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Imaging Starts Using Brand New Radiotracer from Nuclidium

<!doctype html><html lang="en"><head> <meta charset="utf-8"> <title>Imaging Starts Using Brand New Radiotracer from Nuclidium</title> <link rel="shortcut icon" href="https://oxfordglobal.com/hubfs/OXFORD_GLOBAL-LOGO_SYMBOL.jpg"> <meta name="description" content="The radiotracer is the first part of Nuclidium’s proposed ‘theranostic pipeline’ which aims to diagnose, stage, and then treat prostate cancer."> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta property="og:description" content="The radiotracer is the first part of Nuclidium’s proposed ‘theranostic pipeline’ which aims to diagnose, stage, and then treat prostate cancer."> <meta property="og:title" content="Imaging Starts Using Brand New Radiotracer from Nuclidium"> <meta name="twitter:description" content="The radiotracer is the first part of Nuclidium’s proposed ‘theranostic pipeline’ which aims to diagnose, stage, and then treat prostate cancer."> <meta name="twitter:title" content="Imaging Starts Using Brand New Radiotracer from Nuclidium"> <style> a.cta_button{-moz-box-sizing:content-box !important;-webkit-box-sizing:content-box !important;box-sizing:content-box !important;vertical-align:middle}.hs-breadcrumb-menu{list-style-type:none;margin:0px 0px 0px 0px;padding:0px 0px 0px 0px}.hs-breadcrumb-menu-item{float:left;padding:10px 0px 10px 10px}.hs-breadcrumb-menu-divider:before{content:'›';padding-left:10px}.hs-featured-image-link{border:0}.hs-featured-image{float:right;margin:0 0 20px 20px;max-width:50%}@media (max-width: 568px){.hs-featured-image{float:none;margin:0;width:100%;max-width:100%}}.hs-screen-reader-text{clip:rect(1px, 1px, 1px, 1px);height:1px;overflow:hidden;position:absolute !important;width:1px} </style> <link rel="stylesheet" href="https://oxfordglobal.com/hs-fs/hub/8696823/hub_generated/template_assets/135726131582/1732113079147/git/og-stage/css/main.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/fontawesome.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/brands.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/solid.min.css"> <!-- Editor Styles --> <style id="hs_editor_style" type="text/css"> #hs_cos_wrapper_module_17019620504109 { display: block !important; margin-bottom: 0px !important } </style> <!-- Added by GoogleAnalytics4 integration --> <script> var _hsp = window._hsp = window._hsp || []; window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} var useGoogleConsentModeV2 = true; var waitForUpdateMillis = 1000; if (!window._hsGoogleConsentRunOnce) { window._hsGoogleConsentRunOnce = true; gtag('consent', 'default', { 'ad_storage': 'denied', 'analytics_storage': 'denied', 'ad_user_data': 'denied', 'ad_personalization': 'denied', 'wait_for_update': waitForUpdateMillis }); if (useGoogleConsentModeV2) { _hsp.push(['useGoogleConsentModeV2']) } else { _hsp.push(['addPrivacyConsentListener', function(consent){ var hasAnalyticsConsent = consent && (consent.allowed || (consent.categories && consent.categories.analytics)); var hasAdsConsent = consent && (consent.allowed || (consent.categories && consent.categories.advertisement)); gtag('consent', 'update', { 'ad_storage': hasAdsConsent ? 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NuriPro binds to Prostate Specific Membrane Antigen (PSMA), an established <a href="https://oxfordglobal.com/precision-medicine/events/biomarkers-us-2024" rel="noopener" target="_blank">biomarker for the diagnosis, staging, and treatment of prostate cancer.