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href="#Cornelia_de_Lange_syndrome"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Cornelia de Lange syndrome</span> </div> </a> <ul id="toc-Cornelia_de_Lange_syndrome-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Role_in_Basement_Membrane" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Role_in_Basement_Membrane"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Role in Basement Membrane</span> </div> </a> <ul id="toc-Role_in_Basement_Membrane-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button 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hreflang="tt" data-title="SMC3" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/SMC3" title="SMC3 – Ukrainian" lang="uk" hreflang="uk" data-title="SMC3" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q18033850#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs 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class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"><span class="mw-redirectedfrom">(Redirected from <a href="/w/index.php?title=SMC3_(gene)&redirect=no" class="mw-redirect" title="SMC3 (gene)">SMC3 (gene)</a>)</span></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in humans</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">SMC3</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q9CW03%20or%20Q9UQE7">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q9CW03,Q9UQE7">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2WD5">2WD5</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/2468">SMC3</a></span>, BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1, structural maintenance of chromosomes 3</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/606062">606062</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1339795">1339795</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=3974">3974</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=SMC3">SMC3</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000108055">SMC3 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_10.svg" class="mw-file-description" title="Chromosome 10 (human)"><img alt="Chromosome 10 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/300px-Ideogram_human_chromosome_10.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/450px-Ideogram_human_chromosome_10.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/600px-Ideogram_human_chromosome_10.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_10_(human)" class="mw-redirect" title="Chromosome 10 (human)">Chromosome 10 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_10_ideogram.svg" class="mw-file-description" title="Chromosome 10 (human)"><img alt="Chromosome 10 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/300px-Human_chromosome_10_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/450px-Human_chromosome_10_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/600px-Human_chromosome_10_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 237.70833712888px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for SMC3"><img alt="Genomic location for SMC3" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 243.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for SMC3"><img alt="Genomic location for SMC3" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">10q25.2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">110,567,684 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">110,606,048 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (mouse)"><img alt="Chromosome 19 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/260px-Ideogram_house_mouse_chromosome_19.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/390px-Ideogram_house_mouse_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/520px-Ideogram_house_mouse_chromosome_19.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 19 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (mouse)"><img alt="Chromosome 19 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/300px-Ideogram_of_house_mouse_chromosome_19.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/450px-Ideogram_of_house_mouse_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/600px-Ideogram_of_house_mouse_chromosome_19.