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id="Papers"><h3 class="profile--tab_heading_container">Papers by Alton Farris</h3></div><div class="js-work-strip profile--work_container" data-work-id="124810408"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124810408/Artificial_intelligence_based_liver_portal_tract_region_identification_and_quantification_with_transplant_biopsy_whole_slide_images"><img alt="Research paper thumbnail of Artificial intelligence based liver portal tract region identification and quantification with transplant biopsy whole-slide images" class="work-thumbnail" src="https://attachments.academia-assets.com/118967111/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124810408/Artificial_intelligence_based_liver_portal_tract_region_identification_and_quantification_with_transplant_biopsy_whole_slide_images">Artificial intelligence based liver portal tract region identification and quantification with transplant biopsy whole-slide images</a></div><div class="wp-workCard_item"><span>Computers in Biology and Medicine</span><span>, Nov 1, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb7339b26ae60bc144a2163f05654ba5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118967111,"asset_id":124810408,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118967111/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action 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if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eb7339b26ae60bc144a2163f05654ba5" } } $('.js-work-strip[data-work-id=124810408]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124810408,"title":"Artificial intelligence based liver portal tract region identification and quantification with transplant biopsy whole-slide images","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Liver fibrosis staging is clinically important for liver disease progression prediction. As the portal tract fibrotic quantity and size in a liver biopsy correlate with the fibrosis stage, an accurate analysis of portal tract regions is clinically critical. Manual annotations of portal tract regions, however, are time-consuming and subject to large inter-and intra-observer variability. To address such a challenge, we develop a Multiple Up-sampling and Spatial Attention guided UNet model (MUSA-UNet) to segment liver portal tract regions in whole-slide images of liver tissue slides. To enhance the segmentation performance, we propose to use depth-wise separable convolution, the spatial attention mechanism, the residual connection, and multiple up-sampling paths in the developed model. This study includes 53 histopathology whole slide images from patients who received liver transplantation. In total, 6,012 patches derived from 30 images are used for our deep learning model training and validation. The remaining 23 whole slide images are utilized for the model testing. The average liver portal tract segmentation performance of the developed MUSA-UNet is 0.94 (Precision), 0.85 (Recall), 0.89 (F1 Score), 0.89 (Accuracy), 0.80 (Jaccard Index), and 0.91 (Fowlkes-Mallows Index), respectively. The clinical Scheuer fibrosis stage presents a strong correlation with the resulting average portal tract fibrotic area (R=0.681, p\u003c0.001) and portal tract percentage (R=0.335, p=0.02) computed from the MUSA-UNet segmentation results. In conclusion, our developed deep learning model MUSA-UNet can accurately segment portal tract regions from whole-slide images of liver tissue biopsies, presenting its promising potential to assist liver disease diagnosis in a computational manner.","publication_date":{"day":1,"month":11,"year":2022,"errors":{}},"publication_name":"Computers in Biology and 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and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":45199407,"url":"https://www.biorxiv.org/content/biorxiv/early/2022/09/03/2022.08.31.506101.full.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124810407"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124810407/Quantitative_assessment_of_liver_fibrosis_by_digital_image_analysis_reveals_correlation_with_qualitative_clinical_fibrosis_staging_in_liver_transplant_patients"><img alt="Research paper thumbnail of Quantitative assessment of liver fibrosis by digital image analysis reveals correlation with qualitative clinical fibrosis staging in liver transplant patients" class="work-thumbnail" src="https://attachments.academia-assets.com/118967125/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124810407/Quantitative_assessment_of_liver_fibrosis_by_digital_image_analysis_reveals_correlation_with_qualitative_clinical_fibrosis_staging_in_liver_transplant_patients">Quantitative assessment of liver fibrosis by digital image analysis reveals correlation with qualitative clinical fibrosis staging in liver transplant patients</a></div><div class="wp-workCard_item"><span>PLOS ONE</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e9528b7d6a535868718831ea0a9c86c6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118967125,"asset_id":124810407,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118967125/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124810407"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124810407"><i class="fa fa-spinner 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124810407, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e9528b7d6a535868718831ea0a9c86c6" } } $('.js-work-strip[data-work-id=124810407]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124810407,"title":"Quantitative assessment of liver fibrosis by digital image analysis reveals correlation with qualitative clinical fibrosis staging in liver transplant patients","translated_title":"","metadata":{"publisher":"Public Library of Science (PLoS)","grobid_abstract":"Technologies for digitizing tissues provide important quantitative data for liver histopathology investigation. We aimed to assess liver fibrosis degree with quantitative morphometric measurements of histopathological sections utilizing digital image analysis (DIA) and to further investigate if a correlation with histopathologic scoring (Scheuer staging) exists. A retrospective study of patients with at least two post-liver transplant biopsies having a Scheuer stage of � 2 at baseline were gathered. Portal tract fibrotic percentage (%) and size (μm 2) were measured by DIA, while clinical fibrosis score was measured by the Scheuer system. Correlations between DIA measurements and Scheuer scores were computed by Spearman correlation analysis. Differences between mean levels of fibrosis (score, size, and percentage) at baseline versus second visit were computed by Student's t-test. P values \u003c 0.05 were considered significant. Of 22 patients who met the study criteria, 54 biopsies were included for analysis. Average levels ±standard error [S.E.] of portal tract fibrotic percentage (%) and size (μm 2) progressed from 46.5 ± 3.6% at baseline to 61.8 ± 3.8% at the second visit (P = 0.005 by Student's t-test), and from 28,075 ± 3,232 μm 2 at base line to 67,146 ± 10,639 μm 2 at the second visit (P = 0.002 by Student's t-test), respectively. Average levels of Scheuer fibrosis scores progressed from 0.55±0.19 at baseline to 1.14±0.26 at the second visit (P = 0.02 by Student's t-test). Portal tract fibrotic percentage (%) and portal tract fibrotic size were directly correlated with clinical Scheuer fibrosis stage, with Spearman correlation coefficient and P value computed as r = 0.70, P \u003c 0.0001 and r = 0.41, P = 0.002, respectively. Digital quantitative assessment of portal triad size and fibrosis percentage demonstrates a strong correlation with visually assessed histologic stage of liver fibrosis","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"PLOS ONE","grobid_abstract_attachment_id":118967125},"translated_abstract":null,"internal_url":"https://www.academia.edu/124810407/Quantitative_assessment_of_liver_fibrosis_by_digital_image_analysis_reveals_correlation_with_qualitative_clinical_fibrosis_staging_in_liver_transplant_patients","translated_internal_url":"","created_at":"2024-10-17T08:01:38.501-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":118967125,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/118967125/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/118967125/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Quantitative_assessment_of_liver_fibrosi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/118967125/pdf-libre.pdf?1729179322=\u0026response-content-disposition=attachment%3B+filename%3DQuantitative_assessment_of_liver_fibrosi.pdf\u0026Expires=1733187490\u0026Signature=cqMp2SE7hP0HLnkFoDofTHN4mUA332LASIwM9qi4sOL5NU9Ef~cJmjt12o0Y-inmDpyHXNoMdOCN-fgZNAdH2JnNLf4bVm3WT5gRdnKO~0PblWnDohhCf9j~9PFqXr06DuZ33qsXivVgeo~-X-aBSMpFVzMlA91ZtKQ540cldq5dv5rgJEYGRUWeeBV9e3lWKOg-6eikBbnSqdKVselnXnjUZP3Jei9wBTItLmxatp750BCxSCAnm7ub8eQPHyyTFNuS~-LuB2wcLrXzcqgUQYWIctfj5j9AESvfD5KDnDR~igTBb7p6XkRqBZypaoaUJaAYb9fkqu8ajJBsi-Ya6Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Quantitative_assessment_of_liver_fibrosis_by_digital_image_analysis_reveals_correlation_with_qualitative_clinical_fibrosis_staging_in_liver_transplant_patients","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":118967125,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/118967125/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/118967125/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Quantitative_assessment_of_liver_fibrosi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/118967125/pdf-libre.pdf?1729179322=\u0026response-content-disposition=attachment%3B+filename%3DQuantitative_assessment_of_liver_fibrosi.pdf\u0026Expires=1733187490\u0026Signature=cqMp2SE7hP0HLnkFoDofTHN4mUA332LASIwM9qi4sOL5NU9Ef~cJmjt12o0Y-inmDpyHXNoMdOCN-fgZNAdH2JnNLf4bVm3WT5gRdnKO~0PblWnDohhCf9j~9PFqXr06DuZ33qsXivVgeo~-X-aBSMpFVzMlA91ZtKQ540cldq5dv5rgJEYGRUWeeBV9e3lWKOg-6eikBbnSqdKVselnXnjUZP3Jei9wBTItLmxatp750BCxSCAnm7ub8eQPHyyTFNuS~-LuB2wcLrXzcqgUQYWIctfj5j9AESvfD5KDnDR~igTBb7p6XkRqBZypaoaUJaAYb9fkqu8ajJBsi-Ya6Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3274,"name":"Gastroenterology","url":"https://www.academia.edu/Documents/in/Gastroenterology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":76863,"name":"Histopathology","url":"https://www.academia.edu/Documents/in/Histopathology"},{"id":125176,"name":"Liver Fibrosis","url":"https://www.academia.edu/Documents/in/Liver_Fibrosis"},{"id":126289,"name":"Digital Image Analysis","url":"https://www.academia.edu/Documents/in/Digital_Image_Analysis"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"}],"urls":[{"id":45199406,"url":"https://dx.plos.org/10.1371/journal.pone.0239624"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124810405"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124810405/Evidence_for_Kidney_Rejection_After_Combined_Bone_Marrow_and_Renal_Transplantation_Despite_Ongoing_Whole_Blood_Chimerism_in_Rhesus_Macaques"><img alt="Research paper thumbnail of Evidence for Kidney Rejection After Combined Bone Marrow and Renal Transplantation Despite Ongoing Whole-Blood Chimerism in Rhesus Macaques" class="work-thumbnail" src="https://attachments.academia-assets.com/118967109/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124810405/Evidence_for_Kidney_Rejection_After_Combined_Bone_Marrow_and_Renal_Transplantation_Despite_Ongoing_Whole_Blood_Chimerism_in_Rhesus_Macaques">Evidence for Kidney Rejection After Combined Bone Marrow and Renal Transplantation Despite Ongoing Whole-Blood Chimerism in Rhesus Macaques</a></div><div class="wp-workCard_item"><span>American Journal of Transplantation</span><span>, Jul 1, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="323838c5a329dd01f66254f867c15465" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118967109,"asset_id":124810405,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118967109/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124810405"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124810405"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124810405; 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To address this, we used an MHC-defined primate model to determine the impact of impermanent, T cell-poor, mixed-chimerism on renal allograft survival. We compared two cohorts: one receiving a bone marrow + renal transplant (\"BMT/renal\") and one receiving only a renal transplant. Both cohorts received maintenance immunosuppression with CD28/CD40directed costimulation blockade and sirolimus. As previously demonstrated, this transplant strategy consistently induced compartmentalized donor chimerism, (significant whole-blood chimerism, lacking T cell chimerism). This chimerism was not sufficient to prolong renal allograft acceptance: the BMT/renal mean survival time (MST, 76 days) was not significantly different than the renal transplant alone MST (85 days, p= 0. 46), with histopathology documenting T-cell mediated rejection. Flow cytometric analysis revealed significant enrichment for CD28-/CD95+ CD4+ and CD8+ Tem cells in the rejected kidney, suggesting a link between CD28-negative Tem and costimulation blockade-resistant rejection. These results suggest that in some settings, transient T cell-poor chimerism is not sufficient to induce tolerance to a concurrently placed renal allograft and that the presence of this chimerism per se is not an independent biomarker to identify tolerance.","publication_date":{"day":1,"month":7,"year":2012,"errors":{}},"publication_name":"American Journal of 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transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression"},{"id":214902,"name":"Chimerism","url":"https://www.academia.edu/Documents/in/Chimerism"},{"id":338534,"name":"Biomarker","url":"https://www.academia.edu/Documents/in/Biomarker"},{"id":354937,"name":"Bone Marrow Transplantation","url":"https://www.academia.edu/Documents/in/Bone_Marrow_Transplantation"},{"id":573267,"name":"Macaca Mulatta","url":"https://www.academia.edu/Documents/in/Macaca_Mulatta"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":45199405,"url":"https://europepmc.org/articles/pmc3387328?pdf=render"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114997747"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114997747/Beyond_a_Broken_Heart_Circulatory_Dysfunction_in_the_Failing_Fontan"><img alt="Research paper thumbnail of Beyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114997747/Beyond_a_Broken_Heart_Circulatory_Dysfunction_in_the_Failing_Fontan">Beyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan</a></div><div class="wp-workCard_item"><span>Pediatric Cardiology</span><span>, Feb 15, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has been described previously. However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ventricular function. The clinical deterioration in patients who have undergone Fontan palliation requires a broader view of circulatory dysfunction, one that takes into account the complex interaction of regulatory systems affecting hepatic, renal, and pulmonary blood flow, in addition to cardiac function. This review focuses primarily on the pathophysiology of multiple organ involvement in this circulatory dysfunction, with particular focus on the consequences of hepatic dysfunction and portal hypertension. The authors discuss hepatic perfusion, both in health and disease, and review the current understanding of liver histopathology and liver disease in adult Fontan patients and similar clinicopathologic states. They compare and contrast features of postsinusoidal portal hypertension with more typical adult cirrhotic disease. Finally, they delineate the related effects of portal hypertensive physiology on the systemic and pulmonary vasculature, the kidney, and the heart itself and discuss how these changes affect the care of the adult Fontan patient.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114997747"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114997747"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114997747; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114997747]").text(description); $(".js-view-count[data-work-id=114997747]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114997747; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114997747']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114997747, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114997747]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114997747,"title":"Beyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan","translated_title":"","metadata":{"abstract":"The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has been described previously. However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ventricular function. The clinical deterioration in patients who have undergone Fontan palliation requires a broader view of circulatory dysfunction, one that takes into account the complex interaction of regulatory systems affecting hepatic, renal, and pulmonary blood flow, in addition to cardiac function. This review focuses primarily on the pathophysiology of multiple organ involvement in this circulatory dysfunction, with particular focus on the consequences of hepatic dysfunction and portal hypertension. The authors discuss hepatic perfusion, both in health and disease, and review the current understanding of liver histopathology and liver disease in adult Fontan patients and similar clinicopathologic states. They compare and contrast features of postsinusoidal portal hypertension with more typical adult cirrhotic disease. Finally, they delineate the related effects of portal hypertensive physiology on the systemic and pulmonary vasculature, the kidney, and the heart itself and discuss how these changes affect the care of the adult Fontan patient.","publisher":"Springer Science+Business Media","publication_date":{"day":15,"month":2,"year":2014,"errors":{}},"publication_name":"Pediatric Cardiology"},"translated_abstract":"The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has been described previously. However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ventricular function. The clinical deterioration in patients who have undergone Fontan palliation requires a broader view of circulatory dysfunction, one that takes into account the complex interaction of regulatory systems affecting hepatic, renal, and pulmonary blood flow, in addition to cardiac function. This review focuses primarily on the pathophysiology of multiple organ involvement in this circulatory dysfunction, with particular focus on the consequences of hepatic dysfunction and portal hypertension. The authors discuss hepatic perfusion, both in health and disease, and review the current understanding of liver histopathology and liver disease in adult Fontan patients and similar clinicopathologic states. They compare and contrast features of postsinusoidal portal hypertension with more typical adult cirrhotic disease. Finally, they delineate the related effects of portal hypertensive physiology on the systemic and pulmonary vasculature, the kidney, and the heart itself and discuss how these changes affect the care of the adult Fontan