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-padding--horizontal"> <div class="layout-columns__main__content"> <ul class="content-tease__list"> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/video.aspx?id=1153" itemprop="url"> Immunotherapies to Treat Glioblastoma</a> </h3> <p itemprop="description"> <p>William T. Curry, MD, co-director of Mass General Neuroscience and director of Neurosurgical Oncology in the Department of Neurosurgery at Massachusetts General Hospital, discusses a four-center trial studying the use of poliovirus to treat malignant brain tumors.</p></p> <p class="content-tease__related"> <a href="/neuro/topic.aspx?id=1022" itemprop="relatedLink">Brain Tumor</a>, <a href="/research-and-innovation/topic.aspx?id=1114" itemprop="relatedLink">Gene and Cell Therapy</a>, <a href="/oncology/topic.aspx?id=1081" itemprop="relatedLink">Immunotherapy</a>, <a href="/oncology/topic.aspx?id=1061" itemprop="relatedLink">Neuro-Oncology</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1019" itemprop="relatedLink">Neurosurgery</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -video">Video</span> <time class="date" datetime="2021-05-19" itemprop="datePublished">May 19, 2021</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/oncology/article.aspx?id=1566" itemprop="url"> Revolutionizing Cancer Immunotherapy for Melanoma and Beyond</a> </h3> <p itemprop="description"> <p>Researchers at Massachusetts General Hospital won a Breakthrough Award to enhance personalized approaches to immunotherapy for metastatic melanoma.</p></p> <p class="content-tease__related"> <a href="/oncology/topic.aspx?id=1081" itemprop="relatedLink">Immunotherapy</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2024-04-09" itemprop="datePublished">April 9, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/journal.aspx?id=2588" itemprop="url"> Review: The Role of Antibody-Based Therapies in Neuro-Oncology</a> </h3> <p itemprop="description"> <p><span>Rishab Ramapriyan, William T. Curry, MD, Bryan D. Choi, MD, PhD, and colleagues describe the antibody-based therapies being used to treat glioblastoma and other central nervous system tumors, with special attention to the challenges of blood–brain barrier penetration and tumor-derived immunosuppression.</span></p></p> <p class="content-tease__related"> <a href="/neuro/topic.aspx?id=1022" itemprop="relatedLink">Brain Tumor</a>, <a href="/oncology/topic.aspx?id=1081" itemprop="relatedLink">Immunotherapy</a>, <a href="/oncology/topic.aspx?id=1061" itemprop="relatedLink">Neuro-Oncology</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1019" itemprop="relatedLink">Neurosurgery</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-02-16" itemprop="datePublished">February 16, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2546" itemprop="url"> Concurrent Immunosuppressive Therapy With Restart of Checkpoint Inhibitor Reduces Risk of Recurrent Immune-related Enterocolitis</a> </h3> <p itemprop="description"> <p><span>A retrospective study at Massachusetts General Hospital and two other centers found cancer patients who had an immune checkpoint inhibitor restarted after an episode of immune-related enterocolitis had significantly less risk of severe recurrent enterocolitis if they concurrently received infliximab or vedolizumab.</span></p></p> <p class="content-tease__related"> <a href="/digestive-health/topic.aspx?id=1040" itemprop="relatedLink">Bowel Disease</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/oncology/topic.aspx?id=1081" itemprop="relatedLink">Immunotherapy</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2023-11-07" itemprop="datePublished">November 7, 2023</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/urology/journal.aspx?id=2476" itemprop="url"> Review: Checkpoint Inhibitors and Other Immunotherapies in Urologic Cancer</a> </h3> <p itemprop="description"> <p><span>Aleksandra Walasek, MD, and Dimitar V. Zlatev, MD, discuss progress in immunotherapies for urologic cancers, showing checkpoint inhibitors are often first-line therapy, combination regimens are improving outcomes, and antibody–drug conjugates are becoming new options for dual-refractory bladder cancer.</span></p></p> <p class="content-tease__related"> <a href="/oncology/topic.aspx?id=1081" itemprop="relatedLink">Immunotherapy</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a>, <a href="/oncology/topic.aspx?id=1065" itemprop="relatedLink">Prostate Cancer</a>, <a href="/oncology/topic.aspx?id=1060" itemprop="relatedLink">Urologic Cancer</a>, <a href="/urology/specialty.aspx?id=1005" itemprop="relatedLink">Urology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2023-05-09" itemprop="datePublished">May 9, 2023</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/oncology/journal.aspx?id=2320" itemprop="url"> Activating CD4+ T Cells at Benign Nevi Might Prevent Melanoma</a> </h3> <p itemprop="description"> <p><span>Shadmehr Demehri, MD, PhD, Erik B. Schiferle, and colleagues determined benign nevi harbor CD4+ T cells that can be activated in situ to reject the nevus. If a novel therapy could block immunosuppressive regulatory T cells, CD4+ cells might prevent progression to melanoma in high-risk patients and enhance immunotherapy.