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 251.29109149836px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for SMC3"><img alt="Genomic location for SMC3" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 257.3px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for SMC3"><img alt="Genomic location for SMC3" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">19|19 D2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">53,588,829 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">53,634,264 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000108055">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">tendon of biceps brachii</li><br /><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">oocyte</li><br /><li style="line-height: 137%;">testicle</li><br /><li style="line-height: 137%;">gonad</li><br /><li style="line-height: 137%;">ganglionic eminence</li><br /><li style="line-height: 137%;">internal globus pallidus</li><br /><li style="line-height: 137%;">Achilles tendon</li><br /><li style="line-height: 137%;">secondary oocyte</li><br /><li style="line-height: 137%;">superior surface of tongue</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000024974">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">genital tubercle</li><br /><li style="line-height: 137%;">tail of embryo</li><br /><li style="line-height: 137%;">fetal liver hematopoietic progenitor cell</li><br /><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">mandibular prominence</li><br /><li style="line-height: 137%;">maxillary prominence</li><br /><li style="line-height: 137%;">epiblast</li><br /><li style="line-height: 137%;">hand</li><br /><li style="line-height: 137%;">secondary oocyte</li><br /><li style="line-height: 137%;">somite</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000108055">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_SMC3_209259_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cd/PBB_GE_SMC3_209259_s_at_fs.png/250px-PBB_GE_SMC3_209259_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cd/PBB_GE_SMC3_209259_s_at_fs.png/375px-PBB_GE_SMC3_209259_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/cd/PBB_GE_SMC3_209259_s_at_fs.png/500px-PBB_GE_SMC3_209259_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_SMC3_209258_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/ec/PBB_GE_SMC3_209258_s_at_fs.png/250px-PBB_GE_SMC3_209258_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/ec/PBB_GE_SMC3_209258_s_at_fs.png/375px-PBB_GE_SMC3_209258_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/ec/PBB_GE_SMC3_209258_s_at_fs.png/500px-PBB_GE_SMC3_209258_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_SMC3_209257_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4b/PBB_GE_SMC3_209257_s_at_fs.png/250px-PBB_GE_SMC3_209257_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4b/PBB_GE_SMC3_209257_s_at_fs.png/375px-PBB_GE_SMC3_209257_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4b/PBB_GE_SMC3_209257_s_at_fs.png/500px-PBB_GE_SMC3_209257_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/9126/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003777">microtubule motor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000166">nucleotide binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0036033">mediator complex binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003682">chromatin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046982">protein heterodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005524">ATP binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070840">dynein complex binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048487">beta-tubulin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044877">protein-containing complex binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030893">meiotic cohesin complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016363">nuclear matrix</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005694">chromosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000800">lateral element</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000785">chromatin</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000775">chromosome, centromeric region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005604">basement membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005622">intracellular anatomical structure</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008278">cohesin complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0097431">mitotic spindle pole</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006275">regulation of DNA replication</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051276">chromosome organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006974">cellular response to DNA damage stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019827">stem cell population maintenance</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051301">cell division</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032876">negative