</a></p> <p><strong>Read more:</strong></p> <ul> <li><a href="https://oxfordglobal.com/precision-medicine/resources/study-analyses-predictive-biomarkers-for-covid-19-icu-patient-mortality" rel="noopener" target="_blank">Study Analyses Predictive Biomarkers for COVID-19 ICU Patient Mortality</a></li> <li><a href="https://oxfordglobal.com/precision-medicine/resources/group-identify-prognostic-biomarker-for-sclc-and-treatment-using-chemotherapy" rel="noopener" target="_blank">Group Identify Prognostic Biomarker for SCLC and Treatment Using Chemotherapy</a></li> <li><a href="https://oxfordglobal.com/precision-medicine/resources/proteomic-analysis-of-serum-extracellular-vesicles-reveals-potential-biomarkers-for-neuroblastoma" rel="noopener" target="_blank">Proteomic Analysis of Serum Extracellular Vesicles Reveals Potential Biomarkers for Neuroblastoma</a></li> </ul> <p>Clinical testing of the NuriPro program is currently being conducted at Hoag Memorial Hospital Presbytarian in Newport Beach, CA. The investigator initiated, non-randomised phase I trial will evaluate the safety and efficacy of <sup>61</sup>Cu-NuriPro as a diagnostic imaging tool for prostate cancer.</p> <p>Gary Ulaner, Director of Molecular Imaging and Therapy at Hoag Memorial Hospital Presbyterian and Principal Investigator of the trial said: “Prostate cancer remains the most frequently diagnosed cancer and the second most common cause of cancer death in American men. Rapid and precise diagnosis is essential for effective treatment.”</p> <p>The trial will compare the candidate to an already FDA-approved, Fluorine-18 based, PSMA-targeting radiotracer. Nuclidium says that its radiotracer candidate can offer benefits when compared to other currently available solutions.</p> <p>“Copper-based candidates have shown greater imaging capacity with less toxicity in pre-clinical studies. Copper’s unique properties allow us to establish the first true theranostic pipeline that can achieve more accurate staging of the individual patient and more precise treatment of their disease,” said Leila Jaafar, CEO and Co-Founder of Nuclidium.</p> <p>She continued: “Our NuriPro diagnostic’s imaging profile can overcome both detection and production challenges for physicians and patients living with prostate cancer and we look forward to further exploring its potential.”</p> <p>Furthermore, Nuclidium’s candidate offers a 3.3 hour half-life, compared to the current average of 1 to 2 hours from existing products. This allows <sup>61</sup>Cu-NuriPro to have further distribution range after production.</p> <p>The company boasts ease of manufacture for their product at room temperature, which enables on-demand preparation and a simplified and easy-to-apply workflow with reduced need for laboratory equipment. Furthermore, Nuclidium also <a href="https://www.businesswire.com/news/home/20241021269969/en/NUCLIDIUM-Announces-First-Patient-Imaged-in-Phase-1-Study-Evaluating-61Cu-based-Radiotracer-in-Patients-with-PSMA-positive-Prostate-Cancer/?feedref=JjAwJuNHiystnCoBq_hl-bV7DTIYheT0D-1vT4_bKFzt_EW40VMdK6eG-WLfRGUE1fJraLPL1g6AeUGJlCTYs7Oafol48Kkc8KJgZoTHgMu0w8LYSbRdYOj2VdwnuKwa" rel="noopener" target="_blank">said a press release</a>: “It [<sup>61</sup>Cu-NuriPro] further enables delayed imaging, allowing for the detection of even the smallest metastases.”</p> <p>Regarding the latest results from the ongoing trial, Ulaner commented: “The first patient has not experienced any adverse events so far and the scan with <sup>61</sup>Cu-NuriPro showed more osseous lesions than <sup>18</sup>F-piflufolastat, at 1 hour post-injection. Also, the PET scans with <sup>61</sup>Cu-NuriPro identified more osseous lesions at 2 and 4 hours compared to 1 hour post-injection. These preliminary clinical findings are in accordance with the preclinical results and underline the potential, favourable imaging performance of <sup>61</sup>Cu-NuriPro.”</p> <p>Along with the diagnostic portion of the program, Nuclidium are also developing a therapeutic radionuclide <sup>67</sup>Cu-NuriPro (<sup>67</sup>Cu-NODAGA-PSMA I&amp;T) currently in its preclinical stages, which aims to treat patients with prostate cancer. The company aims to begin a phase I clinical trial of <sup>67</sup>Cu-NuriPro in 2025.</p> Upon successful completion of the trial, Nuclidium wants to advance their NuriPro program into a Phase I/II theranostic clinical trial. 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