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(PDF) Study of the ionizing radiation protection activity of two natural amino acids N-acetyl-L-cysteine and trimethylglycine
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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F124124933%2FStudy_of_the_ionizing_radiation_protection_activity_of_two_natural_amino_acids_N_acetyl_L_cysteine_and_trimethylglycine%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":118405619,"identifier":"Attachment_118405619","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":124124933,"created_at":"2024-09-24T00:54:12.397-07:00","from_world_paper_id":259533724,"updated_at":"2025-01-10T14:57:35.432-08:00","_data":{"ai_abstract":"The discovery and use of appropriate ionizing radiation protectors could significantly reduce the risk of acute radiation syndrome or chronic radiation damages (leukemia or solid tumors) after irradiation with relatively high doses radiation. During the last years of research, it was discovered that natural and cellular metabolites could be used for prevention against ionizing radiation, as non-toxic ionizing radiation protectors. The current study was focused to examine the ionizing radiation protection activity of two natural amino acids N-acetyl-L-cysteine and trimethylglycine (betaine, (CH3)3N+CH2CO2) and their ability to prevent the development or to reduce the extent of the radiation damage. The whole survey was performed on peripheral blood lymphocytes cell cultures of healthy donors. We have used multiple methods to determine the radiation dose, the concentration of the examined substances and to analyze the radiation protection activity of the test substances. For the current survey, we used research methods such as cellular culturing, ELISA-test, dicentric chromosomes assay IR-induced cytokinesis-block micronucleus assay for generated micronuclei (MNs) in bi-nucleated cells, RT-PCR, DNA-labeling and assay of the oxidative stress. The survey results showed significant reduction of the radiation-induced DNA damages, especially in combination of both analyzed substances. Those results show correlation to the strong anti-oxidative stress activity of both amino acids.","publication_date":"2019,,","publication_name":"Archives in Cancer Research"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"low","language":"en","title":"Study of the ionizing radiation protection activity of two natural amino acids N-acetyl-L-cysteine and trimethylglycine","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [298664184]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":118405619,"attachmentType":"pdf"}"><img alt="First page of “Study of the ionizing radiation protection activity of two natural amino acids N-acetyl-L-cysteine and trimethylglycine”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/118405619/mini_magick20240924-1-ip2ls8.png?1727164515" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Study of the ionizing radiation protection activity of two natural amino acids N-acetyl-L-cysteine and trimethylglycine</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="298664184" href="https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0"><img alt="Profile image of Galina Racheva" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/298664184/144445076/155152469/s65__._.jpg" />Galina Racheva</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2019, Archives in Cancer Research</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">1 page</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 124124933; 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if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--detail ds2-5-body-md">AI-generated Abstract</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">The discovery and use of appropriate ionizing radiation protectors could significantly reduce the risk of acute radiation syndrome or chronic radiation damages (leukemia or solid tumors) after irradiation with relatively high doses radiation. During the last years of research, it was discovered that natural and cellular metabolites could be used for prevention against ionizing radiation, as non-toxic ionizing radiation protectors. The current study was focused to examine the ionizing radiation protection activity of two natural amino acids N-acetyl-L-cysteine and trimethylglycine (betaine, (CH3)3N+CH2CO2) and their ability to prevent the development or to reduce the extent of the radiation damage. The whole survey was performed on peripheral blood lymphocytes cell cultures of healthy donors. We have used multiple methods to determine the radiation dose, the concentration of the examined substances and to analyze the radiation protection activity of the test substances. For the current survey, we used research methods such as cellular culturing, ELISA-test, dicentric chromosomes assay IR-induced cytokinesis-block micronucleus assay for generated micronuclei (MNs) in bi-nucleated cells, RT-PCR, DNA-labeling and assay of the oxidative stress. The survey results showed significant reduction of the radiation-induced DNA damages, especially in combination of both analyzed substances. Those results show correlation to the strong anti-oxidative stress activity of both amino acids.