of_Older_Adolescents">Prevalence of Attention-Deficit/Hyperactivity Disorder in a Community Sample of Older Adolescents</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">ObjectiveTo study the prevalence and correlates of attention-deficit/hyperactivity disorder (ADHD) in a community sample of older adolescents.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14339724" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a 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Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2350" href="https://www.academia.edu/Documents/in/Attention-Deficit_Hyperactivity_Disorder">Attention-Deficit/Hyperactivity Disorder</a><script data-card-contents-for-ri="2350" type="text/json">{"id":2350,"name":"Attention-Deficit/Hyperactivity Disorder","url":"https://www.academia.edu/Documents/in/Attention-Deficit_Hyperactivity_Disorder?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14339724]'), work: 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href="https://www.academia.edu/25461041/Respiratory_symptoms_and_diseases_among_construction_painters">Respiratory symptoms and diseases among construction painters</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25461041" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ddd601cfcecc21181628027b16fb967e" rel="nofollow" data-download="{"attachment_id":45777877,"asset_id":25461041,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen 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href="https://www.academia.edu/21235201/Allergen_immunotherapy_A_practice_parameter_third_update">Allergen immunotherapy: A practice parameter third update</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21235201" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="046191d95e4d0adf406be0a344d58047" rel="nofollow" data-download="{"attachment_id":41775515,"asset_id":21235201,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen 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u-pv7x u-mb0x js-work-card work_9172032" data-work_id="9172032" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/9172032/Allergic_Rhinitis_and_its_Impact_on_Asthma_ARIA_2008_update_in_collaboration_with_the_World_Health_Organization_GA_2_LEN_and_AllerGen">Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/9172032" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" 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and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology?f_ri=87529"},{"id":2463778,"name":"Clinical Trials as Topic","url":"https://www.academia.edu/Documents/in/Clinical_Trials_as_Topic?f_ri=87529"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_4290460" data-work_id="4290460" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/4290460/Nettle_extract_Urtica_dioica_affects_key_receptors_and_enzymes_associated_with_allergic_rhinitis">Nettle extract ( Urtica dioica ) affects key receptors and enzymes associated with allergic rhinitis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A nettle (Urtica dioica) extract shows in vitro inhibition of several key inflammatory events that cause the symptoms of seasonal allergies. These include the antagonist and negative agonist activity against the Histamine-1 (H1) receptor... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_4290460" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A nettle (Urtica dioica) extract shows in vitro inhibition of several key inflammatory events that cause the symptoms of seasonal allergies. These include the antagonist and negative agonist activity against the Histamine-1 (H1) receptor and the inhibition of mast cell tryptase preventing degranulation and release of a host of pro-inflammatory mediators that cause the symptoms of hay fevers. The nettle extract also inhibits prostaglandin formation through inhibition of Cyclooxygenase-1 (COX-1), Cyclooxygenase-2 (COX-2), and Hematopoietic Prostaglandin D2 synthase (HPGDS), central enzymes in pro-inflammatory pathways. The IC50 value for histamine receptor antagonist activity was 251 (±13) µg mL−1 and for the histamine receptor negative agonist activity was 193 (±71) µg mL−1. The IC50 values for inhibition of mast cell tryptase was 172 (±28) µg mL−1, for COX-1 was 160 (±47) µg mL−1, for COX-2 was 275 (±9) µg mL−1, and for HPGDS was 295 (±51) µg mL−1. Through the use of DART TOF-MS, which yields exact masses and relative abundances of compounds present in complex mixtures, bioactives have been identified in nettle that contribute to the inhibition of pro-inflammatory pathways related to allergic rhinitis. These results provide for the first time, a mechanistic understanding of the role of nettle extracts in reducing allergic and other inflammatory responses in vitro. Copyright © 2009 John Wiley & Sons, Ltd.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4290460" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7273f30b2c1294d2ca489a103b208281" rel="nofollow" data-download="{"attachment_id":49957435,"asset_id":4290460,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49957435/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5213775" href="https://independent.academia.edu/BillRoschek">Bill Roschek</a><script data-card-contents-for-user="5213775" type="text/json">{"id":5213775,"first_name":"Bill","last_name":"Roschek","domain_name":"independent","page_name":"BillRoschek","display_name":"Bill Roschek","profile_url":"https://independent.academia.edu/BillRoschek?f_ri=87529","photo":"https://0.academia-photos.com/5213775/12124040/13504518/s65_bill.roschek.jpg"}</script></span></span></li><li class="js-paper-rank-work_4290460 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="4290460"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 4290460, container: ".js-paper-rank-work_4290460", }); 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These include the antagonist and negative agonist activity against the Histamine-1 (H1) receptor and the inhibition of mast cell tryptase preventing degranulation and release of a host of pro-inflammatory mediators that cause the symptoms of hay fevers. The nettle extract also inhibits prostaglandin formation through inhibition of Cyclooxygenase-1 (COX-1), Cyclooxygenase-2 (COX-2), and Hematopoietic Prostaglandin D2 synthase (HPGDS), central enzymes in pro-inflammatory pathways. The IC50 value for histamine receptor antagonist activity was 251 (±13) µg mL−1 and for the histamine receptor negative agonist activity was 193 (±71) µg mL−1. The IC50 values for inhibition of mast cell tryptase was 172 (±28) µg mL−1, for COX-1 was 160 (±47) µg mL−1, for COX-2 was 275 (±9) µg mL−1, and for HPGDS was 295 (±51) µg mL−1. Through the use of DART TOF-MS, which yields exact masses and relative abundances of compounds present in complex mixtures, bioactives have been identified in nettle that contribute to the inhibition of pro-inflammatory pathways related to allergic rhinitis. These results provide for the first time, a mechanistic understanding of the role of nettle extracts in reducing allergic and other inflammatory responses in vitro. Copyright © 2009 John Wiley \u0026 Sons, Ltd.","downloadable_attachments":[{"id":49957435,"asset_id":4290460,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5213775,"first_name":"Bill","last_name":"Roschek","domain_name":"independent","page_name":"BillRoschek","display_name":"Bill Roschek","profile_url":"https://independent.academia.edu/BillRoschek?f_ri=87529","photo":"https://0.academia-photos.com/5213775/12124040/13504518/s65_bill.roschek.jpg"}],"research_interests":[{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=87529","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=87529","nofollow":false},{"id":52027,"name":"Phytotherapy","url":"https://www.academia.edu/Documents/in/Phytotherapy?f_ri=87529","nofollow":false},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme?f_ri=87529"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES?f_ri=87529"},{"id":354056,"name":"Plant extracts","url":"https://www.academia.edu/Documents/in/Plant_extracts?f_ri=87529"},{"id":1969304,"name":"Urtica dioica","url":"https://www.academia.edu/Documents/in/Urtica_dioica?