regulation of DNA endoreduplication</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007049">cell cycle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006281">DNA repair</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007062">sister chromatid cohesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000278">mitotic cell cycle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051321">meiosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1901673">regulation of mitotic spindle assembly</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=9126&rn=1">9126</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=13006&rn=1">13006</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000108055;db=core">ENSG00000108055</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000024974;db=core">ENSMUSG00000024974</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9UQE7">Q9UQE7</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9CW03">Q9CW03</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_005445">NM_005445</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007790">NM_007790</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_005436">NP_005436</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_031816">NP_031816</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr10:110567684-110606048">Chr 10: 110.57 – 110.61 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr19:53588829-53634264">Chr 19: 53.59 – 53.63 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18033850" class="extiw" title="d:Q18033850">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18248563" class="extiw" title="d:Q18248563">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Structural maintenance of chromosomes protein 3</b> (SMC3) is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <b>SMC3</b> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-entrez_5-0" class="reference"><a href="#cite_note-entrez-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> SMC3 is a subunit of the <a href="/wiki/Cohesin" title="Cohesin">Cohesin</a> complex which mediates <a href="/wiki/Establishment_of_sister_chromatid_cohesion" title="Establishment of sister chromatid cohesion">sister chromatid cohesion</a>, homologous recombination and <a href="/wiki/Topologically_associating_domain" title="Topologically associating domain">DNA looping</a>. Cohesin is formed of SMC3, <a href="/wiki/SMC1A" title="SMC1A">SMC1</a>, <a href="/wiki/RAD21" title="RAD21">RAD21</a> and either <a href="/wiki/STAG1" title="STAG1">SA1</a> or <a href="/wiki/STAG2" title="STAG2">SA2</a>. In humans, SMC3 is present in all cohesin complexes whereas there are multiple <a href="/wiki/Sequence_homology" title="Sequence homology">paralogs</a> for the other subunits. </p><p>SMC3 is a member of the <a href="/wiki/SMC_protein" title="SMC protein">SMC protein family</a>. Members of this family are key regulators of DNA repair, chromosome condensation and chromosome segregation. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure_and_interactions">Structure and interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SMC3&action=edit&section=1" title="Edit section: Structure and interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Structure_of_the_interface_between_SMC3_(blue)_and_SMC1_(green)_(PDB_2WD5)_from_mice_(Kurze_et_al._2009).png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e8/Structure_of_the_interface_between_SMC3_%28blue%29_and_SMC1_%28green%29_%28PDB_2WD5%29_from_mice_%28Kurze_et_al._2009%29.png/220px-Structure_of_the_interface_between_SMC3_%28blue%29_and_SMC1_%28green%29_%28PDB_2WD5%29_from_mice_%28Kurze_et_al._2009%29.png" decoding="async" width="220" height="220" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e8/Structure_of_the_interface_between_SMC3_%28blue%29_and_SMC1_%28green%29_%28PDB_2WD5%29_from_mice_%28Kurze_et_al._2009%29.png/330px-Structure_of_the_interface_between_SMC3_%28blue%29_and_SMC1_%28green%29_%28PDB_2WD5%29_from_mice_%28Kurze_et_al._2009%29.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e8/Structure_of_the_interface_between_SMC3_%28blue%29_and_SMC1_%28green%29_%28PDB_2WD5%29_from_mice_%28Kurze_et_al._2009%29.png/440px-Structure_of_the_interface_between_SMC3_%28blue%29_and_SMC1_%28green%29_%28PDB_2WD5%29_from_mice_%28Kurze_et_al._2009%29.png 2x" data-file-width="1060" data-file-height="1060" /></a><figcaption>Structure of the interface between SMC3 (blue) and SMC1 (green) (PDB 2WD5) from mice (Kurze et al., 2009)</figcaption></figure> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Structure_of_the_SMC3_(blue)-RAD21_(green)_interface_(PDB_4UX3).png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Structure_of_the_SMC3_%28blue%29-RAD21_%28green%29_interface_%28PDB_4UX3%29.png/220px-Structure_of_the_SMC3_%28blue%29-RAD21_%28green%29_interface_%28PDB_4UX3%29.png" decoding="async" width="220" height="145" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Structure_of_the_SMC3_%28blue%29-RAD21_%28green%29_interface_%28PDB_4UX3%29.png/330px-Structure_of_the_SMC3_%28blue%29-RAD21_%28green%29_interface_%28PDB_4UX3%29.