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js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Galina Racheva</h3></div><div class="js-work-strip profile--work_container" data-work-id="124124936"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124124936/Research_of_the_Potential_Radioprotective_Activity_of_Trimethyl_Glycine_and_N_Acetyl_L_Cysteine_with_Quantitative_Analysis_Using_Real_Time_Polymerase_Chain_Reaction_QRT_PCR_"><img alt="Research paper thumbnail of Research of the Potential Radioprotective Activity of Trimethyl Glycine and N-Acetyl-L-Cysteine with Quantitative Analysis Using Real-Time Polymerase Chain Reaction (QRT-PCR)" class="work-thumbnail" src="https://attachments.academia-assets.com/118405599/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a 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src="https://attachments.academia-assets.com/117919757/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123503848/Different_aspects_of_the_assessment_observation_and_medical_treatment_of_the_acute_radiation_syndrome">Different aspects of the assessment, observation and medical treatment of the acute radiation syndrome</a></div><div class="wp-workCard_item"><span>BULGARIAN MEDICINE</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute radiation syndrome is a special medical condition that combines symptoms of four different ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute radiation syndrome is a special medical<br />condition that combines symptoms of four<br />different sub-syndromes combined or separately.<br />The assessment of the acute radiation<br />syndrome follow strictly defined protocol<br />approved by IAEA. The most important part of<br />the assessment is to calculate the absorbed<br />dose after the exposure and the type of the<br />irradiation such as whole-body or significant<br />partial body exposure to over limited dose (><br />1 Gy absorbed dose). The next step is the<br />medical treatment of the patient. The treatment<br />of the acute radition syndrome depends<br />on the patient condition, dose rate and the<br />type of irradiation. Patients who received a<br />high dose and whole body irradiation (> 1Gy<br />and < 10 Gy) are going to be triage to three<br />different groups: patients, who recover with<br />minimum interventions, those who require<br />aggressive supportive treatment such as<br />bone-marrow transplantation and those, who<br />will receive palliative care. The possibility of<br />local or systematic infection increased with the irradiation, because of the appeared damages<br />in the cutaneous and mucosal barriers<br />and immune system suppression. To prevent<br />the risk of infections in the medical treatment<br />scheme have to be included antibiotics, an<br />antiviral and antifungal drugs. The application<br />of the antimicrobial drugs follow three different<br />approaches depends on the medical condition<br />of the patient.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8b8fe696806d9029d3f81ec078723177" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117919757,"asset_id":123503848,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117919757/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123503848"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123503848"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123503848; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123503848]").text(description); $(".js-view-count[data-work-id=123503848]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123503848; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123503848']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123503848, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8b8fe696806d9029d3f81ec078723177" } } $('.js-work-strip[data-work-id=123503848]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123503848,"title":"Different aspects of the assessment, observation and medical treatment of the acute radiation syndrome","translated_title":"","metadata":{"abstract":"Acute radiation syndrome is a special medical\ncondition that combines symptoms of four\ndifferent sub-syndromes combined or separately.\nThe assessment of the acute radiation\nsyndrome follow strictly defined protocol\napproved by IAEA. 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To prevent\nthe risk of infections in the medical treatment\nscheme have to be included antibiotics, an\nantiviral and antifungal drugs. The application\nof the antimicrobial drugs follow three different\napproaches depends on the medical condition\nof the patient.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"BULGARIAN MEDICINE"},"translated_abstract":"Acute radiation syndrome is a special medical\ncondition that combines symptoms of four\ndifferent sub-syndromes combined or separately.\nThe assessment of the acute radiation\nsyndrome follow strictly defined protocol\napproved by IAEA. The most important part of\nthe assessment is to calculate the absorbed\ndose after the exposure and the type of the\nirradiation such as whole-body or significant\npartial body exposure to over limited dose (\u003e\n1 Gy absorbed dose). The next step is the\nmedical treatment of the patient. The treatment\nof the acute radition syndrome depends\non the patient condition, dose rate and the\ntype of irradiation. Patients who received a\nhigh dose and whole body irradiation (\u003e 1Gy\nand \u003c 10 Gy) are going to be triage to three\ndifferent groups: patients, who recover with\nminimum interventions, those who require\naggressive supportive treatment such as\nbone-marrow transplantation and those, who\nwill receive palliative care. The possibility of\nlocal or systematic infection increased with the irradiation, because of the appeared damages\nin the cutaneous and mucosal barriers\nand immune system suppression. To prevent\nthe risk of infections in the medical treatment\nscheme have to be included antibiotics, an\nantiviral and antifungal drugs. The application\nof the antimicrobial drugs follow three different\napproaches depends on the medical condition\nof the patient.","internal_url":"https://www.academia.edu/123503848/Different_aspects_of_the_assessment_observation_and_medical_treatment_of_the_acute_radiation_syndrome","translated_internal_url":"","created_at":"2024-09-03T00:43:08.345-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42319310,"work_id":123503848,"tagging_user_id":298664184,"tagged_user_id":300103645,"co_author_invite_id":null,"email":"i***v@gmail.com","display_order":1,"name":"Ivan Kindekov","title":"Different aspects of the assessment, observation and medical treatment of the acute radiation syndrome"},{"id":42325158,"work_id":123503848,"tagging_user_id":298664184,"tagged_user_id":298664184,"co_author_invite_id":8233017,"email":"g***a@gmail.com","affiliation":"Military Medical Academy","display_order":1073741824,"name":"Galina Racheva","title":"Different aspects of the assessment, observation and medical treatment of the acute radiation syndrome"}],"downloadable_attachments":[{"id":117919757,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919757/thumbnails/1.jpg","file_name":"spisanie_balgarska_medicina_br_01_2020.pdf","download_url":"https://www.academia.edu/attachments/117919757/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Different_aspects_of_the_assessment_obse.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919757/spisanie_balgarska_medicina_br_01_2020-libre.pdf?1725352819=\u0026response-content-disposition=attachment%3B+filename%3DDifferent_aspects_of_the_assessment_obse.pdf\u0026Expires=1732831889\u0026Signature=Ls3Nt9J-ARrMFZiDegX40jNYiOnCVbYPFbAbnlDAiOo7TxPZ0zTn872nnEzwAVOsYEq7gTp2~en3CHVJe2gsTZE9UML5tVyDxGFD0ptilfyS57mW68lGK3mm6mLhnx4tLQ5sDFobhPNsAsRNf7l~lo4XvidyRSohmnStbwSS0WjrwaQo~I-dZWY1YOW21oyF5iysvqu9Ch4aENKvaeCdW0Kr3fnuXN9uQu4c4irtHZigjks-rn5bFvjDnWXxzBJqu808W0FuphmnokQdJPS6SbUItXs6MRNzAvcIYuDiAztQeb23P2~psgN9PzbCE3RWrUpQ16CmiLcBbvzRyuCBXA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Different_aspects_of_the_assessment_observation_and_medical_treatment_of_the_acute_radiation_syndrome","translated_slug":"","page_count":60,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117919757,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919757/thumbnails/1.jpg","file_name":"spisanie_balgarska_medicina_br_01_2020.pdf","download_url":"https://www.academia.edu/attachments/117919757/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Different_aspects_of_the_assessment_obse.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919757/spisanie_balgarska_medicina_br_01_2020-libre.pdf?1725352819=\u0026response-content-disposition=attachment%3B+filename%3DDifferent_aspects_of_the_assessment_obse.pdf\u0026Expires=1732831889\u0026Signature=Ls3Nt9J-ARrMFZiDegX40jNYiOnCVbYPFbAbnlDAiOo7TxPZ0zTn872nnEzwAVOsYEq7gTp2~en3CHVJe2gsTZE9UML5tVyDxGFD0ptilfyS57mW68lGK3mm6mLhnx4tLQ5sDFobhPNsAsRNf7l~lo4XvidyRSohmnStbwSS0WjrwaQo~I-dZWY1YOW21oyF5iysvqu9Ch4aENKvaeCdW0Kr3fnuXN9uQu4c4irtHZigjks-rn5bFvjDnWXxzBJqu808W0FuphmnokQdJPS6SbUItXs6MRNzAvcIYuDiAztQeb23P2~psgN9PzbCE3RWrUpQ16CmiLcBbvzRyuCBXA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology"},{"id":18325,"name":"Radiobiology of Ionizing Radiation","url":"https://www.academia.edu/Documents/in/Radiobiology_of_Ionizing_Radiation"},{"id":132620,"name":"Radiobiology","url":"https://www.academia.edu/Documents/in/Radiobiology"}],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123503662"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123503662/COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RADIOPROTECTIVE_EFFECT_OF_NATURAL_MODULATORS_OF_BIOLOGICAL_RESPONSE_N_ACETYL_L_CYSTEINE_AND_%CE%B1_LIPOIC_ACID_PREVENTIVELY_ADMINISTERED_IN_AN_EXPERIMENTAL_LYMPHOCYTE_CELLULAR_MODEL"><img alt="Research paper thumbnail of COMPARATIVE CYTOGENETIC STUDY OF THE RADIOPROTECTIVE EFFECT OF NATURAL MODULATORS OF BIOLOGICAL RESPONSE N-ACETYL-L-CYSTEINE AND α-LIPOIC ACID PREVENTIVELY ADMINISTERED IN AN EXPERIMENTAL LYMPHOCYTE CELLULAR MODEL" class="work-thumbnail" src="https://attachments.academia-assets.com/117919597/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123503662/COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RADIOPROTECTIVE_EFFECT_OF_NATURAL_MODULATORS_OF_BIOLOGICAL_RESPONSE_N_ACETYL_L_CYSTEINE_AND_%CE%B1_LIPOIC_ACID_PREVENTIVELY_ADMINISTERED_IN_AN_EXPERIMENTAL_LYMPHOCYTE_CELLULAR_MODEL">COMPARATIVE CYTOGENETIC STUDY OF THE RADIOPROTECTIVE EFFECT OF NATURAL MODULATORS OF BIOLOGICAL RESPONSE N-ACETYL-L-CYSTEINE AND α-LIPOIC ACID PREVENTIVELY ADMINISTERED IN AN EXPERIMENTAL LYMPHOCYTE CELLULAR MODEL</a></div><div class="wp-workCard_item"><span>MILITARY MEDICINE OFFICIAL EDITION OF MILITARY MEDICAL ACADEMY AND BULGARIAN SCIENTIFIC SOCIETY OF MILITARY MEDICINE</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Most of the cellular damages and the development of radiation- induced cellular pathology are ind...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Most of the cellular damages and the development of radiation-<br />induced cellular pathology are indirect effects caused by free<br />radicals. Oxidative damage is the result of the reactive oxygen<br />species generated by ionizing radiation. This perspective is at<br />the heart of research and development of tools that can provide<br />a longer window of protection against lethal damage and other<br />effects resulting from low-dose irradiation in professional groups,<br />diagnostic and therapeutic procedures. A major focus in radiobiology<br />is the study of substances capable of trapping free radicals<br />or preventing their expression, with minimal or no toxic effects.<br />Many natural antioxidants, such as N-Acetyl-L-cysteine and α-Lipoic<br />acid, have antimutagenic properties and have radioprotective<br />potential. They act as modulators of the biological response<br />(immunomodulators) and can redirect the cell to apoptosis in the<br />event of neoplastic transformation. The aim of the study was to<br />compare the potential radioprotective ability of the two native immunomodulators,<br />administered before irradiation, separately and<br />in combination, with a 1Gy absorbed dose in an experimental human<br />lymphocyte cell model. Biodosimetric method of cytogenetic<br />analysis of metaphase chromosomes were used to determine<br />the presence of radiation-induced dicentric and circular chromosomes.<br />Survey results showed radioprotective effect. Reducing<br />the number of chromosomal aberrations correlates with the radioprotective<br />ability of the two native antioxidants to reduce the risk<br />of radiation damage.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="209a731538ad8fec98f9a3d0acd76c4c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117919597,"asset_id":123503662,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117919597/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123503662"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123503662"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123503662; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123503662]").text(description); $(".js-view-count[data-work-id=123503662]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123503662; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123503662']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123503662, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "209a731538ad8fec98f9a3d0acd76c4c" } } $('.js-work-strip[data-work-id=123503662]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123503662,"title":"COMPARATIVE CYTOGENETIC STUDY OF THE RADIOPROTECTIVE EFFECT OF NATURAL MODULATORS OF BIOLOGICAL RESPONSE N-ACETYL-L-CYSTEINE AND α-LIPOIC ACID PREVENTIVELY ADMINISTERED IN AN EXPERIMENTAL LYMPHOCYTE CELLULAR MODEL","translated_title":"","metadata":{"abstract":"Most of the cellular damages and the development of radiation-\ninduced cellular pathology are indirect effects caused by free\nradicals. Oxidative damage is the result of the reactive oxygen\nspecies generated by ionizing radiation. This perspective is at\nthe heart of research and development of tools that can provide\na longer window of protection against lethal damage and other\neffects resulting from low-dose irradiation in professional groups,\ndiagnostic and therapeutic procedures. A major focus in radiobiology\nis the study of substances capable of trapping free radicals\nor preventing their expression, with minimal or no toxic effects.\nMany natural antioxidants, such as N-Acetyl-L-cysteine and α-Lipoic\nacid, have antimutagenic properties and have radioprotective\npotential. They act as modulators of the biological response\n(immunomodulators) and can redirect the cell to apoptosis in the\nevent of neoplastic transformation. The aim of the study was to\ncompare the potential radioprotective ability of the two native immunomodulators,\nadministered before irradiation, separately and\nin combination, with a 1Gy absorbed dose in an experimental human\nlymphocyte cell model. Biodosimetric method of cytogenetic\nanalysis of metaphase chromosomes were used to determine\nthe presence of radiation-induced dicentric and circular chromosomes.\nSurvey results showed radioprotective effect. Reducing\nthe number of chromosomal aberrations correlates with the radioprotective\nability of the two native antioxidants to reduce the risk\nof radiation damage.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"MILITARY MEDICINE OFFICIAL EDITION OF MILITARY MEDICAL ACADEMY AND BULGARIAN SCIENTIFIC SOCIETY OF MILITARY MEDICINE"},"translated_abstract":"Most of the cellular damages and the development of radiation-\ninduced cellular pathology are indirect effects caused by free\nradicals. Oxidative damage is the result of the reactive oxygen\nspecies generated by ionizing radiation. This perspective is at\nthe heart of research and development of tools that can provide\na longer window of protection against lethal damage and other\neffects resulting from low-dose irradiation in professional groups,\ndiagnostic and therapeutic procedures. A major focus in radiobiology\nis the study of substances capable of trapping free radicals\nor preventing their expression, with minimal or no toxic effects.\nMany natural antioxidants, such as N-Acetyl-L-cysteine and α-Lipoic\nacid, have antimutagenic properties and have radioprotective\npotential. They act as modulators of the biological response\n(immunomodulators) and can redirect the cell to apoptosis in the\nevent of neoplastic transformation. The aim of the study was to\ncompare the potential radioprotective ability of the two native immunomodulators,\nadministered before irradiation, separately and\nin combination, with a 1Gy absorbed dose in an experimental human\nlymphocyte cell model. Biodosimetric method of cytogenetic\nanalysis of metaphase chromosomes were used to determine\nthe presence of radiation-induced dicentric and circular chromosomes.\nSurvey results showed radioprotective effect. Reducing\nthe number of chromosomal aberrations correlates with the radioprotective\nability of the two native antioxidants to reduce the risk\nof radiation damage.","internal_url":"https://www.academia.edu/123503662/COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RADIOPROTECTIVE_EFFECT_OF_NATURAL_MODULATORS_OF_BIOLOGICAL_RESPONSE_N_ACETYL_L_CYSTEINE_AND_%CE%B1_LIPOIC_ACID_PREVENTIVELY_ADMINISTERED_IN_AN_EXPERIMENTAL_LYMPHOCYTE_CELLULAR_MODEL","translated_internal_url":"","created_at":"2024-09-03T00:35:14.077-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":117919597,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919597/thumbnails/1.jpg","file_name":"899.pdf","download_url":"https://www.academia.edu/attachments/117919597/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RAD.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919597/899-libre.pdf?1725352501=\u0026response-content-disposition=attachment%3B+filename%3DCOMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RAD.pdf\u0026Expires=1732831889\u0026Signature=Nq1~45bYHmf7ukBGTxfKiMZlGFD4H9Q7daZ4hML1ERJJ6M-a~-HPF7JYF6WWVSebeNk7chnQGEeKL6ef6GcuyS13QaDwHOckZY8AwwoWnYD2T2AmRDyiAY8eJGWDzHXEoxEJrUd~7lm8rgYywFreIOh2fRdQ9Yz4lPAh5r~~NgJVdDXEgeXAQLS8LmUlwmeztw531OxkrBc03T0zMQnGqc0sWasDRoG1r0swJLn-UZCwGLToZEyfu0F6EzNqVt2MbL81TXZ1BTC--Scz7gzEd9vQmdI~33kYqeWjQbiQVWqhVyjk5-34GD7Y7rkOLQaZB6MXgMqMoWOyfRKDyTbykg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RADIOPROTECTIVE_EFFECT_OF_NATURAL_MODULATORS_OF_BIOLOGICAL_RESPONSE_N_ACETYL_L_CYSTEINE_AND_α_LIPOIC_ACID_PREVENTIVELY_ADMINISTERED_IN_AN_EXPERIMENTAL_LYMPHOCYTE_CELLULAR_MODEL","translated_slug":"","page_count":72,"language":"ru","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117919597,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919597/thumbnails/1.jpg","file_name":"899.pdf","download_url":"https://www.academia.edu/attachments/117919597/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RAD.