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13848674" data-work_id="13848674" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13848674/Allergic_Rhinitis_and_its_Impact_on_Asthma_ARIA_Achievements_in_10_years_and_future_needs">Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13848674" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e402076aefdeb95594e1113d2616ab77" rel="nofollow" data-download="{"attachment_id":44883134,"asset_id":13848674,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44883134/download_file?st=MTczMjY5OTEyMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32942983" href="https://wum.academia.edu/BSamolinski">B. 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Hewan kasus menunjukkan gejala klinis berupa adanya leleran hidung yang sudah mengering pada hidung bagian kanan, mukosa hidung... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_37753100" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">ABSTRAK Hewan kasus adalah seekor kucing lokal bernama Embul, berjenis kelamin jantan dan berumur 6 bulan. Hewan kasus menunjukkan gejala klinis berupa adanya leleran hidung yang sudah mengering pada hidung bagian kanan, mukosa hidung terlihat kemerahan pada hidung bagian kanan, kucing terlihat bersin, dan limfonodus mandibular sebelah kanan lebih besar dari yang sebelah kiri. Pada pemeriksaan hematologi rutin hasil menunjukkan polisitemia dan eosinofilia. Berdasarkan pemeriksaan yang telah dilakukan, hewan didiagnosa rhinitis pada bagian hidung sebelah kanan (unilateral). Terapi yang diberikan adalah pemberian antibiotic Amoxicillin dengan sediaan 250 mg (11-22 mg/kg BB), injeksi Dipenhidramin 10 mg/ml (2-4 mg/kg BB) dan per oral Dipenhidramin diberikan sediaan 25 mg (2-4mg/kg BB), serta diberikan vitamin B-Complex satu tablet per hari. ABSTRACT The case animal is local cat named Embul, male and 6 months old. The cat showed symptoms of the presence of a runny nose that has dried on the right nose, the nasal mucosa is reddish on the right nose, the cat looks sneezing, and the right mandibular lymph node is larger than the left. Routine hematology examination resulted in polycitemia and eosinophilia. According to the all examination, the cat was diagnosed with rhinitis in the right nasal passage (unilateral). Treatments that was therapy with Amoxicillin antibiotic 250 mg (11-22 mg/kg), inject with Dipenhidramin 10 mg/ml (2-4 mg/kg), per oral Dipenhidramin 25 mg (2-4mg/kg), and B-Complex vitamin one tablet for a day.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/37753100" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="891d0b961fa8b2ec946388401396dbeb" rel="nofollow" data-download="{"attachment_id":57748815,"asset_id":37753100,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/57748815/download_file?st=MTczMjY5OTEyMiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="10976953" href="https://udayana.academia.edu/GraceSimatupang">Grace Tabitha Tenggi Olihta Simatupang</a><script data-card-contents-for-user="10976953" type="text/json">{"id":10976953,"first_name":"Grace Tabitha Tenggi Olihta","last_name":"Simatupang","domain_name":"udayana","page_name":"GraceSimatupang","display_name":"Grace Tabitha Tenggi Olihta Simatupang","profile_url":"https://udayana.academia.edu/GraceSimatupang?f_ri=87529","photo":"https://0.academia-photos.com/10976953/4271339/20648090/s65_grace_tabitha_tenggi_olihta.simatupang.jpg"}</script></span></span></li><li class="js-paper-rank-work_37753100 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="37753100"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 37753100, container: ".js-paper-rank-work_37753100", }); 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$(".js-view-count[data-work-id=37753100]").text(description); $(".js-view-count-work_37753100").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_37753100").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="37753100"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="3233" href="https://www.academia.edu/Documents/in/Animal_Studies">Animal Studies</a>, <script data-card-contents-for-ri="3233" type="text/json">{"id":3233,"name":"Animal Studies","url":"https://www.academia.edu/Documents/in/Animal_Studies?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a><script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=37753100]'), work: {"id":37753100,"title":"Laporan Kasus : Rhinitis Unilateral pada Kucing Lokal (Case Report : Unilateral Rhinitis in Local Cat)","created_at":"2018-11-12T07:17:59.223-08:00","url":"https://www.academia.edu/37753100/Laporan_Kasus_Rhinitis_Unilateral_pada_Kucing_Lokal_Case_Report_Unilateral_Rhinitis_in_Local_Cat_?f_ri=87529","dom_id":"work_37753100","summary":"ABSTRAK Hewan kasus adalah seekor kucing lokal bernama Embul, berjenis kelamin jantan dan berumur 6 bulan. Hewan kasus menunjukkan gejala klinis berupa adanya leleran hidung yang sudah mengering pada hidung bagian kanan, mukosa hidung terlihat kemerahan pada hidung bagian kanan, kucing terlihat bersin, dan limfonodus mandibular sebelah kanan lebih besar dari yang sebelah kiri. Pada pemeriksaan hematologi rutin hasil menunjukkan polisitemia dan eosinofilia. Berdasarkan pemeriksaan yang telah dilakukan, hewan didiagnosa rhinitis pada bagian hidung sebelah kanan (unilateral). Terapi yang diberikan adalah pemberian antibiotic Amoxicillin dengan sediaan 250 mg (11-22 mg/kg BB), injeksi Dipenhidramin 10 mg/ml (2-4 mg/kg BB) dan per oral Dipenhidramin diberikan sediaan 25 mg (2-4mg/kg BB), serta diberikan vitamin B-Complex satu tablet per hari. ABSTRACT The case animal is local cat named Embul, male and 6 months old. The cat showed symptoms of the presence of a runny nose that has dried on the right nose, the nasal mucosa is reddish on the right nose, the cat looks sneezing, and the right mandibular lymph node is larger than the left. Routine hematology examination resulted in polycitemia and eosinophilia. According to the all examination, the cat was diagnosed with rhinitis in the right nasal passage (unilateral). Treatments that was therapy with Amoxicillin antibiotic 250 mg (11-22 mg/kg), inject with Dipenhidramin 10 mg/ml (2-4 mg/kg), per oral Dipenhidramin 25 mg (2-4mg/kg), and B-Complex vitamin one tablet for a day.","downloadable_attachments":[{"id":57748815,"asset_id":37753100,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":10976953,"first_name":"Grace Tabitha Tenggi Olihta","last_name":"Simatupang","domain_name":"udayana","page_name":"GraceSimatupang","display_name":"Grace Tabitha Tenggi Olihta Simatupang","profile_url":"https://udayana.academia.edu/GraceSimatupang?f_ri=87529","photo":"https://0.academia-photos.com/10976953/4271339/20648090/s65_grace_tabitha_tenggi_olihta.simatupang.jpg"}],"research_interests":[{"id":3233,"name":"Animal Studies","url":"https://www.academia.edu/Documents/in/Animal_Studies?