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":118405619,"attachmentType":"pdf","workUrl":"https://www.academia.edu/124124933/Study_of_the_ionizing_radiation_protection_activity_of_two_natural_amino_acids_N_acetyl_L_cysteine_and_trimethylglycine"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":118405619,"attachmentType":"pdf","workUrl":"https://www.academia.edu/124124933/Study_of_the_ionizing_radiation_protection_activity_of_two_natural_amino_acids_N_acetyl_L_cysteine_and_trimethylglycine"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas" data-impression-entity-id="124124933" data-impression-entity-type="2" data-impression-source="signup-banner"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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The TP53 gene is known as a "guardian of the genome" and is a tumor suppressor gene. Its role is to keep the cell of malignant transformation. After ionizing radiation exposure, the TP53 could mutate and the cell could continue to active proliferation (tumor cellular transformation). It has been noticed that different type of substances could have radioprotective effect and to protect the cell of malignant transformation, apoptosis, genome injuries or necrosis. Some of the natural metabolites that are proven antioxidants, show significant ability of radiation protection of the cells. The aim of that study is to analyze the possible radioprotection ability of two origin metabolites (amino acids)-trimethyl glycine (betaine) and N-acetyl-L-cysteine, applied together and in combination, first before irradiation (preventive treatment) and then 2 hours after irradiation (as a therapeutic agents). The research work is done as invitro analysis to peripheral blood cell cultures. Conclusion: The conclusion of the study is that both amino acids showed good radiation protection activity after in-vitro performed analysis. The most significant results showed the combination of both natural metabolites.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Research of the Potential Radioprotective Activity of Trimethyl Glycine and N-Acetyl-L-Cysteine with Quantitative Analysis Using Real-Time Polymerase Chain Reaction (QRT-PCR)","attachmentId":118405600,"attachmentType":"pdf","work_url":"https://www.academia.edu/124124936/Research_of_the_Potential_Radioprotective_Activity_of_Trimethyl_Glycine_and_N_Acetyl_L_Cysteine_with_Quantitative_Analysis_Using_Real_Time_Polymerase_Chain_Reaction_QRT_PCR_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/124124936/Research_of_the_Potential_Radioprotective_Activity_of_Trimethyl_Glycine_and_N_Acetyl_L_Cysteine_with_Quantitative_Analysis_Using_Real_Time_Polymerase_Chain_Reaction_QRT_PCR_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="123503107" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/123503107/Qualitatively_determine_the_possible_radioprotective_ability_of_the_amino_acids_N_acetyl_L_cysteine_and_N_N_N_trimethyl_glycine_betaine">Qualitatively determine the possible radioprotective ability of the amino acids N-acetyl-L-cysteine and N,N,N-trimethyl glycine (betaine</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="298664184" href="https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0">Galina Racheva</a></div><p class="ds-related-work--metadata ds2-5-body-xs">World scientific news , 2024</p><p class="ds-related-work--abstract ds2-5-body-sm">Ionizing radiation exposure induces severe cellular injuries, such as single-and double-strand breaks, base lost, base's changes, chromosomal aberrations, etc. Double strand breaks are the most significant and dangerous for the cell. As a result of action of the ionizing radiation the level of free radicals (more specific reactive oxygen species) increases many times and leads to severe cellular injuries. Oxidative stress has appeared. Double strand breaks could lead to formation of genomic instability that could become a stable change and to mutate the cell. High doses of ionizing radiation led to destroying of the whole DNA-genome and to formation of DNA-fragmentation. The aim of the currents study is to qualitatively determine the possible radioprotective ability of the amino acids Nacetyl-L-cysteine and N,N,N-trimethyl glycine (betaine). DNA-ladders method has been used for conformation of the radioprotective activity of analyzed two amino acids (betaine and N-acetyl-Lcysteine). The obtained result of the conducted research showed a possible high potential for radioprotective ability of both metabolites and set the stage for additional studies in an experimental cell model to confirm or reject the result.