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Tumor: surgical treatment</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Pancreatic carcinoma is a devastating disease. Untreated 5-year survival is 0%. The only possibility of being cured is given by surgical removal of the tumor. Pancreatoduodenectomy previously involved high morbidity and mortality rates... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16204328" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Pancreatic carcinoma is a devastating disease. Untreated 5-year survival is 0%. The only possibility of being cured is given by surgical removal of the tumor. Pancreatoduodenectomy previously involved high morbidity and mortality rates until it was postulated that palliation gave better results. Today, morbidity and mortality rates have been decreased to an acceptable level, mortality rates in specialized centers being under 5%. Prognostic factors determining survival were found to be the size of the tumor, grade, lymph node involvement and stage. In order to be able to compare results of the different centers, standardization of the surgical technique is mandatory. It is unanimously accepted that in order to improve survival in pancreatic carcinoma, the radicality of the surgical procedure should be increased to include lymphadenectomy. Postoperative adjuvant therapy could also be a determinant factor. 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Tumor: surgical treatment","created_at":"2015-09-26T12:10:00.358-07:00","owner_id":35314243,"url":"https://www.academia.edu/16204328/Pancreatic_head_mass_how_can_we_treat_it_Tumor_surgical_treatment","slug":"Pancreatic_head_mass_how_can_we_treat_it_Tumor_surgical_treatment","dom_id":"work_16204328","summary":"Pancreatic carcinoma is a devastating disease. Untreated 5-year survival is 0%. The only possibility of being cured is given by surgical removal of the tumor. Pancreatoduodenectomy previously involved high morbidity and mortality rates until it was postulated that palliation gave better results. Today, morbidity and mortality rates have been decreased to an acceptable level, mortality rates in specialized centers being under 5%. Prognostic factors determining survival were found to be the size of the tumor, grade, lymph node involvement and stage. In order to be able to compare results of the different centers, standardization of the surgical technique is mandatory. It is unanimously accepted that in order to improve survival in pancreatic carcinoma, the radicality of the surgical procedure should be increased to include lymphadenectomy. Postoperative adjuvant therapy could also be a determinant factor. Prospective randomized clinical trials will give an answer to these still unansw...","publication":"JOP : Journal of the pancreas","publication_with_fallback":"JOP : Journal of the pancreas","downloadable_attachments":[{"id":42635762,"asset_id":16204328,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42635762/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42635762/200009_spe_18-libre.pdf?1455342890=\u0026response-content-disposition=attachment%3B+filename%3DPancreatic_head_mass_how_can_we_treat_it.pdf\u0026Expires=1740541144\u0026Signature=SkrU7M4~JJ5CWcqh3WokAtVxf2JGA8RtGMzXi4c~ArXZcuWGdQQ9nOxuETDUAh38lpHl4zJrs~9BQkIMzNn1NHKhda-JocEiPwqu5sGDDBMJ70Ox-TWIxLBg~VuPdD-3Veo9-UMxvxkFyxFIhnNp190aXUQfncl9o0fC-sdbLwyW-nh807Fb~2662z3Sggj87nbJen3q7rRQWK3JXnC6DGx~6iVSLaQinbeUnD927KLZgQuEGvYUohbW4YXnBaVyVOW~KNIK-wHBLH4WLWCWSCmafjn76voRmh4wSZFUduGM55ehqSkh9CGSgZzw-EemQKOM-9UPBP2umxmC~1FNJQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42635762/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42635762/mini_magick20190217-8880-158hfwe.png?1550424491"}],"downloadable_attachments_with_full_thumbnails":[{"id":42635762,"asset_id":16204328,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42635762/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42635762/200009_spe_18-libre.pdf?1455342890=\u0026response-content-disposition=attachment%3B+filename%3DPancreatic_head_mass_how_can_we_treat_it.pdf\u0026Expires=1740541145\u0026Signature=HeOXmKb4xW5OhfQPtADmTxSPf7ByWSDOKabGnJji9Z2hYQOZI7Py~kkwfOiiLK5KiL63zfmpR2MLqQTw2F85oV~0zorLN1nY9d1ulelpkBXuEQ7G1YzEcyu52hr518wYn5uRM44kG3bsFj7gbMzbn3USOyFxb2I-dA4VjdZYhAh7j8gDuerYToj4RZnjLAizi-pVHe6S~bgEXG9glNCZOPbK-Ld5e0CZh1KJB3cnpTNIR0d-eD2E1OXEIqagbKTYUqG9FD9FLNVGybgcm6JIwZt-WfPE4VkKz1-d9vg-p9PKfJY2tu1m8MFIiWfjQZ9RHwRnF2v~q-fIJ5z6rTLKcg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42635762/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42635762/mini_magick20190217-8880-158hfwe.png?1550424491"}],"has_pdf":true,"has_fulltext":true,"page_count":7,"ordered_authors":[{"id":35314243,"first_name":"T.","last_name":"Winternitz","domain_name":"sote","page_name":"TWinternitz","display_name":"T. Winternitz","profile_url":"https://sote.academia.edu/TWinternitz","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences","nofollow":true},{"id":561974,"name":"SURGICAL TECHNIQUE","url":"https://www.academia.edu/Documents/in/SURGICAL_TECHNIQUE","nofollow":true},{"id":596484,"name":"Randomized Clinical Trial","url":"https://www.academia.edu/Documents/in/Randomized_Clinical_Trial","nofollow":true},{"id":911025,"name":"Lymph Node","url":"https://www.academia.edu/Documents/in/Lymph_Node","nofollow":true},{"id":995219,"name":"ADJUVANT THERAPY","url":"https://www.academia.edu/Documents/in/ADJUVANT_THERAPY"},{"id":1289042,"name":"Pancreaticoduodenectomy","url":"https://www.academia.edu/Documents/in/Pancreaticoduodenectomy"},{"id":1680434,"name":"Mortality rate","url":"https://www.academia.edu/Documents/in/Mortality_rate"},{"id":2222636,"name":"Surgical Treatment","url":"https://www.academia.edu/Documents/in/Surgical_Treatment"}],"publication_year":2000,"publication_year_with_fallback":2000,"paper_rank":null,"all_time_views":30,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15449200 coauthored" data-work_id="15449200" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15449200/Functional_Evaluation_of_Multidrug_Resistance_Transporter_Activity_in_Surgical_Samples_of_Solid_Tumors">Functional Evaluation of Multidrug Resistance Transporter Activity in Surgical Samples of Solid Tumors</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Determination of multidrug resistance (MDR) activity of tumor cells could provide important information for the personalized therapy of cancer patients. The functional calcein assay (MultiDrug Quant Assay™, Solvo Biotechnology, Budaörs,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_15449200" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Determination of multidrug resistance (MDR) activity of tumor cells could provide important information for the personalized therapy of cancer patients. The functional calcein assay (MultiDrug Quant Assay™, Solvo Biotechnology, Budaörs, Hungary) has been proven to be clinically valuable in hematological malignancies by determining the transporter activity of MDR protein 1 (MDR1, ATP-binding cassette protein [ABC] B1, P-glycoprotein-170) and MDR-related protein 1 (MRP1, ABCC1). In this study, we evaluated if the same functional test was adaptable for the analysis of MDR activity in solid tumors. For this purpose, tissue specimens of human colorectal cancer samples were subjected to limited enzymatic digestion by collagenase to provide a single-cell suspension; dead cells were excluded by 7-aminoactinomycin D staining, and epithelial cancer cells were detected by Cy5-conjugated anti-BerEP4 monoclonal antibody. The transporter functions of MDR1 and MRP1 in viable epithelial cells were assessed by flow cytometry detecting the intracellular accumulation of calcein dye after exposing cells to various MDR inhibitors. Collagenase disintegration preserved the MDR activity and the antigenicity of tumor cells. Thus using the extended calcein assay provided sufficient viable and functionally active tumor cells from surgical biopsies to determine the functional MDR activity. In conclusion, the newly described modified calcein assay may be applicable for evaluating the MDR phenotype in solid tissue specimens from colorectal forceps biopsy to surgical samples.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15449200" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ec0b580ac409f91e28c5feec153f2390" rel="nofollow" data-download="{"attachment_id":43183750,"asset_id":15449200,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43183750/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34592409" href="https://sote.academia.edu/Istv%C3%A1nPet%C3%A1k">István Peták</a><script data-card-contents-for-user="34592409" type="text/json">{"id":34592409,"first_name":"István","last_name":"Peták","domain_name":"sote","page_name":"IstvánPeták","display_name":"István Peták","profile_url":"https://sote.academia.edu/Istv%C3%A1nPet%C3%A1k","photo":"https://0.academia-photos.com/34592409/10106969/11276707/s65_istv_n.pet_k.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-15449200">+1</span><div class="hidden js-additional-users-15449200"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://sote.academia.edu/BTihanyi">Balázs Tihanyi</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-15449200'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-15449200').html(); 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The functional calcein assay (MultiDrug Quant Assay™, Solvo Biotechnology, Budaörs, Hungary) has been proven to be clinically valuable in hematological malignancies by determining the transporter activity of MDR protein 1 (MDR1, ATP-binding cassette protein [ABC] B1, P-glycoprotein-170) and MDR-related protein 1 (MRP1, ABCC1). In this study, we evaluated if the same functional test was adaptable for the analysis of MDR activity in solid tumors. For this purpose, tissue specimens of human colorectal cancer samples were subjected to limited enzymatic digestion by collagenase to provide a single-cell suspension; dead cells were excluded by 7-aminoactinomycin D staining, and epithelial cancer cells were detected by Cy5-conjugated anti-BerEP4 monoclonal antibody. The transporter functions of MDR1 and MRP1 in viable epithelial cells were assessed by flow cytometry detecting the intracellular accumulation of calcein dye after exposing cells to various MDR inhibitors. Collagenase disintegration preserved the MDR activity and the antigenicity of tumor cells. Thus using the extended calcein assay provided sufficient viable and functionally active tumor cells from surgical biopsies to determine the functional MDR activity. In conclusion, the newly described modified calcein assay may be applicable for evaluating the MDR phenotype in solid tissue specimens from colorectal forceps biopsy to surgical samples.","publication":"ASSAY and Drug Development Technologies","publication_with_fallback":"ASSAY and Drug Development 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u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_109852529" data-work_id="109852529" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/109852529/Intraductal_Tubulopapillary_Neoplasms_of_the_Pancreas_Distinct_From_Pancreatic_Intraepithelial_Neoplasia_and_Intraductal_Papillary_Mucinous_Neoplasms">Intraductal Tubulopapillary Neoplasms of the Pancreas Distinct From Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We report a young boy patient who underwent laparoscopic assisted enucleation with placement of nasopancreatic stent. The patient was 10 years old boy. He admitted to our hospital because of an abdominal pain after hitting his abdomen... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_109852529" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We report a young boy patient who underwent laparoscopic assisted enucleation with placement of nasopancreatic stent. The patient was 10 years old boy. He admitted to our hospital because of an abdominal pain after hitting his abdomen with soccer ball. His blood examination indicated an acute pancreatitis. And he had a 40 mm tumor close to the main pancreatic duct (MPD) in the pancreatic neck and body on enhanced-CT. The patient and his parents chose the laparoscopic enucleation. We placed a nasopancreatic stent after general anesthesia due to identify the pancreatic duct and avoid the injury. We could performed the laparoscopic assisted enucleation safely. After pancreatography, we changed from nasopancreatic stent to short pancreatic stent. The surgical time including enscopic procedure was 480 min. The blood loss was 90 ml. His POF rate was Grade A. His oral intake was started on postoperative day (POD) 4. He was discharged uneventfully on POD 21. The short pancreatic stent was removed POD 40. Intraoperative nasopancreatic stent is useful for enucleation, especially the tumor is closed to the main pancreatic duct.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/109852529" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="21ff5dcf404e1c9b3f7d9eb505108dc4" rel="nofollow" data-download="{"attachment_id":107851882,"asset_id":109852529,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/107851882/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34686687" href="https://sote.academia.edu/BTihanyi">Balázs Tihanyi</a><script data-card-contents-for-user="34686687" type="text/json">{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs Tihanyi","profile_url":"https://sote.academia.edu/BTihanyi","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_109852529 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="109852529"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 109852529, container: ".js-paper-rank-work_109852529", }); 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The patient was 10 years old boy. He admitted to our hospital because of an abdominal pain after hitting his abdomen with soccer ball. His blood examination indicated an acute pancreatitis. And he had a 40 mm tumor close to the main pancreatic duct (MPD) in the pancreatic neck and body on enhanced-CT. The patient and his parents chose the laparoscopic enucleation. We placed a nasopancreatic stent after general anesthesia due to identify the pancreatic duct and avoid the injury. We could performed the laparoscopic assisted enucleation safely. After pancreatography, we changed from nasopancreatic stent to short pancreatic stent. The surgical time including enscopic procedure was 480 min. The blood loss was 90 ml. His POF rate was Grade A. His oral intake was started on postoperative day (POD) 4. He was discharged uneventfully on POD 21. The short pancreatic stent was removed POD 40. Intraoperative nasopancreatic stent is useful for enucleation, especially the tumor is closed to the main pancreatic duct.","publication":"American Journal of Surgical Pathology","publication_with_fallback":"American Journal of Surgical