Translation of Research to Practice for the Treatment of Opioid Addiction

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aria-label="expand-button"></button> <ul class="menu-level-1 no-bullets"> <li class="menu-item no-bullets nav-list-item-1"> <a href="/resources/engagement" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/43166">Patient and Community Engagement</a> </li> </ul> </li> </ul> </nav> </header> <div data-drupal-messages-fallback class="hidden"></div> <header role="banner"> <div class="background-jumbotron masthead-jumbotron jumbotron jumbotron-fluid pattern" style="background-image:url(/files/RFA-Header_Cancer-Patient-and-Senior-Mother.jpg);" > <div class="container-fluid"> <h1><span>Translation of Research to Practice for the Treatment of Opioid Addiction</span> </h1> <div class="row justify-content-center subtitle"> <div class="col-xl-8 col-lg-8 col-sm-12 col-xs-12"> <p>The NIH HEAL Initiative will deploy a suite of implementation science efforts to test the integration of evidence-based interventions in an array of settings.</p> </div> </div> </div> </div> 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Dream Center </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="the-justice-system-provides-a-window-of-opportunity-to-treat-addiction"> <a href="/news/stories/jcoin-window-opportunity-treat-addiction" aria-label="The Justice System Provides a Window of Opportunity to Treat Addiction"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/ScopeOfTheProblem.jpg?itok=xpTfwxIq" width="900" height="507" alt="The Scope of the Problem: Opioid Use Disorders in Jails" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/jcoin-window-opportunity-treat-addiction"> The Justice System Provides a Window of Opportunity to Treat Addiction </a> </p> </div> </div> </div> </div> </span> </div> <div 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src="/files/styles/callout_carousel/public/emergency-department.jpeg?itok=Ir-egDL4" width="900" height="507" alt="emergency department sign" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/emergency-department-opioid-treatment"> The Emergency Department: Time and Place to Treat </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="breaking-through-the-wall-of-stigma"> <a href="/news/stories/breaking-through-the-wall-on-stigma" aria-label="Breaking Through the Wall of Stigma"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/HEAL_Addressing%20Stigma%20in%20Healthcare%28playbutton%29_resized.jpg?itok=kQwGTfyE" width="900" height="507" alt="addressing stigma" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/breaking-through-the-wall-on-stigma"> Breaking Through the Wall of Stigma </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="about-the-justice-community-opioid-innovation-network"> <a href="/news/stories/QandA-with-Tisha-Wiley" aria-label="About the Justice Community Opioid Innovation Network"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/Zoom%20photo%20of%20JCOIN%20team.jpg?itok=sgc5TnuE" width="900" height="507" alt="Zoom photo of JCOIN team" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/QandA-with-Tisha-Wiley"> About the Justice Community Opioid Innovation Network </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="re-envisioning-how-the-criminal-justice-system-responds-to-the-opioid-crisis"> <a href="/news/stories/about-JCOIN" aria-label="Re-envisioning How the Criminal Justice System Responds to the Opioid Crisis"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/Re-envisioning%20How%20the%20Criminal%20Justice%20System%20Responds%20to%20the%20Opioid%20Crisis.jpg?itok=bH2pYOkQ" width="900" height="507" alt="Image of girl with provider" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/about-JCOIN"> Re-envisioning How the Criminal Justice System Responds to the Opioid Crisis </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="healing-communities-across-america"> <a href="/news/stories/HEALing-Communities" aria-label="HEALing Communities Across America"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/HCS%201%20image%20Naloxone%20Campaign_Palm%20Card_Franklin%20County.jpg?itok=Bg991sYi" width="900" height="507" alt="Communications campaign materials for HCS" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/HEALing-Communities"> HEALing Communities Across America </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="fully-engaged-the-importance-of-involving-patients-in-research"> <a href="/news/stories/importance-of-patient-engagement" aria-label="Fully Engaged: The Importance of Involving Patients in Research"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/Patient%20Engagement.jpg?itok=Fas8erPX" width="900" height="507" alt="Patient Engagement" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/importance-of-patient-engagement"> Fully Engaged: The Importance of Involving Patients in Research </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="mindfulness-a-more-effective-approach-to-pain-and-addiction"> <a href="/news/stories/Mindfulness-Pain-OUD-Recovery" aria-label="Mindfulness: A MORE Effective Approach to Pain and Addiction "> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/MORE%20Mindfulness%20Graphic.jpg?itok=I8CgNrai" width="900" height="507" alt="MORE Mindfulness Graphic" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/Mindfulness-Pain-OUD-Recovery"> Mindfulness: A MORE Effective Approach to Pain and Addiction </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="intervention-for-young-people-aims-to-lift-barriers-to-treatment-for-opioid-use-disorder"> <a href="/news/stories/Youth-Opioid-Recovery" aria-label="Intervention for Young People Aims to Lift Barriers to Treatment for Opioid Use Disorder"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/Stanley%20Moody%2C%20L.P.N..jpg?itok=9mv2NjIi" width="900" height="507" alt="Image of Stanley Moody, L.P.N., administering a medication injection in a van. " class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/Youth-Opioid-Recovery"> Intervention for Young People Aims to Lift Barriers to Treatment for Opioid Use Disorder </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="to-walk-in-the-beauty-way-treating-opioid-use-disorder-in-native-communities"> <a href="/news/stories/native-cultures" aria-label="‘To Walk in the Beauty Way’: Treating Opioid Use Disorder in Native Communities"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/20-0483%20HEAL%20Culture%20MAT%20Feature%20Story%20Graphic_dev4-01%20%28002%29.png?itok=fvnfEVoT" width="900" height="507" alt="Illustration depicting the holistic treatment approach of the researchers' project." class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/native-cultures"> ‘To Walk in the Beauty Way’: Treating Opioid Use Disorder in Native Communities </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="could-a-telehealth-program-improve-outcomes-for-justice-involved-women"> <a href="/news/stories/wjcoin" aria-label="Could a Telehealth Program Improve Outcomes for Justice-Involved Women?"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/wjcoin_cropped%20%28002%29.png?itok=E9N_88CB" width="900" height="507" alt="Three women stand next to each other in front of a fence at a horse farm." class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/wjcoin"> Could a Telehealth Program Improve Outcomes for Justice-Involved Women? </a> </p> </div> </div> </div> </div> </span> </div> <a class="carousel-control-prev" href="#carousel-276810155" role="button" data-slide="prev"> <span class="carousel-control-prev-icon" aria-hidden="true"> <span class="angle-left-icon"></span> </span> <span class="sr-only">Previous</span> </a> <a class="carousel-control-next" href="#carousel-276810155" role="button" data-slide="next"> <span class="carousel-control-next-icon" aria-hidden="true"> <span class="angle-right-icon"></span> </span> </span> <span class="sr-only">Next</span> </a> </div> </div> </div> </div> </div> <p class='col-12'> <h2>Overview</h2> <p>There are multiple effective evidence-based treatments and programs for opioid use disorder. Most Americans at risk for or who have this condition, however, do not receive treatment. At the same time, opioid overdoses are increasingly deadly across the nation. To better understand how promising, evidence-based strategies and treatments might help more people with opioid use disorder, the Helping to End Addiction Long-term<sup>®</sup> Initiative, or NIH HEAL Initiative<sup>®</sup>, supports implementation research to test the integration of evidence-based interventions in various community settings.</p> </p> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-44b43a24bc1ccce65d8cb927ad00505fec9f8721a646c47f711ac09e3a45e110"> <h2>Open Funding Opportunities </h2> <div class="pattern"> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2022 </div> <div class="col-lg-6 col-md-12"> Notice of Special Interest (NOSI) HEAL Initiative: Workforce Interventions to Improve Addiction Care Quality and Patient Outcomes </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=https://grants.nih.gov/grants/guide/notice-files/not-da-23-008.html#> NOFO Link </a> </div> <div class="col-6 d-lg-none"> <a href="https://grants.nih.gov/grants/guide/notice-files/not-da-23-008.html#">NOFO Link</a> </div> <div class="col-6 d-lg-none"> Aug 03, 2022 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2024 </div> <div class="col-lg-6 col-md-12"> HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional) </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-077.html#> NOFO Link </a> </div> <div class="col-6 d-lg-none"> <a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-077.html#">NOFO Link</a> </div> <div class="col-6 d-lg-none"> Dec 17, 2024 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2024 </div> <div class="col-lg-6 