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Rivka Ben-Sasson - Academia.edu
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class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">Having MSc degree in Botany and worked in the Diabetes unit at Hdassah Hospital in Jerusalem for 25 years- now retired. Started MA in Jewish Art and got PHd in Art history in 2013. All degrees from Hebrew University in Jerusalem.<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span><a class="ri-more-link js-profile-ri-list-card" data-click-track="profile-user-info-primary-research-interest" data-has-card-for-ri-list="15775411">View All (35)</a></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="15775411" href="https://www.academia.edu/Documents/in/Jewish_Art_History"><div id="js-react-on-rails-context" style="display:none" 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href="https://www.academia.edu/109832704/Morpho_cytochemical_and_biochemical_evidence_for_insulin_absorption_by_the_rat_ileal_epithelium">Morpho-cytochemical and biochemical evidence for insulin absorption by the rat ileal epithelium</a></div><div class="wp-workCard_item"><span>Diabetologia</span><span>, Apr 1, 1990</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fd33af24aa1ec5cbeeb3ae0b6507b469" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":107838044,"asset_id":109832704,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/107838044/download_file?st=MTczMjg0MzI1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span 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_.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fd33af24aa1ec5cbeeb3ae0b6507b469" } } $('.js-work-strip[data-work-id=109832704]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":109832704,"title":"Morpho-cytochemical and biochemical evidence for insulin absorption by the rat ileal epithelium","translated_title":"","metadata":{"publisher":"Springer Science+Business Media","grobid_abstract":"In order to investigate the mechanism through which insulin is absorbed by the intestinal epithelium and transferred to the circulation where it exercises its biological activity of lowering blood glucose levels, a combined biochemical morpho-cytochemical study was undertaken on rat ileal tissue, in vivo. Insulin was introduced into the lumen of the ileum in combination with sodium chelate and aprotinin and allowed to be absorbed for various periods of time. Analysis of blood samples from the inferior vena cava, at different time points has demonstrated an increase in plasma insulin followed by a decrease in blood glucose levels. The ileal tissues were studied at different time points after the introduction of the insulin, by applying the protein A-gold immunocytochemical technique. Insulin antigenic sites were detected with high resolution, at various levels of the enterocytes but were absent from goblet cells. At 2 to 5 min, the labelling was mainly associated with the microvilli and endocytotic vesicles in the apical portion of the epithelial cells. Some gold particles were in contact with the lateral membranes. At 10 min, the labelling was found at the level of the trans-side of the Golgi apparatus and mainly along the base-lateral membranes of the epithelial cells. Labelling was also detected in the interstitial space. The control experiments have demonstrated the specificity of the labelling and confirmed the nature of the insulin molecules detected. Furthermore, the morphological study has confirmed that exposure of the tissue to the insulin-chelate aprotinin solution does not affect the integrity of the epithelium while promoting insulin absorption. Thus, insulin introduced in the lumen of the rat ileum in conjunction with sodium chelate and aprotinin, appears to be rapidly absorbed by the epithelial cells and transferred to the circulation through a transcytotic 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data-work-id="109832703"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/109832703/Biochemical_and_morpho_cytochemical_evidence_for_the_intestinal_absorption_of_insulin_in_control_and_diabetic_rats_Comparison_between_the_effectiveness_of_duodenal_and_colon_mucosa"><img alt="Research paper thumbnail of Biochemical and morpho-cytochemical evidence for the intestinal absorption of insulin in control and diabetic rats. Comparison between the effectiveness of duodenal and colon mucosa" class="work-thumbnail" src="https://attachments.academia-assets.com/107838113/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109832703/Biochemical_and_morpho_cytochemical_evidence_for_the_intestinal_absorption_of_insulin_in_control_and_diabetic_rats_Comparison_between_the_effectiveness_of_duodenal_and_colon_mucosa">Biochemical and morpho-cytochemical evidence for the intestinal absorption of insulin in control and diabetic rats. Comparison between the effectiveness of duodenal and colon mucosa</a></div><div class="wp-workCard_item"><span>Diabetologia</span><span>, Feb 1, 1994</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f91d09a9bc3085399d7aee52949a075d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":107838113,"asset_id":109832703,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/107838113/download_file?st=MTczMjg0MzI1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109832703"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109832703"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109832703; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=109832703]").text(description); $(".js-view-count[data-work-id=109832703]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 109832703; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='109832703']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 109832703, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f91d09a9bc3085399d7aee52949a075d" } } $('.js-work-strip[data-work-id=109832703]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":109832703,"title":"Biochemical and morpho-cytochemical evidence for the intestinal absorption of insulin in control and diabetic rats. 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The integrity of the intestinal wall after insulin administration, evaluated morphologically, was retained. Application of protein A-gold immunocytochemistry has established the pathway for insulin 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data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/109832702/Immunocytochemical_investigation_of_insulin_secretion_by_pancreatic_beta_cells_in_control_and_diabetic_Psammomys_obesus"><img alt="Research paper thumbnail of Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus" class="work-thumbnail" src="https://attachments.academia-assets.com/108848461/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109832702/Immunocytochemical_investigation_of_insulin_secretion_by_pancreatic_beta_cells_in_control_and_diabetic_Psammomys_obesus">Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus</a></div><div class="wp-workCard_item"><span>Journal of Histochemistry &amp; Cytochemistry</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Hyperproinsulinemia is a characteristic feature of non-insulin-dependent diabetes mellitus (NIDDM...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hyperproinsulinemia is a characteristic feature of non-insulin-dependent diabetes mellitus (NIDDM) caused by pancreatic beta-cell dysfunction through a secretion-related alteration or impaired proinsulin processing. We have investigated the insulin processing and secretion in Psammomys obesus fed with low- and high-energy diets, which represent a model for diet-induced NIDDM. With a high-energy diet the animals develop hyperglycemia and hyperinsulinemia, whereas those maintained on a low-energy diet remain normoglycemic. Although a large amount of insulin immunoreactivity was detected in beta-cells of the normoglycemic compared to hyperglycemic animals, in situ hybridization for insulin mRNA demonstrated a particularly high signal in the beta-cells of the hyperglycemic animals. By electron microscopy, the beta-cells of normoglycemic animals displayed large accumulations of secretory granules, whereas those of the hyperglycemic animals contained very few granules and large deposits o...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4067b11fca301502569ffb4067fdb66e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108848461,"asset_id":109832702,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108848461/download_file?st=MTczMjg0MzI1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109832702"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109832702"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109832702; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=109832702]").text(description); $(".js-view-count[data-work-id=109832702]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 109832702; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='109832702']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 109832702, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4067b11fca301502569ffb4067fdb66e" } } $('.js-work-strip[data-work-id=109832702]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":109832702,"title":"Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus","translated_title":"","metadata":{"abstract":"Hyperproinsulinemia is a characteristic feature of non-insulin-dependent diabetes mellitus (NIDDM) caused by pancreatic beta-cell dysfunction through a secretion-related alteration or impaired proinsulin processing. We have investigated the insulin processing and secretion in Psammomys obesus fed with low- and high-energy diets, which represent a model for diet-induced NIDDM. With a high-energy diet the animals develop hyperglycemia and hyperinsulinemia, whereas those maintained on a low-energy diet remain normoglycemic. Although a large amount of insulin immunoreactivity was detected in beta-cells of the normoglycemic compared to hyperglycemic animals, in situ hybridization for insulin mRNA demonstrated a particularly high signal in the beta-cells of the hyperglycemic animals. By electron microscopy, the beta-cells of normoglycemic animals displayed large accumulations of secretory granules, whereas those of the hyperglycemic animals contained very few granules and large deposits o...","publisher":"SAGE Publications","publication_date":{"day":null,"month":null,"year":1995,"errors":{}},"publication_name":"Journal of Histochemistry \u0026amp; Cytochemistry"},"translated_abstract":"Hyperproinsulinemia is a characteristic feature of non-insulin-dependent diabetes mellitus (NIDDM) caused by pancreatic beta-cell dysfunction through a secretion-related alteration or impaired proinsulin processing. We have investigated the insulin processing and secretion in Psammomys obesus fed with low- and high-energy diets, which represent a model for diet-induced NIDDM. With a high-energy diet the animals develop hyperglycemia and hyperinsulinemia, whereas those maintained on a low-energy diet remain normoglycemic. Although a large amount of insulin immunoreactivity was detected in beta-cells of the normoglycemic compared to hyperglycemic animals, in situ hybridization for insulin mRNA demonstrated a particularly high signal in the beta-cells of the hyperglycemic animals. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="88041559"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/88041559/Fish_Ta_I_Les_Jewish_Gold_Glasses_Revisited"><img alt="Research paper thumbnail of Fish-Ta(I)Les: Jewish Gold-Glasses Revisited" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/88041559/Fish_Ta_I_Les_Jewish_Gold_Glasses_Revisited">Fish-Ta(I)Les: Jewish Gold-Glasses Revisited</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">About five hundred gold-glasses have been found in Roman catacombs, either embedded in the sealin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">About five hundred gold-glasses have been found in Roman catacombs, either embedded in the sealing mortar of the loculi or lying on the ground. Of these objects, fifteen have been identified as Jewish, not by the site of discovery, but by the motifs: the menorah, the Holy Ark, and the four species of plants for Succoth. These elements have been recognized not only as real objects used in synagogue rituals, but also as motifs that bear eschatological and messianic meaning. Yet, the most unusual iconographic motif found on the gold-glasses is the fish on a round table in front of a stibadium , a semicircular banqueting couch. This chapter explores this motif in Jewish art in relation to pagan and Christian iconography. Some observations are also included on the presumed original form of the gold-glasses and their use as well as their relation to Jewish ceremonial customs. Keywords: Christian iconography; gold-glasses; Holy Ark; Jewish art; Jewish ceremonial customs; menorah; messianic...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="88041559"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="88041559"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 88041559; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=88041559]").text(description); $(".js-view-count[data-work-id=88041559]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 88041559; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='88041559']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 88041559, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=88041559]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":88041559,"title":"Fish-Ta(I)Les: Jewish Gold-Glasses Revisited","translated_title":"","metadata":{"abstract":"About five hundred gold-glasses have been found in Roman catacombs, either embedded in the sealing mortar of the loculi or lying on the ground. Of these objects, fifteen have been identified as Jewish, not by the site of discovery, but by the motifs: the menorah, the Holy Ark, and the four species of plants for Succoth. These elements have been recognized not only as real objects used in synagogue rituals, but also as motifs that bear eschatological and messianic meaning. Yet, the most unusual iconographic motif found on the gold-glasses is the fish on a round table in front of a stibadium , a semicircular banqueting couch. This chapter explores this motif in Jewish art in relation to pagan and Christian iconography. Some observations are also included on the presumed original form of the gold-glasses and their use as well as their relation to Jewish ceremonial customs. Keywords: Christian iconography; gold-glasses; Holy Ark; Jewish art; Jewish ceremonial customs; menorah; messianic...","publication_date":{"day":null,"month":null,"year":2008,"errors":{}}},"translated_abstract":"About five hundred gold-glasses have been found in Roman catacombs, either embedded in the sealing mortar of the loculi or lying on the ground. Of these objects, fifteen have been identified as Jewish, not by the site of discovery, but by the motifs: the menorah, the Holy Ark, and the four species of plants for Succoth. These elements have been recognized not only as real objects used in synagogue rituals, but also as motifs that bear eschatological and messianic meaning. Yet, the most unusual iconographic motif found on the gold-glasses is the fish on a round table in front of a stibadium , a semicircular banqueting couch. This chapter explores this motif in Jewish art in relation to pagan and Christian iconography. Some observations are also included on the presumed original form of the gold-glasses and their use as well as their relation to Jewish ceremonial customs. Keywords: Christian iconography; gold-glasses; Holy Ark; Jewish art; Jewish ceremonial customs; menorah; messianic...","internal_url":"https://www.academia.edu/88041559/Fish_Ta_I_Les_Jewish_Gold_Glasses_Revisited","translated_internal_url":"","created_at":"2022-10-06T22:55:52.487-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":15775411,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Fish_Ta_I_Les_Jewish_Gold_Glasses_Revisited","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":15775411,"first_name":"Rivka","middle_initials":null,"last_name":"Ben-Sasson","page_name":"RivkaBenSasson","domain_name":"independent","created_at":"2014-08-28T18:30:33.846-07:00","display_name":"Rivka Ben-Sasson","url":"https://independent.academia.edu/RivkaBenSasson"},"attachments":[],"research_interests":[{"id":1236,"name":"Art","url":"https://www.academia.edu/Documents/in/Art"}],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="40826614"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/40826614/%D7%9C%D7%90_%D7%90%D7%97%D7%93_%D7%9C%D7%90_%D7%A9%D7%A0%D7%99%D7%99%D7%9D_%D7%9C%D7%90_%D7%A9%D7%9C%D7%95%D7%A9%D7%94_%D7%A9%D7%91%D7%A2%D7%AA_%D7%94%D7%9E%D7%99%D7%A0%D7%99%D7%9D_%D7%91%D7%90%D7%95%D7%9E%D7%A0%D7%95%D7%AA_%D7%94%D7%99%D7%94%D7%95%D7%93%D7%99%D7%AA"><img alt="Research paper thumbnail of לא אחד, לא שניים, לא שלושה: שבעת המינים באומנות היהודית" class="work-thumbnail" src="https://attachments.academia-assets.com/61110151/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/40826614/%D7%9C%D7%90_%D7%90%D7%97%D7%93_%D7%9C%D7%90_%D7%A9%D7%A0%D7%99%D7%99%D7%9D_%D7%9C%D7%90_%D7%A9%D7%9C%D7%95%D7%A9%D7%94_%D7%A9%D7%91%D7%A2%D7%AA_%D7%94%D7%9E%D7%99%D7%A0%D7%99%D7%9D_%D7%91%D7%90%D7%95%D7%9E%D7%A0%D7%95%D7%AA_%D7%94%D7%99%D7%94%D7%95%D7%93%D7%99%D7%AA">לא אחד, לא שניים, לא שלושה: שבעת המינים באומנות היהודית</a></div><div class="wp-workCard_item"><span>מורשת ישראל MORESHET ISRAEL</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Not One, Not Two, Not Three: The Seven Species in Jewish Art The term “Seven Species” refers to t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Not One, Not Two, Not Three: The Seven Species in Jewish Art<br />The term “Seven Species” refers to the crops with which the land of Israel was<br />blessed. They are listed in the Bible (Deuteronomy 8:7–8) but are never referred<br />to there as the “Seven Species.” The term first appears in the Mishna (Bikurim<br />1:3) and has been used ever since. This article looks for artistic representations<br />of these species as a defined group. Did they first appear in Jewish art at the same<br />time as the idiomatic phrase?<br />The article shows that to date we have not found all seven species as a group in<br />ancient and old Jewish art; only some of them are found in combination. Furthermore,<br />some of these species are seen in art in Christian churches and in public and private<br />homes. Moreover, grapes, pomegranates and wheat were pagan symbols before they<br />appeared in Jewish or Christian art. Finally, the Seven Species appear in art as a<br />defined group only at the beginning of the twentieth century, along with Zionist<br />settlement in the land of Israel. Since then, they have been common symbols and<br />ornaments in all artistic media and almost all sectors of society.<br />Keywords: Seven Species, Late Antique and Byzantine art, Israeli art</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e6ea34225ef13fa34b49659502420e5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":61110151,"asset_id":40826614,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/61110151/download_file?st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="40826614"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="40826614"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 40826614; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=40826614]").text(description); $(".js-view-count[data-work-id=40826614]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 40826614; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='40826614']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 40826614, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0e6ea34225ef13fa34b49659502420e5" } } $('.js-work-strip[data-work-id=40826614]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":40826614,"title":"לא אחד, לא שניים, לא שלושה: שבעת המינים באומנות היהודית","translated_title":"","metadata":{"abstract":"Not One, Not Two, Not Three: The Seven Species in Jewish Art\nThe term “Seven Species” refers to the crops with which the land of Israel was\nblessed. They are listed in the Bible (Deuteronomy 8:7–8) but are never referred\nto there as the “Seven Species.” The term first appears in the Mishna (Bikurim\n1:3) and has been used ever since. This article looks for artistic representations\nof these species as a defined group. Did they first appear in Jewish art at the same\ntime as the idiomatic phrase?