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/54/Structure_of_the_SMC3_%28blue%29-RAD21_%28green%29_interface_%28PDB_4UX3%29.png/440px-Structure_of_the_SMC3_%28blue%29-RAD21_%28green%29_interface_%28PDB_4UX3%29.png 2x" data-file-width="1648" data-file-height="1084" /></a><figcaption>Structure of the interface between SMC3 (blue) and RAD21 (green) (PDB 4UX3) from budding yeast (Gligoris et al., 2014)</figcaption></figure> <p>The domain organisation of SMC proteins is evolutionarily conserved and is composed of an N-terminal <a href="/wiki/Walker_motifs" title="Walker motifs">Walker A motif</a>, coiled-coil, "hinge", coiled-coil and a C-terminal <a href="/wiki/Walker_motifs" title="Walker motifs">Walker B motif</a>. The protein folds back on itself to form a rod-shaped molecule with a heterodimerisation "hinge" domain at one end and an <a href="/wiki/ATP-binding_cassette_transporter" class="mw-redirect" title="ATP-binding cassette transporter">ABC-type ATPase</a> "head" at the other. These globular domains are separated by a ~50 nm anti-parallel coiled-coil. SMC3 and SMC1 bind via their hinge domains creating V-shaped heterodimers. The N-terminal domain of RAD21 binds to the coiled coil of SMC3 just above the head domain while the C-terminal domain of RAD21 binds the head domain of SMC1. This end to end binding of the SMC3-SMC1-RAD21 trimer creates a closed ring within which DNA can be entrapped. SA1 or </p><p>When DNA is replicated and sister chromatid cohesion is established SMC3 is acetylated on a pair of highly conserved lysines by <a href="/wiki/ESCO1" title="ESCO1">ESCO1</a> and <a href="/wiki/ESCO2" title="ESCO2">ESCO2</a>. In budding yeast this modification is sufficient to stabilise cohesin on the DNA until mitosis but in animals, binding of sororin is also required. </p><p>During <a href="/wiki/Meiosis" title="Meiosis">meiosis</a>, SMC3 forms cohesin complexes with <a href="/wiki/SMC1B" title="SMC1B">SMC1ß</a>, <a href="/wiki/STAG3_(gene)" title="STAG3 (gene)">STAG3</a> and <a href="/wiki/REC8" title="REC8">REC8</a> which generate cohesion between homologous chromosomes and sister chromatids.<sup id="cite_ref-pmid20634189_6-0" class="reference"><a href="#cite_note-pmid20634189-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Cornelia_de_Lange_syndrome">Cornelia de Lange syndrome</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SMC3&action=edit&section=2" title="Edit section: Cornelia de Lange syndrome"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Cornelia_de_Lange_syndrome" title="Cornelia de Lange syndrome">Cornelia de Lange syndrome (CdLS)</a> is a rare genetic disorder that presents with variable clinical abnormalities including <a href="/wiki/Dysmorphic_feature" title="Dysmorphic feature">dysmorphic features</a>, severe growth retardation, <a href="/wiki/Global_developmental_delay" title="Global developmental delay">global developmental delay</a>, and <a href="/wiki/Intellectual_disability" title="Intellectual disability">intellectual disability</a>. SMC3 is one of five genes that have been implicated in CdLS.<sup id="cite_ref-pmid28781842_7-0" class="reference"><a href="#cite_note-pmid28781842-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> In one case report, a novel SMC3 gene duplication was detected in a child with <a href="/wiki/Failure_to_thrive" title="Failure to thrive">failure to thrive</a>, <a href="/wiki/Hypotonia" title="Hypotonia">hypotonia</a> and facial <a href="/wiki/Dysmorphic_feature" title="Dysmorphic feature">dysmorphic features</a> of CdLS.<sup id="cite_ref-pmid28781842_7-1" class="reference"><a href="#cite_note-pmid28781842-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> The same duplication was also observed in the mother, who had milder dysmorphic facies. </p> <div class="mw-heading mw-heading2"><h2 id="Role_in_Basement_Membrane">Role in Basement Membrane</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SMC3&action=edit&section=3" title="Edit section: Role in Basement Membrane"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SMC3 occurs in certain cell types as a secreted protein and post-translational addition of <a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">chondroitin sulfate</a> chains gives rise to the secreted <a href="/wiki/Proteoglycan" title="Proteoglycan">proteoglycan</a> <b>bamacan</b>, an abundant <a href="/wiki/Basement_membrane" title="Basement membrane">basement membrane</a> protein.