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Qualitatively determine the possible radioprotective ability of the amino acids N-acetyl-L-cysteine and N,N,N-trimethyl glycine (betaine","attachmentId":117919208,"attachmentType":"pdf","work_url":"https://www.academia.edu/123503107/Qualitatively_determine_the_possible_radioprotective_ability_of_the_amino_acids_N_acetyl_L_cysteine_and_N_N_N_trimethyl_glycine_betaine","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/123503107/Qualitatively_determine_the_possible_radioprotective_ability_of_the_amino_acids_N_acetyl_L_cysteine_and_N_N_N_trimethyl_glycine_betaine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="126995886" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/126995886/Examine_of_the_Potential_Radiation_Protection_Ability_of_Amino_Acid_Betaine_N_N_N_Trimethyl_Glycine_against_the_Cellular_Harmful_Effect_of_the_Ionizing_Radiation_in_Animal_Experimental_Models">Examine of the Potential Radiation Protection Ability of Amino Acid Betaine (N, N, N-Trimethyl Glycine) against the Cellular Harmful Effect of the Ionizing Radiation in Animal Experimental Models</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="298664184" href="https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0">Galina Racheva</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="300103645" href="https://independent.academia.edu/IvanKindekov">Ivan Kindekov</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Annals of Agri-Bio Research, 2024</p><p class="ds-related-work--abstract ds2-5-body-sm">The serious harmful effect of the ionizing radiation, leads the researchers to search for new effective substances with radiation protection activity. The damaging effect of the ionizing radiation exposure is one of the most dangerous professional circumstances for the pilots and astronauts. Have been found that normal cellular antioxidant metabolites, could be effective radioprotectors. The antioxidants’ potential to reduce the cellular damage in animal models have been studied for more than 50 years. In last decade a lot of normal cellular metabolites such as amino acids, nucleotides, fatty acids, etc. were researched for potential antioxidant activity. The amino acids are highly active metabolites that participate in various anabolic and catabolic processes. The high metabolic activity determine their active role in neutralizing reactive oxygen species (ROS, free radicals) and accordingly high antioxidant activity. AIM: Follow up of the after-radiation exposure recovery and radiation protection activity of betaine (N, N, N-trimethyl glycine) applied to experimental animals (mice). MATERIALS AND METHODS: Have been used 120 experimental animals (white male mice C3H, with body weight 23 gr), supplied by the “Certified vivarium for experimental animals”, Military Medical Academy-Sofia. They were divided in four experimental groups. Two of the experimental groups were exposed to radiation by 137Cs-source with power 2,05 Gy/min (The Institute of Plant Physiology and Genetics “Acad. D. Kostov”, Bulgarian Academy of Science, Sofia). The amino acid betaine has been applied peroral as a food supplement. For the purpose of the current study was controlled the following index: Cu/Zn SOD protein expression in three radiation sensitive organs (liver, spleen and testicles). The protein expression is confirmed by Western blot analysis. RESULTS: The obtained results gave the opportunity to perform comparative analysis of protein expression of Cu/ZnSOD in three different organs (liver, spleen and testicles) and to confirm the positive radiation protection effect of the researched substance. CONCLUSION: Betaine (N, N, N-trimethyl glycine) showed positive effect to the survival rate in all examined experimental animals’ groups. The application of Betaine induced increase of the expression of Cu/Zn SOD protein in the researched experimental groups.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Examine of the Potential Radiation Protection Ability of Amino Acid Betaine (N, N, N-Trimethyl Glycine) against the Cellular Harmful Effect of the Ionizing Radiation in Animal Experimental Models","attachmentId":120793179,"attachmentType":"pdf","work_url":"https://www.academia.edu/126995886/Examine_of_the_Potential_Radiation_Protection_Ability_of_Amino_Acid_Betaine_N_N_N_Trimethyl_Glycine_against_the_Cellular_Harmful_Effect_of_the_Ionizing_Radiation_in_Animal_Experimental_Models","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/126995886/Examine_of_the_Potential_Radiation_Protection_Ability_of_Amino_Acid_Betaine_N_N_N_Trimethyl_Glycine_against_the_Cellular_Harmful_Effect_of_the_Ionizing_Radiation_in_Animal_Experimental_Models"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="123503454" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/123503454/Research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis">Research of the potential radioprotective activity of trimethyl glycine and nacetyllcysteine with quantitative analysis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="298664184" href="https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0">Galina Racheva</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Medical & Clinical Research, 2024</p><p class="ds-related-work--abstract ds2-5-body-sm">Abstract The irradiation exposure could affect the cellular genome and specifically target genes, such as TP53 gene. The TP53 gene is