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Mesonephric duct - Wikipedia

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Available in 19 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-19" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">19 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-af mw-list-item"><a href="https://af.wikipedia.org/wiki/Wolffbuis" title="Wolffbuis – Afrikaans" lang="af" hreflang="af" data-title="Wolffbuis" data-language-autonym="Afrikaans" data-language-local-name="Afrikaans" class="interlanguage-link-target"><span>Afrikaans</span></a></li><li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%82%D9%86%D8%A7%D8%A9_%D8%A7%D9%84%D9%83%D9%84%D9%88%D8%A9_%D8%A7%D9%84%D8%AC%D9%86%D9%8A%D9%86%D9%8A%D8%A9_%D8%A7%D9%84%D9%85%D9%88%D8%B3%D8%B7%D8%A9" title="قناة الكلوة الجنينية الموسطة – Arabic" lang="ar" hreflang="ar" data-title="قناة الكلوة الجنينية الموسطة" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%89%E0%A6%B2%E0%A6%AB%E0%A6%BF%E0%A6%AF%E0%A6%BC%E0%A6%BE%E0%A6%A8_%E0%A6%AC%E0%A6%BE%E0%A6%B9%E0%A6%BF%E0%A6%95%E0%A6%BE" title="উলফিয়ান বাহিকা – Bangla" lang="bn" hreflang="bn" data-title="উলফিয়ান বাহিকা" data-language-autonym="বাংলা" data-language-local-name="Bangla" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Mezonefri%C4%8Dki_kanal" title="Mezonefrički kanal – Bosnian" lang="bs" hreflang="bs" data-title="Mezonefrički kanal" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Wolff%C5%AFv_v%C3%BDvod" title="Wolffův vývod – Czech" lang="cs" hreflang="cs" data-title="Wolffův vývod" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Urnierengang" title="Urnierengang – German" lang="de" hreflang="de" data-title="Urnierengang" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Esmasneerutoruke" title="Esmasneerutoruke – Estonian" lang="et" hreflang="et" data-title="Esmasneerutoruke" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Conducto_de_Wolff" title="Conducto de Wolff – Spanish" lang="es" hreflang="es" data-title="Conducto de Wolff" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Wolffen_hodi" title="Wolffen hodi – Basque" lang="eu" hreflang="eu" data-title="Wolffen hodi" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Canal_de_Wolff" title="Canal de Wolff – French" lang="fr" hreflang="fr" data-title="Canal de Wolff" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Dotto_di_Wolff" title="Dotto di Wolff – Italian" lang="it" hreflang="it" data-title="Dotto di Wolff" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ky mw-list-item"><a href="https://ky.wikipedia.org/wiki/%D0%92%D0%BE%D0%BB%D1%8C%D1%84_%D0%BA%D0%B0%D0%BD%D0%B0%D0%BB%D1%8B" title="Вольф каналы – Kyrgyz" lang="ky" hreflang="ky" data-title="Вольф каналы" data-language-autonym="Кыргызча" data-language-local-name="Kyrgyz" class="interlanguage-link-target"><span>Кыргызча</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Gang_van_Wolff" title="Gang van Wolff – Dutch" lang="nl" hreflang="nl" data-title="Gang van Wolff" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E4%B8%AD%E8%85%8E%E7%AE%A1" title="中腎管 – Japanese" lang="ja" hreflang="ja" data-title="中腎管" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Przewody_Wolffa" title="Przewody Wolffa – Polish" lang="pl" hreflang="pl" data-title="Przewody Wolffa" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Ducto_de_Wolff" title="Ducto de Wolff – Portuguese" lang="pt" hreflang="pt" data-title="Ducto de Wolff" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%92%D0%BE%D0%BB%D1%8C%D1%84%D0%BE%D0%B2_%D0%BA%D0%B0%D0%BD%D0%B0%D0%BB" title="Вольфов канал – Russian" lang="ru" hreflang="ru" data-title="Вольфов канал" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-tl mw-list-item"><a href="https://tl.wikipedia.org/wiki/Maliit_na_tubong_Wolffian" title="Maliit na tubong Wolffian – Tagalog" lang="tl" hreflang="tl" data-title="Maliit na tubong Wolffian" data-language-autonym="Tagalog" data-language-local-name="Tagalog" class="interlanguage-link-target"><span>Tagalog</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%92%D0%BE%D0%BB%D1%8C%D1%84%D1%96%D0%B2_%D0%BA%D0%B0%D0%BD%D0%B0%D0%BB" title="Вольфів канал – Ukrainian" lang="uk" hreflang="uk" data-title="Вольфів канал" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q583232#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" 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.mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above" style="background-color:thistle">Mesonephric duct</th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Gray1109.