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Keck Team Integrate Multi-Omics with Environmental Data for Precision Environmental Health
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Now, this study aims to integrate data from both inside and outside the body, incorporating information about the environment with multi-omics data.</p> <p>Precision environmental health aims to examine the factors in the built and natural environment which impact human health. The field aims to both create healthier surroundings and identify at-risk populations.</p> <p>Assistant Professor of Population and Public Health Sciences and lead author of the paper published in <a href="https://www.sciencedirect.com/science/article/pii/S0160412024005166?via%3Dihub" rel="noopener" target="_blank"><em>Environmental International</em></a><em>, </em>Jesse Goodrich told <a href="https://medicalxpress.com/news/2024-11-framework-leveraging-multi-omics-advance.html" rel="noopener" target="_blank">MedicalXpress</a>: "To showcase how our proposed methods can be used towards precision health investigations, we carried out a study examining how mercury exposure in utero might impact the risk of developing liver injury in childhood."</p> <p>"Previous research has shown that prenatal mercury exposure increases the risk of liver injury, but the biological mechanisms and pathways have not been well understood."</p> <p>In particular, the team wanted to identify novel biomarkers of prenatal mercury induced Metabolic dysfunction-Associated Fatty Liver Disease (MAFLD) and better understand the molecular pathways that link the prenatal mercury exposure to that disease.</p> <p>Goodrich said: "This approach identifies signatures in the blood, in this case MAFLD, that signal whether or not you are at risk for certain diseases based on your previous environmental exposures."</p> <p>He further explained how he and his team “identify biological mechanisms of how environmental factors actually cause disease."</p> <p>Based on these data, they can then begin to use their framework to identify children of high risk for MAFLD based on their exposure and multi-omics data. "This method is closely related to precision medicine, which uses genetics to predict disease outcome, but in precision environmental health, we are combining biological and environmental factors," he said.</p> <p>Goodrich further commented that the combination of multi-omic and environmental data in analysis will broaden the horizons of precision environmental health. Not only will it provide much needed understanding about how environment-related diseases develop, but it will also enable methods for the detection of high-risk patients. Furthermore, it will inform the development of new precision medicines for the treatment and prevention of said diseases.</p> <div class="content-body-footer"> </div> </div> <div class="content-sidebar"> <div class="related-event"> <h3 class="center">Related Events</h3> For more on this topic, you may be interested in our upcoming <a href="/precision-medicine/events/nextgen-omics-us-2025">NextGen Omics & Spatial Biology US 2025</a> </div> <div class="related-articles"> <h3 class="center">Related Resources</h3> <div class="article"> <a href="/precision-medicine/resources/new-mnd-early-diagnostic-test-a-game-changer-for-research-on-the-disease"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Biomarkers/New%20MND%20Early%20Diagnostic%20Test%20a%20Game-Changer%20for%20Research%20on%20the%20Disease.png" class="cover-graphic-image"> </div> </a><div class="content"><a href="/precision-medicine/resources/new-mnd-early-diagnostic-test-a-game-changer-for-research-on-the-disease"> <h4> New MND Early Diagnostic Test: a 'Game-Changer' for Research on the Disease </h4> <div class="abstract"> Detecting the aggregation of TDP-43 spells a new diagnostic tool for MND. </div> <div class="read-more"> <a href="/precision-medicine/resources/new-mnd-early-diagnostic-test-a-game-changer-for-research-on-the-disease" class="read-more-link">Read More</a> </div></a> </div> </div> <div class="article"> <a href="/precision-medicine/resources/oxford-globals-top-rd-stories-2023"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/R%26D%20Top%20Stories%20eBook%20Content%20Portal%20Image.png" class="cover-graphic-image"> </div> </a><div class="content"><a href="/precision-medicine/resources/oxford-globals-top-rd-stories-2023"> <h4> Top R&D Stories of 2023 </h4> <div class="abstract"> Through captivating articles, insight pieces, and spotlight interviews, we delve into the remarkable innovations, breakthroughs, and scientific marvels that have defined the landscape of research over the past year. </div> <div class="read-more"> <a href="/precision-medicine/resources/oxford-globals-top-rd-stories-2023" class="read-more-link">Read More</a> </div></a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="newsletter-cta"> <h2 class="heading">Subscribe to our newsletter</h2> <div class="message"> Sign up for our monthly Newsletter to keep up with all things Precision Medicine </div> <div class="button-wrapper"> <a href="#" class="button hs-cta-trigger-button hs-cta-trigger-button-177053686110">Newsletter Sign-Up</a> </div> </div> </main> <div data-global-resource-path="git/og-stage/templates/partials/footer.html"><footer class="website-footer flex flex-column g-20"> <div class="footer-columns"> <div class="footer-column"> <a href="https://oxfordglobal.com" class="site-logo-link"> <img src="https://oxfordglobal.com/wp-content/uploads/2023/03/Oxford-Global-Logo-Stacked-Websize.png" class="site-logo"> </a> </div> <div class="footer-column"> <h3>Brands</h3> <ul> <li> <a href="/precision-medicine/">Precision Medicine</a> </li> <li> <a href="/discovery-development/">Discovery & Development</a> </li> <li> <a href="/nextgen-biomed/">NextGen Biomed</a> </li> </ul> </div> <div class="footer-column"> <h3>Services</h3> <ul> <li> <a href="https://oxfordglobal.com/in-person-services/"> In-Person Services </a> </li> <li> <a href="https://oxfordglobal.com/digital-marketing-services/"> Digital Marketing Services </a> </li> </ul> <h3>Upcoming Events</h3> <ul> <li> <a href="https://oxfordglobal.com/calendar/"> Event Calendar </a> </li> </ul> </div> <div class="footer-column"> <h3>Company</h3> <ul> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/about-us/"> About </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/vacancies/"> Vacancies </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/csr-policy/"> CSR Policy </a> </li> <li class="elementor-icon-list-item"> <a href="javascript:postMessage({type:'HS_DISPLAY_CALL_TO_ACTION',id:130207947529});"> Contact </a> </li> </ul> </div> <div class="footer-column"> <p> <a href="tel:+441865248455">+44 1865 248 455</a><br> <a href="mailto:help@oxfordglobal.com">help@oxfordglobal.com</a> </p> <p> <strong>Our UK Address:</strong><br> Godstow Court<br> Minns Business Park<br> Botley<br> Oxford, OX2 0JB </p> <p> <strong>Our US Address:</strong><br> 100 Cambridge Street<br> 14th Floor<br> Boston<br> MA 02114 </p> </div> </div> <div class="footer-bottom grid g-20"> <div class="span8 span12-sm span12-md flex flex-column g-10"> <div class="copyright"> © Oxford Global Marketing Ltd. 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