<sup id="cite_ref-entrez_5-1" class="reference"><a href="#cite_note-entrez-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SMC3&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000108055">GRCh38: Ensembl release 89: ENSG00000108055</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000024974">GRCm38: Ensembl release 89: ENSMUSG00000024974</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=9126">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D9126&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASMC3" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=13006">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D13006&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASMC3" class="Z3988"></span></span> </li> <li id="cite_note-entrez-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-entrez_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-entrez_5-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9126">"Entrez Gene: SMC3 structural maintenance of chromosomes 3"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+SMC3+structural+maintenance+of+chromosomes+3&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3FDb%3Dgene%26Cmd%3DShowDetailView%26TermToSearch%3D9126&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASMC3" class="Z3988"></span></span> </li> <li id="cite_note-pmid20634189-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid20634189_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGarcia-CruzBrieñoRoigGrossmann2010" class="citation journal cs1">Garcia-Cruz R, Brieño MA, Roig I, Grossmann M, Velilla E, Pujol A, Cabero L, Pessarrodona A, Barbero JL, Garcia Caldés M (2010). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhumrep%2Fdeq180">"Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes"</a>. <i>Hum. Reprod</i>. <b>25</b> (9): 2316–27. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhumrep%2Fdeq180">10.1093/humrep/deq180</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20634189">20634189</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Hum.+Reprod.&rft.atitle=Dynamics+of+cohesin+proteins+REC8%2C+STAG3%2C+SMC1+beta+and+SMC3+are+consistent+with+a+role+in+sister+chromatid+cohesion+during+meiosis+in+human+oocytes&rft.volume=25&rft.issue=9&rft.pages=2316-27&rft.date=2010&rft_id=info%3Adoi%2F10.1093%2Fhumrep%2Fdeq180&rft_id=info%3Apmid%2F20634189&rft.aulast=Garcia-Cruz&rft.aufirst=R&rft.au=Brie%C3%B1o%2C+MA&rft.au=Roig%2C+I&rft.au=Grossmann%2C+M&rft.au=Velilla%2C+E&rft.au=Pujol%2C+A&rft.au=Cabero%2C+L&rft.au=Pessarrodona%2C+A&rft.au=Barbero%2C+JL&rft.au=Garcia+Cald%C3%A9s%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.1093%252Fhumrep%252Fdeq180&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASMC3" class="Z3988"></span></span> </li> <li id="cite_note-pmid28781842-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid28781842_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid28781842_7-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFInfanteAlkorta-AranburuEl-Gharbawy2017" class="citation journal cs1">Infante E, Alkorta-Aranburu G, El-Gharbawy A (2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538066">"Rare form of autosomal dominant familial Cornelia de Lange syndrome due to a novel duplication in SMC3"</a>. <i>Clinical Case Reports</i>. <b>5</b> (8): 1277–1283. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fccr3.1010">10.1002/ccr3.1010</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538066">5538066</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28781842">28781842</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Clinical+Case+Reports&rft.atitle=Rare+form+of+autosomal+dominant+familial+Cornelia+de+Lange+syndrome+due+to+a+novel+duplication+in+SMC3&rft.volume=5&rft.issue=8&rft.pages=1277-1283&rft.date=2017&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5538066%23id-name%3DPMC&rft_id=info%3Apmid%2F28781842&rft_id=info%3Adoi%2F10.1002%2Fccr3.1010&rft.aulast=Infante&rft.aufirst=E&rft.au=Alkorta-Aranburu%2C+G&rft.au=El-Gharbawy%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5538066&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASMC3" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SMC3&action=edit&section=5" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=cdls">GeneReviews/NCBI/UW/NIH entry on Cornelia de Lange syndrome</a></li> <li><a