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Gray1109.png/250px-Gray1109.png" decoding="async" width="250" height="264" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Gray1109.png/375px-Gray1109.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Gray1109.png/500px-Gray1109.png 2x" data-file-width="745" data-file-height="787" /></a></span><div class="infobox-caption"><a href="/wiki/Urogenital_sinus" title="Urogenital sinus">Urogenital sinus</a> of female human <a href="/wiki/Embryo" title="Embryo">embryo</a> of eight and a half to nine weeks old</div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #efefef">Details</th></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Carnegie_stages" title="Carnegie stages">Carnegie stage</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="http://genex.hgu.mrc.ac.uk/Databases/HumanAnatomy/new/carnegie11.shtml">11</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em">Days</th><td class="infobox-data">28</td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Embryology" title="Embryology">Precursor</a></th><td class="infobox-data"><a href="/wiki/Intermediate_mesoderm" title="Intermediate mesoderm">Intermediate mesoderm</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Embryology" title="Embryology">Gives rise to</a></th><td class="infobox-data"><a href="/wiki/Vas_deferens" title="Vas deferens">Vasa deferentia</a>, <a href="/wiki/Seminal_vesicles" title="Seminal vesicles">seminal vesicles</a>, <a href="/wiki/Epididymis" title="Epididymis">epididymides</a>, <a href="/wiki/Gartner%27s_duct" title="Gartner&#39;s duct">Gartner's duct</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #efefef">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Latin" title="Latin">Latin</a></th><td class="infobox-data"><i>ductus mesonephricus; ductus Wolffi</i></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D014928">D014928</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Terminologia_Embryologica" title="Terminologia Embryologica">TE</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://ifaa.unifr.ch/Public/EntryPage/THE/TE2010V1.pdf#page=64?note=Linked_from_Mesonephric">duct_by_E5.6.2.0.0.0.4 E5.6.2.0.0.0.4 </a></td></tr><tr><td colspan="2" class="infobox-below"><a href="/wiki/Anatomical_terminology" title="Anatomical terminology">Anatomical terminology</a><div style="text-align: right;"><small class="noprint">&#91;<a href="https://www.wikidata.org/wiki/Q583232" class="extiw" title="d:Q583232">edit on Wikidata</a>]</small></div></td></tr></tbody></table> <p>The <b>mesonephric duct</b>, also known as the <b>Wolffian duct</b>, <b>archinephric duct</b>, <b>Leydig's duct</b> or <b>nephric duct</b>, is a paired <a href="/wiki/Organ_(anatomy)" class="mw-redirect" title="Organ (anatomy)">organ</a> that develops in the early stages of <a href="/wiki/Embryonic_development" class="mw-redirect" title="Embryonic development">embryonic development</a> in humans and other mammals. It is an important structure that plays a critical role in the formation of <a href="/wiki/Male_reproductive_organs" class="mw-redirect" title="Male reproductive organs">male reproductive organs</a>. The duct is named after <a href="/wiki/Caspar_Friedrich_Wolff" title="Caspar Friedrich Wolff">Caspar Friedrich Wolff</a>, a German <a href="/wiki/Physiologist" class="mw-redirect" title="Physiologist">physiologist</a> and <a href="/wiki/Embryologist" class="mw-redirect" title="Embryologist">embryologist</a> who first described it in 1759.<sup id="cite_ref-auto_1-0" class="reference"><a href="#cite_note-auto-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> </p><p>During embryonic development, the mesonephric ducts form as a part of the <a href="/wiki/Urogenital_system" class="mw-redirect" title="Urogenital system">urogenital system</a>.