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Enhancing the National Drug Abuse Treatment Clinical Trials Network to Address Opioids | NIH HEAL Initiative
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href="/resources/engagement" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/43166">Patient and Community Engagement</a> </li> </ul> </li> </ul> </nav> </header> <div data-drupal-messages-fallback class="hidden"></div> <div class="color-gradient"></div> <main role="main"> <div class="container"> <a id="main-content" tabindex="-1"></a> <div class="row"> <div class="col-sm-12 breadcrumb-col col-md-7"> <div id="block-particle-breadcrumbs"> <nav aria-label="breadcrumb" role="navigation"> <ol class="breadcrumb"> <li class="breadcrumb-item gtm-breadcrumb"><a href="/" class="gtm-breadcrumb">Home</a></li> <li class="breadcrumb-item gtm-breadcrumb"><a href="/research" class="gtm-breadcrumb">Research</a></li> <li class="breadcrumb-item gtm-breadcrumb"><a href="/research/research-to-practice" class="gtm-breadcrumb">Translation of Research To Practice For The Treatment of Opioid Addiction</a></li> <li class="breadcrumb-item active is-active gtm-breadcrumb" aria-current="page">Enhancing the National Drug Abuse Treatment Clinical Trials Network to Address Opioids</li> </ol> </nav> </div> </div> <div class="col-sm-12 col-md-5"> </div> </div> </div> <div class="layout-content"> <div> <div id="block-particle-content"> <h1> Enhancing the National Drug Abuse Treatment Clinical Trials Network to Address Opioids </h1> <div> <div class="paragraph paragraph--type--content-and-view paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div class='row'> <div> <div class="col-12 col-xl-6 float-right"> <div class="views-element-container form-group"><div class="carousel-view js-view-dom-id-ae849e1428543eebf55eef7dc42a01ee3e0e07517a6398da66997bf09fdd85ce"> <div id="carousel-168396152" class="callout carousel slide" data-ride="carousel"> <button type=button class="btn carousel-pause" target="" > <span class="pause-icon"></span> </button> <button type=button class="btn carousel-play" target="" > <span class="play-icon"></span> </button> <ol class="carousel-indicators"> <li data-target="#carousel-168396152" data-slide-to="0" class="active"></li> <li data-target="#carousel-168396152" data-slide-to="1" class=""></li> <li data-target="#carousel-168396152" data-slide-to="2" class=""></li> <li data-target="#carousel-168396152" data-slide-to="3" class=""></li> </ol> <div class="carousel-inner"> <p><strong>Research Spotlights</strong></p> <div class="carousel-item active"> <span class="carousel-item-container"> <div class="card overlay-body" id="can-telemedicine-address-the-opioid-crisis-in-rural-america"> <a href="/news/stories/rural-telemedicine" aria-label="Can Telemedicine Address the Opioid Crisis in Rural America?"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/Rural%20Telemedicine%20Spotlight.jpeg?itok=DbmpyFxu" width="900" height="507" alt="Person waving hello to their health care provider via a telemedicine visit" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/rural-telemedicine"> Can Telemedicine Address the Opioid Crisis in Rural America? </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="video-better-together-with-the-dc-dream-center"> <a href="/news/stories/video-better-together" aria-label="Video: Better Together With the D.C. Dream Center"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/schottenfeld-video.JPG?itok=wuo82Mly" width="900" height="507" alt="Richard Schottenfeld" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/video-better-together"> Video: Better Together With the D.C. Dream Center </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="the-emergency-department-time-and-place-to-treat"> <a href="/news/stories/emergency-department-opioid-treatment" aria-label="The Emergency Department: Time and Place to Treat"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/emergency-department.jpeg?itok=Ir-egDL4" width="900" height="507" alt="emergency department sign" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/emergency-department-opioid-treatment"> The Emergency Department: Time and Place to Treat </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="breaking-through-the-wall-of-stigma"> <a href="/news/stories/breaking-through-the-wall-on-stigma" aria-label="Breaking Through the Wall of Stigma"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/HEAL_Addressing%20Stigma%20in%20Healthcare%28playbutton%29_resized.jpg?itok=kQwGTfyE" width="900" height="507" alt="addressing stigma" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/breaking-through-the-wall-on-stigma"> Breaking Through the Wall of Stigma </a> </p> </div> </div> </div> </div> </span> </div> <a class="carousel-control-prev" href="#carousel-168396152" role="button" data-slide="prev"> <span class="carousel-control-prev-icon" aria-hidden="true"> <span