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_72138615" data-work_id="72138615" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/72138615/Computational_analysis_of_multimorbidity_between_asthma_eczema_and_rhinitis">Computational analysis of multimorbidity between asthma, eczema and rhinitis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The mechanisms explaining the co-existence of asthma, eczema and rhinitis (allergic multimorbidity) are largely unknown. We investigated the mechanisms underlying multimorbidity between three main allergic diseases at a molecular level by... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_72138615" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The mechanisms explaining the co-existence of asthma, eczema and rhinitis (allergic multimorbidity) are largely unknown. We investigated the mechanisms underlying multimorbidity between three main allergic diseases at a molecular level by identifying the proteins and cellular processes that are common to them. An in silico study based on computational analysis of the topology of the protein interaction network was performed in order to characterize the molecular mechanisms of multimorbidity of asthma, eczema and rhinitis. As a first step, proteins associated to either disease were identified using data mining approaches, and their overlap was calculated. Secondly, a functional interaction network was built, allowing to identify cellular pathways involved in allergic multimorbidity. Finally, a network-based algorithm generated a ranked list of newly predicted multimorbidity-associated proteins. Asthma, eczema and rhinitis shared a larger number of associated proteins than expected by...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/72138615" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ba5d074ada740147e89765154c38d390" rel="nofollow" data-download="{"attachment_id":81187911,"asset_id":72138615,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81187911/download_file?st=MTczMjY5OTEyMiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="144524" href="https://upf.academia.edu/boliva">baldo oliva</a><script data-card-contents-for-user="144524" type="text/json">{"id":144524,"first_name":"baldo","last_name":"oliva","domain_name":"upf","page_name":"boliva","display_name":"baldo oliva","profile_url":"https://upf.academia.edu/boliva?f_ri=87529","photo":"https://0.academia-photos.com/144524/86318/94246/s65_baldo.oliva.jpg"}</script></span></span></li><li class="js-paper-rank-work_72138615 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="72138615"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 72138615, container: ".js-paper-rank-work_72138615", }); 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We investigated the mechanisms underlying multimorbidity between three main allergic diseases at a molecular level by identifying the proteins and cellular processes that are common to them. An in silico study based on computational analysis of the topology of the protein interaction network was performed in order to characterize the molecular mechanisms of multimorbidity of asthma, eczema and rhinitis. As a first step, proteins associated to either disease were identified using data mining approaches, and their overlap was calculated. Secondly, a functional interaction network was built, allowing to identify cellular pathways involved in allergic multimorbidity. Finally, a network-based algorithm generated a ranked list of newly predicted multimorbidity-associated proteins. Asthma, eczema and rhinitis shared a larger number of associated proteins than expected by...","downloadable_attachments":[{"id":81187911,"asset_id":72138615,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":144524,"first_name":"baldo","last_name":"oliva","domain_name":"upf","page_name":"boliva","display_name":"baldo 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Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation?f_ri=87529"},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one?f_ri=87529"},{"id":343667,"name":"Theoretical Models","url":"https://www.academia.edu/Documents/in/Theoretical_Models?f_ri=87529"},{"id":613465,"name":"Statistical models","url":"https://www.academia.edu/Documents/in/Statistical_models?f_ri=87529"},{"id":1035050,"name":"Proteome","url":"https://www.academia.edu/Documents/in/Proteome?f_ri=87529"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation?f_ri=87529"},{"id":1799441,"name":"Rhinitis","url":"https://www.academia.edu/Documents/in/Rhinitis?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14190016" data-work_id="14190016" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14190016/Allergic_Rhinitis_and_Its_Impact_on_Asthma">Allergic Rhinitis and Its Impact on Asthma</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14190016" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c8fb67e0a0eee7817243248ee0a524e1" rel="nofollow" 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Medicine","url":"https://www.academia.edu/Documents/in/Evidence_Based_Medicine?f_ri=87529","nofollow":false},{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health?f_ri=87529","nofollow":false},{"id":9815,"name":"Developing Countries","url":"https://www.academia.edu/Documents/in/Developing_Countries?f_ri=87529"},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=87529"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=87529"},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=87529"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529"},{"id":75826,"name":"Europe","url":"https://www.academia.edu/Documents/in/Europe?f_ri=87529"},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=87529"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=87529"},{"id":212786,"name":"Austria","url":"https://www.academia.edu/Documents/in/Austria?f_ri=87529"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=87529"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=87529"},{"id":418354,"name":"Evidence Based","url":"https://www.academia.edu/Documents/in/Evidence_Based?f_ri=87529"},{"id":521881,"name":"World Health Organization","url":"https://www.academia.edu/Documents/in/World_Health_Organization?f_ri=87529"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=87529"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22603262" data-work_id="22603262" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22603262/Formulation_and_Evaluation_of_Immediate_Release_Tablets_of_Fexofenadine_Hydrochloride">Formulation and Evaluation of Immediate Release Tablets of Fexofenadine Hydrochloride</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The present research work is to develop immediate release tablets of Fexofenadine hydrochloride. The rate of dissolution and bioavailability of the Fexofenadine HCL has been increased by using superdisintegrants in its immediate release... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22603262" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The present research work is to develop immediate release tablets of Fexofenadine hydrochloride. The rate of dissolution and bioavailability of the Fexofenadine HCL has been increased by using superdisintegrants in its immediate release tablets. Direct compression method was adapted to prepare the tablets by using Sodium lauryl sulphate, microcrystalline cellulose as filler, crospovidone and sodium starch glycolate as superdisintegrant in different concentration (2-8%). Tablets were prepared and evaluated pre and post compressional parameters. In-Vitro Disintegration study shows that as there is increase in disintegration time with increase in concentration of sodium starch glycolate while there is decrease in disintegration time with increase in the level of crospovidone. The results indicate that the selected batch of tablet formulation containing crospovidone provides disintegration time between 3-6 minutes with sufficient crushing strength and accepted friability. It was concluded that immediate release tablet for Fexofenadine hydrochloride can be formulated for fast treatment of allergic rhinitis. INTRODUCTION 1,2 In the last 15 to 20 years, there has been a huge resource in both academia and industry devoted to the development of drug delivery systems that target drugs more effectively to their therapeutic site. Much of this work has been successful and is reported within this text. In spite of this, oral solid dosage forms such as tablets and hard gelatin capsules, which have been in existence since the nineteenth century, remain the most frequently used dosage forms. This is not simply a reflection of the continued use of established products on the market, tablets and capsules still account for about half of all new medicines licensed.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22603262" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="51177e4aa8e66a238940e03f9b2a57cb" rel="nofollow" data-download="{"attachment_id":43203831,"asset_id":22603262,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43203831/download_file?st=MTczMjY5OTEyMiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="30094541" href="https://jprsolutions.academia.edu/JOURNALOFPHARMACYRESEARCH">JPR Solutions</a><script data-card-contents-for-user="30094541" type="text/json">{"id":30094541,"first_name":"JPR","last_name":"Solutions","domain_name":"jprsolutions","page_name":"JOURNALOFPHARMACYRESEARCH","display_name":"JPR Solutions","profile_url":"https://jprsolutions.academia.edu/JOURNALOFPHARMACYRESEARCH?f_ri=87529","photo":"https://0.academia-photos.com/30094541/10117086/11288208/s65_swapnadeep.parial.jpg"}</script></span></span></li><li class="js-paper-rank-work_22603262 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22603262"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22603262, container: ".js-paper-rank-work_22603262", }); 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$(".js-view-count[data-work-id=22603262]").text(description); $(".js-view-count-work_22603262").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_22603262").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="22603262"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="41745" href="https://www.academia.edu/Documents/in/Pharmaceutics">Pharmaceutics</a>, <script data-card-contents-for-ri="41745" type="text/json">{"id":41745,"name":"Pharmaceutics","url":"https://www.academia.edu/Documents/in/Pharmaceutics?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="59918" href="https://www.academia.edu/Documents/in/Quality_Assurance">Quality Assurance</a>, <script data-card-contents-for-ri="59918" type="text/json">{"id":59918,"name":"Quality Assurance","url":"https://www.academia.edu/Documents/in/Quality_Assurance?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a>, <script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2411050" href="https://www.academia.edu/Documents/in/Fexofenadine_Hydrochloride">Fexofenadine Hydrochloride</a><script data-card-contents-for-ri="2411050" type="text/json">{"id":2411050,"name":"Fexofenadine Hydrochloride","url":"https://www.academia.edu/Documents/in/Fexofenadine_Hydrochloride?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22603262]'), work: {"id":22603262,"title":"Formulation and Evaluation of Immediate Release Tablets of Fexofenadine Hydrochloride","created_at":"2016-02-29T08:16:12.673-08:00","url":"https://www.academia.edu/22603262/Formulation_and_Evaluation_of_Immediate_Release_Tablets_of_Fexofenadine_Hydrochloride?f_ri=87529","dom_id":"work_22603262","summary":"The present research work is to develop immediate release tablets of Fexofenadine hydrochloride. The rate of dissolution and bioavailability of the Fexofenadine HCL has been increased by using superdisintegrants in its immediate release tablets. Direct compression method was adapted to prepare the tablets by using Sodium lauryl sulphate, microcrystalline cellulose as filler, crospovidone and sodium starch glycolate as superdisintegrant in different concentration (2-8%). Tablets were prepared and evaluated pre and post compressional parameters. In-Vitro Disintegration study shows that as there is increase in disintegration time with increase in concentration of sodium starch glycolate while there is decrease in disintegration time with increase in the level of crospovidone. The results indicate that the selected batch of tablet formulation containing crospovidone provides disintegration time between 3-6 minutes with sufficient crushing strength and accepted friability. It was concluded that immediate release tablet for Fexofenadine hydrochloride can be formulated for fast treatment of allergic rhinitis. INTRODUCTION 1,2 In the last 15 to 20 years, there has been a huge resource in both academia and industry devoted to the development of drug delivery systems that target drugs more effectively to their therapeutic site. Much of this work has been successful and is reported within this text. In spite of this, oral solid dosage forms such as tablets and hard gelatin capsules, which have been in existence since the nineteenth century, remain the most frequently used dosage forms. This is not simply a reflection of the continued use of established products on the market, tablets and capsules still account for about half of all new medicines licensed.","downloadable_attachments":[{"id":43203831,"asset_id":22603262,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":30094541,"first_name":"JPR","last_name":"Solutions","domain_name":"jprsolutions","page_name":"JOURNALOFPHARMACYRESEARCH","display_name":"JPR Solutions","profile_url":"https://jprsolutions.academia.edu/JOURNALOFPHARMACYRESEARCH?f_ri=87529","photo":"https://0.academia-photos.com/30094541/10117086/11288208/s65_swapnadeep.parial.jpg"}],"research_interests":[{"id":41745,"name":"Pharmaceutics","url":"https://www.academia.edu/Documents/in/Pharmaceutics?f_ri=87529","nofollow":false},{"id":59918,"name":"Quality Assurance","url":"https://www.academia.edu/Documents/in/Quality_Assurance?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false},{"id":2411050,"name":"Fexofenadine Hydrochloride","url":"https://www.academia.edu/Documents/in/Fexofenadine_Hydrochloride?f_ri=87529","nofollow":false},{"id":2411051,"name":"Immediate Release Tablets","url":"https://www.academia.edu/Documents/in/Immediate_Release_Tablets?f_ri=87529"},{"id":2411052,"name":"Crospovidone","url":"https://www.academia.edu/Documents/in/Crospovidone?