\nThe article shows that to date we have not found all seven species as a group in\nancient and old Jewish art; only some of them are found in combination. Furthermore,\nsome of these species are seen in art in Christian churches and in public and private\nhomes. Moreover, grapes, pomegranates and wheat were pagan symbols before they\nappeared in Jewish or Christian art. Finally, the Seven Species appear in art as a\ndefined group only at the beginning of the twentieth century, along with Zionist\nsettlement in the land of Israel. Since then, they have been common symbols and\nornaments in all artistic media and almost all sectors of society.\nKeywords: Seven Species, Late Antique and Byzantine art, Israeli art","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"מורשת ישראל MORESHET ISRAEL"},"translated_abstract":"Not One, Not Two, Not Three: The Seven Species in Jewish Art\nThe term “Seven Species” refers to the crops with which the land of Israel was\nblessed. They are listed in the Bible (Deuteronomy 8:7–8) but are never referred\nto there as the “Seven Species.” The term first appears in the Mishna (Bikurim\n1:3) and has been used ever since. This article looks for artistic representations\nof these species as a defined group. Did they first appear in Jewish art at the same\ntime as the idiomatic phrase?\nThe article shows that to date we have not found all seven species as a group in\nancient and old Jewish art; only some of them are found in combination. Furthermore,\nsome of these species are seen in art in Christian churches and in public and private\nhomes. Moreover, grapes, pomegranates and wheat were pagan symbols before they\nappeared in Jewish or Christian art. Finally, the Seven Species appear in art as a\ndefined group only at the beginning of the twentieth century, along with Zionist\nsettlement in the land of Israel. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37339843"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37339843/%D7%A4%D7%A8%D7%A7_%D7%94%D7%90%D7%AA%D7%A8%D7%95%D7%92_%D7%97%D7%A1%D7%A8_%D7%A2%D7%9E%D7%95%D7%93_pdf"><img alt="Research paper thumbnail of פרק האתרוג חסר עמוד.pdf" class="work-thumbnail" src="https://attachments.academia-assets.com/57299766/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37339843/%D7%A4%D7%A8%D7%A7_%D7%94%D7%90%D7%AA%D7%A8%D7%95%D7%92_%D7%97%D7%A1%D7%A8_%D7%A2%D7%9E%D7%95%D7%93_pdf">פרק האתרוג חסר עמוד.pdf</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This paper aims to show the etrog representations in art through the centuries. It shows only a f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This paper aims to show the etrog representations in art through the centuries.<br />It shows only a few examples from a variety of media in Jewish art from the very beginning of its appearance in the Late Roman period to the end of the Byzantine era. The paper demonstrates the change in the manner of representation of the etrog from a complex symbol during the byzantine era to a plain illumination during the medieval centuries in different books.<br /> From the modern era there are portraits of orthodox Jewish people with the etrog, and there are a few special boxes that were made especially to keep the etrog.<br />The paper shows that the etrog is represented not only in Jewish art, but also in Christian and secular mosaics in Erets Israel during the byzantine time, and in some Christian paintings in the Renaissance.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2d27e7a940c9bbe4712586e3f1c88c22" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57299766,"asset_id":37339843,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57299766/download_file?st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37339843"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37339843"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37339843; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=37339843]").text(description); $(".js-view-count[data-work-id=37339843]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 37339843; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='37339843']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 37339843, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2d27e7a940c9bbe4712586e3f1c88c22" } } $('.js-work-strip[data-work-id=37339843]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":37339843,"title":"פרק האתרוג חסר עמוד.pdf","translated_title":"","metadata":{"abstract":"This paper aims to show the etrog representations in art through the centuries.\nIt shows only a few examples from a variety of media in Jewish art from the very beginning of its appearance in the Late Roman period to the end of the Byzantine era. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="8120360"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/8120360/New_Records_of_Mosses_from_Israel"><img alt="Research paper thumbnail of New Records of Mosses from Israel" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/8120360/New_Records_of_Mosses_from_Israel">New Records of Mosses from Israel</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RivkaBenSasson">Rivka Ben-Sasson</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/IlanaHerrnstadt">Ilana Herrnstadt</a></span></div><div class="wp-workCard_item"><span>Bryologist</span><span>, 1982</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Beit Shean Valley: opposite Sede Nahum, Kushnir, 1945. Sharon Plain: Ilanot, Crosby &amp;amp;...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Beit Shean Valley: opposite Sede Nahum, Kushnir, 1945. Sharon Plain: Ilanot, Crosby &amp;amp; Herrnstadt 78-18-11. ... Golan Heights: S branch of Wadi Daliyyot, on open basalt soil, 400 m, Crosby &amp;amp; Herrnstadt 79-77-5. Syntrichia echinata (Schiffn.) Herrnst. &amp;amp; Ben-Sasson, comb. nov. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8120360"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8120360"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8120360; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8120360]").text(description); $(".js-view-count[data-work-id=8120360]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8120360; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8120360']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8120360, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=8120360]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8120360,"title":"New Records of Mosses from Israel","translated_title":"","metadata":{"abstract":"... Beit Shean Valley: opposite Sede Nahum, Kushnir, 1945. Sharon Plain: Ilanot, Crosby \u0026amp;amp; Herrnstadt 78-18-11. ... Golan Heights: S branch of Wadi Daliyyot, on open basalt soil, 400 m, Crosby \u0026amp;amp; Herrnstadt 79-77-5. Syntrichia echinata (Schiffn.) Herrnst. \u0026amp;amp; Ben-Sasson, comb. nov. ...","publication_date":{"day":null,"month":null,"year":1982,"errors":{}},"publication_name":"Bryologist"},"translated_abstract":"... Beit Shean Valley: opposite Sede Nahum, Kushnir, 1945. Sharon Plain: Ilanot, Crosby \u0026amp;amp; Herrnstadt 78-18-11. ... Golan Heights: S branch of Wadi Daliyyot, on open basalt soil, 400 m, Crosby \u0026amp;amp; Herrnstadt 79-77-5. Syntrichia echinata (Schiffn.) 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Progression t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Psammomys lapses into fully fledged diabetes when maintained on a high-energy diet. Progression to diabetes has been classified into stage A of normoglycemia and normoinsulinemia (&amp;amp;amp;lt;120 mg/ml and 100 mU/L, respectively); stage B of hyperinsulinemia (100-300 mU/L) with marked insulin resistance in the face of normoglycemia; stage C of pronounced hyperinsulinemia with hyperglycemia &amp;amp;amp;lt; or =500 mg/ml; stage D at 6-10 weeks after stage C, featuring further hyperglycemia and loss of insulin. Insulin resistance expressed in Psammomys at stages B and C was demonstrated by nonsuppression of the hepatic gluconeogenesis enzyme phosphoenolpyruvate carboxykinase by the endogenous hyperinsulinemia and by the reduced capacity of insulin to activate muscle and liver tyrosine kinase of the insulin receptor. Diabetes at stage C, but not at stage D, was fully reversed to stage A by restricting the food ration of animals by half (from 14 to 7 g/day) for 10-14 days. We examined islet beta cells of Psammomys in the four stages of progression to diabetes by staining for insulin as well as for apoptosis by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) and visualizing the biotin-labeled cleavage sites. Psammomys in stage A had insulin-laden beta cells. In stage B, a hypertrophy and partial insulin depletion of beta cells was evident with negative TUNEL staining. In stage C, beta cells were markedly depleted of insulin, and their number within the islets decreased, but the TUNEL staining was virtually negative. In stage D, beta cells were markedly diminished within the islets, almost void of insulin, showing distinct TUNEL staining of beta cells. These results indicate that prolonged exposure of islets to in vivo hyperglycemia with beta-cell overtaxation induces nuclear disintegration with irreversible damage to the insulin-secretion apparatus. This precludes the return to normalcy by restricting the food intake of Psammomys. The appearance of cells with TUNEL-positive staining may serve as a marker of impending irreversibility of nutritionally induced diabetes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8120358"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8120358"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8120358; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8120358]").text(description); $(".js-view-count[data-work-id=8120358]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8120358; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8120358']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8120358, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=8120358]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8120358,"title":"Irreversibility of Nutritionally Induced NIDDM in Psammomys obesus Is Related to β-Cell Apoptosis","translated_title":"","metadata":{"abstract":"Psammomys lapses into fully fledged diabetes when maintained on a high-energy diet. Progression to diabetes has been classified into stage A of normoglycemia and normoinsulinemia (\u0026amp;amp;amp;lt;120 mg/ml and 