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mesonephric_duct&amp;action=edit&amp;section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The mesonephric duct connects the primitive kidney, the <i><a href="/wiki/Mesonephros" title="Mesonephros">mesonephros</a></i>, to the <a href="/wiki/Cloaca_(embryology)" title="Cloaca (embryology)">cloaca</a>. It also serves as the <a href="/wiki/Primordium" title="Primordium">primordium</a> for male <a href="/wiki/Urogenital" class="mw-redirect" title="Urogenital">urogenital</a> structures including the <a href="/wiki/Epididymis" title="Epididymis">epididymides</a>, <a href="/wiki/Vas_deferens" title="Vas deferens">vasa deferentia</a>, and <a href="/wiki/Seminal_vesicle" class="mw-redirect" title="Seminal vesicle">seminal vesicles</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Development">Development</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mesonephric_duct&amp;action=edit&amp;section=2" title="Edit section: Development"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In both males and females, the mesonephric ducts develop into the <a href="/wiki/Trigone_of_urinary_bladder" class="mw-redirect" title="Trigone of urinary bladder">trigone of urinary bladder</a>, a part of the bladder wall, but the sexes differentiate in other ways during development of the <a href="/wiki/Development_of_the_urinary_system" title="Development of the urinary system">urinary</a> and <a href="/wiki/Development_of_the_reproductive_system" title="Development of the reproductive system">reproductive</a> organs. </p> <div class="mw-heading mw-heading3"><h3 id="Male">Male</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mesonephric_duct&amp;action=edit&amp;section=3" title="Edit section: Male"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In a <a href="/wiki/Male" title="Male">male</a>, they develop into a system of connected organs between the <a href="/wiki/Efferent_ducts" title="Efferent ducts">efferent ducts</a> of the <a href="/wiki/Testis" class="mw-redirect" title="Testis">testis</a> and the prostate, namely the <a href="/wiki/Epididymis" title="Epididymis">epididymis</a>, the <a href="/wiki/Vas_deferens" title="Vas deferens">vas deferens</a>, and the <a href="/wiki/Seminal_vesicle" class="mw-redirect" title="Seminal vesicle">seminal vesicle</a>. The <a href="/wiki/Prostate" title="Prostate">prostate</a> forms from the <a href="/wiki/Urogenital_sinus" title="Urogenital sinus">urogenital sinus</a> and the efferent ducts form from the <a href="/wiki/Mesonephric_tubules" title="Mesonephric tubules">mesonephric tubules</a>. </p><p>For this, it is critical that the ducts are exposed to <a href="/wiki/Testosterone" title="Testosterone">testosterone</a> during <a href="/wiki/Embryogenesis" class="mw-redirect" title="Embryogenesis">embryogenesis</a>. Testosterone binds to and activates <a href="/wiki/Androgen_receptor" title="Androgen receptor">androgen receptor</a>, affecting intracellular signals and modifying the expression of numerous genes.<sup id="cite_ref-pmid16567946_3-0" class="reference"><a href="#cite_note-pmid16567946-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> </p><p>In the mature male, the function of this system is to store and mature <a href="/wiki/Spermatozoon" title="Spermatozoon">sperm</a>, and provide accessory <a href="/wiki/Semen" title="Semen">semen</a> fluid. </p> <div class="mw-heading mw-heading3"><h3 id="Female">Female</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mesonephric_duct&amp;action=edit&amp;section=4" title="Edit section: Female"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In the <a href="/wiki/Female" title="Female">female</a>, with the absence of <a href="/wiki/Anti-M%C3%BCllerian_hormone" title="Anti-Müllerian hormone">anti-Müllerian hormone</a> secretion by the <a href="/wiki/Sertoli_cells" class="mw-redirect" title="Sertoli cells">Sertoli cells</a> and subsequent Müllerian <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a>, the mesonephric ducts regress, although inclusions may persist. The vestigial <a href="/wiki/Epoophoron" title="Epoophoron">epoophoron</a> arises from these ducts. Also, lateral to the wall of the vagina, a <a href="/wiki/Gartner%27s_duct" title="Gartner&#39;s duct">Gartner's duct</a> could develop as a remnant. </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mesonephric_duct&amp;action=edit&amp;section=5" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Sexual_differentiation">Sexual differentiation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mesonephric_duct&amp;action=edit&amp;section=6" title="Edit