Pathology","downloadable_attachments":[{"id":107851882,"asset_id":109852529,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/107851882/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/107851882/j.pan.2016.06.49920231126-1-zj3cyx-libre.pdf?1701001900=\u0026response-content-disposition=attachment%3B+filename%3DIntraductal_Tubulopapillary_Neoplasms_of.pdf\u0026Expires=1740541145\u0026Signature=HSdXxVpPjCQVkci4sH7lRGhVwFli6d7gdj52icHG8bGN6JqAqHVSgE66zuIODLxV80TP3OdDW~kAJuJ3AGDR0ql8zfP0li5RTblCACBShKsR3PKuPfGAXyE3QAl4xysmM0mAf35GvnHnl~adKSWjQnZ27T74qfjB7ds9bv9ZuIEVu9fI9xXn9r-t0QZons0yPxRFT3SmSMUAUophy4TP4gdXFVVOl0K1pn-Yi63mkmWhIBBuduZ0Xmhrq4YNOQ-6aSUCuFn7Npa-vVkrAHfiLYm0Ch7oau6AdsNT8wcepvFAYeT21I2-p5AFZiFhxIHKfWMk9v7dBN8VHgUAsE~rxA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/107851882/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/107851882/mini_magick20231126-1-96t09f.png?1701001880"}],"downloadable_attachments_with_full_thumbnails":[{"id":107851882,"asset_id":109852529,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/107851882/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/107851882/j.pan.2016.06.49920231126-1-zj3cyx-libre.pdf?1701001900=\u0026response-content-disposition=attachment%3B+filename%3DIntraductal_Tubulopapillary_Neoplasms_of.pdf\u0026Expires=1740541145\u0026Signature=HSdXxVpPjCQVkci4sH7lRGhVwFli6d7gdj52icHG8bGN6JqAqHVSgE66zuIODLxV80TP3OdDW~kAJuJ3AGDR0ql8zfP0li5RTblCACBShKsR3PKuPfGAXyE3QAl4xysmM0mAf35GvnHnl~adKSWjQnZ27T74qfjB7ds9bv9ZuIEVu9fI9xXn9r-t0QZons0yPxRFT3SmSMUAUophy4TP4gdXFVVOl0K1pn-Yi63mkmWhIBBuduZ0Xmhrq4YNOQ-6aSUCuFn7Npa-vVkrAHfiLYm0Ch7oau6AdsNT8wcepvFAYeT21I2-p5AFZiFhxIHKfWMk9v7dBN8VHgUAsE~rxA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/107851882/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/107851882/mini_magick20231126-1-96t09f.png?1701001880"}],"has_pdf":true,"has_fulltext":true,"page_count":1,"ordered_authors":[{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs 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Atypia","url":"https://www.academia.edu/Documents/in/Nuclear_Atypia"},{"id":2482159,"name":"DNA mutational analysis","url":"https://www.academia.edu/Documents/in/DNA_mutational_analysis"},{"id":3521397,"name":"Pancreatic neoplasms","url":"https://www.academia.edu/Documents/in/Pancreatic_neoplasms"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"publication_year":2009,"publication_year_with_fallback":2009,"paper_rank":null,"all_time_views":0,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_109852637" data-work_id="109852637" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/109852637/Collected_series_of_resected_intraductal_papillary_mucinous_tumours_IPMTs_of_the_pancreas_and_correlation_between_the_mucin_expression_profile_and_the_malignant_potential">Collected series of resected intraductal papillary mucinous tumours (IPMTs) of the pancreas and correlation between the mucin expression profile and the malignant potential</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Results: Of 291 PDAC patients 144 (49.4%) had cachexia at presentation (Cþ). Ca 19.9 values and the rate of jaundice (43.7% vs 40%;p¼0.5) at onset were similar in Cþ and C-. Cþ patients more frequently reported abdominal pain before... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_109852637" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Results: Of 291 PDAC patients 144 (49.4%) had cachexia at presentation (Cþ). Ca 19.9 values and the rate of jaundice (43.7% vs 40%;p¼0.5) at onset were similar in Cþ and C-. Cþ patients more frequently reported abdominal pain before diagnosis (56.4% vs 40.8% p¼0.004) and had longer diagnostic delay (4.8 vs 2.2 months; p<0.005). Age at diagnosis, and rate of diabetics were similar in Cþ and C-patients, but Cþ were more frequently male (61.1% vs 47.6%) and overweight (mean BMI 28.6 vs 25.9 p¼0.0001). Tumor site, grading and size were similar, but Cþ patients were more frequently metastatic at diagnosis (44.4% vs 32.6%; p¼0.004). Survival probability was lower, yet not significantly, in Cþ patients (7 vs 11 months; p¼0.84). Conclusion: Weight loss resulting in cachexia is an onset symptom of some 50% PDAC patients, more frequently observed in male and overweight subjects. Cachexia is associated with abdominal pain and longer diagnostic delay, and with a higher rate of metastatic disease at diagnosis, which might have an impact on outcome.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/109852637" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="876d723838a19cded3e71cc855341897" rel="nofollow" data-download="{"attachment_id":107851886,"asset_id":109852637,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/107851886/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34686687" href="https://sote.academia.edu/BTihanyi">Balázs Tihanyi</a><script data-card-contents-for-user="34686687" type="text/json">{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs Tihanyi","profile_url":"https://sote.academia.edu/BTihanyi","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_109852637 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="109852637"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 109852637, container: ".js-paper-rank-work_109852637", }); 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Ca 19.9 values and the rate of jaundice (43.7% vs 40%;p¼0.5) at onset were similar in Cþ and C-. Cþ patients more frequently reported abdominal pain before diagnosis (56.4% vs 40.8% p¼0.004) and had longer diagnostic delay (4.8 vs 2.2 months; p\u003c0.005). Age at diagnosis, and rate of diabetics were similar in Cþ and C-patients, but Cþ were more frequently male (61.1% vs 47.6%) and overweight (mean BMI 28.6 vs 25.9 p¼0.0001). Tumor site, grading and size were similar, but Cþ patients were more frequently metastatic at diagnosis (44.4% vs 32.6%; p¼0.004). Survival probability was lower, yet not significantly, in Cþ patients (7 vs 11 months; p¼0.84). Conclusion: Weight loss resulting in cachexia is an onset symptom of some 50% PDAC patients, more frequently observed in male and overweight subjects. Cachexia is associated with abdominal pain and longer diagnostic delay, and with a higher rate of metastatic disease at diagnosis, which might have an impact on outcome.","publication":"Pancreatology","publication_with_fallback":"Pancreatology","downloadable_attachments":[{"id":107851886,"asset_id":109852637,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/107851886/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/107851886/j.pan.2013.04.27720231126-1-ztd0ej-libre.pdf?1701001900=\u0026response-content-disposition=attachment%3B+filename%3DCollected_series_of_resected_intraductal.pdf\u0026Expires=1740541145\u0026Signature=a2yirGrC5~9kbWRiXpW98YggS59gWm7Lb2oPOxUzew0fOFG4Lw89v71cdLeag2JlGS5TC07KChTTtgtpsqRJbjXCAW4Lfcq1HvpjAbkNTHAh0kzk~qJxAMvzfD6CozA4etDEbMf-QVQABsZ03khieA5ZoQOFdrgjF7FECS9xSHlD0oC3EO6Tx1jBIhcxeDisPYMzjcc9y9YY0L4Rv-1bnv3mWjq16cvAT89tihfgZpid4dOig85H6CstprZY8wnQSdSvoJMK6RgAsAPxS81jzGFq9MyTzpePBiouGUgLJneQS1xmsRahfkL9DhJkSRfB7braHt-ZAWvQd8gmT5dK0w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/107851886/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/107851886/mini_magick20231126-1-alok6l.png?1701001903"}],"downloadable_attachments_with_full_thumbnails":[{"id":107851886,"asset_id":109852637,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/107851886/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/107851886/j.pan.2013.04.27720231126-1-ztd0ej-libre.pdf?1701001900=\u0026response-content-disposition=attachment%3B+filename%3DCollected_series_of_resected_intraductal.pdf\u0026Expires=1740541145\u0026Signature=a2yirGrC5~9kbWRiXpW98YggS59gWm7Lb2oPOxUzew0fOFG4Lw89v71cdLeag2JlGS5TC07KChTTtgtpsqRJbjXCAW4Lfcq1HvpjAbkNTHAh0kzk~qJxAMvzfD6CozA4etDEbMf-QVQABsZ03khieA5ZoQOFdrgjF7FECS9xSHlD0oC3EO6Tx1jBIhcxeDisPYMzjcc9y9YY0L4Rv-1bnv3mWjq16cvAT89tihfgZpid4dOig85H6CstprZY8wnQSdSvoJMK6RgAsAPxS81jzGFq9MyTzpePBiouGUgLJneQS1xmsRahfkL9DhJkSRfB7braHt-ZAWvQd8gmT5dK0w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/107851886/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/107851886/mini_magick20231126-1-alok6l.png?1701001903"}],"has_pdf":true,"has_fulltext":true,"page_count":1,"ordered_authors":[{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs Tihanyi","profile_url":"https://sote.academia.edu/BTihanyi","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":165,"name":"Pathology","url":"https://www.academia.edu/Documents/in/Pathology","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":true},{"id":92788,"name":"Pancreas","url":"https://www.academia.edu/Documents/in/Pancreas","nofollow":true},{"id":118365,"name":"Mucin","url":"https://www.academia.edu/Documents/in/Mucin","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":364402,"name":"Pancreatology","url":"https://www.academia.edu/Documents/in/Pancreatology"}],"publication_year":2013,"publication_year_with_fallback":2013,"paper_rank":null,"all_time_views":0,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_109852641" data-work_id="109852641" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/109852641/Characteristic_of_the_intraductal_papillary_mucinous_tumours_IPMTs_of_the_pancreas_and_correlation_between_the_presence_of_chronic_pancreatitis_and_the_malignant_potential">Characteristic of the intraductal papillary mucinous tumours (IPMTs) of the pancreas and correlation between the presence of chronic pancreatitis and the malignant potential</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: A histopatologically benign intraductal papillary mucinous neoplasm (IPMN) producing a fistula in adjacent organs are rather scarce. Gas in pancreatic duct is infrequently reported, being associated with peripancreatic... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_109852641" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: A histopatologically benign intraductal papillary mucinous neoplasm (IPMN) producing a fistula in adjacent organs are rather scarce. Gas in pancreatic duct is infrequently reported, being associated with peripancreatic abscess, biliary instrumentation, fistula formation or Oddi sphincter dysfunction. Aims: A clinical case with a 70 years old woman who presented epigastric pain and weight loss is reported. Patients & methods: A 70 years old woman presented epigastric pain and weight loss. CT: dilated main pancreatic duct and pancreatic head destructuration. Fistulous communication in the first duodenal portion. Gas bubbles in the main duct. EUS : dilated main pancreatic duct; intramural nodules and cysts greater than 3 cm in secondary branches. Duodenal endoscopy: wall defect with mucinous discharge. Clinical suspicion: degenerated IPMN. Surgery: pancreatic head mass. Wirsungoscopy found mucinous content, papillary projections and alteration in ductal mucosa. Fistulous communication with duodenum. Whipple duodenopancreatectomy was performed successfully. Anatomopatologic report IPMN with areas of severe pancreatic ductal dysplasia affecting main and secondary ducts. No malignance. Resection margin free of dysplasia. Results: IPMN of the pancreas presents proliferation of mucin-producing papillary epithelial cells, with cystic dilatation of the pancreatic ducts. It's have malignant potential. Fistula is more infrequent by non malignant IPMN. Fistula formation is related with high level of pressure in Wirsung duct and secondary wall digestion by enzyme erich fluid. Conclusion: Combination of benign IPMN, secondary duodenal fistula and gas in wirsung as radiological manifestation is extremely infrequent. W-025. Comparative outcome of resected and non-resected main-duct intraductal papillary mucinous neoplasms of the pancreas</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/109852641" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8fd53898d73b17c0a3cc6419840c566b" rel="nofollow" data-download="{"attachment_id":107851884,"asset_id":109852641,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/107851884/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34686687" href="https://sote.academia.edu/BTihanyi">Balázs Tihanyi</a><script data-card-contents-for-user="34686687" type="text/json">{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs Tihanyi","profile_url":"https://sote.academia.edu/BTihanyi","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_109852641 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="109852641"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 109852641, container: ".js-paper-rank-work_109852641", }); 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Gas in pancreatic duct is infrequently reported, being associated with peripancreatic abscess, biliary instrumentation, fistula formation or Oddi sphincter dysfunction. Aims: A clinical case with a 70 years old woman who presented epigastric pain and weight loss is reported. Patients \u0026 methods: A 70 years old woman presented epigastric pain and weight loss. CT: dilated main pancreatic duct and pancreatic head destructuration. Fistulous communication in the first duodenal portion. Gas bubbles in the main duct. EUS : dilated main pancreatic duct; intramural nodules and cysts greater than 3 cm in secondary branches. Duodenal endoscopy: wall defect with mucinous discharge. Clinical suspicion: degenerated IPMN. Surgery: pancreatic head mass. Wirsungoscopy found mucinous content, papillary projections and alteration in ductal mucosa. Fistulous communication with duodenum. Whipple duodenopancreatectomy was performed successfully. Anatomopatologic report IPMN with areas of severe pancreatic ductal dysplasia affecting main and secondary ducts. No malignance. Resection margin free of dysplasia. Results: IPMN of the pancreas presents proliferation of mucin-producing papillary epithelial cells, with cystic dilatation of the pancreatic ducts. It's have malignant potential. Fistula is more infrequent by non malignant IPMN. Fistula formation is related with high level of pressure in Wirsung duct and secondary wall digestion by enzyme erich fluid. Conclusion: Combination of benign IPMN, secondary duodenal fistula and gas in wirsung as radiological manifestation is extremely infrequent. W-025. Comparative outcome of resected and non-resected main-duct intraductal papillary mucinous neoplasms of the pancreas","publication":"Pancreatology","publication_with_fallback":"Pancreatology","downloadable_attachments":[{"id":107851884,"asset_id":109852641,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/107851884/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/107851884/j.pan.2014.05.47220231126-1-u3eo7r-libre.pdf?1701001901=\u0026response-content-disposition=attachment%3B+filename%3DCharacteristic_of_the_intraductal_papill.pdf\u0026Expires=1740541145\u0026Signature=VzKokCuZFsvO7d4BWKsgZdUzmKzdroaLEFEydPG5eAqwIIsARgBtvv-Z7YA8TYkd29dm037kfLMkSgdP~rj1DCjFvQg23o46wkMcZVTi6~QbY~D028HSqBIRmhBp2~R-gJzVqo-3lVrUQwqfbzwrvJ-~Y9G2Y3ZdaQFUv5KYMS~upAmeVJ9NNGLJ71jXScHGfGBZH7h~7qd7Qtbp0Js86RORxUuAMQePZYGkm-DRRThDktm4v5rGyUBHtCVS2PfJyAZa~kSnGTH4glzw7ZNGdY7Q6P7sW0g5inwewiz6u4daGlYqpcCwgMq4p9-acotOByK8Tx5rr1D5Ia~CfdEiWg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/107851884/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/107851884/mini_magick20231126-1-hm2kqa.png?1701001904"}],"downloadable_attachments_with_full_thumbnails":[{"id":107851884,"asset_id":109852641,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/107851884/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/107851884/j.pan.2014.05.47220231126-1-u3eo7r-libre.pdf?1701001901=\u0026response-content-disposition=attachment%3B+filename%3DCharacteristic_of_the_intraductal_papill.pdf\u0026Expires=1740541145\u0026Signature=VzKokCuZFsvO7d4BWKsgZdUzmKzdroaLEFEydPG5eAqwIIsARgBtvv-Z7YA8TYkd29dm037kfLMkSgdP~rj1DCjFvQg23o46wkMcZVTi6~QbY~D028HSqBIRmhBp2~R-gJzVqo-3lVrUQwqfbzwrvJ-~Y9G2Y3ZdaQFUv5KYMS~upAmeVJ9NNGLJ71jXScHGfGBZH7h~7qd7Qtbp0Js86RORxUuAMQePZYGkm-DRRThDktm4v5rGyUBHtCVS2PfJyAZa~kSnGTH4glzw7ZNGdY7Q6P7sW0g5inwewiz6u4daGlYqpcCwgMq4p9-acotOByK8Tx5rr1D5Ia~CfdEiWg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/107851884/download_file?st=MTc0MDUzNzU0NSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/107851884/mini_magick20231126-1-hm2kqa.png?1701001904"}],"has_pdf":true,"has_fulltext":true,"page_count":2,"ordered_authors":[{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs Tihanyi","profile_url":"https://sote.academia.edu/BTihanyi","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":165,"name":"Pathology","url":"https://www.academia.edu/Documents/in/Pathology","nofollow":true},{"id":21143,"name":"Pancreatitis","url":"https://www.academia.edu/Documents/in/Pancreatitis","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":true},{"id":92788,"name":"Pancreas","url":"https://www.academia.edu/Documents/in/Pancreas","nofollow":true},{"id":118365,"name":"Mucin","url":"https://www.academia.edu/Documents/in/Mucin"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":364402,"name":"Pancreatology","url":"https://www.academia.edu/Documents/in/Pancreatology"},{"id":2588334,"name":"MUC","url":"https://www.academia.edu/Documents/in/MUC"}],"publication_year":2014,"publication_year_with_fallback":2014,"paper_rank":null,"all_time_views":0,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_109852643" data-work_id="109852643" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/109852643/Thrombocytosis_of_Liver_Metastasis_from_Colorectal_Cancer_as_Predictive_Factor">Thrombocytosis of Liver Metastasis from Colorectal Cancer as Predictive Factor</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">There is increasing evidence that thrombocytosis is associated with tumor invasion and metastasis formation. It was shown in several solid tumor types that thrombocytosis prognosticates cancer progression. The aim of this study was to... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_109852643" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">There is increasing evidence that thrombocytosis is associated with tumor invasion and metastasis formation. It was shown in several solid tumor types that thrombocytosis prognosticates cancer progression. The aim of this study was to evaluate preoperative thrombocytosis as a potential prognostic biomarker in isolated metastases, in patients with liver metastasis of colorectal cancer (mCRC). Clinicopathological data of 166 patients with mCRC who had surgical resection between 2001 and 2011 were collected retrospectively. All primary tumors have been already resected. The platelet count was evaluated based on the standard preoperative blood profile. The patients were followed-up on average for 28 months. Overall survival (OS) of patients with thrombocytosis was significantly worse both in univariate (HR=3.00, p=0.03) and in multivariate analysis (HR=4.68, p=0.056) when adjusted for gender, age, tumor size and surgical margin. Thrombocytosis was also a good prognosticator of diseasefree survival (DFS) with HR=2.7, p=0.018 and nearly significant in multivariate setting (HR=2.26, p=0.073). 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It was shown in several solid tumor types that thrombocytosis prognosticates cancer progression. The aim of this study was to evaluate preoperative thrombocytosis as a potential prognostic biomarker in isolated metastases, in patients with liver metastasis of colorectal cancer (mCRC). Clinicopathological data of 166 patients with mCRC who had surgical resection between 2001 and 2011 were collected retrospectively. All primary tumors have been already resected. The platelet count was evaluated based on the standard preoperative blood profile. The patients were followed-up on average for 28 months. Overall survival (OS) of patients with thrombocytosis was significantly worse both in univariate (HR=3.00, p=0.03) and in multivariate analysis (HR=4.68, p=0.056) when adjusted for gender, age, tumor size and surgical margin. Thrombocytosis was also a good prognosticator of diseasefree survival (DFS) with HR=2.7, p=0.018 and nearly significant in multivariate setting (HR=2.26, p=0.073). The platelet count is a valuable prognostic marker for the survival in patients with mCRC.","publication":"Pathology \u0026amp; Oncology Research","publication_with_fallback":"Pathology \u0026amp; Oncology Research","downloadable_attachments":[{"id":108230200,"asset_id":109852643,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/108230200/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/108230200/s12253-015-9925-820231203-1-hiue3x-libre.pdf?1701566761=\u0026response-content-disposition=attachment%3B+filename%3DThrombocytosis_of_Liver_Metastasis_from.pdf\u0026Expires=1740541145\u0026Signature=HOrSZqp9I9U~SUgx9Uv6atJ23jpVG1izLFMgGWxv0jQBNbZzRjf3uyktnIBcPrVP0V~HrAsPOFChj0UlUxn8meIy7foLzqaIqyH4pFUNMEg4WQJ4kXgbi~VGQ4ks2xg8rdmNGBJZMpK7Zg~tTMciA3YD73o4qlxBYZdzw2w924dGIxYB7DAG4vu-0SL9BsgAefQO1kjZ3tuqY7t6w~faAT1qCvX8n9552imIK3PcQFrsMvOSpAv~Qso2eS5EX7-iGZLtZKfaMhpiYykUMypAG6aCjygC48rH1g8YvgErFL~yck5DutaphJkhGNNuHj0k2pl42TJ~Mk2F0JUcf3UHRQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/108230200/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/108230200/mini_magick20231203-1-j5dhxl.png?1701566258"}],"downloadable_attachments_with_full_thumbnails":[{"id":108230200,"asset_id":109852643,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/108230200/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/108230200/s12253-015-9925-820231203-1-hiue3x-libre.pdf?1701566761=\u0026response-content-disposition=attachment%3B+filename%3DThrombocytosis_of_Liver_Metastasis_from.pdf\u0026Expires=1740541146\u0026Signature=F0qee9MOI2Fbc5OVGLMOlfYZRdrP9F5QM5DkxjjE5a5raQf1A3m7k9J1xgTIy2~e3a53DSVu1HUkVgpE91OKmEEOFaRJVCqPGX3yLPu7KdtccNicPulQzP0ZpP0BsHWBfh1mbv1idC7gqitTKYfCkaRqkE80wvemk68iREXuRuDeczPYhR~2UcpbVlaXSqBpWZtt6FCs0iOinhgm-ytjPqzecJe-iFNaZAMUCA3n4Iqgx-fBLj3P8XJsNsKmJhyDXlKnuzIRpIsaTDHp84gZMhgDVUqheIB7KFXNMtsdkb384X8iazjYw1gwr6a8y4PwfCghsnGAsBJcC47axbHldA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/108230200/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/108230200/mini_magick20231203-1-j5dhxl.png?1701566258"}],"has_pdf":true,"has_fulltext":true,"page_count":7,"ordered_authors":[{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs 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class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_109852644" data-work_id="109852644" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/109852644/Coexistence_of_a_pancreatic_serous_cystadenoma_and_a_VIP_producing_neuroendocrine_tumor">Coexistence of a pancreatic serous cystadenoma and a VIP-producing neuroendocrine tumor</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To assess the postoperative morbidity and survival of patients with resectable PDA of the body and tail (PDA-BT); to evaluate prognostic factors for survival. Patients & methods: Between 1997 and 2011, 33 patients with histologically... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_109852644" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To assess the postoperative morbidity and survival of patients with resectable PDA of the body and tail (PDA-BT); to evaluate prognostic factors for survival. Patients & methods: Between 1997 and 2011, 33 patients with histologically proven PDA-BT who underwent distal pancreatectomy (DP) (multivisceral resections in 39%) were retrospectively analyzed. Radical antegrade modular pancreatosplenectomy (RAMPS) was used in 66.6% (starting 2004). All patients received adjuvant chemotherapy. Clinicopathological factors associated with survival were statistically evaluated. Results: Postoperative morbidity was 45.4%. One patient died (3%). Median survival was 22.8 months. The 1-, 3-, and 5-years overall survival rates were 78%, 39.3% and 12.1% respectively. There was no significant difference in survival for patients operated by standard DP or RAMPS procedure. Significant prognostic factors of survival were: positive lymph nodes, tumor differentiation (>G3), R2 resection, adjuvant therapy, splenic artery invasion, and severe complications (grade III-IV, Clavien classification). When complications delay adjuvant chemotherapy with more than 30days (comparing with patients with no severe complications), survival is significantly lower (median survival 17 versus 24.1months, p¼0.07). Difference is higher in R1 resections (median survival 9 versus 23.4months, p¼0.0006). Conclusion: Resectable PDA-BT has a survival comparable with pancreatic head cancer, but a higher morbidity. Along with other wellknown prognostic factors, severe postoperative complications are an independent predictor of survival, by delaying adjuvant chemotherapy, especially in R1 resections. More efforts should be done for an earlier diagnosis, to avoid multivisceral resections which favor severe morbidity.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/109852644" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c777669e51bc39e22e79fcdff3f1e5d9" rel="nofollow" data-download="{"attachment_id":107851885,"asset_id":109852644,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/107851885/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34686687" href="https://sote.academia.edu/BTihanyi">Balázs Tihanyi</a><script data-card-contents-for-user="34686687" type="text/json">{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs Tihanyi","profile_url":"https://sote.academia.edu/BTihanyi","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_109852644 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="109852644"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 109852644, container: ".js-paper-rank-work_109852644", }); 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$(".js-view-count[data-work-id=109852644]").text(description); $(".js-view-count-work_109852644").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_109852644").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="109852644"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="364402" rel="nofollow" href="https://www.academia.edu/Documents/in/Pancreatology">Pancreatology</a>, <script data-card-contents-for-ri="364402" type="text/json">{"id":364402,"name":"Pancreatology","url":"https://www.academia.edu/Documents/in/Pancreatology","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2486447" rel="nofollow" href="https://www.academia.edu/Documents/in/SEROUS_CYSTADENOMA">SEROUS CYSTADENOMA</a><script data-card-contents-for-ri="2486447" type="text/json">{"id":2486447,"name":"SEROUS CYSTADENOMA","url":"https://www.academia.edu/Documents/in/SEROUS_CYSTADENOMA","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=109852644]'), work: {"id":109852644,"title":"Coexistence of a pancreatic serous cystadenoma and a VIP-producing neuroendocrine tumor","created_at":"2023-11-26T04:30:01.254-08:00","owner_id":34686687,"url":"https://www.academia.edu/109852644/Coexistence_of_a_pancreatic_serous_cystadenoma_and_a_VIP_producing_neuroendocrine_tumor","slug":"Coexistence_of_a_pancreatic_serous_cystadenoma_and_a_VIP_producing_neuroendocrine_tumor","dom_id":"work_109852644","summary":"To assess the postoperative morbidity and survival of patients with resectable PDA of the body and tail (PDA-BT); to evaluate prognostic factors for survival. Patients \u0026 methods: Between 1997 and 2011, 33 patients with histologically proven PDA-BT who underwent distal pancreatectomy (DP) (multivisceral resections in 39%) were retrospectively analyzed. Radical antegrade modular pancreatosplenectomy (RAMPS) was used in 66.6% (starting 2004). All patients received adjuvant chemotherapy. Clinicopathological factors associated with survival were statistically evaluated. Results: Postoperative morbidity was 45.4%. One patient died (3%). Median survival was 22.8 months. The 1-, 3-, and 5-years overall survival rates were 78%, 39.3% and 12.1% respectively. There was no significant difference in survival for patients operated by standard DP or RAMPS procedure. Significant prognostic factors of survival were: positive lymph nodes, tumor differentiation (\u003eG3), R2 resection, adjuvant therapy, splenic artery invasion, and severe complications (grade III-IV, Clavien classification). When complications delay adjuvant chemotherapy with more than 30days (comparing with patients with no severe complications), survival is significantly lower (median survival 17 versus 24.1months, p¼0.07). Difference is higher in R1 resections (median survival 9 versus 23.4months, p¼0.0006). Conclusion: Resectable PDA-BT has a survival comparable with pancreatic head cancer, but a higher morbidity. Along with other wellknown prognostic factors, severe postoperative complications are an independent predictor of survival, by delaying adjuvant chemotherapy, especially in R1 resections. More efforts should be done for an earlier diagnosis, to avoid multivisceral resections which favor severe morbidity.","publication":"Pancreatology","publication_with_fallback":"Pancreatology","downloadable_attachments":[{"id":107851885,"asset_id":109852644,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/107851885/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/107851885/j.pan.2015.05.39320231126-1-8dgzov-libre.pdf?1701001900=\u0026response-content-disposition=attachment%3B+filename%3DCoexistence_of_a_pancreatic_serous_cysta.pdf\u0026Expires=1740541146\u0026Signature=gvGtKDVgEqTKT7mtUBd-MzENWycP3iGIVoQHN-BSeStbIWlKnYNisHyJH-u-iArsUu7prNzjRydNMnA2iWrZK3Nk9W1dcNz2iE-fS7M1aipzczBXiylyG-gnhxfMVaB6ZcJrcFfTmsBwlEQmSQXadEQ5RCH8wzUo6NfOTJ1lokwbokdwGRQqTbeOK7-K3v0NIUCv6YbCN9-BRcfTxzsO587Hv2TSSu4qWxFdMvaUQo7V6D-g1YPXFV8CeCXVzeS-7DV6Csf~mYXO-9uUidFtr~5dIgYw3QiR7zEkZIGAGdrODjrnjXWPnCrLZmEiWdstVDmDmZZcf6qz18WMn9hU5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/107851885/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/107851885/mini_magick20231126-1-fsy1yd.png?1701001916"}],"downloadable_attachments_with_full_thumbnails":[{"id":107851885,"asset_id":109852644,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/107851885/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/107851885/j.pan.2015.05.39320231126-1-8dgzov-libre.pdf?1701001900=\u0026response-content-disposition=attachment%3B+filename%3DCoexistence_of_a_pancreatic_serous_cysta.pdf\u0026Expires=1740541146\u0026Signature=gvGtKDVgEqTKT7mtUBd-MzENWycP3iGIVoQHN-BSeStbIWlKnYNisHyJH-u-iArsUu7prNzjRydNMnA2iWrZK3Nk9W1dcNz2iE-fS7M1aipzczBXiylyG-gnhxfMVaB6ZcJrcFfTmsBwlEQmSQXadEQ5RCH8wzUo6NfOTJ1lokwbokdwGRQqTbeOK7-K3v0NIUCv6YbCN9-BRcfTxzsO587Hv2TSSu4qWxFdMvaUQo7V6D-g1YPXFV8CeCXVzeS-7DV6Csf~mYXO-9uUidFtr~5dIgYw3QiR7zEkZIGAGdrODjrnjXWPnCrLZmEiWdstVDmDmZZcf6qz18WMn9hU5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/107851885/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/107851885/mini_magick20231126-1-fsy1yd.png?1701001916"}],"has_pdf":true,"has_fulltext":true,"page_count":2,"ordered_authors":[{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs Tihanyi","profile_url":"https://sote.academia.edu/BTihanyi","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences","nofollow":true},{"id":364402,"name":"Pancreatology","url":"https://www.academia.edu/Documents/in/Pancreatology","nofollow":true},{"id":2486447,"name":"SEROUS CYSTADENOMA","url":"https://www.academia.edu/Documents/in/SEROUS_CYSTADENOMA","nofollow":true}],"publication_year":2015,"publication_year_with_fallback":2015,"paper_rank":null,"all_time_views":0,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_109852645" data-work_id="109852645" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/109852645/Paraneoplastic_thrombocytosis_in_gastrointestinal_cancer">Paraneoplastic thrombocytosis in gastrointestinal cancer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Paraneoplastic thrombocytosis in gastrointestinal cancer It has been demonstrated recently in several solid tumors that thrombocytosis at diagnosis may correlate with tumor invasion, metastatic progression and worse outcome. Several... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_109852645" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Paraneoplastic thrombocytosis in gastrointestinal cancer It has been demonstrated recently in several solid tumors that thrombocytosis at diagnosis may correlate with tumor invasion, metastatic progression and worse outcome. Several details of the pathomechanism of the relationship of thrombocytosis and cancer have been elucidated; however, the complete process is not clearly understood. Several hypotheses have been proposed. Recently, it was suggested that in ovarian cancer elevated IL-6 production by the tumor may induce increased megakaryopoiesis via hepatic thrombopoietin production leading to thrombocytosis. The importance of the prognostic power of elevated platelet count is still debated in gastrointestinal cancer. The aims of this review were to evaluate the prognostic significance of thrombocytosis in gastrointestinal tumors, to see whether clinical practice confirmed the hypotheses and to reveal the causes of the inconsistent findings.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/109852645" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9a6f673d90f496888ebdf5461ddc6dfa" rel="nofollow" data-download="{"attachment_id":107851887,"asset_id":109852645,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/107851887/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34686687" href="https://sote.academia.edu/BTihanyi">Balázs Tihanyi</a><script data-card-contents-for-user="34686687" type="text/json">{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs Tihanyi","profile_url":"https://sote.academia.edu/BTihanyi","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_109852645 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="109852645"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 109852645, container: ".js-paper-rank-work_109852645", }); 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$(".js-view-count[data-work-id=109852645]").text(description); $(".js-view-count-work_109852645").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_109852645").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="109852645"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6021" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="23319" rel="nofollow" href="https://www.academia.edu/Documents/in/Ovarian_Cancer">Ovarian Cancer</a>, <script data-card-contents-for-ri="23319" type="text/json">{"id":23319,"name":"Ovarian Cancer","url":"https://www.academia.edu/Documents/in/Ovarian_Cancer","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52136" rel="nofollow" href="https://www.academia.edu/Documents/in/Platelet">Platelet</a><script data-card-contents-for-ri="52136" type="text/json">{"id":52136,"name":"Platelet","url":"https://www.academia.edu/Documents/in/Platelet","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=109852645]'), work: {"id":109852645,"title":"Paraneoplastic thrombocytosis in gastrointestinal cancer","created_at":"2023-11-26T04:30:01.409-08:00","owner_id":34686687,"url":"https://www.academia.edu/109852645/Paraneoplastic_thrombocytosis_in_gastrointestinal_cancer","slug":"Paraneoplastic_thrombocytosis_in_gastrointestinal_cancer","dom_id":"work_109852645","summary":"Paraneoplastic thrombocytosis in gastrointestinal cancer It has been demonstrated recently in several solid tumors that thrombocytosis at diagnosis may correlate with tumor invasion, metastatic progression and worse outcome. Several details of the pathomechanism of the relationship of thrombocytosis and cancer have been elucidated; however, the complete process is not clearly understood. Several hypotheses have been proposed. Recently, it was suggested that in ovarian cancer elevated IL-6 production by the tumor may induce increased megakaryopoiesis via hepatic thrombopoietin production leading to thrombocytosis. The importance of the prognostic power of elevated platelet count is still debated in gastrointestinal cancer. The aims of this review were to evaluate the prognostic significance of thrombocytosis in gastrointestinal tumors, to see whether clinical practice confirmed the hypotheses and to reveal the causes of the inconsistent findings.","publication":"Platelets","publication_with_fallback":"Platelets","downloadable_attachments":[{"id":107851887,"asset_id":109852645,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/107851887/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/107851887/43258609-libre.pdf?1701001900=\u0026response-content-disposition=attachment%3B+filename%3DParaneoplastic_thrombocytosis_in_gastroi.pdf\u0026Expires=1740541146\u0026Signature=NsTKMe~KSD4o09OHu9yW0Ld6Wbs7tQK3sQQigZoQAiUTlXVhqL0lBil2FE2jTpRiDcQO83hPSj4DL3ng1CrU6ijTD1JvLoFSntwxE45CAFTEIp3RR8ZOTBjUZvWinB3uoccEOELuEpB-E3oP3UsTZeI~cqxoUAl5Fi4tdnF8WSVkk8zrMd12e8rmQAa4QEtb8JKeFuE2CDL7x3jek6zuib4YMVndVfxvedSjMlgIsCbfRi5C51G~BPp~c545050Hm4T4rZwVX4NRH4WT5udtp3V6FBUptM9DJXTpfQ1aHI~XgxtJ0U3kndDJ6G2M07Wn9PrxHnTAit~nCCV1QMIpZA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/107851887/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/107851887/mini_magick20231126-1-6psqxy.png?1701001902"}],"downloadable_attachments_with_full_thumbnails":[{"id":107851887,"asset_id":109852645,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/107851887/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/107851887/43258609-libre.pdf?1701001900=\u0026response-content-disposition=attachment%3B+filename%3DParaneoplastic_thrombocytosis_in_gastroi.pdf\u0026Expires=1740541146\u0026Signature=NsTKMe~KSD4o09OHu9yW0Ld6Wbs7tQK3sQQigZoQAiUTlXVhqL0lBil2FE2jTpRiDcQO83hPSj4DL3ng1CrU6ijTD1JvLoFSntwxE45CAFTEIp3RR8ZOTBjUZvWinB3uoccEOELuEpB-E3oP3UsTZeI~cqxoUAl5Fi4tdnF8WSVkk8zrMd12e8rmQAa4QEtb8JKeFuE2CDL7x3jek6zuib4YMVndVfxvedSjMlgIsCbfRi5C51G~BPp~c545050Hm4T4rZwVX4NRH4WT5udtp3V6FBUptM9DJXTpfQ1aHI~XgxtJ0U3kndDJ6G2M07Wn9PrxHnTAit~nCCV1QMIpZA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/107851887/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/107851887/mini_magick20231126-1-6psqxy.png?1701001902"}],"has_pdf":true,"has_fulltext":true,"page_count":2,"ordered_authors":[{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs 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href="https://www.academia.edu/109852646/Diagnosis_and_treatment_in_chronic_pancreatitis_an_international_survey_and_case_vignette_study">Diagnosis and treatment in chronic pancreatitis: an international survey and case vignette study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: The aim of the study was to evaluate the current opinion and clinical decision-making process of international pancreatologists, and to systematically identify key study questions regarding the diagnosis and treatment of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_109852646" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: The aim of the study was to evaluate the current opinion and clinical decision-making process of international pancreatologists, and to systematically identify key study questions regarding the diagnosis and treatment of chronic pancreatitis (CP) for future research. Methods: An online survey, including questions regarding the diagnosis and treatment of CP and several controversial clinical case vignettes, was send by e-mail to members of various international pancreatic associations: IHPBA, APA, EPC, ESGE and DPSG. Results: A total of 288 pancreatologists, 56% surgeons and 44% gastroenterologists, from at least 47 countries, participated in the survey. About half (48%) of the specialists used a classification tool for the diagnosis of CP, including the Mayo Clinic (28%), Mannheim (25%), or Büchler (25%) tools. Overall, CT was the preferred imaging modality for evaluation of an enlarged pancreatic head (59%), pseudocyst (55%), calcifications (75%), and peripancreatic fat infiltration (68%). MRI was preferred for assessment of main pancreatic duct (MPD) abnormalities (60%). Total pancreatectomy with auto-islet transplantation was the preferred treatment in patients with parenchymal calcifications without MPD abnormalities and in patients with refractory pain despite maximal medical, endoscopic, and surgical treatment. In patients with an enlarged pancreatic head, 58% preferred initial surgery (PPPD) versus 42% initial endoscopy. In patients with a dilated MPD and intraductal stones 56% preferred initial endoscopic ± ESWL treatment and 29% preferred initial surgical treatment. Conclusion: Worldwide, clinical decision-making in CP is largely based on local expertise, beliefs and disbeliefs. Further development of evidence-based guidelines based on well designed (randomized) studies is strongly encouraged.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/109852646" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f0f2f331df90cdccf7d09c986aa2761d" rel="nofollow" data-download="{"attachment_id":107851904,"asset_id":109852646,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/107851904/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34686687" href="https://sote.academia.edu/BTihanyi">Balázs Tihanyi</a><script data-card-contents-for-user="34686687" type="text/json">{"id":34686687,"first_name":"Balázs","last_name":"Tihanyi","domain_name":"sote","page_name":"BTihanyi","display_name":"Balázs Tihanyi","profile_url":"https://sote.academia.edu/BTihanyi","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_109852646 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="109852646"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 109852646, container: ".js-paper-rank-work_109852646", }); 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$(".js-view-count[data-work-id=109852646]").text(description); $(".js-view-count-work_109852646").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_109852646").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="109852646"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3274" rel="nofollow" href="https://www.academia.edu/Documents/in/Gastroenterology">Gastroenterology</a>, <script data-card-contents-for-ri="3274" type="text/json">{"id":3274,"name":"Gastroenterology","url":"https://www.academia.edu/Documents/in/Gastroenterology","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="21143" rel="nofollow" href="https://www.academia.edu/Documents/in/Pancreatitis">Pancreatitis</a><script data-card-contents-for-ri="21143" type="text/json">{"id":21143,"name":"Pancreatitis","url":"https://www.academia.edu/Documents/in/Pancreatitis","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=109852646]'), work: {"id":109852646,"title":"Diagnosis and treatment in chronic pancreatitis: an international survey and case vignette study","created_at":"2023-11-26T04:30:01.665-08:00","owner_id":34686687,"url":"https://www.academia.edu/109852646/Diagnosis_and_treatment_in_chronic_pancreatitis_an_international_survey_and_case_vignette_study","slug":"Diagnosis_and_treatment_in_chronic_pancreatitis_an_international_survey_and_case_vignette_study","dom_id":"work_109852646","summary":"Background: The aim of the study was to evaluate the current opinion and clinical decision-making process of international pancreatologists, and to systematically identify key study questions regarding the diagnosis and treatment of chronic pancreatitis (CP) for future research. Methods: An online survey, including questions regarding the diagnosis and treatment of CP and several controversial clinical case vignettes, was send by e-mail to members of various international pancreatic associations: IHPBA, APA, EPC, ESGE and DPSG. Results: A total of 288 pancreatologists, 56% surgeons and 44% gastroenterologists, from at least 47 countries, participated in the survey. About half (48%) of the specialists used a classification tool for the diagnosis of CP, including the Mayo Clinic (28%), Mannheim (25%), or Büchler (25%) tools. Overall, CT was the preferred imaging modality for evaluation of an enlarged pancreatic head (59%), pseudocyst (55%), calcifications (75%), and peripancreatic fat infiltration (68%). MRI was preferred for assessment of main pancreatic duct (MPD) abnormalities (60%). Total pancreatectomy with auto-islet transplantation was the preferred treatment in patients with parenchymal calcifications without MPD abnormalities and in patients with refractory pain despite maximal medical, endoscopic, and surgical treatment. In patients with an enlarged pancreatic head, 58% preferred initial surgery (PPPD) versus 42% initial endoscopy. In patients with a dilated MPD and intraductal stones 56% preferred initial endoscopic ± ESWL treatment and 29% preferred initial surgical treatment. Conclusion: Worldwide, clinical decision-making in CP is largely based on local expertise, beliefs and disbeliefs. Further development of evidence-based guidelines based on well designed (randomized) studies is strongly 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href="https://www.academia.edu/16025076/Functional_Evaluation_of_Multidrug_Resistance_Transporter_Activity_in_Surgical_Samples_of_Solid_Tumors">Functional Evaluation of Multidrug Resistance Transporter Activity in Surgical Samples of Solid Tumors</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Determination of multidrug resistance (MDR) activity of tumor cells could provide important information for the personalized therapy of cancer patients. The functional calcein assay (MultiDrug Quant Assay™, Solvo Biotechnology, Budaörs,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16025076" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Determination of multidrug resistance (MDR) activity of tumor cells could provide important information for the personalized therapy of cancer patients. The functional calcein assay (MultiDrug Quant Assay™, Solvo Biotechnology, Budaörs, Hungary) has been proven to be clinically valuable in hematological malignancies by determining the transporter activity of MDR protein 1 (MDR1, ATP-binding cassette protein [ABC] B1, P-glycoprotein-170) and MDR-related protein 1 (MRP1, ABCC1). In this study, we evaluated if the same functional test was adaptable for the analysis of MDR activity in solid tumors. For this purpose, tissue specimens of human colorectal cancer samples were subjected to limited enzymatic digestion by collagenase to provide a single-cell suspension; dead cells were excluded by 7-aminoactinomycin D staining, and epithelial cancer cells were detected by Cy5-conjugated anti-BerEP4 monoclonal antibody. The transporter functions of MDR1 and MRP1 in viable epithelial cells were assessed by flow cytometry detecting the intracellular accumulation of calcein dye after exposing cells to various MDR inhibitors. Collagenase disintegration preserved the MDR activity and the antigenicity of tumor cells. Thus using the extended calcein assay provided sufficient viable and functionally active tumor cells from surgical biopsies to determine the functional MDR activity. In conclusion, the newly described modified calcein assay may be applicable for evaluating the MDR phenotype in solid tissue specimens from colorectal forceps biopsy to surgical samples.