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18840017" data-work_id="18840017" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18840017/Recommandation_pour_le_diagnostic_et_la_prise_en_charge_de_la_rhinite_allergique_%C3%A9pid%C3%A9miologie_et_pathophysiologie_exclues_texte_court">Recommandation pour le diagnostic et la prise en charge de la rhinite allergique (épidémiologie et pathophysiologie exclues)–texte court</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Allergic rhinitis is a global health problem due to its impact on quality of life of the patient and its health-care costs. The authors propose a consensus statement (Guidelines) on the diagnosis and management of allergic rhinitis... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18840017" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Allergic rhinitis is a global health problem due to its impact on quality of life of the patient and its health-care costs. The authors propose a consensus statement (Guidelines) on the diagnosis and management of allergic rhinitis exclusive of epidemiology and pathophysiology. They have followed the ADAPTE procedure, validated by the French health authorities to adapt ARIA to the French</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18840017" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="28df5c9b9594c9ac3ec0912b777aa63e" rel="nofollow" data-download="{"attachment_id":42132973,"asset_id":18840017,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42132973/download_file?st=MTczMjY5OTEyMiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38939832" href="https://independent.academia.edu/PDevillier">P. 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The authors propose a consensus statement (Guidelines) on the diagnosis and management of allergic rhinitis exclusive of epidemiology and pathophysiology. They have followed the ADAPTE procedure, validated by the French health authorities to adapt ARIA to the French","downloadable_attachments":[{"id":42132973,"asset_id":18840017,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38939832,"first_name":"P.","last_name":"Devillier","domain_name":"independent","page_name":"PDevillier","display_name":"P. Devillier","profile_url":"https://independent.academia.edu/PDevillier?f_ri=87529","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health?f_ri=87529","nofollow":false},{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=87529","nofollow":false},{"id":20212,"name":"Allergic asthma","url":"https://www.academia.edu/Documents/in/Allergic_asthma?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13767132 coauthored" data-work_id="13767132" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13767132/Probiotics_and_immunity">Probiotics and immunity</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13767132" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e11d165eee101a60ba5951bbe8ff6a75" rel="nofollow" data-download="{"attachment_id":44975909,"asset_id":13767132,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13767132]").text(description); $(".js-view-count-work_13767132").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13767132").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13767132"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3274" href="https://www.academia.edu/Documents/in/Gastroenterology">Gastroenterology</a>, <script data-card-contents-for-ri="3274" type="text/json">{"id":3274,"name":"Gastroenterology","url":"https://www.academia.edu/Documents/in/Gastroenterology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4542" href="https://www.academia.edu/Documents/in/Probiotics">Probiotics</a>, <script data-card-contents-for-ri="4542" type="text/json">{"id":4542,"name":"Probiotics","url":"https://www.academia.edu/Documents/in/Probiotics?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9334" href="https://www.academia.edu/Documents/in/Inflammation">Inflammation</a>, <script data-card-contents-for-ri="9334" type="text/json">{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="24706" href="https://www.academia.edu/Documents/in/Innate_immunity">Innate immunity</a><script data-card-contents-for-ri="24706" type="text/json">{"id":24706,"name":"Innate immunity","url":"https://www.academia.edu/Documents/in/Innate_immunity?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13767132]'), work: {"id":13767132,"title":"Probiotics and immunity","created_at":"2015-07-07T14:23:38.955-07:00","url":"https://www.academia.edu/13767132/Probiotics_and_immunity?f_ri=87529","dom_id":"work_13767132","summary":null,"downloadable_attachments":[{"id":44975909,"asset_id":13767132,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32879455,"first_name":"Carl","last_name":"Keen","domain_name":"ucdavis","page_name":"CarlKeen","display_name":"Carl Keen","profile_url":"https://ucdavis.academia.edu/CarlKeen?f_ri=87529","photo":"/images/s65_no_pic.png"},{"id":32945679,"first_name":"Frederick","last_name":"Meyers","domain_name":"independent","page_name":"MeyersFrederick","display_name":"Frederick Meyers","profile_url":"https://independent.academia.edu/MeyersFrederick?f_ri=87529","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3274,"name":"Gastroenterology","url":"https://www.academia.edu/Documents/in/Gastroenterology?f_ri=87529","nofollow":false},{"id":4542,"name":"Probiotics","url":"https://www.academia.edu/Documents/in/Probiotics?f_ri=87529","nofollow":false},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=87529","nofollow":false},{"id":24706,"name":"Innate immunity","url":"https://www.academia.edu/Documents/in/Innate_immunity?f_ri=87529","nofollow":false},{"id":35539,"name":"Dendritic Cells","url":"https://www.academia.edu/Documents/in/Dendritic_Cells?f_ri=87529"},{"id":84924,"name":"Immunity","url":"https://www.academia.edu/Documents/in/Immunity?f_ri=87529"},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=87529"},{"id":151951,"name":"Animal Model","url":"https://www.academia.edu/Documents/in/Animal_Model?f_ri=87529"},{"id":225472,"name":"Inflammatory disease","url":"https://www.academia.edu/Documents/in/Inflammatory_disease?f_ri=87529"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=87529"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=87529"},{"id":537759,"name":"Gastrointestinal Tract","url":"https://www.academia.edu/Documents/in/Gastrointestinal_Tract?f_ri=87529"},{"id":591601,"name":"Atopic Dermatitis","url":"https://www.academia.edu/Documents/in/Atopic_Dermatitis?f_ri=87529"},{"id":675427,"name":"Immune function","url":"https://www.academia.edu/Documents/in/Immune_function?f_ri=87529"},{"id":784771,"name":"Dietary Supplement","url":"https://www.academia.edu/Documents/in/Dietary_Supplement?f_ri=87529"},{"id":951639,"name":"Murine Model","url":"https://www.academia.edu/Documents/in/Murine_Model?f_ri=87529"},{"id":1015202,"name":"Hypersensitivity","url":"https://www.academia.edu/Documents/in/Hypersensitivity?f_ri=87529"},{"id":1924429,"name":"AIRWAY HYPERRESPONSIVENESS","url":"https://www.academia.edu/Documents/in/AIRWAY_HYPERRESPONSIVENESS?