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Gene and Cell Therapy - Mass General Advances in Motion
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-padding--horizontal -padding--vertical -background--blue"> <div class="layout-columns__sidebar__content"> <h1 class="sidebar-heading"> <span class="sidebar-heading__subheading">Topic</span>Gene and Cell Therapy </h1> </div> </div> <div class="layout-columns__main -padding--vertical -padding--horizontal"> <div class="layout-columns__main__content"> <ul class="content-tease__list"> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/video.aspx?id=1113" itemprop="url"> Collaboration in Developing New Cell Therapy</a> </h3> <p itemprop="description"> <p>In this video, Bob S. Carter, MD, PhD, Kwang-Soo Kim, PhD, Todd M. Herrington, MD, PhD, and Jeffrey S. Schweitzer, MD, PhD, discuss their cross-disciplinary and multi-institutional collaboration to develop this new therapy.</p></p> <p class="content-tease__related"> <a href="/research-and-innovation/topic.aspx?id=1114" itemprop="relatedLink">Gene and Cell Therapy</a>, <a href="/neuro/topic.aspx?id=1024" itemprop="relatedLink">Neurodegenerative Disease</a>, <a href="/neuro/topic.aspx?id=1018" itemprop="relatedLink">Neurology</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1019" itemprop="relatedLink">Neurosurgery</a> </p> <p class="content-metadata"> <span class="content-metadata__media -video">Video</span> <time class="date" datetime="2020-05-13" itemprop="datePublished">May 13, 2020</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/ophthalmology/journal.aspx?id=2035" itemprop="url"> Gene Therapy Reverses Degeneration of the Retinal Pigment Epithelium in Preclinical Models</a> </h3> <p itemprop="description"> <p>Gene therapy with Nrf2—a master transcription factor—preserves the retinal pigment epithelium in mouse models of retinitis pigmentosa, David M. Wu, MD, PhD, of the Department of Ophthalmology, and colleagues observed.</p></p> <p class="content-tease__related"> <a href="/research-and-innovation/topic.aspx?id=1114" itemprop="relatedLink">Gene and Cell Therapy</a>, <a href="/ophthalmology/specialty.aspx?id=1014" itemprop="relatedLink">Ophthalmology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2021-08-27" itemprop="datePublished">August 27, 2021</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/oncology/journal.aspx?id=2347" itemprop="url"> Enhanced Interferon Signaling May Improve CAR T-cell Immunotherapy for Solid Tumors</a> </h3> <p itemprop="description"> <p><span>Marcela V. Maus, MD, PhD, Rebecca C. Larson, PhD, and colleagues found that loss of genes in the interferon-gamma receptor signaling pathway is a mechanism of resistance to chimeric antigen receptor (CAR) T-cell therapy, suggesting a way to improve CAR T-cell treatment design for solid tumors.</span></p></p> <p class="content-tease__related"> <a href="/oncology/topic.aspx?id=1100" itemprop="relatedLink">CAR T-cell Therapy</a>, <a href="/research-and-innovation/topic.aspx?id=1114" itemprop="relatedLink">Gene and Cell Therapy</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2022-11-09" itemprop="datePublished">November 9, 2022</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/research-and-innovation/q-a.aspx?id=1031" itemprop="url"> Innovations in Hearing and Vision Restoration Through Gene Therapy</a> </h3> <p itemprop="description"> <p>Artur A. Indzhykulian, MD, PhD, is advancing gene therapies for sensory disorders like Usher syndrome, exploring innovative approaches to restore hearing, balance, and vision through cutting-edge research and cross-disciplinary collaboration.</p></p> <p class="content-tease__related"> <a href="/research-and-innovation/topic.aspx?id=1114" itemprop="relatedLink">Gene and Cell Therapy</a>, <a href="/otolaryngology/topic.aspx?id=1113" itemprop="relatedLink">Hearing Loss</a>, <a href="/otolaryngology/specialty.aspx?id=1016" itemprop="relatedLink">Otolaryngology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -qa">Q & A</span> <time class="date" datetime="2024-11-05" itemprop="datePublished">November 5, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/journal.aspx?id=2644" itemprop="url"> Hematopoietic Stem-Cell Gene Therapy Restores White Matter Microvascular Function in Cerebral Adrenoleukodystrophy</a> </h3> <p itemprop="description"> <p>Arne Lauer, MD, Patricia L. Musolino, MD, PhD, and colleagues found that <em>ABCD1</em> gene therapy with autologous hematopoietic stem cells halts the progression of cerebral adrenoleukodystrophy at least in part because it improves microvascular circulation of the entire cerebral white matter.</p></p> <p class="content-tease__related"> <a href="/research-and-innovation/topic.aspx?id=1114" itemprop="relatedLink">Gene and Cell Therapy</a>, <a href="/neuro/topic.aspx?id=1024" itemprop="relatedLink">Neurodegenerative Disease</a>, <a href="/neuro/topic.aspx?id=1018" itemprop="relatedLink">Neurology</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-08-26" itemprop="datePublished">August 26, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/journal.aspx?id=2640" itemprop="url"> Case Series: Intraventricular Infusion of Dual-targeting CAR T-Cells for Glioblastoma</a> </h3> <p itemprop="description"> <p>Massachusetts General Hospital researchers showed rapid, dramatic radiographic responses in three patients with glioblastoma who received intraventricular infusion of CAR T-cells that targeted both EGFR variant III and wild-type EGFR. In two of the patients, however, the effects were transient.