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16025076" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f3938f312e4f0f5503064536aec70efb" rel="nofollow" data-download="{"attachment_id":42781912,"asset_id":16025076,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42781912/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35166030" href="https://independent.academia.edu/Tam%C3%A1sMicsik">Tamás Micsik</a><script data-card-contents-for-user="35166030" type="text/json">{"id":35166030,"first_name":"Tamás","last_name":"Micsik","domain_name":"independent","page_name":"TamásMicsik","display_name":"Tamás Micsik","profile_url":"https://independent.academia.edu/Tam%C3%A1sMicsik","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16025076">+3</span><div class="hidden js-additional-users-16025076"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/OrsolyaSzokol%C3%B3czi">Orsolya Szokolóczi</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://sote.academia.edu/P%C3%A9terKupcsulik">Péter Kupcsulik</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/BSarkadi">Balazs Sarkadi</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16025076'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16025076').html(); 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The functional calcein assay (MultiDrug Quant Assay™, Solvo Biotechnology, Budaörs, Hungary) has been proven to be clinically valuable in hematological malignancies by determining the transporter activity of MDR protein 1 (MDR1, ATP-binding cassette protein [ABC] B1, P-glycoprotein-170) and MDR-related protein 1 (MRP1, ABCC1). In this study, we evaluated if the same functional test was adaptable for the analysis of MDR activity in solid tumors. For this purpose, tissue specimens of human colorectal cancer samples were subjected to limited enzymatic digestion by collagenase to provide a single-cell suspension; dead cells were excluded by 7-aminoactinomycin D staining, and epithelial cancer cells were detected by Cy5-conjugated anti-BerEP4 monoclonal antibody. The transporter functions of MDR1 and MRP1 in viable epithelial cells were assessed by flow cytometry detecting the intracellular accumulation of calcein dye after exposing cells to various MDR inhibitors. Collagenase disintegration preserved the MDR activity and the antigenicity of tumor cells. Thus using the extended calcein assay provided sufficient viable and functionally active tumor cells from surgical biopsies to determine the functional MDR activity. In conclusion, the newly described modified calcein assay may be applicable for evaluating the MDR phenotype in solid tissue specimens from colorectal forceps biopsy to surgical samples.","publication":"ASSAY and Drug Development Technologies","publication_with_fallback":"ASSAY and Drug Development 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Micsik","profile_url":"https://independent.academia.edu/Tam%C3%A1sMicsik","photo":"/images/s65_no_pic.png"},{"id":35286146,"first_name":"Orsolya","last_name":"Szokolóczi","domain_name":"independent","page_name":"OrsolyaSzokolóczi","display_name":"Orsolya Szokolóczi","profile_url":"https://independent.academia.edu/OrsolyaSzokol%C3%B3czi","photo":"https://0.academia-photos.com/35286146/79567926/68134974/s65_orsolya.szokol_czi.jpeg"},{"id":35249783,"first_name":"Péter","last_name":"Kupcsulik","domain_name":"sote","page_name":"PéterKupcsulik","display_name":"Péter Kupcsulik","profile_url":"https://sote.academia.edu/P%C3%A9terKupcsulik","photo":"/images/s65_no_pic.png"},{"id":59414158,"first_name":"Balazs","last_name":"Sarkadi","domain_name":"independent","page_name":"BSarkadi","display_name":"Balazs Sarkadi","profile_url":"https://independent.academia.edu/BSarkadi","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":31837,"name":"Cell 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Fluids","url":"https://www.academia.edu/Documents/in/Body_Fluids"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":2036528,"name":"Keratins","url":"https://www.academia.edu/Documents/in/Keratins"}],"publication_year":2007,"publication_year_with_fallback":2007,"paper_rank":null,"all_time_views":13,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16134317 coauthored" data-work_id="16134317" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16134317/Short_term_alanyl_glutamine_dipeptide_pretreatment_in_liver_ischemia_reperfusion_model_Effects_on_microcirculation_and_antioxidant_status_in_rats">Short-term alanyl-glutamine dipeptide pretreatment in liver ischemia–reperfusion model: Effects on microcirculation and antioxidant status in rats</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background & aims: Ischemia-reperfusion (I-R) injury is responsible for the morbidity associated with liver surgery. Production of toxic free radicals influences the microcirculation. The aim of our study was to examine the effect of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16134317" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background & aims: Ischemia-reperfusion (I-R) injury is responsible for the morbidity associated with liver surgery. Production of toxic free radicals influences the microcirculation. The aim of our study was to examine the effect of glutamine (Gln) supplementation-adminstered in alanyl-glutamine dipeptide form-on liver function, immuno/histopathology and the oxidative state of the liver after injury. Methods: Two-hundred and fifty grams male Wistar rats underwent normothermic, 60 min, segmental liver ischemia followed by 6 h of reperfusion. The animals (n ¼ 45) were divided into three groups: sham operated, I-R and parenteral Gln pretreatment. Hepatic microcirculation was monitored by laser Doppler flowmetry. At the 6 h of reperfusion, histological alterations, TUNEL reaction, active caspase-3 reaction, serum and liver tissue antioxidant levels, serum ALAT, ASAT and TNF-a levels were measured. Results: Upon reperfusion, the Gln group had significantly (po0.05) higher flow rates than the I-R group and, at the end of the 6 h of reperfusion, significantly (po0.05) lower serum ALAT and ASAT levels. The liver chemiluminescent intensity was lower, free SH-groups were elevated, while the reducing power was decreased in the Gln-pretreated group. 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Production of toxic free radicals influences the microcirculation. The aim of our study was to examine the effect of glutamine (Gln) supplementation-adminstered in alanyl-glutamine dipeptide form-on liver function, immuno/histopathology and the oxidative state of the liver after injury. Methods: Two-hundred and fifty grams male Wistar rats underwent normothermic, 60 min, segmental liver ischemia followed by 6 h of reperfusion. The animals (n ¼ 45) were divided into three groups: sham operated, I-R and parenteral Gln pretreatment. Hepatic microcirculation was monitored by laser Doppler flowmetry. At the 6 h of reperfusion, histological alterations, TUNEL reaction, active caspase-3 reaction, serum and liver tissue antioxidant levels, serum ALAT, ASAT and TNF-a levels were measured. Results: Upon reperfusion, the Gln group had significantly (po0.05) higher flow rates than the I-R group and, at the end of the 6 h of reperfusion, significantly (po0.05) lower serum ALAT and ASAT levels. The liver chemiluminescent intensity was lower, free SH-groups were elevated, while the reducing power was decreased in the Gln-pretreated group. Positive","publication":"Clinical Nutrition","publication_with_fallback":"Clinical Nutrition","downloadable_attachments":[{"id":42685486,"asset_id":16134317,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42685486/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42685486/j.clnu.2007.06.011-libre.pdf20160214-14180-o515lf?1455503194=\u0026response-content-disposition=attachment%3B+filename%3DShort_term_alanyl_glutamine_dipeptide_pr.pdf\u0026Expires=1740506238\u0026Signature=ROl2xDUMBstkTzt3tel46qioXvhie9ykC91g1oeHzAOyRpD4xtbe9rcEfqgE1j1xqgVCH3UpAlx-98QosiqQmGJeh-XCxdFkS3pWmBIMnNssnv0fDUXYhWzYXdf2S24ZLpbAgSw94CLwz4Nf7aiszlq1MChZsvpdxSlpLVJbvJFBphuKTV8WbtrAZLjJ4MlnJojdt0plC33~WozSDmQUJkl8yDYtf8Jx6dGKXYdDwt4pJQggLeqp9ZoZfI1eEbXjvCaeNw5PkZMFTTBXE9g1X2RsPH9rOZjcpRD-MNE80Z-y38kWzpku7C9reBbFw3GV~aiQJMa2GRu0GdG6PS8nlQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42685486/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42685486/mini_magick20190217-27717-1u5o8oc.png?1550417303"}],"downloadable_attachments_with_full_thumbnails":[{"id":42685486,"asset_id":16134317,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42685486/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42685486/j.clnu.2007.06.011-libre.pdf20160214-14180-o515lf?1455503194=\u0026response-content-disposition=attachment%3B+filename%3DShort_term_alanyl_glutamine_dipeptide_pr.pdf\u0026Expires=1740506239\u0026Signature=SJDu705RgOkrGX2Imjk12wctcFn-27zbTvzjfX0fabZ~vOrSMaBlWOQsvljJTf2C1Re1kiL7Jrh08cW8Z3s24LuK3PXUs-~DZfdzykeNF~TLux0NtW240vgQVupkXhjVdiR0KIh9z6r7ijgGiL8aZ3V8YyHcvQuSeSi5FAAnL-ag3EVmniBeDoCNBuhoN09qojl7V-y6GuAMS2VTj3NwimCIvqxexmlktYBO1pSuvBz-HYGY5-dIcRlAgM8mYJE1WIBZGmhvoiSS1ESotFo6SNCJiMw1rww-8DoAn4uC2SZRyN95yOyyRpNcUFrmhhJqnMcOJ18fBa7UIE2yT7pGsw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42685486/download_file?st=MTc0MDUzNzU0Niw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42685486/mini_magick20190217-27717-1u5o8oc.png?1550417303"}],"has_pdf":true,"has_fulltext":true,"page_count":9,"ordered_authors":[{"id":35367123,"first_name":"Attila","last_name":"Szijártó","domain_name":"sote","page_name":"AttilaSzijártó","display_name":"Attila Szijártó","profile_url":"https://sote.academia.edu/AttilaSzij%C3%A1rt%C3%B3","photo":"/images/s65_no_pic.png"},{"id":35249783,"first_name":"Péter","last_name":"Kupcsulik","domain_name":"sote","page_name":"PéterKupcsulik","display_name":"Péter Kupcsulik","profile_url":"https://sote.academia.edu/P%C3%A9terKupcsulik","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics","nofollow":true},{"id":8017,"name":"Microcirculation","url":"https://www.academia.edu/Documents/in/Microcirculation","nofollow":true},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry","nofollow":true},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis","nofollow":true},{"id":51711,"name":"Antioxidants","url":"https://www.academia.edu/Documents/in/Antioxidants"},{"id":59614,"name":"Clinical Nutrition","url":"https://www.academia.edu/Documents/in/Clinical_Nutrition"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver"},{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species"},{"id":247477,"name":"Caspase","url":"https://www.academia.edu/Documents/in/Caspase"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats"},{"id":794984,"name":"Reperfusion injury","url":"https://www.academia.edu/Documents/in/Reperfusion_injury"},{"id":1030673,"name":"Ischemia–reperfusion","url":"https://www.academia.edu/Documents/in/Ischemia_reperfusion"},{"id":1281378,"name":"Aspartate Aminotransferases","url":"https://www.academia.edu/Documents/in/Aspartate_Aminotransferases"},{"id":2112739,"name":"Alanine Transaminase","url":"https://www.academia.edu/Documents/in/Alanine_Transaminase"}],"publication_year":2007,"publication_year_with_fallback":2007,"paper_rank":null,"all_time_views":18,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16134318 coauthored" data-work_id="16134318" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16134318/P075_PARENTERAL_GLUTAMINE_PRETREATMENT_REDUCES_LOCAL_TISSUE_DAMAGE_AFTER_ISCHEMIA_REPERFUSION_INJURY_OF_THE_LIVER_IN_RATS">P075 PARENTERAL GLUTAMINE PRETREATMENT REDUCES LOCAL TISSUE DAMAGE AFTER ISCHEMIA-REPERFUSION INJURY OF THE LIVER IN RATS</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Rationale: Surgical methods aimed to reduce bleeding during major hepatic resections, result in warm ischemiareperfusion (I-R) injury of the liver, which has considerable impact on the postoperative outcome. Great research work has been... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16134318" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Rationale: Surgical methods aimed to reduce bleeding during major hepatic resections, result in warm ischemiareperfusion (I-R) injury of the liver, which has considerable impact on the postoperative outcome. Great research work has been done to invent possible protective techniques. We aimed to investigate whether L-alanyl-L-glutamine dipeptide pretreatment administered at different time points preoperatively could reduce hepatic I-R injury, according to histological samples and serum necroenzyme levels. Methods: Male Wistar rats (n = 60), received an immediately preoperative ("short term" group), or a 24hrs earlier administered ("long term" group) Dipeptiven ® infusion and underwent normothermic, 60min, segmental liver ischemia followed by 6hrs or 24hrs of reperfusion, respectively. Histological and blood samples were taken at the end of reperfusion. Liver tissue damage was assessed by morphometric analysis, different immunohistochemical reactions and serum necroenzyme levels. The samples of pretreated animals were compared to the matching sham operated, and I-R groups. Results: Inflammatory reaction in the hematoxilyneosin stained liver samples was significantly lower in the pretreated groups and tissue integrity was more preserved, while high rate of necrosis could be seen in the control samples. In the "short term" group, more apoptotic cells could be observed with anti-caspase-3 reaction, while the "long term" pretreatment was found to reduce lipoid degeneration and tissue poly-(ADPribose) polymerase activation. Together with lower tissue damage, serum ALT and AST levels were significantly lower (p = 0.045 for "short term" and p = 0.038 for "long term" pretreatment). Conclusion: Our results suggest, that preoperative L-alanyl-L-glutamine dipeptide pretreatment, could be an effective method to prevent hepatocellular necrosis after liver I-R injury.