100 mU/L, respectively); stage B of hyperinsulinemia (100-300 mU/L) with marked insulin resistance in the face of normoglycemia; stage C of pronounced hyperinsulinemia with hyperglycemia \u0026amp;amp;amp;lt; or =500 mg/ml; stage D at 6-10 weeks after stage C, featuring further hyperglycemia and loss of insulin. Insulin resistance expressed in Psammomys at stages B and C was demonstrated by nonsuppression of the hepatic gluconeogenesis enzyme phosphoenolpyruvate carboxykinase by the endogenous hyperinsulinemia and by the reduced capacity of insulin to activate muscle and liver tyrosine kinase of the insulin receptor. Diabetes at stage C, but not at stage D, was fully reversed to stage A by restricting the food ration of animals by half (from 14 to 7 g/day) for 10-14 days. We examined islet beta cells of Psammomys in the four stages of progression to diabetes by staining for insulin as well as for apoptosis by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) and visualizing the biotin-labeled cleavage sites. Psammomys in stage A had insulin-laden beta cells. In stage B, a hypertrophy and partial insulin depletion of beta cells was evident with negative TUNEL staining. In stage C, beta cells were markedly depleted of insulin, and their number within the islets decreased, but the TUNEL staining was virtually negative. In stage D, beta cells were markedly diminished within the islets, almost void of insulin, showing distinct TUNEL staining of beta cells. These results indicate that prolonged exposure of islets to in vivo hyperglycemia with beta-cell overtaxation induces nuclear disintegration with irreversible damage to the insulin-secretion apparatus. This precludes the return to normalcy by restricting the food intake of Psammomys. The appearance of cells with TUNEL-positive staining may serve as a marker of impending irreversibility of nutritionally induced diabetes.","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Pancreas"},"translated_abstract":"Psammomys lapses into fully fledged diabetes when maintained on a high-energy diet. Progression to diabetes has been classified into stage A of normoglycemia and normoinsulinemia (\u0026amp;amp;amp;lt;120 mg/ml and 100 mU/L, respectively); stage B of hyperinsulinemia (100-300 mU/L) with marked insulin resistance in the face of normoglycemia; stage C of pronounced hyperinsulinemia with hyperglycemia \u0026amp;amp;amp;lt; or =500 mg/ml; stage D at 6-10 weeks after stage C, featuring further hyperglycemia and loss of insulin. Insulin resistance expressed in Psammomys at stages B and C was demonstrated by nonsuppression of the hepatic gluconeogenesis enzyme phosphoenolpyruvate carboxykinase by the endogenous hyperinsulinemia and by the reduced capacity of insulin to activate muscle and liver tyrosine kinase of the insulin receptor. Diabetes at stage C, but not at stage D, was fully reversed to stage A by restricting the food ration of animals by half (from 14 to 7 g/day) for 10-14 days. We examined islet beta cells of Psammomys in the four stages of progression to diabetes by staining for insulin as well as for apoptosis by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) and visualizing the biotin-labeled cleavage sites. Psammomys in stage A had insulin-laden beta cells. In stage B, a hypertrophy and partial insulin depletion of beta cells was evident with negative TUNEL staining. In stage C, beta cells were markedly depleted of insulin, and their number within the islets decreased, but the TUNEL staining was virtually negative. In stage D, beta cells were markedly diminished within the islets, almost void of insulin, showing distinct TUNEL staining of beta cells. These results indicate that prolonged exposure of islets to in vivo hyperglycemia with beta-cell overtaxation induces nuclear disintegration with irreversible damage to the insulin-secretion apparatus. This precludes the return to normalcy by restricting the food intake of Psammomys. The appearance of cells with TUNEL-positive staining may serve as a marker of impending irreversibility of nutritionally induced diabetes.","internal_url":"https://www.academia.edu/8120358/Irreversibility_of_Nutritionally_Induced_NIDDM_in_Psammomys_obesus_Is_Related_to_%CE%B2_Cell_Apoptosis","translated_internal_url":"","created_at":"2014-08-28T18:37:16.685-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":15775411,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":28786548,"work_id":8120358,"tagging_user_id":15775411,"tagged_user_id":49209508,"co_author_invite_id":null,"email":"e***d@hadassah.org.il","display_order":0,"name":"Ehud Ziv","title":"Irreversibility of Nutritionally Induced NIDDM in Psammomys obesus Is Related to β-Cell Apoptosis"},{"id":28786550,"work_id":8120358,"tagging_user_id":15775411,"tagged_user_id":35352840,"co_author_invite_id":null,"email":"n***r@yahoo.com","display_order":4194304,"name":"Nazik Arar","title":"Irreversibility of Nutritionally Induced NIDDM in Psammomys obesus Is Related to β-Cell Apoptosis"},{"id":28786551,"work_id":8120358,"tagging_user_id":15775411,"tagged_user_id":null,"co_author_invite_id":6270736,"email":"s***r@md.huji.ac.il","display_order":6291456,"name":"Eleazar Shafrir","title":"Irreversibility of Nutritionally Induced NIDDM in Psammomys obesus Is Related to β-Cell Apoptosis"}],"downloadable_attachments":[],"slug":"Irreversibility_of_Nutritionally_Induced_NIDDM_in_Psammomys_obesus_Is_Related_to_β_Cell_Apoptosis","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":15775411,"first_name":"Rivka","middle_initials":null,"last_name":"Ben-Sasson","page_name":"RivkaBenSasson","domain_name":"independent","created_at":"2014-08-28T18:30:33.846-07:00","display_name":"Rivka Ben-Sasson","url":"https://independent.academia.edu/RivkaBenSasson"},"attachments":[],"research_interests":[{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":51373,"name":"Insulin Resistance","url":"https://www.academia.edu/Documents/in/Insulin_Resistance"},{"id":71300,"name":"Blood Glucose","url":"https://www.academia.edu/Documents/in/Blood_Glucose"},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver"},{"id":92788,"name":"Pancreas","url":"https://www.academia.edu/Documents/in/Pancreas"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus"},{"id":1567539,"name":"Energy Intake","url":"https://www.academia.edu/Documents/in/Energy_Intake"},{"id":1705044,"name":"islets of Langerhans","url":"https://www.academia.edu/Documents/in/islets_of_Langerhans"}],"urls":[{"id":3401189,"url":"http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage\u0026an=00006676-199904000-00007"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="1754795" id="papers"><div class="js-work-strip profile--work_container" data-work-id="115225979"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115225979/The_Etrog_Citron_in_Art"><img alt="Research paper thumbnail of The Etrog Citron in Art" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115225979/The_Etrog_Citron_in_Art">The Etrog Citron in Art</a></div><div class="wp-workCard_item"><span>Springer eBooks</span><span>, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115225979"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115225979"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115225979; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="109832704"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/109832704/Morpho_cytochemical_and_biochemical_evidence_for_insulin_absorption_by_the_rat_ileal_epithelium"><img alt="Research paper thumbnail of Morpho-cytochemical and biochemical evidence for insulin absorption by the rat ileal epithelium" class="work-thumbnail" src="https://attachments.academia-assets.com/107838044/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109832704/Morpho_cytochemical_and_biochemical_evidence_for_insulin_absorption_by_the_rat_ileal_epithelium">Morpho-cytochemical and biochemical evidence for insulin absorption by the rat ileal epithelium</a></div><div class="wp-workCard_item"><span>Diabetologia</span><span>, Apr 1, 1990</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fd33af24aa1ec5cbeeb3ae0b6507b469" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":107838044,"asset_id":109832704,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/107838044/download_file?st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjg0MzI1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109832704"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109832704"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109832704; 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Insulin was introduced into the lumen of the ileum in combination with sodium chelate and aprotinin and allowed to be absorbed for various periods of time. Analysis of blood samples from the inferior vena cava, at different time points has demonstrated an increase in plasma insulin followed by a decrease in blood glucose levels. The ileal tissues were studied at different time points after the introduction of the insulin, by applying the protein A-gold immunocytochemical technique. Insulin antigenic sites were detected with high resolution, at various levels of the enterocytes but were absent from goblet cells. At 2 to 5 min, the labelling was mainly associated with the microvilli and endocytotic vesicles in the apical portion of the epithelial cells. Some gold particles were in contact with the lateral membranes. At 10 min, the labelling was found at the level of the trans-side of the Golgi apparatus and mainly along the base-lateral membranes of the epithelial cells. Labelling was also detected in the interstitial space. The control experiments have demonstrated the specificity of the labelling and confirmed the nature of the insulin molecules detected. Furthermore, the morphological study has confirmed that exposure of the tissue to the insulin-chelate aprotinin solution does not affect the integrity of the epithelium while promoting insulin absorption. Thus, insulin introduced in the lumen of the rat ileum in conjunction with sodium chelate and aprotinin, appears to be rapidly absorbed by the epithelial cells and transferred to the circulation through a transcytotic 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data-work-id="109832703"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/109832703/Biochemical_and_morpho_cytochemical_evidence_for_the_intestinal_absorption_of_insulin_in_control_and_diabetic_rats_Comparison_between_the_effectiveness_of_duodenal_and_colon_mucosa"><img