patient.","internal_url":"https://www.academia.edu/114997747/Beyond_a_Broken_Heart_Circulatory_Dysfunction_in_the_Failing_Fontan","translated_internal_url":"","created_at":"2024-02-16T11:28:22.102-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Beyond_a_Broken_Heart_Circulatory_Dysfunction_in_the_Failing_Fontan","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology"},{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension"},{"id":37788,"name":"Pediatric Cardiology","url":"https://www.academia.edu/Documents/in/Pediatric_Cardiology"},{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71342,"name":"Portal hypertension","url":"https://www.academia.edu/Documents/in/Portal_hypertension"},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate"},{"id":1154249,"name":"Heart Ventricles","url":"https://www.academia.edu/Documents/in/Heart_Ventricles"},{"id":3306139,"name":"Treatment Failure","url":"https://www.academia.edu/Documents/in/Treatment_Failure"},{"id":3378593,"name":"Fontan procedure","url":"https://www.academia.edu/Documents/in/Fontan_procedure"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":39523524,"url":"https://doi.org/10.1007/s00246-014-0881-y"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114997746"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114997746/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation"><img alt="Research paper thumbnail of Clinical Utility of Liver Biopsy in Adults with Fontan Palliation" class="work-thumbnail" src="https://attachments.academia-assets.com/111535315/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114997746/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation">Clinical Utility of Liver Biopsy in Adults with Fontan Palliation</a></div><div class="wp-workCard_item"><span>Journal of the American College of Cardiology</span><span>, Mar 1, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1e8fae0d952f332d3529fcea8ee96ebf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111535315,"asset_id":114997746,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111535315/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114997746"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114997746"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114997746; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114997746]").text(description); $(".js-view-count[data-work-id=114997746]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114997746; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114997746']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114997746, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1e8fae0d952f332d3529fcea8ee96ebf" } } $('.js-work-strip[data-work-id=114997746]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114997746,"title":"Clinical Utility of Liver Biopsy in Adults with Fontan Palliation","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Background: Liver fibrosis is a common complication after Fontan palliation for single ventricle heart defects, but the clinical utility of liver biopsies is unclear. The purpose of this study was to determine if degree of liver fibrosis on biopsy correlates with clinical findings. methods: A chart review of adults with Fontan palliation and a liver biopsy at Emory's Adult Congenital Heart Center was performed (2001-2011). Core liver biopsies were examined using digitally scanned whole slide images of trichrome-stained sections. Portal and lobular fibrosis were quantitated using a positive pixel count algorithm tuned to detect fibrosis. Logistic regression and bivariate correlations were used to examine the relationship between fibrosis and ventricular dysfunction, IVC diameter, clinical features of portal hypertension (defined as ≥2 of the following: platelets \u003c150K, splenomegaly, varices, ascites), and adverse outcomes (death, transplant, or hepatocellular carcinoma [HCC]). results: Ten adults were identified (40% female, mean age 31±7 years). Mean time since Fontan was 18.6 years (range: 6-29), 7 had atriopulmonary connection of whom 4 underwent revision, 8 had a systemic left ventricle, 1 had ventricular dysfunction, and mean IVC diameter was 2.1 ± .23 cm. On biopsy, mean portal area was 1.4 x 105 ± 8.7 x 104 um2 and portal % fibrosis was 66% ± 16%. Mean lobular area was 5.9 x 105 ± 2.4 x 105 um2 and lobular % fibrosis was 20% ± 19%. Features of portal hypertension were present in 7, and 3 had an adverse outcome (death=1, transplant=1, HCC=1). No relationship was found between fibrosis and ventricular dysfunction (p=.26-.59), features of portal hypertension (p=.39-.98), or clinical outcomes (p=.14-.98). A strong positive correlation was found between mean portal area and time since Fontan (r= .82, p=.003) and a moderate trending correlation between portal % fibrosis and IVC diameter (r= .59, p=.07). conclusion: In adult patients following Fontan palliation, quantitative portal fibrosis by liver biopsy increases with time since surgery but does not correlate with clinical outcomes. Further evaluation in a larger population is needed to confirm these findings.","publication_date":{"day":1,"month":3,"year":2013,"errors":{}},"publication_name":"Journal of the American College of Cardiology","grobid_abstract_attachment_id":111535315},"translated_abstract":null,"internal_url":"https://www.academia.edu/114997746/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation","translated_internal_url":"","created_at":"2024-02-16T11:28:21.548-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":111535315,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111535315/thumbnails/1.jpg","file_name":"S0735-109728132960430-120240216-1-jsq9zu.pdf","download_url":"https://www.academia.edu/attachments/111535315/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Utility_of_Liver_Biopsy_in_Adul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111535315/S0735-109728132960430-120240216-1-jsq9zu-libre.pdf?1708113406=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Utility_of_Liver_Biopsy_in_Adul.pdf\u0026Expires=1733187490\u0026Signature=AIyv-dkLLt5UU35-Esg7PMVZxUeiW~4cCT9WYeuNqQ9qGudluwGnUE951yXWqLmkze7FWZm9Dl0AaitvQRI~9cCM8BTx0AKxyihYw5dY~nutR9zY~EBMLmr27Jk6kz1qiPhOpWio5R2NAdiLOoaqALNK3MrUgF6IEKIHzBAcL66UvEsJQHVrBp0yMad67zbi5jqB2bPRxVuUbNMFegaeCLdmwFNN-kLJF7LbpieQM82kRad2qq~vIrKUVYVoCpXUDpScmBkECKwc3LJ5FAQOQaNgtjP2iyiXn76wQmMYTRgg-Nt1fpyjd2nfibvL3aPKhquOvVQ2pn8v4aCfB7k~Ew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":111535315,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111535315/thumbnails/1.jpg","file_name":"S0735-109728132960430-120240216-1-jsq9zu.pdf","download_url":"https://www.academia.edu/attachments/111535315/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Utility_of_Liver_Biopsy_in_Adul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111535315/S0735-109728132960430-120240216-1-jsq9zu-libre.pdf?1708113406=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Utility_of_Liver_Biopsy_in_Adul.pdf\u0026Expires=1733187490\u0026Signature=AIyv-dkLLt5UU35-Esg7PMVZxUeiW~4cCT9WYeuNqQ9qGudluwGnUE951yXWqLmkze7FWZm9Dl0AaitvQRI~9cCM8BTx0AKxyihYw5dY~nutR9zY~EBMLmr27Jk6kz1qiPhOpWio5R2NAdiLOoaqALNK3MrUgF6IEKIHzBAcL66UvEsJQHVrBp0yMad67zbi5jqB2bPRxVuUbNMFegaeCLdmwFNN-kLJF7LbpieQM82kRad2qq~vIrKUVYVoCpXUDpScmBkECKwc3LJ5FAQOQaNgtjP2iyiXn76wQmMYTRgg-Nt1fpyjd2nfibvL3aPKhquOvVQ2pn8v4aCfB7k~Ew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":3752221,"name":"Liver biopsy","url":"https://www.academia.edu/Documents/in/Liver_biopsy"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":39523523,"url":"https://doi.org/10.1016/s0735-1097(13)60430-1"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114997744"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114997744/PRO_C3_a_Serological_Marker_of_Fibrosis_During_Childhood_and_Correlations_With_Fibrosis_in_Pediatric_NAFLD"><img alt="Research paper thumbnail of PRO‐C3, a Serological Marker of Fibrosis, During Childhood and Correlations With Fibrosis in Pediatric NAFLD" class="work-thumbnail" src="https://attachments.academia-assets.com/111535314/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114997744/PRO_C3_a_Serological_Marker_of_Fibrosis_During_Childhood_and_Correlations_With_Fibrosis_in_Pediatric_NAFLD">PRO‐C3, a Serological Marker of Fibrosis, During Childhood and Correlations With Fibrosis in Pediatric NAFLD</a></div><div class="wp-workCard_item"><span>Hepatology Communications</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease in children and may le...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease in children and may lead to cirrhosis requiring liver transplant. Thus, prompt diagnosis of advanced fibrosis is essential. Our objectives were to examine PRO‐C3 (a neo‐epitope pro‐peptide of type III collagen formation) levels across childhood/adolescence and associations with advanced fibrosis in pediatric NAFLD. This cross‐sectional study included 88 children and adolescents with biopsy‐proven NAFLD (mean age: 13.9 ± 2.9 years, 71% male) and 65 healthy participants (11.8 ± 4.5 years, 38% male). PRO‐C3, and the bone remodeling biomarkers C‐terminal telopeptide of type I collagen (CTX‐I; bone resorption) and osteocalcin (N‐MID; bone formation), were measured in serum by enzyme‐linked immunosorbent assay. Fibrosis was assessed by liver biopsy in participants with NAFLD, who were categorized as having advanced (Ishak score ≥ 3) or none/mild fibrosis (Ishak score ≤ 2). Overall, PRO‐C3 was similar in participant...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b09789a1f43b5d4cc130d5e1a8b96be2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111535314,"asset_id":114997744,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111535314/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114997744"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114997744"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114997744; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114997744]").text(description); $(".js-view-count[data-work-id=114997744]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114997744; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114997744']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114997744, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b09789a1f43b5d4cc130d5e1a8b96be2" } } $('.js-work-strip[data-work-id=114997744]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114997744,"title":"PRO‐C3, a Serological Marker of Fibrosis, During Childhood and Correlations With Fibrosis in Pediatric NAFLD","translated_title":"","metadata":{"abstract":"Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease in children and may lead to cirrhosis requiring liver transplant. Thus, prompt diagnosis of advanced fibrosis is essential. Our objectives were to examine PRO‐C3 (a neo‐epitope pro‐peptide of type III collagen formation) levels across childhood/adolescence and associations with advanced fibrosis in pediatric NAFLD. This cross‐sectional study included 88 children and adolescents with biopsy‐proven NAFLD (mean age: 13.9 ± 2.9 years, 71% male) and 65 healthy participants (11.8 ± 4.5 years, 38% male). PRO‐C3, and the bone remodeling biomarkers C‐terminal telopeptide of type I collagen (CTX‐I; bone resorption) and osteocalcin (N‐MID; bone formation), were measured in serum by enzyme‐linked immunosorbent assay. Fibrosis was assessed by liver biopsy in participants with NAFLD, who were categorized as having advanced (Ishak score ≥ 3) or none/mild fibrosis (Ishak score ≤ 2). Overall, PRO‐C3 was similar in participant...","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_name":"Hepatology Communications"},"translated_abstract":"Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease in children and may lead to cirrhosis requiring liver transplant. Thus, prompt diagnosis of advanced fibrosis is essential. Our objectives were to examine PRO‐C3 (a neo‐epitope pro‐peptide of type III collagen formation) levels across childhood/adolescence and associations with advanced fibrosis in pediatric NAFLD. This cross‐sectional study included 88 children and adolescents with biopsy‐proven NAFLD (mean age: 13.9 ± 2.9 years, 71% male) and 65 healthy participants (11.8 ± 4.5 years, 38% male). PRO‐C3, and the bone remodeling biomarkers C‐terminal telopeptide of type I collagen (CTX‐I; bone resorption) and osteocalcin (N‐MID; bone formation), were measured in serum by enzyme‐linked immunosorbent assay. Fibrosis was assessed by liver biopsy in participants with NAFLD, who were categorized as having advanced (Ishak score ≥ 3) or none/mild fibrosis (Ishak score ≤ 2). Overall, PRO‐C3 was similar in participant...","internal_url":"https://www.academia.edu/114997744/PRO_C3_a_Serological_Marker_of_Fibrosis_During_Childhood_and_Correlations_With_Fibrosis_in_Pediatric_NAFLD","translated_internal_url":"","created_at":"2024-02-16T11:28:20.977-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":111535314,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111535314/thumbnails/1.jpg","file_name":"pmc8557318.pdf","download_url":"https://www.academia.edu/attachments/111535314/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"PRO_C3_a_Serological_Marker_of_Fibrosis.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111535314/pmc8557318-libre.pdf?1708113415=\u0026response-content-disposition=attachment%3B+filename%3DPRO_C3_a_Serological_Marker_of_Fibrosis.pdf\u0026Expires=1733187490\u0026Signature=ZffCsf5dd~7g~H83rBZg~LSyQfMNh6Y3ubQqzgR-YHNrqtA9eUE4qkk38TPkAddae0ncdRuCQfZ6CoU40KDBjhlYk9EuWe7RLrZo-tM6KvyFOzym3lESpRkb3KJnS3ht22FFq38NwtLMW3caNjZ1wMgo~b~214HGHa-FcBki46RkFOiV49MqDyKh2r2~~icqxI4Yef46ASmGtGeE47EagcdAQnVVAEYnKXeAlQbTLqbVXu6mQA0moX9NbjO4MqejR4bxJKDr2vXZHlJB68fey2MFn7XuPuDE9pHsumEEbym3G3NnoiNfFQTG~Dt-r~wL5gqV5hky~-zVpyCBqvIz~Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"PRO_C3_a_Serological_Marker_of_Fibrosis_During_Childhood_and_Correlations_With_Fibrosis_in_Pediatric_NAFLD","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":111535314,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111535314/thumbnails/1.jpg","file_name":"pmc8557318.pdf","download_url":"https://www.academia.edu/attachments/111535314/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"PRO_C3_a_Serological_Marker_of_Fibrosis.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111535314/pmc8557318-libre.pdf?1708113415=\u0026response-content-disposition=attachment%3B+filename%3DPRO_C3_a_Serological_Marker_of_Fibrosis.pdf\u0026Expires=1733187490\u0026Signature=ZffCsf5dd~7g~H83rBZg~LSyQfMNh6Y3ubQqzgR-YHNrqtA9eUE4qkk38TPkAddae0ncdRuCQfZ6CoU40KDBjhlYk9EuWe7RLrZo-tM6KvyFOzym3lESpRkb3KJnS3ht22FFq38NwtLMW3caNjZ1wMgo~b~214HGHa-FcBki46RkFOiV49MqDyKh2r2~~icqxI4Yef46ASmGtGeE47EagcdAQnVVAEYnKXeAlQbTLqbVXu6mQA0moX9NbjO4MqejR4bxJKDr2vXZHlJB68fey2MFn7XuPuDE9pHsumEEbym3G3NnoiNfFQTG~Dt-r~wL5gqV5hky~-zVpyCBqvIz~Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3274,"name":"Gastroenterology","url":"https://www.academia.edu/Documents/in/Gastroenterology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":600778,"name":"Cirrhosis","url":"https://www.academia.edu/Documents/in/Cirrhosis"},{"id":3102313,"name":"Nonalcoholic fatty liver disease","url":"https://www.academia.edu/Documents/in/Nonalcoholic_fatty_liver_disease"}],"urls":[{"id":39523521,"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/hep4.1766"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114997743"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114997743/Collagen_Type_III_and_VI_Remodeling_Biomarkers_Are_Associated_with_Kidney_Fibrosis_in_Lupus_Nephritis"><img alt="Research paper thumbnail of Collagen Type III and VI Remodeling Biomarkers Are Associated with Kidney Fibrosis in Lupus Nephritis" class="work-thumbnail" src="https://attachments.academia-assets.com/111535313/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114997743/Collagen_Type_III_and_VI_Remodeling_Biomarkers_Are_Associated_with_Kidney_Fibrosis_in_Lupus_Nephritis">Collagen Type III and VI Remodeling Biomarkers Are Associated with Kidney Fibrosis in Lupus Nephritis</a></div><div class="wp-workCard_item"><span>Kidney360</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Key Points Prognostic biomarkers that identify patients with SLE at risk of developing lupus neph...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Key Points Prognostic biomarkers that identify patients with SLE at risk of developing lupus nephritis and progressing to kidney failure are needed.Tubulointerstitial fibrosis is an important pathologic feature of lupus nephritis and is associated with kidney disease progression.Circulatory and urinary markers of collagen type III and type VI remodeling noninvasively reflect levels of kidney fibrosis in patients with lupus nephritis. Background Lupus nephritis (LN) occurs in &lt;40% of patients with SLE. Reliable biomarkers of kidney damage are needed to identify patients with SLE at risk of developing LN to improve screening, treat the disease earlier, and halt progression to kidney failure. Novel biomarkers of extracellular matrix remodeling were evaluated as markers of kidney fibrosis and disease activity in patients with LN. Methods Biomarkers of the interstitial collagen type III (PRO-C3) and type VI (PRO-C6) formation and of collagen type III (C3M) degradation were evaluated i...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b7754beef778d98ea38ab96628c8214d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111535313,"asset_id":114997743,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111535313/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114997743"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114997743"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114997743; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114997743]").text(description); $(".js-view-count[data-work-id=114997743]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114997743; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114997743']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114997743, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b7754beef778d98ea38ab96628c8214d" } } $('.js-work-strip[data-work-id=114997743]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114997743,"title":"Collagen Type III and VI Remodeling Biomarkers Are Associated with Kidney Fibrosis in Lupus Nephritis","translated_title":"","metadata":{"abstract":"Key Points Prognostic biomarkers that identify patients with SLE at risk of developing lupus nephritis and progressing to kidney failure are needed.Tubulointerstitial fibrosis is an important pathologic feature of lupus nephritis and is associated with kidney disease progression.Circulatory and urinary markers of collagen type III and type VI remodeling noninvasively reflect levels of kidney fibrosis in patients with lupus nephritis. Background Lupus nephritis (LN) occurs in \u0026lt;40% of patients with SLE. Reliable biomarkers of kidney damage are needed to identify patients with SLE at risk of developing LN to improve screening, treat the disease earlier, and halt progression to kidney failure. Novel biomarkers of extracellular matrix remodeling were evaluated as markers of kidney fibrosis and disease activity in patients with LN. Methods Biomarkers of the interstitial collagen type III (PRO-C3) and type VI (PRO-C6) formation and of collagen type III (C3M) degradation were evaluated i...","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Kidney360"},"translated_abstract":"Key Points Prognostic biomarkers that identify patients with SLE at risk of developing lupus nephritis and progressing to kidney failure are needed.Tubulointerstitial fibrosis is an important pathologic feature of lupus nephritis and is associated with kidney disease progression.Circulatory and urinary markers of collagen type III and type VI remodeling noninvasively reflect levels of kidney fibrosis in patients with lupus nephritis. Background Lupus nephritis (LN) occurs in \u0026lt;40% of patients with SLE. Reliable biomarkers of kidney damage are needed to identify patients with SLE at risk of developing LN to improve screening, treat the disease earlier, and halt progression to kidney failure. Novel biomarkers of extracellular matrix remodeling were evaluated as markers of kidney fibrosis and disease activity in patients with LN. Methods Biomarkers of the interstitial collagen type III (PRO-C3) and type VI (PRO-C6) formation and of collagen type III (C3M) degradation were evaluated i...","internal_url":"https://www.academia.edu/114997743/Collagen_Type_III_and_VI_Remodeling_Biomarkers_Are_Associated_with_Kidney_Fibrosis_in_Lupus_Nephritis","translated_internal_url":"","created_at":"2024-02-16T11:28:20.540-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":111535313,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111535313/thumbnails/1.jpg","file_name":"KID.0001132021.full.pdf","download_url":"https://www.academia.edu/attachments/111535313/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Collagen_Type_III_and_VI_Remodeling_Biom.