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Tang Lab | Diabetes Center at UCSF
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class="lab-nav__wrap"> <div class="lab-nav__title">Tang Lab</div> <div class="lab-nav__menu"> <div class="item-list"><ul><li><a href="https://diabetes.ucsf.edu/lab/tang-lab/members">Members</a></li><li><a href="https://diabetes.ucsf.edu/lab/tang-lab/publications">Publications</a></li><li><a href="https://diabetes.ucsf.edu/lab/tang-lab/news">News</a></li></ul></div> </div> </div> </span></div></div> </div> </div> </div> </div> <div id="block-diabetes-content" data-block-plugin-id="system_main_block" class="block block-system block-system-main-block"> <div class="group group--full group--labs"> <div> <div class="component field-components component--type-entity-reference-revisions component--label-hidden component__items"> <div class="component__item"> <div class="cta-alt paragraph paragraph--type--cta paragraph--view-mode--default"> <div class="cta-alt__wrap"> <div class="cta-alt__wrap-inner"> <div class="cta-alt__media"> <div class="cta-alt__feature-image"> <article class="media 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</div> </div> </article> </div> </div> <div class="cta-alt__content"> <div class="cta-alt__text"> <p class="overline">Tang Lab</p> <h3 class="component-title"> <span>Immune tolerance and novel therapeutics for Type 1 Diabetes</span></h3> <div class="paragraph paragraph--type--text-box paragraph--view-mode--text-box-only"> <div class="clearfix text-formatted field field-wysiwyg field--type-text-long field--label-hidden field__item"><p>Therapeutic application of regulatory T cell therapy and immune suppression-free transplantation of stem-cell-derived beta cells for treatment of type 1 diabetes</p></div> </div> </div> </div> </div> </div> </div> </div> <div class="component__item"> <div class="paragraph paragraph--type--text-box paragraph--view-mode--default"> <div class="text-content"> <p class="overline">Research</p> <div class="clearfix text-formatted field field-wysiwyg field--type-text-long field--label-hidden field__item"><p>Regulatory T cells are a small population of white blood cells that are essential for preventing tissue damages caused by over activation of the immune system. The Tang lab has shown that infusion of regulatory T cells in animal models can reverse type 1 diabetes, a disease caused by immune destruction of insulin-producing cells in the pancreatic islets. Similarly, regulatory T cell therapy can prevent rejection of transplanted organs in animal models. A joint team of researchers from the Tang and Bluestone labs is currently conducting 6 clinical trials evaluating the safety and efficacy of regulatory T cell therapy in patients. In the mean time, we are developing next generation regulatory T cell therapies in preclinical models to improve the safety and efficacy of the therapy.</p> <p>In patients with chronic type 1 diabetes, transplanting of stem-cell-derived beta cells can potentially cure the disease, but patients have to commit to life-long immunosuppression to prevent rejection of the transplanted cells from rejection by the immune system. The Tang lab is currently investigating approaches to shield the transplanted cells from the immune systems using novel biomaterials developed in the Desai and Roy labs at UCSF. We are also applying genome-editing technologies to immunoengineer stem cells to evade immune rejection.</p></div> </div> </div> </div> </div> </div> </div> </div> </main> <footer role="footer" class="footer"> <div class="footer__container"> <div class="footer__wrap"> <div class="footer__inner"> <div class="footer__first"> <figure class="footer__logo"> <a class="footer__logo-link" href="/"> <picture class="footer__logo-image"> <img class="footer-logo__img" src="/sites/diabetes.ucsf.edu/themes/custom/diabetes/images/footer-logo.png" alt="UCSF Diabetes Footer Logo"> </picture> </a> </figure> <p> 漏 2024 The University of California San Francisco | UCSF Diabetes Center </p> </div> <div class="footer__second"> <div class="region-footer"> <div id="block-footer-cta" class="footer-cta-btn block block-block-content block-block-content761a1ff4-b383-447f-8721-ffb6d63563dd" data-block-plugin-id="block_content:761a1ff4-b383-447f-8721-ffb6d63563dd"> <div class="clearfix text-formatted field body 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