</p></p> <p class="content-tease__related"> <a href="/neuro/topic.aspx?id=1022" itemprop="relatedLink">Brain Tumor</a>, <a href="/research-and-innovation/topic.aspx?id=1114" itemprop="relatedLink">Gene and Cell Therapy</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1019" itemprop="relatedLink">Neurosurgery</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-07-31" itemprop="datePublished">July 31, 2024</time> </p> </div> </li> </ui> <p class="fat-link__cta u-flush u-text-right"> <a class="fat-link -caret -large" href="https://advances.massgeneral.org/search.aspx?q=*&st=1&topic=gene%20and%20cell%20therapy&maxResults=15">View all Gene and Cell Therapy updates</a> </p> </div> </div> </section> <section class="-background--grey -padding--vertical -padding--horizontal"> <div class="content-container -width--wide -centered"> <h2 class="section-heading -centered">Gene and Cell Therapy Contributors</h2> <ul class="profile-card__list" id="profile-cards"> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/Bob_Carter_20120_advances.png, /assets/images/contributors/Bob_Carter_20120_advances_2x.png 2x" src="/assets/images/contributors/Bob_Carter_20120_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1106" itemprop="url">Bob S. Carter, MD, PhD</a> </h3> <p itemprop="jobTitle"> Chief, Neurosurgery Service</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/journal.aspx?id=2532">Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/Bob_Carter_20120_advances.png, /assets/images/contributors/Bob_Carter_20120_advances_2x.png 2x" src="/assets/images/contributors/Bob_Carter_20120_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Jeffrey Schweitzer, MD, PhD" itemprop="image" srcset="/assets/images/contributors/Jeffrey_Schweitzer_20345_advances.png, /assets/images/contributors/Jeffrey_Schweitzer_20345_advances_2x.png 2x" src="/assets/images/contributors/Jeffrey_Schweitzer_20345_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1112" itemprop="url">Jeffrey S. Schweitzer, MD, PhD</a> </h3> <p itemprop="jobTitle"> Neurosurgeon, Department of Neurosurgery, Massachusetts General Hospital, Assistant Professor of Neurosurgery, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/q-a.aspx?id=1024">Essential Tremor Treatment Advancements Using MRI-guided Focused Ultrasound: Q&A With Jeffrey S. Schweitzer, MD, PhD</a> </p> </div> <p class="profile-card__image"> <img alt="Jeffrey Schweitzer, MD, PhD" itemprop="image" srcset="/assets/images/contributors/Jeffrey_Schweitzer_20345_advances.png, /assets/images/contributors/Jeffrey_Schweitzer_20345_advances_2x.png 2x" src="/assets/images/contributors/Jeffrey_Schweitzer_20345_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Jeremy Slade Abramson" itemprop="image" srcset="/assets/images/contributors/jeremy_abramson_adavces.png, /assets/images/contributors/jeremy_abramson_adavces_2x.png 2x" src="/assets/images/contributors/jeremy_abramson_adavces.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1902" itemprop="url">Jeremy Slade Abramson, MD</a> </h3> <p itemprop="jobTitle"> Director, Jon and JoAnn Hagler Center for Lymphoma, Mass General Cancer Center, Associate Professor of Medicine, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/oncology/journal.aspx?id=2468">Neutropenia-driven Approach to G-CSF Use May Be Feasible With CAR T-Cell Therapy</a> </p> </div> <p class="profile-card__image"> <img alt="Jeremy Slade Abramson" itemprop="image" srcset="/assets/images/contributors/jeremy_abramson_adavces.png, /assets/images/contributors/jeremy_abramson_adavces_2x.png 2x" src="/assets/images/contributors/jeremy_abramson_adavces.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/luk_vandenberghe2_advances.png, /assets/images/contributors/luk_vandenberghe2_advances_2x.png 2x" src="/assets/images/contributors/luk_vandenberghe2_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1916" itemprop="url">Luk Vandenberghe, PhD</a> </h3> <p itemprop="jobTitle"> Associate Professor of Ophthalmology, Harvard Medical School, Grousbeck Family Chair in Gene Therapy and Director of the Grousbeck Gene Therapy Center, Mass Eye and Ear</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/research-and-innovation/article-external.aspx?id=1100">Developing a Gene-based Vaccine Candidate for COVID-19</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/luk_vandenberghe2_advances.png, /assets/images/contributors/luk_vandenberghe2_advances_2x.png 2x" src="/assets/images/contributors/luk_vandenberghe2_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Marcela Maus, MD, PhD, Profile Image" itemprop="image" srcset="/assets/images/contributors/marcella_maus_advances.png, /assets/images/contributors/marcella_maus_advances_2x.png 2x" src="/assets/images/contributors/marcella_maus_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1448" itemprop="url">Marcela V. Maus, MD, PhD</a> </h3> <p itemprop="jobTitle"> Director, Cellular Immunotherapy Program, Mass General Cancer Center, Associate Professor of Medicine, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/journal.aspx?id=2640">Case