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111535313/KID.0001132021.full-libre.pdf?1708113420=\u0026response-content-disposition=attachment%3B+filename%3DCollagen_Type_III_and_VI_Remodeling_Biom.pdf\u0026Expires=1733187491\u0026Signature=Yye84wHs9SZl7WW-HvanGzC5VJBB8R7BHCWl2tT9jyNSvcY-CpInrX2LnV~JL-ypdEDC2OFt9bnOBaqbtQPppQoMtMjHlmLLU-3cJ8jF1BBlDKJ9sGFEPKrZML0fEbStAYxiCgyQ7~xyK5igM7pv~m2lPN~f6Ji9j7wYUL9lkTse1ro8jk3vTRpuhhgTGM3xZz~7-mI-HkfiHugVx0TwyugDim8aFZITnAArcwgspAVcoos7AlGkQh3uSSw8MzmRJKGy~iD6B~bl8Jlc5DMG3JR~PMQqCExeSduUIBuicjqkZzG90is6dm-xSd3Kd~-lvP5sw1a8Da~v9T23d-8sKQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Collagen_Type_III_and_VI_Remodeling_Biomarkers_Are_Associated_with_Kidney_Fibrosis_in_Lupus_Nephritis","translated_slug":"","page_count":25,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":111535313,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111535313/thumbnails/1.jpg","file_name":"KID.0001132021.full.pdf","download_url":"https://www.academia.edu/attachments/111535313/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Collagen_Type_III_and_VI_Remodeling_Biom.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111535313/KID.0001132021.full-libre.pdf?1708113420=\u0026response-content-disposition=attachment%3B+filename%3DCollagen_Type_III_and_VI_Remodeling_Biom.pdf\u0026Expires=1733187491\u0026Signature=Yye84wHs9SZl7WW-HvanGzC5VJBB8R7BHCWl2tT9jyNSvcY-CpInrX2LnV~JL-ypdEDC2OFt9bnOBaqbtQPppQoMtMjHlmLLU-3cJ8jF1BBlDKJ9sGFEPKrZML0fEbStAYxiCgyQ7~xyK5igM7pv~m2lPN~f6Ji9j7wYUL9lkTse1ro8jk3vTRpuhhgTGM3xZz~7-mI-HkfiHugVx0TwyugDim8aFZITnAArcwgspAVcoos7AlGkQh3uSSw8MzmRJKGy~iD6B~bl8Jlc5DMG3JR~PMQqCExeSduUIBuicjqkZzG90is6dm-xSd3Kd~-lvP5sw1a8Da~v9T23d-8sKQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":165,"name":"Pathology","url":"https://www.academia.edu/Documents/in/Pathology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":440320,"name":"Lupus Nephritis","url":"https://www.academia.edu/Documents/in/Lupus_Nephritis"}],"urls":[{"id":39523520,"url":"https://journals.lww.com/10.34067/KID.0001132021"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114997740"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114997740/Segmentation_of_Overlapped_Steatosis_in_Whole_Slide_Liver_Histopathology_Microscopy_Images"><img alt="Research paper thumbnail of Segmentation of Overlapped Steatosis in Whole-Slide Liver Histopathology Microscopy Images" class="work-thumbnail" src="https://attachments.academia-assets.com/111535304/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114997740/Segmentation_of_Overlapped_Steatosis_in_Whole_Slide_Liver_Histopathology_Microscopy_Images">Segmentation of Overlapped Steatosis in Whole-Slide Liver Histopathology Microscopy Images</a></div><div class="wp-workCard_item"><span>2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)</span><span>, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e623d08cd07d77e2d7851ee6d6d77328" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111535304,"asset_id":114997740,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111535304/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114997740"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114997740"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114997740; 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However, such pathology measurement is manually made in most clinical practices, subject to severe reader variability due to large sampling bias and poor reproducibility. Although some computerized automated methods are developed to quantify the steatosis regions, they present limited analysis capacity for high resolution whole-slide microscopy images and accurate overlapped steatosis division. In this paper, we propose a method that extracts an individual whole tissue piece at high resolution with minimum background area by estimating tissue bounding box and rotation angle. This is followed by the segmentation and segregation of steatosis regions with high curvature point detection and an ellipse fitting quality assessment method. We validate our method with isolated and overlapped steatosis regions in liver tissue images of 11 patients. 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Effect of genetic deletion of MLCK on unmanipulated mice. No statistically significant differences were seen between WT and MLCK-/mice in gut epithelial apoptosis by (A) H\u0026E (p = 0.10) or (B) active caspase 3 (p = 0.18), (C) crypt proliferation (p = 0.19), (D) villus length (p = 0.52), (E) lung MPO (p = 0.20) or (F) BAL MPO (p = 0.22). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81898967"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/81898967/Beyond_a_Broken_Heart_Circulatory_Dysfunction_in_the_Failing_Fontan"><img alt="Research paper thumbnail of Beyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/81898967/Beyond_a_Broken_Heart_Circulatory_Dysfunction_in_the_Failing_Fontan">Beyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan</a></div><div class="wp-workCard_item"><span>Pediatric Cardiology</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has been described previously. However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ventricular function. The clinical deterioration in patients who have undergone Fontan palliation requires a broader view of circulatory dysfunction, one that takes into account the complex interaction of regulatory systems affecting hepatic, renal, and pulmonary blood flow, in addition to cardiac function. This review focuses primarily on the pathophysiology of multiple organ involvement in this circulatory dysfunction, with particular focus on the consequences of hepatic dysfunction and portal hypertension. The authors discuss hepatic perfusion, both in health and disease, and review the current understanding of liver histopathology and liver disease in adult Fontan patients and similar clinicopathologic states. They compare and contrast features of postsinusoidal portal hypertension with more typical adult cirrhotic disease. 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898842/Morphometric_and_Visual_Evaluation_of_Fibrosis_in_Renal_Biopsies"><img alt="Research paper thumbnail of Morphometric and Visual Evaluation of Fibrosis in Renal Biopsies" class="work-thumbnail" src="https://attachments.academia-assets.com/87781646/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898842/Morphometric_and_Visual_Evaluation_of_Fibrosis_in_Renal_Biopsies">Morphometric and Visual Evaluation of Fibrosis in Renal Biopsies</a></div><div class="wp-workCard_item"><span>Journal of the American Society of Nephrology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span 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Collagen III, Sirius Red unpolarized, and visual scores had the strongest correlations (R 2 ϭ 0.78 to 0.89), the greatest dynamic range, and the best correlation with estimated GFR (R 2 ϭ 0.38 to 0.50, P Ͻ 0.01 to 0.001). Considering efficiency, reproducibility, and functional correlation, two current techniques stand out as potentially the best for clinical trials: collagen III morphometry and visual assessment of trichrome-stained slides.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of the American Society of Nephrology","grobid_abstract_attachment_id":87781646},"translated_abstract":null,"internal_url":"https://www.academia.edu/81898842/Morphometric_and_Visual_Evaluation_of_Fibrosis_in_Renal_Biopsies","translated_internal_url":"","created_at":"2022-06-20T05:57:54.402-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":87781646,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781646/thumbnails/1.jpg","file_name":"176.full.pdf","download_url":"https://www.academia.edu/attachments/87781646/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Morphometric_and_Visual_Evaluation_of_Fi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781646/176.full-libre.pdf?1655730471=\u0026response-content-disposition=attachment%3B+filename%3DMorphometric_and_Visual_Evaluation_of_Fi.pdf\u0026Expires=1733187491\u0026Signature=gW-kdy-XeQchQXVOWarxkDANqdHQJXcX66tObIqnaqeYZ25UUCkdoTFJP~fYqs-dBSLonPjEDIbOqByh-SpBdQPZ705w0V-v76t3yugHhyUhLbxFG3x5qXvn4tYf~55cZLwFWqHfsF0KGJpB5oF2qleyglbF~WW5Y7nt-QOtIyIrWHrT~sXPbpQ8AHq0xnEaBF1Jj-~dV2LTV1~dt6X~GYF-XuU-7KbdXUG0ygyB281G4aMDnkB-wpaMT6BpCnrj8ajVuXBfiutJ1tYU0WbZnM3W2BqAtVi92eerNfga8pFMFOf6oTFQuK0EOBnIuxZKUv6oqEekCSuCBhr9p3rLuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Morphometric_and_Visual_Evaluation_of_Fibrosis_in_Renal_Biopsies","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":87781646,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781646/thumbnails/1.jpg","file_name":"176.full.pdf","download_url":"https://www.academia.edu/attachments/87781646/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Morphometric_and_Visual_Evaluation_of_Fi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781646/176.full-libre.pdf?1655730471=\u0026response-content-disposition=attachment%3B+filename%3DMorphometric_and_Visual_Evaluation_of_Fi.pdf\u0026Expires=1733187491\u0026Signature=gW-kdy-XeQchQXVOWarxkDANqdHQJXcX66tObIqnaqeYZ25UUCkdoTFJP~fYqs-dBSLonPjEDIbOqByh-SpBdQPZ705w0V-v76t3yugHhyUhLbxFG3x5qXvn4tYf~55cZLwFWqHfsF0KGJpB5oF2qleyglbF~WW5Y7nt-QOtIyIrWHrT~sXPbpQ8AHq0xnEaBF1Jj-~dV2LTV1~dt6X~GYF-XuU-7KbdXUG0ygyB281G4aMDnkB-wpaMT6BpCnrj8ajVuXBfiutJ1tYU0WbZnM3W2BqAtVi92eerNfga8pFMFOf6oTFQuK0EOBnIuxZKUv6oqEekCSuCBhr9p3rLuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool"}],"urls":[{"id":21607919,"url":"https://syndication.highwire.org/content/doi/10.1681/ASN.2009091005"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81898811"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898811/Tubular_Expression_of_KIM_1_Does_not_Predict_Delayed_Function_After_Transplantation"><img alt="Research paper thumbnail of Tubular Expression of KIM-1 Does not Predict Delayed Function After Transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/87781663/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898811/Tubular_Expression_of_KIM_1_Does_not_Predict_Delayed_Function_After_Transplantation">Tubular Expression of KIM-1 Does not Predict Delayed Function After Transplantation</a></div><div class="wp-workCard_item"><span>Journal of the American Society of Nephrology</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5765b30798d58ac0029754ebf8ca181a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87781663,"asset_id":81898811,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87781663/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81898811"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81898811"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81898811; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=81898811]").text(description); $(".js-view-count[data-work-id=81898811]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 81898811; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='81898811']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 81898811, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5765b30798d58ac0029754ebf8ca181a" } } $('.js-work-strip[data-work-id=81898811]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":81898811,"title":"Tubular Expression of KIM-1 Does not Predict Delayed Function After Transplantation","translated_title":"","metadata":{"publisher":"American Society of Nephrology (ASN)","grobid_abstract":"Injured epithelial cells of the proximal tubule upregulate the glycoprotein kidney injury molecule 1 (KIM-1), suggesting its potential as a biomarker of incipient kidney allograft injury. It is unknown whether KIM-1 expression changes in kidney allografts with delayed graft function (DGF), which often follows ischemia-reperfusion injury. Here, we prospectively measured KIM-1 RNA and protein expression in preperfusion biopsies of 30 living-and 85 deceased-donor kidneys and correlated the results with histologic and clinical outcomes after transplantation. We detected KIM-1 expression in 62% of deceased-donor kidneys and only 13% of living-donor kidneys (P Ͻ 0.0001). The level of KIM-1 expression before reperfusion correlated inversely with renal function at the time of procurement and correlated directly with the degree of interstitial fibrosis. Surprising, however, we did not detect a significant correlation between KIM-1 staining intensity and the occurrence of DGF. Our findings are consistent with a role for KIM-1 as an early indicator of tubular injury but do not support tissue KIM-1 measurement before transplantation to identify kidneys at risk for DGF.","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"Journal of the American Society of Nephrology","grobid_abstract_attachment_id":87781663},"translated_abstract":null,"internal_url":"https://www.academia.edu/81898811/Tubular_Expression_of_KIM_1_Does_not_Predict_Delayed_Function_After_Transplantation","translated_internal_url":"","created_at":"2022-06-20T05:57:31.686-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":87781663,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781663/thumbnails/1.jpg","file_name":"536.full.pdf","download_url":"https://www.academia.edu/attachments/87781663/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tubular_Expression_of_KIM_1_Does_not_Pre.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781663/536.full-libre.pdf?1655730467=\u0026response-content-disposition=attachment%3B+filename%3DTubular_Expression_of_KIM_1_Does_not_Pre.pdf\u0026Expires=1733187491\u0026Signature=AHW8mI8H-s-3d-H3svIr8khxErn4ViTHaKS~zrx-U728RwD4WpohIw2opLVZDXhQ0N-bVcIBW-pZmPv0yybOP2tNRAKNdarh3PzjsJryplsNBg1pzxjaS6k1T1-AJkrPENmcmaNy~0elV1vyXPYm7YDMnzftn9vebdghfOE8YaIB8GM~I16ZrO7j0FG~tq8QwxBKrMThn1gRGsLjBiuVPv77D~9wdbeKSqav4Xy0Z17LGvhHAB50yKHQx8MQ490JEdLHXFXMkPpMiK-I-FkOuB3AaB0iX4j-EeCgh4ZCWT0PcGajG61hxsCTh5kb6Gyidna1DzYfrsavOiwRxiTrlQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Tubular_Expression_of_KIM_1_Does_not_Predict_Delayed_Function_After_Transplantation","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":87781663,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781663/thumbnails/1.jpg","file_name":"536.full.pdf","download_url":"https://www.academia.edu/attachments/87781663/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tubular_Expression_of_KIM_1_Does_not_Pre.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781663/536.full-libre.pdf?1655730467=\u0026response-content-disposition=attachment%3B+filename%3DTubular_Expression_of_KIM_1_Does_not_Pre.pdf\u0026Expires=1733187491\u0026Signature=AHW8mI8H-s-3d-H3svIr8khxErn4ViTHaKS~zrx-U728RwD4WpohIw2opLVZDXhQ0N-bVcIBW-pZmPv0yybOP2tNRAKNdarh3PzjsJryplsNBg1pzxjaS6k1T1-AJkrPENmcmaNy~0elV1vyXPYm7YDMnzftn9vebdghfOE8YaIB8GM~I16ZrO7j0FG~tq8QwxBKrMThn1gRGsLjBiuVPv77D~9wdbeKSqav4Xy0Z17LGvhHAB50yKHQx8MQ490JEdLHXFXMkPpMiK-I-FkOuB3AaB0iX4j-EeCgh4ZCWT0PcGajG61hxsCTh5kb6Gyidna1DzYfrsavOiwRxiTrlQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":622,"name":"Nephrology","url":"https://www.academia.edu/Documents/in/Nephrology"},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":247948,"name":"Cadaver","url":"https://www.academia.edu/Documents/in/Cadaver"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":794984,"name":"Reperfusion injury","url":"https://www.academia.edu/Documents/in/Reperfusion_injury"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests"},{"id":1663285,"name":"Delayed graft function","url":"https://www.academia.edu/Documents/in/Delayed_graft_function"}],"urls":[{"id":21607906,"url":"https://syndication.highwire.org/content/doi/10.1681/ASN.2009040390"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81898784"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898784/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation"><img alt="Research paper thumbnail of Clinical Utility of Liver Biopsy in Adults with Fontan Palliation" class="work-thumbnail" src="https://attachments.academia-assets.com/87781598/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898784/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation">Clinical Utility of Liver Biopsy in Adults with Fontan Palliation</a></div><div class="wp-workCard_item"><span>Journal of the American College of Cardiology</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8e61830444d216268eacac7558cab101" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87781598,"asset_id":81898784,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87781598/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81898784"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81898784"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81898784; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=81898784]").text(description); $(".js-view-count[data-work-id=81898784]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 81898784; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='81898784']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 81898784, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8e61830444d216268eacac7558cab101" } } $('.js-work-strip[data-work-id=81898784]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":81898784,"title":"Clinical Utility of Liver Biopsy in Adults with Fontan Palliation","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Background: Liver fibrosis is a common complication after Fontan palliation for single ventricle heart defects, but the clinical utility of liver biopsies is unclear. The purpose of this study was to determine if degree of liver fibrosis on biopsy correlates with clinical findings. methods: A chart review of adults with Fontan palliation and a liver biopsy at Emory's Adult Congenital Heart Center was performed (2001-2011). Core liver biopsies were examined using digitally scanned whole slide images of trichrome-stained sections. Portal and lobular fibrosis were quantitated using a positive pixel count algorithm tuned to detect fibrosis. Logistic regression and bivariate correlations were used to examine the relationship between fibrosis and ventricular dysfunction, IVC diameter, clinical features of portal hypertension (defined as ≥2 of the following: platelets \u003c150K, splenomegaly, varices, ascites), and adverse outcomes (death, transplant, or hepatocellular carcinoma [HCC]). results: Ten adults were identified (40% female, mean age 31±7 years). Mean time since Fontan was 18.6 years (range: 6-29), 7 had atriopulmonary connection of whom 4 underwent revision, 8 had a systemic left ventricle, 1 had ventricular dysfunction, and mean IVC diameter was 2.1 ± .23 cm. On biopsy, mean portal area was 1.4 x 105 ± 8.7 x 104 um2 and portal % fibrosis was 66% ± 16%. Mean lobular area was 5.9 x 105 ± 2.4 x 105 um2 and lobular % fibrosis was 20% ± 19%. Features of portal hypertension were present in 7, and 3 had an adverse outcome (death=1, transplant=1, HCC=1). No relationship was found between fibrosis and ventricular dysfunction (p=.26-.59), features of portal hypertension (p=.39-.98), or clinical outcomes (p=.14-.98). A strong positive correlation was found between mean portal area and time since Fontan (r= .82, p=.003) and a moderate trending correlation between portal % fibrosis and IVC diameter (r= .59, p=.07). conclusion: In adult patients following Fontan palliation, quantitative portal fibrosis by liver biopsy increases with time since surgery but does not correlate with clinical outcomes. Further evaluation in a larger population is needed to confirm these findings.