href="/wiki/ENCODE#FactorBook" title="ENCODE">FactorBook</a> <a rel="nofollow" class="external text" href="http://www.factorbook.org/mediawiki/index.php/SMC3">SMC3</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist 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navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Glycoproteins" title="Template:Glycoproteins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Glycoproteins" title="Template talk:Glycoproteins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Glycoproteins" title="Special:EditPage/Template:Glycoproteins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Protein,_glycoconjugate:_glycoproteins_and_glycopeptides" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Protein</a>, <a href="/wiki/Glycoconjugate" title="Glycoconjugate">glycoconjugate</a>: <a href="/wiki/Glycoprotein" title="Glycoprotein">glycoproteins</a> and <a href="/wiki/Glycopeptide" title="Glycopeptide">glycopeptides</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Mucoprotein" title="Mucoprotein">Mucoproteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Mucin" title="Mucin">Mucin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/CD164" title="CD164">CD164</a></li> <li><a href="/wiki/MUC1" class="mw-redirect" title="MUC1">MUC1</a></li> <li><a href="/wiki/MUC2" class="mw-redirect" title="MUC2">MUC2</a></li> <li><a href="/wiki/MUC3A" class="mw-redirect" title="MUC3A">MUC3A</a></li> <li><a href="/wiki/MUC3B" class="mw-redirect" title="MUC3B">MUC3B</a></li> <li><a href="/wiki/MUC4" class="mw-redirect" title="MUC4">MUC4</a></li> <li><a href="/wiki/MUC5AC" class="mw-redirect" title="MUC5AC">MUC5AC</a></li> <li><a href="/wiki/MUC5B" class="mw-redirect" title="MUC5B">MUC5B</a></li> <li><a href="/wiki/MUC6" class="mw-redirect" title="MUC6">MUC6</a></li> <li><a href="/wiki/MUC7" class="mw-redirect" title="MUC7">MUC7</a></li> <li><a href="/wiki/MUC8" class="mw-redirect" title="MUC8">MUC8</a></li> <li><a href="/wiki/Mucin" title="Mucin">MUC12</a></li> <li><a href="/wiki/MUC13" class="mw-redirect" title="MUC13">MUC13</a></li> <li><a href="/wiki/MUC15" class="mw-redirect" title="MUC15">MUC15</a></li> <li><a href="/wiki/CA-125" class="mw-redirect" title="CA-125">MUC16</a></li> <li><a href="/wiki/MUC17" class="mw-redirect" title="MUC17">MUC17</a></li> <li><a href="/wiki/MUC19" class="mw-redirect" title="MUC19">MUC19</a></li> <li><a href="/wiki/MUC20" class="mw-redirect" title="MUC20">MUC20</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Haptoglobin" title="Haptoglobin">Haptoglobin</a></li> <li><a href="/wiki/Intrinsic_factor" title="Intrinsic factor">Intrinsic factor</a></li> <li><a href="/wiki/Orosomucoid" title="Orosomucoid">Orosomucoid</a></li> <li><a href="/wiki/Peptidoglycan" title="Peptidoglycan">Peptidoglycan</a></li> <li><a href="/wiki/Phytohaemagglutinin" title="Phytohaemagglutinin">Phytohaemagglutinin</a></li> <li><a href="/wiki/Ovomucin" title="Ovomucin">Ovomucin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Proteoglycan" title="Proteoglycan">Proteoglycans</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a>/<a href="/wiki/Dermatan_sulfate" title="Dermatan sulfate">DS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Decorin" title="Decorin">Decorin</a></li> <li><a href="/wiki/Biglycan" title="Biglycan">Biglycan</a></li> <li><a href="/wiki/Versican" title="Versican">Versican</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Heparan_sulfate" title="Heparan sulfate">HS</a>/<a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Testican" title="Testican">Testican</a></li> <li><a href="/wiki/Perlecan" title="Perlecan">Perlecan</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chondroitin_sulfate_proteoglycan" title="Chondroitin sulfate proteoglycan">Chondroitin sulfate proteoglycans</a>: <a href="/wiki/Aggrecan" title="Aggrecan">Aggrecan</a></li> <li><a href="/wiki/Neurocan" title="Neurocan">Neurocan</a></li> <li><a href="/wiki/Brevican" title="Brevican">Brevican</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/CSPG4" title="CSPG4">CSPG4</a></li> <li><a href="/wiki/CSPG5" title="CSPG5">CSPG5</a></li> <li><a href="/wiki/Platelet_factor_4" title="Platelet factor 4">Platelet factor 4</a></li> <li><a href="/wiki/SMC3_(gene)" class="mw-redirect" title="SMC3 (gene)">Structural maintenance of chromosomes 3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Keratan_sulfate" title="Keratan sulfate">KS</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fibromodulin" title="Fibromodulin">Fibromodulin</a></li> <li><a href="/wiki/Lumican" title="Lumican">Lumican</a></li> <li><a