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window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":81898811,"created_at":"2022-06-20T05:57:31.686-07:00","from_world_paper_id":208880404,"updated_at":"2024-11-22T20:54:42.032-08:00","_data":{"publisher":"American Society of Nephrology (ASN)","grobid_abstract":"Injured epithelial cells of the proximal tubule upregulate the glycoprotein kidney injury molecule 1 (KIM-1), suggesting its potential as a biomarker of incipient kidney allograft injury. It is unknown whether KIM-1 expression changes in kidney allografts with delayed graft function (DGF), which often follows ischemia-reperfusion injury. Here, we prospectively measured KIM-1 RNA and protein expression in preperfusion biopsies of 30 living-and 85 deceased-donor kidneys and correlated the results with histologic and clinical outcomes after transplantation. We detected KIM-1 expression in 62% of deceased-donor kidneys and only 13% of living-donor kidneys (P Ͻ 0.0001). The level of KIM-1 expression before reperfusion correlated inversely with renal function at the time of procurement and correlated directly with the degree of interstitial fibrosis. Surprising, however, we did not detect a significant correlation between KIM-1 staining intensity and the occurrence of DGF. Our findings are consistent with a role for KIM-1 as an early indicator of tubular injury but do not support tissue KIM-1 measurement before transplantation to identify kidneys at risk for DGF.","publication_date":"2009,,","publication_name":"Journal of the American Society of Nephrology","grobid_abstract_attachment_id":"87781663"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Tubular Expression of KIM-1 Does not Predict Delayed Function After Transplantation","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [44516105]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":87781663,"attachmentType":"pdf"}"><img alt="First page of “Tubular Expression of KIM-1 Does not Predict Delayed Function After Transplantation”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/87781663/mini_magick20220620-12210-nzz9vb.png?1655730055" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Tubular Expression of KIM-1 Does not Predict Delayed Function After Transplantation</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="44516105" href="https://independent.academia.edu/AltonFarris"><img alt="Profile image of Alton Farris" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Alton Farris</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2009, Journal of the American Society of Nephrology</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">7 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 81898811; 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In this study we evaluated the molecular and protein expressions of KIM-1 in dysfunctional allografts and also mRNA KIM-1 expression in urine as potential biomarkers of graft fibrosis. Protein and mRNA levels in renal tissue and urinary sediment cells of 69 kidney transplant recipients that undertook for-cause graft biopsies were evaluated by immunohistochemistry and real-time polymerase chain reaction. The histopathology was classified according to the 2007 Banff schema. KIM-1 protein expression was increased in biopsies with interstitial fibrosis and tubular atrophy (IF/TA) compared with biopsies showing acute calcineurin inhibitor nephrotoxicity (CIN) (P &lt;0.05). Kidney tissue KIM-1 mRNA signaling (in) was increased in biopsies with IF/TA compared with all other groups (P &lt;0.05). In the urine cells KIM-1 mRNA was also increase...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Kidney injury molecule-1 expression in human kidney transplants with interstitial fibrosis and tubular atrophy","attachmentId":44844949,"attachmentType":"pdf","work_url":"https://www.academia.edu/13879388/Kidney_injury_molecule_1_expression_in_human_kidney_transplants_with_interstitial_fibrosis_and_tubular_atrophy","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13879388/Kidney_injury_molecule_1_expression_in_human_kidney_transplants_with_interstitial_fibrosis_and_tubular_atrophy"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="87227337" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/87227337/Noninvasive_Analyses_of_Kidney_Injury_Molecule_1_Messenger_RNA_in_Kidney_Transplant_Recipients_With_Graft_Dysfunction">Noninvasive Analyses of Kidney Injury Molecule-1 Messenger RNA in Kidney Transplant Recipients With Graft Dysfunction</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="206326949" href="https://independent.academia.edu/AlineNogare">Aline Nogare</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Transplantation Proceedings, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Noninvasive Analyses of Kidney Injury Molecule-1 Messenger RNA in Kidney Transplant Recipients With Graft Dysfunction","attachmentId":91497181,"attachmentType":"pdf","work_url":"https://www.academia.edu/87227337/Noninvasive_Analyses_of_Kidney_Injury_Molecule_1_Messenger_RNA_in_Kidney_Transplant_Recipients_With_Graft_Dysfunction","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/87227337/Noninvasive_Analyses_of_Kidney_Injury_Molecule_1_Messenger_RNA_in_Kidney_Transplant_Recipients_With_Graft_Dysfunction"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="60854605" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/60854605/Tissue_Kidney_Injury_Molecule_1_Expression_in_the_Prediction_of_Renal_Function_for_Several_Years_after_Kidney_Biopsy">Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34538706" href="https://independent.academia.edu/SanjaOgrizovic">Sanja Ogrizovic</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Disease Markers, 2013</p><p class="ds-related-work--abstract ds2-5-body-sm">Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy.Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later.Results. Significantly positive correlations between tissue KIM-1 expression and age (r=0.313), TIN inflammation (r=0.456), fibrosis (r=0.317), and proteinuria at 6 months (r=0.394) as well as negative correlations with GFR0 (r=−0.572), GFR6 (r=−0.442), GFR24 (r=−0.398), and GFR36 (r=−0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney f...