col-md-12"> HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional) </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-078.html#> NOFO Link </a> </div> <div class="col-6 d-lg-none"> <a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-078.html#">NOFO Link</a> </div> <div class="col-6 d-lg-none"> Dec 17, 2024 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2022 </div> <div class="col-lg-6 col-md-12"> Notice of Special Interest (NOSI): HEAL Initiative: Opioid Use Disorder Care Pathways for Individuals with Histories of Exposure to Violence </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=https://grants.nih.gov/grants/guide/notice-files/not-da-23-007.html#> NOFO Link </a> </div> <div class="col-6 d-lg-none"> <a href="https://grants.nih.gov/grants/guide/notice-files/not-da-23-007.html#">NOFO Link</a> </div> <div class="col-6 d-lg-none"> Aug 03, 2022 </div> </div> </div> <div style="text-align:right;"> <a class="btn btn-primary" href=/funding/open?rfa=61> View all </a> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> <div class="views-element-container form-group"><div class="js-view-dom-id-f30420ba0ca3c44f9ed447ce3abfa4d8be5f1d8e9e64ec9c476394e61de0839c"> <div class="col-xl-12 col-lg-12 col-md-12 col-sm-12 col-xs-12"> <h2>Research Programs</h2> <div class="views-row"><div><h3><a href="/research/research-to-practice/brim" hreflang="en">Behavioral Research to Improve Medication-Based Treatment</a></h3></div><div class="views-field views-field-field-explainer"><div class="field-content"><p>In collaboration with the Substance Abuse and Mental Health Services Administration, the Behavioral Research to Improve Medication-Based Treatment program is studying whether combining behavioral interventions with medication-based treatment for opioid use disorder improves health outcomes for patients with the condition. Behavioral interventions such as mindfulness meditation, cognitive behavioral therapy, and multidisciplinary rehabilitation are being evaluated as ways to increase adherence to medication-based treatment, reduce relapse, and improve health outcomes.</p></div></div></div> <div class="views-row"><div><h3><a href="/research/research-to-practice/continuum-care-hospitalized-patients-opioid-use-disorder" hreflang="en">The Continuum of Care in Hospitalized Patients with Opioid Use Disorder and Infectious Complications of Drug Use (CHOICE)</a></h3></div><div class="views-field views-field-field-explainer"><div class="field-content"><p>The Continuum of Care in Hospitalized Patients with Opioid Use Disorder and Infectious Complications of Drug Use (CHOICE) program will evaluate patients hospitalized with an infectious complication of injection drug use and identify and understand gaps in care that arise across the continuum of care. The program will develop an informed intervention to eliminate barriers and improve health outcomes in this population.</p></div></div></div> <div class="views-row"><div><h3><a href="/research/research-to-practice/enhancing-clinical-trials-network" hreflang="en">Enhancing the National Drug Abuse Treatment Clinical Trials Network to Address Opioids</a></h3></div><div class="views-field views-field-field-explainer"><div class="field-content"><p>Expansion of the National Drug Abuse Treatment Clinical Trials Network (CTN) is addressing emergent needs presented by the nation’s opioid and overdose crisis. The CTN integrates new opioid-related research questions into clinical studies related to substance use that are currently underway, expedites new studies in general medical and other settings, and enhances clinical and research training opportunities.</p></div></div></div> <div class="views-row"><div><h3><a href="/research/research-to-practice/harm-reduction-approaches-reduce-overdose-deaths" hreflang="en">Harm Reduction Research Network</a></h3></div><div class="views-field views-field-field-explainer"><div class="field-content"><p>In support of the Administration’s focus on harm reduction to prevent or reduce overdose deaths, the Harm Reduction Approaches to Reduce Overdose Deaths program will establish a harm reduction network of research projects. This research will evaluate the effectiveness, implementation, and impact of existing and new harm reduction approaches.</p></div></div></div> <div class="views-row"><div><h3><a href="/research/research-to-practice/healing-communities" hreflang="en">HEALing Communities Study</a></h3></div><div class="views-field views-field-field-explainer"><div class="field-content"><p>The HEALing Communities Study (HCS) was the largest addiction prevention and treatment implementation study ever conducted. Launched in 2019, the HEALing Communities Study is the largest addiction prevention and treatment implementation study ever conducted and took place in 67 communities in Kentucky, Massachusetts, New York, and Ohio – four states that have been hard hit by the opioid crisis. Findings will help establish best practices for integrating prevention and treatment strategies that can be adapted by communities nationwide.