known as a “guardian of the genome” and is a tumor suppressor gene. Its role is to keep the cell of malignant transformation. After ionizing radiation exposure, the TP53 could mutate and the cell could continue to active proliferation (tumor cellular transformation). It has been noticed that different type of substances could have radioprotective effect and to protect the cell of malignant transformation, apoptosis, genome injuries or necrosis. Some of the natural metabolites that are proven antioxidants, show significant ability of radiation protection of the cells. The aim of that study is to analyze the possible radioprotection ability of two origin metabolites (amino acids)–trimethyl glycine (betaine) and N-acetyl-L-cysteine, applied together and in combination, first before irradiation (preventive treatment) and then 2 hours after irradiation (as a therapeutic agents). The research work is done as invitro analysis to peripheral blood cell cultures. Conclusion: The conclusion of the study is that both amino acids showed good radiation protection activity after in-vitro performed analysis. The most significant results showed the combination of both natural metabolit</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Research of the potential radioprotective activity of trimethyl glycine and nacetyllcysteine with quantitative analysis","attachmentId":117919396,"attachmentType":"pdf","work_url":"https://www.academia.edu/123503454/Research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/123503454/Research_of_the_potential_radioprotective_activity_of_trimethyl_glycine_and_nacetyllcysteine_with_quantitative_analysis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="123502985" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/123502985/Amino_Acid_Betaine_Trimethyl_Glycine_As_A_Factor_Of_Recovery_Of_The_Hemopoietic_Syndrome_Induced_By_The_Ionizing_Radiation">Amino Acid Betaine (Trimethyl Glycine) As A Factor Of Recovery Of The Hemopoietic Syndrome, Induced By The Ionizing Radiation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="298664184" href="https://vmeda.academia.edu/%D0%93%D0%B0%D0%BB%D0%B8%D0%BD%D0%B0%D0%A0%D0%B0%D1%87%D0%B5%D0%B2%D0%B0">Galina Racheva</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="300103645" href="https://independent.academia.edu/IvanKindekov">Ivan Kindekov</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Overview of some of the current biodosimet ry methods for evaluation o f t he assessment dose after ionizing exposure in the EU laboratories Applicable biodosimetry methods in Bulgaria, 2024</p><p class="ds-related-work--abstract ds2-5-body-sm">The radioprotection activity of different substances, such as cellular metabolites with antioxidant activity to reduce the cellular damage induced by ionizing radiation has been studied for more than 50 years. Many research studies are focused on the radioprotective efficacy of naturally occurring antioxidants (natural metabolites), and how they might influence various endpoints of radiation damage. Aim: in the current study has been research the irradiation recovery and possible antioxidant activity after feeding the experimental animals with trimethyl glycine (betaine), as a food supplement. Materials and methods: in the current study were used experimental modal animals (white male mice c3h, weight 23 gr.) That were divided in four groups. Two of the groups were exposed to radiation from 137 cs with power 2,05 gy/min. The food supplement has been administrated to three of the experimental groups of animals, peroral, every day during 15 days before irradiation of those that are exposed. Lipid peroxidation levels in liver, spleen and testis were followed to all of the groups. Results: the research analysis gave significant results of decrease the levels of lipid peroxidation (in liver, spleen and testis), comparing the measurements in four different groups for every organcontrol group with irradiation without feeding, control group without irradiation with feeding, experimental group with irradiation and feeding. Conclusion: the researched amino acid has positive effect over survival rate in experimental animals. Administration of the amino acid shows decrease of the oxidative stress in the experimental group in comparison to control group with irradiation.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Amino Acid Betaine (Trimethyl Glycine) As A Factor Of Recovery Of The Hemopoietic Syndrome, Induced By The Ionizing Radiation","attachmentId":117919127,"attachmentType":"pdf","work_url":"https://www.academia.edu/123502985/Amino_Acid_Betaine_Trimethyl_Glycine_As_A_Factor_Of_Recovery_Of_The_Hemopoietic_Syndrome_Induced_By_The_Ionizing_Radiation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/123502985/Amino_Acid_Betaine_Trimethyl_Glycine_As_A_Factor_Of_Recovery_Of_The_Hemopoietic_Syndrome_Induced_By_The_Ionizing_Radiation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="57604364" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/57604364/Radioprotective_action_of_aminothiols_in_vitro_and_in_vivo_Comparison_between_effects_on_DNA_damage_and_cell_survival">Radioprotective