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16134318" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="089e90380410a1a85ef0bbbaf7cfa34f" rel="nofollow" data-download="{"attachment_id":42685471,"asset_id":16134318,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42685471/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35367123" href="https://sote.academia.edu/AttilaSzij%C3%A1rt%C3%B3">Attila Szijártó</a><script data-card-contents-for-user="35367123" type="text/json">{"id":35367123,"first_name":"Attila","last_name":"Szijártó","domain_name":"sote","page_name":"AttilaSzijártó","display_name":"Attila Szijártó","profile_url":"https://sote.academia.edu/AttilaSzij%C3%A1rt%C3%B3","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16134318">+1</span><div class="hidden js-additional-users-16134318"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://sote.academia.edu/P%C3%A9terKupcsulik">Péter Kupcsulik</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16134318'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16134318').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16134318 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16134318"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16134318; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16134318]").text(description); $(".js-view-count-work_16134318").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16134318").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16134318"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="591" rel="nofollow" href="https://www.academia.edu/Documents/in/Nutrition_and_Dietetics">Nutrition and Dietetics</a>, <script data-card-contents-for-ri="591" type="text/json">{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="50948" rel="nofollow" href="https://www.academia.edu/Documents/in/Ischemia_Reperfusion_Injury">Ischemia Reperfusion Injury</a><script data-card-contents-for-ri="50948" type="text/json">{"id":50948,"name":"Ischemia Reperfusion Injury","url":"https://www.academia.edu/Documents/in/Ischemia_Reperfusion_Injury","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16134318]'), work: {"id":16134318,"title":"P075 PARENTERAL GLUTAMINE PRETREATMENT REDUCES LOCAL TISSUE DAMAGE AFTER ISCHEMIA-REPERFUSION INJURY OF THE LIVER IN RATS","created_at":"2015-09-24T11:29:16.271-07:00","owner_id":35249783,"url":"https://www.academia.edu/16134318/P075_PARENTERAL_GLUTAMINE_PRETREATMENT_REDUCES_LOCAL_TISSUE_DAMAGE_AFTER_ISCHEMIA_REPERFUSION_INJURY_OF_THE_LIVER_IN_RATS","slug":"P075_PARENTERAL_GLUTAMINE_PRETREATMENT_REDUCES_LOCAL_TISSUE_DAMAGE_AFTER_ISCHEMIA_REPERFUSION_INJURY_OF_THE_LIVER_IN_RATS","dom_id":"work_16134318","summary":"Rationale: Surgical methods aimed to reduce bleeding during major hepatic resections, result in warm ischemiareperfusion (I-R) injury of the liver, which has considerable impact on the postoperative outcome. Great research work has been done to invent possible protective techniques. We aimed to investigate whether L-alanyl-L-glutamine dipeptide pretreatment administered at different time points preoperatively could reduce hepatic I-R injury, according to histological samples and serum necroenzyme levels. Methods: Male Wistar rats (n = 60), received an immediately preoperative (\"short term\" group), or a 24hrs earlier administered (\"long term\" group) Dipeptiven ® infusion and underwent normothermic, 60min, segmental liver ischemia followed by 6hrs or 24hrs of reperfusion, respectively. Histological and blood samples were taken at the end of reperfusion. Liver tissue damage was assessed by morphometric analysis, different immunohistochemical reactions and serum necroenzyme levels. The samples of pretreated animals were compared to the matching sham operated, and I-R groups. Results: Inflammatory reaction in the hematoxilyneosin stained liver samples was significantly lower in the pretreated groups and tissue integrity was more preserved, while high rate of necrosis could be seen in the control samples. In the \"short term\" group, more apoptotic cells could be observed with anti-caspase-3 reaction, while the \"long term\" pretreatment was found to reduce lipoid degeneration and tissue poly-(ADPribose) polymerase activation. Together with lower tissue damage, serum ALT and AST levels were significantly lower (p = 0.045 for \"short term\" and p = 0.038 for \"long term\" pretreatment). Conclusion: Our results suggest, that preoperative L-alanyl-L-glutamine dipeptide pretreatment, could be an effective method to prevent hepatocellular necrosis after liver I-R injury.","publication":"Clinical Nutrition Supplements","publication_with_fallback":"Clinical Nutrition Supplements","downloadable_attachments":[{"id":42685471,"asset_id":16134318,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42685471/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42685471/s1744-1161_2809_2970125-5-libre.pdf20160214-15716-mhq043?1455503195=\u0026response-content-disposition=attachment%3B+filename%3DP075_PARENTERAL_GLUTAMINE_PRETREATMENT_R.pdf\u0026Expires=1740541146\u0026Signature=IqLpCXy7JwVwH-39vc3ZEt865qvQB3nthWy35oXUFhfUWunxhn7I8nVGB9FE3hDUxypkJxp8b8Nn6LadnthKG1-yGhnbe8jbDXrKQw-w6QN3X5TLABt9XJh5aM19JR1sts~ALcKp8aKnN740YA1xP6TEhUWJ~GKkkzoQDEzMKLwd0VUkV-VQtSg1FqvX0OGjROtEU6wDPR6dz0jE9EPsll8N0C2jXlxgPx6psMI5T7jb~72ehxllBHnLKh9-khhXGD7sPdCZz7mNqVta0Xfl56X0TfCSnih5imYWQhyhsrwnOKdZ6RstqnYgT9rOp7~vty0WeUG9jXji6cV9buh9mw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42685471/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42685471/mini_magick20190217-27717-14d92td.png?1550417305"}],"downloadable_attachments_with_full_thumbnails":[{"id":42685471,"asset_id":16134318,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42685471/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42685471/s1744-1161_2809_2970125-5-libre.pdf20160214-15716-mhq043?1455503195=\u0026response-content-disposition=attachment%3B+filename%3DP075_PARENTERAL_GLUTAMINE_PRETREATMENT_R.pdf\u0026Expires=1740541147\u0026Signature=R~NoF82A-An8mA~npyAFxthpZLzQ8MkSnn-Xtc7H5FZu1KtVj7XOMLGEJb0oSncn~lQ8HyNmqu-sPU8LaZVS3DYAlt1xSxGk9U~Z5ECWJpYR3F0mYZFUpcUgIt0K2~s5gcCW9rJhm4fXK6NfbCSIBn-Dmai~Swi0~f7fc1ezCaj6KFiFglHwM1l8Kns6oQOES~iOh1UHI~5f5VbzYGQNgDpqJjaverAJwjefxKxetcLjofTJ95Z17OQD~7M2v-4Yf8wj2jvhFUHj-TJZfG495SvZMXbt0ygCyk8y4EueCw36Mq~K7GgMOALc~sGAbtWmBfzcUAJYZxC8YumJGuQUhw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42685471/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42685471/mini_magick20190217-27717-14d92td.png?1550417305"}],"has_pdf":true,"has_fulltext":true,"page_count":1,"ordered_authors":[{"id":35367123,"first_name":"Attila","last_name":"Szijártó","domain_name":"sote","page_name":"AttilaSzijártó","display_name":"Attila Szijártó","profile_url":"https://sote.academia.edu/AttilaSzij%C3%A1rt%C3%B3","photo":"/images/s65_no_pic.png"},{"id":35249783,"first_name":"Péter","last_name":"Kupcsulik","domain_name":"sote","page_name":"PéterKupcsulik","display_name":"Péter Kupcsulik","profile_url":"https://sote.academia.edu/P%C3%A9terKupcsulik","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics","nofollow":true},{"id":50948,"name":"Ischemia Reperfusion Injury","url":"https://www.academia.edu/Documents/in/Ischemia_Reperfusion_Injury","nofollow":true}],"publication_year":2009,"publication_year_with_fallback":2009,"paper_rank":null,"all_time_views":7,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16134319 coauthored" data-work_id="16134319" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16134319/P076_IMPROVING_HEPATIC_MICROCIRCULATION_AND_ANTIOXIDANT_STATE_AFTER_ISCHEMIA_REPERFUSION_INJURY_OF_THE_LIVER_BY_GLUTAMINE_PRETREATMENT_IN_RATS">P076 IMPROVING HEPATIC MICROCIRCULATION AND ANTIOXIDANT STATE AFTER ISCHEMIA REPERFUSION INJURY OF THE LIVER BY GLUTAMINE PRETREATMENT IN RATS</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Rationale: Surgical methods aimed to reduce bleeding during major hepatic resections, result in warm ischemiareperfusion (I-R) injury of the liver, which has considerable impact on the postoperative outcome. Great research work has been... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16134319" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Rationale: Surgical methods aimed to reduce bleeding during major hepatic resections, result in warm ischemiareperfusion (I-R) injury of the liver, which has considerable impact on the postoperative outcome. Great research work has been done to invent possible protective techniques. We aimed to investigate whether L-alanyl-L-glutamine dipeptide pretreatment administered at different time points preoperatively could reduce hepatic I-R injury, according to histological samples and serum necroenzyme levels. Methods: Male Wistar rats (n = 60), received an immediately preoperative ("short term" group), or a 24hrs earlier administered ("long term" group) Dipeptiven ® infusion and underwent normothermic, 60min, segmental liver ischemia followed by 6hrs or 24hrs of reperfusion, respectively. Histological and blood samples were taken at the end of reperfusion. Liver tissue damage was assessed by morphometric analysis, different immunohistochemical reactions and serum necroenzyme levels. The samples of pretreated animals were compared to the matching sham operated, and I-R groups. Results: Inflammatory reaction in the hematoxilyneosin stained liver samples was significantly lower in the pretreated groups and tissue integrity was more preserved, while high rate of necrosis could be seen in the control samples. In the "short term" group, more apoptotic cells could be observed with anti-caspase-3 reaction, while the "long term" pretreatment was found to reduce lipoid degeneration and tissue poly-(ADPribose) polymerase activation. Together with lower tissue damage, serum ALT and AST levels were significantly lower (p = 0.045 for "short term" and p = 0.038 for "long term" pretreatment). Conclusion: Our results suggest, that preoperative L-alanyl-L-glutamine dipeptide pretreatment, could be an effective method to prevent hepatocellular necrosis after liver I-R injury.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16134319" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="945b1f681e69f36e1f3d08dc97783e36" rel="nofollow" data-download="{"attachment_id":42685470,"asset_id":16134319,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42685470/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35367123" href="https://sote.academia.edu/AttilaSzij%C3%A1rt%C3%B3">Attila Szijártó</a><script data-card-contents-for-user="35367123" type="text/json">{"id":35367123,"first_name":"Attila","last_name":"Szijártó","domain_name":"sote","page_name":"AttilaSzijártó","display_name":"Attila Szijártó","profile_url":"https://sote.academia.edu/AttilaSzij%C3%A1rt%C3%B3","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16134319">+1</span><div class="hidden js-additional-users-16134319"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://sote.academia.edu/P%C3%A9terKupcsulik">Péter Kupcsulik</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16134319'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16134319').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16134319 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16134319"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16134319; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16134319]").text(description); $(".js-view-count-work_16134319").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16134319").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16134319"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="591" rel="nofollow" href="https://www.academia.edu/Documents/in/Nutrition_and_Dietetics">Nutrition and Dietetics</a>, <script data-card-contents-for-ri="591" type="text/json">{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="50948" rel="nofollow" href="https://www.academia.edu/Documents/in/Ischemia_Reperfusion_Injury">Ischemia Reperfusion Injury</a><script data-card-contents-for-ri="50948" type="text/json">{"id":50948,"name":"Ischemia Reperfusion Injury","url":"https://www.academia.edu/Documents/in/Ischemia_Reperfusion_Injury","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16134319]'), work: {"id":16134319,"title":"P076 IMPROVING HEPATIC MICROCIRCULATION AND ANTIOXIDANT STATE AFTER ISCHEMIA REPERFUSION INJURY OF THE LIVER BY GLUTAMINE PRETREATMENT IN RATS","created_at":"2015-09-24T11:29:16.936-07:00","owner_id":35249783,"url":"https://www.academia.edu/16134319/P076_IMPROVING_HEPATIC_MICROCIRCULATION_AND_ANTIOXIDANT_STATE_AFTER_ISCHEMIA_REPERFUSION_INJURY_OF_THE_LIVER_BY_GLUTAMINE_PRETREATMENT_IN_RATS","slug":"P076_IMPROVING_HEPATIC_MICROCIRCULATION_AND_ANTIOXIDANT_STATE_AFTER_ISCHEMIA_REPERFUSION_INJURY_OF_THE_LIVER_BY_GLUTAMINE_PRETREATMENT_IN_RATS","dom_id":"work_16134319","summary":"Rationale: Surgical methods aimed to reduce bleeding during major hepatic resections, result in warm ischemiareperfusion (I-R) injury of the liver, which has considerable impact on the postoperative outcome. Great research work has been done to invent possible protective techniques. We aimed to investigate whether L-alanyl-L-glutamine dipeptide pretreatment administered at different time points preoperatively could reduce hepatic I-R injury, according to histological samples and serum necroenzyme levels. Methods: Male Wistar rats (n = 60), received an immediately preoperative (\"short term\" group), or a 24hrs earlier administered (\"long term\" group) Dipeptiven ® infusion and underwent normothermic, 60min, segmental liver ischemia followed by 6hrs or 24hrs of reperfusion, respectively. Histological and blood samples were taken at the end of reperfusion. Liver tissue damage was assessed by morphometric analysis, different immunohistochemical reactions and serum necroenzyme levels. The samples of pretreated animals were compared to the matching sham operated, and I-R groups. Results: Inflammatory reaction in the hematoxilyneosin stained liver samples was significantly lower in the pretreated groups and tissue integrity was more preserved, while high rate of necrosis could be seen in the control samples. In the \"short term\" group, more apoptotic cells could be observed with anti-caspase-3 reaction, while the \"long term\" pretreatment was found to reduce lipoid degeneration and tissue poly-(ADPribose) polymerase activation. Together with lower tissue damage, serum ALT and AST levels were significantly lower (p = 0.045 for \"short term\" and p = 0.038 for \"long term\" pretreatment). Conclusion: Our results suggest, that preoperative L-alanyl-L-glutamine dipeptide pretreatment, could be an effective method to prevent hepatocellular necrosis after liver I-R injury.","publication":"Clinical Nutrition Supplements","publication_with_fallback":"Clinical Nutrition