CINXE.COM

<!DOCTYPE html> <html> <head><link rel="stylesheet" type="text/css" href="/DXR.axd?r=0_2312,1_50,1_53,1_51,0_2317-HCSds&p=3566a23a" /><link rel="stylesheet" type="text/css" href="/DXR.axd?r=0_2214,1_16,0_2219,1_17-HCSds&p=3566a23a" /><meta charset="utf-8" /><meta name="viewport" content="width=device-width, initial-scale=0.3" /><link rel="shortcut icon" href="/favicon.ico" /><title> Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar </title><script src="/bundles/jquery?v=uFgEwkmfdwWoDMz6vEeIoql0PDF7uHxE-GEoIW9UY9M1"></script> <script src="/bundles/json2?v=d1Efh1-9UFdw-Pnj4VVUxViXmZK9H1kqbY_kx2U79DM1"></script> <script src="/bundles/site?v=Uby6LDuaSQ1_He97UGZvnGv_wln5mTgGNE3q1RwRMEQ1"></script> <link href="/Style/css?v=moasmn2BWK6Px64tnr4mMXZfX9KqyGOs6yBj9kZctxQ1" rel="stylesheet"/> <script src="/bundles/search?v=oKWBTbQ1Eyu3c78HTcS6WrXwgMWPpz68IXv5mSC3oqQ1"></script>  <script async src="https://www.googletagmanager.com/gtag/js?id=UA-221132522-1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag() { dataLayer.push(arguments); } gtag('js', new Date()); gtag('config', 'UA-221132522-1'); </script> <script type="text/javascript"> $(function () { InitCategoryIcon(); AddArticleSearchRecord(); }); </script> <meta name="application-name" content="ReferenceCitationAnalysis" /> <meta name="msapplication-TileColor" content="#bd4100" /> <meta name="description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> <meta property="og:site" content="ReferenceCitationAnalysis" /> <meta property="og:site_name" content="ReferenceCitationAnalysis" /> <meta property="og:type" content="website" /> <meta property="og:url" content="https://referencecitationanalysis.com/" /> <meta property="og:title" content="Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar" /> <meta property="og:description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> <meta name="twitter:title" content="Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://referencecitationanalysis.com/" /> <meta name="twitter:description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> </head> <body> <form method="post" action="./search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" id="form1"> <div class="aspNetHidden"> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" value="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" /> </div> <script type="text/javascript"> //<![CDATA[ var theForm = document.forms['form1']; if (!theForm) { theForm = document.form1; } function __doPostBack(eventTarget, eventArgument) { if (!theForm.onsubmit || (theForm.onsubmit() != false)) { theForm.__EVENTTARGET.value = eventTarget; theForm.__EVENTARGUMENT.value = eventArgument; theForm.submit(); } } //]]> </script> <script src="/WebResource.axd?d=pynGkmcFUV13He1Qd6_TZDkCPVD1CEgIJIwX-djYyD12MdD7MbGguneDtbgL0T4_DTGNirF3uaaW3m5irAIXOA2&t=638628207619783110" type="text/javascript"></script> <script id="dxis_725862373" src="/DXR.axd?r=1_304-HCSds" type="text/javascript"></script><script id="dxis_117419880" src="/DXR.axd?r=1_185-HCSds" type="text/javascript"></script><script id="dxis_2117664241" src="/DXR.axd?r=1_188-HCSds" type="text/javascript"></script> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATEGENERATOR" id="__VIEWSTATEGENERATOR" value="54D499A9" /> <input type="hidden" name="__EVENTVALIDATION" id="__EVENTVALIDATION" value="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" /> </div> <input type="hidden"/><script id="dxis_1899801520" src="/DXR.axd?r=1_298,1_211,1_221,1_182,1_277,1_198,1_209,1_217,1_190,1_223,1_208,1_290,1_206,1_288,1_212,1_286,1_296,1_299,1_224,1_201,1_216-HCSds" type="text/javascript"></script><table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="ASPxLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="width:0px;vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="ASPxLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="ASPxLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1948350305" type="text/javascript">  </script> <div class="top-part cl"> <div class="top-content" id="top"> <ul class="ul"> <li class="logo fl"> <a href="https://www.wjgnet.com" target="_blank"> <img src="/Contents/Images/Bpg-logo-new.svg" /> </a> </li> <li class="rca-title fl"> <a href="/" class="clearlink"> <img src="../Contents/Images/RCA-Logo.svg" alt="Reference Citation Analysis" /> </a> </li> <li id="PageTopControl_loginContainer" class="logined fr"> <table> <tr> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_Login" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_Login_I" class="dxb-hb" value="Login" type="submit" name="ctl00$PageTopControl$Login" /><span class="dx-vam">Login</span> </div> </div><script id="dxss_309739120" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_AuthorRegist" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_AuthorRegist_I" class="dxb-hb" value="Scholar Register" type="submit" name="ctl00$PageTopControl$AuthorRegist" /><span class="dx-vam">Scholar Register</span> </div> </div><script id="dxss_216236472" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_BusinessRegist" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_BusinessRegist_I" class="dxb-hb" value="Business Register" type="submit" name="ctl00$PageTopControl$BusinessRegist" /><span class="dx-vam">Business Register</span> </div> </div><script id="dxss_1760396766" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_Subscribe" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_Subscribe_I" class="dxb-hb" value="Subscribe" type="submit" name="ctl00$PageTopControl$Subscribe" /><span class="dx-vam">Subscribe</span> </div> </div><script id="dxss_1089838522" type="text/javascript">  </script> </td> </tr> </table> </li> </ul> </div> </div> <div class="main-part cl"> <div class="main-search-container"> <div class="search-form search-centered"> <div class="search-component-container"> <ul class="ul cl"> <li class="fl"> <table id="FieldItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="FieldItems_TL">Loading…</span></td> </tr> </table><div id="FieldItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox FieldItems" id="FieldItems"> <tr> <td style="display:none;"><input id="FieldItems_VI" name="FieldItems_VI" type="hidden" value="mesh" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="FieldItems_I" name="ctl00$FieldItems" onfocus="ASPx.EGotFocus('FieldItems')" onblur="ASPx.ELostFocus('FieldItems')" onchange="ASPx.ETextChanged('FieldItems')" value="MESH Heading" type="text" /></td><td id="FieldItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="FieldItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="FieldItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="FieldItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="FieldItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="FieldItems_DDD_L_VI" type="hidden" name="ctl00$FieldItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="FieldItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="FieldItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="FieldItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Article Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Abstract</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Keyword</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Category</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">MESH Heading</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Grant Agency</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">RCAID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">DOI</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMCID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Author</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Affiliation</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Email</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Journal Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">ISSN</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Publisher</td> </tr> </table> </div></td> </tr> </table><script id="dxss_153608340" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1280586772" type="text/javascript">  </script><script id="dxss_14646264" type="text/javascript">  </script> </li> <li class="fl"> <table id="OpeartorItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="OpeartorItems_TL">Loading…</span></td> </tr> </table><div id="OpeartorItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox OpeartorItems" id="OpeartorItems"> <tr> <td style="display:none;"><input id="OpeartorItems_VI" name="OpeartorItems_VI" type="hidden" value="Equals" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="OpeartorItems_I" name="ctl00$OpeartorItems" onfocus="ASPx.EGotFocus('OpeartorItems')" onblur="ASPx.ELostFocus('OpeartorItems')" onchange="ASPx.ETextChanged('OpeartorItems')" value="Equals" type="text" /></td><td id="OpeartorItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="OpeartorItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="OpeartorItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="OpeartorItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="OpeartorItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="OpeartorItems_DDD_L_VI" type="hidden" name="ctl00$OpeartorItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="OpeartorItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="OpeartorItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="OpeartorItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Contains</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Equals</td> </tr> </table> </div></td> </tr> </table><script id="dxss_597138281" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_24426426" type="text/javascript">  </script><script id="dxss_1793334323" type="text/javascript">  </script> </li> <li id="TermInputContainer" class="fl TermInputContainer"> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue input-text SearchTermText dxeTextBoxDefaultWidthSys" id="SearchTerm"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="SearchTerm_I" name="ctl00$SearchTerm" onfocus="ASPx.EGotFocus('SearchTerm')" onblur="ASPx.ELostFocus('SearchTerm')" onchange="ASPx.EValueChanged('SearchTerm')" value="Fatty Liver/pathology" type="text" /></td> </tr> </table><script id="dxss_543298418" type="text/javascript">  </script> <span class="search-icon-container"> <a class="search-icon" href="javascript:openCategorySelector(1);"><img src="/Contents/Images/search.png" /></a> </span> </li> <li class="fl"> <div class="dxbButton_MetropolisBlue SearchButton dxbButtonSys dxbTSys" id="SearchArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="SearchArticle_I" class="dxb-hb" value="Find an Article" type="submit" name="ctl00$SearchArticle" /><span class="dx-vam">Find an Article</span> </div> </div><script id="dxss_842240986" type="text/javascript">  </script> </li> </ul> <div class="cl"></div> <div class="search-menu"> <span>Find an Article (55810868)</span>   <a href="/Categories" target="_blank">Find a Category (125)</a>   <a href="/SearchJournal" target="_blank">Find a Journal (6160)</a>   <a href="/searchscholar" target="_blank">Find a Scholar (3725)</a>   <a href="/searchacademicassistant" target="_blank">Find an Academic Assistant (18)</a> </div> <div class="search-menu" style="text-align:center;"> <span>Find an Article PDF (4648835)</span>   <a href="/TodayArticles" target="_self">Today's Articles (4003)</a>   <span>Subscriber (50769)</span> </div> </div> </div> </div> <script src="/bundles/UserAcademicAchievement?v=QYKvd9c2mOpOgKt90go7osO6NdxcNzivChzWAq_gw3g1"></script> <script type="text/javascript"> $(function () { try { var sort = getQueryString2('sort'); if (sort != null && sort != '') { if ($("[field='st" + sort + "']").length) { $("[field='st" + sort + "']").addClass("sort-highlight"); } if ($("#" + sort + "sortedCheck").length) { $("#" + sort + "sortedCheck").prop("checked", true); } } $("a.readmore").click(function () { $(this).parent().toggle().next().toggle(); }); $("a.readless").click(function () { $(this).parent().toggle().prev().toggle(); }); var action = getQueryString2('action'); if (action != null && action != '') { if ($("a[name='" + action + "']").length) { $("a[name='" + action + "']").first().click(); } } InitializeResultAnalysisBtn(); } catch (e) { } try { $(".file-container-btn").each(function () { var itemCount = parseInt($(this).attr("item-count")); if (itemCount > 0) { $(this).click(function () { var controlId = $(this).attr("aria-controls"); $("#" + controlId).toggle(); var fa = $(this).children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } }); } }); InitAchievementContents(true); InitYearFacets(); setTimeout(() => setUserContainerBorder(), 1000); setTimeout(() => setUserContainerBorder(), 2000); setTimeout(() => setUserContainerBorder(), 5000); } catch (e) { } AddVisitRecord(2); }); function DeleteArticle(doi) { if (confirm("Confirm Delete the Artilce?")) { LoadingPanel.Show(); try { if (doi != '') { var uri = "/api/BpgUser/DeleteArticle?doi=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, async: false, success: function () { window.location.href = window.location.href; } }); } } catch (e) { } finally { LoadingPanel.Hide(); } } } function Refresh() { CloseEdit(); window.location.href = window.location.href; } function CloseEdit() { pcEditArticleControl.Hide(); } function EditArticle(doi) { pcEditArticleControl.SetContentUrl("/EditUserArticle?Id=" + encodeURIComponent(doi)); pcEditArticleControl.Show(); } function setUserContainerBorder() { try { var leftContainerHeight = $('.user-info-center-container .left-part').outerHeight(); var rightContainerHeight = $('.user-info-center-container .right-part').outerHeight(); if (leftContainerHeight > rightContainerHeight) { $('.user-info-center-container .left-part').css('border-right', '1px solid #C0C0C0'); $('.user-info-center-container .right-part').css('border-left', ''); } else { $('.user-info-center-container .right-part').css('border-left', '1px solid #C0C0C0'); $('.user-info-center-container .left-part').css('border-right', ''); } } catch (e) { } } function ShowUserFriendList() { var expandContainer = $(".expandUserFriend"); $(".user-friend-list").toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function ShowUserContainerList(className, listClassName) { var expandContainer = $("." + className); $("." + listClassName).toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function OpenMessage(id, friendId) { OpenFriendMessage(friendId); $("div[name='countcontainer" + id + "']").hide(); } function DeleteFriend(id) { if (confirm("Confirm Delete the Friend?")) { LoadingPanel.Show(); var uri = "/api/BpgUser/DeleteFriend?id=" + id; $.ajax({ type: "get", url: uri, async: false }).done(function () { window.location.href = window.location.href; }); } } function SelectAllFriend() { $("input[name='checkfriend']").each(function () { $(this).attr("checked", $('#selectAllFriend').prop("checked")); }); onCheckFriendClick(); } function onCheckFriendClick() { var itemArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); }); if (itemArray.length > 0) { $("#BatchMessageContainer").show(); } else { $("#BatchMessageContainer").hide(); } } function SendBatchMessages() { var itemArray = new Array(); var idArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); idArray.push($(this).attr("data-id")); }); if (itemArray.length > 0) { if (itemArray.length == 1) { OpenMessage(idArray[0], itemArray[0]); } else { var friendIds = JSON.stringify(itemArray); OpenBatchFriendMessage(friendIds); } } } function ImportSingleArticle(doi, controlId) { if (doi != '') { LoadingPanel.Show(); var uri = "/api/BpgUser/ImportArticle?doiPmid=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function (data) { LoadingPanel.Hide(); if (data) { alert("Import Successfully!"); var currentControl = $("#" + controlId); currentControl.parent().hide(); } }).always(function () { LoadingPanel.Hide(); }); } } function ImportAllArticles() { LoadingPanel.Show(); var term = getQueryString2('term'); var uri = "/api/BpgUser/ImportArticlesFromSearch?term=" + term; $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function () { LoadingPanel.Hide(); alert("Imorting is executing!"); }).always(function () { LoadingPanel.Hide(); }); } </script> <input type="hidden" name="ctl00$RootHolder$RCAId" id="RCAId" /> <input type="hidden" name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">3753</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (358)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (1623)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Fatty Liver/pathology</label> </div> <div id="yearFacetContainer"> <div class="mnavbar"> <div> Year Published </div> </div> <div class="mnavbox"> <div id="yearFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('year');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refineyearcheck" target="_self">Refine</a> </div> </div> </div> <div id="jsFacetContainer"> <div class="mnavbar"> <div> Article Statistics </div> </div> <div class="mnavbox"> <div id="jsFacetItemContainer"> </div> <div class="refine-btn-container cl" name="refinejscheck"> <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejscheck" target="_self">Refine</a> </div> </div> </div> <div class="mnavbar"> <div> Ranked By </div> </div> <div class="mnavbox"> <ul class="ul sortedby-list"> <li> <input type="radio" id="aisortedCheck" onclick="SetSorted('ai')" name="sortedbycheck" value="aisorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('ai')" id="aisorted">Impact Index Per Article</a> </li> <li> <input type="radio" id="citedf6sortedCheck" onclick="SetSorted('citedf6')" name="sortedbycheck" value="citedf6sorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('citedf6')" id="citedf6sorted"> Citation(s) in <i>RCA</i> </a> </li> </ul> </div> <div id="RootHolder_ResultsAnalysisContainer"> <div class="mnavbar"> <div> Results Analysis </div> </div> <div class="mnavbox"> <ul class="ul analysis-list"> <li> <input type="checkbox" id="YearAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="year" />  <label for="YearAnalysis">Year Published Analysis</label> </li> <li> <input type="checkbox" id="ArticleTypeAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="at" />  <label for="ArticleTypeAnalysis">Article Type Analysis</label> </li> <li> <input type="checkbox" id="JournalTitleAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="journal" />  <label for="JournalTitleAnalysis">Publication Title Analysis</label> </li> <li> <input type="checkbox" id="CategoriesAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="subject" />  <label for="CategoriesAnalysis">Category Analysis</label> </li> </ul> <div class="refine-btn-container cl" name="analysis-check-btn-container"> <a href="javascript:ResultAnalysis();" class="refine-link-btn refine-link-btn-right" target="_self">Results Analysis</a> </div> </div> </div> <div class="refine-btn-container-n cl" id="showFacetsContainer"> <a href="javascript:InitAllFacets();" class="refine-link-btn-right" target="_self">Show more</a> </div> <div id="facetsContainer" class="cl" style="display: none;"> <div class="mnavbar" id="PubDateFacetTitle"> <div> Indexed Articles </div> </div> <div class="mnavbox" id="PubDateFacetContainer"> <ul class="ul sortedby-list"> <li> <a href="javascript:SubmitSingleFacetSearch('create','6');">Today (<span id="indexCount6"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','5');">Yesterday (<span id="indexCount5"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','4');">This Week (<span id="indexCount4"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','3');">Last Week (<span id="indexCount3"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','2');">Current Month (<span id="indexCount2"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','1');">Last Month (<span id="indexCount1"></span>)</a> </li> </ul> </div> <div id="journalFacetContainer"> <div class="mnavbar"> <div> Publication Titles </div> </div> <div class="mnavbox"> <div id="journalFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('journal');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejournalcheck" target="_self">Refine</a> </div> </div> </div> <div id="fundFacetContainer"> <div class="mnavbar"> <div> Grant Agencies </div> </div> <div class="mnavbox"> <div id="fundFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('fund');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinefundcheck" target="_self">Refine</a> </div> </div> </div> <div id="subjectFacetContainer"> <div class="mnavbar"> <div> Category </div> </div> <div class="mnavbox"> <div id="subjectFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('subject');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Siciliani D</b>, Ruyter B, Løkka G, Præsteng KE, Minghetti M, Kortner TM. A fish intestinal in vitro model for investigation of lipid metabolism and steatosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(168092);'>Biochim Biophys Acta Mol Cell Biol Lipids</em> 2025;<b>1870</b>:159573. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39490958' target='_blank'>39490958</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbalip.2024.159573' target='_blank'>10.1016/j.bbalip.2024.159573</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbalip.2024.159573','39490958', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbalip.2024.159573' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168092);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.bbalip.2024.159573" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Choline is now recognized as an essential nutrient to ensure lipid transport in Atlantic salmon. Its deficiency leads to excessive lipid accumulation in the enterocytes, a condition known as steatosis. The knowledge of lipid metabolism and steatosis in fish remains limited, motivating the use of in vitro intestinal models to perform deeper explorations. This study aimed to create an in vitro steatosis model using RTdi-MI, a new cell line derived from the distal intestine of rainbow trout. Cells were exposed to varying oleic acid (OA) concentrations over different time points (24 h, 72 h, and 168 h). Results indicated that the increasing OA concentration enhanced intracellular lipid droplet formation. Quantitative lipid analysis confirmed OA accumulation, which intensified with prolonged exposure and increased OA dose. Moreover, all cells, including controls, exhibited fatty acid metabolic activity. Such outcome was confirmed by light and fluorescence microscopy. Additionally, RTdi-MI cells expressed genes involved in lipid metabolism and synthesis similar to in vivo conditions. Collectively, our findings demonstrate the ability of RTdi-MI cells to accumulate OA in intracellular lipid droplets and mirror in vivo steatosis conditions, offering a new tool for exploring fish intestinal lipid metabolism. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22In+vitro+approaches%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">In vitro approaches</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestinal+steatosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestinal steatosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oleic+acid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oleic acid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rainbow+trout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rainbow trout</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oleic+Acid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oleic Acid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oncorhynchus+mykiss%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oncorhynchus mykiss/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestines%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestines/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Droplets%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Droplets/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Enterocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Enterocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestinal+Mucosa%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestinal Mucosa/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Acids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Acids/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Bradić I</b>, Kuentzel KB, Pirchheim A, Rainer S, Schwarz B, Trauner M, Larsen MR, Vujić N, Kratky D. From LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism. <em class='incite-journal-name' onclick='ShowInCiteJournal(168092);'>Biochim Biophys Acta Mol Cell Biol Lipids</em> 2025;<b>1870</b>:159575. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39486573' target='_blank'>39486573</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbalip.2024.159575' target='_blank'>10.1016/j.bbalip.2024.159575</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbalip.2024.159575','39486573', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbalip.2024.159575' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168092);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.bbalip.2024.159575" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver pathology worldwide, closely associated with obesity and metabolic disorders. Increasing evidence suggests that macrophages play a crucial role in the development of MASLD. Several human studies have shown an inverse correlation between circulating lysosomal acid lipase (LAL) activity and MASLD. LAL is the sole enzyme known to degrade cholesteryl esters (CE) and triacylglycerols in lysosomes. Consequently, these substrates accumulate when their enzymatic degradation is impaired due to LAL deficiency (LALD). This study aimed to investigate the role of hepatic LAL activity and liver-resident macrophages (i.e., Kupffer cells (KC)) in MASLD. To this end, we analyzed lipid metabolism in hepatocyte-specific (hep)Lal-/- mice and depleted KC with clodronate treatment. When fed a high-fat/high-cholesterol diet (HF/HCD), hepLal-/- mice exhibited CE accumulation and an increased number of macrophages in the liver and significant hepatic inflammation. KC were depleted upon clodronate administration, whereas infiltrating/proliferating CD68-expressing macrophages were less affected. This led to exacerbated hepatic CE accumulation and dyslipidemia, as evidenced by increased LDL-cholesterol concentrations. Along with proteomic analysis of liver tissue, these findings indicate that hepatic LAL-D in HF/HCD-fed mice leads to macrophage infiltration into the liver and that KC depletion further exacerbates hepatic CE concentrations and dyslipidemia. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clodronate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clodronate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kupffer+cell+depletion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kupffer cell depletion</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lysosomal+acid+lipase+deficiency%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lysosomal acid lipase deficiency</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+dysfunction-associated+steatotic+liver+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic dysfunction-associated steatotic liver disease</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kupffer+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kupffer Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kupffer+Cells%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kupffer Cells/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sterol+Esterase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sterol Esterase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sterol+Esterase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sterol Esterase/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cholesterol+Esters%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cholesterol Esters/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Fat%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Fat/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocytes%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocytes/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Vaz J</b>, Jepsen P, Strömberg U, Midlöv P, Eriksson B, Buchebner D, Hagström H. Metabolic dysfunction-associated steatotic liver disease has become the most common cause of hepatocellular carcinoma in Sweden: A nationwide cohort study. <em class='incite-journal-name' onclick='ShowInCiteJournal(11478);'>Int J Cancer</em> 2025;<b>156</b>:40-51. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39016032' target='_blank'>39016032</a> DOI: <a href='https://dx.doi.org/10.1002/ijc.35097' target='_blank'>10.1002/ijc.35097</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/ijc.35097','39016032', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(3);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/ijc.35097' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11478);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/18/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1002/ijc.35097" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, and can lead to hepatocellular carcinoma (HCC), a leading cause of cancer-related death. We aimed to determine the extent to which MASLD is an increasing cause of HCC in Sweden and to determine clinical characteristics associated with underlying MASLD. Using the Swedish quality registry for liver cancer (SweLiv), we identified all adults with a diagnosis of HCC in Sweden between 2012 and 2018. Baseline data were retrieved from SweLiv and other nationwide registers. Totally, 3494 patients with HCC were identified. Of them, 757 patients (22%) had MASLD-HCC. The proportion with MASLD-HCC increased from 19% in 2012 to 25% in 2018 (ptrend = 0.012), and MASLD was since 2017 the leading cause of HCC, surpassing hepatitis C. MASLD was the fastest growing cause of HCC with a 33% increment during the study period. Compared to other patients with HCC, those with MASLD-HCC were older (75 vs. 67 years, p < .001), less commonly had cirrhosis (61% vs. 82%, p < .001), had larger tumours (median 5.5 vs. 4.3 cm, p < .001), and more often extrahepatic metastasis (22% vs. 16%, p < .001). Patients with HCC caused by MASLD or by other causes were equally likely to be diagnosed in an early stage (Barcelona Clinic Liver Cancer 0-A, 27% vs. 30%, p = .129). MASLD is now the leading cause of HCC in Sweden. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MASLD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MASLD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22aetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">aetiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cirrhosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cirrhosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hepatocellular+carcinoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hepatocellular carcinoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22steatotic+liver+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">steatotic liver disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22type+2+diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">type 2 diabetes</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Neoplasms%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Neoplasms/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sweden%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sweden/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cohort+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cohort Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%2c+80+and+over%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged, 80 and over</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Registries%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Registries</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Region+of+Halland%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Region of Halland</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Swedish+Gastroenterology+Fund+(Mag-Tarmfonden)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Swedish Gastroenterology Fund (Mag-Tarmfonden)</a></li></ul> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Ezz-Eldin YM</b>, El-Din Ewees MG, Khalaf MM, Azouz AA. Modulation of SIRT6 related signaling pathways of p-AKT/mTOR and NRF2/HO-1 by memantine contributes to curbing the progression of tamoxifen/HFD-induced MASH in rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(8802);'>Eur J Pharmacol</em> 2024;<b>984</b>:177069. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39442744' target='_blank'>39442744</a> DOI: <a href='https://dx.doi.org/10.1016/j.ejphar.2024.177069' target='_blank'>10.1016/j.ejphar.2024.177069</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ejphar.2024.177069','39442744', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ejphar.2024.177069' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8802);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/25/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.ejphar.2024.177069" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic liver disorder marked by hepatic fat accumulation and inflammatory infiltrates which may evolve to cirrhosis. Clinical studies have demonstrated the higher risk of MASH development after tamoxifen (TAM) therapy, especially in obese patients. Therefore, we aimed to evaluate MASH induction by TAM combined with high fat diet (HFD) and the potential interference of memantine (MEMA) with MASH progression via modulation of SIRT6 and its related signaling pathways. MASH was induced in female Wistar rats by co-administration of TAM (25 mg/kg/day, p.o.) and HFD for 5 weeks. Liver function biomarkers, tissue triglyceride and cholesterol, MASH scoring, SIRT6 with its related signals, and lipid synthesis/oxidation markers were estimated. By comparison to MASH group, MEMA improved liver function indices (ALT, AST, ALP, albumin) and reduced the progression of MASH, evidenced by decreased accumulation of lipids in hepatic tissue, improved histological features, and reduced MASH scoring. MEMA enhanced hepatic SIRT6 and downregulated p-AKT/mTOR signaling, that subsequently reduced expressions of the lipid synthesis biomarkers (SREBP1c, SCD), while elevating the lipid oxidation markers (PPAR-α, CPT1). Moreover, MEMA enhanced NRF2/HO-1 signaling, with subsequently improved antioxidant defense and pro-inflammatory/anti-inflammatory cytokines balance. Analysis of SIRT6 correlations with p-AKT/mTOR, NRF2/HO-1, SREBP1c, and PPAR-α further confirmed our results. Consequently, we conclude that MEMA could interfere with MASH progression, at least in part, via enhanced SIRT6 expression and modulation of its related p-AKT/mTOR and NRF2/HO-1 signaling pathways, eventually reducing liver steatosis and inflammation. That could be a promising therapeutic modality for curbing MASH progression. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Memantine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Memantine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NRF2%2fHO-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NRF2/HO-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SIRT6%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SIRT6</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SREBP1c%2fPPAR-%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SREBP1c/PPAR-α</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tamoxifen%2fHFD-Induced+MASH%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tamoxifen/HFD-Induced MASH</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22p-AKT%2fmTOR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">p-AKT/mTOR</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sirtuins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sirtuins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-E2-Related+Factor+2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-E2-Related Factor 2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+c-akt%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins c-akt/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Fat%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Fat/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tamoxifen%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tamoxifen/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Memantine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Memantine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Memantine%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Memantine/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Progression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Heme+Oxygenase+(Decyclizing)%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Heme Oxygenase (Decyclizing)/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/chemically induced</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Pang J</b>, Yin L, Jiang W, Wang H, Cheng Q, Jiang Z, Cao Y, Zhu X, Li B, Qian S, Yin X, Wang T, Lu Q, Yang T. Sirt1-mediated deacetylation of PGC-1α alleviated hepatic steatosis in type 2 diabetes mellitus via improving mitochondrial fatty acid oxidation. <em class='incite-journal-name' onclick='ShowInCiteJournal(5348);'>Cell Signal</em> 2024;<b>124</b>:111478. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39428026' target='_blank'>39428026</a> DOI: <a href='https://dx.doi.org/10.1016/j.cellsig.2024.111478' target='_blank'>10.1016/j.cellsig.2024.111478</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.cellsig.2024.111478','39428026', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.cellsig.2024.111478' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5348);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.cellsig.2024.111478" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Being activated by deacetylation, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) has become an important regulator of metabolic-related diseases. The activation of Sirtuin 1 (Sirt1) by resveratrol was likely to deacetylate PGC-1α. However, the role of deacetylated PGC-1α in the alleviation of activated Sirt1 on type 2 diabetes mellitus (T2DM)-related fatty liver disease (FLD) remained unexplored. The aim of this study was to investigate the potential impact of Sirt1-mediated deacetylation of PGC-1α on T2DM-associated FLD and its underlying mechanisms. Our findings revealed that, along with the decreased Sirt1, the levels of acetylated PGC-1α were up-regulated in hepatocytes co-stimulated with high glucose (HG) and free fatty acids (FFA). Down-regulated Sirt1 inactivated PGC-1α by inhibiting its deacetylation, while activating Sirt1 improved hepatic injury by reducing lipid droplet accumulation through the deacetylation of PGC-1α. However, the beneficial effects of Sirt1 activation on hepatic steatosis were inhibited by PGC-1α antagonist in vitro. Mechanistically, activating Sirt1 enhanced mitochondrial function by promoting PGC-1α activity, thereby facilitating hepatic fatty acid oxidation (FAO). In conclusion, Sirt1-mediated deacetylation of PGC-1α mitigated hepatic lipotoxicity by enhancing mitochondrial FAO, which contributed to the restoration of mitochondrial function in T2DM. The activation of Sirt1-mediated PGC-1α deacetylation might represent a promising therapeutic approach for T2DM-associated FLD. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondrial+FAO%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondrial FAO</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PGC-1%ce%b1+deacetylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PGC-1α deacetylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sirt1+activation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sirt1 activation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T2DM-associated+FLD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T2DM-associated FLD</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peroxisome+Proliferator-Activated+Receptor+Gamma+Coactivator+1-alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sirtuin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sirtuin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Type+2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Type 2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Type+2%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Type 2/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidation-Reduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidation-Reduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acetylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acetylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Acids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Acids/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucose%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucose/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hep+G2+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hep G2 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Li W</b>, Yu L. Role and therapeutic perspectives of extracellular vesicles derived from liver and adipose tissue in metabolic dysfunction-associated steatotic liver disease. <em>ARTIFICIAL CELLS, NANOMEDICINE, AND BIOTECHNOLOGY</em> 2024;<b>52</b>:355-369. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38833340' target='_blank'>38833340</a> DOI: <a href='https://dx.doi.org/10.1080/21691401.2024.2360008' target='_blank'>10.1080/21691401.2024.2360008</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/21691401.2024.2360008','38833340', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/21691401.2024.2360008' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1080/21691401.2024.2360008" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The global epidemic of metabolic diseases has led to the emergence of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), which pose a significant threat to human health. Despite recent advances in research on the pathogenesis and treatment of MASLD/MASH, there is still a lack of more effective and targeted therapies. Extracellular vesicles (EVs) discovered in a wide range of tissues and body fluids encapsulate different activated biomolecules and mediate intercellular communication. Recent studies have shown that EVs derived from the liver and adipose tissue (AT) play vital roles in MASLD/MASH pathogenesis and therapeutics, depending on their sources and intervention types. Besides, adipose-derived stem cell (ADSC)-derived EVs appear to be more effective in mitigating MASLD/MASH. This review presents an overview of the definition, extraction strategies, and characterisation of EVs, with a particular focus on the biogenesis and release of exosomes. It also reviews the effects and potential molecular mechanisms of liver- and AT-derived EVs on MASLD/MASH, and emphasises the contribution and clinical therapeutic potential of ADSC-derived EVs. Furthermore, the future perspective of EV therapy in a clinical setting is discussed. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+dysfunction-associated+steatotic+liver+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic dysfunction-associated steatotic liver disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22adipose+tissue%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">adipose tissue</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22adipose-derived+stem+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">adipose-derived stem cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22extracellular+vesicle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">extracellular vesicle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22liver%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">liver</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Vesicles%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Vesicles/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Lee NY</b>, Koo JH. Longitudinal evaluation of liver stiffness reveals hepatic cholesterol as the determinant of fibrosis progression in mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(16199);'>Life Sci</em> 2024;<b>358</b>:123201. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39486617' target='_blank'>39486617</a> DOI: <a href='https://dx.doi.org/10.1016/j.lfs.2024.123201' target='_blank'>10.1016/j.lfs.2024.123201</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.lfs.2024.123201','39486617', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.lfs.2024.123201' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16199);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.lfs.2024.123201" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">AIMS</div><div class="abstract-content">The metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 30 % of the global population. While excessive consumption of dietary fat induces steatosis, it does not develop fibrosis, indicating that additional factors are required as "second hits" for further progression of MASLD. Here, based on shear wave elastography, we compared the longitudinal patterns of fibrogenesis induced by different diets and show the crucial role of cholesterol accumulation in fibrosis progression. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Mice were fed chow, high-fat (HFD), high-fat high-cholesterol (HFHCD), choline-deficient, L-amino acid-defined high-fat (CDAHFD), or 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine diets over 12 weeks. </div><div class="abstract-label">KEY FINDINGS</div><div class="abstract-content">Mice fed with HFD gained significant amounts of body weight but did not show an increase in liver stiffness. In contrast, the addition of cholesterol in the same diet robustly induced liver stiffening starting from the first week, which was comparable to the CDAHFD-induced fibrosis model. Longitudinal tracking of liver stiffness revealed a two-step progression of fibrosis after prolonged feeding of HFHCD and CDAHFD, likely due to cellular cholesterol accumulation over a certain threshold after the transition point. Biochemical analyses suggested the critical role of both total and hepatic cholesterol accumulation in liver fibrosis development. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">Collectively, our results underscore the significance of cholesterol in liver fibrosis development, also highlighting the benefit of monitoring liver stiffness to understand the pathogenesis of liver fibrosis. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cholesterol%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cholesterol/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Fat%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Fat/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Progression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Elasticity+Imaging+Techniques%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Elasticity Imaging Techniques</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cholesterol%2c+Dietary%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cholesterol, Dietary/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyridines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyridines</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Xiao R</b>, Wang Q, Ni C, Pan W, Wu W, Cai Y, Xie K, You J. Interplay of metabolic dysfunction-associated fatty liver disease and papillary thyroid carcinoma: insights from a Chinese cohort. <em class='incite-journal-name' onclick='ShowInCiteJournal(13657);'>J Endocrinol Invest</em> 2024;<b>47</b>:2943-2952. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38787506' target='_blank'>38787506</a> DOI: <a href='https://dx.doi.org/10.1007/s40618-024-02391-6' target='_blank'>10.1007/s40618-024-02391-6</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s40618-024-02391-6','38787506', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s40618-024-02391-6' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13657);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/jeni/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/25/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1007/s40618-024-02391-6" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">PURPOSE</div><div class="abstract-content">Thyroid cancer is one of a set of extrahepatic cancers that closely linked to metabolic dysfunction-associated fatty liver disease (MAFLD). However, the connection between MAFLD and the characteristics of papillary thyroid cancer (PTC) remains unexplored. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Between Jan 2020 and Oct 2022, surgical cases of PTC patients were examined at the first Affiliated Hospital of Wenzhou Medical University. Clinical data extracted from the electronic medical system underwent a rigorous comparison between two groups, classified based on MAFLD criteria, using logistic regression analysis. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">In this study of 4,410 PTC patients, 18.3% had MAFLD. MAFLD emerged as a distinct risk factor for lymph node metastasis (OR = 1.230, 95% CI 1.018-1.487) in this cohort, especially in females (OR = 1.321, 95% CI 1.026-1.702) and those with BMI ≥ 23 kg/m2 (OR = 1.232, 95% CI 1.004-1.511). The presence of MAFLD was found to significantly elevate the risk of BRAF V600E mutation in both subgroups characterized by FIB-4 score ≥ 1.3 (OR = 1.968, 95% CI 1.107-3.496) and BMI < 23 kg/m2 (OR = 2.584, 95% CI 1.012-6.601). Moreover, among the subset of individuals without non-alcoholic fatty liver disease (NAFLD), it was noted that MAFLD considerably increased the likelihood of tumor multifocality (OR = 1.697, 95% CI 1.111-2.592). Nevertheless, MAFLD did not exhibit any correlation with increased tumor size, extra-thyroidal extension (ETE), or later TNM stage in PTC. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">In this cross-sectional study, we discovered a significant association between MAFLD and increased occurrences of lymph node metastasis. Furthermore, MAFLD was linked to a higher chance of BRAF V600E mutation and the presence of multiple tumors in certain subgroups. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aggressiveness%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aggressiveness</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clinicopathological+features%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clinicopathological features</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAFLD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAFLD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Papillary+thyroid+carcinoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Papillary thyroid carcinoma</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thyroid+Cancer%2c+Papillary%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thyroid Cancer, Papillary/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thyroid+Cancer%2c+Papillary%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thyroid Cancer, Papillary/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thyroid+Cancer%2c+Papillary%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thyroid Cancer, Papillary/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thyroid+Neoplasms%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thyroid Neoplasms/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thyroid+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thyroid Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thyroid+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thyroid Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22China%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">China/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Risk+Factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Risk Factors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+B-raf%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins B-raf/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cohort+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cohort Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphatic+Metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphatic Metastasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Follow-Up+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Follow-Up Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prognosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22East+Asian+People%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">East Asian People</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Scientific+Research+Foundation+of+Wenzhou%2c+Zhejiang+Province%2c+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Y2023156 Scientific Research Foundation of Wenzhou, Zhejiang Province, China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Scientific+Research+Incubator+Project+of+The+First+Affiliated+Hospital+of+Wenzhou+Medical+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FHY2019060 Scientific Research Incubator Project of The First Affiliated Hospital of Wenzhou Medical University</a></li></ul> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Fernandes-da-Silva A</b>, Santana-Oliveira DA, Oliveira ASD, Ferreira TAM, Monteiro NC, Silva-Veiga FM, Martins FF, Cummins CL, Romeiro LAS, Souza-Mello V. LDT409 (pan-PPAR partial agonist) mitigates metabolic dysfunction-associated steatotic liver disease in high-fructose-fed mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(17380);'>Mol Cell Endocrinol</em> 2024;<b>594</b>:112380. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39332468' target='_blank'>39332468</a> DOI: <a href='https://dx.doi.org/10.1016/j.mce.2024.112380' target='_blank'>10.1016/j.mce.2024.112380</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.mce.2024.112380','39332468', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.mce.2024.112380' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17380);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/mce/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/29/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.mce.2024.112380" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">AIM</div><div class="abstract-content">This study sought to evaluate the effects of LDT409, a pan-PPAR partial agonist obtained from the main industrial waste from cashew nut processing, on hepatic remodeling, highlighting energy metabolism and endoplasmic reticulum (ER) stress in high-fructose-fed mice. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Male C57BL/6 mice received a control diet (C) or a high-fructose diet (HFRU) for ten weeks. Then, a five-week treatment started: C, C-LDT409, HFRU, and HFRU-LDT409. The LDT409 (40 mg/kg of body weight) was mixed with the diets. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The HFRU diet caused insulin resistance and endoplasmic reticulum (ER) stress. High Pparg and decreased Ppara expression increased steatosis and pro-fibrogenic gene expression in livers of HFRU-fed mice. Suppressed lipogenic factors, orchestrated by PPAR-gamma, and mitigated ER stress concomitant with the increase in beta-oxidation driven by PPAR-alpha mediated the LDT409 beneficial effects. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">LDT409 may represent a potential low-cost approach to treat metabolic dysfunction-associated steatotic liver disease, which does not currently have a specific treatment. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ER+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ER stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fructose%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fructose</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LDT409%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LDT409</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MASLD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MASLD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PPAR-Alpha%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PPAR-Alpha</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PPAR-Gamma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PPAR-Gamma</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fructose%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fructose/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endoplasmic+Reticulum+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endoplasmic Reticulum Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Insulin+Resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Insulin Resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peroxisome+Proliferator-Activated+Receptors%2fagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peroxisome Proliferator-Activated Receptors/agonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peroxisome+Proliferator-Activated+Receptors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peroxisome Proliferator-Activated Receptors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PPAR+alpha%2fagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PPAR alpha/agonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PPAR+alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PPAR alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PPAR+alpha%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PPAR alpha/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PPAR+gamma%2fagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PPAR gamma/agonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PPAR+gamma%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PPAR gamma/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Ming X</b>, Chen S, Li H, Wang Y, Zeng H, Lv Y. 6-methylcoumarin/miR-122 suppresses hepatic Sortilin-mediated ApoB-100 secretion to attenuate aortic atherosclerosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(5348);'>Cell Signal</em> 2024;<b>124</b>:111384. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39243919' target='_blank'>39243919</a> DOI: <a href='https://dx.doi.org/10.1016/j.cellsig.2024.111384' target='_blank'>10.1016/j.cellsig.2024.111384</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.cellsig.2024.111384','39243919', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.cellsig.2024.111384' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5348);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.cellsig.2024.111384" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study aimed to investigate the effects of hepatic microRNA-122 (miR-122) on Sortilin-mediated apolipoprotein B100 (apoB-100) secretion, and on aortic lipid deposition and atherosclerosis (AS) lesions and to clarify the antiatherosclerotic mechanism of 6-methylcoumarin (6-MC) via the modulation of miR-122. Bioinformatics analysis revealed that miR-122 was putatively overexpressed in a liver-specific manner and was downregulated in steatotic livers. miR-122 was shown to suppress the expression of Sortilin by complementarily pairing to the 3'-untranslated region (3'-UTR) of Sortilin mRNA via bioinformatics and dual-luciferase reporter assays, impeding Sortilin-mediated apoB-100 secretion from HepG2 cells. Administration of 6-MC significantly upregulated hepatocellular miR-122 levels, reducing Sortilin expression and apoB-100 secretion in HepG2 cells. The miR-122 mimic vigorously enhanced 6-MC-depressed Sortilin expression, while miR-122 inhibitor repealed the inhibitory effect of 6-MC on Sortilin expression to some extent in HepG2 cells. After internal intervention with the miR-122 precursor, and 6-MC supplementation alone or in combination with the miR-122 sponge led to the reduction in blood triglyceride (TG) levels, low-density lipoprotein-cholesterol (LDL-C) and apoB-100 and a reduction in aortic lipid deposition and AS lesions in apolipoprotein E-deficient (ApoE-/-) mice fed a high fat diet (HFD). The hepatic levels of Sortilin and apoB-100 expression were also decreased in these treated mice. In conclusion, miR-122 suppresses Sortilin expression and Sortilin-mediated apoB-100 secretion to resist circulating LDL production and aortic AS development, which is enhanced by 6-MC-upregulated miR-122 in the liver. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%226-methylcoumarin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">6-methylcoumarin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apolipoprotein+B-100%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apolipoprotein B-100</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sortilin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sortilin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microRNA-122%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microRNA-122</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apolipoprotein+B-100%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apolipoprotein B-100/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hep+G2+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hep G2 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Vesicular+Transport%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Vesicular Transport/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coumarins%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Coumarins/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aorta%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aorta/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aorta%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aorta/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Fat%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Fat/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Ahn SH</b>, Lee YJ, Lim DS, Cho W, Gwon HJ, Abd El-Aty AM, Jeong JH, Jung TW. Upadacitinib counteracts hepatic lipid deposition via the repression of JAK1/STAT3 signaling and AMPK/autophagy-mediated suppression of ER stress. <em class='incite-journal-name' onclick='ShowInCiteJournal(3277);'>Biochem Biophys Res Commun</em> 2024;<b>735</b>:150829. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39406018' target='_blank'>39406018</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbrc.2024.150829' target='_blank'>10.1016/j.bbrc.2024.150829</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbrc.2024.150829','39406018', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbrc.2024.150829' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3277);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.bbrc.2024.150829" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Upadacitinib (UPA) has been utilized to treat conditions such as rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, and axial spondyloarthritis by modulating inflammation via the JAK pathway. However, its impact on hepatic lipogenesis remains insufficiently studied. This research evaluated protein expression through Western blotting, lipid accumulation with oil red O staining, autophagosomes in hepatocytes via MDC staining, and hepatic apoptosis via cell viability and caspase 3 activity assays. This study aimed to explore the effects of UPA on hepatic lipogenesis and the underlying molecular mechanisms in in vitro models of hepatic steatosis. These findings demonstrated that UPA reduced lipid deposition, apoptosis, and ER stress in palmitate-treated hepatocytes. UPA treatment inhibited phosphorylated JAK1 and STAT3 while promoting the expression of phosphorylated AMPK and autophagy markers. AMPK siRNA negated the effects of UPA on lipogenic lipid deposition, apoptosis, JAK1/STAT3 phosphorylation, and ER stress. These results reveal that UPAmitigates ER stress through the JAK1/STAT3/AMPK pathway, thereby reducing lipid deposition and apoptosis in hyperlipidemic hepatocytes, supporting its potential as a therapeutic strategy for treating hepatic steatosis in obese individuals. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AMPK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AMPK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ER+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ER stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NAFLD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NAFLD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Steatosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Steatosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Upadacitinib%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Upadacitinib</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22STAT3+Transcription+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">STAT3 Transcription Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Janus+Kinase+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Janus Kinase 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endoplasmic+Reticulum+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endoplasmic Reticulum Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Heterocyclic+Compounds%2c+3-Ring%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Heterocyclic Compounds, 3-Ring/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AMP-Activated+Protein+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AMP-Activated Protein Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Metabolism%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Metabolism/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hep+G2+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hep G2 Cells</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Lee HA</b>, Lee HA, Kim HY. Evolution of characteristics of MASLD with and without diabetes: a meta-analysis of placebo arms. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2024;<b>14</b>:28951. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39578601' target='_blank'>39578601</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-024-79428-6' target='_blank'>10.1038/s41598-024-79428-6</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-024-79428-6','39578601', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(12);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-024-79428-6' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/24/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1038/s41598-024-79428-6" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">We explored the changes in metabolic dysfunction-associated steatotic liver disease (MASLD) severity over time by analyzing data from the placebo arms of randomized controlled trials (RCTs), focusing on the presence of diabetes. </div><div class="abstract-label">METHODS</div><div class="abstract-content">RCTs on MASLD that included a placebo arm were identified using a systematic search of the literature. Primary outcomes were changes in hepatic steatosis and fibrosis. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The meta-analysis included 8 RCTs involving 386 patients without diabetes and 24 RCTs involving 637 patients with diabetes. The pooled estimate of mean change in steatosis grade was - 0.1 in patients without diabetes, and - 0.37 in patients with diabetes (P = 0.066). The mean change in fibrosis stage was 0.05 in patients without diabetes, and - 0.03 in patients with diabetes (P = 0.359). The mean change in nonalcoholic fatty liver disease activity score was - 0.55 in patients without diabetes, and - 1.50 in patients with diabetes (P = 0.100). The mean change in ALT and AST were significantly larger in patients without diabetes compared to those with diabetes (P < 0.05). </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Placebo treatment had a greater effect in improving liver steatosis in patients with diabetes compared to those without. These findings highlight the importance of tailored treatment strategies in MASLD, particularly considering diabetes status. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lifestyle+modification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lifestyle modification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+dysfunction-associated+steatotic+liver+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic dysfunction-associated steatotic liver disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+course%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Natural course</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Randomized+controlled+trial%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Randomized controlled trial</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Steatosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Steatosis</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Randomized+Controlled+Trials+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Randomized Controlled Trials as Topic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Placebos%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Placebos</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Severity+of+Illness+Index%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Severity of Illness Index</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministry+of+Science+and+ICT%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2022R1I1A1A01065244 Ministry of Science and ICT</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministry+of+Science+and+ICT%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2018R1A5A2025286 Ministry of Science and ICT</a></li></ul> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Das D</b>, Sharma M, Gahlot D, Nia SS, Gain C, Mecklenburg M, Zhou ZH, Bourdenx M, Thukral L, Martinez-Lopez N, Singh R. VPS4A is the selective receptor for lipophagy in mice and humans. <em class='incite-journal-name' onclick='ShowInCiteJournal(17008);'>Mol Cell</em> 2024;<b>84</b>:4436-4453.e8. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39520981' target='_blank'>39520981</a> DOI: <a href='https://dx.doi.org/10.1016/j.molcel.2024.10.022' target='_blank'>10.1016/j.molcel.2024.10.022</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.molcel.2024.10.022','39520981', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.molcel.2024.10.022' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17008);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.molcel.2024.10.022" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Lipophagy is a ubiquitous mechanism for degradation of lipid droplets (LDs) in lysosomes. Autophagy receptors selectively target organelles for lysosomal degradation. The selective receptor for lipophagy remains elusive. Using mouse liver phosphoproteomics and human liver transcriptomics, we identify vacuolar-protein-sorting-associated protein 4A (VPS4A), a member of a large family AAA+ ATPases, as a selective receptor for lipophagy. We show that phosphorylation of VPS4A on Ser95,97 and its localization to LDs in response to fasting drives lipophagy. Imaging/three-dimensional (3D) reconstruction and biochemical analyses reveal the concomitant degradation of VPS4A and LDs in lysosomes in an autophagy-gene-7-sensitive manner. Either silencing VPS4A or targeting VPS4AS95,S97 phosphorylation or VPS4A binding to LDs or LC3 blocks lipophagy without affecting other forms of selective autophagy. Finally, VPS4A levels and markers of lipophagy are markedly reduced in human steatotic livers-revealing a fundamental role of VPS4A as the lipophagy receptor in mice and humans. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MASLD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MASLD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22VPS4A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">VPS4A</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22human%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">human</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lipid+droplet%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lipid droplet</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lipophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lipophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22liver%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">liver</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lysosome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lysosome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22phosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">phosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">receptor</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATPases+Associated+with+Diverse+Cellular+Activities%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATPases Associated with Diverse Cellular Activities/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATPases+Associated+with+Diverse+Cellular+Activities%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATPases Associated with Diverse Cellular Activities/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lysosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lysosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lysosomes%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lysosomes/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Droplets%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Droplets/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microtubule-Associated+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microtubule-Associated Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microtubule-Associated+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microtubule-Associated Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vacuolar+Proton-Translocating+ATPases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vacuolar Proton-Translocating ATPases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endosomal+Sorting+Complexes+Required+for+Transport%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endosomal Sorting Complexes Required for Transport</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Zhang N</b>, Liu J, Guo R, Yan L, Yang Y, Shi C, Zhang M, Shan B, Li W, Gu J, Xu D. Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(17008);'>Mol Cell</em> 2024;<b>84</b>:4419-4435.e10. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39471814' target='_blank'>39471814</a> DOI: <a href='https://dx.doi.org/10.1016/j.molcel.2024.10.002' target='_blank'>10.1016/j.molcel.2024.10.002</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.molcel.2024.10.002','39471814', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.molcel.2024.10.002' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17008);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/01/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.molcel.2024.10.002" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Tumor necrosis factor (TNF)-induced receptor-interacting serine/threonine protein kinase 1 (RIPK1)-mediated cell death, including apoptosis and necroptosis, is increasingly recognized as a major driver of inflammatory diseases. Cell death checkpoints normally suppress RIPK1 kinase to safeguard the organism from its detrimental consequences. However, the mechanisms licensing RIPK1 kinase activity when a protective checkpoint is disabled remain unclear. Here, we identified S-palmitoylation as a licensing modification for RIPK1 kinase. TNF induces RIPK1 palmitoylation, mediated by DHHC5 and dependent on K63-linked ubiquitination of RIPK1, which enhances RIPK1 kinase activity by promoting the homo-interaction of its kinase domain and promotes cell death upon cell death checkpoint blockade. Furthermore, DHHC5 is amplified by fatty acid in the livers of mice with metabolic dysfunction-associated steatohepatitis, contributing to increased RIPK1 cytotoxicity observed in this condition. Our findings reveal that ubiquitination-dependent palmitoylation licenses RIPK1 kinase activity to induce downstream cell death signaling and suggest RIPK1 palmitoylation as a feasible target for inflammatory diseases. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DHHC5%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DHHC5</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RIPK1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RIPK1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TNF+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TNF pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metabolic+dysfunction-associated+steatohepatitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metabolic dysfunction-associated steatohepatitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22necroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">necroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoyl+acyltransferase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoyl acyltransferase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor-Interacting+Protein+Serine-Threonine+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor-Interacting Protein Serine-Threonine Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor-Interacting+Protein+Serine-Threonine+Kinases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor-Interacting Protein Serine-Threonine Kinases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ubiquitination%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ubiquitination</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factor-alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factor-alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HEK293+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HEK293 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fenzymology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/enzymology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fenzymology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/enzymology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Necroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Necroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Li YN</b>, Sun FF, Ouyang F, Luo D, Zhang ZX, Lu MX, Hu CY, Shi YH, Gui Q, Zhang JY, Yang TS. Alterations in liver triglyceride profiles in CCl<sub>4</sub>-induced liver regeneration. <em class='incite-journal-name' onclick='ShowInCiteJournal(3277);'>Biochem Biophys Res Commun</em> 2024;<b>734</b>:150662. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39245030' target='_blank'>39245030</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbrc.2024.150662' target='_blank'>10.1016/j.bbrc.2024.150662</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbrc.2024.150662','39245030', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbrc.2024.150662' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3277);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1016/j.bbrc.2024.150662" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Lipid metabolism, particularly triglyceride (TG) metabolism, is crucial for liver regeneration. During the early phase of liver regeneration, the liver temporarily accumulates a substantial amount of TG-dominated lipids. However, the specific composition of the TG profile during this phase is not yet fully understood. Here, we showed that the TG molecular composition in the liver was significantly altered during liver regeneration following carbon tetrachloride (CCl4)-induced liver injury. Lipid accumulation in livers was observed as early as 12 hours after CCl4 treatment, with transient regeneration-associated steatosis (TRAS) lasting until 24 hours. Hepatocyte proliferation began only after liver lipid levels returned to baseline at 48 hours. Furthermore, the profile of TG species changed significantly during liver regeneration. During the TRAS period, the accumulated TGs in the liver were mainly long-chain triglycerides, with most of the fatty acids constituting these triglycerides having fewer than 20 carbon atoms. In the proliferation phase, the fatty acid composition of these triglycerides shifted from long-chain to ultra-long-chain fatty acids. Our results suggest a significant TRAS-related change in the TG lipid profile of the liver during liver regeneration. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+acid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty acid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TRAS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TRAS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Triglyceride+composition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Triglyceride composition</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Regeneration/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Triglycerides%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Triglycerides/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carbon+Tetrachloride%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carbon Tetrachloride/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Metabolism%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Metabolism/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Acids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Acids/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Sabatini S</b>, Sen P, Carli F, Pezzica S, Rosso C, Lembo E, Verrastro O, Daly A, Govaere O, Cockell S, Hyötyläinen T, Mingrone G, Bugianesi E, Anstee QM, Orešič M, Gastaldelli A. Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis. <em class='incite-journal-name' onclick='ShowInCiteJournal(171780);'>Cell Rep Med</em> 2024;<b>5</b>:101820. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39566466' target='_blank'>39566466</a> DOI: <a href='https://dx.doi.org/10.1016/j.xcrm.2024.101820' target='_blank'>10.1016/j.xcrm.2024.101820</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.xcrm.2024.101820','39566466', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.xcrm.2024.101820' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(171780);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/25/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1016/j.xcrm.2024.101820" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are associated with a high prevalence of type 2 diabetes (T2D). Individuals with MASLD exhibit insulin resistance (IR) and hyperglycemia, but it is unclear whether hepatic glucose production (HGP) is increased with MASLD severity. We evaluated HGP in a cohort of histologically characterized individuals with MASL/MASH using stable isotope infusion (6,6-2H2-glucose, U-2H5-glycerol) and liver-specific genome-scale metabolic models (GEMs). Tracer-measured HGP is increased with liver fibrosis and inflammation, but not steatosis, and is associated with lipolysis and IR. The GEM-derived gluconeogenesis is elevated due to high glucogenic/energy metabolite uptakes (lactate, glycerol, and free fatty acid [FFA]), and the expression of insulin action genes (IRS1, IRS2, and AKT2) is reduced in MASH with fibrosis F2-F4, with/without T2D, suggesting these as putative mechanisms for increased fasting HGP and hyperglycemia. In conclusion, elevated HGP, lipolysis, and IR help to explain the mechanisms for the increased risk of hyperglycemia and T2D in MASH. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MASH%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MASH</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MASLD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MASLD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NASH%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NASH</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22fluxomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">fluxomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genome-scale+metabolic+modeling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genome-scale metabolic modeling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gluconeogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gluconeogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hepatic+glucose+production%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hepatic glucose production</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22insulin+resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">insulin resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22liver+fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">liver fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22type+2+diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">type 2 diabetes</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucose%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucose/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Insulin+Resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Insulin Resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipolysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipolysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Type+2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Type 2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Type+2%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Type 2/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Type+2%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Type 2/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Type+2%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Type 2/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gluconeogenesis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gluconeogenesis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Insulin+Receptor+Substrate+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Insulin Receptor Substrate Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Insulin+Receptor+Substrate+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Insulin Receptor Substrate Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Insulin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Insulin/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Lee YK</b>, Lee DH, Joo SK, Jang H, So YH, Jang S, Lee DH, Park JH, Chang MS, Kim W. Combi-Elastography versus Transient Elastography for Assessing the Histological Severity of Metabolic Dysfunction-Associated Steatotic Liver Disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(10006);'>Gut Liver</em> 2024;<b>18</b>:1048-1059. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39469729' target='_blank'>39469729</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565001' target='_blank'>PMC11565001</a> DOI: <a href='https://dx.doi.org/10.5009/gnl240198' target='_blank'>10.5009/gnl240198</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.5009/gnl240198','39469729', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(17);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.5009/gnl240198' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10006);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/gnl/default.