action of aminothiols in vitro and in vivo: Comparison between effects on DNA damage and cell survival</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="118678288" href="https://independent.academia.edu/SusannavanAnkeren">Susanna vanAnkeren</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pharmacology & Therapeutics, 1988</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Radioprotective action of aminothiols in vitro and in vivo: Comparison between effects on DNA damage and cell survival","attachmentId":72424844,"attachmentType":"pdf","work_url":"https://www.academia.edu/57604364/Radioprotective_action_of_aminothiols_in_vitro_and_in_vivo_Comparison_between_effects_on_DNA_damage_and_cell_survival","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/57604364/Radioprotective_action_of_aminothiols_in_vitro_and_in_vivo_Comparison_between_effects_on_DNA_damage_and_cell_survival"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="52372095" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/52372095/A_New_Insight_on_the_Radioprotective_Potential_of_Epsilon_Aminocaproic_Acid">A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3075312" href="https://nu-kz.academia.edu/TimurSaliev">Timur Saliev</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Medicina</p><p class="ds-related-work--abstract ds2-5-body-sm">Background and objectives: The aim of the study was to scrutinize the ability of epsilon-aminocaproic acid (EACA) to prevent radiation-induced damage to human cells. Materials and Methods: Human peripheral blood mononuclear cells (PBMCs) were exposed to ionizing radiation at three low doses (22.62 mGy, 45.27 mGy, and 67.88 mGy) in the presence of EACA at the concentration of 50 ng/mL. Results: EACA was able to prevent cell death induced by low-dose X-ray radiation and suppress the formation of reactive oxygen species (ROS). EACA also demonstrated a capacity to protect DNA from radiation-induced damage. The data indicated that EACA is capable of suppression of radiation-induced apoptosis. Comparative tests of antioxidative activity of EACA and a range of free radical scavengers showed an ability of EACA to effectively inhibit the generation of ROS. Conclusions: This study showed that the pretreatment of PBMCs with EACA is able to protect the cells from radiation-elicited damage, incl...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid","attachmentId":69666714,"attachmentType":"pdf","work_url":"https://www.academia.edu/52372095/A_New_Insight_on_the_Radioprotective_Potential_of_Epsilon_Aminocaproic_Acid","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/52372095/A_New_Insight_on_the_Radioprotective_Potential_of_Epsilon_Aminocaproic_Acid"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="6296928" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/6296928/N_acetyl_cysteine_protects_against_ionizing_radiation_induced_DNA_damage_but_not_against_cell_killing_in_yeast_and_mammals">N-acetyl cysteine protects against ionizing radiation-induced DNA damage but not against cell killing in yeast and mammals</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="9761944" href="https://independent.academia.edu/ZhannaSobol">Zhanna Sobol</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32254045" href="https://independent.academia.edu/RamuneReliene">Ramune Reliene</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Mutation Research-fundamental and Molecular Mechanisms of Mutagenesis, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">Ionizing radiation (IR) induces DNA strand breaks leading to cell death or deleterious genome rearrangements. In the present study, we examined the role of N-acetyl-L-cysteine (NAC), a clinically proven safe agent, for it's ability to protect against ␥-ray-induced DNA strand breaks and/or DNA deletions in yeast and mammals. In the yeast Saccharomyces cerevisiae, DNA deletions were scored by reversion to histidine prototrophy. Human lymphoblastoid cells were examined for the frequency of ␥-H2AX foci formation, indicative of DNA double strand break formation. DNA strand breaks were also measured in mouse peripheral blood by the alkaline comet assay. In yeast, NAC reduced the frequency of IR-induced DNA deletions. However, NAC did not protect against cell death. NAC also reduced ␥-H2AX foci formation in human lymphoblastoid cells but had no protective effect in the colony survival assay. NAC administration via drinking water fully protected against DNA strand breaks in mice whole-body irradiated with 1 Gy but not with 4 Gy. NAC treatment in the absence of irradiation was not genotoxic. These data suggest that, given the safety and efficacy of NAC in humans, NAC may be useful in radiation therapy to prevent radiation-mediated genotoxicity, but does not interfere with efficient cancer cell killing.