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919597/899-libre.pdf?1725352501=\u0026response-content-disposition=attachment%3B+filename%3DCOMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RAD.pdf\u0026Expires=1732831889\u0026Signature=Nq1~45bYHmf7ukBGTxfKiMZlGFD4H9Q7daZ4hML1ERJJ6M-a~-HPF7JYF6WWVSebeNk7chnQGEeKL6ef6GcuyS13QaDwHOckZY8AwwoWnYD2T2AmRDyiAY8eJGWDzHXEoxEJrUd~7lm8rgYywFreIOh2fRdQ9Yz4lPAh5r~~NgJVdDXEgeXAQLS8LmUlwmeztw531OxkrBc03T0zMQnGqc0sWasDRoG1r0swJLn-UZCwGLToZEyfu0F6EzNqVt2MbL81TXZ1BTC--Scz7gzEd9vQmdI~33kYqeWjQbiQVWqhVyjk5-34GD7Y7rkOLQaZB6MXgMqMoWOyfRKDyTbykg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":10032,"name":"Radiation Protection","url":"https://www.academia.edu/Documents/in/Radiation_Protection"},{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":233757,"name":"Radioprotector","url":"https://www.academia.edu/Documents/in/Radioprotector"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123503454"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123503454/Research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis"><img alt="Research paper thumbnail of Research of the potential radioprotective activity of trimethyl glycine and nacetyllcysteine with quantitative analysis" class="work-thumbnail" src="https://attachments.academia-assets.com/117919396/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123503454/Research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis">Research of the potential radioprotective activity of trimethyl glycine and nacetyllcysteine with quantitative analysis</a></div><div class="wp-workCard_item"><span>Medical & Clinical Research</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract The irradiation exposure could affect the cellular genome and specifically target genes,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract<br />The irradiation exposure could affect the cellular genome and specifically target genes, such as TP53 gene. The TP53 gene is known<br />as a “guardian of the genome” and is a tumor suppressor gene. Its role is to keep the cell of malignant transformation. After ionizing<br />radiation exposure, the TP53 could mutate and the cell could continue to active proliferation (tumor cellular transformation). It has<br />been noticed that different type of substances could have radioprotective effect and to protect the cell of malignant transformation,<br />apoptosis, genome injuries or necrosis. Some of the natural metabolites that are proven antioxidants, show significant ability of radiation<br />protection of the cells.<br />The aim of that study is to analyze the possible radioprotection ability of two origin metabolites (amino acids)–trimethyl glycine (betaine)<br />and N-acetyl-L-cysteine, applied together and in combination, first before irradiation (preventive treatment) and then 2 hours after<br />irradiation (as a therapeutic agents). The research work is done as invitro analysis to peripheral blood cell cultures.<br />Conclusion: The conclusion of the study is that both amino acids showed good radiation protection activity after in-vitro performed<br />analysis. The most significant results showed the combination of both natural metabolit</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c03573f3c962453daeb73f702a729956" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117919396,"asset_id":123503454,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117919396/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123503454"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123503454"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123503454; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123503454]").text(description); $(".js-view-count[data-work-id=123503454]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123503454; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123503454']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123503454, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c03573f3c962453daeb73f702a729956" } } $('.js-work-strip[data-work-id=123503454]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123503454,"title":"Research of the potential radioprotective activity of trimethyl glycine and nacetyllcysteine with quantitative analysis","translated_title":"","metadata":{"doi":"10.33140/MCR.09.04.04","issue":"4","volume":"9","abstract":"Abstract\nThe irradiation exposure could affect the cellular genome and specifically target genes, such as TP53 gene. The TP53 gene is known\nas a “guardian of the genome” and is a tumor suppressor gene. Its role is to keep the cell of malignant transformation. After ionizing\nradiation exposure, the TP53 could mutate and the cell could continue to active proliferation (tumor cellular transformation). It has\nbeen noticed that different type of substances could have radioprotective effect and to protect the cell of malignant transformation,\napoptosis, genome injuries or necrosis. Some of the natural metabolites that are proven antioxidants, show significant ability of radiation\nprotection of the cells.\nThe aim of that study is to analyze the possible radioprotection ability of two origin metabolites (amino acids)–trimethyl glycine (betaine)\nand N-acetyl-L-cysteine, applied together and in combination, first before irradiation (preventive treatment) and then 2 hours after\nirradiation (as a therapeutic agents). The research work is done as invitro analysis to peripheral blood cell cultures.\nConclusion: The conclusion of the study is that both amino acids showed good radiation protection activity after in-vitro performed\nanalysis. The most significant results showed the combination of both natural metabolit","publisher":"Medical \u0026 Clinical Research ISSN: 2577 - 8005","page_numbers":"1-5","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Medical \u0026 Clinical Research"},"translated_abstract":"Abstract\nThe irradiation exposure could affect the cellular genome and specifically target genes, such as TP53 gene. The TP53 gene is known\nas a “guardian of the genome” and is a tumor suppressor gene. Its role is to keep the cell of malignant transformation. After ionizing\nradiation exposure, the TP53 could mutate and the cell could continue to active proliferation (tumor cellular transformation). It has\nbeen noticed that different type of substances could have radioprotective effect and to protect the cell of malignant transformation,\napoptosis, genome injuries or necrosis. Some of the natural metabolites that are proven antioxidants, show significant ability of radiation\nprotection of the cells.\nThe aim of that study is to analyze the possible radioprotection ability of two origin metabolites (amino acids)–trimethyl glycine (betaine)\nand N-acetyl-L-cysteine, applied together and in combination, first before irradiation (preventive treatment) and then 2 hours after\nirradiation (as a therapeutic agents). The research work is done as invitro analysis to peripheral blood cell cultures.\nConclusion: The conclusion of the study is that both amino acids showed good radiation protection activity after in-vitro performed\nanalysis. The most significant results showed the combination of both natural metabolit","internal_url":"https://www.academia.edu/123503454/Research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis","translated_internal_url":"","created_at":"2024-09-03T00:27:52.635-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":117919396,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919396/thumbnails/1.jpg","file_name":"research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis_.pdf","download_url":"https://www.academia.edu/attachments/117919396/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Research_of_the_potential_radioprotectiv.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919396/research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis_-libre.pdf?1725352507=\u0026response-content-disposition=attachment%3B+filename%3DResearch_of_the_potential_radioprotectiv.pdf\u0026Expires=1732831889\u0026Signature=IgjfYbtSgrbZslu5moVANbQ-Pa34eNXVujFfSjC-QnSyoEyPR2HdKwXeaAlLAxeAIOdomAIPnK6U-3cohXH72SUZi22YU-5~MLOfmY~E0GFFrAdtlALnDaRfGCb0W9QGJgUbdVz7ggd~WWYN7Jmq3BHXen-UQam1glkRt-e0gYjHhorbF11wJwao5AKqVuzM939yH6zOj69BRzwL86yZUzOXfZl3IkQ-SobZKedyag~8neSvEuBYQga95w-5t-JNgFePeaHIFz8c5TfBfIaeZqopsFodMXepfT4-hFr6J2mfW~Hq99~MhXhraSooRR2KonRp9~okZ3H7rOOMg1hmrw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117919396,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919396/thumbnails/1.jpg","file_name":"research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis_.pdf","download_url":"https://www.academia.edu/attachments/117919396/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Research_of_the_potential_radioprotectiv.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919396/research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis_-libre.pdf?1725352507=\u0026response-content-disposition=attachment%3B+filename%3DResearch_of_the_potential_radioprotectiv.pdf\u0026Expires=1732831889\u0026Signature=IgjfYbtSgrbZslu5moVANbQ-Pa34eNXVujFfSjC-QnSyoEyPR2HdKwXeaAlLAxeAIOdomAIPnK6U-3cohXH72SUZi22YU-5~MLOfmY~E0GFFrAdtlALnDaRfGCb0W9QGJgUbdVz7ggd~WWYN7Jmq3BHXen-UQam1glkRt-e0gYjHhorbF11wJwao5AKqVuzM939yH6zOj69BRzwL86yZUzOXfZl3IkQ-SobZKedyag~8neSvEuBYQga95w-5t-JNgFePeaHIFz8c5TfBfIaeZqopsFodMXepfT4-hFr6J2mfW~Hq99~MhXhraSooRR2KonRp9~okZ3H7rOOMg1hmrw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":10032,"name":"Radiation Protection","url":"https://www.academia.edu/Documents/in/Radiation_Protection"},{"id":18325,"name":"Radiobiology of Ionizing Radiation","url":"https://www.academia.edu/Documents/in/Radiobiology_of_Ionizing_Radiation"},{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":132620,"name":"Radiobiology","url":"https://www.academia.edu/Documents/in/Radiobiology"},{"id":233757,"name":"Radioprotector","url":"https://www.academia.edu/Documents/in/Radioprotector"},{"id":233824,"name":"Radioprotection","url":"https://www.academia.edu/Documents/in/Radioprotection"},{"id":317806,"name":"Biodosimetry","url":"https://www.academia.edu/Documents/in/Biodosimetry"},{"id":801884,"name":"Cytogenetic Biodosimetry","url":"https://www.academia.edu/Documents/in/Cytogenetic_Biodosimetry"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123503107"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123503107/Qualitatively_determine_the_possible_radioprotective_ability_of_the_amino_acids_N_acetyl_L_cysteine_and_N_N_N_trimethyl_glycine_betaine"><img alt="Research paper thumbnail of Qualitatively determine the possible radioprotective ability of the amino acids N-acetyl-L-cysteine and N,N,N-trimethyl glycine (betaine" class="work-thumbnail" src="https://attachments.academia-assets.com/117919208/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123503107/Qualitatively_determine_the_possible_radioprotective_ability_of_the_amino_acids_N_acetyl_L_cysteine_and_N_N_N_trimethyl_glycine_betaine">Qualitatively determine the possible radioprotective ability of the amino acids N-acetyl-L-cysteine and N,N,N-trimethyl glycine (betaine</a></div><div class="wp-workCard_item"><span>World scientific news </span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ionizing radiation exposure induces severe cellular injuries, such as single-and double-strand br...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ionizing radiation exposure induces severe cellular injuries, such as single-and double-strand breaks, base lost, base's changes, chromosomal aberrations, etc. Double strand breaks are the most significant and dangerous for the cell. As a result of action of the ionizing radiation the level of free radicals (more specific reactive oxygen species) increases many times and leads to severe cellular injuries. Oxidative stress has appeared. Double strand breaks could lead to formation of genomic instability that could become a stable change and to mutate the cell. High doses of ionizing radiation led to destroying of the whole DNA-genome and to formation of DNA-fragmentation. The aim of the currents study is to qualitatively determine the possible radioprotective ability of the amino acids Nacetyl-L-cysteine and N,N,N-trimethyl glycine (betaine). DNA-ladders method has been used for conformation of the radioprotective activity of analyzed two amino acids (betaine and N-acetyl-Lcysteine). The obtained result of the conducted research showed a possible high potential for radioprotective ability of both metabolites and set the stage for additional studies in an experimental cell model to confirm or reject the result.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="34fcf462cbd3ccaf619bb6cfe508f21d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117919208,"asset_id":123503107,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117919208/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123503107"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123503107"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123503107; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123503107]").text(description); $(".js-view-count[data-work-id=123503107]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123503107; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123503107']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123503107, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "34fcf462cbd3ccaf619bb6cfe508f21d" } } $('.js-work-strip[data-work-id=123503107]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123503107,"title":"Qualitatively determine the possible radioprotective ability of the amino acids N-acetyl-L-cysteine and N,N,N-trimethyl glycine (betaine","translated_title":"","metadata":{"abstract":"Ionizing radiation exposure induces severe cellular injuries, such as single-and double-strand breaks, base lost, base's changes, chromosomal aberrations, etc. Double strand breaks are the most significant and dangerous for the cell. 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High doses of ionizing radiation led to destroying of the whole DNA-genome and to formation of DNA-fragmentation. The aim of the currents study is to qualitatively determine the possible radioprotective ability of the amino acids Nacetyl-L-cysteine and N,N,N-trimethyl glycine (betaine). DNA-ladders method has been used for conformation of the radioprotective activity of analyzed two amino acids (betaine and N-acetyl-Lcysteine). The obtained result of the conducted research showed a possible high potential for radioprotective ability of both metabolites and set the stage for additional studies in an experimental cell model to confirm or reject the result.","internal_url":"https://www.academia.edu/123503107/Qualitatively_determine_the_possible_radioprotective_ability_of_the_amino_acids_N_acetyl_L_cysteine_and_N_N_N_trimethyl_glycine_betaine","translated_internal_url":"","created_at":"2024-09-03T00:14:38.814-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42319202,"work_id":123503107,"tagging_user_id":298664184,"tagged_user_id":298664184,"co_author_invite_id":8233017,"email":"g***a@gmail.com","affiliation":"Military Medical Academy","display_order":1,"name":"Galina Racheva","title":"Qualitatively determine the possible radioprotective ability of the amino acids N-acetyl-L-cysteine and N,N,N-trimethyl glycine (betaine"}],"downloadable_attachments":[{"id":117919208,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919208/thumbnails/1.jpg","file_name":"WSN_192_2024_149_156.pdf","download_url":"https://www.academia.edu/attachments/117919208/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Qualitatively_determine_the_possible_rad.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919208/WSN_192_2024_149_156-libre.pdf?1725348337=\u0026response-content-disposition=attachment%3B+filename%3DQualitatively_determine_the_possible_rad.pdf\u0026Expires=1732831889\u0026Signature=Pr5MjTHHOKIo1889esztJzZxpMo3EaUiwHajctuPD-vxADuHz7361OCmzshdfGEEUcoNCJ-t3R7DXAbnLJVXgYp4qSJlI63hhaGeHE5N~tDpIK12oJ70IbhSydTqCz3KRN3cR6hW-ZAVrMOKeI8bxlAn3-4Kj7Tp15GH3l20Fcci4C-fdm50iEYxkTQ4uoA29DI8A0Qy6~~5LO2V4HizUOF0hDUL8RQGcyxpvexI-fQGyddBVL2q7CQLjmiavn5xOdczfPrVdrjECMc066D-MMo~xYBmG5MI-1r5qWiAjuxwrjr~9nNnTKsLf5a1goe8Xrr2kAOmchJ-mWcqCTMwxw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Qualitatively_determine_the_possible_radioprotective_ability_of_the_amino_acids_N_acetyl_L_cysteine_and_N_N_N_trimethyl_glycine_betaine","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117919208,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919208/thumbnails/1.jpg","file_name":"WSN_192_2024_149_156.pdf","download_url":"https://www.academia.edu/attachments/117919208/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Qualitatively_determine_the_possible_rad.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919208/WSN_192_2024_149_156-libre.pdf?1725348337=\u0026response-content-disposition=attachment%3B+filename%3DQualitatively_determine_the_possible_rad.pdf\u0026Expires=1732831889\u0026Signature=Pr5MjTHHOKIo1889esztJzZxpMo3EaUiwHajctuPD-vxADuHz7361OCmzshdfGEEUcoNCJ-t3R7DXAbnLJVXgYp4qSJlI63hhaGeHE5N~tDpIK12oJ70IbhSydTqCz3KRN3cR6hW-ZAVrMOKeI8bxlAn3-4Kj7Tp15GH3l20Fcci4C-fdm50iEYxkTQ4uoA29DI8A0Qy6~~5LO2V4HizUOF0hDUL8RQGcyxpvexI-fQGyddBVL2q7CQLjmiavn5xOdczfPrVdrjECMc066D-MMo~xYBmG5MI-1r5qWiAjuxwrjr~9nNnTKsLf5a1goe8Xrr2kAOmchJ-mWcqCTMwxw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":10032,"name":"Radiation Protection","url":"https://www.academia.edu/Documents/in/Radiation_Protection"},{"id":18325,"name":"Radiobiology of Ionizing Radiation","url":"https://www.academia.edu/Documents/in/Radiobiology_of_Ionizing_Radiation"},{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":233757,"name":"Radioprotector","url":"https://www.academia.edu/Documents/in/Radioprotector"},{"id":801884,"name":"Cytogenetic Biodosimetry","url":"https://www.academia.edu/Documents/in/Cytogenetic_Biodosimetry"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123502985"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123502985/Amino_Acid_Betaine_Trimethyl_Glycine_As_A_Factor_Of_Recovery_Of_The_Hemopoietic_Syndrome_Induced_By_The_Ionizing_Radiation"><img alt="Research paper thumbnail of Amino Acid Betaine (Trimethyl Glycine) As A Factor Of Recovery Of The Hemopoietic Syndrome, Induced By The Ionizing Radiation" class="work-thumbnail" src="https://attachments.academia-assets.com/117919127/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123502985/Amino_Acid_Betaine_Trimethyl_Glycine_As_A_Factor_Of_Recovery_Of_The_Hemopoietic_Syndrome_Induced_By_The_Ionizing_Radiation">Amino Acid Betaine (Trimethyl Glycine) As A Factor Of Recovery Of The Hemopoietic Syndrome, Induced By The Ionizing Radiation</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0">Galina Racheva</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/IvanKindekov">Ivan Kindekov</a></span></div><div class="wp-workCard_item"><span>Overview of some of the current biodosimet ry methods for evaluation o f t he assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The radioprotection activity of different substances, such as cellular metabolites with antioxida...