section: Sexual differentiation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Sexual_differentiation" title="Sexual differentiation">Sexual differentiation</a></div> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mesonephric_duct&amp;action=edit&amp;section=7" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>It is named after <a href="/wiki/Caspar_Friedrich_Wolff" title="Caspar Friedrich Wolff">Caspar Friedrich Wolff</a> who described the <a href="/wiki/Mesonephros" title="Mesonephros">mesonephros</a> and its ducts in his <a href="/wiki/Dissertation" class="mw-redirect" title="Dissertation">dissertation</a> in 1759.<sup id="cite_ref-auto_1-1" class="reference"><a href="#cite_note-auto-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Additional_images">Additional images</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mesonephric_duct&amp;action=edit&amp;section=8" title="Edit section: Additional images"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size mw-halign-center" typeof="mw:File/Thumb"><a href="/wiki/File:A_laboratory_manual_for_comparative_vertebrate_anatomy_(1922)_(20754316592).jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/A_laboratory_manual_for_comparative_vertebrate_anatomy_%281922%29_%2820754316592%29.jpg/660px-A_laboratory_manual_for_comparative_vertebrate_anatomy_%281922%29_%2820754316592%29.jpg" decoding="async" width="660" height="194" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/A_laboratory_manual_for_comparative_vertebrate_anatomy_%281922%29_%2820754316592%29.jpg/990px-A_laboratory_manual_for_comparative_vertebrate_anatomy_%281922%29_%2820754316592%29.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7f/A_laboratory_manual_for_comparative_vertebrate_anatomy_%281922%29_%2820754316592%29.jpg/1320px-A_laboratory_manual_for_comparative_vertebrate_anatomy_%281922%29_%2820754316592%29.jpg 2x" data-file-width="1408" data-file-height="414" /></a><figcaption>Diagrams to illustrate the changes in the <a href="/wiki/Cloaca_(embryology)" title="Cloaca (embryology)">cloaca</a> in <a href="/wiki/Mammal" title="Mammal">mammals</a> during development. <b>A</b>, early embryonic stage, showing the cloaca receiving the urinary bladder, the rectum, and the Wolffian duct, as in the lower vertebrates. <b>B</b>, later stage, showing the beginning of the fold which divides the cloaca into a ventral <a href="/wiki/Urogenital_sinus" title="Urogenital sinus">urogenital sinus</a> which receives the <a href="/wiki/Urinary_bladder" class="mw-redirect" title="Urinary bladder">urinary bladder</a>, Wolffian ducts, and <a href="/wiki/Ureter" title="Ureter">ureters</a>, and into a dorsal part which receives the <a href="/wiki/Rectum" title="Rectum">rectum</a>. <b>C</b>, further progress of the fold, dividing the cloaca into urogenital sinus and rectum; the ureter has separated from the Wolffian duct and is shifting anteriorly. <b>D</b>, completion of the fold, showing complete separation of the cloaca into ventral urogenital sinus and dorsal rectum.</figcaption></figure> <div style="clear:both;" class=""></div> <ul class="gallery mw-gallery-traditional"> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:Gray29.png" class="mw-file-description" title="Diagram of a transverse section, showing the mode of formation of the amnion in the chick"><img alt="Diagram of a transverse section, showing the mode of formation of the amnion in the chick" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Gray29.png/180px-Gray29.png" decoding="async" width="180" height="110" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Gray29.png/270px-Gray29.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Gray29.png/360px-Gray29.png 2x" data-file-width="500" data-file-height="306" /></a></span></div> <div class="gallerytext">Diagram of a transverse section, showing the mode of formation of the amnion in the chick</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:Gray986.png" class="mw-file-description" title="Reconstruction of a human embryo of 17&#160;mm"><img alt="Reconstruction of a human embryo of 17&#160;mm" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ad/Gray986.png/112px-Gray986.png" decoding="async" width="112" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ad/Gray986.png/168px-Gray986.