</p></div></div></div> <div class="views-row"><div><h3><a href="/research/research-to-practice/delivery-healthcare-services-polysubstance-use" hreflang="en">Improving Delivery of Healthcare Services for Polysubstance Use</a></h3></div><div class="views-field views-field-field-explainer"><div class="field-content"><p>In recent years, the proportion of opioid-related deaths involving co-occurring use of other substances has increased significantly. The Improving Delivery of Healthcare Services for Polysubstance Use program will support research to enhance understanding of why and how polysubstance use occurs and how it can be prevented. By assessing the treatment and recovery needs of people with polysubstance use, this research aims to address how best to meet these needs.</p></div></div></div> <div class="views-row"><div><h3><a href="/research/research-to-practice/jcoin" hreflang="en">Justice Community Overdose Innovation Network (JCOIN)</a></h3></div><div class="views-field views-field-field-explainer"><div class="field-content"><p>The Justice Community Overdose Innovation Network (JCOIN) aims to enhance quality care for opioid misuse and opioid use disorder in criminal justice-involved populations. JCOIN creates partnerships between local and state justice systems and community-based treatment providers. Its research findings are addressing the critical need to improve the quality of opioid use disorder treatment in the U.S. justice system.</p></div></div></div> <div class="views-row"><div><h3><a href="/research/research-to-practice/native-collective-research-effort-enhance-wellness-overdose-substance-mental-health-pain" hreflang="en">Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain </a></h3></div><div class="views-field views-field-field-explainer"><div class="field-content"><p>The Native Collective Research Effort to Enhance Wellness (N CREW) program will co-construct and establish a novel way to partner with Tribes and Native American Serving Organizations to learn, understand, and meet the research needs of Native Americans, in direct response to priorities identified in Tribal Consultations and listening sessions. In partnership with NIH and other organizations, the N CREW program is a multi-component program using a variety of funding mechanisms, which may include Other Transactions, Cooperative Agreements, Contracts, and/or Grants over the course of the program.</p></div></div></div> <div class="views-row"><div><h3><a href="/research/research-to-practice/optimizing-addiction-services" hreflang="en">Optimizing the Quality, Reach, and Impact of Addiction Services</a></h3></div><div class="views-field views-field-field-explainer"><div class="field-content"><p>Interventions to prevent and treat opioid use disorder and overdose are only useful if they work effectively in real-world settings. The Optimizing the Quality, Reach, and Impact of Addiction Services program supports action-oriented projects that accelerate research to practice translation, expanding care access and quality of care for all people with a substance use disorder. The program also includes research to support well-being among health and mental health care providers working with people with substance use disorders.</p></div></div></div> <div class="views-row"><div><h3><a href="/research/research-to-practice/research-recovery-network" hreflang="en">Recovery Research Networks</a></h3></div><div class="views-field views-field-field-explainer"><div class="field-content"><p>The Recovery Research Networks program focuses on developing multi-stakeholder networks (researchers, payors, providers, people in recovery) to support the development of infrastructure to advance the science of long-term recovery. Five projects form the Consortium on Addiction Recovery Science (CoARS). Collectively, these projects are developing resources to support recovery research centered around community-based recovery centers, justice-involved youth, family-based recovery, recovery in rural settings, and integrated networks of care.</p></div></div></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </main> <div class="container"> <p class="last-updated">Page last updated August 22, 2024</p> </div> </div> </div> <footer class="fluid-container p-3 footer" role="contentinfo"> <div class="container"> <div class="row"> <div class="col-12 col-md-3"> <div class="footer-logo"><a href="/"><img alt="NIH HEAL Initiative" src="/assets/HEAL_Initaitive_White.svg" /></a></div> <h2>Contact Us</h2> <p>Please send email to <a href="/cdn-cgi/l/email-protection#6b232e2a271a1e0e181f0204052b040f45050203450c041d"><span class="__cf_email__" data-cfemail="e1a9a4a0ad9094849295888e8fa18e85cf8f8889cf868e97">[email protected]</span></a></p> </div> <div class="col-6 col-md-3"> 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Translation of Research to Practice for the Treatment of Opioid Addiction | NIH HEAL Initiative