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The radioprotection activity of different substances, such as cellular metabolites with antioxidant activity to reduce the cellular damage induced by ionizing radiation has been studied for more than 50 years. Many research studies are focused on the radioprotective efficacy of naturally occurring antioxidants (natural metabolites), and how they might influence various endpoints of radiation damage. Aim: in the current study has been research the irradiation recovery and possible antioxidant activity after feeding the experimental animals with trimethyl glycine (betaine), as a food supplement. Materials and methods: in the current study were used experimental modal animals (white male mice c3h, weight 23 gr.) That were divided in four groups. Two of the groups were exposed to radiation from 137 cs with power 2,05 gy/min. The food supplement has been administrated to three of the experimental groups of animals, peroral, every day during 15 days before irradiation of those that are exposed. Lipid peroxidation levels in liver, spleen and testis were followed to all of the groups. Results: the research analysis gave significant results of decrease the levels of lipid peroxidation (in liver, spleen and testis), comparing the measurements in four different groups for every organcontrol group with irradiation without feeding, control group without irradiation with feeding, experimental group with irradiation and feeding. Conclusion: the researched amino acid has positive effect over survival rate in experimental animals. Administration of the amino acid shows decrease of the oxidative stress in the experimental group in comparison to control group with irradiation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f0f5dbead71ff0cfabefcf6694031dc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117919127,"asset_id":123502985,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117919127/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123502985"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123502985"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123502985; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123502985]").text(description); $(".js-view-count[data-work-id=123502985]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123502985; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123502985']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123502985, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f0f5dbead71ff0cfabefcf6694031dc" } } $('.js-work-strip[data-work-id=123502985]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123502985,"title":"Amino Acid Betaine (Trimethyl Glycine) As A Factor Of Recovery Of The Hemopoietic Syndrome, Induced By The Ionizing Radiation","translated_title":"","metadata":{"doi":"10.9790/0853-2302032326","issue":"2","volume":"23","abstract":"The radioprotection activity of different substances, such as cellular metabolites with antioxidant activity to reduce the cellular damage induced by ionizing radiation has been studied for more than 50 years. Many research studies are focused on the radioprotective efficacy of naturally occurring antioxidants (natural metabolites), and how they might influence various endpoints of radiation damage. Aim: in the current study has been research the irradiation recovery and possible antioxidant activity after feeding the experimental animals with trimethyl glycine (betaine), as a food supplement. Materials and methods: in the current study were used experimental modal animals (white male mice c3h, weight 23 gr.) That were divided in four groups. Two of the groups were exposed to radiation from 137 cs with power 2,05 gy/min. The food supplement has been administrated to three of the experimental groups of animals, peroral, every day during 15 days before irradiation of those that are exposed. Lipid peroxidation levels in liver, spleen and testis were followed to all of the groups. Results: the research analysis gave significant results of decrease the levels of lipid peroxidation (in liver, spleen and testis), comparing the measurements in four different groups for every organcontrol group with irradiation without feeding, control group without irradiation with feeding, experimental group with irradiation and feeding. Conclusion: the researched amino acid has positive effect over survival rate in experimental animals. Administration of the amino acid shows decrease of the oxidative stress in the experimental group in comparison to control group with irradiation.","publisher":"IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)","page_numbers":"23-26","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Overview of some of the current biodosimet ry methods for evaluation o f t he assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria"},"translated_abstract":"The radioprotection activity of different substances, such as cellular metabolites with antioxidant activity to reduce the cellular damage induced by ionizing radiation has been studied for more than 50 years. Many research studies are focused on the radioprotective efficacy of naturally occurring antioxidants (natural metabolites), and how they might influence various endpoints of radiation damage. Aim: in the current study has been research the irradiation recovery and possible antioxidant activity after feeding the experimental animals with trimethyl glycine (betaine), as a food supplement. Materials and methods: in the current study were used experimental modal animals (white male mice c3h, weight 23 gr.) That were divided in four groups. Two of the groups were exposed to radiation from 137 cs with power 2,05 gy/min. The food supplement has been administrated to three of the experimental groups of animals, peroral, every day during 15 days before irradiation of those that are exposed. Lipid peroxidation levels in liver, spleen and testis were followed to all of the groups. Results: the research analysis gave significant results of decrease the levels of lipid peroxidation (in liver, spleen and testis), comparing the measurements in four different groups for every organcontrol group with irradiation without feeding, control group without irradiation with feeding, experimental group with irradiation and feeding. Conclusion: the researched amino acid has positive effect over survival rate in experimental animals. Administration of the amino acid shows decrease of the oxidative stress in the experimental group in comparison to control group with irradiation.","internal_url":"https://www.academia.edu/123502985/Amino_Acid_Betaine_Trimethyl_Glycine_As_A_Factor_Of_Recovery_Of_The_Hemopoietic_Syndrome_Induced_By_The_Ionizing_Radiation","translated_internal_url":"","created_at":"2024-09-03T00:09:44.611-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42319194,"work_id":123502985,"tagging_user_id":298664184,"tagged_user_id":300103645,"co_author_invite_id":null,"email":"i***v@gmail.com","display_order":1,"name":"Ivan Kindekov","title":"Amino Acid Betaine (Trimethyl Glycine) As A Factor Of Recovery Of The Hemopoietic Syndrome, Induced By The Ionizing Radiation"}],"downloadable_attachments":[{"id":117919127,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919127/thumbnails/1.jpg","file_name":"E2302032326.pdf","download_url":"https://www.academia.edu/attachments/117919127/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Amino_Acid_Betaine_Trimethyl_Glycine_As.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919127/E2302032326-libre.pdf?1725348361=\u0026response-content-disposition=attachment%3B+filename%3DAmino_Acid_Betaine_Trimethyl_Glycine_As.pdf\u0026Expires=1732831889\u0026Signature=goum~9JsPSmrly3LpvCYKrjqAncnD6PxdYXpR92kl5H~a21Mhj39JCwtRjxZYa88Wi8tUfBN0EZetCms8~vqkDMuVhU5zTlTZ4xwOBzbtU-MVVcJI1mGOf5GtUm-s~VO6luVShsEp3GGd8Pp74oSHstTjktDZsXNUDfdX0yJHS6199w57mprbUiIkncmtPFcIgro3~g1Huyftd6kqZZixcgg647HCMOU6R3W9g4ttuyfUSpw5jNIN2RbUvoJUXlCTaUxYMYDcme6JgAkg~IG1XZpcOJ5cjQDIqR1Th4uBWlqNZbIZQBNN94r5x8~1d5WO6hJtQ5dAQIRiT5HfBuEdg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Amino_Acid_Betaine_Trimethyl_Glycine_As_A_Factor_Of_Recovery_Of_The_Hemopoietic_Syndrome_Induced_By_The_Ionizing_Radiation","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117919127,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919127/thumbnails/1.jpg","file_name":"E2302032326.pdf","download_url":"https://www.academia.edu/attachments/117919127/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Amino_Acid_Betaine_Trimethyl_Glycine_As.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919127/E2302032326-libre.pdf?1725348361=\u0026response-content-disposition=attachment%3B+filename%3DAmino_Acid_Betaine_Trimethyl_Glycine_As.pdf\u0026Expires=1732831889\u0026Signature=goum~9JsPSmrly3LpvCYKrjqAncnD6PxdYXpR92kl5H~a21Mhj39JCwtRjxZYa88Wi8tUfBN0EZetCms8~vqkDMuVhU5zTlTZ4xwOBzbtU-MVVcJI1mGOf5GtUm-s~VO6luVShsEp3GGd8Pp74oSHstTjktDZsXNUDfdX0yJHS6199w57mprbUiIkncmtPFcIgro3~g1Huyftd6kqZZixcgg647HCMOU6R3W9g4ttuyfUSpw5jNIN2RbUvoJUXlCTaUxYMYDcme6JgAkg~IG1XZpcOJ5cjQDIqR1Th4uBWlqNZbIZQBNN94r5x8~1d5WO6hJtQ5dAQIRiT5HfBuEdg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":10032,"name":"Radiation Protection","url":"https://www.academia.edu/Documents/in/Radiation_Protection"},{"id":18325,"name":"Radiobiology of Ionizing Radiation","url":"https://www.academia.edu/Documents/in/Radiobiology_of_Ionizing_Radiation"},{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":317806,"name":"Biodosimetry","url":"https://www.academia.edu/Documents/in/Biodosimetry"}],"urls":[{"id":44435715,"url":"https://www.iosrjournals.org/iosr-jdms/pages/23(2)Series-3.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123502163"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123502163/Overview_of_some_of_the_current_biodosimetry_methods_for_evaluation_of_the_assessment_dose_after_ionizing_exposure_in_the_EU_laboratories_Applicable_biodosimetry_methods_in_Bulgaria"><img alt="Research paper thumbnail of Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria." class="work-thumbnail" src="https://attachments.academia-assets.com/117918562/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123502163/Overview_of_some_of_the_current_biodosimetry_methods_for_evaluation_of_the_assessment_dose_after_ionizing_exposure_in_the_EU_laboratories_Applicable_biodosimetry_methods_in_Bulgaria">Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria.</a></div><div class="wp-workCard_item"><span>International Journal of Computational Engineering Research (IJCER)</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The worldwide political situation determines, the EU radiobiologists to develop and improve bidos...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The worldwide political situation determines, the EU radiobiologists to develop and improve bidosimetry methods for analysis of the assessment dose in their own laboratories. For a short period of time every Radiobiology laboratory in the EU had to choose or improve applicable method of analysis, to develop working protocols and their own calibration curves for the applicable methods. The Scientific laboratory of Radiobiology and Radia tion protec tion,<br />Milit ary Medical Academy Sofia is responsible for biodosimetr y esti mation of the assessment<br />dose to the military structures in Bulgaria . Aim of the study: The aim of the current study is to analyze and compare some of the current biodosimetry methods, used in the European laboratories. Selection of a part of the analyzed methods for current use in one of the Bulgarian radiobiology laboratories; Materials and methods: comparison of the advantages and disadvantages of the most used radiobiology methods used in the EU radiobiology laboratories such as Dicentric chromosomal assay (DCA), cytokinesis-block micronucleus assay (CBMN), premature chromosome condensation assay (PCC) and fluorescence in situ hybridization (FISH) chromosomal analysis. Results: The detailed analysis and review of the applied European methods, give the priority to the golden standard method (DCA), as the most applicable, shorten and highly effective for the needs of S cientific laboratory of Radiobiology and Radia tio n<br />protec tion, Milit ary Medical Academy SofiaSofia. The advantages of the FISH technique show a good perspective and could be performed for biodosimetry in the laboratory. Conclusion: The biodosimetry assessment of the absorbed dose is a high skilled activity that involves team of professionals, working in the laboratory, correct selection of a few appropriate methods and preliminary optimization of the process. Take into consideration all described factors for our routine work use of DCA method is the first and optimal option. The FISH-technique presents many advantages that makes it a good additional option.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1ee3216a9143fea828efd9571cdd42ef" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117918562,"asset_id":123502163,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117918562/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123502163"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123502163"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123502163; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123502163]").text(description); $(".js-view-count[data-work-id=123502163]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123502163; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123502163']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123502163, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1ee3216a9143fea828efd9571cdd42ef" } } $('.js-work-strip[data-work-id=123502163]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123502163,"title":"Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria.","translated_title":"","metadata":{"issue":"6","volume":"13","abstract":"The worldwide political situation determines, the EU radiobiologists to develop and improve bidosimetry methods for analysis of the assessment dose in their own laboratories. For a short period of time every Radiobiology laboratory in the EU had to choose or improve applicable method of analysis, to develop working protocols and their own calibration curves for the applicable methods. The Scientific laboratory of Radiobiology and Radia tion protec tion,\nMilit ary Medical Academy Sofia is responsible for biodosimetr y esti mation of the assessment\ndose to the military structures in Bulgaria . Aim of the study: The aim of the current study is to analyze and compare some of the current biodosimetry methods, used in the European laboratories. Selection of a part of the analyzed methods for current use in one of the Bulgarian radiobiology laboratories; Materials and methods: comparison of the advantages and disadvantages of the most used radiobiology methods used in the EU radiobiology laboratories such as Dicentric chromosomal assay (DCA), cytokinesis-block micronucleus assay (CBMN), premature chromosome condensation assay (PCC) and fluorescence in situ hybridization (FISH) chromosomal analysis. Results: The detailed analysis and review of the applied European methods, give the priority to the golden standard method (DCA), as the most applicable, shorten and highly effective for the needs of S cientific laboratory of Radiobiology and Radia tio n\nprotec tion, Milit ary Medical Academy SofiaSofia. The advantages of the FISH technique show a good perspective and could be performed for biodosimetry in the laboratory. Conclusion: The biodosimetry assessment of the absorbed dose is a high skilled activity that involves team of professionals, working in the laboratory, correct selection of a few appropriate methods and preliminary optimization of the process. Take into consideration all described factors for our routine work use of DCA method is the first and optimal option. The FISH-technique presents many advantages that makes it a good additional option.","publisher":"International Journal of Computational Engineering Research (IJCER)","page_numbers":"31-35","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"International Journal of Computational Engineering Research (IJCER)"},"translated_abstract":"The worldwide political situation determines, the EU radiobiologists to develop and improve bidosimetry methods for analysis of the assessment dose in their own laboratories. For a short period of time every Radiobiology laboratory in the EU had to choose or improve applicable method of analysis, to develop working protocols and their own calibration curves for the applicable methods. The Scientific laboratory of Radiobiology and Radia tion protec tion,\nMilit ary Medical Academy Sofia is responsible for biodosimetr y esti mation of the assessment\ndose to the military structures in Bulgaria . Aim of the study: The aim of the current study is to analyze and compare some of the current biodosimetry methods, used in the European laboratories. Selection of a part of the analyzed methods for current use in one of the Bulgarian radiobiology laboratories; Materials and methods: comparison of the advantages and disadvantages of the most used radiobiology methods used in the EU radiobiology laboratories such as Dicentric chromosomal assay (DCA), cytokinesis-block micronucleus assay (CBMN), premature chromosome condensation assay (PCC) and fluorescence in situ hybridization (FISH) chromosomal analysis. Results: The detailed analysis and review of the applied European methods, give the priority to the golden standard method (DCA), as the most applicable, shorten and highly effective for the needs of S cientific laboratory of Radiobiology and Radia tio n\nprotec tion, Milit ary Medical Academy SofiaSofia. The advantages of the FISH technique show a good perspective and could be performed for biodosimetry in the laboratory. Conclusion: The biodosimetry assessment of the absorbed dose is a high skilled activity that involves team of professionals, working in the laboratory, correct selection of a few appropriate methods and preliminary optimization of the process. Take into consideration all described factors for our routine work use of DCA method is the first and optimal option. The FISH-technique presents many advantages that makes it a good additional option.","internal_url":"https://www.academia.edu/123502163/Overview_of_some_of_the_current_biodosimetry_methods_for_evaluation_of_the_assessment_dose_after_ionizing_exposure_in_the_EU_laboratories_Applicable_biodosimetry_methods_in_Bulgaria","translated_internal_url":"","created_at":"2024-09-02T23:37:45.472-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42318998,"work_id":123502163,"tagging_user_id":298664184,"tagged_user_id":298664184,"co_author_invite_id":8233017,"email":"g***a@gmail.com","affiliation":"Military Medical Academy","display_order":1,"name":"Galina Racheva","title":"Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria."},{"id":42318999,"work_id":123502163,"tagging_user_id":298664184,"tagged_user_id":300103645,"co_author_invite_id":null,"email":"i***v@gmail.com","display_order":2,"name":"Ivan Kindekov","title":"Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria."},{"id":42319000,"work_id":123502163,"tagging_user_id":298664184,"tagged_user_id":324569284,"co_author_invite_id":8233018,"email":"v***e@abv.bg","display_order":3,"name":"Todorova P","title":"Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria."}],"downloadable_attachments":[{"id":117918562,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117918562/thumbnails/1.jpg","file_name":"E13063235.pdf","download_url":"https://www.academia.edu/attachments/117918562/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Overview_of_some_of_the_current_biodosim.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117918562/E13063235-libre.pdf?1725348501=\u0026response-content-disposition=attachment%3B+filename%3DOverview_of_some_of_the_current_biodosim.pdf\u0026Expires=1732831889\u0026Signature=JTP4SebEigl-oZX5CaKg3g0Ur0vh-gelVWIUSqZaWTTvCur06mzaqw2oDEKJtn2Vl39eMR5MzgZFeAlp2l5yv0J6uXdjhFdFzljNQfXXiME9soINpbQKYaNNdIsQgpLA4oxADDH9pTOfjvPXml7zthaXY3nwx1bi2~n~9Roh6tZtnWICXB4lx8-WCBZCrIeB1mEqaLbe1zHsyVoIP5XkTt9MrsVVLnjR0bcRw08oUVIM3t~4MjH7WbFUX2zst29jaFnn5koRF~~afHwqvX8vSAo55F4L8Dfnve5k2JON~LcT8tvBNHZ0MlGedCXC9u1Sx~HqYg~ak7tgZ1-Z1zEORA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Overview_of_some_of_the_current_biodosimetry_methods_for_evaluation_of_the_assessment_dose_after_ionizing_exposure_in_the_EU_laboratories_Applicable_biodosimetry_methods_in_Bulgaria","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117918562,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117918562/thumbnails/1.jpg","file_name":"E13063235.pdf","download_url":"https://www.academia.edu/attachments/117918562/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Overview_of_some_of_the_current_biodosim.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117918562/E13063235-libre.pdf?1725348501=\u0026response-content-disposition=attachment%3B+filename%3DOverview_of_some_of_the_current_biodosim.pdf\u0026Expires=1732831889\u0026Signature=JTP4SebEigl-oZX5CaKg3g0Ur0vh-gelVWIUSqZaWTTvCur06mzaqw2oDEKJtn2Vl39eMR5MzgZFeAlp2l5yv0J6uXdjhFdFzljNQfXXiME9soINpbQKYaNNdIsQgpLA4oxADDH9pTOfjvPXml7zthaXY3nwx1bi2~n~9Roh6tZtnWICXB4lx8-WCBZCrIeB1mEqaLbe1zHsyVoIP5XkTt9MrsVVLnjR0bcRw08oUVIM3t~4MjH7WbFUX2zst29jaFnn5koRF~~afHwqvX8vSAo55F4L8Dfnve5k2JON~LcT8tvBNHZ0MlGedCXC9u1Sx~HqYg~ak7tgZ1-Z1zEORA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":10032,"name":"Radiation Protection","url":"https://www.academia.edu/Documents/in/Radiation_Protection"},{"id":18325,"name":"Radiobiology of Ionizing Radiation","url":"https://www.academia.edu/Documents/in/Radiobiology_of_Ionizing_Radiation"},{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":317806,"name":"Biodosimetry","url":"https://www.academia.edu/Documents/in/Biodosimetry"},{"id":801884,"name":"Cytogenetic Biodosimetry","url":"https://www.academia.edu/Documents/in/Cytogenetic_Biodosimetry"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123502125"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123502125/CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN_THE_ROUTINE_PRACTICE_EXAMPLES_OF_CHRONIC_MYELOID_LEUKEMIA"><img alt="Research paper thumbnail of CYTOGENETIC ANALYSIS OF HEMOBLASTOSES IN THE ROUTINE PRACTICE – EXAMPLES OF CHRONIC MYELOID LEUKEMIA" class="work-thumbnail" src="https://attachments.academia-assets.com/117918486/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123502125/CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN_THE_ROUTINE_PRACTICE_EXAMPLES_OF_CHRONIC_MYELOID_LEUKEMIA">CYTOGENETIC ANALYSIS OF HEMOBLASTOSES IN THE ROUTINE PRACTICE – EXAMPLES OF CHRONIC MYELOID LEUKEMIA</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0">Galina Racheva</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/TodorovaP1">Todorova P</a></span></div><div class="wp-workCard_item"><span>Military Medicine</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The peripheral blood consists two main compartments – blood plasma and form elements (blood cell...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The peripheral blood consists two main compartments <br />– blood plasma and form elements (blood cells). The <br />peripheral blood consists of two main components – <br />blood plasma and formed elements (blood cells). <br />Hemoblastoses develop when mutations occur in the <br />precursors of blood cells (progenitor cells). The progenitor <br />cells of the blood cells are mostly known as <br />stem cells. Stem cells have strong proliferative potential <br />and differentiate to two main blood branches – <br />myeloid (derived from myeloid progenitor cells) and <br />lymphoid (derived from lymphoid progenitor cells). <br />Under the action of various hematopoietic growth factors, <br />they differentiate into different cell types of their order [3]. Leukemias are a group of oncological diseases <br />characterized by an increase of the leukocytes <br />in the bone marrow and blood. Depending on the progression <br />of the disease, they are acute and chronic, <br />and according to the origin of the affected cells – myeloid <br />and lymphoid. Combinations between them give <br />four main categories [7]. The presence of certain chromosomal <br />markers underlies the WHO cancer classification. <br />Their observation is necessary to confirm or <br />reject a previously established diagnosis. The diagnosis <br />is made based on the clinical expertise, laboratory <br />tests and the observation of the specific cytogenetic <br />markers. <br />Chronic myeloid (myelogenous) leukemia is hemoblastosis, <br />which affect the cells of the myeloid branch. This <br />disease is characterized by the presence of a specific <br />chromosomal marker – Ph-chromosome. The presence <br />of the Ph-chromosome can be determined by <br />cytogenetic analysis. Cytogenetic analysis has a crucial <br />role in the diagnostic process and therapeutic response <br />in patients with hemoblastoses.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cb99c854cf685a1c3dcf7f50d88f33c4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117918486,"asset_id":123502125,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117918486/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123502125"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123502125"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123502125; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123502125]").text(description); $(".js-view-count[data-work-id=123502125]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123502125; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123502125']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123502125, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cb99c854cf685a1c3dcf7f50d88f33c4" } } $('.js-work-strip[data-work-id=123502125]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123502125,"title":"CYTOGENETIC ANALYSIS OF HEMOBLASTOSES\r\nIN THE ROUTINE PRACTICE – EXAMPLES OF\r\nCHRONIC MYELOID LEUKEMIA","translated_title":"","metadata":{"issue":"3","volume":"LXXV","abstract":"The peripheral blood consists two main compartments\r\n– blood plasma and form elements (blood cells). The\r\nperipheral blood consists of two main components –\r\nblood plasma and formed elements (blood cells).\r\nHemoblastoses develop when mutations occur in the\r\nprecursors of blood cells (progenitor cells). The progenitor\r\ncells of the blood cells are mostly known as\r\nstem cells. Stem cells have strong proliferative potential\r\nand differentiate to two main blood branches –\r\nmyeloid (derived from myeloid progenitor cells) and\r\nlymphoid (derived from lymphoid progenitor cells).\r\nUnder the action of various hematopoietic growth factors,\r\nthey differentiate into different cell types of their order [3]. Leukemias are a group of oncological diseases\r\ncharacterized by an increase of the leukocytes\r\nin the bone marrow and blood. Depending on the progression\r\nof the disease, they are acute and chronic,\r\nand according to the origin of the affected cells – myeloid\r\nand lymphoid. Combinations between them give\r\nfour main categories [7]. The presence of certain chromosomal\r\nmarkers underlies the WHO cancer classification.\r\nTheir observation is necessary to confirm or\r\nreject a previously established diagnosis. The diagnosis\r\nis made based on the clinical expertise, laboratory\r\ntests and the observation of the specific cytogenetic\r\nmarkers.\r\nChronic myeloid (myelogenous) leukemia is hemoblastosis,\r\nwhich affect the cells of the myeloid branch. This\r\ndisease is characterized by the presence of a specific\r\nchromosomal marker – Ph-chromosome. The presence\r\nof the Ph-chromosome can be determined by\r\ncytogenetic analysis. Cytogenetic analysis has a crucial\r\nrole in the diagnostic process and therapeutic response\r\nin patients with hemoblastoses.","publisher":"MILITARY MEDICINE OFFICIAL EDITION OF MILITARY MEDICAL ACADEMY AND BULGARIAN SCIENTIFIC SOCIETY OF MILITARY MEDICINE","page_numbers":"23-29","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Military Medicine"},"translated_abstract":"The peripheral blood consists two main compartments\r\n– blood plasma and form elements (blood cells). The\r\nperipheral blood consists of two main components –\r\nblood plasma and formed elements (blood cells).\r\nHemoblastoses develop when mutations occur in the\r\nprecursors of blood cells (progenitor cells). The progenitor\r\ncells of the blood cells are mostly known as\r\nstem cells. Stem cells have strong proliferative potential\r\nand differentiate to two main blood branches –\r\nmyeloid (derived from myeloid progenitor cells) and\r\nlymphoid (derived from lymphoid progenitor cells).\r\nUnder the action of various hematopoietic growth factors,\r\nthey differentiate into different cell types of their order [3]. Leukemias are a group of oncological diseases\r\ncharacterized by an increase of the leukocytes\r\nin the bone marrow and blood. Depending on the progression\r\nof the disease, they are acute and chronic,\r\nand according to the origin of the affected cells – myeloid\r\nand lymphoid. Combinations between them give\r\nfour main categories [7]. The presence of certain chromosomal\r\nmarkers underlies the WHO cancer classification.\r\nTheir observation is necessary to confirm or\r\nreject a previously established diagnosis. The diagnosis\r\nis made based on the clinical expertise, laboratory\r\ntests and the observation of the specific cytogenetic\r\nmarkers.\r\nChronic myeloid (myelogenous) leukemia is hemoblastosis,\r\nwhich affect the cells of the myeloid branch. This\r\ndisease is characterized by the presence of a specific\r\nchromosomal marker – Ph-chromosome. The presence\r\nof the Ph-chromosome can be determined by\r\ncytogenetic analysis. Cytogenetic analysis has a crucial\r\nrole in the diagnostic process and therapeutic response\r\nin patients with hemoblastoses.","internal_url":"https://www.academia.edu/123502125/CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN_THE_ROUTINE_PRACTICE_EXAMPLES_OF_CHRONIC_MYELOID_LEUKEMIA","translated_internal_url":"","created_at":"2024-09-02T23:35:48.112-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42319058,"work_id":123502125,"tagging_user_id":298664184,"tagged_user_id":300103645,"co_author_invite_id":null,"email":"i***v@gmail.com","display_order":1,"name":"Ivan Kindekov","title":"CYTOGENETIC ANALYSIS OF HEMOBLASTOSES\r\nIN THE ROUTINE PRACTICE – EXAMPLES OF\r\nCHRONIC MYELOID LEUKEMIA"},{"id":42319059,"work_id":123502125,"tagging_user_id":298664184,"tagged_user_id":324569284,"co_author_invite_id":8233018,"email":"v***e@abv.bg","display_order":2,"name":"Todorova P","title":"CYTOGENETIC ANALYSIS OF HEMOBLASTOSES\r\nIN THE ROUTINE PRACTICE – EXAMPLES OF\r\nCHRONIC MYELOID LEUKEMIA"}],"downloadable_attachments":[{"id":117918486,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117918486/thumbnails/1.jpg","file_name":"23_29.pdf","download_url":"https://www.academia.edu/attachments/117918486/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117918486/23_29-libre.pdf?1725348528=\u0026response-content-disposition=attachment%3B+filename%3DCYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN.pdf\u0026Expires=1732831889\u0026Signature=PP~OtQIEwFGf3SJ3xuJuh-Zz0ODFIsAz6rutm1sxGXV4d-Kqx4bd0NipDASgtpSL5NID8N3iDYiQvOLQDFHJR2VF1Tk8iUtVJom2Kzipp7nxT8tMOBD8LMvNqsexc~OGERCobqbRlRwiu69cJi-Uk0cNA7-tTgGMfOy3qbP5vofLeAdOfvyfJZC838cUv02-lps2KtlgtSisVHSXzeLDxI0Waou5~Jxz7ZatcyQ~w~9NPwrQ8ZFx2j0-rV-jH3z8AtRKHuMJ8BF1jmIqtpJWljIRwA~V1BXC31Z6qa-czlPSAmKrWzbeQbs7mi9y1StcFyPR-Jpj5cd4Iug2J0Lncw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN_THE_ROUTINE_PRACTICE_EXAMPLES_OF_CHRONIC_MYELOID_LEUKEMIA","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117918486,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117918486/thumbnails/1.jpg","file_name":"23_29.pdf","download_url":"https://www.academia.edu/attachments/117918486/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117918486/23_29-libre.pdf?1725348528=\u0026response-content-disposition=attachment%3B+filename%3DCYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN.pdf\u0026Expires=1732831889\u0026Signature=PP~OtQIEwFGf3SJ3xuJuh-Zz0ODFIsAz6rutm1sxGXV4d-Kqx4bd0NipDASgtpSL5NID8N3iDYiQvOLQDFHJR2VF1Tk8iUtVJom2Kzipp7nxT8tMOBD8LMvNqsexc~OGERCobqbRlRwiu69cJi-Uk0cNA7-tTgGMfOy3qbP5vofLeAdOfvyfJZC838cUv02-lps2KtlgtSisVHSXzeLDxI0Waou5~Jxz7ZatcyQ~w~9NPwrQ8ZFx2j0-rV-jH3z8AtRKHuMJ8BF1jmIqtpJWljIRwA~V1BXC31Z6qa-czlPSAmKrWzbeQbs7mi9y1StcFyPR-Jpj5cd4Iug2J0Lncw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":53424,"name":"Chronic Myeloid Leukaemia","url":"https://www.academia.edu/Documents/in/Chronic_Myeloid_Leukaemia"}],"urls":[{"id":44430882,"url":"https://www.vma.bg/%D0%92%D0%BE%D0%B5%D0%BD%D0%BD%D0%B0-%D0%9C%D0%B5%D0%B4%D0%B8%D1%86%D0%B8%D0%BD%D0%B0-2023.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="19966611" id="papers"><div class="js-work-strip profile--work_container" data-work-id="124124936"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124124936/Research_of_the_Potential_Radioprotective_Activity_of_Trimethyl_Glycine_and_N_Acetyl_L_Cysteine_with_Quantitative_Analysis_Using_Real_Time_Polymerase_Chain_Reaction_QRT_PCR_"><img alt="Research paper thumbnail of Research of the Potential Radioprotective Activity of Trimethyl Glycine and N-Acetyl-L-Cysteine with Quantitative Analysis Using Real-Time Polymerase Chain Reaction (QRT-PCR)" class="work-thumbnail" src="https://attachments.academia-assets.com/118405599/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124124936/Research_of_the_Potential_Radioprotective_Activity_of_Trimethyl_Glycine_and_N_Acetyl_L_Cysteine_with_Quantitative_Analysis_Using_Real_Time_Polymerase_Chain_Reaction_QRT_PCR_">Research of the Potential Radioprotective Activity of Trimethyl Glycine and N-Acetyl-L-Cysteine with Quantitative Analysis Using Real-Time Polymerase Chain Reaction (QRT-PCR)</a></div><div class="wp-workCard_item"><span>Medical & clinical research</span><span>, Apr 1, 2024</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="629e275c12eb0d4825981e1701464698" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118405599,"asset_id":124124936,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118405599/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124124936"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124124936"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124124936; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "629e275c12eb0d4825981e1701464698" } } $('.js-work-strip[data-work-id=124124936]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124124936,"title":"Research of the Potential Radioprotective Activity of Trimethyl Glycine and N-Acetyl-L-Cysteine with Quantitative Analysis Using Real-Time Polymerase Chain Reaction (QRT-PCR)","translated_title":"","metadata":{"grobid_abstract":"The irradiation exposure could affect the cellular genome and specifically target genes, such as TP53 gene. The TP53 gene is known as a \"guardian of the genome\" and is a tumor suppressor gene. Its role is to keep the cell of malignant transformation. After ionizing radiation exposure, the TP53 could mutate and the cell could continue to active proliferation (tumor cellular transformation). It has been noticed that different type of substances could have radioprotective effect and to protect the cell of malignant transformation, apoptosis, genome injuries or necrosis. Some of the natural metabolites that are proven antioxidants, show significant ability of radiation protection of the cells. The aim of that study is to analyze the possible radioprotection ability of two origin metabolites (amino acids)-trimethyl glycine (betaine) and N-acetyl-L-cysteine, applied together and in combination, first before irradiation (preventive treatment) and then 2 hours after irradiation (as a therapeutic agents). The research work is done as invitro analysis to peripheral blood cell cultures. Conclusion: The conclusion of the study is that both amino acids showed good radiation protection activity after in-vitro performed analysis. 