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_38407854" data-work_id="38407854" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/38407854/Homeopathy_for_Allergic_Rhinitis_A_Systematic_Review">Homeopathy for Allergic Rhinitis: A Systematic Review</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: The aim of this study was to evaluate the efficacy and effectiveness of homeopathic intervention in the treatment of seasonal or perennial allergic rhinitis (AR). Method: Randomized controlled trials evaluating all forms of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_38407854" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: The aim of this study was to evaluate the efficacy and effectiveness of homeopathic intervention in<br />the treatment of seasonal or perennial allergic rhinitis (AR).<br />Method: Randomized controlled trials evaluating all forms of homeopathic treatment for AR were included<br />in a systematic review (SR) of studies published up to and including December 2015. Two authors independently<br />screened potential studies, extracted data, and assessed risk of bias. Primary outcomes included symptom<br />improvement and total quality-of-life score. Treatment effect size was quantified as mean difference (continuous<br />data), or by risk ratio (RR) and odds ratio (dichotomous data), with 95% confidence intervals (CI). Metaanalysis<br />was performed after assessing heterogeneity and risk of bias.<br />Results: Eleven studies were eligible for SR. All trials were placebo-controlled except one. Six trials used the<br />treatment approach known as isopathy, but they were unsuitable for meta-analysis due to problems of heterogeneity<br />and data extraction. The overall standard of methods and reporting was poor: 8/11 trials were<br />assessed as ‘‘high risk of bias’’; only one trial, on isopathy for seasonal AR, possessed reliable evidence. Three<br />trials of variable quality (all using Galphimia glauca for seasonal AR) were included in the meta-analysis: nasal<br />symptom relief at 2 and 4 weeks (RR = 1.48 [95% CI 1.24–1.77] and 1.27 [95% CI 1.10–1.46], respectively)<br />favored homeopathy compared with placebo; ocular symptom relief at 2 and 4 weeks also favored homeopathy<br />(RR = 1.55 [95% CI 1.33–1.80] and 1.37 [95% CI 1.21–1.56], respectively). The single trial with reliable<br />evidence had a small positive treatment effect without statistical significance. A homeopathic and a conventional<br />nasal spray produced equivalent improvements in nasal and ocular symptoms.<br />Conclusions: The low or uncertain overall quality of the evidence warrants caution in drawing firm conclusions<br />about intervention effects. Use of either Galphimia glauca or a homeopathic nasal spray may have small beneficial<br />effects on the nasal and ocular symptoms of AR. The efficacy of isopathic treatment of AR is unclear.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/38407854" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b8b2b2adff1a5735cd48b1d4768ecc88" rel="nofollow" data-download="{"attachment_id":58465759,"asset_id":38407854,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/58465759/download_file?st=MTczMjY5OTEyMiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="3412352" href="https://leicester.academia.edu/JeremyHowick">Jeremy Howick</a><script data-card-contents-for-user="3412352" type="text/json">{"id":3412352,"first_name":"Jeremy","last_name":"Howick","domain_name":"leicester","page_name":"JeremyHowick","display_name":"Jeremy Howick","profile_url":"https://leicester.academia.edu/JeremyHowick?f_ri=87529","photo":"https://0.academia-photos.com/3412352/1169130/1465672/s65_jeremy.howick.jpg"}</script></span></span></li><li class="js-paper-rank-work_38407854 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="38407854"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 38407854, container: ".js-paper-rank-work_38407854", }); });</script></li><li class="js-percentile-work_38407854 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 38407854; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_38407854"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_38407854 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="38407854"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 38407854; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=38407854]").text(description); $(".js-view-count-work_38407854").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_38407854").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="38407854"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="6482" href="https://www.academia.edu/Documents/in/Meta-Analysis_and_Systematic_Review">Meta-Analysis and Systematic Review</a>, <script data-card-contents-for-ri="6482" type="text/json">{"id":6482,"name":"Meta-Analysis and Systematic Review","url":"https://www.academia.edu/Documents/in/Meta-Analysis_and_Systematic_Review?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a><script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=38407854]'), work: {"id":38407854,"title":"Homeopathy for Allergic Rhinitis: A Systematic Review","created_at":"2019-02-21T08:44:21.544-08:00","url":"https://www.academia.edu/38407854/Homeopathy_for_Allergic_Rhinitis_A_Systematic_Review?f_ri=87529","dom_id":"work_38407854","summary":"Objective: The aim of this study was to evaluate the efficacy and effectiveness of homeopathic intervention in\nthe treatment of seasonal or perennial allergic rhinitis (AR).\nMethod: Randomized controlled trials evaluating all forms of homeopathic treatment for AR were included\nin a systematic review (SR) of studies published up to and including December 2015. Two authors independently\nscreened potential studies, extracted data, and assessed risk of bias. Primary outcomes included symptom\nimprovement and total quality-of-life score. Treatment effect size was quantified as mean difference (continuous\ndata), or by risk ratio (RR) and odds ratio (dichotomous data), with 95% confidence intervals (CI). Metaanalysis\nwas performed after assessing heterogeneity and risk of bias.\nResults: Eleven studies were eligible for SR. All trials were placebo-controlled except one. Six trials used the\ntreatment approach known as isopathy, but they were unsuitable for meta-analysis due to problems of heterogeneity\nand data extraction. The overall standard of methods and reporting was poor: 8/11 trials were\nassessed as ‘‘high risk of bias’’; only one trial, on isopathy for seasonal AR, possessed reliable evidence. Three\ntrials of variable quality (all using Galphimia glauca for seasonal AR) were included in the meta-analysis: nasal\nsymptom relief at 2 and 4 weeks (RR = 1.48 [95% CI 1.24–1.77] and 1.27 [95% CI 1.10–1.46], respectively)\nfavored homeopathy compared with placebo; ocular symptom relief at 2 and 4 weeks also favored homeopathy\n(RR = 1.55 [95% CI 1.33–1.80] and 1.37 [95% CI 1.21–1.56], respectively). The single trial with reliable\nevidence had a small positive treatment effect without statistical significance. A homeopathic and a conventional\nnasal spray produced equivalent improvements in nasal and ocular symptoms.\nConclusions: The low or uncertain overall quality of the evidence warrants caution in drawing firm conclusions\nabout intervention effects. Use of either Galphimia glauca or a homeopathic nasal spray may have small beneficial\neffects on the nasal and ocular symptoms of AR. The efficacy of isopathic treatment of AR is unclear.","downloadable_attachments":[{"id":58465759,"asset_id":38407854,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":3412352,"first_name":"Jeremy","last_name":"Howick","domain_name":"leicester","page_name":"JeremyHowick","display_name":"Jeremy Howick","profile_url":"https://leicester.academia.edu/JeremyHowick?f_ri=87529","photo":"https://0.academia-photos.com/3412352/1169130/1465672/s65_jeremy.howick.jpg"}],"research_interests":[{"id":6482,"name":"Meta-Analysis and Systematic Review","url":"https://www.academia.edu/Documents/in/Meta-Analysis_and_Systematic_Review?