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"N-acetyl cysteine protects against ionizing radiation-induced DNA damage but not against cell killing in yeast and mammals","attachmentId":48926920,"attachmentType":"pdf","work_url":"https://www.academia.edu/6296928/N_acetyl_cysteine_protects_against_ionizing_radiation_induced_DNA_damage_but_not_against_cell_killing_in_yeast_and_mammals","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/6296928/N_acetyl_cysteine_protects_against_ionizing_radiation_induced_DNA_damage_but_not_against_cell_killing_in_yeast_and_mammals"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="38426607" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/38426607/The_effect_of_2_aminopropyl_amino_ethanethiol_WR1065_on_radiation_induced_DNA_damage_and_repair_and_cell_progression_in_V79_cells">The effect of 2-[(aminopropyl)amino] ethanethiol (WR1065) on radiation-induced DNA damage and repair and cell progression in V79 cells</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50547205" href="https://independent.academia.edu/BiserkaNagy">Biserka Nagy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">British journal of cancer, 1986</p><p class="ds-related-work--abstract ds2-5-body-sm">The radioprotector 2-[(aminopropyl)amino] ethanethiol (WR1065) was investigated with respect to its ability to affect radiation-induced DNA damage and repair in V79 cells. Studies were performed to evaluate the protector under conditions in which it is known to be effective in reducing the cytotoxic and mutagenic effects of gamma-irradiation. At a concentration of 4 mM, WR1065 protected against the formation of single strand breaks (SSB), as determined by the method of alkaline elution, when it was present during irradiation. The protector appeared, however, to inhibit the subsequent postirradiation repair or rejoining of SSB. While repair was complete within 24 h, the protector reduced the rate of repair by a factor of 3. This inhibitory effect on the rate of repair did not correlate with either measured differences in cell survival or mutagenesis. The radioprotector was also investigated with respect to its ability to affect cell cycle progression. WR1065 present in the growth med...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The effect of 2-[(aminopropyl)amino] ethanethiol (WR1065) on radiation-induced DNA damage and repair and cell progression in V79 cells","attachmentId":58486209,"attachmentType":"pdf","work_url":"https://www.academia.edu/38426607/The_effect_of_2_aminopropyl_amino_ethanethiol_WR1065_on_radiation_induced_DNA_damage_and_repair_and_cell_progression_in_V79_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/38426607/The_effect_of_2_aminopropyl_amino_ethanethiol_WR1065_on_radiation_induced_DNA_damage_and_repair_and_cell_progression_in_V79_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="13754253" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13754253/Antioxidant_role_of_N_acetyl_cysteine_isomers_following_high_dose_irradiation">Antioxidant role of N-acetyl cysteine isomers following high dose irradiation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32872159" href="https://mst.academia.edu/NuranErcal">Nuran Ercal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Free Radical Biology and Medicine, 2003</p><p class="ds-related-work--abstract ds2-5-body-sm">High dose, acute radiation exposure, as in radiation accidents, induces three clinical syndromes that reflect consequences of oxidative protein, lipid, and DNA damage to tissues such as intestine, lung, and liver. In the present study, we irradiated C57BL/6 mice with 18 Gy whole-body radiation (XRT) and evaluated N-acetyl cysteine (NAC) isomers LNAC and DNAC as potential radioprotectors under conditions that would model the gastrointestinal syndrome. We focused on tissues thought not immediately involved in the gastrointestinal syndrome. Both LNAC and DNAC protected the lung and red blood cells (RBC) from glutathione (GSH) depletion following radiation exposure. However, only LNAC also supplemented the spleen GSH levels following XRT. Protection from increased malondialdehyde (MDA) levels (lung) and increased 8-hydroxy-deoxyguanosine (8-oxo-dG) presence (liver) following XRT was observed with treatment by either isomer of NAC. These results imply that either NAC isomer can act as a radioprotectant against many aspects of oxidative damage; chirality is only important for certain aspects. This pattern would be consistent with direct action of NAC in many radioprotection and repair processes, with a delimited role for NAC in GSH synthesis in some aspects of the problem.