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protection activity of two natural amino acids N-acetyl-L-cysteine and trimethylglycine</a></div><div class="wp-workCard_item"><span>Archives in Cancer Research</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="45cc8bbbf109a382456337a03e8d5af3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118405619,"asset_id":124124933,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118405619/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124124933"><a class="js-profile-work-strip-edit-button" 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src="https://attachments.academia-assets.com/117919757/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123503848/Different_aspects_of_the_assessment_observation_and_medical_treatment_of_the_acute_radiation_syndrome">Different aspects of the assessment, observation and medical treatment of the acute radiation syndrome</a></div><div class="wp-workCard_item"><span>BULGARIAN MEDICINE</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute radiation syndrome is a special medical condition that combines symptoms of four different ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute radiation syndrome is a special medical<br />condition that combines symptoms of four<br />different sub-syndromes combined or separately.<br />The assessment of the acute radiation<br />syndrome follow strictly defined protocol<br />approved by IAEA. The most important part of<br />the assessment is to calculate the absorbed<br />dose after the exposure and the type of the<br />irradiation such as whole-body or significant<br />partial body exposure to over limited dose (><br />1 Gy absorbed dose). The next step is the<br />medical treatment of the patient. The treatment<br />of the acute radition syndrome depends<br />on the patient condition, dose rate and the<br />type of irradiation. Patients who received a<br />high dose and whole body irradiation (> 1Gy<br />and < 10 Gy) are going to be triage to three<br />different groups: patients, who recover with<br />minimum interventions, those who require<br />aggressive supportive treatment such as<br />bone-marrow transplantation and those, who<br />will receive palliative care. The possibility of<br />local or systematic infection increased with the irradiation, because of the appeared damages<br />in the cutaneous and mucosal barriers<br />and immune system suppression. To prevent<br />the risk of infections in the medical treatment<br />scheme have to be included antibiotics, an<br />antiviral and antifungal drugs. The application<br />of the antimicrobial drugs follow three different<br />approaches depends on the medical condition<br />of the patient.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8b8fe696806d9029d3f81ec078723177" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117919757,"asset_id":123503848,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117919757/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123503848"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123503848"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123503848; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123503848]").text(description); $(".js-view-count[data-work-id=123503848]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123503848; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123503848']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123503848, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8b8fe696806d9029d3f81ec078723177" } } $('.js-work-strip[data-work-id=123503848]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123503848,"title":"Different aspects of the assessment, observation and medical treatment of the acute radiation syndrome","translated_title":"","metadata":{"abstract":"Acute radiation syndrome is a special medical\ncondition that combines symptoms of four\ndifferent sub-syndromes combined or separately.\nThe assessment of the acute radiation\nsyndrome follow strictly defined protocol\napproved by IAEA. The most important part of\nthe assessment is to calculate the absorbed\ndose after the exposure and the type of the\nirradiation such as whole-body or significant\npartial body exposure to over limited dose (\u003e\n1 Gy absorbed dose). The next step is the\nmedical treatment of the patient. The treatment\nof the acute radition syndrome depends\non the patient condition, dose rate and the\ntype of irradiation. Patients who received a\nhigh dose and whole body irradiation (\u003e 1Gy\nand \u003c 10 Gy) are going to be triage to three\ndifferent groups: patients, who recover with\nminimum interventions, those who require\naggressive supportive treatment such as\nbone-marrow transplantation and those, who\nwill receive palliative care. The possibility of\nlocal or systematic infection increased with the irradiation, because of the appeared damages\nin the cutaneous and mucosal barriers\nand immune system suppression. To prevent\nthe risk of infections in the medical treatment\nscheme have to be included antibiotics, an\nantiviral and antifungal drugs. The application\nof the antimicrobial drugs follow three different\napproaches depends on the medical condition\nof the patient.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"BULGARIAN MEDICINE"},"translated_abstract":"Acute radiation syndrome is a special medical\ncondition that combines symptoms of four\ndifferent sub-syndromes combined or separately.\nThe assessment of the acute radiation\nsyndrome follow strictly defined protocol\napproved by IAEA. The most important part of\nthe assessment is to calculate the absorbed\ndose after the exposure and the type of the\nirradiation such as whole-body or significant\npartial body exposure to over limited dose (\u003e\n1 Gy absorbed dose). The next step is the\nmedical treatment of the patient. The treatment\nof the acute radition syndrome depends\non the patient condition, dose rate and the\ntype of irradiation. Patients who received a\nhigh dose and whole body irradiation (\u003e 1Gy\nand \u003c 10 Gy) are going to be triage to three\ndifferent groups: patients, who recover with\nminimum interventions, those who require\naggressive supportive treatment such as\nbone-marrow transplantation and those, who\nwill receive palliative care. The possibility of\nlocal or systematic infection increased with the irradiation, because of the appeared damages\nin the cutaneous and mucosal barriers\nand immune system suppression. To prevent\nthe risk of infections in the medical treatment\nscheme have to be included antibiotics, an\nantiviral and antifungal drugs. The application\nof the antimicrobial drugs follow three different\napproaches depends on the medical condition\nof the patient.","internal_url":"https://www.academia.edu/123503848/Different_aspects_of_the_assessment_observation_and_medical_treatment_of_the_acute_radiation_syndrome","translated_internal_url":"","created_at":"2024-09-03T00:43:08.345-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42319310,"work_id":123503848,"tagging_user_id":298664184,"tagged_user_id":300103645,"co_author_invite_id":null,"email":"i***v@gmail.com","display_order":1,"name":"Ivan Kindekov","title":"Different aspects of the assessment, observation and medical treatment of the acute radiation syndrome"},{"id":42325158,"work_id":123503848,"tagging_user_id":298664184,"tagged_user_id":298664184,"co_author_invite_id":8233017,"email":"g***a@gmail.com","affiliation":"Military Medical Academy","display_order":1073741824,"name":"Galina Racheva","title":"Different aspects of the assessment, observation and medical treatment of the acute radiation syndrome"}],"downloadable_attachments":[{"id":117919757,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919757/thumbnails/1.jpg","file_name":"spisanie_balgarska_medicina_br_01_2020.pdf","download_url":"https://www.academia.edu/attachments/117919757/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Different_aspects_of_the_assessment_obse.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919757/spisanie_balgarska_medicina_br_01_2020-libre.pdf?1725352819=\u0026response-content-disposition=attachment%3B+filename%3DDifferent_aspects_of_the_assessment_obse.pdf\u0026Expires=1732831889\u0026Signature=Ls3Nt9J-ARrMFZiDegX40jNYiOnCVbYPFbAbnlDAiOo7TxPZ0zTn872nnEzwAVOsYEq7gTp2~en3CHVJe2gsTZE9UML5tVyDxGFD0ptilfyS57mW68lGK3mm6mLhnx4tLQ5sDFobhPNsAsRNf7l~lo4XvidyRSohmnStbwSS0WjrwaQo~I-dZWY1YOW21oyF5iysvqu9Ch4aENKvaeCdW0Kr3fnuXN9uQu4c4irtHZigjks-rn5bFvjDnWXxzBJqu808W0FuphmnokQdJPS6SbUItXs6MRNzAvcIYuDiAztQeb23P2~psgN9PzbCE3RWrUpQ16CmiLcBbvzRyuCBXA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Different_aspects_of_the_assessment_observation_and_medical_treatment_of_the_acute_radiation_syndrome","translated_slug":"","page_count":60,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117919757,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919757/thumbnails/1.jpg","file_name":"spisanie_balgarska_medicina_br_01_2020.pdf","download_url":"https://www.academia.edu/attachments/117919757/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Different_aspects_of_the_assessment_obse.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919757/spisanie_balgarska_medicina_br_01_2020-libre.pdf?1725352819=\u0026response-content-disposition=attachment%3B+filename%3DDifferent_aspects_of_the_assessment_obse.pdf\u0026Expires=1732831889\u0026Signature=Ls3Nt9J-ARrMFZiDegX40jNYiOnCVbYPFbAbnlDAiOo7TxPZ0zTn872nnEzwAVOsYEq7gTp2~en3CHVJe2gsTZE9UML5tVyDxGFD0ptilfyS57mW68lGK3mm6mLhnx4tLQ5sDFobhPNsAsRNf7l~lo4XvidyRSohmnStbwSS0WjrwaQo~I-dZWY1YOW21oyF5iysvqu9Ch4aENKvaeCdW0Kr3fnuXN9uQu4c4irtHZigjks-rn5bFvjDnWXxzBJqu808W0FuphmnokQdJPS6SbUItXs6MRNzAvcIYuDiAztQeb23P2~psgN9PzbCE3RWrUpQ16CmiLcBbvzRyuCBXA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology"},{"id":18325,"name":"Radiobiology of Ionizing Radiation","url":"https://www.academia.edu/Documents/in/Radiobiology_of_Ionizing_Radiation"},{"id":132620,"name":"Radiobiology","url":"https://www.academia.edu/Documents/in/Radiobiology"}],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123503662"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123503662/COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RADIOPROTECTIVE_EFFECT_OF_NATURAL_MODULATORS_OF_BIOLOGICAL_RESPONSE_N_ACETYL_L_CYSTEINE_AND_%CE%B1_LIPOIC_ACID_PREVENTIVELY_ADMINISTERED_IN_AN_EXPERIMENTAL_LYMPHOCYTE_CELLULAR_MODEL"><img alt="Research paper thumbnail of COMPARATIVE CYTOGENETIC STUDY OF THE RADIOPROTECTIVE EFFECT OF NATURAL MODULATORS OF BIOLOGICAL RESPONSE N-ACETYL-L-CYSTEINE AND α-LIPOIC ACID PREVENTIVELY ADMINISTERED IN AN EXPERIMENTAL LYMPHOCYTE CELLULAR MODEL" class="work-thumbnail" src="https://attachments.academia-assets.com/117919597/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123503662/COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RADIOPROTECTIVE_EFFECT_OF_NATURAL_MODULATORS_OF_BIOLOGICAL_RESPONSE_N_ACETYL_L_CYSTEINE_AND_%CE%B1_LIPOIC_ACID_PREVENTIVELY_ADMINISTERED_IN_AN_EXPERIMENTAL_LYMPHOCYTE_CELLULAR_MODEL">COMPARATIVE CYTOGENETIC STUDY OF THE RADIOPROTECTIVE EFFECT OF NATURAL MODULATORS OF BIOLOGICAL RESPONSE N-ACETYL-L-CYSTEINE AND α-LIPOIC ACID PREVENTIVELY ADMINISTERED IN AN EXPERIMENTAL LYMPHOCYTE CELLULAR MODEL</a></div><div class="wp-workCard_item"><span>MILITARY MEDICINE OFFICIAL EDITION OF MILITARY MEDICAL ACADEMY AND BULGARIAN SCIENTIFIC SOCIETY OF MILITARY MEDICINE</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Most of the cellular damages and the development of radiation- induced cellular pathology are ind...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Most of the cellular damages and the development of radiation-<br />induced cellular pathology are indirect effects caused by free<br />radicals. Oxidative damage is the result of the reactive oxygen<br />species generated by ionizing radiation. This perspective is at<br />the heart of research and development of tools that can provide<br />a longer window of protection against lethal damage and other<br />effects resulting from low-dose irradiation in professional groups,<br />diagnostic and therapeutic procedures. A major focus in radiobiology<br />is the study of substances capable of trapping free radicals<br />or preventing their expression, with minimal or no toxic effects.<br />Many natural antioxidants, such as N-Acetyl-L-cysteine and α-Lipoic<br />acid, have antimutagenic properties and have radioprotective<br />potential. They act as modulators of the biological response<br />(immunomodulators) and can redirect the cell to apoptosis in the<br />event of neoplastic transformation. The aim of the study was to<br />compare the potential radioprotective ability of the two native immunomodulators,<br />administered before irradiation, separately and<br />in combination, with a 1Gy absorbed dose in an experimental human<br />lymphocyte cell model. Biodosimetric method of cytogenetic<br />analysis of metaphase chromosomes were used to determine<br />the presence of radiation-induced dicentric and circular chromosomes.<br />Survey results showed radioprotective effect. Reducing<br />the number of chromosomal aberrations correlates with the radioprotective<br />ability of the two native antioxidants to reduce the risk<br />of radiation damage.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="209a731538ad8fec98f9a3d0acd76c4c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117919597,"asset_id":123503662,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117919597/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123503662"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123503662"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123503662; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123503662]").text(description); $(".js-view-count[data-work-id=123503662]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123503662; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123503662']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123503662, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "209a731538ad8fec98f9a3d0acd76c4c" } } $('.js-work-strip[data-work-id=123503662]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123503662,"title":"COMPARATIVE CYTOGENETIC STUDY OF THE RADIOPROTECTIVE EFFECT OF NATURAL MODULATORS OF BIOLOGICAL RESPONSE N-ACETYL-L-CYSTEINE AND α-LIPOIC ACID PREVENTIVELY ADMINISTERED IN AN EXPERIMENTAL LYMPHOCYTE CELLULAR MODEL","translated_title":"","metadata":{"abstract":"Most of the cellular damages and the development of radiation-\ninduced cellular pathology are indirect effects caused by free\nradicals. Oxidative damage is the result of the reactive oxygen\nspecies generated by ionizing radiation. This perspective is at\nthe heart of research and development of tools that can provide\na longer window of protection against lethal damage and other\neffects resulting from low-dose irradiation in professional groups,\ndiagnostic and therapeutic procedures. A major focus in radiobiology\nis the study of substances capable of trapping free radicals\nor preventing their expression, with minimal or no toxic effects.\nMany natural antioxidants, such as N-Acetyl-L-cysteine and α-Lipoic\nacid, have antimutagenic properties and have radioprotective\npotential. They act as modulators of the biological response\n(immunomodulators) and can redirect the cell to apoptosis in the\nevent of neoplastic transformation. The aim of the study was to\ncompare the potential radioprotective ability of the two native immunomodulators,\nadministered before irradiation, separately and\nin combination, with a 1Gy absorbed dose in an experimental human\nlymphocyte cell model. Biodosimetric method of cytogenetic\nanalysis of metaphase chromosomes were used to determine\nthe presence of radiation-induced dicentric and circular chromosomes.\nSurvey results showed radioprotective effect. Reducing\nthe number of chromosomal aberrations correlates with the radioprotective\nability of the two native antioxidants to reduce the risk\nof radiation damage.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"MILITARY MEDICINE OFFICIAL EDITION OF MILITARY MEDICAL ACADEMY AND BULGARIAN SCIENTIFIC SOCIETY OF MILITARY MEDICINE"},"translated_abstract":"Most of the cellular damages and the development of radiation-\ninduced cellular pathology are indirect effects caused by free\nradicals. Oxidative damage is the result of the reactive oxygen\nspecies generated by ionizing radiation. This perspective is at\nthe heart of research and development of tools that can provide\na longer window of protection against lethal damage and other\neffects resulting from low-dose irradiation in professional groups,\ndiagnostic and therapeutic procedures. A major focus in radiobiology\nis the study of substances capable of trapping free radicals\nor preventing their expression, with minimal or no toxic effects.\nMany natural antioxidants, such as N-Acetyl-L-cysteine and α-Lipoic\nacid, have antimutagenic properties and have radioprotective\npotential. They act as modulators of the biological response\n(immunomodulators) and can redirect the cell to apoptosis in the\nevent of neoplastic transformation. The aim of the study was to\ncompare the potential radioprotective ability of the two native immunomodulators,\nadministered before irradiation, separately and\nin combination, with a 1Gy absorbed dose in an experimental human\nlymphocyte cell model. Biodosimetric method of cytogenetic\nanalysis of metaphase chromosomes were used to determine\nthe presence of radiation-induced dicentric and circular chromosomes.\nSurvey results showed radioprotective effect. Reducing\nthe number of chromosomal aberrations correlates with the radioprotective\nability of the two native antioxidants to reduce the risk\nof radiation damage.","internal_url":"https://www.academia.edu/123503662/COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RADIOPROTECTIVE_EFFECT_OF_NATURAL_MODULATORS_OF_BIOLOGICAL_RESPONSE_N_ACETYL_L_CYSTEINE_AND_%CE%B1_LIPOIC_ACID_PREVENTIVELY_ADMINISTERED_IN_AN_EXPERIMENTAL_LYMPHOCYTE_CELLULAR_MODEL","translated_internal_url":"","created_at":"2024-09-03T00:35:14.077-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":117919597,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919597/thumbnails/1.jpg","file_name":"899.pdf","download_url":"https://www.academia.edu/attachments/117919597/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RAD.