</span></p></p> <p class="content-tease__related"> <a href="/oncology/topic.aspx?id=1081" itemprop="relatedLink">Immunotherapy</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2022-09-19" itemprop="datePublished">September 19, 2022</time> </p> </div> </li> </ui> <p class="fat-link__cta u-flush u-text-right"> <a class="fat-link -caret -large" href="https://advances.massgeneral.org/search.aspx?q=*&st=1&topic=immunotherapy&maxResults=15">View all Immunotherapy updates</a> </p> </div> </div> </section> <section class="-background--grey -padding--vertical -padding--horizontal"> <div class="content-container -width--wide -centered"> <h2 class="section-heading -centered">Mass General Cancer Center Contributors</h2> <ul class="profile-card__list" id="profile-cards"> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/areej_el_jawahri_advances.png, /assets/images/contributors/areej_el_jawahri_advances_2x.png 2x" src="/assets/images/contributors/areej_el_jawahri_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1553" itemprop="url">Areej R. El-Jawahri, MD</a> </h3> <p itemprop="jobTitle"> Hematologist, Mass General Cancer Center, Assistant in Medicine, Massachusetts General Hospital, Instructor in Medicine, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/oncology/journal.aspx?id=2522">Enasidenib Safe, Well Tolerated As Maintenance After Stem Cell Transplantation for IDH2-Mutated Myeloid Malignancies</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/areej_el_jawahri_advances.png, /assets/images/contributors/areej_el_jawahri_advances_2x.png 2x" src="/assets/images/contributors/areej_el_jawahri_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Chin-Lee Wu" itemprop="image" srcset="/assets/images/contributors/chin-lee_wu_advances.png, /assets/images/contributors/chin-lee_wu_advances_2x.png 2x" src="/assets/images/contributors/chin-lee_wu_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1188" itemprop="url">Chin-Lee Wu, MD, PhD</a> </h3> <p itemprop="jobTitle"> Director, Genitourinary Pathology Service, Massachusetts General Hospital and Mass General Cancer Center, Professor of Pathology, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/urology/journal.aspx?id=2632">Multiparametric MRI Is Often False-Negative for Clinically Significant Prostate Cancer</a> </p> </div> <p class="profile-card__image"> <img alt="Chin-Lee Wu" itemprop="image" srcset="/assets/images/contributors/chin-lee_wu_advances.png, /assets/images/contributors/chin-lee_wu_advances_2x.png 2x" src="/assets/images/contributors/chin-lee_wu_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Justin Gainor, MD" itemprop="image" srcset="/assets/images/contributors/justin_gainor_advances.png, /assets/images/contributors/justin_gainor_advances_2x.png 2x" src="/assets/images/contributors/justin_gainor_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=2036" itemprop="url">Justin Gainor, MD</a> </h3> <p itemprop="jobTitle"> Director, Center for Thoracic Cancers Program, Director of Targeted Immunotherapy, Mass General Cancer Center, Associate Professor of Medicine, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/oncology/journal.aspx?id=2610">Molecular Features Identified That Predict Response to Checkpoint Inhibitors in NSCLC</a> </p> </div> <p class="profile-card__image"> <img alt="Justin Gainor, MD" itemprop="image" srcset="/assets/images/contributors/justin_gainor_advances.png, /assets/images/contributors/justin_gainor_advances_2x.png 2x" src="/assets/images/contributors/justin_gainor_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Dr. Dougan" itemprop="image" srcset="/assets/images/contributors/michael_dougan_advances.png, /assets/images/contributors/michael_dougan_advances_2x.png 2x" src="/assets/images/contributors/michael_dougan_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1517" itemprop="url">Michael L. Dougan, MD, PhD</a> </h3> <p itemprop="jobTitle"> Physician, Division of Gastroenterology, Massachusetts General Hospital, Director, GI Center for Cancer Complications, Mass General Cancer Center, Preclinical Education Group Leader, Associate Professor of Medicine, Harvard Medical School </p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/digestive-health/journal.aspx?id=2637">Case Series: Tofacitinib Is Effective in Treating Refractory Immune Checkpoint Inhibitor Hepatitis</a> </p> </div> <p class="profile-card__image"> <img alt="Dr. Dougan" itemprop="image" srcset="/assets/images/contributors/michael_dougan_advances.png, /assets/images/contributors/michael_dougan_advances_2x.png 2x" src="/assets/images/contributors/michael_dougan_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="William Curry, MD" itemprop="image" srcset="/assets/images/contributors/William_Curry_17181_advances.png, /assets/images/contributors/William_Curry_17181_advances_2x.png 2x" src="/assets/images/contributors/William_Curry_17181_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1118" itemprop="url">William T. Curry, MD</a> </h3> <p itemprop="jobTitle"> Co-Director, Mass General Neuroscience , Director of Neurosurgical Oncology, Massachusetts General Hospital, Adeline Rose Wydotis Professor of Neurosurgery, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/journal.aspx?id=2588">Review: The Role of Antibody-Based Therapies in Neuro-Oncology</a> </p> </div> <p class="profile-card__image"> <img alt="William Curry, MD" itemprop="image" srcset="/assets/images/contributors/William_Curry_17181_advances.png, /assets/images/contributors/William_Curry_17181_advances_2x.png 2x" src="/assets/images/contributors/William_Curry_17181_advances.png"> </p> </li> </ul> <p class="fat-link__wrapper u-text-centered"> <button class="fat-link -plus -large" data-module="view-cards" data-target="#profile-cards" data-show="4">Mass General Cancer Center Contributors</button> </p> </div> </section> <div class="content-container -width--xwide -centered 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