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Antioxidant role of N-acetyl cysteine isomers following high dose irradiation","attachmentId":44991698,"attachmentType":"pdf","work_url":"https://www.academia.edu/13754253/Antioxidant_role_of_N_acetyl_cysteine_isomers_following_high_dose_irradiation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13754253/Antioxidant_role_of_N_acetyl_cysteine_isomers_following_high_dose_irradiation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":118405619,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":118405619,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_118405619" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="126843344" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/126843344/Protection_of_Ionizing_Radiation_Induced_Cytogenetic_Damage_by_Hydroalcoholic_Extract_of_Cynodon_Dactylon_in_Chinese_Hamster_Lung_Fibroblast_Cells_and_Human_Peripheral_Blood_Lymphocytes">Protection of Ionizing Radiation-Induced Cytogenetic Damage by Hydroalcoholic Extract of Cynodon Dactylon in Chinese Hamster Lung Fibroblast Cells and Human Peripheral Blood Lymphocytes</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="315464476" href="https://independent.academia.edu/DineshUpadhya">Dinesh Upadhya</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Environmental Pathology, Toxicology and Oncology, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Protection of Ionizing Radiation-Induced Cytogenetic Damage by Hydroalcoholic Extract of Cynodon Dactylon in Chinese Hamster Lung Fibroblast Cells and Human Peripheral Blood Lymphocytes","attachmentId":120661423,"attachmentType":"pdf","work_url":"https://www.academia.edu/126843344/Protection_of_Ionizing_Radiation_Induced_Cytogenetic_Damage_by_Hydroalcoholic_Extract_of_Cynodon_Dactylon_in_Chinese_Hamster_Lung_Fibroblast_Cells_and_Human_Peripheral_Blood_Lymphocytes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" 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href="https://barc.academia.edu/dharmendramaurya">dharmendra maurya</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Selected Topics in DNA Repair, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Role of Radioprotectors in the Inhibition of DNA Damage and Modulation of DNA Repair After Exposure to Gamma-Radiation","attachmentId":88225959,"attachmentType":"pdf","work_url":"https://www.academia.edu/82549613/Role_of_Radioprotectors_in_the_Inhibition_of_DNA_Damage_and_Modulation_of_DNA_Repair_After_Exposure_to_Gamma_Radiation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/109640327/The_effect_of_N_acetylcysteine_on_biomarkers_for_radiation_induced_oxidative_damage_in_a_rat_model">The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35121191" href="https://independent.academia.edu/SerkanG%C3%BCrg%C3%BCl">Serkan Gürgül</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PubMed, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat 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Samartha</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Utilization of cytogenetic biomarkers as a tool for assessment of radiation injury and evaluation of radiomodulatory effects of various medicinal plants - a review.","attachmentId":39422908,"attachmentType":"pdf","work_url":"https://www.academia.edu/17300534/Utilization_of_cytogenetic_biomarkers_as_a_tool_for_assessment_of_radiation_injury_and_evaluation_of_radiomodulatory_effects_of_various_medicinal_plants_a_review","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/17300534/Utilization_of_cytogenetic_biomarkers_as_a_tool_for_assessment_of_radiation_injury_and_evaluation_of_radiomodulatory_effects_of_various_medicinal_plants_a_review"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="27371652" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27371652/The_radioprotective_effect_of_a_new_aminothiol_20_PRA_">The radioprotective effect of a new aminothiol (20-PRA)</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="51427451" href="https://independent.academia.edu/MDolabela">M. Dolabela</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brazilian Journal of Medical and Biological Research, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The radioprotective effect of a new aminothiol (20-PRA)","attachmentId":47625918,"attachmentType":"pdf","work_url":"https://www.academia.edu/27371652/The_radioprotective_effect_of_a_new_aminothiol_20_PRA_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/27371652/The_radioprotective_effect_of_a_new_aminothiol_20_PRA_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="77285304" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/77285304/Utilization_of_cytogenetic_biomarkers_as_a_tool_for_assessment_of_radiation_injury_and_evaluation_of_radiomodulatory_effects_of_various_medicinal_plants_and_ndash_a_review">Utilization of cytogenetic biomarkers as a tool for assessment of radiation injury and evaluation of radiomodulatory effects of various medicinal plants &ndash; a review</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4169527" href="https://icmr.academia.edu/RavindraSamarth">Dr. Ravindra M. Samartha</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Drug Design, Development and Therapy, 2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Utilization of cytogenetic biomarkers as a tool for assessment of radiation injury and evaluation of radiomodulatory effects of various medicinal plants \u0026ndash; a review","attachmentId":84704386,"attachmentType":"pdf","work_url":"https://www.academia.edu/77285304/Utilization_of_cytogenetic_biomarkers_as_a_tool_for_assessment_of_radiation_injury_and_evaluation_of_radiomodulatory_effects_of_various_medicinal_plants_and_ndash_a_review","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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