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919597/899-libre.pdf?1725352501=\u0026response-content-disposition=attachment%3B+filename%3DCOMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RAD.pdf\u0026Expires=1732831889\u0026Signature=Nq1~45bYHmf7ukBGTxfKiMZlGFD4H9Q7daZ4hML1ERJJ6M-a~-HPF7JYF6WWVSebeNk7chnQGEeKL6ef6GcuyS13QaDwHOckZY8AwwoWnYD2T2AmRDyiAY8eJGWDzHXEoxEJrUd~7lm8rgYywFreIOh2fRdQ9Yz4lPAh5r~~NgJVdDXEgeXAQLS8LmUlwmeztw531OxkrBc03T0zMQnGqc0sWasDRoG1r0swJLn-UZCwGLToZEyfu0F6EzNqVt2MbL81TXZ1BTC--Scz7gzEd9vQmdI~33kYqeWjQbiQVWqhVyjk5-34GD7Y7rkOLQaZB6MXgMqMoWOyfRKDyTbykg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RADIOPROTECTIVE_EFFECT_OF_NATURAL_MODULATORS_OF_BIOLOGICAL_RESPONSE_N_ACETYL_L_CYSTEINE_AND_α_LIPOIC_ACID_PREVENTIVELY_ADMINISTERED_IN_AN_EXPERIMENTAL_LYMPHOCYTE_CELLULAR_MODEL","translated_slug":"","page_count":72,"language":"ru","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117919597,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919597/thumbnails/1.jpg","file_name":"899.pdf","download_url":"https://www.academia.edu/attachments/117919597/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"COMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RAD.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919597/899-libre.pdf?1725352501=\u0026response-content-disposition=attachment%3B+filename%3DCOMPARATIVE_CYTOGENETIC_STUDY_OF_THE_RAD.pdf\u0026Expires=1732831889\u0026Signature=Nq1~45bYHmf7ukBGTxfKiMZlGFD4H9Q7daZ4hML1ERJJ6M-a~-HPF7JYF6WWVSebeNk7chnQGEeKL6ef6GcuyS13QaDwHOckZY8AwwoWnYD2T2AmRDyiAY8eJGWDzHXEoxEJrUd~7lm8rgYywFreIOh2fRdQ9Yz4lPAh5r~~NgJVdDXEgeXAQLS8LmUlwmeztw531OxkrBc03T0zMQnGqc0sWasDRoG1r0swJLn-UZCwGLToZEyfu0F6EzNqVt2MbL81TXZ1BTC--Scz7gzEd9vQmdI~33kYqeWjQbiQVWqhVyjk5-34GD7Y7rkOLQaZB6MXgMqMoWOyfRKDyTbykg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":10032,"name":"Radiation Protection","url":"https://www.academia.edu/Documents/in/Radiation_Protection"},{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":233757,"name":"Radioprotector","url":"https://www.academia.edu/Documents/in/Radioprotector"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123503454"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123503454/Research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis"><img alt="Research paper thumbnail of Research of the potential radioprotective activity of trimethyl glycine and nacetyllcysteine with quantitative analysis" class="work-thumbnail" src="https://attachments.academia-assets.com/117919396/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123503454/Research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis">Research of the potential radioprotective activity of trimethyl glycine and nacetyllcysteine with quantitative analysis</a></div><div class="wp-workCard_item"><span>Medical & Clinical Research</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract The irradiation exposure could affect the cellular genome and specifically target genes,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract<br />The irradiation exposure could affect the cellular genome and specifically target genes, such as TP53 gene. The TP53 gene is known<br />as a “guardian of the genome” and is a tumor suppressor gene. Its role is to keep the cell of malignant transformation. After ionizing<br />radiation exposure, the TP53 could mutate and the cell could continue to active proliferation (tumor cellular transformation). It has<br />been noticed that different type of substances could have radioprotective effect and to protect the cell of malignant transformation,<br />apoptosis, genome injuries or necrosis. Some of the natural metabolites that are proven antioxidants, show significant ability of radiation<br />protection of the cells.<br />The aim of that study is to analyze the possible radioprotection ability of two origin metabolites (amino acids)–trimethyl glycine (betaine)<br />and N-acetyl-L-cysteine, applied together and in combination, first before irradiation (preventive treatment) and then 2 hours after<br />irradiation (as a therapeutic agents). The research work is done as invitro analysis to peripheral blood cell cultures.<br />Conclusion: The conclusion of the study is that both amino acids showed good radiation protection activity after in-vitro performed<br />analysis. The most significant results showed the combination of both natural metabolit</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c03573f3c962453daeb73f702a729956" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117919396,"asset_id":123503454,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117919396/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123503454"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123503454"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123503454; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123503454]").text(description); $(".js-view-count[data-work-id=123503454]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123503454; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123503454']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123503454, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c03573f3c962453daeb73f702a729956" } } $('.js-work-strip[data-work-id=123503454]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123503454,"title":"Research of the potential radioprotective activity of trimethyl glycine and nacetyllcysteine with quantitative analysis","translated_title":"","metadata":{"doi":"10.33140/MCR.09.04.04","issue":"4","volume":"9","abstract":"Abstract\nThe irradiation exposure could affect the cellular genome and specifically target genes, such as TP53 gene. The TP53 gene is known\nas a “guardian of the genome” and is a tumor suppressor gene. Its role is to keep the cell of malignant transformation. After ionizing\nradiation exposure, the TP53 could mutate and the cell could continue to active proliferation (tumor cellular transformation). It has\nbeen noticed that different type of substances could have radioprotective effect and to protect the cell of malignant transformation,\napoptosis, genome injuries or necrosis. Some of the natural metabolites that are proven antioxidants, show significant ability of radiation\nprotection of the cells.\nThe aim of that study is to analyze the possible radioprotection ability of two origin metabolites (amino acids)–trimethyl glycine (betaine)\nand N-acetyl-L-cysteine, applied together and in combination, first before irradiation (preventive treatment) and then 2 hours after\nirradiation (as a therapeutic agents). The research work is done as invitro analysis to peripheral blood cell cultures.\nConclusion: The conclusion of the study is that both amino acids showed good radiation protection activity after in-vitro performed\nanalysis. The most significant results showed the combination of both natural metabolit","publisher":"Medical \u0026 Clinical Research ISSN: 2577 - 8005","page_numbers":"1-5","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Medical \u0026 Clinical Research"},"translated_abstract":"Abstract\nThe irradiation exposure could affect the cellular genome and specifically target genes, such as TP53 gene. The TP53 gene is known\nas a “guardian of the genome” and is a tumor suppressor gene. Its role is to keep the cell of malignant transformation. After ionizing\nradiation exposure, the TP53 could mutate and the cell could continue to active proliferation (tumor cellular transformation). It has\nbeen noticed that different type of substances could have radioprotective effect and to protect the cell of malignant transformation,\napoptosis, genome injuries or necrosis. Some of the natural metabolites that are proven antioxidants, show significant ability of radiation\nprotection of the cells.\nThe aim of that study is to analyze the possible radioprotection ability of two origin metabolites (amino acids)–trimethyl glycine (betaine)\nand N-acetyl-L-cysteine, applied together and in combination, first before irradiation (preventive treatment) and then 2 hours after\nirradiation (as a therapeutic agents). The research work is done as invitro analysis to peripheral blood cell cultures.\nConclusion: The conclusion of the study is that both amino acids showed good radiation protection activity after in-vitro performed\nanalysis. The most significant results showed the combination of both natural metabolit","internal_url":"https://www.academia.edu/123503454/Research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis","translated_internal_url":"","created_at":"2024-09-03T00:27:52.635-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":117919396,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919396/thumbnails/1.jpg","file_name":"research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis_.pdf","download_url":"https://www.academia.edu/attachments/117919396/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Research_of_the_potential_radioprotectiv.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919396/research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis_-libre.pdf?1725352507=\u0026response-content-disposition=attachment%3B+filename%3DResearch_of_the_potential_radioprotectiv.pdf\u0026Expires=1732831889\u0026Signature=IgjfYbtSgrbZslu5moVANbQ-Pa34eNXVujFfSjC-QnSyoEyPR2HdKwXeaAlLAxeAIOdomAIPnK6U-3cohXH72SUZi22YU-5~MLOfmY~E0GFFrAdtlALnDaRfGCb0W9QGJgUbdVz7ggd~WWYN7Jmq3BHXen-UQam1glkRt-e0gYjHhorbF11wJwao5AKqVuzM939yH6zOj69BRzwL86yZUzOXfZl3IkQ-SobZKedyag~8neSvEuBYQga95w-5t-JNgFePeaHIFz8c5TfBfIaeZqopsFodMXepfT4-hFr6J2mfW~Hq99~MhXhraSooRR2KonRp9~okZ3H7rOOMg1hmrw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117919396,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919396/thumbnails/1.jpg","file_name":"research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis_.pdf","download_url":"https://www.academia.edu/attachments/117919396/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Research_of_the_potential_radioprotectiv.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919396/research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis_-libre.pdf?1725352507=\u0026response-content-disposition=attachment%3B+filename%3DResearch_of_the_potential_radioprotectiv.pdf\u0026Expires=1732831889\u0026Signature=IgjfYbtSgrbZslu5moVANbQ-Pa34eNXVujFfSjC-QnSyoEyPR2HdKwXeaAlLAxeAIOdomAIPnK6U-3cohXH72SUZi22YU-5~MLOfmY~E0GFFrAdtlALnDaRfGCb0W9QGJgUbdVz7ggd~WWYN7Jmq3BHXen-UQam1glkRt-e0gYjHhorbF11wJwao5AKqVuzM939yH6zOj69BRzwL86yZUzOXfZl3IkQ-SobZKedyag~8neSvEuBYQga95w-5t-JNgFePeaHIFz8c5TfBfIaeZqopsFodMXepfT4-hFr6J2mfW~Hq99~MhXhraSooRR2KonRp9~okZ3H7rOOMg1hmrw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":10032,"name":"Radiation Protection","url":"https://www.academia.edu/Documents/in/Radiation_Protection"},{"id":18325,"name":"Radiobiology of Ionizing Radiation","url":"https://www.academia.edu/Documents/in/Radiobiology_of_Ionizing_Radiation"},{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":132620,"name":"Radiobiology","url":"https://www.academia.edu/Documents/in/Radiobiology"},{"id":233757,"name":"Radioprotector","url":"https://www.academia.edu/Documents/in/Radioprotector"},{"id":233824,"name":"Radioprotection","url":"https://www.academia.edu/Documents/in/Radioprotection"},{"id":317806,"name":"Biodosimetry","url":"https://www.academia.edu/Documents/in/Biodosimetry"},{"id":801884,"name":"Cytogenetic Biodosimetry","url":"https://www.academia.edu/Documents/in/Cytogenetic_Biodosimetry"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123503107"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123503107/Qualitatively_determine_the_possible_radioprotective_ability_of_the_amino_acids_N_acetyl_L_cysteine_and_N_N_N_trimethyl_glycine_betaine"><img alt="Research paper thumbnail of Qualitatively determine the possible radioprotective ability of the amino acids N-acetyl-L-cysteine and N,N,N-trimethyl glycine (betaine" class="work-thumbnail" src="https://attachments.academia-assets.com/117919208/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123503107/Qualitatively_determine_the_possible_radioprotective_ability_of_the_amino_acids_N_acetyl_L_cysteine_and_N_N_N_trimethyl_glycine_betaine">Qualitatively determine the possible radioprotective ability of the amino acids N-acetyl-L-cysteine and N,N,N-trimethyl glycine (betaine</a></div><div class="wp-workCard_item"><span>World scientific news </span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ionizing radiation exposure induces severe cellular injuries, such as single-and double-strand br...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ionizing radiation exposure induces severe cellular injuries, such as single-and double-strand breaks, base lost, base's changes, chromosomal aberrations, etc. Double strand breaks are the most significant and dangerous for the cell. As a result of action of the ionizing radiation the level of free radicals (more specific reactive oxygen species) increases many times and leads to severe cellular injuries. Oxidative stress has appeared. Double strand breaks could lead to formation of genomic instability that could become a stable change and to mutate the cell. High doses of ionizing radiation led to destroying of the whole DNA-genome and to formation of DNA-fragmentation. The aim of the currents study is to qualitatively determine the possible radioprotective ability of the amino acids Nacetyl-L-cysteine and N,N,N-trimethyl glycine (betaine). DNA-ladders method has been used for conformation of the radioprotective activity of analyzed two amino acids (betaine and N-acetyl-Lcysteine). The obtained result of the conducted research showed a possible high potential for radioprotective ability of both metabolites and set the stage for additional studies in an experimental cell model to confirm or reject the result.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="34fcf462cbd3ccaf619bb6cfe508f21d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117919208,"asset_id":123503107,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117919208/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123503107"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123503107"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123503107; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123503107]").text(description); $(".js-view-count[data-work-id=123503107]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123503107; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123503107']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123503107, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "34fcf462cbd3ccaf619bb6cfe508f21d" } } $('.js-work-strip[data-work-id=123503107]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123503107,"title":"Qualitatively determine the possible radioprotective ability of the amino acids N-acetyl-L-cysteine and N,N,N-trimethyl glycine (betaine","translated_title":"","metadata":{"abstract":"Ionizing radiation exposure induces severe cellular injuries, such as single-and double-strand breaks, base lost, base's changes, chromosomal aberrations, etc. Double strand breaks are the most significant and dangerous for the cell. As a result of action of the ionizing radiation the level of free radicals (more specific reactive oxygen species) increases many times and leads to severe cellular injuries. Oxidative stress has appeared. Double strand breaks could lead to formation of genomic instability that could become a stable change and to mutate the cell. High doses of ionizing radiation led to destroying of the whole DNA-genome and to formation of DNA-fragmentation. The aim of the currents study is to qualitatively determine the possible radioprotective ability of the amino acids Nacetyl-L-cysteine and N,N,N-trimethyl glycine (betaine). DNA-ladders method has been used for conformation of the radioprotective activity of analyzed two amino acids (betaine and N-acetyl-Lcysteine). The obtained result of the conducted research showed a possible high potential for radioprotective ability of both metabolites and set the stage for additional studies in an experimental cell model to confirm or reject the result.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"World scientific news "},"translated_abstract":"Ionizing radiation exposure induces severe cellular injuries, such as single-and double-strand breaks, base lost, base's changes, chromosomal aberrations, etc. Double strand breaks are the most significant and dangerous for the cell. As a result of action of the ionizing radiation the level of free radicals (more specific reactive oxygen species) increases many times and leads to severe cellular injuries. Oxidative stress has appeared. Double strand breaks could lead to formation of genomic instability that could become a stable change and to mutate the cell. High doses of ionizing radiation led to destroying of the whole DNA-genome and to formation of DNA-fragmentation. The aim of the currents study is to qualitatively determine the possible radioprotective ability of the amino acids Nacetyl-L-cysteine and N,N,N-trimethyl glycine (betaine). DNA-ladders method has been used for conformation of the radioprotective activity of analyzed two amino acids (betaine and N-acetyl-Lcysteine). The obtained result of the conducted research showed a possible high potential for radioprotective ability of both metabolites and set the stage for additional studies in an experimental cell model to confirm or reject the result.","internal_url":"https://www.academia.edu/123503107/Qualitatively_determine_the_possible_radioprotective_ability_of_the_amino_acids_N_acetyl_L_cysteine_and_N_N_N_trimethyl_glycine_betaine","translated_internal_url":"","created_at":"2024-09-03T00:14:38.814-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42319202,"work_id":123503107,"tagging_user_id":298664184,"tagged_user_id":298664184,"co_author_invite_id":8233017,"email":"g***a@gmail.com","affiliation":"Military Medical Academy","display_order":1,"name":"Galina Racheva","title":"Qualitatively determine the possible radioprotective ability of the amino acids N-acetyl-L-cysteine and N,N,N-trimethyl glycine (betaine"}],"downloadable_attachments":[{"id":117919208,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919208/thumbnails/1.jpg","file_name":"WSN_192_2024_149_156.pdf","download_url":"https://www.academia.edu/attachments/117919208/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Qualitatively_determine_the_possible_rad.