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ad/Gray986.png/224px-Gray986.png 2x" data-file-width="500" data-file-height="536" /></a></span></div> <div class="gallerytext">Reconstruction of a human embryo of 17&#160;mm</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:Gray992.png" class="mw-file-description" title="Cloaca of human embryo from twenty-five to twenty-seven days old"><img alt="Cloaca of human embryo from twenty-five to twenty-seven days old" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Gray992.png/118px-Gray992.png" decoding="async" width="118" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Gray992.png/176px-Gray992.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Gray992.png/235px-Gray992.png 2x" data-file-width="814" data-file-height="831" /></a></span></div> <div class="gallerytext">Cloaca of human embryo from twenty-five to twenty-seven days old</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:Gray1116.png" class="mw-file-description" title="Tail end of human embryo thirty-two to thirty-three days old"><img alt="Tail end of human embryo thirty-two to thirty-three days old" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a6/Gray1116.png/163px-Gray1116.png" decoding="async" width="163" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a6/Gray1116.png/244px-Gray1116.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a6/Gray1116.png/326px-Gray1116.png 2x" data-file-width="980" data-file-height="722" /></a></span></div> <div class="gallerytext">Tail end of human embryo thirty-two to thirty-three days old</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:Gray1117.png" class="mw-file-description" title="Tail end of human embryo; from eight and a half to nine weeks old"><img alt="Tail end of human embryo; from eight and a half to nine weeks old" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f6/Gray1117.png/139px-Gray1117.png" decoding="async" width="139" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f6/Gray1117.png/208px-Gray1117.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f6/Gray1117.png/277px-Gray1117.png 2x" data-file-width="462" data-file-height="400" /></a></span></div> <div class="gallerytext">Tail end of human embryo; from eight and a half to nine weeks old</div> </li> </ul> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mesonephric_duct&amp;action=edit&amp;section=9" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Fetal_genital_development" class="mw-redirect" title="Fetal genital development">Fetal genital development</a></li> <li><a href="/wiki/List_of_homologues_of_the_human_reproductive_system" class="mw-redirect" title="List of homologues of the human reproductive system">List of homologues of the human reproductive system</a></li> <li><a href="/wiki/Masculinization" class="mw-redirect" title="Masculinization">Masculinization</a></li> <li><a href="/wiki/M%C3%BCllerian_duct" class="mw-redirect" title="Müllerian duct">Müllerian duct</a></li> <li><a href="/wiki/Sexual_differentiation" title="Sexual differentiation">Sexual differentiation</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mesonephric_duct&amp;action=edit&amp;section=10" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-auto-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-auto_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-auto_1-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><i><a rel="nofollow" class="external text" href="http://www.whonamedit.com/synd.cfm/2845.html">synd/2845</a></i> at <a href="/wiki/Who_Named_It%3F" class="mw-redirect" title="Who Named It?">Who Named It?</a></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFDuTaylor2015" class="citation book cs1">Du, Hongling; Taylor, Hugh S. (January 1, 2015). <a rel="nofollow" class="external text" href="https://www.sciencedirect.com/science/article/pii/B9780124059450000272">"Chapter 27 - Development of the Genital System"</a>. In Moody, Sally A. (ed.). <i>Principles of Developmental Genetics</i> (Second&#160;ed.). Academic Press. pp.&#160;487–504. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fb978-0-12-405945-0.00027-2">10.1016/b978-0-12-405945-0.00027-2</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/9780124059450" title="Special:BookSources/9780124059450"><bdi>9780124059450</bdi></a> &#8211; via ScienceDirect.