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of the American College of Cardiology","grobid_abstract_attachment_id":87781598},"translated_abstract":null,"internal_url":"https://www.academia.edu/81898784/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation","translated_internal_url":"","created_at":"2022-06-20T05:57:19.160-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":87781598,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781598/thumbnails/1.jpg","file_name":"S0735-1097_2813_2960430-120220620-1-s1mbqe.pdf","download_url":"https://www.academia.edu/attachments/87781598/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Utility_of_Liver_Biopsy_in_Adul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781598/S0735-1097_2813_2960430-120220620-1-s1mbqe-libre.pdf?1655731083=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Utility_of_Liver_Biopsy_in_Adul.pdf\u0026Expires=1733187491\u0026Signature=frqzdjbr7W7pio1gZD1ZnRARypkjObT5hW2lj7X6Ehxcb4mhhNPkhTqMFy2K28yACog2UyXTp6PgdJoi0la1mfWGzd9m3qgft4lGwDJbzABfPXmhvU3aNMFNY8iwonqBrVFJCAVAuL4FcM-z2s~DNKMcwjv4Wzf0-d8Hhro0tu47VgmxlUYVdqSYtTPxMtSapnyrLF2sVPPq5GbESDpzzghg5Q1uJZPPJuPU0gLCR1R2V3wWXPCfVCE1aDxm9NNEX4s4Ayb-YKeyhrq7UvVAYqGlGnj5OgPvlHZfaFAB-AckJ756VleWRzngqOIqmzLRSexjmYiDkFx82RlVEEte5Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":87781598,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781598/thumbnails/1.jpg","file_name":"S0735-1097_2813_2960430-120220620-1-s1mbqe.pdf","download_url":"https://www.academia.edu/attachments/87781598/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Utility_of_Liver_Biopsy_in_Adul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781598/S0735-1097_2813_2960430-120220620-1-s1mbqe-libre.pdf?1655731083=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Utility_of_Liver_Biopsy_in_Adul.pdf\u0026Expires=1733187491\u0026Signature=frqzdjbr7W7pio1gZD1ZnRARypkjObT5hW2lj7X6Ehxcb4mhhNPkhTqMFy2K28yACog2UyXTp6PgdJoi0la1mfWGzd9m3qgft4lGwDJbzABfPXmhvU3aNMFNY8iwonqBrVFJCAVAuL4FcM-z2s~DNKMcwjv4Wzf0-d8Hhro0tu47VgmxlUYVdqSYtTPxMtSapnyrLF2sVPPq5GbESDpzzghg5Q1uJZPPJuPU0gLCR1R2V3wWXPCfVCE1aDxm9NNEX4s4Ayb-YKeyhrq7UvVAYqGlGnj5OgPvlHZfaFAB-AckJ756VleWRzngqOIqmzLRSexjmYiDkFx82RlVEEte5Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81898762"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898762/Eosinophilic_granulomatous_gastrointestinal_and_hepatic_abscesses_attributable_to_basidiobolomycosis_and_fasciolias_a_simultaneous_emergence_in_Iraqi_Kurdistan"><img alt="Research paper thumbnail of Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan" class="work-thumbnail" src="https://attachments.academia-assets.com/87781554/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898762/Eosinophilic_granulomatous_gastrointestinal_and_hepatic_abscesses_attributable_to_basidiobolomycosis_and_fasciolias_a_simultaneous_emergence_in_Iraqi_Kurdistan">Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan</a></div><div class="wp-workCard_item"><span>BMC Infectious Diseases</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Deep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutan...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Deep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutaneous abscesses, are rare. Most reports are from the Far-East and India where the most commonly attributed cause is Toxocara. Sulaimaniyah in Northeastern Iraq has experienced an outbreak of eosinophilic granulomatous liver and gastrointestinal (GI) abscesses beginning in 2009. The purpose of this study was to determine the etiology and guide treatment. Methods The study was an ongoing investigation of patients having a histopathologic diagnosis of eosinophilic granulomatous abdominal abscesses in Sulaimaniyah hospitals from May 2009 to August 2012. Tissues were examined for organisms, and Enzyme Linked Immunoabsorbent Assays (ELISA) were performed for serum antibodies to Fasciola hepatica, Toxocara, and Echinococcus granulosus. Results Fourteen patients had granulomatous inflammation surrounding a central necrotizing eosinophilic exudate identified in surgical pathology specimens from ab...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="807bb4a015e2c347f2549579fa7512d8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87781554,"asset_id":81898762,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87781554/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81898762"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81898762"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81898762; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=81898762]").text(description); $(".js-view-count[data-work-id=81898762]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 81898762; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='81898762']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 81898762, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "807bb4a015e2c347f2549579fa7512d8" } } $('.js-work-strip[data-work-id=81898762]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":81898762,"title":"Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan","translated_title":"","metadata":{"abstract":"Background Deep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutaneous abscesses, are rare. Most reports are from the Far-East and India where the most commonly attributed cause is Toxocara. Sulaimaniyah in Northeastern Iraq has experienced an outbreak of eosinophilic granulomatous liver and gastrointestinal (GI) abscesses beginning in 2009. The purpose of this study was to determine the etiology and guide treatment. Methods The study was an ongoing investigation of patients having a histopathologic diagnosis of eosinophilic granulomatous abdominal abscesses in Sulaimaniyah hospitals from May 2009 to August 2012. Tissues were examined for organisms, and Enzyme Linked Immunoabsorbent Assays (ELISA) were performed for serum antibodies to Fasciola hepatica, Toxocara, and Echinococcus granulosus. Results Fourteen patients had granulomatous inflammation surrounding a central necrotizing eosinophilic exudate identified in surgical pathology specimens from ab...","publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"BMC Infectious Diseases"},"translated_abstract":"Background Deep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutaneous abscesses, are rare. Most reports are from the Far-East and India where the most commonly attributed cause is Toxocara. Sulaimaniyah in Northeastern Iraq has experienced an outbreak of eosinophilic granulomatous liver and gastrointestinal (GI) abscesses beginning in 2009. The purpose of this study was to determine the etiology and guide treatment. Methods The study was an ongoing investigation of patients having a histopathologic diagnosis of eosinophilic granulomatous abdominal abscesses in Sulaimaniyah hospitals from May 2009 to August 2012. Tissues were examined for organisms, and Enzyme Linked Immunoabsorbent Assays (ELISA) were performed for serum antibodies to Fasciola hepatica, Toxocara, and Echinococcus granulosus. Results Fourteen patients had granulomatous inflammation surrounding a central necrotizing eosinophilic exudate identified in surgical pathology specimens from ab...","internal_url":"https://www.academia.edu/81898762/Eosinophilic_granulomatous_gastrointestinal_and_hepatic_abscesses_attributable_to_basidiobolomycosis_and_fasciolias_a_simultaneous_emergence_in_Iraqi_Kurdistan","translated_internal_url":"","created_at":"2022-06-20T05:57:00.352-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":87781554,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781554/thumbnails/1.jpg","file_name":"1471-2334-13-91.pdf","download_url":"https://www.academia.edu/attachments/87781554/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Eosinophilic_granulomatous_gastrointesti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781554/1471-2334-13-91-libre.pdf?1655731092=\u0026response-content-disposition=attachment%3B+filename%3DEosinophilic_granulomatous_gastrointesti.pdf\u0026Expires=1733187491\u0026Signature=B1Kti4j0AKrHSGPLdrWJsjvzownqAsl3rieMwH7uCdv8fqGi0M72LkdjHNGfDvFlB5YHsD0sOxfp4wBCnSG0Hfkf~gQCyaMDdqWIPNe1DBTPElfDYsQesu5MY86fi632nt3HgxHP2HXC-xN-hqnCZN6oAAf21BS0hbxV6DQ49sYwSN0kXzAxqKI4n3rwHzfgjCkM6pW7F48zrETpWsfMYWUhZNqSxJX1GZI5jEsZofZr1MW2dWP0BEcPScaJRLG1mvdJe6ExsIjHIgrWYNyxKZGktOoJmCdGDwYfxQJZ8tbcJRSf8fOT7~BiKW7ZAsnRrzNrGooNJuoZfCxT-KF9Sw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Eosinophilic_granulomatous_gastrointestinal_and_hepatic_abscesses_attributable_to_basidiobolomycosis_and_fasciolias_a_simultaneous_emergence_in_Iraqi_Kurdistan","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":87781554,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781554/thumbnails/1.jpg","file_name":"1471-2334-13-91.pdf","download_url":"https://www.academia.edu/attachments/87781554/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Eosinophilic_granulomatous_gastrointesti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781554/1471-2334-13-91-libre.pdf?1655731092=\u0026response-content-disposition=attachment%3B+filename%3DEosinophilic_granulomatous_gastrointesti.pdf\u0026Expires=1733187491\u0026Signature=B1Kti4j0AKrHSGPLdrWJsjvzownqAsl3rieMwH7uCdv8fqGi0M72LkdjHNGfDvFlB5YHsD0sOxfp4wBCnSG0Hfkf~gQCyaMDdqWIPNe1DBTPElfDYsQesu5MY86fi632nt3HgxHP2HXC-xN-hqnCZN6oAAf21BS0hbxV6DQ49sYwSN0kXzAxqKI4n3rwHzfgjCkM6pW7F48zrETpWsfMYWUhZNqSxJX1GZI5jEsZofZr1MW2dWP0BEcPScaJRLG1mvdJe6ExsIjHIgrWYNyxKZGktOoJmCdGDwYfxQJZ8tbcJRSf8fOT7~BiKW7ZAsnRrzNrGooNJuoZfCxT-KF9Sw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":11589,"name":"Iraq","url":"https://www.academia.edu/Documents/in/Iraq"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle"},{"id":988280,"name":"Abscess","url":"https://www.academia.edu/Documents/in/Abscess"},{"id":2430299,"name":"Gastrointestinal Diseases","url":"https://www.academia.edu/Documents/in/Gastrointestinal_Diseases"},{"id":2756122,"name":"Fascioliasis","url":"https://www.academia.edu/Documents/in/Fascioliasis"},{"id":3238443,"name":"eosinophilic granuloma","url":"https://www.academia.edu/Documents/in/eosinophilic_granuloma"}],"urls":[{"id":21607885,"url":"http://link.springer.com/content/pdf/10.1186/1471-2334-13-91.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81898754"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898754/Acute_Renal_Endothelial_Injury_During_Marrow_Recovery_in_a_Cohort_of_Combined_Kidney_and_Bone_Marrow_Allografts"><img alt="Research paper thumbnail of Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts" class="work-thumbnail" src="https://attachments.academia-assets.com/87781581/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898754/Acute_Renal_Endothelial_Injury_During_Marrow_Recovery_in_a_Cohort_of_Combined_Kidney_and_Bone_Marrow_Allografts">Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts</a></div><div class="wp-workCard_item"><span>American Journal of Transplantation</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f42df84221a0c23f65ba24edf621d23" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87781581,"asset_id":81898754,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87781581/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81898754"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81898754"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81898754; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4f42df84221a0c23f65ba24edf621d23" } } $('.js-work-strip[data-work-id=81898754]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":81898754,"title":"Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts","translated_title":"","metadata":{"publisher":"Wiley-Blackwell","grobid_abstract":"An idiopathic capillary leak syndrome (\"engraftment syndrome\") often occurs in recipients of hematopoietic cells, manifested clinically by transient azotemia and sometimes fever and fluid retention. Here we report the renal pathology in 10 recipients of combined bone marrow and kidney allografts. Nine developed graft dysfunction on day 10-16 and renal biopsies showed marked acute tubular injury, with interstitial edema, hemorrhage and capillary congestion, with little or no interstitial infiltrate (≤10%) and marked glomerular and peritubular capillary (PTC) endothelial injury and loss by electron microscopy. Two had transient arterial endothelial inflammation; and 2 had C4d deposition. The cells in capillaries were primarily CD68 + MPO + mononuclear cells and CD3 + CD8 + T cells, the latter with a high proliferative index (Ki67 +). B cells (CD20 +) and CD4 + T cells were not detectable, and NK cells were rare. XY FISH showed that CD45 + cells in PTCs were of recipient origin. Optimal treatment remains to be defined; two recovered without additional therapy, six were treated with anti-rejection regimens. Except for one patient, who later developed thrombotic microangiopathy and one with acute humoral rejection, all fully recovered within 2-4 weeks. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81898741"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898741/Development_of_focal_segmental_glomerulosclerosis_in_the_renal_allograft_of_a_patient_with_lupus"><img alt="Research paper thumbnail of Development of focal segmental glomerulosclerosis in the renal allograft of a patient with lupus" class="work-thumbnail" src="https://attachments.academia-assets.com/87781577/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898741/Development_of_focal_segmental_glomerulosclerosis_in_the_renal_allograft_of_a_patient_with_lupus">Development of focal segmental glomerulosclerosis in the renal allograft of a patient with lupus</a></div><div class="wp-workCard_item"><span>American Journal of Kidney Diseases</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f083d5b29a08a94a24bc63951bd4b067" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87781577,"asset_id":81898741,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87781577/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81898741"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81898741"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81898741; 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This study aimed to develop patient-reported outcome questionnaires to measure patient experiences related to FSGS. Study Design: Qualitative patient interviews to identify important symptoms and concepts (concept elicitation) formed the basis for the development of 2 questionnaires, one on symptoms and one on their impact. Additional qualitative interviews were implemented to evaluate/refine the questionnaires (cognitive debriefing). Transcripts of concept elicitation and cognitive debriefing interviews, conducted by telephone, were analyzed for concepts of interest using qualitative text analysis. Setting \u0026 Participants: Patients with FSGS (aged 18-65 years with estimated glomerular filtration rates $ 40 mL/min/1.73 m 2) whose disease remained inadequately controlled after 2 or fewer courses of treatment. Methodology: Qualitative concept elicitation and cognitive debriefing interviews. Analytical Approach: Interview transcripts were analyzed using qualitative software, MAXQDA. Results: 30 patients completed concept elicitation interviews; 9 patients completed cognitive debriefing interviews. Frequently mentioned symptoms included swelling from the waist down/legs/knees/feet/ankles (67%), fatigue (57%), stomach/abdomen swelling (43%), body pain/pressure (30%), and shortness of breath (20%), as well as impacts on physical (52%), emotional (68%), and social functioning (89%). Based on analyses of interview transcripts and clinical input, 2 questionnaires, one on symptoms and one on the impact of the symptom, were drafted. The 23-item FSGS Symptom Diary (assessing the frequency and severity of FSGS symptoms during the past 24 hours) and the FSGS Symptom Impact Questionnaire (17 items assessing interference with activities and emotions during the past 7 days) were iteratively revised based on cognitive debriefing interviews. Limitations: The study was restricted to English-speaking adults located in the United States, and the concept elicitation interview group had a low number of African Americans. Conclusions: The FSGS Symptom Diary and FSGS Symptom Impact Questionnaire are new FSGSspecific patient-reported outcomes measures designed to support a comprehensive assessment of symptoms and symptom impact in adults with FSGS. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4758293" id="papers"><div class="js-work-strip profile--work_container" data-work-id="124810408"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124810408/Artificial_intelligence_based_liver_portal_tract_region_identification_and_quantification_with_transplant_biopsy_whole_slide_images"><img alt="Research paper thumbnail of Artificial intelligence based liver portal tract region identification and quantification with transplant biopsy whole-slide images" class="work-thumbnail" src="https://attachments.academia-assets.com/118967111/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124810408/Artificial_intelligence_based_liver_portal_tract_region_identification_and_quantification_with_transplant_biopsy_whole_slide_images">Artificial intelligence based liver portal tract region identification and quantification with transplant biopsy whole-slide images</a></div><div class="wp-workCard_item"><span>Computers in Biology and Medicine</span><span>, Nov 1, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb7339b26ae60bc144a2163f05654ba5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118967111,"asset_id":124810408,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118967111/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124810408"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124810408"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124810408; 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As the portal tract fibrotic quantity and size in a liver biopsy correlate with the fibrosis stage, an accurate analysis of portal tract regions is clinically critical. Manual annotations of portal tract regions, however, are time-consuming and subject to large inter-and intra-observer variability. To address such a challenge, we develop a Multiple Up-sampling and Spatial Attention guided UNet model (MUSA-UNet) to segment liver portal tract regions in whole-slide images of liver tissue slides. To enhance the segmentation performance, we propose to use depth-wise separable convolution, the spatial attention mechanism, the residual connection, and multiple up-sampling paths in the developed model. This study includes 53 histopathology whole slide images from patients who received liver transplantation. In total, 6,012 patches derived from 30 images are used for our deep learning model training and validation. The remaining 23 whole slide images are utilized for the model testing. The average liver portal tract segmentation performance of the developed MUSA-UNet is 0.94 (Precision), 0.85 (Recall), 0.89 (F1 Score), 0.89 (Accuracy), 0.80 (Jaccard Index), and 0.91 (Fowlkes-Mallows Index), respectively. The clinical Scheuer fibrosis stage presents a strong correlation with the resulting average portal tract fibrotic area (R=0.681, p\u003c0.001) and portal tract percentage (R=0.335, p=0.02) computed from the MUSA-UNet segmentation results. In conclusion, our developed deep learning model MUSA-UNet can accurately segment portal tract regions from whole-slide images of liver tissue biopsies, presenting its promising potential to assist liver disease diagnosis in a computational manner.","publication_date":{"day":1,"month":11,"year":2022,"errors":{}},"publication_name":"Computers in Biology and 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by digital image analysis reveals correlation with qualitative clinical fibrosis staging in liver transplant patients" class="work-thumbnail" src="https://attachments.academia-assets.com/118967125/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124810407/Quantitative_assessment_of_liver_fibrosis_by_digital_image_analysis_reveals_correlation_with_qualitative_clinical_fibrosis_staging_in_liver_transplant_patients">Quantitative assessment of liver fibrosis by digital image analysis reveals correlation with qualitative clinical fibrosis staging in liver transplant patients</a></div><div class="wp-workCard_item"><span>PLOS ONE</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a 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124810407, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e9528b7d6a535868718831ea0a9c86c6" } } $('.js-work-strip[data-work-id=124810407]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124810407,"title":"Quantitative assessment of liver fibrosis by digital image analysis reveals correlation with qualitative clinical fibrosis staging in liver transplant patients","translated_title":"","metadata":{"publisher":"Public Library of Science (PLoS)","grobid_abstract":"Technologies for digitizing tissues provide important quantitative data for liver histopathology investigation. We aimed to assess liver fibrosis degree with quantitative morphometric measurements of histopathological sections utilizing digital image analysis (DIA) and to further investigate if a correlation with histopathologic scoring (Scheuer staging) exists. A retrospective study of patients with at least two post-liver transplant biopsies having a Scheuer stage of � 2 at baseline were gathered. Portal tract fibrotic percentage (%) and size (μm 2) were measured by DIA, while clinical fibrosis score was measured by the Scheuer system. Correlations between DIA measurements and Scheuer scores were computed by Spearman correlation analysis. Differences between mean levels of fibrosis (score, size, and percentage) at baseline versus second visit were computed by Student's t-test. P values \u003c 0.05 were considered significant. Of 22 patients who met the study criteria, 54 biopsies were included for analysis. Average levels ±standard error [S.E.] of portal tract fibrotic percentage (%) and size (μm 2) progressed from 46.5 ± 3.6% at baseline to 61.8 ± 3.8% at the second visit (P = 0.005 by Student's t-test), and from 28,075 ± 3,232 μm 2 at base line to 67,146 ± 10,639 μm 2 at the second visit (P = 0.002 by Student's t-test), respectively. Average levels of Scheuer fibrosis scores progressed from 0.55±0.19 at baseline to 1.14±0.26 at the second visit (P = 0.02 by Student's t-test). Portal tract fibrotic percentage (%) and portal tract fibrotic size were directly correlated with clinical Scheuer fibrosis stage, with Spearman correlation coefficient and P value computed as r = 0.70, P \u003c 0.0001 and r = 0.41, P = 0.002, respectively. Digital quantitative assessment of portal triad size and fibrosis percentage demonstrates a strong correlation with visually assessed histologic stage of liver fibrosis","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"PLOS ONE","grobid_abstract_attachment_id":118967125},"translated_abstract":null,"internal_url":"https://www.academia.edu/124810407/Quantitative_assessment_of_liver_fibrosis_by_digital_image_analysis_reveals_correlation_with_qualitative_clinical_fibrosis_staging_in_liver_transplant_patients","translated_internal_url":"","created_at":"2024-10-17T08:01:38.501-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":118967125,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/118967125/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/118967125/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Quantitative_assessment_of_liver_fibrosi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/118967125/pdf-libre.pdf?1729179322=\u0026response-content-disposition=attachment%3B+filename%3DQuantitative_assessment_of_liver_fibrosi.pdf\u0026Expires=1733187490\u0026Signature=cqMp2SE7hP0HLnkFoDofTHN4mUA332LASIwM9qi4sOL5NU9Ef~cJmjt12o0Y-inmDpyHXNoMdOCN-fgZNAdH2JnNLf4bVm3WT5gRdnKO~0PblWnDohhCf9j~9PFqXr06DuZ33qsXivVgeo~-X-aBSMpFVzMlA91ZtKQ540cldq5dv5rgJEYGRUWeeBV9e3lWKOg-6eikBbnSqdKVselnXnjUZP3Jei9wBTItLmxatp750BCxSCAnm7ub8eQPHyyTFNuS~-LuB2wcLrXzcqgUQYWIctfj5j9AESvfD5KDnDR~igTBb7p6XkRqBZypaoaUJaAYb9fkqu8ajJBsi-Ya6Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Quantitative_assessment_of_liver_fibrosis_by_digital_image_analysis_reveals_correlation_with_qualitative_clinical_fibrosis_staging_in_liver_transplant_patients","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":118967125,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/118967125/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/118967125/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Quantitative_assessment_of_liver_fibrosi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/118967125/pdf-libre.pdf?1729179322=\u0026response-content-disposition=attachment%3B+filename%3DQuantitative_assessment_of_liver_fibrosi.pdf\u0026Expires=1733187490\u0026Signature=cqMp2SE7hP0HLnkFoDofTHN4mUA332LASIwM9qi4sOL5NU9Ef~cJmjt12o0Y-inmDpyHXNoMdOCN-fgZNAdH2JnNLf4bVm3WT5gRdnKO~0PblWnDohhCf9j~9PFqXr06DuZ33qsXivVgeo~-X-aBSMpFVzMlA91ZtKQ540cldq5dv5rgJEYGRUWeeBV9e3lWKOg-6eikBbnSqdKVselnXnjUZP3Jei9wBTItLmxatp750BCxSCAnm7ub8eQPHyyTFNuS~-LuB2wcLrXzcqgUQYWIctfj5j9AESvfD5KDnDR~igTBb7p6XkRqBZypaoaUJaAYb9fkqu8ajJBsi-Ya6Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3274,"name":"Gastroenterology","url":"https://www.academia.edu/Documents/in/Gastroenterology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":76863,"name":"Histopathology","url":"https://www.academia.edu/Documents/in/Histopathology"},{"id":125176,"name":"Liver Fibrosis","url":"https://www.academia.edu/Documents/in/Liver_Fibrosis"},{"id":126289,"name":"Digital Image Analysis","url":"https://www.academia.edu/Documents/in/Digital_Image_Analysis"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"}],"urls":[{"id":45199406,"url":"https://dx.plos.org/10.1371/journal.pone.0239624"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124810405"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124810405/Evidence_for_Kidney_Rejection_After_Combined_Bone_Marrow_and_Renal_Transplantation_Despite_Ongoing_Whole_Blood_Chimerism_in_Rhesus_Macaques"><img alt="Research paper thumbnail of Evidence for Kidney Rejection After Combined Bone Marrow and Renal Transplantation Despite Ongoing Whole-Blood Chimerism in Rhesus Macaques" class="work-thumbnail" src="https://attachments.academia-assets.com/118967109/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124810405/Evidence_for_Kidney_Rejection_After_Combined_Bone_Marrow_and_Renal_Transplantation_Despite_Ongoing_Whole_Blood_Chimerism_in_Rhesus_Macaques">Evidence for Kidney Rejection After Combined Bone Marrow and Renal Transplantation Despite Ongoing Whole-Blood Chimerism in Rhesus Macaques</a></div><div class="wp-workCard_item"><span>American Journal of Transplantation</span><span>, Jul 1, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="323838c5a329dd01f66254f867c15465" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118967109,"asset_id":124810405,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118967109/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124810405"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124810405"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124810405; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124810405]").text(description); $(".js-view-count[data-work-id=124810405]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124810405; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124810405']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 124810405, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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To address this, we used an MHC-defined primate model to determine the impact of impermanent, T cell-poor, mixed-chimerism on renal allograft survival. We compared two cohorts: one receiving a bone marrow + renal transplant (\"BMT/renal\") and one receiving only a renal transplant. Both cohorts received maintenance immunosuppression with CD28/CD40directed costimulation blockade and sirolimus. As previously demonstrated, this transplant strategy consistently induced compartmentalized donor chimerism, (significant whole-blood chimerism, lacking T cell chimerism). This chimerism was not sufficient to prolong renal allograft acceptance: the BMT/renal mean survival time (MST, 76 days) was not significantly different than the renal transplant alone MST (85 days, p= 0. 46), with histopathology documenting T-cell mediated rejection. Flow cytometric analysis revealed significant enrichment for CD28-/CD95+ CD4+ and CD8+ Tem cells in the rejected kidney, suggesting a link between CD28-negative Tem and costimulation blockade-resistant rejection. These results suggest that in some settings, transient T cell-poor chimerism is not sufficient to induce tolerance to a concurrently placed renal allograft and that the presence of this chimerism per se is not an independent biomarker to identify tolerance.","publication_date":{"day":1,"month":7,"year":2012,"errors":{}},"publication_name":"American Journal of 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transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression"},{"id":214902,"name":"Chimerism","url":"https://www.academia.edu/Documents/in/Chimerism"},{"id":338534,"name":"Biomarker","url":"https://www.academia.edu/Documents/in/Biomarker"},{"id":354937,"name":"Bone Marrow Transplantation","url":"https://www.academia.edu/Documents/in/Bone_Marrow_Transplantation"},{"id":573267,"name":"Macaca Mulatta","url":"https://www.academia.edu/Documents/in/Macaca_Mulatta"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":45199405,"url":"https://europepmc.org/articles/pmc3387328?pdf=render"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114997747"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114997747/Beyond_a_Broken_Heart_Circulatory_Dysfunction_in_the_Failing_Fontan"><img alt="Research paper thumbnail of Beyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114997747/Beyond_a_Broken_Heart_Circulatory_Dysfunction_in_the_Failing_Fontan">Beyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan</a></div><div class="wp-workCard_item"><span>Pediatric Cardiology</span><span>, Feb 15, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has been described previously. However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ventricular function. The clinical deterioration in patients who have undergone Fontan palliation requires a broader view of circulatory dysfunction, one that takes into account the complex interaction of regulatory systems affecting hepatic, renal, and pulmonary blood flow, in addition to cardiac function. This review focuses primarily on the pathophysiology of multiple organ involvement in this circulatory dysfunction, with particular focus on the consequences of hepatic dysfunction and portal hypertension. The authors discuss hepatic perfusion, both in health and disease, and review the current understanding of liver histopathology and liver disease in adult Fontan patients and similar clinicopathologic states. They compare and contrast features of postsinusoidal portal hypertension with more typical adult cirrhotic disease. Finally, they delineate the related effects of portal hypertensive physiology on the systemic and pulmonary vasculature, the kidney, and the heart itself and discuss how these changes affect the care of the adult Fontan patient.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114997747"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114997747"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114997747; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114997747]").text(description); $(".js-view-count[data-work-id=114997747]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114997747; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114997747']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114997747, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114997747]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114997747,"title":"Beyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan","translated_title":"","metadata":{"abstract":"The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has been described previously. However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ventricular function. The clinical deterioration in patients who have undergone Fontan palliation requires a broader view of circulatory dysfunction, one that takes into account the complex interaction of regulatory systems affecting hepatic, renal, and pulmonary blood flow, in addition to cardiac function. This review focuses primarily on the pathophysiology of multiple organ involvement in this circulatory dysfunction, with particular focus on the consequences of hepatic dysfunction and portal hypertension. The authors discuss hepatic perfusion, both in health and disease, and review the current understanding of liver histopathology and liver disease in adult Fontan patients and similar clinicopathologic states. They compare and contrast features of postsinusoidal portal hypertension with more typical adult cirrhotic disease. Finally, they delineate the related effects of portal hypertensive physiology on the systemic and pulmonary vasculature, the kidney, and the heart itself and discuss how these changes affect the care of the adult Fontan patient.","publisher":"Springer Science+Business Media","publication_date":{"day":15,"month":2,"year":2014,"errors":{}},"publication_name":"Pediatric Cardiology"},"translated_abstract":"The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has been described previously. However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ventricular function. The clinical deterioration in patients who have undergone Fontan palliation requires a broader view of circulatory dysfunction, one that takes into account the complex interaction of regulatory systems affecting hepatic, renal, and pulmonary blood flow, in addition to cardiac function. This review focuses primarily on the pathophysiology of multiple organ involvement in this circulatory dysfunction, with particular focus on the consequences of hepatic dysfunction and portal hypertension. The authors discuss hepatic perfusion, both in health and disease, and review the current understanding of liver histopathology and liver disease in adult Fontan patients and similar clinicopathologic states. They compare and contrast features of postsinusoidal portal hypertension with more typical adult cirrhotic disease. Finally, they delineate the related effects of portal hypertensive physiology on the systemic and pulmonary vasculature, the kidney, and the heart itself and discuss how these changes affect the care of the adult Fontan patient.","internal_url":"https://www.academia.edu/114997747/Beyond_a_Broken_Heart_Circulatory_Dysfunction_in_the_Failing_Fontan","translated_internal_url":"","created_at":"2024-02-16T11:28:22.102-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Beyond_a_Broken_Heart_Circulatory_Dysfunction_in_the_Failing_Fontan","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology"},{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension"},{"id":37788,"name":"Pediatric Cardiology","url":"https://www.academia.edu/Documents/in/Pediatric_Cardiology"},{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71342,"name":"Portal hypertension","url":"https://www.academia.edu/Documents/in/Portal_hypertension"},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate"},{"id":1154249,"name":"Heart Ventricles","url":"https://www.academia.edu/Documents/in/Heart_Ventricles"},{"id":3306139,"name":"Treatment Failure","url":"https://www.academia.edu/Documents/in/Treatment_Failure"},{"id":3378593,"name":"Fontan procedure","url":"https://www.academia.edu/Documents/in/Fontan_procedure"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":39523524,"url":"https://doi.org/10.1007/s00246-014-0881-y"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114997746"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114997746/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation"><img alt="Research paper thumbnail of Clinical Utility of Liver Biopsy in Adults with Fontan Palliation" class="work-thumbnail" src="https://attachments.academia-assets.com/111535315/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114997746/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation">Clinical Utility of Liver Biopsy in Adults with Fontan Palliation</a></div><div class="wp-workCard_item"><span>Journal of the American College of