href="/wiki/Keratocan" title="Keratocan">Keratocan</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Heparan_sulfate" title="Heparan sulfate">HS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Syndecan_1" title="Syndecan 1">Syndecan 1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activin_and_inhibin" title="Activin and inhibin">Activin and inhibin</a></li> <li><a href="/wiki/A_disintegrin_and_metalloproteinase" class="mw-redirect" title="A disintegrin and metalloproteinase">ADAM</a></li> <li><a href="/wiki/Alpha_1-antichymotrypsin" title="Alpha 1-antichymotrypsin">Alpha 1-antichymotrypsin</a></li> <li><a href="/wiki/Apolipoprotein_H" title="Apolipoprotein H">Apolipoprotein H</a></li> <li><a href="/wiki/CD70" title="CD70">CD70</a></li> <li><a href="/wiki/Asialoglycoprotein" title="Asialoglycoprotein">Asialoglycoprotein</a></li> <li><a href="/wiki/Avidin" title="Avidin">Avidin</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">B-cell activating factor</a></li> <li><a href="/wiki/4-1BB_ligand" class="mw-redirect" title="4-1BB ligand">4-1BB ligand</a></li> <li><a href="/wiki/Cholesterylester_transfer_protein" class="mw-redirect" title="Cholesterylester transfer protein">Cholesterylester transfer protein</a></li> <li><a href="/wiki/Clusterin" title="Clusterin">Clusterin</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factor</a></li> <li><a href="/wiki/Hemopexin" title="Hemopexin">Hemopexin</a></li> <li><a href="/wiki/Lactoferrin" title="Lactoferrin">Lactoferrin</a></li> <li><a href="/wiki/Membrane_glycoproteins" title="Membrane glycoproteins">Membrane glycoproteins</a></li> <li><a href="/wiki/Myelin_protein_zero" title="Myelin protein zero">Myelin protein zero</a></li> <li><a href="/wiki/Osteonectin" title="Osteonectin">Osteonectin</a></li> <li><a href="/wiki/Protein_C" title="Protein C">Protein C</a></li> <li><a href="/wiki/Protein_S" title="Protein S">Protein S</a></li> <li><a href="/wiki/Serum_amyloid_P_component" title="Serum amyloid P component">Serum amyloid P component</a></li> <li><a href="/wiki/Sialoglycoprotein" title="Sialoglycoprotein">Sialoglycoprotein</a> <ul><li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/Glycophorin" title="Glycophorin">Glycophorin</a></li> <li><a href="/wiki/Glycophorin_C" title="Glycophorin C">Glycophorin C</a></li></ul></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin</a></li> <li><a href="/wiki/Thyroglobulin" title="Thyroglobulin">Thyroglobulin</a></li> <li><a href="/wiki/Thyroxine-binding_proteins" title="Thyroxine-binding proteins">Thyroxine-binding proteins</a></li> <li><a href="/wiki/Transcortin" title="Transcortin">Transcortin</a></li> <li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">Tumor necrosis factor alpha</a></li> <li><a href="/wiki/Uteroglobin" title="Uteroglobin">Uteroglobin</a></li> <li><a href="/wiki/Vitronectin" title="Vitronectin">Vitronectin</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Structures_of_the_cell_nucleus_/_nuclear_protein" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Nucleus" title="Template:Nucleus"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Nucleus" title="Template talk:Nucleus"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Nucleus" title="Special:EditPage/Template:Nucleus"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Structures_of_the_cell_nucleus_/_nuclear_protein" style="font-size:114%;margin:0 4em">Structures of the <a href="/wiki/Cell_nucleus" title="Cell nucleus">cell nucleus</a> / <a href="/wiki/Nuclear_protein" title="Nuclear protein">nuclear protein</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nuclear_envelope" title="Nuclear envelope">Envelope (membrane)</a>/<br /><a href="/wiki/Nuclear_lamina" title="Nuclear lamina">nuclear lamina</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclear_pore" title="Nuclear pore">Pore complex</a>:</li> <li><a href="/wiki/Nucleoporin" title="Nucleoporin">Nucleoporin</a> <ul><li><a href="/wiki/NUP35" class="mw-redirect" title="NUP35">NUP35</a></li> <li><a href="/wiki/NUP37" class="mw-redirect" title="NUP37">NUP37</a></li> <li><a href="/wiki/NUP43" class="mw-redirect" title="NUP43">NUP43</a></li> <li><a href="/wiki/NUP50" class="mw-redirect" title="NUP50">NUP50</a></li> <li><a href="/wiki/NUP54" class="mw-redirect" title="NUP54">NUP54</a></li> <li><a href="/wiki/Nucleoporin_62" class="mw-redirect" title="Nucleoporin 62">NUP62</a></li> <li><a href="/wiki/NUP85" class="mw-redirect" title="NUP85">NUP85</a></li> <li><a href="/wiki/NUP88" class="mw-redirect" title="NUP88">NUP88</a></li> <li><a href="/wiki/NUP93" class="mw-redirect" title="NUP93">NUP93</a></li> <li><a href="/wiki/NUP98" title="NUP98">NUP98</a></li> <li><a