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=bookitem&amp;rft.atitle=Chapter+27+-+Development+of+the+Genital+System&amp;rft.btitle=Principles+of+Developmental+Genetics&amp;rft.pages=487-504&amp;rft.edition=Second&amp;rft.pub=Academic+Press&amp;rft.date=2015-01-01&amp;rft_id=info%3Adoi%2F10.1016%2Fb978-0-12-405945-0.00027-2&amp;rft.isbn=9780124059450&amp;rft.aulast=Du&amp;rft.aufirst=Hongling&amp;rft.au=Taylor%2C+Hugh+S.&amp;rft_id=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FB9780124059450000272&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AMesonephric+duct" class="Z3988"></span></span> </li> <li id="cite_note-pmid16567946-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid16567946_3-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHannemaPrintCharnock-JonesColeman2006" class="citation journal cs1">Hannema SE, Print CG, Charnock-Jones DS, Coleman N, Hughes IA (2006). "Changes in gene expression during Wolffian duct development". <i>Horm. Res</i>. <b>65</b> (4): 200–9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000092408">10.1159/000092408</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16567946">16567946</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a>&#160;<a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:2444520">2444520</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Horm.+Res.&amp;rft.atitle=Changes+in+gene+expression+during+Wolffian+duct+development&amp;rft.volume=65&amp;rft.issue=4&amp;rft.pages=200-9&amp;rft.date=2006&amp;rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A2444520%23id-name%3DS2CID&amp;rft_id=info%3Apmid%2F16567946&amp;rft_id=info%3Adoi%2F10.1159%2F000092408&amp;rft.aulast=Hannema&amp;rft.aufirst=SE&amp;rft.au=Print%2C+CG&amp;rft.au=Charnock-Jones%2C+DS&amp;rft.au=Coleman%2C+N&amp;rft.au=Hughes%2C+IA&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AMesonephric+duct" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mesonephric_duct&amp;action=edit&amp;section=11" title="Edit section: External links"><span>edit</span></a><span 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href="/wiki/Sexual_differentiation" title="Sexual differentiation">Sexual differentiation</a> <ul><li><a href="/wiki/Sexual_differentiation_in_humans" title="Sexual differentiation in humans">humans</a></li></ul></li> <li><a href="/wiki/Development_of_the_reproductive_system" title="Development of the reproductive system">Development of the reproductive system</a> <ul><li><a href="/wiki/Development_of_the_gonads" title="Development of the gonads">gonads</a></li></ul></li> <li><a class="mw-selflink selflink">Mesonephric duct</a></li> <li><a href="/wiki/Paramesonephric_duct" title="Paramesonephric duct">Paramesonephric duct</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Genetic basis</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sex-determination_system" title="Sex-determination system">Sex-determination system</a> <ul><li><a href="/wiki/XY_sex-determination_system" title="XY sex-determination system">XY</a></li> <li><a href="/wiki/X0_sex-determination_system" class="mw-redirect" title="X0 sex-determination system">X0</a></li> <li><a href="/wiki/ZW_sex-determination_system" title="ZW sex-determination system">ZW</a></li> <li><a href="/wiki/Temperature-dependent_sex_determination" title="Temperature-dependent sex determination">Temperature-dependent</a></li> <li><a href="/wiki/Haplodiploidy" title="Haplodiploidy">Haplodiploidy</a></li></ul></li> <li><a href="/wiki/Sex_chromosome" title="Sex chromosome">Sex chromosome</a> <ul><li><a href="/wiki/X_chromosome" title="X chromosome">X chromosome</a></li> <li><a href="/wiki/Y_chromosome" title="Y chromosome">Y chromosome</a></li></ul></li> <li>Sex determining gene: <a href="/wiki/Testis-determining_factor" class="mw-redirect" title="Testis-determining factor">SRY</a> (mammal) <a href="/wiki/DMRT1" title="DMRT1">DMRT1</a> (birds)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">See also</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Hermaphrodite" title="Hermaphrodite">Hermaphrodite</a></li> <li><a href="/wiki/Intersex" title="Intersex">Intersex</a></li> <li><a href="/wiki/Disorders_of_sex_development" title="Disorders of sex development">Disorders of sex development</a></li> <li><a href="/wiki/Sex_reversal" title="Sex