alt="Research paper thumbnail of Biochemical and morpho-cytochemical evidence for the intestinal absorption of insulin in control and diabetic rats. Comparison between the effectiveness of duodenal and colon mucosa" class="work-thumbnail" src="https://attachments.academia-assets.com/107838113/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109832703/Biochemical_and_morpho_cytochemical_evidence_for_the_intestinal_absorption_of_insulin_in_control_and_diabetic_rats_Comparison_between_the_effectiveness_of_duodenal_and_colon_mucosa">Biochemical and morpho-cytochemical evidence for the intestinal absorption of insulin in control and diabetic rats. Comparison between the effectiveness of duodenal and colon mucosa</a></div><div class="wp-workCard_item"><span>Diabetologia</span><span>, Feb 1, 1994</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f91d09a9bc3085399d7aee52949a075d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":107838113,"asset_id":109832703,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/107838113/download_file?st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjg0MzI1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109832703"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109832703"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109832703; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=109832703]").text(description); $(".js-view-count[data-work-id=109832703]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 109832703; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='109832703']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 109832703, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f91d09a9bc3085399d7aee52949a075d" } } $('.js-work-strip[data-work-id=109832703]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":109832703,"title":"Biochemical and morpho-cytochemical evidence for the intestinal absorption of insulin in control and diabetic rats. Comparison between the effectiveness of duodenal and colon mucosa","translated_title":"","metadata":{"publisher":"Springer Science+Business Media","grobid_abstract":"A combined biochemical and morpho-cytochemical investigation was carried out in order to assess insulin absorption by the duodenal and colon epithelium. Insulin was introduced in the lumen of the rat duodenum or colon in combination with sodium cholate and aprotinin. Blood analysis made at several time points has demonstrated a rapid increase in circulating levels of insulin followed by significant and consistent decreases in blood glucose. This indicates that biologically active insulin is absorbed by the intestinal mucosa and transferred to the circulation. Because of the initial high blood glucose levels, the lowering of the glycaemic values was more significant in diabetic animals. Also, levels of circulating insulin remained higher for longer time when the administration was performed in the colon. The integrity of the intestinal wall after insulin administration, evaluated morphologically, was retained. Application of protein A-gold immunocytochemistry has established the pathway for insulin ab","publication_date":{"day":1,"month":2,"year":1994,"errors":{}},"publication_name":"Diabetologia","grobid_abstract_attachment_id":107838113},"translated_abstract":null,"internal_url":"https://www.academia.edu/109832703/Biochemical_and_morpho_cytochemical_evidence_for_the_intestinal_absorption_of_insulin_in_control_and_diabetic_rats_Comparison_between_the_effectiveness_of_duodenal_and_colon_mucosa","translated_internal_url":"","created_at":"2023-11-25T22:10:49.292-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":15775411,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":107838113,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/107838113/thumbnails/1.jpg","file_name":"s001250050081.pdf","download_url":"https://www.academia.edu/attachments/107838113/download_file?st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjg0MzI1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Biochemical_and_morpho_cytochemical_evid.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/107838113/s001250050081-libre.pdf?1700982993=\u0026response-content-disposition=attachment%3B+filename%3DBiochemical_and_morpho_cytochemical_evid.pdf\u0026Expires=1732846856\u0026Signature=Ab5YopEq-G-SqRcfy-fyeEtZeHh7ta~v1DpYdqoH9d51qmdB5qJKSVG4~LYKmsac5~MQuUd5an64QjLbCnhj7aigY9nGWpoPJQMHtlpqlv3amruuz1RmBWnombRLB2RiVtFJcRIn-pZChSqJR9lcJsDY5oJJ77hBpTQUYo-M-TcduvlaesAheSZWvci~x67iSOS~neFmwYvC3W6tjCVmd2mh~zrYtRTmGrxLDWTZCaFQHDbhZENovbDV2W~4CVk6VQjnVZojAoY-GivI0UJI6~cDz7Ha6RrgeGShkkMPgDuoxOmca6eH9XdED56lidXjhAsm1-Ybx8HvX6yvCGMqJQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Biochemical_and_morpho_cytochemical_evidence_for_the_intestinal_absorption_of_insulin_in_control_and_diabetic_rats_Comparison_between_the_effectiveness_of_duodenal_and_colon_mucosa","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":15775411,"first_name":"Rivka","middle_initials":null,"last_name":"Ben-Sasson","page_name":"RivkaBenSasson","domain_name":"independent","created_at":"2014-08-28T18:30:33.846-07:00","display_name":"Rivka 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data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/109832702/Immunocytochemical_investigation_of_insulin_secretion_by_pancreatic_beta_cells_in_control_and_diabetic_Psammomys_obesus"><img alt="Research paper thumbnail of Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus" class="work-thumbnail" src="https://attachments.academia-assets.com/108848461/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109832702/Immunocytochemical_investigation_of_insulin_secretion_by_pancreatic_beta_cells_in_control_and_diabetic_Psammomys_obesus">Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus</a></div><div class="wp-workCard_item"><span>Journal of Histochemistry &amp; Cytochemistry</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Hyperproinsulinemia is a characteristic feature of non-insulin-dependent diabetes mellitus (NIDDM...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hyperproinsulinemia is a characteristic feature of non-insulin-dependent diabetes mellitus (NIDDM) caused by pancreatic beta-cell dysfunction through a secretion-related alteration or impaired proinsulin processing. We have investigated the insulin processing and secretion in Psammomys obesus fed with low- and high-energy diets, which represent a model for diet-induced NIDDM. With a high-energy diet the animals develop hyperglycemia and hyperinsulinemia, whereas those maintained on a low-energy diet remain normoglycemic. Although a large amount of insulin immunoreactivity was detected in beta-cells of the normoglycemic compared to hyperglycemic animals, in situ hybridization for insulin mRNA demonstrated a particularly high signal in the beta-cells of the hyperglycemic animals. By electron microscopy, the beta-cells of normoglycemic animals displayed large accumulations of secretory granules, whereas those of the hyperglycemic animals contained very few granules and large deposits o...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4067b11fca301502569ffb4067fdb66e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108848461,"asset_id":109832702,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108848461/download_file?st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjg0MzI1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109832702"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109832702"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109832702; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=109832702]").text(description); $(".js-view-count[data-work-id=109832702]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 109832702; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='109832702']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 109832702, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4067b11fca301502569ffb4067fdb66e" } } $('.js-work-strip[data-work-id=109832702]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":109832702,"title":"Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus","translated_title":"","metadata":{"abstract":"Hyperproinsulinemia is a characteristic feature of non-insulin-dependent diabetes mellitus (NIDDM) caused by pancreatic beta-cell dysfunction through a secretion-related alteration or impaired proinsulin processing. We have investigated the insulin processing and secretion in Psammomys obesus fed with low- and high-energy diets, which represent a model for diet-induced NIDDM. With a high-energy diet the animals develop hyperglycemia and hyperinsulinemia, whereas those maintained on a low-energy diet remain normoglycemic. Although a large amount of insulin immunoreactivity was detected in beta-cells of the normoglycemic compared to hyperglycemic animals, in situ hybridization for insulin mRNA demonstrated a particularly high signal in the beta-cells of the hyperglycemic animals. By electron microscopy, the beta-cells of normoglycemic animals displayed large accumulations of secretory granules, whereas those of the hyperglycemic animals contained very few granules and large deposits o...","publisher":"SAGE Publications","publication_date":{"day":null,"month":null,"year":1995,"errors":{}},"publication_name":"Journal of Histochemistry \u0026amp; Cytochemistry"},"translated_abstract":"Hyperproinsulinemia is a characteristic feature of non-insulin-dependent diabetes mellitus (NIDDM) caused by pancreatic beta-cell dysfunction through a secretion-related alteration or impaired proinsulin processing. We have investigated the insulin processing and secretion in Psammomys obesus fed with low- and high-energy diets, which represent a model for diet-induced NIDDM. With a high-energy diet the animals develop hyperglycemia and hyperinsulinemia, whereas those maintained on a low-energy diet remain normoglycemic. Although a large amount of insulin immunoreactivity was detected in beta-cells of the normoglycemic compared to hyperglycemic animals, in situ hybridization for insulin mRNA demonstrated a particularly high signal in the beta-cells of the hyperglycemic animals. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103171577"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103171577/%D7%9C%D7%90_%D7%90%D7%97%D7%93_%D7%9C%D7%90_%D7%A9%D7%A0%D7%99%D7%99%D7%9D_%D7%9C%D7%90_%D7%A9%D7%9C%D7%95%D7%A9%D7%94_%D7%A9%D7%91%D7%A2%D7%AA_%D7%94%D7%9E%D7%99%D7%A0%D7%99%D7%9D_%D7%91%D7%90%D7%95%D7%9E%D7%A0%D7%95%D7%AA_%D7%94%D7%99%D7%94%D7%95%D7%93%D7%99%D7%AA"><img alt="Research paper thumbnail of לא אחד, לא שניים, לא שלושה: שבעת המינים באומנות היהודית" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103171577/%D7%9C%D7%90_%D7%90%D7%97%D7%93_%D7%9C%D7%90_%D7%A9%D7%A0%D7%99%D7%99%D7%9D_%D7%9C%D7%90_%D7%A9%D7%9C%D7%95%D7%A9%D7%94_%D7%A9%D7%91%D7%A2%D7%AA_%D7%94%D7%9E%D7%99%D7%A0%D7%99%D7%9D_%D7%91%D7%90%D7%95%D7%9E%D7%A0%D7%95%D7%AA_%D7%94%D7%99%D7%94%D7%95%D7%93%D7%99%D7%AA">לא אחד, לא שניים, לא שלושה: שבעת המינים באומנות היהודית</a></div><div class="wp-workCard_item"><span>Moreshet Israel</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103171577"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103171577"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103171577; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103171564"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103171564/The_Citron_Citrus_medica_L_in_China"><img alt="Research paper thumbnail of The Citron (Citrus medica L.) in China" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103171564/The_Citron_Citrus_medica_L_in_China">The Citron (Citrus medica L.) in China</a></div><div class="wp-workCard_item"><span>The Citron Compendium</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103171564"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103171564"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103171564; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="88041559"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/88041559/Fish_Ta_I_Les_Jewish_Gold_Glasses_Revisited"><img alt="Research paper thumbnail of Fish-Ta(I)Les: Jewish Gold-Glasses Revisited" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/88041559/Fish_Ta_I_Les_Jewish_Gold_Glasses_Revisited">Fish-Ta(I)Les: Jewish Gold-Glasses Revisited</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">About five hundred gold-glasses have been found in Roman catacombs, either embedded in the sealin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">About five hundred gold-glasses have been found in Roman catacombs, either embedded in the sealing mortar of the loculi or lying on the ground. Of these objects, fifteen have been identified as Jewish, not by the site of discovery, but by the motifs: the menorah, the Holy Ark, and the four species of plants for Succoth. These elements have been recognized not only as real objects used in synagogue rituals, but also as motifs that bear eschatological and messianic meaning. Yet, the most unusual iconographic motif found on the gold-glasses is the fish on a round table in front of a stibadium , a semicircular banqueting couch. This chapter explores this motif in Jewish art in relation to pagan and Christian iconography. Some observations are also included on the presumed original form of the gold-glasses and their use as well as their relation to Jewish ceremonial customs. Keywords: Christian iconography; gold-glasses; Holy Ark; Jewish art; Jewish ceremonial customs; menorah; messianic...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="88041559"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="88041559"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 88041559; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=88041559]").text(description); $(".js-view-count[data-work-id=88041559]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 88041559; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='88041559']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 88041559, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=88041559]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":88041559,"title":"Fish-Ta(I)Les: Jewish Gold-Glasses Revisited","translated_title":"","metadata":{"abstract":"About five hundred gold-glasses have been found in Roman catacombs, either embedded in the sealing mortar of the loculi or lying on the ground. Of these objects, fifteen have been identified as Jewish, not by the site of discovery, but by the motifs: the menorah, the Holy Ark, and the four species of plants for Succoth. These elements have been recognized not only as real objects used in synagogue rituals, but also as motifs that bear eschatological and messianic meaning. Yet, the most unusual iconographic motif found on the gold-glasses is the fish on a round table in front of a stibadium , a semicircular banqueting couch. This chapter explores this motif in Jewish art in relation to pagan and Christian iconography. Some observations are also included on the presumed original form of the gold-glasses and their use as well as their relation to Jewish ceremonial customs. Keywords: Christian iconography; gold-glasses; Holy Ark; Jewish art; Jewish ceremonial customs; menorah; messianic...","publication_date":{"day":null,"month":null,"year":2008,"errors":{}}},"translated_abstract":"About five hundred gold-glasses have been found in Roman catacombs, either embedded in the sealing mortar of the loculi or lying on the ground. Of these objects, fifteen have been identified as Jewish, not by the site of discovery, but by the motifs: the menorah, the Holy Ark, and the four species of plants for Succoth. These elements have been recognized not only as real objects used in synagogue rituals, but also as motifs that bear eschatological and messianic meaning. Yet, the most unusual iconographic motif found on the gold-glasses is the fish on a round table in front of a stibadium , a semicircular banqueting couch. This chapter explores this motif in Jewish art in relation to pagan and Christian iconography. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="40826614"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/40826614/%D7%9C%D7%90_%D7%90%D7%97%D7%93_%D7%9C%D7%90_%D7%A9%D7%A0%D7%99%D7%99%D7%9D_%D7%9C%D7%90_%D7%A9%D7%9C%D7%95%D7%A9%D7%94_%D7%A9%D7%91%D7%A2%D7%AA_%D7%94%D7%9E%D7%99%D7%A0%D7%99%D7%9D_%D7%91%D7%90%D7%95%D7%9E%D7%A0%D7%95%D7%AA_%D7%94%D7%99%D7%94%D7%95%D7%93%D7%99%D7%AA"><img alt="Research paper thumbnail of לא אחד, לא שניים, לא שלושה: שבעת המינים באומנות היהודית" class="work-thumbnail" src="https://attachments.academia-assets.com/61110151/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/40826614/%D7%9C%D7%90_%D7%90%D7%97%D7%93_%D7%9C%D7%90_%D7%A9%D7%A0%D7%99%D7%99%D7%9D_%D7%9C%D7%90_%D7%A9%D7%9C%D7%95%D7%A9%D7%94_%D7%A9%D7%91%D7%A2%D7%AA_%D7%94%D7%9E%D7%99%D7%A0%D7%99%D7%9D_%D7%91%D7%90%D7%95%D7%9E%D7%A0%D7%95%D7%AA_%D7%94%D7%99%D7%94%D7%95%D7%93%D7%99%D7%AA">לא אחד, לא שניים, לא שלושה: שבעת המינים באומנות היהודית</a></div><div class="wp-workCard_item"><span>מורשת ישראל MORESHET ISRAEL</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Not One, Not Two, Not Three: The Seven Species in Jewish Art The term “Seven Species” refers to t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Not One, Not Two, Not Three: The Seven Species in Jewish Art<br />The term “Seven Species” refers to the crops with which the land of Israel was<br />blessed. They are listed in the Bible (Deuteronomy 8:7–8) but are never referred<br />to there as the “Seven Species.” The term first appears in the Mishna (Bikurim<br />1:3) and has been used ever since. This article looks for artistic representations<br />of these species as a defined group. Did they first appear in Jewish art at the same<br />time as the idiomatic phrase?<br />The article shows that to date we have not found all seven species as a group in<br />ancient and old Jewish art; only some of them are found in combination. Furthermore,<br />some of these species are seen in art in Christian churches and in public and private<br />homes. Moreover, grapes, pomegranates and wheat were pagan symbols before they<br />appeared in Jewish or Christian art. Finally, the Seven Species appear in art as a<br />defined group only at the beginning of the twentieth century, along with Zionist<br />settlement in the land of Israel. Since then, they have been common symbols and<br />ornaments in all artistic media and almost all sectors of society.<br />Keywords: Seven Species, Late Antique and Byzantine art, Israeli art</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e6ea34225ef13fa34b49659502420e5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":61110151,"asset_id":40826614,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/61110151/download_file?st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="40826614"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="40826614"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 40826614; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=40826614]").text(description); $(".js-view-count[data-work-id=40826614]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 40826614; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='40826614']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 40826614, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0e6ea34225ef13fa34b49659502420e5" } } $('.js-work-strip[data-work-id=40826614]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":40826614,"title":"לא אחד, לא שניים, לא שלושה: שבעת המינים באומנות היהודית","translated_title":"","metadata":{"abstract":"Not One, Not Two, Not Three: The Seven Species in Jewish Art\nThe term “Seven Species” refers to the crops with which the land of Israel was\nblessed. They are listed in the Bible (Deuteronomy 8:7–8) but are never referred\nto there as the “Seven Species.” The term first appears in the Mishna (Bikurim\n1:3) and has been used ever since. This article looks for artistic representations\nof these species as a defined group. Did they first appear in Jewish art at the same\ntime as the idiomatic phrase?\nThe article shows that to date we have not found all seven species as a group in\nancient and old Jewish art; only some of them are found in combination. Furthermore,\nsome of these species are seen in art in Christian churches and in public and private\nhomes. Moreover, grapes, pomegranates and wheat were pagan symbols before they\nappeared in Jewish or Christian art. Finally, the Seven Species appear in art as a\ndefined group only at the beginning of the twentieth century, along with Zionist\nsettlement in the land of Israel. Since then, they have been common symbols and\nornaments in all artistic media and almost all sectors of society.