href="/wiki/NUP107" class="mw-redirect" title="NUP107">NUP107</a></li> <li><a href="/wiki/NUP133" class="mw-redirect" title="NUP133">NUP133</a></li> <li><a href="/wiki/NUP153" class="mw-redirect" title="NUP153">NUP153</a></li> <li><a href="/wiki/NUP155" class="mw-redirect" title="NUP155">NUP155</a></li> <li><a href="/wiki/NUP160" class="mw-redirect" title="NUP160">NUP160</a></li> <li><a href="/wiki/NUP188" class="mw-redirect" title="NUP188">NUP188</a></li> <li><a href="/wiki/NUP205" class="mw-redirect" title="NUP205">NUP205</a></li> <li><a href="/wiki/Nucleoporin_210kDa" title="Nucleoporin 210kDa">NUP210</a></li> <li><a href="/wiki/NUP214" class="mw-redirect" title="NUP214">NUP214</a></li></ul></li> <li><a href="/wiki/AAAS_(gene)" class="mw-redirect" title="AAAS (gene)">AAAS</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nucleolus" title="Nucleolus">Nucleolus</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cajal_body" title="Cajal body">Cajal (coiled) body</a> <ul><li><a href="/wiki/Survival_of_motor_neuron" title="Survival of motor neuron">SMN</a></li> <li><a href="/wiki/Gem-associated_protein_2" title="Gem-associated protein 2">GEMIN2</a></li> <li><a href="/wiki/Gem-associated_protein_4" title="Gem-associated protein 4">GEMIN4</a></li> <li><a href="/wiki/Gem-associated_protein_5" title="Gem-associated protein 5">GEMIN5</a></li> <li><a href="/wiki/Gem-associated_protein_6" title="Gem-associated protein 6">GEMIN6</a></li> <li><a href="/wiki/Gem-associated_protein_7" title="Gem-associated protein 7">GEMIN7</a></li> <li><a href="/wiki/DDX20" title="DDX20">DDX20</a></li> <li><a href="/wiki/Coilin" title="Coilin">COIL</a></li></ul></li> <li><a href="/wiki/Perinucleolar_compartment" title="Perinucleolar compartment">Perinucleolar compartment</a> <ul><li><a href="/wiki/PTBP1" title="PTBP1">PTBP1</a></li> <li><a href="/wiki/CUGBP1" title="CUGBP1">CUGBP1</a></li></ul></li> <li><a href="/wiki/Treacle_protein" title="Treacle protein">TCOF</a></li> <li><a href="/wiki/Ataxin_7" title="Ataxin 7">ATXN7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chromatin" title="Chromatin">Chromatin</a></li> <li><a href="/wiki/Nuclear_dots" class="mw-redirect" title="Nuclear dots">Dot (PML body)</a></li> <li><a href="/wiki/Paraspeckle" title="Paraspeckle">Paraspeckle</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/SMC_protein" title="SMC protein">SMC protein</a>:</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cohesin" title="Cohesin">Cohesin</a> <ul><li><a href="/wiki/SMC1A" title="SMC1A">SMC1A</a></li> <li><a href="/wiki/SMC1B" title="SMC1B">SMC1B</a></li> <li><a class="mw-selflink selflink">SMC3</a></li></ul></li> <li><a href="/wiki/Condensin" title="Condensin">Condensin</a> <ul><li><a href="/wiki/NCAPD2" title="NCAPD2">NCAPD2</a></li> <li><a href="/wiki/NCAPD3" title="NCAPD3">NCAPD3</a></li> <li><a href="/wiki/NCAPG" title="NCAPG">NCAPG</a></li> <li><a href="/wiki/NCAPG2" title="NCAPG2">NCAPG2</a></li> <li><a href="/wiki/NCAPH" title="NCAPH">NCAPH</a></li> <li><a href="/wiki/NCAPH2" title="NCAPH2">NCAPH2</a></li> <li><a href="/wiki/SMC2" title="SMC2">SMC2</a></li> <li><a href="/wiki/SMC4" title="SMC4">SMC4</a></li></ul></li> <li><a href="/wiki/DNA_repair" title="DNA repair">DNA repair</a> <ul><li><a href="/wiki/SMC5" title="SMC5">SMC5</a></li> <li><a href="/wiki/SMC6" title="SMC6">SMC6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Transition_nuclear_protein" title="Transition nuclear protein">Transition nuclear protein</a>:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><ul><li><a href="/wiki/TNP1" title="TNP1">TNP1</a></li> <li><a href="/wiki/TNP2" title="TNP2">TNP2</a></li></ul></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclear_matrix" title="Nuclear matrix">Nuclear matrix</a> (Nucleoskeleton)</li> <li><a href="/wiki/Nucleoplasm" title="Nucleoplasm">Nucleoplasm</a> (Nucleosol)</li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/LITAF" title="LITAF">LITAF</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>see also <a href="/wiki/Template:Transcription_factors_and_intracellular_receptors" title="Template:Transcription factors and intracellular receptors">transcription factors and intracellular receptors</a></i></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="padding:0;"><div><i>see also <a href="/wiki/Template:Nucleus_diseases" title="Template:Nucleus diseases">nucleus diseases</a></i></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1&useformat=desktop" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=SMC3&oldid=1190497786">https://en.wikipedia.org/w/index.php?title=SMC3&oldid=1190497786</a>"</div></div> <div 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