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919208/WSN_192_2024_149_156-libre.pdf?1725348337=\u0026response-content-disposition=attachment%3B+filename%3DQualitatively_determine_the_possible_rad.pdf\u0026Expires=1732831889\u0026Signature=Pr5MjTHHOKIo1889esztJzZxpMo3EaUiwHajctuPD-vxADuHz7361OCmzshdfGEEUcoNCJ-t3R7DXAbnLJVXgYp4qSJlI63hhaGeHE5N~tDpIK12oJ70IbhSydTqCz3KRN3cR6hW-ZAVrMOKeI8bxlAn3-4Kj7Tp15GH3l20Fcci4C-fdm50iEYxkTQ4uoA29DI8A0Qy6~~5LO2V4HizUOF0hDUL8RQGcyxpvexI-fQGyddBVL2q7CQLjmiavn5xOdczfPrVdrjECMc066D-MMo~xYBmG5MI-1r5qWiAjuxwrjr~9nNnTKsLf5a1goe8Xrr2kAOmchJ-mWcqCTMwxw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Qualitatively_determine_the_possible_radioprotective_ability_of_the_amino_acids_N_acetyl_L_cysteine_and_N_N_N_trimethyl_glycine_betaine","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117919208,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919208/thumbnails/1.jpg","file_name":"WSN_192_2024_149_156.pdf","download_url":"https://www.academia.edu/attachments/117919208/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Qualitatively_determine_the_possible_rad.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919208/WSN_192_2024_149_156-libre.pdf?1725348337=\u0026response-content-disposition=attachment%3B+filename%3DQualitatively_determine_the_possible_rad.pdf\u0026Expires=1732831889\u0026Signature=Pr5MjTHHOKIo1889esztJzZxpMo3EaUiwHajctuPD-vxADuHz7361OCmzshdfGEEUcoNCJ-t3R7DXAbnLJVXgYp4qSJlI63hhaGeHE5N~tDpIK12oJ70IbhSydTqCz3KRN3cR6hW-ZAVrMOKeI8bxlAn3-4Kj7Tp15GH3l20Fcci4C-fdm50iEYxkTQ4uoA29DI8A0Qy6~~5LO2V4HizUOF0hDUL8RQGcyxpvexI-fQGyddBVL2q7CQLjmiavn5xOdczfPrVdrjECMc066D-MMo~xYBmG5MI-1r5qWiAjuxwrjr~9nNnTKsLf5a1goe8Xrr2kAOmchJ-mWcqCTMwxw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":10032,"name":"Radiation Protection","url":"https://www.academia.edu/Documents/in/Radiation_Protection"},{"id":18325,"name":"Radiobiology of Ionizing Radiation","url":"https://www.academia.edu/Documents/in/Radiobiology_of_Ionizing_Radiation"},{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":233757,"name":"Radioprotector","url":"https://www.academia.edu/Documents/in/Radioprotector"},{"id":801884,"name":"Cytogenetic Biodosimetry","url":"https://www.academia.edu/Documents/in/Cytogenetic_Biodosimetry"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123502985"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123502985/Amino_Acid_Betaine_Trimethyl_Glycine_As_A_Factor_Of_Recovery_Of_The_Hemopoietic_Syndrome_Induced_By_The_Ionizing_Radiation"><img alt="Research paper thumbnail of Amino Acid Betaine (Trimethyl Glycine) As A Factor Of Recovery Of The Hemopoietic Syndrome, Induced By The Ionizing Radiation" class="work-thumbnail" src="https://attachments.academia-assets.com/117919127/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123502985/Amino_Acid_Betaine_Trimethyl_Glycine_As_A_Factor_Of_Recovery_Of_The_Hemopoietic_Syndrome_Induced_By_The_Ionizing_Radiation">Amino Acid Betaine (Trimethyl Glycine) As A Factor Of Recovery Of The Hemopoietic Syndrome, Induced By The Ionizing Radiation</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0">Galina Racheva</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/IvanKindekov">Ivan Kindekov</a></span></div><div class="wp-workCard_item"><span>Overview of some of the current biodosimet ry methods for evaluation o f t he assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The radioprotection activity of different substances, such as cellular metabolites with antioxida...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The radioprotection activity of different substances, such as cellular metabolites with antioxidant activity to reduce the cellular damage induced by ionizing radiation has been studied for more than 50 years. Many research studies are focused on the radioprotective efficacy of naturally occurring antioxidants (natural metabolites), and how they might influence various endpoints of radiation damage. Aim: in the current study has been research the irradiation recovery and possible antioxidant activity after feeding the experimental animals with trimethyl glycine (betaine), as a food supplement. Materials and methods: in the current study were used experimental modal animals (white male mice c3h, weight 23 gr.) That were divided in four groups. Two of the groups were exposed to radiation from 137 cs with power 2,05 gy/min. The food supplement has been administrated to three of the experimental groups of animals, peroral, every day during 15 days before irradiation of those that are exposed. Lipid peroxidation levels in liver, spleen and testis were followed to all of the groups. Results: the research analysis gave significant results of decrease the levels of lipid peroxidation (in liver, spleen and testis), comparing the measurements in four different groups for every organcontrol group with irradiation without feeding, control group without irradiation with feeding, experimental group with irradiation and feeding. Conclusion: the researched amino acid has positive effect over survival rate in experimental animals. Administration of the amino acid shows decrease of the oxidative stress in the experimental group in comparison to control group with irradiation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f0f5dbead71ff0cfabefcf6694031dc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117919127,"asset_id":123502985,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117919127/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123502985"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123502985"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123502985; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123502985]").text(description); $(".js-view-count[data-work-id=123502985]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123502985; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123502985']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123502985, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f0f5dbead71ff0cfabefcf6694031dc" } } $('.js-work-strip[data-work-id=123502985]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123502985,"title":"Amino Acid Betaine (Trimethyl Glycine) As A Factor Of Recovery Of The Hemopoietic Syndrome, Induced By The Ionizing Radiation","translated_title":"","metadata":{"doi":"10.9790/0853-2302032326","issue":"2","volume":"23","abstract":"The radioprotection activity of different substances, such as cellular metabolites with antioxidant activity to reduce the cellular damage induced by ionizing radiation has been studied for more than 50 years. Many research studies are focused on the radioprotective efficacy of naturally occurring antioxidants (natural metabolites), and how they might influence various endpoints of radiation damage. Aim: in the current study has been research the irradiation recovery and possible antioxidant activity after feeding the experimental animals with trimethyl glycine (betaine), as a food supplement. Materials and methods: in the current study were used experimental modal animals (white male mice c3h, weight 23 gr.) That were divided in four groups. Two of the groups were exposed to radiation from 137 cs with power 2,05 gy/min. The food supplement has been administrated to three of the experimental groups of animals, peroral, every day during 15 days before irradiation of those that are exposed. Lipid peroxidation levels in liver, spleen and testis were followed to all of the groups. Results: the research analysis gave significant results of decrease the levels of lipid peroxidation (in liver, spleen and testis), comparing the measurements in four different groups for every organcontrol group with irradiation without feeding, control group without irradiation with feeding, experimental group with irradiation and feeding. Conclusion: the researched amino acid has positive effect over survival rate in experimental animals. Administration of the amino acid shows decrease of the oxidative stress in the experimental group in comparison to control group with irradiation.","publisher":"IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)","page_numbers":"23-26","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Overview of some of the current biodosimet ry methods for evaluation o f t he assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria"},"translated_abstract":"The radioprotection activity of different substances, such as cellular metabolites with antioxidant activity to reduce the cellular damage induced by ionizing radiation has been studied for more than 50 years. Many research studies are focused on the radioprotective efficacy of naturally occurring antioxidants (natural metabolites), and how they might influence various endpoints of radiation damage. Aim: in the current study has been research the irradiation recovery and possible antioxidant activity after feeding the experimental animals with trimethyl glycine (betaine), as a food supplement. Materials and methods: in the current study were used experimental modal animals (white male mice c3h, weight 23 gr.) That were divided in four groups. Two of the groups were exposed to radiation from 137 cs with power 2,05 gy/min. The food supplement has been administrated to three of the experimental groups of animals, peroral, every day during 15 days before irradiation of those that are exposed. Lipid peroxidation levels in liver, spleen and testis were followed to all of the groups. Results: the research analysis gave significant results of decrease the levels of lipid peroxidation (in liver, spleen and testis), comparing the measurements in four different groups for every organcontrol group with irradiation without feeding, control group without irradiation with feeding, experimental group with irradiation and feeding. Conclusion: the researched amino acid has positive effect over survival rate in experimental animals. Administration of the amino acid shows decrease of the oxidative stress in the experimental group in comparison to control group with irradiation.","internal_url":"https://www.academia.edu/123502985/Amino_Acid_Betaine_Trimethyl_Glycine_As_A_Factor_Of_Recovery_Of_The_Hemopoietic_Syndrome_Induced_By_The_Ionizing_Radiation","translated_internal_url":"","created_at":"2024-09-03T00:09:44.611-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42319194,"work_id":123502985,"tagging_user_id":298664184,"tagged_user_id":300103645,"co_author_invite_id":null,"email":"i***v@gmail.com","display_order":1,"name":"Ivan Kindekov","title":"Amino Acid Betaine (Trimethyl Glycine) As A Factor Of Recovery Of The Hemopoietic Syndrome, Induced By The Ionizing Radiation"}],"downloadable_attachments":[{"id":117919127,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919127/thumbnails/1.jpg","file_name":"E2302032326.pdf","download_url":"https://www.academia.edu/attachments/117919127/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Amino_Acid_Betaine_Trimethyl_Glycine_As.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919127/E2302032326-libre.pdf?1725348361=\u0026response-content-disposition=attachment%3B+filename%3DAmino_Acid_Betaine_Trimethyl_Glycine_As.pdf\u0026Expires=1732831889\u0026Signature=goum~9JsPSmrly3LpvCYKrjqAncnD6PxdYXpR92kl5H~a21Mhj39JCwtRjxZYa88Wi8tUfBN0EZetCms8~vqkDMuVhU5zTlTZ4xwOBzbtU-MVVcJI1mGOf5GtUm-s~VO6luVShsEp3GGd8Pp74oSHstTjktDZsXNUDfdX0yJHS6199w57mprbUiIkncmtPFcIgro3~g1Huyftd6kqZZixcgg647HCMOU6R3W9g4ttuyfUSpw5jNIN2RbUvoJUXlCTaUxYMYDcme6JgAkg~IG1XZpcOJ5cjQDIqR1Th4uBWlqNZbIZQBNN94r5x8~1d5WO6hJtQ5dAQIRiT5HfBuEdg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Amino_Acid_Betaine_Trimethyl_Glycine_As_A_Factor_Of_Recovery_Of_The_Hemopoietic_Syndrome_Induced_By_The_Ionizing_Radiation","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117919127,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117919127/thumbnails/1.jpg","file_name":"E2302032326.pdf","download_url":"https://www.academia.edu/attachments/117919127/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Amino_Acid_Betaine_Trimethyl_Glycine_As.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117919127/E2302032326-libre.pdf?1725348361=\u0026response-content-disposition=attachment%3B+filename%3DAmino_Acid_Betaine_Trimethyl_Glycine_As.pdf\u0026Expires=1732831889\u0026Signature=goum~9JsPSmrly3LpvCYKrjqAncnD6PxdYXpR92kl5H~a21Mhj39JCwtRjxZYa88Wi8tUfBN0EZetCms8~vqkDMuVhU5zTlTZ4xwOBzbtU-MVVcJI1mGOf5GtUm-s~VO6luVShsEp3GGd8Pp74oSHstTjktDZsXNUDfdX0yJHS6199w57mprbUiIkncmtPFcIgro3~g1Huyftd6kqZZixcgg647HCMOU6R3W9g4ttuyfUSpw5jNIN2RbUvoJUXlCTaUxYMYDcme6JgAkg~IG1XZpcOJ5cjQDIqR1Th4uBWlqNZbIZQBNN94r5x8~1d5WO6hJtQ5dAQIRiT5HfBuEdg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":10032,"name":"Radiation Protection","url":"https://www.academia.edu/Documents/in/Radiation_Protection"},{"id":18325,"name":"Radiobiology of Ionizing Radiation","url":"https://www.academia.edu/Documents/in/Radiobiology_of_Ionizing_Radiation"},{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":317806,"name":"Biodosimetry","url":"https://www.academia.edu/Documents/in/Biodosimetry"}],"urls":[{"id":44435715,"url":"https://www.iosrjournals.org/iosr-jdms/pages/23(2)Series-3.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123502163"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123502163/Overview_of_some_of_the_current_biodosimetry_methods_for_evaluation_of_the_assessment_dose_after_ionizing_exposure_in_the_EU_laboratories_Applicable_biodosimetry_methods_in_Bulgaria"><img alt="Research paper thumbnail of Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria." class="work-thumbnail" src="https://attachments.academia-assets.com/117918562/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123502163/Overview_of_some_of_the_current_biodosimetry_methods_for_evaluation_of_the_assessment_dose_after_ionizing_exposure_in_the_EU_laboratories_Applicable_biodosimetry_methods_in_Bulgaria">Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria.</a></div><div class="wp-workCard_item"><span>International Journal of Computational Engineering Research (IJCER)</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The worldwide political situation determines, the EU radiobiologists to develop and improve bidos...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The worldwide political situation determines, the EU radiobiologists to develop and improve bidosimetry methods for analysis of the assessment dose in their own laboratories. For a short period of time every Radiobiology laboratory in the EU had to choose or improve applicable method of analysis, to develop working protocols and their own calibration curves for the applicable methods. The Scientific laboratory of Radiobiology and Radia tion protec tion,<br />Milit ary Medical Academy Sofia is responsible for biodosimetr y esti mation of the assessment<br />dose to the military structures in Bulgaria . Aim of the study: The aim of the current study is to analyze and compare some of the current biodosimetry methods, used in the European laboratories. Selection of a part of the analyzed methods for current use in one of the Bulgarian radiobiology laboratories; Materials and methods: comparison of the advantages and disadvantages of the most used radiobiology methods used in the EU radiobiology laboratories such as Dicentric chromosomal assay (DCA), cytokinesis-block micronucleus assay (CBMN), premature chromosome condensation assay (PCC) and fluorescence in situ hybridization (FISH) chromosomal analysis. Results: The detailed analysis and review of the applied European methods, give the priority to the golden standard method (DCA), as the most applicable, shorten and highly effective for the needs of S cientific laboratory of Radiobiology and Radia tio n<br />protec tion, Milit ary Medical Academy SofiaSofia. The advantages of the FISH technique show a good perspective and could be performed for biodosimetry in the laboratory. Conclusion: The biodosimetry assessment of the absorbed dose is a high skilled activity that involves team of professionals, working in the laboratory, correct selection of a few appropriate methods and preliminary optimization of the process. Take into consideration all described factors for our routine work use of DCA method is the first and optimal option. The FISH-technique presents many advantages that makes it a good additional option.