class="angle-left-icon"></span> </span> <span class="sr-only">Previous</span> </a> <a class="carousel-control-next" href="#carousel-168396152" role="button" data-slide="next"> <span class="carousel-control-next-icon" aria-hidden="true"> <span class="angle-right-icon"></span> </span> </span> <span class="sr-only">Next</span> </a> </div> </div> </div> </div> </div> <p class='col-12'> <h2>Overview</h2> <h3>The Research Need</h3> <p>The National Drug Abuse Treatment Clinical Trials Network (CTN) was established in 1999 to bridge the gap between research and practice to improve treatment of substance use disorders. It supports rigorous multisite clinical trials to determine the effectiveness of treatment and prevention strategies in a broad range of treatment settings and patient populations. The CTN is organized into multiple nodes located in areas of the country most affected by the opioid crisis and linked by central coordinating centers. Each node conducts research in collaboration with treatment sites that represent the continuum of care for people with substance use disorders.</p> <h3>About the Program</h3> <p>The CTN facilitates collaboration among researchers, medical and treatment providers, patients, and NIH staff to develop, test, and implement new addiction treatments. It expands research into settings that are significantly affected by the opioid crisis but often left out of research projects.</p> <p>In 2019, the Helping to End Addiction Long-term<sup>®</sup> Initiative, or NIH HEAL Initiative<sup>®</sup>, expanded the CTN by funding five additional nodes, strengthening the network by expanding existing studies and starting new research in new locations and settings hit hard by the opioid crisis.</p> <ul> <li>The <strong>Appalachian Node</strong> is a collaboration between the <a>University of Pittsburgh and West Virginia University</a>.</li> <li>The <strong>Great Lakes Node</strong> is based at the <a>University of Illinois Chicago</a>.</li> <li>The <strong>Greater Intermountain Node</strong> is based at the <a>University of Utah</a>.</li> <li>The <strong>Greater Southern California Node</strong> is based at the <a>University of California, Los Angeles</a>.</li> <li>The <strong>Southwest Node</strong> is based at the <a>University of New Mexico</a>.</li> </ul> <p>Through these additional nodes, the program is strengthening the CTN’s ability to develop and implement new studies for improving access to high-quality addiction treatment—for example, in general medical settings rather than specialized treatment settings. It is also creating new opportunities for clinical and research training.</p> <p>See a list of HEAL-funded CTN protocols on <a href="https://nida.nih.gov/about-nida/organization/cctn/ctn/research-studies">the National Institute on Drug Abuse website.</a></p> </p> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-fa55d1561a0c8d08209dfe5abdb754ab5936b816c900c1f116eeea9ba10b76c7"> <h2>Open Funding Opportunities</h2> <div class="pattern"> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2022 </div> <div class="col-lg-6 col-md-12"> HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K01 - Clinical Trial Required) </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=https://grants.nih.gov/grants/guide/pa-files/PAS-22-206.html> NOFO Link </a> </div> <div class="col-6 d-lg-none"> Jul 14, 2022 </div> <div class="col-6 d-lg-none"> <a href="https://grants.nih.gov/grants/guide/pa-files/PAS-22-206.html">NOFO Link</a> </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2022 </div> <div class="col-lg-6 col-md-12"> HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K23 - Clinical Trial Required) </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=https://grants.nih.gov/grants/guide/pa-files/PAS-22-207.html> NOFO Link </a> </div> <div class="col-6 d-lg-none"> Jul 14, 2022 </div> <div class="col-6 d-lg-none"> <a href="https://grants.nih.gov/grants/guide/pa-files/PAS-22-207.html">NOFO Link</a> </div> </div> </div> <div style="text-align:right;"> <a class="btn btn-primary" target="" href=/funding/open?research_program=96> View all </a> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> Program Details </h2> <div class="basic-content-grid-no-media"> <div> <p>To date, through the Helping to End Addiction Long-term Initiative, or NIH HEAL Initiative, NIH has contributed $190.3 million through five awards to establish new CTN nodes:</p> <ul> <li>Appalachian Node</li> <li>Great Lakes Node</li> <li>Greater Intermountain Node</li> <li>Greater Southern California Node</li> <li>Southwest Node</li> </ul> <p>Additional grants were awarded to further expand the CTN’s opioid use disorder research investment through 24 new studies.