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_26328072" data-work_id="26328072" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/26328072/Spanish_Guideline_for_the_management_of_Asthma">Spanish Guideline for the management of Asthma</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/26328072" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="17e16646d0f5ae4413789b5b90ae0521" rel="nofollow" data-download="{"attachment_id":46639503,"asset_id":26328072,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46639503/download_file?st=MTczMjY5OTEyMiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39569493" href="https://independent.academia.edu/AlfonsoDelCuvillo">Alfonso Del Cuvillo</a><script data-card-contents-for-user="39569493" type="text/json">{"id":39569493,"first_name":"Alfonso","last_name":"Del Cuvillo","domain_name":"independent","page_name":"AlfonsoDelCuvillo","display_name":"Alfonso Del Cuvillo","profile_url":"https://independent.academia.edu/AlfonsoDelCuvillo?f_ri=87529","photo":"https://0.academia-photos.com/39569493/10886216/39229978/s65_alfonso.del_cuvillo.png"}</script></span></span></li><li class="js-paper-rank-work_26328072 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="26328072"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 26328072, container: ".js-paper-rank-work_26328072", }); });</script></li><li class="js-percentile-work_26328072 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26328072; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_26328072"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_26328072 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="26328072"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26328072; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26328072]").text(description); $(".js-view-count-work_26328072").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_26328072").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="26328072"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="14911" href="https://www.academia.edu/Documents/in/Asthma_In_Children">Asthma In Children</a>, <script data-card-contents-for-ri="14911" type="text/json">{"id":14911,"name":"Asthma In Children","url":"https://www.academia.edu/Documents/in/Asthma_In_Children?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="20212" href="https://www.academia.edu/Documents/in/Allergic_asthma">Allergic asthma</a>, <script data-card-contents-for-ri="20212" type="text/json">{"id":20212,"name":"Allergic asthma","url":"https://www.academia.edu/Documents/in/Allergic_asthma?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a><script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=26328072]'), work: {"id":26328072,"title":"Spanish Guideline for the management of Asthma","created_at":"2016-06-20T02:29:55.359-07:00","url":"https://www.academia.edu/26328072/Spanish_Guideline_for_the_management_of_Asthma?f_ri=87529","dom_id":"work_26328072","summary":null,"downloadable_attachments":[{"id":46639503,"asset_id":26328072,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39569493,"first_name":"Alfonso","last_name":"Del Cuvillo","domain_name":"independent","page_name":"AlfonsoDelCuvillo","display_name":"Alfonso Del Cuvillo","profile_url":"https://independent.academia.edu/AlfonsoDelCuvillo?f_ri=87529","photo":"https://0.academia-photos.com/39569493/10886216/39229978/s65_alfonso.del_cuvillo.png"}],"research_interests":[{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false},{"id":14911,"name":"Asthma In Children","url":"https://www.academia.edu/Documents/in/Asthma_In_Children?f_ri=87529","nofollow":false},{"id":20212,"name":"Allergic asthma","url":"https://www.academia.edu/Documents/in/Allergic_asthma?f_ri=87529","nofollow":false},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false},{"id":677385,"name":"Nasal Polyposis","url":"https://www.academia.edu/Documents/in/Nasal_Polyposis?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20701082" data-work_id="20701082" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20701082/Allergic_Rhinitis_and_its_Impact_on_Asthma_ARIA_2008_">Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div 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data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4990" href="https://www.academia.edu/Documents/in/Global_Health">Global Health</a>, <script data-card-contents-for-ri="4990" type="text/json">{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20701082]'), work: {"id":20701082,"title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*","created_at":"2016-01-24T07:59:41.513-08:00","url":"https://www.academia.edu/20701082/Allergic_Rhinitis_and_its_Impact_on_Asthma_ARIA_2008_?f_ri=87529","dom_id":"work_20701082","summary":null,"downloadable_attachments":[{"id":41513691,"asset_id":20701082,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32791651,"first_name":"Juan","last_name":"Ivancevich","domain_name":"salvador","page_name":"JIvancevich","display_name":"Juan C 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Mucosa","url":"https://www.academia.edu/Documents/in/Nasal_Mucosa?f_ri=87529"},{"id":1799441,"name":"Rhinitis","url":"https://www.academia.edu/Documents/in/Rhinitis?f_ri=87529"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology?f_ri=87529"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15410512" data-work_id="15410512" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15410512/Prevalence_of_malocclusion_among_mouth_breathing_children_Do_expectations_meet_reality">Prevalence of malocclusion among mouth breathing children: Do expectations meet reality?</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x 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href="https://www.academia.edu/Documents/in/Comorbidity">Comorbidity</a>, <script data-card-contents-for-ri="28973" type="text/json">{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" href="https://www.academia.edu/Documents/in/Child">Child</a>, <script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a>, <script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="120118" href="https://www.academia.edu/Documents/in/Malocclusion">Malocclusion</a><script data-card-contents-for-ri="120118" type="text/json">{"id":120118,"name":"Malocclusion","url":"https://www.academia.edu/Documents/in/Malocclusion?