Cardiology</span><span>, Mar 1, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1e8fae0d952f332d3529fcea8ee96ebf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111535315,"asset_id":114997746,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111535315/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114997746"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114997746"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114997746; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114997746]").text(description); $(".js-view-count[data-work-id=114997746]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114997746; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114997746']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114997746, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1e8fae0d952f332d3529fcea8ee96ebf" } } $('.js-work-strip[data-work-id=114997746]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114997746,"title":"Clinical Utility of Liver Biopsy in Adults with Fontan Palliation","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Background: Liver fibrosis is a common complication after Fontan palliation for single ventricle heart defects, but the clinical utility of liver biopsies is unclear. The purpose of this study was to determine if degree of liver fibrosis on biopsy correlates with clinical findings. methods: A chart review of adults with Fontan palliation and a liver biopsy at Emory's Adult Congenital Heart Center was performed (2001-2011). Core liver biopsies were examined using digitally scanned whole slide images of trichrome-stained sections. Portal and lobular fibrosis were quantitated using a positive pixel count algorithm tuned to detect fibrosis. Logistic regression and bivariate correlations were used to examine the relationship between fibrosis and ventricular dysfunction, IVC diameter, clinical features of portal hypertension (defined as ≥2 of the following: platelets \u003c150K, splenomegaly, varices, ascites), and adverse outcomes (death, transplant, or hepatocellular carcinoma [HCC]). results: Ten adults were identified (40% female, mean age 31±7 years). Mean time since Fontan was 18.6 years (range: 6-29), 7 had atriopulmonary connection of whom 4 underwent revision, 8 had a systemic left ventricle, 1 had ventricular dysfunction, and mean IVC diameter was 2.1 ± .23 cm. On biopsy, mean portal area was 1.4 x 105 ± 8.7 x 104 um2 and portal % fibrosis was 66% ± 16%. Mean lobular area was 5.9 x 105 ± 2.4 x 105 um2 and lobular % fibrosis was 20% ± 19%. Features of portal hypertension were present in 7, and 3 had an adverse outcome (death=1, transplant=1, HCC=1). No relationship was found between fibrosis and ventricular dysfunction (p=.26-.59), features of portal hypertension (p=.39-.98), or clinical outcomes (p=.14-.98). A strong positive correlation was found between mean portal area and time since Fontan (r= .82, p=.003) and a moderate trending correlation between portal % fibrosis and IVC diameter (r= .59, p=.07). conclusion: In adult patients following Fontan palliation, quantitative portal fibrosis by liver biopsy increases with time since surgery but does not correlate with clinical outcomes. Further evaluation in a larger population is needed to confirm these findings.","publication_date":{"day":1,"month":3,"year":2013,"errors":{}},"publication_name":"Journal of the American College of Cardiology","grobid_abstract_attachment_id":111535315},"translated_abstract":null,"internal_url":"https://www.academia.edu/114997746/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation","translated_internal_url":"","created_at":"2024-02-16T11:28:21.548-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":111535315,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111535315/thumbnails/1.jpg","file_name":"S0735-109728132960430-120240216-1-jsq9zu.pdf","download_url":"https://www.academia.edu/attachments/111535315/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Utility_of_Liver_Biopsy_in_Adul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111535315/S0735-109728132960430-120240216-1-jsq9zu-libre.pdf?1708113406=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Utility_of_Liver_Biopsy_in_Adul.pdf\u0026Expires=1733187490\u0026Signature=AIyv-dkLLt5UU35-Esg7PMVZxUeiW~4cCT9WYeuNqQ9qGudluwGnUE951yXWqLmkze7FWZm9Dl0AaitvQRI~9cCM8BTx0AKxyihYw5dY~nutR9zY~EBMLmr27Jk6kz1qiPhOpWio5R2NAdiLOoaqALNK3MrUgF6IEKIHzBAcL66UvEsJQHVrBp0yMad67zbi5jqB2bPRxVuUbNMFegaeCLdmwFNN-kLJF7LbpieQM82kRad2qq~vIrKUVYVoCpXUDpScmBkECKwc3LJ5FAQOQaNgtjP2iyiXn76wQmMYTRgg-Nt1fpyjd2nfibvL3aPKhquOvVQ2pn8v4aCfB7k~Ew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":111535315,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111535315/thumbnails/1.jpg","file_name":"S0735-109728132960430-120240216-1-jsq9zu.pdf","download_url":"https://www.academia.edu/attachments/111535315/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Utility_of_Liver_Biopsy_in_Adul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111535315/S0735-109728132960430-120240216-1-jsq9zu-libre.pdf?1708113406=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Utility_of_Liver_Biopsy_in_Adul.pdf\u0026Expires=1733187490\u0026Signature=AIyv-dkLLt5UU35-Esg7PMVZxUeiW~4cCT9WYeuNqQ9qGudluwGnUE951yXWqLmkze7FWZm9Dl0AaitvQRI~9cCM8BTx0AKxyihYw5dY~nutR9zY~EBMLmr27Jk6kz1qiPhOpWio5R2NAdiLOoaqALNK3MrUgF6IEKIHzBAcL66UvEsJQHVrBp0yMad67zbi5jqB2bPRxVuUbNMFegaeCLdmwFNN-kLJF7LbpieQM82kRad2qq~vIrKUVYVoCpXUDpScmBkECKwc3LJ5FAQOQaNgtjP2iyiXn76wQmMYTRgg-Nt1fpyjd2nfibvL3aPKhquOvVQ2pn8v4aCfB7k~Ew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":3752221,"name":"Liver biopsy","url":"https://www.academia.edu/Documents/in/Liver_biopsy"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":39523523,"url":"https://doi.org/10.1016/s0735-1097(13)60430-1"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114997744"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114997744/PRO_C3_a_Serological_Marker_of_Fibrosis_During_Childhood_and_Correlations_With_Fibrosis_in_Pediatric_NAFLD"><img alt="Research paper thumbnail of PRO‐C3, a Serological Marker of Fibrosis, During Childhood and Correlations With Fibrosis in Pediatric NAFLD" class="work-thumbnail" src="https://attachments.academia-assets.com/111535314/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114997744/PRO_C3_a_Serological_Marker_of_Fibrosis_During_Childhood_and_Correlations_With_Fibrosis_in_Pediatric_NAFLD">PRO‐C3, a Serological Marker of Fibrosis, During Childhood and Correlations With Fibrosis in Pediatric NAFLD</a></div><div class="wp-workCard_item"><span>Hepatology Communications</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease in children and may le...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease in children and may lead to cirrhosis requiring liver transplant. Thus, prompt diagnosis of advanced fibrosis is essential. Our objectives were to examine PRO‐C3 (a neo‐epitope pro‐peptide of type III collagen formation) levels across childhood/adolescence and associations with advanced fibrosis in pediatric NAFLD. This cross‐sectional study included 88 children and adolescents with biopsy‐proven NAFLD (mean age: 13.9 ± 2.9 years, 71% male) and 65 healthy participants (11.8 ± 4.5 years, 38% male). PRO‐C3, and the bone remodeling biomarkers C‐terminal telopeptide of type I collagen (CTX‐I; bone resorption) and osteocalcin (N‐MID; bone formation), were measured in serum by enzyme‐linked immunosorbent assay. Fibrosis was assessed by liver biopsy in participants with NAFLD, who were categorized as having advanced (Ishak score ≥ 3) or none/mild fibrosis (Ishak score ≤ 2). Overall, PRO‐C3 was similar in participant...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b09789a1f43b5d4cc130d5e1a8b96be2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111535314,"asset_id":114997744,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111535314/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114997744"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114997744"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114997744; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114997744]").text(description); $(".js-view-count[data-work-id=114997744]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114997744; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114997744']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114997744, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b09789a1f43b5d4cc130d5e1a8b96be2" } } $('.js-work-strip[data-work-id=114997744]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114997744,"title":"PRO‐C3, a Serological Marker of Fibrosis, During Childhood and Correlations With Fibrosis in Pediatric NAFLD","translated_title":"","metadata":{"abstract":"Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease in children and may lead to cirrhosis requiring liver transplant. Thus, prompt diagnosis of advanced fibrosis is essential. Our objectives were to examine PRO‐C3 (a neo‐epitope pro‐peptide of type III collagen formation) levels across childhood/adolescence and associations with advanced fibrosis in pediatric NAFLD. This cross‐sectional study included 88 children and adolescents with biopsy‐proven NAFLD (mean age: 13.9 ± 2.9 years, 71% male) and 65 healthy participants (11.8 ± 4.5 years, 38% male). PRO‐C3, and the bone remodeling biomarkers C‐terminal telopeptide of type I collagen (CTX‐I; bone resorption) and osteocalcin (N‐MID; bone formation), were measured in serum by enzyme‐linked immunosorbent assay. Fibrosis was assessed by liver biopsy in participants with NAFLD, who were categorized as having advanced (Ishak score ≥ 3) or none/mild fibrosis (Ishak score ≤ 2). Overall, PRO‐C3 was similar in participant...","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_name":"Hepatology Communications"},"translated_abstract":"Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease in children and may lead to cirrhosis requiring liver transplant. Thus, prompt diagnosis of advanced fibrosis is essential. Our objectives were to examine PRO‐C3 (a neo‐epitope pro‐peptide of type III collagen formation) levels across childhood/adolescence and associations with advanced fibrosis in pediatric NAFLD. This cross‐sectional study included 88 children and adolescents with biopsy‐proven NAFLD (mean age: 13.9 ± 2.9 years, 71% male) and 65 healthy participants (11.8 ± 4.5 years, 38% male). PRO‐C3, and the bone remodeling biomarkers C‐terminal telopeptide of type I collagen (CTX‐I; bone resorption) and osteocalcin (N‐MID; bone formation), were measured in serum by enzyme‐linked immunosorbent assay. Fibrosis was assessed by liver biopsy in participants with NAFLD, who were categorized as having advanced (Ishak score ≥ 3) or none/mild fibrosis (Ishak score ≤ 2). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114997743"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114997743/Collagen_Type_III_and_VI_Remodeling_Biomarkers_Are_Associated_with_Kidney_Fibrosis_in_Lupus_Nephritis"><img alt="Research paper thumbnail of Collagen Type III and VI Remodeling Biomarkers Are Associated with Kidney Fibrosis in Lupus Nephritis" class="work-thumbnail" src="https://attachments.academia-assets.com/111535313/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114997743/Collagen_Type_III_and_VI_Remodeling_Biomarkers_Are_Associated_with_Kidney_Fibrosis_in_Lupus_Nephritis">Collagen Type III and VI Remodeling Biomarkers Are Associated with Kidney Fibrosis in Lupus Nephritis</a></div><div class="wp-workCard_item"><span>Kidney360</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Key Points Prognostic biomarkers that identify patients with SLE at risk of developing lupus neph...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Key Points Prognostic biomarkers that identify patients with SLE at risk of developing lupus nephritis and progressing to kidney failure are needed.Tubulointerstitial fibrosis is an important pathologic feature of lupus nephritis and is associated with kidney disease progression.Circulatory and urinary markers of collagen type III and type VI remodeling noninvasively reflect levels of kidney fibrosis in patients with lupus nephritis. Background Lupus nephritis (LN) occurs in &lt;40% of patients with SLE. Reliable biomarkers of kidney damage are needed to identify patients with SLE at risk of developing LN to improve screening, treat the disease earlier, and halt progression to kidney failure. Novel biomarkers of extracellular matrix remodeling were evaluated as markers of kidney fibrosis and disease activity in patients with LN. Methods Biomarkers of the interstitial collagen type III (PRO-C3) and type VI (PRO-C6) formation and of collagen type III (C3M) degradation were evaluated i...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b7754beef778d98ea38ab96628c8214d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111535313,"asset_id":114997743,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111535313/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114997743"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114997743"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114997743; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114997743]").text(description); $(".js-view-count[data-work-id=114997743]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114997743; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114997743']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114997743, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b7754beef778d98ea38ab96628c8214d" } } $('.js-work-strip[data-work-id=114997743]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114997743,"title":"Collagen Type III and VI Remodeling Biomarkers Are Associated with Kidney Fibrosis in Lupus Nephritis","translated_title":"","metadata":{"abstract":"Key Points Prognostic biomarkers that identify patients with SLE at risk of developing lupus nephritis and progressing to kidney failure are needed.Tubulointerstitial fibrosis is an important pathologic feature of lupus nephritis and is associated with kidney disease progression.Circulatory and urinary markers of collagen type III and type VI remodeling noninvasively reflect levels of kidney fibrosis in patients with lupus nephritis. Background Lupus nephritis (LN) occurs in \u0026lt;40% of patients with SLE. Reliable biomarkers of kidney damage are needed to identify patients with SLE at risk of developing LN to improve screening, treat the disease earlier, and halt progression to kidney failure. Novel biomarkers of extracellular matrix remodeling were evaluated as markers of kidney fibrosis and disease activity in patients with LN. Methods Biomarkers of the interstitial collagen type III (PRO-C3) and type VI (PRO-C6) formation and of collagen type III (C3M) degradation were evaluated i...","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Kidney360"},"translated_abstract":"Key Points Prognostic biomarkers that identify patients with SLE at risk of developing lupus nephritis and progressing to kidney failure are needed.Tubulointerstitial fibrosis is an important pathologic feature of lupus nephritis and is associated with kidney disease progression.Circulatory and urinary markers of collagen type III and type VI remodeling noninvasively reflect levels of kidney fibrosis in patients with lupus nephritis. Background Lupus nephritis (LN) occurs in \u0026lt;40% of patients with SLE. Reliable biomarkers of kidney damage are needed to identify patients with SLE at risk of developing LN to improve screening, treat the disease earlier, and halt progression to kidney failure. Novel biomarkers of extracellular matrix remodeling were evaluated as markers of kidney fibrosis and disease activity in patients with LN. Methods Biomarkers of the interstitial collagen type III (PRO-C3) and type VI (PRO-C6) formation and of collagen type III (C3M) degradation were evaluated i...","internal_url":"https://www.academia.edu/114997743/Collagen_Type_III_and_VI_Remodeling_Biomarkers_Are_Associated_with_Kidney_Fibrosis_in_Lupus_Nephritis","translated_internal_url":"","created_at":"2024-02-16T11:28:20.540-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":111535313,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111535313/thumbnails/1.jpg","file_name":"KID.0001132021.full.pdf","download_url":"https://www.academia.edu/attachments/111535313/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Collagen_Type_III_and_VI_Remodeling_Biom.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111535313/KID.0001132021.full-libre.pdf?1708113420=\u0026response-content-disposition=attachment%3B+filename%3DCollagen_Type_III_and_VI_Remodeling_Biom.pdf\u0026Expires=1733187491\u0026Signature=Yye84wHs9SZl7WW-HvanGzC5VJBB8R7BHCWl2tT9jyNSvcY-CpInrX2LnV~JL-ypdEDC2OFt9bnOBaqbtQPppQoMtMjHlmLLU-3cJ8jF1BBlDKJ9sGFEPKrZML0fEbStAYxiCgyQ7~xyK5igM7pv~m2lPN~f6Ji9j7wYUL9lkTse1ro8jk3vTRpuhhgTGM3xZz~7-mI-HkfiHugVx0TwyugDim8aFZITnAArcwgspAVcoos7AlGkQh3uSSw8MzmRJKGy~iD6B~bl8Jlc5DMG3JR~PMQqCExeSduUIBuicjqkZzG90is6dm-xSd3Kd~-lvP5sw1a8Da~v9T23d-8sKQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Collagen_Type_III_and_VI_Remodeling_Biomarkers_Are_Associated_with_Kidney_Fibrosis_in_Lupus_Nephritis","translated_slug":"","page_count":25,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":111535313,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111535313/thumbnails/1.jpg","file_name":"KID.0001132021.full.pdf","download_url":"https://www.academia.edu/attachments/111535313/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Collagen_Type_III_and_VI_Remodeling_Biom.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111535313/KID.0001132021.full-libre.pdf?1708113420=\u0026response-content-disposition=attachment%3B+filename%3DCollagen_Type_III_and_VI_Remodeling_Biom.pdf\u0026Expires=1733187491\u0026Signature=Yye84wHs9SZl7WW-HvanGzC5VJBB8R7BHCWl2tT9jyNSvcY-CpInrX2LnV~JL-ypdEDC2OFt9bnOBaqbtQPppQoMtMjHlmLLU-3cJ8jF1BBlDKJ9sGFEPKrZML0fEbStAYxiCgyQ7~xyK5igM7pv~m2lPN~f6Ji9j7wYUL9lkTse1ro8jk3vTRpuhhgTGM3xZz~7-mI-HkfiHugVx0TwyugDim8aFZITnAArcwgspAVcoos7AlGkQh3uSSw8MzmRJKGy~iD6B~bl8Jlc5DMG3JR~PMQqCExeSduUIBuicjqkZzG90is6dm-xSd3Kd~-lvP5sw1a8Da~v9T23d-8sKQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":165,"name":"Pathology","url":"https://www.academia.edu/Documents/in/Pathology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":440320,"name":"Lupus Nephritis","url":"https://www.academia.edu/Documents/in/Lupus_Nephritis"}],"urls":[{"id":39523520,"url":"https://journals.lww.com/10.34067/KID.0001132021"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114997740"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114997740/Segmentation_of_Overlapped_Steatosis_in_Whole_Slide_Liver_Histopathology_Microscopy_Images"><img alt="Research paper thumbnail of Segmentation of Overlapped Steatosis in Whole-Slide Liver Histopathology Microscopy Images" class="work-thumbnail" src="https://attachments.academia-assets.com/111535304/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114997740/Segmentation_of_Overlapped_Steatosis_in_Whole_Slide_Liver_Histopathology_Microscopy_Images">Segmentation of Overlapped Steatosis in Whole-Slide Liver Histopathology Microscopy Images</a></div><div class="wp-workCard_item"><span>2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)</span><span>, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e623d08cd07d77e2d7851ee6d6d77328" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111535304,"asset_id":114997740,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111535304/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114997740"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114997740"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114997740; 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However, such pathology measurement is manually made in most clinical practices, subject to severe reader variability due to large sampling bias and poor reproducibility. Although some computerized automated methods are developed to quantify the steatosis regions, they present limited analysis capacity for high resolution whole-slide microscopy images and accurate overlapped steatosis division. In this paper, we propose a method that extracts an individual whole tissue piece at high resolution with minimum background area by estimating tissue bounding box and rotation angle. This is followed by the segmentation and segregation of steatosis regions with high curvature point detection and an ellipse fitting quality assessment method. We validate our method with isolated and overlapped steatosis regions in liver tissue images of 11 patients. 