reversal">Sex reversal</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li><span class="noviewer" typeof="mw:File"><span title="Category"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/16px-Symbol_category_class.svg.png" decoding="async" width="16" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/23px-Symbol_category_class.svg.png 1.5x, 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href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Development_of_the_reproductive_system" title="Template:Development of the reproductive system"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Development_of_the_reproductive_system" title="Template talk:Development of the reproductive system"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Development_of_the_reproductive_system" title="Special:EditPage/Template:Development of the reproductive system"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Development_of_the_reproductive_system" style="font-size:114%;margin:0 4em"><a href="/wiki/Development_of_the_reproductive_system" title="Development of the reproductive system">Development of the reproductive system</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Precursors</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mesoderm" title="Mesoderm">Mesoderm</a> <ul><li><a href="/wiki/Intermediate_mesoderm" title="Intermediate mesoderm">intermediate</a></li> <li><a href="/wiki/Lateral_plate_mesoderm" title="Lateral plate mesoderm">lateral plate</a></li></ul></li> <li><a href="/wiki/Endoderm" title="Endoderm">Endoderm</a> <ul><li><a href="/wiki/Cloaca_(embryology)" title="Cloaca (embryology)">Cloaca</a></li> <li><a href="/wiki/Urogenital_sinus" title="Urogenital sinus">Urogenital sinus</a></li></ul></li> <li><a href="/wiki/Ectoderm" title="Ectoderm">Ectoderm</a> <ul><li><a href="/wiki/Cloacal_membrane" title="Cloacal membrane">Cloacal membrane</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Internal</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Development_of_the_gonads" title="Development of the gonads">Development of the gonads</a> <ul><li><a href="/wiki/Gonadal_ridge" class="mw-redirect" title="Gonadal ridge">Gonadal ridge</a></li></ul></li> <li><a href="/wiki/Pronephric_duct" title="Pronephric duct">Pronephric duct</a> <ul><li><a class="mw-selflink selflink">Mesonephric duct</a></li> <li><a href="/wiki/Paramesonephric_duct" title="Paramesonephric duct">Paramesonephric duct</a></li> <li><a href="/wiki/Vaginal_plate" class="mw-redirect" title="Vaginal plate">Vaginal plate</a></li></ul></li> <li><a href="/wiki/Urogenital_sinus" title="Urogenital sinus">Definitive urogenital sinus</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">External</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Genital_tubercle" title="Genital tubercle">Genital tubercle</a> <ul><li><a href="/wiki/Primordial_phallus" title="Primordial phallus">Primordial phallus</a></li></ul></li> <li><a href="/wiki/Labioscrotal_swelling" title="Labioscrotal swelling">Labioscrotal swelling</a></li> <li><a href="/wiki/Development_of_the_reproductive_system#External_genitalia" title="Development of the reproductive system">Urogenital fold</a></li> <li><a href="/wiki/Gubernaculum" title="Gubernaculum">Gubernaculum</a></li> <li><a href="/wiki/Peritoneum" title="Peritoneum">Peritoneum</a> <ul><li><a href="/wiki/Vaginal_process" title="Vaginal process">Vaginal process</a></li> <li><a href="/wiki/Canal_of_Nuck" title="Canal of Nuck">Canal of Nuck</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">See also</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/List_of_related_male_and_female_reproductive_organs" title="List of related male and female reproductive organs">List of related male and female reproductive organs</a></li> <li><a href="/wiki/Prenatal_development" title="Prenatal development">Prenatal development</a></li> <li><a href="/wiki/Embryogenesis" class="mw-redirect" title="Embryogenesis">Embryogenesis</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox authority-control" aria-label="Navbox" style="padding:3px"><table class="nowraplinks hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Help:Authority_control" title="Help:Authority control">Authority control databases</a>: 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