</p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> Research Examples </h2> <div class="basic-content-grid-no-media"> <div> <p>Research projects being carried out through the CTN include: </p> <ul> <li>Evaluating interventions to prevent people who misuse opioids but do not meet criteria for opioid use disorder from developing moderate or severe opioid use disorder</li> <li>Comparing two types of medication therapy with buprenorphine for pregnant women with opioid use disorder in real-world settings</li> <li>Studying the feasibility of various strategies for initiation of buprenorphine therapy and referral to long-term treatment for patients with opioid use disorder treated in emergency department settings</li> <li>Assessing the effectiveness of monthly buprenorphine injections for treatment of methamphetamine use disorder</li> <li>Evaluating the feasibility and effectiveness of collaborative care for treating patients with polysubstance use in primary care settings</li> </ul> <p><a href="https://www.nida.nih.gov/about-nida/organization/cctn/ctn/research-studies">Find information about other CTN studies, including those supported by the NIH HEAL Initiative.</a></p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--accordion paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div id="accordion-310377419" class="col-12 accordion"> <div class="card-header col-12" id="heading-310377419-0"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-310377419-0" aria-expanded="false" aria-controls="collapse-310377419-0"> Funded Institutions and Locations </button> </h2> </div> <div id="collapse-310377419-0" class="collapse " aria-labelledby="heading-310377419-0" data-parent="#accordion-310377419"> <div class="card-body"> <h3>New CTN Nodes</h3> <ul> <li><strong>Appalachian Node</strong> – University of Pittsburgh and West Virginia University</li> <li><strong>Great Lakes Node</strong> – University of Illinois Chicago</li> <li><strong>Greater Intermountain Node</strong> – University of Utah</li> <li><strong>Greater Southern California Node</strong> – University of California, Los Angeles</li> <li><strong>Southwest Node</strong> – University of New Mexico</li> </ul> <h3>Existing CTN Nodes</h3> <ul> <li><strong>Big South-West Node </strong>– University of Texas Southwestern Medical Center at Dallas, University of Texas Health Science Center at San Antonio California, Los Angeles, and University of Texas, San Antonio, and University of California, Los Angeles</li> <li><strong>Florida Node Alliance Node </strong>– University of Miami and Columbia University</li> <li><strong>Health Systems </strong>Node – Kaiser Foundation Research Institute</li> <li><strong>New England Consortium</strong> – Yale University and McLean Hospital/Harvard Medical School</li> <li><strong>New York Node</strong> – New York University & Columbia University/New York State Psychiatric Institute</li> <li><strong>Northeast Node</strong> – Dartmouth College</li> <li><strong>Northstar Node</strong> – Minneapolis Medical Research Foundation</li> <li><strong>Ohio Valley Node</strong> – University of Cincinnati</li> <li><strong>Pacific Northwest Node</strong> – University of Washington and Washington State University</li> <li><strong>Southern Consortium Node</strong> – Medical University of South Carolina</li> <li><strong>Western States Node</strong> – Oregon Health & Science University and Stanford University</li> </ul> <h3>Coordinating Centers</h3> <ul> <li><strong>Clinical Coordinating Center</strong> – The Emmes Corporation (Maryland)</li> <li><strong>Data & Statistics Center</strong> – The Emmes Corporation (Maryland)</li> </ul> </div> </div> </div> <div id="accordion-1791641892" class="col-12 accordion"> <div class="card-header col-12" id="heading-1791641892-1"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-1791641892-1" aria-expanded="false" aria-controls="collapse-1791641892-1"> Funded Projects </button> </h2> </div> <div id="collapse-1791641892-1" class="collapse " aria-labelledby="heading-1791641892-1" data-parent="#accordion-1791641892"> <div class="card-body"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-392a490c46441bf8131574e7ded0c2523ce95eb1872ef7e4f993c0f8cfd70154"> <div class="pattern"> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2024 </div> <div class="col-lg-6 col-md-12"> EMS initiated Buprenorphine for Opioid Use Disorder </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=96#project-title-47646> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=96#project-title-47646">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 05, 2024 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2024 </div> <div class="col-lg-6 col-md-12"> CTN - Evaluation of SeMaglutide as an Adjunct to buprenorphine treatment for the treatment of opioid use disorder: A pragmatic Randomized placebo-controlled Trial (SMART) </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=96#project-title-47636> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=96#project-title-47636">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 05, 2024 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2024 </div> <div class="col-lg-6 col-md-12"> Low-threshold