\nKeywords: Seven Species, Late Antique and Byzantine art, Israeli art","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"מורשת ישראל MORESHET ISRAEL"},"translated_abstract":"Not One, Not Two, Not Three: The Seven Species in Jewish Art\nThe term “Seven Species” refers to the crops with which the land of Israel was\nblessed. They are listed in the Bible (Deuteronomy 8:7–8) but are never referred\nto there as the “Seven Species.” The term first appears in the Mishna (Bikurim\n1:3) and has been used ever since. This article looks for artistic representations\nof these species as a defined group. Did they first appear in Jewish art at the same\ntime as the idiomatic phrase?\nThe article shows that to date we have not found all seven species as a group in\nancient and old Jewish art; only some of them are found in combination. Furthermore,\nsome of these species are seen in art in Christian churches and in public and private\nhomes. Moreover, grapes, pomegranates and wheat were pagan symbols before they\nappeared in Jewish or Christian art. Finally, the Seven Species appear in art as a\ndefined group only at the beginning of the twentieth century, along with Zionist\nsettlement in the land of Israel. Since then, they have been common symbols and\nornaments in all artistic media and almost all sectors of society.\nKeywords: Seven Species, Late Antique and Byzantine art, Israeli art","internal_url":"https://www.academia.edu/40826614/%D7%9C%D7%90_%D7%90%D7%97%D7%93_%D7%9C%D7%90_%D7%A9%D7%A0%D7%99%D7%99%D7%9D_%D7%9C%D7%90_%D7%A9%D7%9C%D7%95%D7%A9%D7%94_%D7%A9%D7%91%D7%A2%D7%AA_%D7%94%D7%9E%D7%99%D7%A0%D7%99%D7%9D_%D7%91%D7%90%D7%95%D7%9E%D7%A0%D7%95%D7%AA_%D7%94%D7%99%D7%94%D7%95%D7%93%D7%99%D7%AA","translated_internal_url":"","created_at":"2019-11-03T03:49:29.120-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":15775411,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":61110151,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/61110151/thumbnails/1.jpg","file_name":"מאמר_במורשת_ישראל20191103-100020-1wxhdf.pdf","download_url":"https://www.academia.edu/attachments/61110151/download_file?st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"61110151.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/61110151/%D7%9E%D7%90%D7%9E%D7%A8_%D7%91%D7%9E%D7%95%D7%A8%D7%A9%D7%AA_%D7%99%D7%A9%D7%A8%D7%90%D7%9C20191103-100020-1wxhdf-libre.pdf?1572783257=\u0026response-content-disposition=attachment%3B+filename%3D61110151.pdf\u0026Expires=1732846856\u0026Signature=Cf1n7lL~hKOuUyUq6k4~r3G9YX~De7omiBM5RYzgjUmBUXGnMBtTx8FgkXaOk8CdPSb42qRT3GmaEJep-BPTpJGkGdhxFZ2vcnQ-4k0TtNCFaUcBhsvN7BjqCSGJKUenMTraQe-lZryGTT8C04ESHqRvffY-3ENO498WldpCkdJceCT7E1nLRq34IgZYPxN5SLh~ejPxdQVBuLyKn6AfucME8RMX9t3h6-Zck2xtH9AgL2X8-Z-58fCilVqfnrCxKdaj0bbHxcgWj7NYrcXidBRsx61uelQ9TQVCTgbLkHLO0IFF3QZXC-t3YE2L3UUa8fobMDzGutrAWEvQV3lfjQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"לא_אחד_לא_שניים_לא_שלושה_שבעת_המינים_באומנות_היהודית","translated_slug":"","page_count":20,"language":"he","content_type":"Work","owner":{"id":15775411,"first_name":"Rivka","middle_initials":null,"last_name":"Ben-Sasson","page_name":"RivkaBenSasson","domain_name":"independent","created_at":"2014-08-28T18:30:33.846-07:00","display_name":"Rivka Ben-Sasson","url":"https://independent.academia.edu/RivkaBenSasson"},"attachments":[{"id":61110151,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/61110151/thumbnails/1.jpg","file_name":"מאמר_במורשת_ישראל20191103-100020-1wxhdf.pdf","download_url":"https://www.academia.edu/attachments/61110151/download_file?st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"61110151.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/61110151/%D7%9E%D7%90%D7%9E%D7%A8_%D7%91%D7%9E%D7%95%D7%A8%D7%A9%D7%AA_%D7%99%D7%A9%D7%A8%D7%90%D7%9C20191103-100020-1wxhdf-libre.pdf?1572783257=\u0026response-content-disposition=attachment%3B+filename%3D61110151.pdf\u0026Expires=1732846856\u0026Signature=Cf1n7lL~hKOuUyUq6k4~r3G9YX~De7omiBM5RYzgjUmBUXGnMBtTx8FgkXaOk8CdPSb42qRT3GmaEJep-BPTpJGkGdhxFZ2vcnQ-4k0TtNCFaUcBhsvN7BjqCSGJKUenMTraQe-lZryGTT8C04ESHqRvffY-3ENO498WldpCkdJceCT7E1nLRq34IgZYPxN5SLh~ejPxdQVBuLyKn6AfucME8RMX9t3h6-Zck2xtH9AgL2X8-Z-58fCilVqfnrCxKdaj0bbHxcgWj7NYrcXidBRsx61uelQ9TQVCTgbLkHLO0IFF3QZXC-t3YE2L3UUa8fobMDzGutrAWEvQV3lfjQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37339843"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37339843/%D7%A4%D7%A8%D7%A7_%D7%94%D7%90%D7%AA%D7%A8%D7%95%D7%92_%D7%97%D7%A1%D7%A8_%D7%A2%D7%9E%D7%95%D7%93_pdf"><img alt="Research paper thumbnail of פרק האתרוג חסר עמוד.pdf" class="work-thumbnail" src="https://attachments.academia-assets.com/57299766/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37339843/%D7%A4%D7%A8%D7%A7_%D7%94%D7%90%D7%AA%D7%A8%D7%95%D7%92_%D7%97%D7%A1%D7%A8_%D7%A2%D7%9E%D7%95%D7%93_pdf">פרק האתרוג חסר עמוד.pdf</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This paper aims to show the etrog representations in art through the centuries. It shows only a f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This paper aims to show the etrog representations in art through the centuries.<br />It shows only a few examples from a variety of media in Jewish art from the very beginning of its appearance in the Late Roman period to the end of the Byzantine era. The paper demonstrates the change in the manner of representation of the etrog from a complex symbol during the byzantine era to a plain illumination during the medieval centuries in different books.<br /> From the modern era there are portraits of orthodox Jewish people with the etrog, and there are a few special boxes that were made especially to keep the etrog.<br />The paper shows that the etrog is represented not only in Jewish art, but also in Christian and secular mosaics in Erets Israel during the byzantine time, and in some Christian paintings in the Renaissance.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2d27e7a940c9bbe4712586e3f1c88c22" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57299766,"asset_id":37339843,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57299766/download_file?st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjg0MzI1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37339843"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37339843"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37339843; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=37339843]").text(description); $(".js-view-count[data-work-id=37339843]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 37339843; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='37339843']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 37339843, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2d27e7a940c9bbe4712586e3f1c88c22" } } $('.js-work-strip[data-work-id=37339843]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":37339843,"title":"פרק האתרוג חסר עמוד.pdf","translated_title":"","metadata":{"abstract":"This paper aims to show the etrog representations in art through the centuries.\nIt shows only a few examples from a variety of media in Jewish art from the very beginning of its appearance in the Late Roman period to the end of the Byzantine era. The paper demonstrates the change in the manner of representation of the etrog from a complex symbol during the byzantine era to a plain illumination during the medieval centuries in different books.\n From the modern era there are portraits of orthodox Jewish people with the etrog, and there are a few special boxes that were made especially to keep the etrog.\nThe paper shows that the etrog is represented not only in Jewish art, but also in Christian and secular mosaics in Erets Israel during the byzantine time, and in some Christian paintings in the Renaissance.\n \n"},"translated_abstract":"This paper aims to show the etrog representations in art through the centuries.\nIt shows only a few examples from a variety of media in Jewish art from the very beginning of its appearance in the Late Roman period to the end of the Byzantine era. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="8120360"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/8120360/New_Records_of_Mosses_from_Israel"><img alt="Research paper thumbnail of New Records of Mosses from Israel" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/8120360/New_Records_of_Mosses_from_Israel">New Records of Mosses from Israel</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RivkaBenSasson">Rivka Ben-Sasson</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/IlanaHerrnstadt">Ilana Herrnstadt</a></span></div><div class="wp-workCard_item"><span>Bryologist</span><span>, 1982</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Beit Shean Valley: opposite Sede Nahum, Kushnir, 1945. Sharon Plain: Ilanot, Crosby &amp;amp;...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Beit Shean Valley: opposite Sede Nahum, Kushnir, 1945. Sharon Plain: Ilanot, Crosby &amp;amp; Herrnstadt 78-18-11. ... Golan Heights: S branch of Wadi Daliyyot, on open basalt soil, 400 m, Crosby &amp;amp; Herrnstadt 79-77-5. Syntrichia echinata (Schiffn.) Herrnst. &amp;amp; Ben-Sasson, comb. nov. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8120360"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8120360"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8120360; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8120360]").text(description); $(".js-view-count[data-work-id=8120360]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8120360; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8120360']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8120360, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=8120360]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8120360,"title":"New Records of Mosses from Israel","translated_title":"","metadata":{"abstract":"... Beit Shean Valley: opposite Sede Nahum, Kushnir, 1945. Sharon Plain: Ilanot, Crosby \u0026amp;amp; Herrnstadt 78-18-11. ... Golan Heights: S branch of Wadi Daliyyot, on open basalt soil, 400 m, Crosby \u0026amp;amp; Herrnstadt 79-77-5. Syntrichia echinata (Schiffn.) Herrnst. \u0026amp;amp; Ben-Sasson, comb. nov. ...","publication_date":{"day":null,"month":null,"year":1982,"errors":{}},"publication_name":"Bryologist"},"translated_abstract":"... Beit Shean Valley: opposite Sede Nahum, Kushnir, 1945. Sharon Plain: Ilanot, Crosby \u0026amp;amp; Herrnstadt 78-18-11. ... Golan Heights: S branch of Wadi Daliyyot, on open basalt soil, 400 m, Crosby \u0026amp;amp; Herrnstadt 79-77-5. Syntrichia echinata (Schiffn.) 