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1ee3216a9143fea828efd9571cdd42ef" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117918562,"asset_id":123502163,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117918562/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123502163"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123502163"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123502163; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123502163]").text(description); $(".js-view-count[data-work-id=123502163]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123502163; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123502163']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123502163, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1ee3216a9143fea828efd9571cdd42ef" } } $('.js-work-strip[data-work-id=123502163]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123502163,"title":"Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria.","translated_title":"","metadata":{"issue":"6","volume":"13","abstract":"The worldwide political situation determines, the EU radiobiologists to develop and improve bidosimetry methods for analysis of the assessment dose in their own laboratories. For a short period of time every Radiobiology laboratory in the EU had to choose or improve applicable method of analysis, to develop working protocols and their own calibration curves for the applicable methods. The Scientific laboratory of Radiobiology and Radia tion protec tion,\nMilit ary Medical Academy Sofia is responsible for biodosimetr y esti mation of the assessment\ndose to the military structures in Bulgaria . Aim of the study: The aim of the current study is to analyze and compare some of the current biodosimetry methods, used in the European laboratories. Selection of a part of the analyzed methods for current use in one of the Bulgarian radiobiology laboratories; Materials and methods: comparison of the advantages and disadvantages of the most used radiobiology methods used in the EU radiobiology laboratories such as Dicentric chromosomal assay (DCA), cytokinesis-block micronucleus assay (CBMN), premature chromosome condensation assay (PCC) and fluorescence in situ hybridization (FISH) chromosomal analysis. Results: The detailed analysis and review of the applied European methods, give the priority to the golden standard method (DCA), as the most applicable, shorten and highly effective for the needs of S cientific laboratory of Radiobiology and Radia tio n\nprotec tion, Milit ary Medical Academy SofiaSofia. The advantages of the FISH technique show a good perspective and could be performed for biodosimetry in the laboratory. Conclusion: The biodosimetry assessment of the absorbed dose is a high skilled activity that involves team of professionals, working in the laboratory, correct selection of a few appropriate methods and preliminary optimization of the process. Take into consideration all described factors for our routine work use of DCA method is the first and optimal option. The FISH-technique presents many advantages that makes it a good additional option.","publisher":"International Journal of Computational Engineering Research (IJCER)","page_numbers":"31-35","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"International Journal of Computational Engineering Research (IJCER)"},"translated_abstract":"The worldwide political situation determines, the EU radiobiologists to develop and improve bidosimetry methods for analysis of the assessment dose in their own laboratories. For a short period of time every Radiobiology laboratory in the EU had to choose or improve applicable method of analysis, to develop working protocols and their own calibration curves for the applicable methods. The Scientific laboratory of Radiobiology and Radia tion protec tion,\nMilit ary Medical Academy Sofia is responsible for biodosimetr y esti mation of the assessment\ndose to the military structures in Bulgaria . Aim of the study: The aim of the current study is to analyze and compare some of the current biodosimetry methods, used in the European laboratories. Selection of a part of the analyzed methods for current use in one of the Bulgarian radiobiology laboratories; Materials and methods: comparison of the advantages and disadvantages of the most used radiobiology methods used in the EU radiobiology laboratories such as Dicentric chromosomal assay (DCA), cytokinesis-block micronucleus assay (CBMN), premature chromosome condensation assay (PCC) and fluorescence in situ hybridization (FISH) chromosomal analysis. Results: The detailed analysis and review of the applied European methods, give the priority to the golden standard method (DCA), as the most applicable, shorten and highly effective for the needs of S cientific laboratory of Radiobiology and Radia tio n\nprotec tion, Milit ary Medical Academy SofiaSofia. The advantages of the FISH technique show a good perspective and could be performed for biodosimetry in the laboratory. Conclusion: The biodosimetry assessment of the absorbed dose is a high skilled activity that involves team of professionals, working in the laboratory, correct selection of a few appropriate methods and preliminary optimization of the process. Take into consideration all described factors for our routine work use of DCA method is the first and optimal option. The FISH-technique presents many advantages that makes it a good additional option.","internal_url":"https://www.academia.edu/123502163/Overview_of_some_of_the_current_biodosimetry_methods_for_evaluation_of_the_assessment_dose_after_ionizing_exposure_in_the_EU_laboratories_Applicable_biodosimetry_methods_in_Bulgaria","translated_internal_url":"","created_at":"2024-09-02T23:37:45.472-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42318998,"work_id":123502163,"tagging_user_id":298664184,"tagged_user_id":298664184,"co_author_invite_id":8233017,"email":"g***a@gmail.com","affiliation":"Military Medical Academy","display_order":1,"name":"Galina Racheva","title":"Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria."},{"id":42318999,"work_id":123502163,"tagging_user_id":298664184,"tagged_user_id":300103645,"co_author_invite_id":null,"email":"i***v@gmail.com","display_order":2,"name":"Ivan Kindekov","title":"Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria."},{"id":42319000,"work_id":123502163,"tagging_user_id":298664184,"tagged_user_id":324569284,"co_author_invite_id":8233018,"email":"v***e@abv.bg","display_order":3,"name":"Todorova P","title":"Overview of some of the current biodosimetry methods for evaluation of the assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria."}],"downloadable_attachments":[{"id":117918562,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117918562/thumbnails/1.jpg","file_name":"E13063235.pdf","download_url":"https://www.academia.edu/attachments/117918562/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Overview_of_some_of_the_current_biodosim.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117918562/E13063235-libre.pdf?1725348501=\u0026response-content-disposition=attachment%3B+filename%3DOverview_of_some_of_the_current_biodosim.pdf\u0026Expires=1732831889\u0026Signature=JTP4SebEigl-oZX5CaKg3g0Ur0vh-gelVWIUSqZaWTTvCur06mzaqw2oDEKJtn2Vl39eMR5MzgZFeAlp2l5yv0J6uXdjhFdFzljNQfXXiME9soINpbQKYaNNdIsQgpLA4oxADDH9pTOfjvPXml7zthaXY3nwx1bi2~n~9Roh6tZtnWICXB4lx8-WCBZCrIeB1mEqaLbe1zHsyVoIP5XkTt9MrsVVLnjR0bcRw08oUVIM3t~4MjH7WbFUX2zst29jaFnn5koRF~~afHwqvX8vSAo55F4L8Dfnve5k2JON~LcT8tvBNHZ0MlGedCXC9u1Sx~HqYg~ak7tgZ1-Z1zEORA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Overview_of_some_of_the_current_biodosimetry_methods_for_evaluation_of_the_assessment_dose_after_ionizing_exposure_in_the_EU_laboratories_Applicable_biodosimetry_methods_in_Bulgaria","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117918562,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117918562/thumbnails/1.jpg","file_name":"E13063235.pdf","download_url":"https://www.academia.edu/attachments/117918562/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Overview_of_some_of_the_current_biodosim.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117918562/E13063235-libre.pdf?1725348501=\u0026response-content-disposition=attachment%3B+filename%3DOverview_of_some_of_the_current_biodosim.pdf\u0026Expires=1732831889\u0026Signature=JTP4SebEigl-oZX5CaKg3g0Ur0vh-gelVWIUSqZaWTTvCur06mzaqw2oDEKJtn2Vl39eMR5MzgZFeAlp2l5yv0J6uXdjhFdFzljNQfXXiME9soINpbQKYaNNdIsQgpLA4oxADDH9pTOfjvPXml7zthaXY3nwx1bi2~n~9Roh6tZtnWICXB4lx8-WCBZCrIeB1mEqaLbe1zHsyVoIP5XkTt9MrsVVLnjR0bcRw08oUVIM3t~4MjH7WbFUX2zst29jaFnn5koRF~~afHwqvX8vSAo55F4L8Dfnve5k2JON~LcT8tvBNHZ0MlGedCXC9u1Sx~HqYg~ak7tgZ1-Z1zEORA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":10032,"name":"Radiation Protection","url":"https://www.academia.edu/Documents/in/Radiation_Protection"},{"id":18325,"name":"Radiobiology of Ionizing Radiation","url":"https://www.academia.edu/Documents/in/Radiobiology_of_Ionizing_Radiation"},{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":317806,"name":"Biodosimetry","url":"https://www.academia.edu/Documents/in/Biodosimetry"},{"id":801884,"name":"Cytogenetic Biodosimetry","url":"https://www.academia.edu/Documents/in/Cytogenetic_Biodosimetry"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123502125"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123502125/CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN_THE_ROUTINE_PRACTICE_EXAMPLES_OF_CHRONIC_MYELOID_LEUKEMIA"><img alt="Research paper thumbnail of CYTOGENETIC ANALYSIS OF HEMOBLASTOSES IN THE ROUTINE PRACTICE – EXAMPLES OF CHRONIC MYELOID LEUKEMIA" class="work-thumbnail" src="https://attachments.academia-assets.com/117918486/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123502125/CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN_THE_ROUTINE_PRACTICE_EXAMPLES_OF_CHRONIC_MYELOID_LEUKEMIA">CYTOGENETIC ANALYSIS OF HEMOBLASTOSES IN THE ROUTINE PRACTICE – EXAMPLES OF CHRONIC MYELOID LEUKEMIA</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0">Galina Racheva</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/TodorovaP1">Todorova P</a></span></div><div class="wp-workCard_item"><span>Military Medicine</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The peripheral blood consists two main compartments – blood plasma and form elements (blood cell...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The peripheral blood consists two main compartments <br />– blood plasma and form elements (blood cells). The <br />peripheral blood consists of two main components – <br />blood plasma and formed elements (blood cells). <br />Hemoblastoses develop when mutations occur in the <br />precursors of blood cells (progenitor cells). The progenitor <br />cells of the blood cells are mostly known as <br />stem cells. Stem cells have strong proliferative potential <br />and differentiate to two main blood branches – <br />myeloid (derived from myeloid progenitor cells) and <br />lymphoid (derived from lymphoid progenitor cells). <br />Under the action of various hematopoietic growth factors, <br />they differentiate into different cell types of their order [3]. Leukemias are a group of oncological diseases <br />characterized by an increase of the leukocytes <br />in the bone marrow and blood. Depending on the progression <br />of the disease, they are acute and chronic, <br />and according to the origin of the affected cells – myeloid <br />and lymphoid. Combinations between them give <br />four main categories [7]. The presence of certain chromosomal <br />markers underlies the WHO cancer classification. <br />Their observation is necessary to confirm or <br />reject a previously established diagnosis. The diagnosis <br />is made based on the clinical expertise, laboratory <br />tests and the observation of the specific cytogenetic <br />markers. <br />Chronic myeloid (myelogenous) leukemia is hemoblastosis, <br />which affect the cells of the myeloid branch. This <br />disease is characterized by the presence of a specific <br />chromosomal marker – Ph-chromosome. The presence <br />of the Ph-chromosome can be determined by <br />cytogenetic analysis. Cytogenetic analysis has a crucial <br />role in the diagnostic process and therapeutic response <br />in patients with hemoblastoses.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cb99c854cf685a1c3dcf7f50d88f33c4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117918486,"asset_id":123502125,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117918486/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123502125"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123502125"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123502125; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123502125]").text(description); $(".js-view-count[data-work-id=123502125]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123502125; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123502125']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123502125, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cb99c854cf685a1c3dcf7f50d88f33c4" } } $('.js-work-strip[data-work-id=123502125]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123502125,"title":"CYTOGENETIC ANALYSIS OF HEMOBLASTOSES\r\nIN THE ROUTINE PRACTICE – EXAMPLES OF\r\nCHRONIC MYELOID LEUKEMIA","translated_title":"","metadata":{"issue":"3","volume":"LXXV","abstract":"The peripheral blood consists two main compartments\r\n– blood plasma and form elements (blood cells). The\r\nperipheral blood consists of two main components –\r\nblood plasma and formed elements (blood cells).\r\nHemoblastoses develop when mutations occur in the\r\nprecursors of blood cells (progenitor cells). The progenitor\r\ncells of the blood cells are mostly known as\r\nstem cells. Stem cells have strong proliferative potential\r\nand differentiate to two main blood branches –\r\nmyeloid (derived from myeloid progenitor cells) and\r\nlymphoid (derived from lymphoid progenitor cells).\r\nUnder the action of various hematopoietic growth factors,\r\nthey differentiate into different cell types of their order [3]. Leukemias are a group of oncological diseases\r\ncharacterized by an increase of the leukocytes\r\nin the bone marrow and blood. Depending on the progression\r\nof the disease, they are acute and chronic,\r\nand according to the origin of the affected cells – myeloid\r\nand lymphoid. Combinations between them give\r\nfour main categories [7]. The presence of certain chromosomal\r\nmarkers underlies the WHO cancer classification.\r\nTheir observation is necessary to confirm or\r\nreject a previously established diagnosis. The diagnosis\r\nis made based on the clinical expertise, laboratory\r\ntests and the observation of the specific cytogenetic\r\nmarkers.\r\nChronic myeloid (myelogenous) leukemia is hemoblastosis,\r\nwhich affect the cells of the myeloid branch. This\r\ndisease is characterized by the presence of a specific\r\nchromosomal marker – Ph-chromosome. The presence\r\nof the Ph-chromosome can be determined by\r\ncytogenetic analysis. Cytogenetic analysis has a crucial\r\nrole in the diagnostic process and therapeutic response\r\nin patients with hemoblastoses.","publisher":"MILITARY MEDICINE OFFICIAL EDITION OF MILITARY MEDICAL ACADEMY AND BULGARIAN SCIENTIFIC SOCIETY OF MILITARY MEDICINE","page_numbers":"23-29","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Military Medicine"},"translated_abstract":"The peripheral blood consists two main compartments\r\n– blood plasma and form elements (blood cells). The\r\nperipheral blood consists of two main components –\r\nblood plasma and formed elements (blood cells).\r\nHemoblastoses develop when mutations occur in the\r\nprecursors of blood cells (progenitor cells). The progenitor\r\ncells of the blood cells are mostly known as\r\nstem cells. Stem cells have strong proliferative potential\r\nand differentiate to two main blood branches –\r\nmyeloid (derived from myeloid progenitor cells) and\r\nlymphoid (derived from lymphoid progenitor cells).\r\nUnder the action of various hematopoietic growth factors,\r\nthey differentiate into different cell types of their order [3]. Leukemias are a group of oncological diseases\r\ncharacterized by an increase of the leukocytes\r\nin the bone marrow and blood. Depending on the progression\r\nof the disease, they are acute and chronic,\r\nand according to the origin of the affected cells – myeloid\r\nand lymphoid. Combinations between them give\r\nfour main categories [7]. The presence of certain chromosomal\r\nmarkers underlies the WHO cancer classification.\r\nTheir observation is necessary to confirm or\r\nreject a previously established diagnosis. The diagnosis\r\nis made based on the clinical expertise, laboratory\r\ntests and the observation of the specific cytogenetic\r\nmarkers.\r\nChronic myeloid (myelogenous) leukemia is hemoblastosis,\r\nwhich affect the cells of the myeloid branch. This\r\ndisease is characterized by the presence of a specific\r\nchromosomal marker – Ph-chromosome. The presence\r\nof the Ph-chromosome can be determined by\r\ncytogenetic analysis. Cytogenetic analysis has a crucial\r\nrole in the diagnostic process and therapeutic response\r\nin patients with hemoblastoses.","internal_url":"https://www.academia.edu/123502125/CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN_THE_ROUTINE_PRACTICE_EXAMPLES_OF_CHRONIC_MYELOID_LEUKEMIA","translated_internal_url":"","created_at":"2024-09-02T23:35:48.112-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":298664184,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42319058,"work_id":123502125,"tagging_user_id":298664184,"tagged_user_id":300103645,"co_author_invite_id":null,"email":"i***v@gmail.com","display_order":1,"name":"Ivan Kindekov","title":"CYTOGENETIC ANALYSIS OF HEMOBLASTOSES\r\nIN THE ROUTINE PRACTICE – EXAMPLES OF\r\nCHRONIC MYELOID LEUKEMIA"},{"id":42319059,"work_id":123502125,"tagging_user_id":298664184,"tagged_user_id":324569284,"co_author_invite_id":8233018,"email":"v***e@abv.bg","display_order":2,"name":"Todorova P","title":"CYTOGENETIC ANALYSIS OF HEMOBLASTOSES\r\nIN THE ROUTINE PRACTICE – EXAMPLES OF\r\nCHRONIC MYELOID LEUKEMIA"}],"downloadable_attachments":[{"id":117918486,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117918486/thumbnails/1.jpg","file_name":"23_29.pdf","download_url":"https://www.academia.edu/attachments/117918486/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117918486/23_29-libre.pdf?1725348528=\u0026response-content-disposition=attachment%3B+filename%3DCYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN.pdf\u0026Expires=1732831889\u0026Signature=PP~OtQIEwFGf3SJ3xuJuh-Zz0ODFIsAz6rutm1sxGXV4d-Kqx4bd0NipDASgtpSL5NID8N3iDYiQvOLQDFHJR2VF1Tk8iUtVJom2Kzipp7nxT8tMOBD8LMvNqsexc~OGERCobqbRlRwiu69cJi-Uk0cNA7-tTgGMfOy3qbP5vofLeAdOfvyfJZC838cUv02-lps2KtlgtSisVHSXzeLDxI0Waou5~Jxz7ZatcyQ~w~9NPwrQ8ZFx2j0-rV-jH3z8AtRKHuMJ8BF1jmIqtpJWljIRwA~V1BXC31Z6qa-czlPSAmKrWzbeQbs7mi9y1StcFyPR-Jpj5cd4Iug2J0Lncw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN_THE_ROUTINE_PRACTICE_EXAMPLES_OF_CHRONIC_MYELOID_LEUKEMIA","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":298664184,"first_name":"Galina","middle_initials":null,"last_name":"Racheva","page_name":"ГалинаРачева","domain_name":"vmeda","created_at":"2024-01-09T05:16:20.133-08:00","display_name":"Galina Racheva","url":"https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"},"attachments":[{"id":117918486,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117918486/thumbnails/1.jpg","file_name":"23_29.pdf","download_url":"https://www.academia.edu/attachments/117918486/download_file?st=MTczMjg0NTA4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"CYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117918486/23_29-libre.pdf?1725348528=\u0026response-content-disposition=attachment%3B+filename%3DCYTOGENETIC_ANALYSIS_OF_HEMOBLASTOSES_IN.pdf\u0026Expires=1732831889\u0026Signature=PP~OtQIEwFGf3SJ3xuJuh-Zz0ODFIsAz6rutm1sxGXV4d-Kqx4bd0NipDASgtpSL5NID8N3iDYiQvOLQDFHJR2VF1Tk8iUtVJom2Kzipp7nxT8tMOBD8LMvNqsexc~OGERCobqbRlRwiu69cJi-Uk0cNA7-tTgGMfOy3qbP5vofLeAdOfvyfJZC838cUv02-lps2KtlgtSisVHSXzeLDxI0Waou5~Jxz7ZatcyQ~w~9NPwrQ8ZFx2j0-rV-jH3z8AtRKHuMJ8BF1jmIqtpJWljIRwA~V1BXC31Z6qa-czlPSAmKrWzbeQbs7mi9y1StcFyPR-Jpj5cd4Iug2J0Lncw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":50994,"name":"Genetics and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":53424,"name":"Chronic Myeloid Leukaemia","url":"https://www.academia.edu/Documents/in/Chronic_Myeloid_Leukaemia"}],"urls":[{"id":44430882,"url":"https://www.vma.bg/%D0%92%D0%BE%D0%B5%D0%BD%D0%BD%D0%B0-%D0%9C%D0%B5%D0%B4%D0%B8%D1%86%D0%B8%D0%BD%D0%B0-2023.html"}]}, dispatcherData: dispatcherData }); 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