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Effect of genetic deletion of MLCK on unmanipulated mice. No statistically significant differences were seen between WT and MLCK-/mice in gut epithelial apoptosis by (A) H\u0026E (p = 0.10) or (B) active caspase 3 (p = 0.18), (C) crypt proliferation (p = 0.19), (D) villus length (p = 0.52), (E) lung MPO (p = 0.20) or (F) BAL MPO (p = 0.22). 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However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ventricular function. The clinical deterioration in patients who have undergone Fontan palliation requires a broader view of circulatory dysfunction, one that takes into account the complex interaction of regulatory systems affecting hepatic, renal, and pulmonary blood flow, in addition to cardiac function. This review focuses primarily on the pathophysiology of multiple organ involvement in this circulatory dysfunction, with particular focus on the consequences of hepatic dysfunction and portal hypertension. The authors discuss hepatic perfusion, both in health and disease, and review the current understanding of liver histopathology and liver disease in adult Fontan patients and similar clinicopathologic states. They compare and contrast features of postsinusoidal portal hypertension with more typical adult cirrhotic disease. 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href="https://www.academia.edu/81898893/Emerging_role_of_B_cells_in_chronic_allograft_dysfunction"><img alt="Research paper thumbnail of Emerging role of B cells in chronic allograft dysfunction" class="work-thumbnail" src="https://attachments.academia-assets.com/87781741/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898893/Emerging_role_of_B_cells_in_chronic_allograft_dysfunction">Emerging role of B cells in chronic allograft dysfunction</a></div><div class="wp-workCard_item"><span>Kidney International</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0f2cb879f6707504f0f71a12072fb315" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898842/Morphometric_and_Visual_Evaluation_of_Fibrosis_in_Renal_Biopsies"><img alt="Research paper thumbnail of Morphometric and Visual Evaluation of Fibrosis in Renal Biopsies" class="work-thumbnail" src="https://attachments.academia-assets.com/87781646/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898842/Morphometric_and_Visual_Evaluation_of_Fibrosis_in_Renal_Biopsies">Morphometric and Visual Evaluation of Fibrosis in Renal Biopsies</a></div><div class="wp-workCard_item"><span>Journal of the American Society of Nephrology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4c61f77fa98c6a32b6a790862a05a4bb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87781646,"asset_id":81898842,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87781646/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81898842"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81898842"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81898842; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=81898842]").text(description); $(".js-view-count[data-work-id=81898842]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 81898842; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='81898842']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 81898842, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4c61f77fa98c6a32b6a790862a05a4bb" } } $('.js-work-strip[data-work-id=81898842]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":81898842,"title":"Morphometric and Visual Evaluation of Fibrosis in Renal Biopsies","translated_title":"","metadata":{"publisher":"American Society of Nephrology (ASN)","grobid_abstract":"Interstitial fibrosis is an outcome measure of increasing importance in clinical trials of both renal transplantation and native disease, but data on the comparative advantages of fibrosis measurement methods are limited. We compared four morphometric techniques and contrasted these with two visual fibrosis-scoring methods on trichrome-stained slides. Two morphometric methods included whole-slide digital images: collagen III immunohistochemistry and a new technique using trichrome and periodic acid-Schiff subtraction morphometry; the other two methods included Sirius Red with and without polarization on multiple digital fields. We evaluated 10 serial sections from 15 renal biopsies with a range of fibrosis extent and diagnoses on duplicate sections with each method on separate days. Three pathologists performed visual scoring on whole-slide images. Visual and morphometric techniques had good to excellent interassay reproducibility (R 2 ϭ 0.62 to 0.96) and interobserver reproducibility (R 2 ϭ 0.75 to 0.99, all P Ͻ 0.001). Morphometry showed less variation between observers than visual assessment (mean of 1% to 5% versus 11% to 13%). Collagen III, Sirius Red unpolarized, and visual scores had the strongest correlations (R 2 ϭ 0.78 to 0.89), the greatest dynamic range, and the best correlation with estimated GFR (R 2 ϭ 0.38 to 0.50, P Ͻ 0.01 to 0.001). Considering efficiency, reproducibility, and functional correlation, two current techniques stand out as potentially the best for clinical trials: collagen III morphometry and visual assessment of trichrome-stained slides.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of the American Society of Nephrology","grobid_abstract_attachment_id":87781646},"translated_abstract":null,"internal_url":"https://www.academia.edu/81898842/Morphometric_and_Visual_Evaluation_of_Fibrosis_in_Renal_Biopsies","translated_internal_url":"","created_at":"2022-06-20T05:57:54.402-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":87781646,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781646/thumbnails/1.jpg","file_name":"176.full.pdf","download_url":"https://www.academia.edu/attachments/87781646/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Morphometric_and_Visual_Evaluation_of_Fi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781646/176.full-libre.pdf?1655730471=\u0026response-content-disposition=attachment%3B+filename%3DMorphometric_and_Visual_Evaluation_of_Fi.pdf\u0026Expires=1733187491\u0026Signature=gW-kdy-XeQchQXVOWarxkDANqdHQJXcX66tObIqnaqeYZ25UUCkdoTFJP~fYqs-dBSLonPjEDIbOqByh-SpBdQPZ705w0V-v76t3yugHhyUhLbxFG3x5qXvn4tYf~55cZLwFWqHfsF0KGJpB5oF2qleyglbF~WW5Y7nt-QOtIyIrWHrT~sXPbpQ8AHq0xnEaBF1Jj-~dV2LTV1~dt6X~GYF-XuU-7KbdXUG0ygyB281G4aMDnkB-wpaMT6BpCnrj8ajVuXBfiutJ1tYU0WbZnM3W2BqAtVi92eerNfga8pFMFOf6oTFQuK0EOBnIuxZKUv6oqEekCSuCBhr9p3rLuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Morphometric_and_Visual_Evaluation_of_Fibrosis_in_Renal_Biopsies","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":87781646,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781646/thumbnails/1.jpg","file_name":"176.full.pdf","download_url":"https://www.academia.edu/attachments/87781646/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Morphometric_and_Visual_Evaluation_of_Fi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781646/176.full-libre.pdf?1655730471=\u0026response-content-disposition=attachment%3B+filename%3DMorphometric_and_Visual_Evaluation_of_Fi.pdf\u0026Expires=1733187491\u0026Signature=gW-kdy-XeQchQXVOWarxkDANqdHQJXcX66tObIqnaqeYZ25UUCkdoTFJP~fYqs-dBSLonPjEDIbOqByh-SpBdQPZ705w0V-v76t3yugHhyUhLbxFG3x5qXvn4tYf~55cZLwFWqHfsF0KGJpB5oF2qleyglbF~WW5Y7nt-QOtIyIrWHrT~sXPbpQ8AHq0xnEaBF1Jj-~dV2LTV1~dt6X~GYF-XuU-7KbdXUG0ygyB281G4aMDnkB-wpaMT6BpCnrj8ajVuXBfiutJ1tYU0WbZnM3W2BqAtVi92eerNfga8pFMFOf6oTFQuK0EOBnIuxZKUv6oqEekCSuCBhr9p3rLuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool"}],"urls":[{"id":21607919,"url":"https://syndication.highwire.org/content/doi/10.1681/ASN.2009091005"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81898811"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898811/Tubular_Expression_of_KIM_1_Does_not_Predict_Delayed_Function_After_Transplantation"><img alt="Research paper thumbnail of Tubular Expression of KIM-1 Does not Predict Delayed Function After Transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/87781663/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898811/Tubular_Expression_of_KIM_1_Does_not_Predict_Delayed_Function_After_Transplantation">Tubular Expression of KIM-1 Does not Predict Delayed Function After Transplantation</a></div><div class="wp-workCard_item"><span>Journal of the American Society of Nephrology</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5765b30798d58ac0029754ebf8ca181a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87781663,"asset_id":81898811,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87781663/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81898811"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81898811"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81898811; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=81898811]").text(description); $(".js-view-count[data-work-id=81898811]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 81898811; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='81898811']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 81898811, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5765b30798d58ac0029754ebf8ca181a" } } $('.js-work-strip[data-work-id=81898811]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":81898811,"title":"Tubular Expression of KIM-1 Does not Predict Delayed Function After Transplantation","translated_title":"","metadata":{"publisher":"American Society of Nephrology (ASN)","grobid_abstract":"Injured epithelial cells of the proximal tubule upregulate the glycoprotein kidney injury molecule 1 (KIM-1), suggesting its potential as a biomarker of incipient kidney allograft injury. It is unknown whether KIM-1 expression changes in kidney allografts with delayed graft function (DGF), which often follows ischemia-reperfusion injury. Here, we prospectively measured KIM-1 RNA and protein expression in preperfusion biopsies of 30 living-and 85 deceased-donor kidneys and correlated the results with histologic and clinical outcomes after transplantation. We detected KIM-1 expression in 62% of deceased-donor kidneys and only 13% of living-donor kidneys (P Ͻ 0.0001). The level of KIM-1 expression before reperfusion correlated inversely with renal function at the time of procurement and correlated directly with the degree of interstitial fibrosis. Surprising, however, we did not detect a significant correlation between KIM-1 staining intensity and the occurrence of DGF. Our findings are consistent with a role for KIM-1 as an early indicator of tubular injury but do not support tissue KIM-1 measurement before transplantation to identify kidneys at risk for DGF.","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"Journal of the American Society of Nephrology","grobid_abstract_attachment_id":87781663},"translated_abstract":null,"internal_url":"https://www.academia.edu/81898811/Tubular_Expression_of_KIM_1_Does_not_Predict_Delayed_Function_After_Transplantation","translated_internal_url":"","created_at":"2022-06-20T05:57:31.686-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":87781663,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781663/thumbnails/1.jpg","file_name":"536.full.pdf","download_url":"https://www.academia.edu/attachments/87781663/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tubular_Expression_of_KIM_1_Does_not_Pre.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781663/536.full-libre.pdf?1655730467=\u0026response-content-disposition=attachment%3B+filename%3DTubular_Expression_of_KIM_1_Does_not_Pre.pdf\u0026Expires=1733187491\u0026Signature=AHW8mI8H-s-3d-H3svIr8khxErn4ViTHaKS~zrx-U728RwD4WpohIw2opLVZDXhQ0N-bVcIBW-pZmPv0yybOP2tNRAKNdarh3PzjsJryplsNBg1pzxjaS6k1T1-AJkrPENmcmaNy~0elV1vyXPYm7YDMnzftn9vebdghfOE8YaIB8GM~I16ZrO7j0FG~tq8QwxBKrMThn1gRGsLjBiuVPv77D~9wdbeKSqav4Xy0Z17LGvhHAB50yKHQx8MQ490JEdLHXFXMkPpMiK-I-FkOuB3AaB0iX4j-EeCgh4ZCWT0PcGajG61hxsCTh5kb6Gyidna1DzYfrsavOiwRxiTrlQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Tubular_Expression_of_KIM_1_Does_not_Predict_Delayed_Function_After_Transplantation","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":87781663,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781663/thumbnails/1.jpg","file_name":"536.full.pdf","download_url":"https://www.academia.edu/attachments/87781663/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tubular_Expression_of_KIM_1_Does_not_Pre.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781663/536.full-libre.pdf?1655730467=\u0026response-content-disposition=attachment%3B+filename%3DTubular_Expression_of_KIM_1_Does_not_Pre.pdf\u0026Expires=1733187491\u0026Signature=AHW8mI8H-s-3d-H3svIr8khxErn4ViTHaKS~zrx-U728RwD4WpohIw2opLVZDXhQ0N-bVcIBW-pZmPv0yybOP2tNRAKNdarh3PzjsJryplsNBg1pzxjaS6k1T1-AJkrPENmcmaNy~0elV1vyXPYm7YDMnzftn9vebdghfOE8YaIB8GM~I16ZrO7j0FG~tq8QwxBKrMThn1gRGsLjBiuVPv77D~9wdbeKSqav4Xy0Z17LGvhHAB50yKHQx8MQ490JEdLHXFXMkPpMiK-I-FkOuB3AaB0iX4j-EeCgh4ZCWT0PcGajG61hxsCTh5kb6Gyidna1DzYfrsavOiwRxiTrlQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":622,"name":"Nephrology","url":"https://www.academia.edu/Documents/in/Nephrology"},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":247948,"name":"Cadaver","url":"https://www.academia.edu/Documents/in/Cadaver"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":794984,"name":"Reperfusion injury","url":"https://www.academia.edu/Documents/in/Reperfusion_injury"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests"},{"id":1663285,"name":"Delayed graft function","url":"https://www.academia.edu/Documents/in/Delayed_graft_function"}],"urls":[{"id":21607906,"url":"https://syndication.highwire.org/content/doi/10.1681/ASN.2009040390"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81898784"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898784/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation"><img alt="Research paper thumbnail of Clinical Utility of Liver Biopsy in Adults with Fontan Palliation" class="work-thumbnail" src="https://attachments.academia-assets.com/87781598/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898784/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation">Clinical Utility of Liver Biopsy in Adults with Fontan Palliation</a></div><div class="wp-workCard_item"><span>Journal of the American College of Cardiology</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8e61830444d216268eacac7558cab101" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87781598,"asset_id":81898784,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87781598/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81898784"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81898784"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81898784; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8e61830444d216268eacac7558cab101" } } $('.js-work-strip[data-work-id=81898784]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":81898784,"title":"Clinical Utility of Liver Biopsy in Adults with Fontan Palliation","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Background: Liver fibrosis is a common complication after Fontan palliation for single ventricle heart defects, but the clinical utility of liver biopsies is unclear. The purpose of this study was to determine if degree of liver fibrosis on biopsy correlates with clinical findings. methods: A chart review of adults with Fontan palliation and a liver biopsy at Emory's Adult Congenital Heart Center was performed (2001-2011). Core liver biopsies were examined using digitally scanned whole slide images of trichrome-stained sections. Portal and lobular fibrosis were quantitated using a positive pixel count algorithm tuned to detect fibrosis. Logistic regression and bivariate correlations were used to examine the relationship between fibrosis and ventricular dysfunction, IVC diameter, clinical features of portal hypertension (defined as ≥2 of the following: platelets \u003c150K, splenomegaly, varices, ascites), and adverse outcomes (death, transplant, or hepatocellular carcinoma [HCC]). results: Ten adults were identified (40% female, mean age 31±7 years). Mean time since Fontan was 18.6 years (range: 6-29), 7 had atriopulmonary connection of whom 4 underwent revision, 8 had a systemic left ventricle, 1 had ventricular dysfunction, and mean IVC diameter was 2.1 ± .23 cm. On biopsy, mean portal area was 1.4 x 105 ± 8.7 x 104 um2 and portal % fibrosis was 66% ± 16%. Mean lobular area was 5.9 x 105 ± 2.4 x 105 um2 and lobular % fibrosis was 20% ± 19%. Features of portal hypertension were present in 7, and 3 had an adverse outcome (death=1, transplant=1, HCC=1). No relationship was found between fibrosis and ventricular dysfunction (p=.26-.59), features of portal hypertension (p=.39-.98), or clinical outcomes (p=.14-.98). A strong positive correlation was found between mean portal area and time since Fontan (r= .82, p=.003) and a moderate trending correlation between portal % fibrosis and IVC diameter (r= .59, p=.07). conclusion: In adult patients following Fontan palliation, quantitative portal fibrosis by liver biopsy increases with time since surgery but does not correlate with clinical outcomes. Further evaluation in a larger population is needed to confirm these findings.