Supplements","downloadable_attachments":[{"id":42685470,"asset_id":16134319,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42685470/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42685470/s1744-1161_2809_2970126-7-libre.pdf20160214-28778-3suhps?1455503195=\u0026response-content-disposition=attachment%3B+filename%3DP076_IMPROVING_HEPATIC_MICROCIRCULATION.pdf\u0026Expires=1740541147\u0026Signature=Rkr5DVsx1jAbMByKeSldA6~6kNEu~~B0dpoWzdVG~Q~ctVm86Y1VWD5q4S58zz-t0ATeYaZ00c88SoS3jOyG8LdLLc5lPyQnhblFt1-iBAl2nJQeqtaTQqgvSmuZJl3MZ~ThPGzrtkegZPU8sTNO2ABGJqtDWlEnN8UTG~KFoapSQk-eJAIVfZTUOCbOyK9IZGLclb56wXybcp29hQZNyFhXUGbNZ98kasGqGQibewvz4Pt2kahM35omiu~dtASOSqhEIzre-LRCn6eZX63-WbavKEPWmkDHtCmzruqDQcr0l2GArA7dTeJ3Mxyh2eR0z-IMBjzHEQ7oDazsi7TaEg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42685470/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42685470/mini_magick20190217-23855-qqgm1k.png?1550417305"}],"downloadable_attachments_with_full_thumbnails":[{"id":42685470,"asset_id":16134319,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42685470/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42685470/s1744-1161_2809_2970126-7-libre.pdf20160214-28778-3suhps?1455503195=\u0026response-content-disposition=attachment%3B+filename%3DP076_IMPROVING_HEPATIC_MICROCIRCULATION.pdf\u0026Expires=1740541147\u0026Signature=Rkr5DVsx1jAbMByKeSldA6~6kNEu~~B0dpoWzdVG~Q~ctVm86Y1VWD5q4S58zz-t0ATeYaZ00c88SoS3jOyG8LdLLc5lPyQnhblFt1-iBAl2nJQeqtaTQqgvSmuZJl3MZ~ThPGzrtkegZPU8sTNO2ABGJqtDWlEnN8UTG~KFoapSQk-eJAIVfZTUOCbOyK9IZGLclb56wXybcp29hQZNyFhXUGbNZ98kasGqGQibewvz4Pt2kahM35omiu~dtASOSqhEIzre-LRCn6eZX63-WbavKEPWmkDHtCmzruqDQcr0l2GArA7dTeJ3Mxyh2eR0z-IMBjzHEQ7oDazsi7TaEg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42685470/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42685470/mini_magick20190217-23855-qqgm1k.png?1550417305"}],"has_pdf":true,"has_fulltext":true,"page_count":1,"ordered_authors":[{"id":35367123,"first_name":"Attila","last_name":"Szijártó","domain_name":"sote","page_name":"AttilaSzijártó","display_name":"Attila Szijártó","profile_url":"https://sote.academia.edu/AttilaSzij%C3%A1rt%C3%B3","photo":"/images/s65_no_pic.png"},{"id":35249783,"first_name":"Péter","last_name":"Kupcsulik","domain_name":"sote","page_name":"PéterKupcsulik","display_name":"Péter Kupcsulik","profile_url":"https://sote.academia.edu/P%C3%A9terKupcsulik","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics","nofollow":true},{"id":50948,"name":"Ischemia Reperfusion Injury","url":"https://www.academia.edu/Documents/in/Ischemia_Reperfusion_Injury","nofollow":true}],"publication_year":2009,"publication_year_with_fallback":2009,"paper_rank":null,"all_time_views":11,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16134327 coauthored" data-work_id="16134327" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16134327/Ascorbate_mediated_electron_transfer_in_protein_thiol_oxidation_in_the_endoplasmic_reticulum">Ascorbate-mediated electron transfer in protein thiol oxidation in the endoplasmic reticulum</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Addition of, or gulonolactone oxidase-dependent in situ generation of, ascorbate provoked the oxidation of protein thiols, which was accompanied by ascorbate consumption in liver microsomal vesicles. The maximal rate of protein thiol... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16134327" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Addition of, or gulonolactone oxidase-dependent in situ generation of, ascorbate provoked the oxidation of protein thiols, which was accompanied by ascorbate consumption in liver microsomal vesicles. The maximal rate of protein thiol oxidation was similar upon gulonolactone, ascorbate or dehydroascorbate addition. Cytochrome P450 inhibitors (econazole, proadifen, quercetin) decreased ascorbate consumption and the gulonolactone or ascorbate-stimulated thiol oxidation. The results demonstrate that the ascorbate/dehydroascorbate redox couple plays an important role in electron transfer from protein thiols to oxygen in the hepatic endoplasmic reticulum, even in gulonolactone oxidase deficient species.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16134327" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1673092cc0a78cdc74d52be3077abe86" rel="nofollow" data-download="{"attachment_id":42685464,"asset_id":16134327,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42685464/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35249783" href="https://sote.academia.edu/P%C3%A9terKupcsulik">Péter Kupcsulik</a><script data-card-contents-for-user="35249783" type="text/json">{"id":35249783,"first_name":"Péter","last_name":"Kupcsulik","domain_name":"sote","page_name":"PéterKupcsulik","display_name":"Péter Kupcsulik","profile_url":"https://sote.academia.edu/P%C3%A9terKupcsulik","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16134327">+1</span><div class="hidden js-additional-users-16134327"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://bme.academia.edu/Andr%C3%A1sSzarka">András Szarka</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16134327'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16134327').html(); 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coauthored" data-work_id="16134334" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16134334/Comparison_of_early_and_1_year_follow_up_results_of_conventional_hemorrhoidectomy_and_hemorrhoid_artery_ligation_a_randomized_study">Comparison of early and 1-year follow-up results of conventional hemorrhoidectomy and hemorrhoid artery ligation: a randomized study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background and aims Doppler-guided hemorrhoid artery ligation is a new approach for treating hemorrhoids. Early and 1-year follow-up results of the procedure are presented and compared with those of closed scissors hemorrhoidectomy in a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16134334" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background and aims Doppler-guided hemorrhoid artery ligation is a new approach for treating hemorrhoids. Early and 1-year follow-up results of the procedure are presented and compared with those of closed scissors hemorrhoidectomy in a prospective randomized study.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16134334" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="35cdfa3d39da696af25c4bef536a8fbc" rel="nofollow" data-download="{"attachment_id":42685468,"asset_id":16134334,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42685468/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35324997" href="https://independent.academia.edu/LFlautner">L. 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These data suggest that SCCA overexpression is an early event in hepatocarcinogenesis. According to their non-neoplastic significance, MRNs do not express... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16134336" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">sociated with HCCs (78%) and DNs (100%) than in cases associated with MRNs (22%). These data suggest that SCCA overexpression is an early event in hepatocarcinogenesis. According to their non-neoplastic significance, MRNs do not express SCCA.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16134336" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fa83e2395c24d64b36dcd0921158c460" rel="nofollow" data-download="{"attachment_id":42685461,"asset_id":16134336,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42685461/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35249783" href="https://sote.academia.edu/P%C3%A9terKupcsulik">Péter Kupcsulik</a><script data-card-contents-for-user="35249783" type="text/json">{"id":35249783,"first_name":"Péter","last_name":"Kupcsulik","domain_name":"sote","page_name":"PéterKupcsulik","display_name":"Péter Kupcsulik","profile_url":"https://sote.academia.edu/P%C3%A9terKupcsulik","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16134336 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16134336"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16134336, container: ".js-paper-rank-work_16134336", }); 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These data suggest that SCCA overexpression is an early event in hepatocarcinogenesis. According to their non-neoplastic significance, MRNs do not express SCCA.","publication":"Journal of Hepatology","publication_with_fallback":"Journal of Hepatology","downloadable_attachments":[{"id":42685461,"asset_id":16134336,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42685461/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42685461/s0168-8278_2804_2990253-x-libre.pdf20160214-28778-4765q2?1455503196=\u0026response-content-disposition=attachment%3B+filename%3D253_Markedly_downregulated_claudin_4_exp.pdf\u0026Expires=1740363506\u0026Signature=e2LdDEw5erJUY8VXY2R2kUNf-sw2XskpP6W3EfU2WMBDBTWFZvskui-mNhhVmKn1n6slBOHt6e8Y~zfdavVxXDYokq6A1XuyFS8CDN3lEzIoSRog8BzcVSHEP1VxcIyRrKVzf-aZ2rKlwgJ1uZlFuwXOFeBDDgM2~onqb7jMY6QGwULx8ZKEwHTm~nT3QUatbnGHChfTxkWwOyXmorP~1pvMkfY36IZ8RJum1H2z53aMoaltlNDejEnNkoxglCPLTYZrH~VOm-~IDuqox66xXOYFNAKVoHhsj7QdAO8QASl~nH~gAInqFSC3LFUb7lwsVwgw5dhaL9Q2dhpJYA0rSw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42685461/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42685461/mini_magick20190217-32373-14buk9k.png?1550417321"}],"downloadable_attachments_with_full_thumbnails":[{"id":42685461,"asset_id":16134336,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42685461/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42685461/s0168-8278_2804_2990253-x-libre.pdf20160214-28778-4765q2?1455503196=\u0026response-content-disposition=attachment%3B+filename%3D253_Markedly_downregulated_claudin_4_exp.pdf\u0026Expires=1740363506\u0026Signature=e2LdDEw5erJUY8VXY2R2kUNf-sw2XskpP6W3EfU2WMBDBTWFZvskui-mNhhVmKn1n6slBOHt6e8Y~zfdavVxXDYokq6A1XuyFS8CDN3lEzIoSRog8BzcVSHEP1VxcIyRrKVzf-aZ2rKlwgJ1uZlFuwXOFeBDDgM2~onqb7jMY6QGwULx8ZKEwHTm~nT3QUatbnGHChfTxkWwOyXmorP~1pvMkfY36IZ8RJum1H2z53aMoaltlNDejEnNkoxglCPLTYZrH~VOm-~IDuqox66xXOYFNAKVoHhsj7QdAO8QASl~nH~gAInqFSC3LFUb7lwsVwgw5dhaL9Q2dhpJYA0rSw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42685461/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42685461/mini_magick20190217-32373-14buk9k.png?1550417321"}],"has_pdf":true,"has_fulltext":true,"page_count":2,"ordered_authors":[{"id":35249783,"first_name":"Péter","last_name":"Kupcsulik","domain_name":"sote","page_name":"PéterKupcsulik","display_name":"Péter Kupcsulik","profile_url":"https://sote.academia.edu/P%C3%A9terKupcsulik","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":37773,"name":"Hepatology","url":"https://www.academia.edu/Documents/in/Hepatology","nofollow":true},{"id":111972,"name":"Hepatocellular Carcinoma","url":"https://www.academia.edu/Documents/in/Hepatocellular_Carcinoma","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences","nofollow":true}],"publication_year":2004,"publication_year_with_fallback":2004,"paper_rank":null,"all_time_views":10,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16134337" data-work_id="16134337" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16134337/313_Different_claudin_4_expression_in_biliary_and_hepatocellular_carcinomas">313 Different claudin-4 expression in biliary and hepatocellular carcinomas</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">$121 liver, allowed to adhere in culture and submitted to a catalytic system, which reduces oxygen concentration to less than 1% within 30 minutes. Gene expressions were assessed by quantitative real-time RT-PCR. Results: In vivo, 24... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16134337" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">$121 liver, allowed to adhere in culture and submitted to a catalytic system, which reduces oxygen concentration to less than 1% within 30 minutes. Gene expressions were assessed by quantitative real-time RT-PCR. Results: In vivo, 24 hours after the onset of arterial liver ischemia in rats, cholestatic changes in serum were detected together with a decrease in bile flow and in bile acid and bicarbonate output in bile. No regurgitation of fluorescent ursodeoxycholic acid was detected, eliminating bile duct leakage as a major mechanism of cholestasis in this model. VEGF, a hypoxia-regulated gene, was induced in both hepatocytes and cholangiocytes, as ascertained by immunohistochemistry. Concomitantly, hepatic mRNA levels of ntcp, bsep and mrp2 were significantly reduced (by 70%, 50% and 70%, respectively), whereas Cftr mRNA levels were increased (by more than 4 fold), even though ductular reaction was not yet present at this time. In vitro, hypoxia caused a decrease in ntcp, bsep and mrp2 transcripts in hepatocytes (by 70%, 80% and 70%, respectively), and an increase in cftr transcripts (by 3 fold), associated with a rise in cAMP (by more than 10 fold) in cholangiocytes. Conclusion: These results demonstrate that hypoxia induces differential regulations in the expression of hepatobiliary transporters. The downregulation of transporters involved in bile salt-dependent and -independent secretion in hepatocytes may contribute to cholestasis. By contrast the upregulation of CFTR in cholangiocytes may, together with increased cAME a major regulator of CFTR expression and activity, and with subsequent ductular proliferation, provide a defense mechanism.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16134337" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ff457b16910853b9c7fa7a1e45d299d4" rel="nofollow" data-download="{"attachment_id":42685462,"asset_id":16134337,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42685462/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35249783" href="https://sote.academia.edu/P%C3%A9terKupcsulik">Péter Kupcsulik</a><script data-card-contents-for-user="35249783" type="text/json">{"id":35249783,"first_name":"Péter","last_name":"Kupcsulik","domain_name":"sote","page_name":"PéterKupcsulik","display_name":"Péter Kupcsulik","profile_url":"https://sote.academia.edu/P%C3%A9terKupcsulik","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16134337 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16134337"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16134337, container: ".js-paper-rank-work_16134337", }); 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Gene expressions were assessed by quantitative real-time RT-PCR. Results: In vivo, 24 hours after the onset of arterial liver ischemia in rats, cholestatic changes in serum were detected together with a decrease in bile flow and in bile acid and bicarbonate output in bile. No regurgitation of fluorescent ursodeoxycholic acid was detected, eliminating bile duct leakage as a major mechanism of cholestasis in this model. VEGF, a hypoxia-regulated gene, was induced in both hepatocytes and cholangiocytes, as ascertained by immunohistochemistry. Concomitantly, hepatic mRNA levels of ntcp, bsep and mrp2 were significantly reduced (by 70%, 50% and 70%, respectively), whereas Cftr mRNA levels were increased (by more than 4 fold), even though ductular reaction was not yet present at this time. In vitro, hypoxia caused a decrease in ntcp, bsep and mrp2 transcripts in hepatocytes (by 70%, 80% and 70%, respectively), and an increase in cftr transcripts (by 3 fold), associated with a rise in cAMP (by more than 10 fold) in cholangiocytes. Conclusion: These results demonstrate that hypoxia induces differential regulations in the expression of hepatobiliary transporters. The downregulation of transporters involved in bile salt-dependent and -independent secretion in hepatocytes may contribute to cholestasis. By contrast the upregulation of CFTR in cholangiocytes may, together with increased cAME a major regulator of CFTR expression and activity, and with subsequent ductular proliferation, provide a defense mechanism.","publication":"Journal of