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=15410512]'), work: {"id":15410512,"title":"Prevalence of malocclusion among mouth breathing children: Do expectations meet 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})();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22245578" data-work_id="22245578" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22245578/Glucocorticosteroids_in_Allergic_Inflammation_Clinical_Benefits_in_Allergic_Rhinitis_Rhinosinusitis_and_Otitis_Media">Glucocorticosteroids in Allergic Inflammation: Clinical Benefits in Allergic Rhinitis, Rhinosinusitis, and Otitis Media</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22245578" data-share-source="work_strip" 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href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9334" href="https://www.academia.edu/Documents/in/Inflammation">Inflammation</a>, <script data-card-contents-for-ri="9334" type="text/json">{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a>, <script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="204350" href="https://www.academia.edu/Documents/in/Anti-inflammatory_agents">Anti-inflammatory agents</a><script data-card-contents-for-ri="204350" type="text/json">{"id":204350,"name":"Anti-inflammatory agents","url":"https://www.academia.edu/Documents/in/Anti-inflammatory_agents?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22245578]'), work: {"id":22245578,"title":"Glucocorticosteroids in Allergic Inflammation: Clinical Benefits in Allergic Rhinitis, Rhinosinusitis, and Otitis 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href="https://www.academia.edu/9503498/Homeopathy_in_paediatric_atopic_diseases_long_term_results_in_children_with_atopic_dermatitis">Homeopathy in paediatric atopic diseases: long-term results in children with atopic dermatitis</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/9503498" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="56b189f43a0de3fbf9639bc51755cd97" rel="nofollow" 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$(".js-view-count-work_9503498").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_9503498").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="9503498"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="4083" href="https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine">Complementary and Alternative Medicine</a>, <script data-card-contents-for-ri="4083" type="text/json">{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4085" href="https://www.academia.edu/Documents/in/Homeopathy">Homeopathy</a>, <script data-card-contents-for-ri="4085" type="text/json">{"id":4085,"name":"Homeopathy","url":"https://www.academia.edu/Documents/in/Homeopathy?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="46131" href="https://www.academia.edu/Documents/in/Paediatrics">Paediatrics</a>, <script data-card-contents-for-ri="46131" type="text/json">{"id":46131,"name":"Paediatrics","url":"https://www.academia.edu/Documents/in/Paediatrics?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a><script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new 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class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_29539166" data-work_id="29539166" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/29539166/Pediatric_allergic_rhinitis_and_asthma_can_the_march_be_halted">Pediatric allergic rhinitis and asthma: can the march be halted?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The strong epidemiologic and pathophysiologic link between allergic rhinitis (AR) and asthma has led to the concept of &#39;united airways disease&#39; or &#39;respiratory allergy&#39;, implying that allergy, in its widest sense,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_29539166" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The strong epidemiologic and pathophysiologic link between allergic rhinitis (AR) and asthma has led to the concept of &#39;united airways disease&#39; or &#39;respiratory allergy&#39;, implying that allergy, in its widest sense, underlies this clinical syndrome. Progression from AR to asthma is frequent and part of the &#39;atopic march&#39;. Since pediatric immune responses are more adaptable and therefore may be more amenable to treatment, interventions at early childhood are characterized by a higher chance to affect the natural history of respiratory allergy. Although current treatments are quite effective in alleviating respiratory allergy symptoms, it has proven much more difficult to confirm any influence on the progression of the disease. Much more promising is the field of specific allergen immunotherapy, where current evidence, although not yet of ideal robustness, points towards a disease-modifying effect. In addition, newer or emerging, possibly more effective or more t...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/29539166" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dfa54139a22695fd72d203be4c8101ef" rel="nofollow" data-download="{"attachment_id":49983138,"asset_id":29539166,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49983138/download_file?st=MTczMjY5OTEyMiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33090035" href="https://manchester.academia.edu/NGP">Nikolaos G Papadopoulos</a><script data-card-contents-for-user="33090035" type="text/json">{"id":33090035,"first_name":"Nikolaos","last_name":"Papadopoulos","domain_name":"manchester","page_name":"NGP","display_name":"Nikolaos G Papadopoulos","profile_url":"https://manchester.academia.edu/NGP?f_ri=87529","photo":"https://0.academia-photos.com/33090035/14708015/15532530/s65_nikolaos.papadopoulos.jpg"}</script></span></span></li><li class="js-paper-rank-work_29539166 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="29539166"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 29539166, container: ".js-paper-rank-work_29539166", }); 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$(".js-view-count[data-work-id=29539166]").text(description); $(".js-view-count-work_29539166").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_29539166").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="29539166"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" href="https://www.academia.edu/Documents/in/Child">Child</a>, <script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=87529","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="87529" href="https://www.academia.edu/Documents/in/Allergic_rhinitis">Allergic rhinitis</a><script data-card-contents-for-ri="87529" type="text/json">{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=87529","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=29539166]'), work: {"id":29539166,"title":"Pediatric allergic rhinitis and asthma: can the march be halted?","created_at":"2016-10-30T08:48:49.431-07:00","url":"https://www.academia.edu/29539166/Pediatric_allergic_rhinitis_and_asthma_can_the_march_be_halted?f_ri=87529","dom_id":"work_29539166","summary":"The strong epidemiologic and pathophysiologic link between allergic rhinitis (AR) and asthma has led to the concept of \u0026#39;united airways disease\u0026#39; or \u0026#39;respiratory allergy\u0026#39;, implying that allergy, in its widest sense, underlies this clinical syndrome. Progression from AR to asthma is frequent and part of the \u0026#39;atopic march\u0026#39;. Since pediatric immune responses are more adaptable and therefore may be more amenable to treatment, interventions at early childhood are characterized by a higher chance to affect the natural history of respiratory allergy. Although current treatments are quite effective in alleviating respiratory allergy symptoms, it has proven much more difficult to confirm any influence on the progression of the disease. Much more promising is the field of specific allergen immunotherapy, where current evidence, although not yet of ideal robustness, points towards a disease-modifying effect. 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