Series: Intraventricular Infusion of Dual-targeting CAR T-Cells for Glioblastoma</a> </p> </div> <p class="profile-card__image"> <img alt="Marcela Maus, MD, PhD, Profile Image" itemprop="image" srcset="/assets/images/contributors/marcella_maus_advances.png, /assets/images/contributors/marcella_maus_advances_2x.png 2x" src="/assets/images/contributors/marcella_maus_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Merit Cudkowicz" itemprop="image" srcset="/assets/images/contributors/merit_cudkowicz_advances.png, /assets/images/contributors/merit_cudkowicz_advances_2x.png 2x" src="/assets/images/contributors/merit_cudkowicz_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1219" itemprop="url">Merit Ester Cudkowicz, MD, MSc</a> </h3> <p itemprop="jobTitle"> Chief, Neurology Service, Director of the Sean M. Healey & AMG Center for ALS at Mass General, Director of Neurological Clinical Research Institute and the Jilieane Dorn Professor of Neurology, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/article.aspx?id=1521">ALS Therapy Research and Development: Insights from Merit Cudkowicz, MD, MSc</a> </p> </div> <p class="profile-card__image"> <img alt="Merit Cudkowicz" itemprop="image" srcset="/assets/images/contributors/merit_cudkowicz_advances.png, /assets/images/contributors/merit_cudkowicz_advances_2x.png 2x" src="/assets/images/contributors/merit_cudkowicz_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Priscilla K. Brastianos, MD" itemprop="image" srcset="/assets/images/contributors/priscilla_brastianos_advances.png, /assets/images/contributors/priscilla_brastianos_advances_2x.png 2x" src="/assets/images/contributors/priscilla_brastianos_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1405" itemprop="url">Priscilla K. Brastianos, MD</a> </h3> <p itemprop="jobTitle"> Director, Central Nervous System Metastasis Center, Mass General Cancer Center, Associate Professor of Medicine, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/oncology/article.aspx?id=1578">ASCO 2024 Meeting Highlights</a> </p> </div> <p class="profile-card__image"> <img alt="Priscilla K. Brastianos, MD" itemprop="image" srcset="/assets/images/contributors/priscilla_brastianos_advances.png, /assets/images/contributors/priscilla_brastianos_advances_2x.png 2x" src="/assets/images/contributors/priscilla_brastianos_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Dr. Richardson" itemprop="image" srcset="/assets/images/contributors/robert-richardson_advances.png, /assets/images/contributors/robert-richardson_advances_2x.png 2x" src="/assets/images/contributors/robert-richardson_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1421" itemprop="url">Robert (Mark) Richardson, MD, PhD</a> </h3> <p itemprop="jobTitle"> Director of Functional Neurosurgery, Massachusetts General Hospital</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/journal.aspx?id=2526">Intracranial Stereo-EEG Resolves Discordant Clinical vs. Neuroimaging Findings in Patient With Tonic鈥揅lonic Seizures</a> </p> </div> <p class="profile-card__image"> <img alt="Dr. Richardson" itemprop="image" srcset="/assets/images/contributors/robert-richardson_advances.png, /assets/images/contributors/robert-richardson_advances_2x.png 2x" src="/assets/images/contributors/robert-richardson_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/todd_harrington_advances.png, /assets/images/contributors/todd_harrington_advances_2x.png 2x" src="/assets/images/contributors/todd_harrington_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1641" itemprop="url">Todd M. Herrington, MD, PhD</a> </h3> <p itemprop="jobTitle"> Director, Deep Brain Stimulation Program, Massachusetts General Hospital</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/journal.aspx?id=2532">Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/todd_harrington_advances.png, /assets/images/contributors/todd_harrington_advances_2x.png 2x" src="/assets/images/contributors/todd_harrington_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="William Curry, MD" itemprop="image" srcset="/assets/images/contributors/William_Curry_17181_advances.png, /assets/images/contributors/William_Curry_17181_advances_2x.png 2x" src="/assets/images/contributors/William_Curry_17181_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1118" itemprop="url">William T. Curry, MD</a> </h3> <p itemprop="jobTitle"> Co-Director, Mass General Neuroscience , Director of Neurosurgical Oncology, Massachusetts General Hospital, Adeline Rose Wydotis Professor of Neurosurgery, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/journal.aspx?id=2588">Review: The Role of Antibody-Based Therapies in Neuro-Oncology</a> </p> </div> <p class="profile-card__image"> <img alt="William Curry, MD" itemprop="image" srcset="/assets/images/contributors/William_Curry_17181_advances.png, /assets/images/contributors/William_Curry_17181_advances_2x.png 2x" src="/assets/images/contributors/William_Curry_17181_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/Yquiroz_advances.png, /assets/images/contributors/Yquiroz_advances_2x.png 2x" src="/assets/images/contributors/Yquiroz_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1135" itemprop="url">Yakeel T. 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