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of the American College of Cardiology","grobid_abstract_attachment_id":87781598},"translated_abstract":null,"internal_url":"https://www.academia.edu/81898784/Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation","translated_internal_url":"","created_at":"2022-06-20T05:57:19.160-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":87781598,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781598/thumbnails/1.jpg","file_name":"S0735-1097_2813_2960430-120220620-1-s1mbqe.pdf","download_url":"https://www.academia.edu/attachments/87781598/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Utility_of_Liver_Biopsy_in_Adul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781598/S0735-1097_2813_2960430-120220620-1-s1mbqe-libre.pdf?1655731083=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Utility_of_Liver_Biopsy_in_Adul.pdf\u0026Expires=1733187491\u0026Signature=frqzdjbr7W7pio1gZD1ZnRARypkjObT5hW2lj7X6Ehxcb4mhhNPkhTqMFy2K28yACog2UyXTp6PgdJoi0la1mfWGzd9m3qgft4lGwDJbzABfPXmhvU3aNMFNY8iwonqBrVFJCAVAuL4FcM-z2s~DNKMcwjv4Wzf0-d8Hhro0tu47VgmxlUYVdqSYtTPxMtSapnyrLF2sVPPq5GbESDpzzghg5Q1uJZPPJuPU0gLCR1R2V3wWXPCfVCE1aDxm9NNEX4s4Ayb-YKeyhrq7UvVAYqGlGnj5OgPvlHZfaFAB-AckJ756VleWRzngqOIqmzLRSexjmYiDkFx82RlVEEte5Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Clinical_Utility_of_Liver_Biopsy_in_Adults_with_Fontan_Palliation","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":87781598,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781598/thumbnails/1.jpg","file_name":"S0735-1097_2813_2960430-120220620-1-s1mbqe.pdf","download_url":"https://www.academia.edu/attachments/87781598/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Utility_of_Liver_Biopsy_in_Adul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781598/S0735-1097_2813_2960430-120220620-1-s1mbqe-libre.pdf?1655731083=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Utility_of_Liver_Biopsy_in_Adul.pdf\u0026Expires=1733187491\u0026Signature=frqzdjbr7W7pio1gZD1ZnRARypkjObT5hW2lj7X6Ehxcb4mhhNPkhTqMFy2K28yACog2UyXTp6PgdJoi0la1mfWGzd9m3qgft4lGwDJbzABfPXmhvU3aNMFNY8iwonqBrVFJCAVAuL4FcM-z2s~DNKMcwjv4Wzf0-d8Hhro0tu47VgmxlUYVdqSYtTPxMtSapnyrLF2sVPPq5GbESDpzzghg5Q1uJZPPJuPU0gLCR1R2V3wWXPCfVCE1aDxm9NNEX4s4Ayb-YKeyhrq7UvVAYqGlGnj5OgPvlHZfaFAB-AckJ756VleWRzngqOIqmzLRSexjmYiDkFx82RlVEEte5Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81898762"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898762/Eosinophilic_granulomatous_gastrointestinal_and_hepatic_abscesses_attributable_to_basidiobolomycosis_and_fasciolias_a_simultaneous_emergence_in_Iraqi_Kurdistan"><img alt="Research paper thumbnail of Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan" class="work-thumbnail" src="https://attachments.academia-assets.com/87781554/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898762/Eosinophilic_granulomatous_gastrointestinal_and_hepatic_abscesses_attributable_to_basidiobolomycosis_and_fasciolias_a_simultaneous_emergence_in_Iraqi_Kurdistan">Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan</a></div><div class="wp-workCard_item"><span>BMC Infectious Diseases</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Deep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutan...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Deep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutaneous abscesses, are rare. Most reports are from the Far-East and India where the most commonly attributed cause is Toxocara. Sulaimaniyah in Northeastern Iraq has experienced an outbreak of eosinophilic granulomatous liver and gastrointestinal (GI) abscesses beginning in 2009. The purpose of this study was to determine the etiology and guide treatment. Methods The study was an ongoing investigation of patients having a histopathologic diagnosis of eosinophilic granulomatous abdominal abscesses in Sulaimaniyah hospitals from May 2009 to August 2012. Tissues were examined for organisms, and Enzyme Linked Immunoabsorbent Assays (ELISA) were performed for serum antibodies to Fasciola hepatica, Toxocara, and Echinococcus granulosus. Results Fourteen patients had granulomatous inflammation surrounding a central necrotizing eosinophilic exudate identified in surgical pathology specimens from ab...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="807bb4a015e2c347f2549579fa7512d8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87781554,"asset_id":81898762,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87781554/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81898762"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81898762"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81898762; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=81898762]").text(description); $(".js-view-count[data-work-id=81898762]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 81898762; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='81898762']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 81898762, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "807bb4a015e2c347f2549579fa7512d8" } } $('.js-work-strip[data-work-id=81898762]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":81898762,"title":"Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan","translated_title":"","metadata":{"abstract":"Background Deep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutaneous abscesses, are rare. Most reports are from the Far-East and India where the most commonly attributed cause is Toxocara. Sulaimaniyah in Northeastern Iraq has experienced an outbreak of eosinophilic granulomatous liver and gastrointestinal (GI) abscesses beginning in 2009. The purpose of this study was to determine the etiology and guide treatment. Methods The study was an ongoing investigation of patients having a histopathologic diagnosis of eosinophilic granulomatous abdominal abscesses in Sulaimaniyah hospitals from May 2009 to August 2012. Tissues were examined for organisms, and Enzyme Linked Immunoabsorbent Assays (ELISA) were performed for serum antibodies to Fasciola hepatica, Toxocara, and Echinococcus granulosus. Results Fourteen patients had granulomatous inflammation surrounding a central necrotizing eosinophilic exudate identified in surgical pathology specimens from ab...","publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"BMC Infectious Diseases"},"translated_abstract":"Background Deep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutaneous abscesses, are rare. Most reports are from the Far-East and India where the most commonly attributed cause is Toxocara. Sulaimaniyah in Northeastern Iraq has experienced an outbreak of eosinophilic granulomatous liver and gastrointestinal (GI) abscesses beginning in 2009. The purpose of this study was to determine the etiology and guide treatment. Methods The study was an ongoing investigation of patients having a histopathologic diagnosis of eosinophilic granulomatous abdominal abscesses in Sulaimaniyah hospitals from May 2009 to August 2012. Tissues were examined for organisms, and Enzyme Linked Immunoabsorbent Assays (ELISA) were performed for serum antibodies to Fasciola hepatica, Toxocara, and Echinococcus granulosus. Results Fourteen patients had granulomatous inflammation surrounding a central necrotizing eosinophilic exudate identified in surgical pathology specimens from ab...","internal_url":"https://www.academia.edu/81898762/Eosinophilic_granulomatous_gastrointestinal_and_hepatic_abscesses_attributable_to_basidiobolomycosis_and_fasciolias_a_simultaneous_emergence_in_Iraqi_Kurdistan","translated_internal_url":"","created_at":"2022-06-20T05:57:00.352-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":87781554,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781554/thumbnails/1.jpg","file_name":"1471-2334-13-91.pdf","download_url":"https://www.academia.edu/attachments/87781554/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Eosinophilic_granulomatous_gastrointesti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781554/1471-2334-13-91-libre.pdf?1655731092=\u0026response-content-disposition=attachment%3B+filename%3DEosinophilic_granulomatous_gastrointesti.pdf\u0026Expires=1733187491\u0026Signature=B1Kti4j0AKrHSGPLdrWJsjvzownqAsl3rieMwH7uCdv8fqGi0M72LkdjHNGfDvFlB5YHsD0sOxfp4wBCnSG0Hfkf~gQCyaMDdqWIPNe1DBTPElfDYsQesu5MY86fi632nt3HgxHP2HXC-xN-hqnCZN6oAAf21BS0hbxV6DQ49sYwSN0kXzAxqKI4n3rwHzfgjCkM6pW7F48zrETpWsfMYWUhZNqSxJX1GZI5jEsZofZr1MW2dWP0BEcPScaJRLG1mvdJe6ExsIjHIgrWYNyxKZGktOoJmCdGDwYfxQJZ8tbcJRSf8fOT7~BiKW7ZAsnRrzNrGooNJuoZfCxT-KF9Sw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Eosinophilic_granulomatous_gastrointestinal_and_hepatic_abscesses_attributable_to_basidiobolomycosis_and_fasciolias_a_simultaneous_emergence_in_Iraqi_Kurdistan","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":87781554,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781554/thumbnails/1.jpg","file_name":"1471-2334-13-91.pdf","download_url":"https://www.academia.edu/attachments/87781554/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Eosinophilic_granulomatous_gastrointesti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781554/1471-2334-13-91-libre.pdf?1655731092=\u0026response-content-disposition=attachment%3B+filename%3DEosinophilic_granulomatous_gastrointesti.pdf\u0026Expires=1733187491\u0026Signature=B1Kti4j0AKrHSGPLdrWJsjvzownqAsl3rieMwH7uCdv8fqGi0M72LkdjHNGfDvFlB5YHsD0sOxfp4wBCnSG0Hfkf~gQCyaMDdqWIPNe1DBTPElfDYsQesu5MY86fi632nt3HgxHP2HXC-xN-hqnCZN6oAAf21BS0hbxV6DQ49sYwSN0kXzAxqKI4n3rwHzfgjCkM6pW7F48zrETpWsfMYWUhZNqSxJX1GZI5jEsZofZr1MW2dWP0BEcPScaJRLG1mvdJe6ExsIjHIgrWYNyxKZGktOoJmCdGDwYfxQJZ8tbcJRSf8fOT7~BiKW7ZAsnRrzNrGooNJuoZfCxT-KF9Sw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":11589,"name":"Iraq","url":"https://www.academia.edu/Documents/in/Iraq"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle"},{"id":988280,"name":"Abscess","url":"https://www.academia.edu/Documents/in/Abscess"},{"id":2430299,"name":"Gastrointestinal Diseases","url":"https://www.academia.edu/Documents/in/Gastrointestinal_Diseases"},{"id":2756122,"name":"Fascioliasis","url":"https://www.academia.edu/Documents/in/Fascioliasis"},{"id":3238443,"name":"eosinophilic granuloma","url":"https://www.academia.edu/Documents/in/eosinophilic_granuloma"}],"urls":[{"id":21607885,"url":"http://link.springer.com/content/pdf/10.1186/1471-2334-13-91.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81898754"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898754/Acute_Renal_Endothelial_Injury_During_Marrow_Recovery_in_a_Cohort_of_Combined_Kidney_and_Bone_Marrow_Allografts"><img alt="Research paper thumbnail of Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts" class="work-thumbnail" src="https://attachments.academia-assets.com/87781581/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898754/Acute_Renal_Endothelial_Injury_During_Marrow_Recovery_in_a_Cohort_of_Combined_Kidney_and_Bone_Marrow_Allografts">Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts</a></div><div class="wp-workCard_item"><span>American Journal of Transplantation</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f42df84221a0c23f65ba24edf621d23" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87781581,"asset_id":81898754,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87781581/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81898754"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81898754"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81898754; 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Here we report the renal pathology in 10 recipients of combined bone marrow and kidney allografts. Nine developed graft dysfunction on day 10-16 and renal biopsies showed marked acute tubular injury, with interstitial edema, hemorrhage and capillary congestion, with little or no interstitial infiltrate (≤10%) and marked glomerular and peritubular capillary (PTC) endothelial injury and loss by electron microscopy. Two had transient arterial endothelial inflammation; and 2 had C4d deposition. The cells in capillaries were primarily CD68 + MPO + mononuclear cells and CD3 + CD8 + T cells, the latter with a high proliferative index (Ki67 +). B cells (CD20 +) and CD4 + T cells were not detectable, and NK cells were rare. XY FISH showed that CD45 + cells in PTCs were of recipient origin. Optimal treatment remains to be defined; two recovered without additional therapy, six were treated with anti-rejection regimens. Except for one patient, who later developed thrombotic microangiopathy and one with acute humoral rejection, all fully recovered within 2-4 weeks. Graft endothelium is the primary target of this process, attributable to as yet obscure mechanisms, arising during leukocyte recovery.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"American Journal of Transplantation","grobid_abstract_attachment_id":87781581},"translated_abstract":null,"internal_url":"https://www.academia.edu/81898754/Acute_Renal_Endothelial_Injury_During_Marrow_Recovery_in_a_Cohort_of_Combined_Kidney_and_Bone_Marrow_Allografts","translated_internal_url":"","created_at":"2022-06-20T05:56:48.499-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44516105,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":87781581,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781581/thumbnails/1.jpg","file_name":"nihms294038.pdf","download_url":"https://www.academia.edu/attachments/87781581/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acute_Renal_Endothelial_Injury_During_Ma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781581/nihms294038-libre.pdf?1655731088=\u0026response-content-disposition=attachment%3B+filename%3DAcute_Renal_Endothelial_Injury_During_Ma.pdf\u0026Expires=1733187491\u0026Signature=T26GEiDcJZYiOabSq-yQgisPQ~T921VNz12tfz8hiYHzBzsdNoDYW7msczr~LTmSrym8OLCR4Vo2DqJudMINAaA97lguOv~2kDAsmOCxs4EQ4gzWdiI4iG5ygIaP9TQbtOSP0blNzCOW9QGsDTPUofCt-H6kotUg26tR3fCzDH3iyW3goxxXcSaqbN4TDdWGzwu31h-WsV8GhYhrPAlN~8qxYTe-y-wAFKojYMN8IfeVbDGjQYr1xOhEDRxM6ACWII-tUTpuDrQb2LpT3dvsxl3~2~FQIBpF~IPr~WvsTFw~IVj8TZA83fB112fIHvII-lCw8ax35G~NJ6InWjqq7w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Acute_Renal_Endothelial_Injury_During_Marrow_Recovery_in_a_Cohort_of_Combined_Kidney_and_Bone_Marrow_Allografts","translated_slug":"","page_count":26,"language":"en","content_type":"Work","owner":{"id":44516105,"first_name":"Alton","middle_initials":null,"last_name":"Farris","page_name":"AltonFarris","domain_name":"independent","created_at":"2016-03-05T12:30:06.574-08:00","display_name":"Alton Farris","url":"https://independent.academia.edu/AltonFarris"},"attachments":[{"id":87781581,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87781581/thumbnails/1.jpg","file_name":"nihms294038.pdf","download_url":"https://www.academia.edu/attachments/87781581/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acute_Renal_Endothelial_Injury_During_Ma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87781581/nihms294038-libre.pdf?1655731088=\u0026response-content-disposition=attachment%3B+filename%3DAcute_Renal_Endothelial_Injury_During_Ma.pdf\u0026Expires=1733187491\u0026Signature=T26GEiDcJZYiOabSq-yQgisPQ~T921VNz12tfz8hiYHzBzsdNoDYW7msczr~LTmSrym8OLCR4Vo2DqJudMINAaA97lguOv~2kDAsmOCxs4EQ4gzWdiI4iG5ygIaP9TQbtOSP0blNzCOW9QGsDTPUofCt-H6kotUg26tR3fCzDH3iyW3goxxXcSaqbN4TDdWGzwu31h-WsV8GhYhrPAlN~8qxYTe-y-wAFKojYMN8IfeVbDGjQYr1xOhEDRxM6ACWII-tUTpuDrQb2LpT3dvsxl3~2~FQIBpF~IPr~WvsTFw~IVj8TZA83fB112fIHvII-lCw8ax35G~NJ6InWjqq7w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":9000,"name":"Acute kidney injury","url":"https://www.academia.edu/Documents/in/Acute_kidney_injury"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65882,"name":"Fluorescence in situ hybridization","url":"https://www.academia.edu/Documents/in/Fluorescence_in_situ_hybridization"},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American"},{"id":159239,"name":"Bone marrow","url":"https://www.academia.edu/Documents/in/Bone_marrow"},{"id":354937,"name":"Bone Marrow Transplantation","url":"https://www.academia.edu/Documents/in/Bone_Marrow_Transplantation"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":1281484,"name":"Capillary Leak Syndrome","url":"https://www.academia.edu/Documents/in/Capillary_Leak_Syndrome"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3834134,"name":"leukocyte Count","url":"https://www.academia.edu/Documents/in/leukocyte_Count"}],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81898741"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81898741/Development_of_focal_segmental_glomerulosclerosis_in_the_renal_allograft_of_a_patient_with_lupus"><img alt="Research paper thumbnail of Development of focal segmental glomerulosclerosis in the renal allograft of a patient with lupus" class="work-thumbnail" src="https://attachments.academia-assets.com/87781577/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81898741/Development_of_focal_segmental_glomerulosclerosis_in_the_renal_allograft_of_a_patient_with_lupus">Development of focal segmental glomerulosclerosis in the renal allograft of a patient with lupus</a></div><div class="wp-workCard_item"><span>American Journal of Kidney Diseases</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f083d5b29a08a94a24bc63951bd4b067" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87781577,"asset_id":81898741,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87781577/download_file?st=MTczMzE5MTQyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81898741"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81898741"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81898741; 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This study aimed to develop patient-reported outcome questionnaires to measure patient experiences related to FSGS. Study Design: Qualitative patient interviews to identify important symptoms and concepts (concept elicitation) formed the basis for the development of 2 questionnaires, one on symptoms and one on their impact. Additional qualitative interviews were implemented to evaluate/refine the questionnaires (cognitive debriefing). Transcripts of concept elicitation and cognitive debriefing interviews, conducted by telephone, were analyzed for concepts of interest using qualitative text analysis. Setting \u0026 Participants: Patients with FSGS (aged 18-65 years with estimated glomerular filtration rates $ 40 mL/min/1.73 m 2) whose disease remained inadequately controlled after 2 or fewer courses of treatment. Methodology: Qualitative concept elicitation and cognitive debriefing interviews. Analytical Approach: Interview transcripts were analyzed using qualitative software, MAXQDA. Results: 30 patients completed concept elicitation interviews; 9 patients completed cognitive debriefing interviews. Frequently mentioned symptoms included swelling from the waist down/legs/knees/feet/ankles (67%), fatigue (57%), stomach/abdomen swelling (43%), body pain/pressure (30%), and shortness of breath (20%), as well as impacts on physical (52%), emotional (68%), and social functioning (89%). Based on analyses of interview transcripts and clinical input, 2 questionnaires, one on symptoms and one on the impact of the symptom, were drafted. The 23-item FSGS Symptom Diary (assessing the frequency and severity of FSGS symptoms during the past 24 hours) and the FSGS Symptom Impact Questionnaire (17 items assessing interference with activities and emotions during the past 7 days) were iteratively revised based on cognitive debriefing interviews. Limitations: The study was restricted to English-speaking adults located in the United States, and the concept elicitation interview group had a low number of African Americans. Conclusions: The FSGS Symptom Diary and FSGS Symptom Impact Questionnaire are new FSGSspecific patient-reported outcomes measures designed to support a comprehensive assessment of symptoms and symptom impact in adults with FSGS. 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