buprenorphine treatment at syringe services programs: a Type I hybrid effectiveness-implementation trial” (CTN concept under development) </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=96#project-title-47651> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=96#project-title-47651">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 05, 2024 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2024 </div> <div class="col-lg-6 col-md-12"> CTN - Effects of semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro and Zepbound) on incidence and outcomes of stimulant use disorders and opioid use disorder in real-world populations: target tr </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=96#project-title-47641> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=96#project-title-47641">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 05, 2024 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2021 </div> <div class="col-lg-6 col-md-12"> HEAL Diversity Supplement: Great Lakes Nodes Clinical Trials Network </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=96#project-title-40101> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=96#project-title-40101">Summary</a> </div> <div class="col-6 d-lg-none"> Oct 12, 2021 </div> </div> </div> <div style="text-align:right;"> <a class="btn btn-primary" target="" href=/funding/awarded?research_program=96> View all </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> Participating NIH Institutes, Centers, and Offices </h2> <div class="basic-content-grid-no-media"> <div> <ul> <li><a href="https://www.nida.nih.gov/">National Institute on Drug Abuse (NIDA)</a></li> </ul> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--gradient-card paragraph--view-mode--default"> <div class='container'> <div class='pattern'> <div class="content-card-grid"> <div class="row"> <div class="col-md-4 order-1"> <div class='card gradient'> <div class='card-body'> <h3 class='card-title'> Contact </h3> <div class='card-text'> <p><a href="/cdn-cgi/l/email-protection#7113051018311f1815105f1f18195f161e07">Betty Tai, Ph.D.</a><br /> NIDA</p> </div> </div> </div> </div> <div class="col-md-8 order-2"> <h3>Resources</h3> <p><ul> <li><a href="https://www.nida.nih.gov/about-nida/organization/cctn/clinical-trials-network-ctn">National Drug Abuse Treatment CTN</a></li> <li><a href="https://www.nida.nih.gov/about-nida/organization/cctn/ctn/research-studies">CTN Research Studies</a></li> </ul> </p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> View Other Research Programs in This Focus Area </h2> <div class="basic-content-grid-no-media"> <div> <ul> <li><a href="https://heal.nih.gov/research/research-to-practice/brim">Behavioral Research to Improve Medication-Based Treatment (BRIM)</a></li> <li><a href="https://heal.nih.gov/research/research-to-practice/harm-reduction-approaches-reduce-overdose-deaths">Harm Reduction Approaches to Reduce Overdose Death</a></li> <li><a href="https://heal.nih.gov/research/research-to-practice/healing-communities">HEALing Communities Study</a></li> <li><a href="https://heal.nih.gov/research/research-to-practice/delivery-healthcare-services-polysubstance-use">Improving Delivery of Healthcare Services for Polysubstance Use</a></li> <li><a href="https://heal.nih.gov/research/research-to-practice/jcoin">Justice Community Opioid Innovation Network (JCOIN)</a></li> <li><a href="https://heal.nih.gov/research/research-to-practice/native-collective-research-effort-enhance-wellness-overdose-substance-mental-health-pain">Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain</a></li> <li><a href="https://heal.nih.gov/research/research-to-practice/optimizing-addiction-services" hreflang="en">Optimizing the Quality, Reach, and Impact of Addiction Services</a></li> <li><a href="https://heal.nih.gov/research/research-to-practice/research-recovery-network">Recovery Research Networks</a></li> <li><a href="https://heal.nih.gov/research/research-to-practice/continuum-care-hospitalized-patients-opioid-use-disorder">The Continuum of Care in Hospitalized Patients with Opioid Use Disorder and Infectious Complications of Drug Use (CHOICE)</a></li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </main> <div class="container"> <p class="last-updated">Page last updated August 20, 2024</p> </div> </div> </div> <footer class="fluid-container p-3 footer" role="contentinfo"> <div class="container"> <div class="row"> <div class="col-12 col-md-3"> <div class="footer-logo"><a href="/"><img alt="NIH HEAL Initiative" src="/assets/HEAL_Initaitive_White.svg" /></a></div> <h2>Contact Us</h2> <p>Please send email to <a href="/cdn-cgi/l/email-protection#6e262b2f221f1b0b1d1a0701002e010a4000070640090118"><span class="__cf_email__" data-cfemail="78303d3934090d1d0b0c11171638171c56161110561f170e">[email protected]</span></a></p> </div> <div class="col-6 col-md-3"> <h2><a 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