Hepatology","publication_with_fallback":"Journal of Hepatology","downloadable_attachments":[{"id":42685462,"asset_id":16134337,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42685462/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42685462/s0168-8278_2806_2980314-4-libre.pdf20160214-10406-u2b47z?1455503195=\u0026response-content-disposition=attachment%3B+filename%3D313_Different_claudin_4_expression_in_bi.pdf\u0026Expires=1740541147\u0026Signature=BntuSrpNHnzl0iA3LZYoy5MoZFqFf4gSZlqs~Q854rhK9jpiA3aEYJCq6ByFohCdWmrc9Si6pjSybELCylXAFhlwJdlpNPbSLyYDv6iD1L0sZd-3LFMi8pcRa2-AexMq-Jzj5BJuqeNv~833kH6vavp9MkiWL7oqmip-ND6agM8WrfSSRErSDj4PUinpeAM4zbWudUU2AyeFaFjK6PQvzBHZ2LgHLLqQs6ioOZV4bnUA4x-1vi04vstuMJk9j2uJyCM2ahmSkF8hOFCgLRDRmVKDbA0EizL2xElWLjbhndXq3cYlMxKGZJcqKRrNYWT~qAUe98a2DNS6tCZ2uP-5nA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42685462/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42685462/mini_magick20190217-23852-1hgu3we.png?1550417308"}],"downloadable_attachments_with_full_thumbnails":[{"id":42685462,"asset_id":16134337,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42685462/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42685462/s0168-8278_2806_2980314-4-libre.pdf20160214-10406-u2b47z?1455503195=\u0026response-content-disposition=attachment%3B+filename%3D313_Different_claudin_4_expression_in_bi.pdf\u0026Expires=1740541147\u0026Signature=BntuSrpNHnzl0iA3LZYoy5MoZFqFf4gSZlqs~Q854rhK9jpiA3aEYJCq6ByFohCdWmrc9Si6pjSybELCylXAFhlwJdlpNPbSLyYDv6iD1L0sZd-3LFMi8pcRa2-AexMq-Jzj5BJuqeNv~833kH6vavp9MkiWL7oqmip-ND6agM8WrfSSRErSDj4PUinpeAM4zbWudUU2AyeFaFjK6PQvzBHZ2LgHLLqQs6ioOZV4bnUA4x-1vi04vstuMJk9j2uJyCM2ahmSkF8hOFCgLRDRmVKDbA0EizL2xElWLjbhndXq3cYlMxKGZJcqKRrNYWT~qAUe98a2DNS6tCZ2uP-5nA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42685462/download_file?st=MTc0MDUzNzU0Nyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42685462/mini_magick20190217-23852-1hgu3we.png?1550417308"}],"has_pdf":true,"has_fulltext":true,"page_count":1,"ordered_authors":[{"id":35249783,"first_name":"Péter","last_name":"Kupcsulik","domain_name":"sote","page_name":"PéterKupcsulik","display_name":"Péter Kupcsulik","profile_url":"https://sote.academia.edu/P%C3%A9terKupcsulik","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":37773,"name":"Hepatology","url":"https://www.academia.edu/Documents/in/Hepatology","nofollow":true},{"id":111972,"name":"Hepatocellular Carcinoma","url":"https://www.academia.edu/Documents/in/Hepatocellular_Carcinoma","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences","nofollow":true}],"publication_year":2006,"publication_year_with_fallback":2006,"paper_rank":null,"all_time_views":8,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16134338 coauthored" data-work_id="16134338" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16134338/_431_HUMAN_HEPATOCELLULAR_CARCINOMA_IS_CHARACTERIZED_BY_DIFFERENT_CLAUDIN_EXPRESSION_PATTERN_WITH_RESPECT_TO_CIRRHOSIS_AND_HCV_INFECTION">[431] HUMAN HEPATOCELLULAR CARCINOMA IS CHARACTERIZED BY DIFFERENT CLAUDIN EXPRESSION PATTERN WITH RESPECT TO CIRRHOSIS AND HCV INFECTION</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background and Aims: Tight junction proteins as claudins (CLDNs) are widely implicated in carcinogenesis. Claudins (1-24) have been recently identified as integral proteins of tight junction strands. Claudin-10 expression was found... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16134338" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background and Aims: Tight junction proteins as claudins (CLDNs) are widely implicated in carcinogenesis. Claudins (1-24) have been recently identified as integral proteins of tight junction strands. Claudin-10 expression was found associated with recurrence of primary hepatocellular carcinoma (HCC). The objective was to characterize the expression of claudin-1-4, -7-8, -10, -14, -17 and -23 in human HCCs, surrounding and normal livers. Methods: 25 surgically resected HCCs with surrounding tissues and ten normal livers were examined by real-time RT-PCR and immunohistochemistry. Tmmunoreactivity of CLDNs were quantified by morphometry. Results: CLDN-2 and -4 mRNA levels were significantly decreased (5.2folds and 4.4-folds, respectively) in HCCs compared to normal liver. CLDN-2 and CLDN-I0 expression revealed significant differences in comparison to surrounding liver (5.1 -folds and 3 1.3-folds). HCV infection resulted in significant decrease of CLDN-1 and CLDN-2 in the surrounding liver compared to the virus negative sample group: 1.8-folds and 2.20-folds. Cirrhosis associated HCCs showed significant upregulation of CLDN-I (1.94-folds) and downregulation of CLDN-8 (30.5-folds) compared to HCCs with non-cirrhotic surrounding liver. Immunohistochemistry revealed membranous pattern for CLDN-1, -3, -7 and cytoplasmic staining for CLDN-2, while CLDN-4, -8, -10, -14, -17 and -23 was not detected on HCC cells. Morphometry revealed significantly higher CLDN-I, -3 and -7 expression while CLDN-2 and CLDN-4 expression was found decreased in HCCs compared to surrounding and normal liver, respectively. HCV infection resulted in significant decrease of CLDN-3 expression in surrounding liver compared to HCV negative surrounding tissue. Significant decrease of CLDN-3 level was also found in HCV positive HCCs compared to HCV negative ones. Cirrhotic surrounding livers showed significantly higher expression of CLDN-1 compared to noncirrhotic surrounding livers. HCCs developed on the basis of cirrhosis also revealed significantly increased expression of CLDN-1 compared to HCCs with non-cirrhotic surrounding liver, Conclusions: Cirrhosis may increase the expression of claudin-I. HCV infection results in decreased expression of certain claudins in HCC and surrounding liver which may implicate that HCV alters intercellular connections. Further, biological role and significance of downregulated claudin-2, -4, -8 and -1 0 expression should be elucidated. The project was supported by grants:</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16134338" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b6a33739021aa982ae036c4eebabe1ca" rel="nofollow" data-download="{"attachment_id":42685463,"asset_id":16134338,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42685463/download_file?st=MTc0MDUzNzU0OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35367123" href="https://sote.academia.edu/AttilaSzij%C3%A1rt%C3%B3">Attila Szijártó</a><script data-card-contents-for-user="35367123" type="text/json">{"id":35367123,"first_name":"Attila","last_name":"Szijártó","domain_name":"sote","page_name":"AttilaSzijártó","display_name":"Attila Szijártó","profile_url":"https://sote.academia.edu/AttilaSzij%C3%A1rt%C3%B3","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16134338">+1</span><div class="hidden js-additional-users-16134338"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://sote.academia.edu/P%C3%A9terKupcsulik">Péter Kupcsulik</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16134338'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16134338').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16134338 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16134338"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16134338; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16134338]").text(description); $(".js-view-count-work_16134338").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16134338").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16134338"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="37773" rel="nofollow" href="https://www.academia.edu/Documents/in/Hepatology">Hepatology</a>, <script data-card-contents-for-ri="37773" type="text/json">{"id":37773,"name":"Hepatology","url":"https://www.academia.edu/Documents/in/Hepatology","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="111972" rel="nofollow" href="https://www.academia.edu/Documents/in/Hepatocellular_Carcinoma">Hepatocellular Carcinoma</a>, <script data-card-contents-for-ri="111972" type="text/json">{"id":111972,"name":"Hepatocellular Carcinoma","url":"https://www.academia.edu/Documents/in/Hepatocellular_Carcinoma","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16134338]'), work: {"id":16134338,"title":"[431] HUMAN HEPATOCELLULAR CARCINOMA IS CHARACTERIZED BY DIFFERENT CLAUDIN EXPRESSION PATTERN WITH RESPECT TO CIRRHOSIS AND HCV INFECTION","created_at":"2015-09-24T11:29:19.441-07:00","owner_id":35249783,"url":"https://www.academia.edu/16134338/_431_HUMAN_HEPATOCELLULAR_CARCINOMA_IS_CHARACTERIZED_BY_DIFFERENT_CLAUDIN_EXPRESSION_PATTERN_WITH_RESPECT_TO_CIRRHOSIS_AND_HCV_INFECTION","slug":"_431_HUMAN_HEPATOCELLULAR_CARCINOMA_IS_CHARACTERIZED_BY_DIFFERENT_CLAUDIN_EXPRESSION_PATTERN_WITH_RESPECT_TO_CIRRHOSIS_AND_HCV_INFECTION","dom_id":"work_16134338","summary":"Background and Aims: Tight junction proteins as claudins (CLDNs) are widely implicated in carcinogenesis. Claudins (1-24) have been recently identified as integral proteins of tight junction strands. Claudin-10 expression was found associated with recurrence of primary hepatocellular carcinoma (HCC). The objective was to characterize the expression of claudin-1-4, -7-8, -10, -14, -17 and -23 in human HCCs, surrounding and normal livers. Methods: 25 surgically resected HCCs with surrounding tissues and ten normal livers were examined by real-time RT-PCR and immunohistochemistry. Tmmunoreactivity of CLDNs were quantified by morphometry. Results: CLDN-2 and -4 mRNA levels were significantly decreased (5.2folds and 4.4-folds, respectively) in HCCs compared to normal liver. CLDN-2 and CLDN-I0 expression revealed significant differences in comparison to surrounding liver (5.1 -folds and 3 1.3-folds). HCV infection resulted in significant decrease of CLDN-1 and CLDN-2 in the surrounding liver compared to the virus negative sample group: 1.8-folds and 2.20-folds. Cirrhosis associated HCCs showed significant upregulation of CLDN-I (1.94-folds) and downregulation of CLDN-8 (30.5-folds) compared to HCCs with non-cirrhotic surrounding liver. Immunohistochemistry revealed membranous pattern for CLDN-1, -3, -7 and cytoplasmic staining for CLDN-2, while CLDN-4, -8, -10, -14, -17 and -23 was not detected on HCC cells. Morphometry revealed significantly higher CLDN-I, -3 and -7 expression while CLDN-2 and CLDN-4 expression was found decreased in HCCs compared to surrounding and normal liver, respectively. HCV infection resulted in significant decrease of CLDN-3 expression in surrounding liver compared to HCV negative surrounding tissue. Significant decrease of CLDN-3 level was also found in HCV positive HCCs compared to HCV negative ones. Cirrhotic surrounding livers showed significantly higher expression of CLDN-1 compared to noncirrhotic surrounding livers. HCCs developed on the basis of cirrhosis also revealed significantly increased expression of CLDN-1 compared to HCCs with non-cirrhotic surrounding liver, Conclusions: Cirrhosis may increase the expression of claudin-I. HCV infection results in decreased expression of certain claudins in HCC and surrounding liver which may implicate that HCV alters intercellular connections. Further, biological role and significance of downregulated claudin-2, -4, -8 and -1 0 expression should be elucidated. The project was supported by grants:","publication":"Journal of Hepatology","publication_with_fallback":"Journal of 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Szijártó","profile_url":"https://sote.academia.edu/AttilaSzij%C3%A1rt%C3%B3","photo":"/images/s65_no_pic.png"},{"id":35249783,"first_name":"Péter","last_name":"Kupcsulik","domain_name":"sote","page_name":"PéterKupcsulik","display_name":"Péter Kupcsulik","profile_url":"https://sote.academia.edu/P%C3%A9terKupcsulik","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":37773,"name":"Hepatology","url":"https://www.academia.edu/Documents/in/Hepatology","nofollow":true},{"id":111972,"name":"Hepatocellular Carcinoma","url":"https://www.academia.edu/Documents/in/Hepatocellular_Carcinoma","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences","nofollow":true}],"publication_year":2007,"publication_year_with_fallback":2007,"paper_rank":null,"all_time_views":9,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16134339 coauthored" data-work_id="16134339" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16134339/Claudin_1_2_3_4_7_8_and_10_Protein_Expression_in_Biliary_Tract_Cancers">Claudin-1, -2, -3, -4, -7, -8, and -10 Protein Expression in Biliary Tract Cancers</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16134339" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a 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data-card-contents-for-user="35367123" type="text/json">{"id":35367123,"first_name":"Attila","last_name":"Szijártó","domain_name":"sote","page_name":"AttilaSzijártó","display_name":"Attila Szijártó","profile_url":"https://sote.academia.edu/AttilaSzij%C3%A1rt%C3%B3","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16134339">+1</span><div class="hidden js-additional-users-16134339"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://sote.academia.edu/P%C3%A9terKupcsulik">Péter Kupcsulik</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16134339'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16134339').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_16134339 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16134339"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16134339, container: ".js-paper-rank-work_16134339", }); });</script></li><li class="js-percentile-work_16134339 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16134339; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16134339"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); 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u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="11298" rel="nofollow" href="https://www.academia.edu/Documents/in/Membrane_Proteins">Membrane Proteins</a>, <script data-card-contents-for-ri="11298" type="text/json">{"id":11298,"name":"Membrane Proteins","url":"https://www.academia.edu/Documents/in/Membrane_Proteins","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12071" rel="nofollow" href="https://www.academia.edu/Documents/in/Immunohistochemistry">Immunohistochemistry</a>, <script data-card-contents-for-ri="12071" type="text/json">{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="501806" rel="nofollow" href="https://www.academia.edu/Documents/in/Protein_Expression">Protein Expression</a>, <script data-card-contents-for-ri="501806" type="text/json">{"id":501806,"name":"Protein Expression","url":"https://www.academia.edu/Documents/in/Protein_Expression","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1371582" rel="nofollow" href="https://www.academia.edu/Documents/in/Tight_Junction">Tight Junction</a><script data-card-contents-for-ri="1371582" type="text/json">{"id":1371582,"name":"Tight Junction","url":"https://www.academia.edu/Documents/in/Tight_Junction","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16134339]'), work: {"id":16134339,"title":"Claudin-1, -2, -3, -4, -7, -8, and -10 Protein Expression in Biliary Tract 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