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Progression t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Psammomys lapses into fully fledged diabetes when maintained on a high-energy diet. Progression to diabetes has been classified into stage A of normoglycemia and normoinsulinemia (&amp;amp;amp;lt;120 mg/ml and 100 mU/L, respectively); stage B of hyperinsulinemia (100-300 mU/L) with marked insulin resistance in the face of normoglycemia; stage C of pronounced hyperinsulinemia with hyperglycemia &amp;amp;amp;lt; or =500 mg/ml; stage D at 6-10 weeks after stage C, featuring further hyperglycemia and loss of insulin. Insulin resistance expressed in Psammomys at stages B and C was demonstrated by nonsuppression of the hepatic gluconeogenesis enzyme phosphoenolpyruvate carboxykinase by the endogenous hyperinsulinemia and by the reduced capacity of insulin to activate muscle and liver tyrosine kinase of the insulin receptor. Diabetes at stage C, but not at stage D, was fully reversed to stage A by restricting the food ration of animals by half (from 14 to 7 g/day) for 10-14 days. We examined islet beta cells of Psammomys in the four stages of progression to diabetes by staining for insulin as well as for apoptosis by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) and visualizing the biotin-labeled cleavage sites. Psammomys in stage A had insulin-laden beta cells. In stage B, a hypertrophy and partial insulin depletion of beta cells was evident with negative TUNEL staining. In stage C, beta cells were markedly depleted of insulin, and their number within the islets decreased, but the TUNEL staining was virtually negative. In stage D, beta cells were markedly diminished within the islets, almost void of insulin, showing distinct TUNEL staining of beta cells. These results indicate that prolonged exposure of islets to in vivo hyperglycemia with beta-cell overtaxation induces nuclear disintegration with irreversible damage to the insulin-secretion apparatus. This precludes the return to normalcy by restricting the food intake of Psammomys. The appearance of cells with TUNEL-positive staining may serve as a marker of impending irreversibility of nutritionally induced diabetes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8120358"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8120358"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8120358; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8120358]").text(description); $(".js-view-count[data-work-id=8120358]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8120358; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8120358']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8120358, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=8120358]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8120358,"title":"Irreversibility of Nutritionally Induced NIDDM in Psammomys obesus Is Related to β-Cell Apoptosis","translated_title":"","metadata":{"abstract":"Psammomys lapses into fully fledged diabetes when maintained on a high-energy diet. Progression to diabetes has been classified into stage A of normoglycemia and normoinsulinemia (\u0026amp;amp;amp;lt;120 mg/ml and 100 mU/L, respectively); stage B of hyperinsulinemia (100-300 mU/L) with marked insulin resistance in the face of normoglycemia; stage C of pronounced hyperinsulinemia with hyperglycemia \u0026amp;amp;amp;lt; or =500 mg/ml; stage D at 6-10 weeks after stage C, featuring further hyperglycemia and loss of insulin. Insulin resistance expressed in Psammomys at stages B and C was demonstrated by nonsuppression of the hepatic gluconeogenesis enzyme phosphoenolpyruvate carboxykinase by the endogenous hyperinsulinemia and by the reduced capacity of insulin to activate muscle and liver tyrosine kinase of the insulin receptor. Diabetes at stage C, but not at stage D, was fully reversed to stage A by restricting the food ration of animals by half (from 14 to 7 g/day) for 10-14 days. We examined islet beta cells of Psammomys in the four stages of progression to diabetes by staining for insulin as well as for apoptosis by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) and visualizing the biotin-labeled cleavage sites. Psammomys in stage A had insulin-laden beta cells. In stage B, a hypertrophy and partial insulin depletion of beta cells was evident with negative TUNEL staining. In stage C, beta cells were markedly depleted of insulin, and their number within the islets decreased, but the TUNEL staining was virtually negative. In stage D, beta cells were markedly diminished within the islets, almost void of insulin, showing distinct TUNEL staining of beta cells. These results indicate that prolonged exposure of islets to in vivo hyperglycemia with beta-cell overtaxation induces nuclear disintegration with irreversible damage to the insulin-secretion apparatus. This precludes the return to normalcy by restricting the food intake of Psammomys. The appearance of cells with TUNEL-positive staining may serve as a marker of impending irreversibility of nutritionally induced diabetes.","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Pancreas"},"translated_abstract":"Psammomys lapses into fully fledged diabetes when maintained on a high-energy diet. Progression to diabetes has been classified into stage A of normoglycemia and normoinsulinemia (\u0026amp;amp;amp;lt;120 mg/ml and 100 mU/L, respectively); stage B of hyperinsulinemia (100-300 mU/L) with marked insulin resistance in the face of normoglycemia; stage C of pronounced hyperinsulinemia with hyperglycemia \u0026amp;amp;amp;lt; or =500 mg/ml; stage D at 6-10 weeks after stage C, featuring further hyperglycemia and loss of insulin. Insulin resistance expressed in Psammomys at stages B and C was demonstrated by nonsuppression of the hepatic gluconeogenesis enzyme phosphoenolpyruvate carboxykinase by the endogenous hyperinsulinemia and by the reduced capacity of insulin to activate muscle and liver tyrosine kinase of the insulin receptor. Diabetes at stage C, but not at stage D, was fully reversed to stage A by restricting the food ration of animals by half (from 14 to 7 g/day) for 10-14 days. We examined islet beta cells of Psammomys in the four stages of progression to diabetes by staining for insulin as well as for apoptosis by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) and visualizing the biotin-labeled cleavage sites. Psammomys in stage A had insulin-laden beta cells. In stage B, a hypertrophy and partial insulin depletion of beta cells was evident with negative TUNEL staining. In stage C, beta cells were markedly depleted of insulin, and their number within the islets decreased, but the TUNEL staining was virtually negative. In stage D, beta cells were markedly diminished within the islets, almost void of insulin, showing distinct TUNEL staining of beta cells. These results indicate that prolonged exposure of islets to in vivo hyperglycemia with beta-cell overtaxation induces nuclear disintegration with irreversible damage to the insulin-secretion apparatus. This precludes the return to normalcy by restricting the food intake of Psammomys. The appearance of cells with TUNEL-positive staining may serve as a marker of impending irreversibility of nutritionally induced diabetes.","internal_url":"https://www.academia.edu/8120358/Irreversibility_of_Nutritionally_Induced_NIDDM_in_Psammomys_obesus_Is_Related_to_%CE%B2_Cell_Apoptosis","translated_internal_url":"","created_at":"2014-08-28T18:37:16.685-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":15775411,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":28786548,"work_id":8120358,"tagging_user_id":15775411,"tagged_user_id":49209508,"co_author_invite_id":null,"email":"e***d@hadassah.org.il","display_order":0,"name":"Ehud Ziv","title":"Irreversibility of Nutritionally Induced NIDDM in Psammomys obesus Is Related to β-Cell Apoptosis"},{"id":28786550,"work_id":8120358,"tagging_user_id":15775411,"tagged_user_id":35352840,"co_author_invite_id":null,"email":"n***r@yahoo.com","display_order":4194304,"name":"Nazik Arar","title":"Irreversibility of Nutritionally Induced NIDDM in Psammomys obesus Is Related to β-Cell Apoptosis"},{"id":28786551,"work_id":8120358,"tagging_user_id":15775411,"tagged_user_id":null,"co_author_invite_id":6270736,"email":"s***r@md.huji.ac.il","display_order":6291456,"name":"Eleazar Shafrir","title":"Irreversibility of Nutritionally Induced NIDDM in Psammomys obesus Is Related to β-Cell Apoptosis"}],"downloadable_attachments":[],"slug":"Irreversibility_of_Nutritionally_Induced_NIDDM_in_Psammomys_obesus_Is_Related_to_β_Cell_Apoptosis","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":15775411,"first_name":"Rivka","middle_initials":null,"last_name":"Ben-Sasson","page_name":"RivkaBenSasson","domain_name":"independent","created_at":"2014-08-28T18:30:33.846-07:00","display_name":"Rivka Ben-Sasson","url":"https://independent.academia.edu/RivkaBenSasson"},"attachments":[],"research_interests":[{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":51373,"name":"Insulin Resistance","url":"https://www.academia.edu/Documents/in/Insulin_Resistance"},{"id":71300,"name":"Blood Glucose","url":"https://www.academia.edu/Documents/in/Blood_Glucose"},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver"},{"id":92788,"name":"Pancreas","url":"https://www.academia.edu/Documents/in/Pancreas"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus"},{"id":1567539,"name":"Energy Intake","url":"https://www.academia.edu/Documents/in/Energy_Intake"},{"id":1705044,"name":"islets of Langerhans","url":"https://www.academia.edu/Documents/in/islets_of_Langerhans"}],"urls":[{"id":3401189,"url":"http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage\u0026an=00006676-199904000-00007"}]}, dispatcherData: dispatcherData }); 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