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy","attachmentId":74117887,"attachmentType":"pdf","work_url":"https://www.academia.edu/60854605/Tissue_Kidney_Injury_Molecule_1_Expression_in_the_Prediction_of_Renal_Function_for_Several_Years_after_Kidney_Biopsy","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/60854605/Tissue_Kidney_Injury_Molecule_1_Expression_in_the_Prediction_of_Renal_Function_for_Several_Years_after_Kidney_Biopsy"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="63606198" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63606198/Kidney_injury_molecule_1_KIM_1_a_urinary_biomarker_and_much_more">Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="95383152" href="https://independent.academia.edu/BonventreJoseph">Joseph Bonventre</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Nephrology Dialysis Transplantation, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more","attachmentId":75979963,"attachmentType":"pdf","work_url":"https://www.academia.edu/63606198/Kidney_injury_molecule_1_KIM_1_a_urinary_biomarker_and_much_more","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/63606198/Kidney_injury_molecule_1_KIM_1_a_urinary_biomarker_and_much_more"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="90120018" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90120018/Kidney_Injury_Molecule_1_KIM_1_A_novel_biomarker_for_human_renal_proximal_tubule_injury">Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="95383152" href="https://independent.academia.edu/BonventreJoseph">Joseph Bonventre</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Kidney International, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury","attachmentId":93770395,"attachmentType":"pdf","work_url":"https://www.academia.edu/90120018/Kidney_Injury_Molecule_1_KIM_1_A_novel_biomarker_for_human_renal_proximal_tubule_injury","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/90120018/Kidney_Injury_Molecule_1_KIM_1_A_novel_biomarker_for_human_renal_proximal_tubule_injury"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="109920760" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/109920760/Urinary_KIM_1_Correlates_with_the_Subclinical_Sequelae_of_Tubular_Damage_Persisting_after_the_Apparent_Functional_Recovery_from_Intrinsic_Acute_Kidney_Injury">Urinary KIM-1 Correlates with the Subclinical Sequelae of Tubular Damage Persisting after the Apparent Functional Recovery from Intrinsic Acute Kidney Injury</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="184960491" href="https://independent.academia.edu/ANNETTEGISELAD%C3%9CWEL">ANNETTE GISELA DÜWEL</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biomedicines</p><p class="ds-related-work--abstract ds2-5-body-sm">Acute kidney injury (AKI) poses an increased risk factor for new AKI episodes, progression to chronic kidney disease, and death. A worsened evolution has been linked to an incomplete renal repair beyond the apparent functional recovery based on plasma creatinine (pCr) normalization. However, structural sequelae pass largely unnoticed due to the absence of specific diagnostic tools. The urinary kidney injury molecule 1 (KIM-1) participates in renal tissue damage and repair and is proposed as a biomarker of early and subclinical AKI. Thus, we study in this paper the evolution of KIM-1 urinary excretion alongside renal tissue sequelae after an intrinsic AKI episode induced by cisplatin in Wistar rats. Creatinine clearance, pCr, proteinuria and the fractional excretion of Na+ and glucose were used to monitor renal function. Renal tissue damage was blindly scored in kidney specimens stained with hematoxylin–eosin and periodic acid–Schiff. KIM-1 urinary excretion and renal mRNA expression...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Urinary KIM-1 Correlates with the Subclinical Sequelae of Tubular Damage Persisting after the Apparent Functional Recovery from Intrinsic Acute Kidney Injury","attachmentId":107899251,"attachmentType":"pdf","work_url":"https://www.academia.edu/109920760/Urinary_KIM_1_Correlates_with_the_Subclinical_Sequelae_of_Tubular_Damage_Persisting_after_the_Apparent_Functional_Recovery_from_Intrinsic_Acute_Kidney_Injury","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/109920760/Urinary_KIM_1_Correlates_with_the_Subclinical_Sequelae_of_Tubular_Damage_Persisting_after_the_Apparent_Functional_Recovery_from_Intrinsic_Acute_Kidney_Injury"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="11545101" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/11545101/High_urinary_excretion_of_kidney_injury_molecule_1_is_an_independent_predictor_of_graft_loss_in_renal_transplant_recipients">High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="28188374" href="https://independent.academia.edu/MirjanvanTimmeren">Mirjan van Timmeren</a></div><p class="ds-related-work--metadata ds2-5-body-xs">…, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients","attachmentId":46640545,"attachmentType":"pdf","work_url":"https://www.academia.edu/11545101/High_urinary_excretion_of_kidney_injury_molecule_1_is_an_independent_predictor_of_graft_loss_in_renal_transplant_recipients","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/11545101/High_urinary_excretion_of_kidney_injury_molecule_1_is_an_independent_predictor_of_graft_loss_in_renal_transplant_recipients"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="18676300" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18676300/Molecular_Predictors_of_Delayed_Graft_Function_of_Kidney_Allograft">Molecular Predictors of Delayed Graft Function of Kidney Allograft</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38749717" href="https://independent.academia.edu/EvaHonsova">Eva Honsova</a></div><p class="ds-related-work--metadata 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data-entity-id="95659228" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/95659228/Kidney_Injury_Molecule_1_Protects_against_G%CE%B112_Activation_and_Tissue_Damage_in_Renal_Ischemia_Reperfusion_Injury">Kidney Injury Molecule-1 Protects against Gα12 Activation and Tissue Damage in Renal Ischemia-Reperfusion Injury</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39306037" href="https://independent.academia.edu/AlpSener">Alp Sener</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The American Journal of Pathology, 2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Kidney Injury Molecule-1 Protects against Gα12 Activation and Tissue Damage in 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