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/30/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.5009/gnl240198" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background/Aims</div><div class="abstract-content">Combi-elastography is a B-mode ultrasound-based method in which two elastography modalities are utilized simultaneously to assess metabolic dysfunction-associated steatotic liver disease (MASLD). However, the performance of combi-elastography for diagnosing metabolic dysfunction-associated steatohepatitis (MASH) and determining fibrosis severity is unclear. This study compared the diagnostic performances of combi-elastography and vibration-controlled transient elastography (VCTE) for identifying hepatic steatosis, fibrosis, and high-risk MASH. </div><div class="abstract-label">Methods</div><div class="abstract-content">Participants who underwent combi-elastography, VCTE, and liver biopsy were selected from a prospective cohort of patients with clinically suspected MASLD. Combi-elastography-related parameters were acquired, and their performances were evaluated using area under the receiver-operating characteristic curve (AUROC) analysis. </div><div class="abstract-label">Results</div><div class="abstract-content">A total of 212 participants were included. The diagnostic performance for hepatic steatosis of the attenuation coefficient adjusted by covariates from combi-elastography was comparable to that of the controlled attenuation parameter measured by VCTE (AUROC, 0.85 vs 0.85; p=0.925). The performance of the combi-elastography-derived fibrosis index adjusted by covariates for diagnosing significant fibrosis was comparable to that of liver stiffness measured by VCTE (AUROC, 0.77 vs 0.80; p=0.573). The activity index from combi-elastography adjusted by covariates was equivalent to the FibroScan-aspartate aminotransferase score in diagnosing high-risk MASH among participants with MASLD (AUROC, 0.72 vs 0.74; p=0.792). </div><div class="abstract-label">Conclusions</div><div class="abstract-content">The performance of combi-elastography is similar to that of VCTE when evaluating histology of MASLD. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Elasticity+imaging+techniques%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Elasticity imaging techniques</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+dysfunction-associated+steatohepatitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic dysfunction-associated steatohepatitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+dysfunction-associated+steatotic+liver+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic dysfunction-associated steatotic liver disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ultrasonography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ultrasonography</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Elasticity+Imaging+Techniques%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Elasticity Imaging Techniques/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Severity+of+Illness+Index%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Severity of Illness Index</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROC+Curve%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROC Curve</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biopsy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biopsy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Research Foundation of Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministry+of+Science+and+ICT%2c+South+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ministry of Science and ICT, South Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seoul+National+University+Hospital%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seoul National University Hospital</a></li></ul> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Diab F</b>, Zbeeb H, Zeaiter L, Baldini F, Pagano A, Minicozzi V, Vergani L. Unraveling the metabolic activities of bioactive compounds on cellular models of hepatosteatosis and adipogenesis through docking analysis with PPARs. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2024;<b>14</b>:28196. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39548141' target='_blank'>39548141</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568224' target='_blank'>PMC11568224</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-024-78374-7' target='_blank'>10.1038/s41598-024-78374-7</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-024-78374-7','39548141', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(18);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-024-78374-7' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/17/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1038/s41598-024-78374-7" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Obesity is associated with fatty liver disease. Available therapies show modest efficacy, and nutraceuticals with good effectiveness and safety are largely investigated. We focused on five natural compounds, three plant phenolic compounds (carvacrol, rosmarinic acid, silybin), and two thyroid hormones (T2: 3,5-diiodo-l-thyronine; T3: 3,5,3'-triiodo-L-thyronine) as comparison, to assess their beneficial effects on two cellular models of hepatosteatosis and adipogenesis. All compounds ameliorated the lipid accumulation and oxidative stress in both models, but with different potencies. The peroxisome proliferator-activated receptors (PPARs) are pivotal controllers of adipogenesis and lipid metabolism. For the main isoforms, PPARγ and PPARa, we assessed their possible binding to the compounds by molecular docking calculations, and their expression pattern by real-time PCR. All compounds bind both PPARs with different affinity, while not all compounds affect their expression. The results may clarify the distinctive molecular mechanisms underlying the action of the five compounds in the different cell models with possible applications to treat obesity. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatosteatosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatosteatosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+activities%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic activities</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Docking%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Docking</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+products%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Natural products</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nuclear+receptors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nuclear receptors</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Docking+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Docking Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PPAR+gamma%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PPAR gamma/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Metabolism%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Metabolism/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peroxisome+Proliferator-Activated+Receptors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peroxisome Proliferator-Activated Receptors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cinnamates%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cinnamates/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cinnamates%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cinnamates/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cinnamates%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cinnamates/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%223T3-L1+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">3T3-L1 Cells</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PRIMA+2022-B4HT_Prima+2022_00124%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CUP D33C22002150007 PRIMA 2022-B4HT_Prima 2022_00124</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PRIMA+2022-B4HT_Prima+2022_00124%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CUP D33C22002150007 PRIMA 2022-B4HT_Prima 2022_00124</a></li></ul> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Wang Z</b>, Wan X, Khan MA, Peng L, Sun X, Yi X, Chen K. NAT10 promotes liver lipogenesis in mouse through N4-acetylcytidine modification of Srebf1 and Scap mRNA. <em class='incite-journal-name' onclick='ShowInCiteJournal(16089);'>Lipids Health Dis</em> 2024;<b>23</b>:368. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39529018' target='_blank'>39529018</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552140' target='_blank'>PMC11552140</a> DOI: <a href='https://dx.doi.org/10.1186/s12944-024-02360-1' target='_blank'>10.1186/s12944-024-02360-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s12944-024-02360-1','39529018', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(19);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s12944-024-02360-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/fe3470bb50954e838e85e54a2c6d06b0/12944_2024_Article_2360.PMC11552140.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1186/s12944-024-02360-1');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16089);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1186/s12944-024-02360-1" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Metabolic dysfunction associated steatotic liver disease (MASLD), closely linked to excessive lipogenesis, induces chronic liver disease. MASLD often cause other metabolic diseases, such as cardiovascular disease, diabetes and obesity. However, the mechanism of N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) mRNA modification in lipogenesis of MASLD has not been fully elucidated. This study investigated the role of NAT10 in lipogenesis targeting mRNA ac4C modification. </div><div class="abstract-label">METHODS</div><div class="abstract-content">The expression of NAT10 in mouse liver was assessed after a 12-week high-fat diet. In addition, the expression of NAT10 also was detected after AML12 hepatocytes cells were treated with 150 µmol/L palmitic acid (PA). The ac4C mRNA modification was performed by dot blotting. Oil red O staining and the mRNA expression of Srebf1, Acaca and Fasn were used to assess lipogenesis in AML12 cells with NAT10 overexpression or knockdown. acRIP-PCR and NAT10 RIP-PCR were used to verify the Srebf1 and Scap mRNA ac4C modification by NAT10. Furthermore, the liver lipogenesis was evaluated by AAV-mediated target knockdown of NAT10 in mouse liver and treating a specific inhibitor, Remodelin. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">This study revealed that NAT10 is significantly upregulated in liver lipogenesis after a 12-week high-fat diet. NAT10 and ac4C mRNA modification were also drastically increased in AML12 cells after treated with 150 µmol/L PA. Silencing of NAT10 notably inhibited the lipogenesis in AML12 cells and AAV-mediated target knockdown of NAT10 in mouse liver. The acRIP-PCR and NAT10-RIP-PCR revealed that NAT10 ac4C modified Srebf1 and Scap mRNA, the critical modulator of liver lipogenesis, to regulate liver lipogenesis. Besides, Remodelin strongly inhibited liver lipogenesis, including liver TG, serum ALT, AST, TG and TC level and glucose metabolism. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">NAT10 mediates ac4C modification of Srebf1 and Scap mRNA, thereby affecting lipogenesis in the liver. This study provided a new target for the treatment of MASLD. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%5cn++++++++++++++++++++++++Scap%5cn+++++++++++++++++++++%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"> Scap </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%5cn++++++++++++++++++++++++Srebf1%5cn+++++++++++++++++++++%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"> Srebf1 </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+lipogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver lipogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22N-acetyltransferase+10%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">N-acetyltransferase 10</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ac4C+modification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ac4C modification</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipogenesis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipogenesis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sterol+Regulatory+Element+Binding+Protein+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sterol Regulatory Element Binding Protein 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sterol+Regulatory+Element+Binding+Protein+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sterol Regulatory Element Binding Protein 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Fat%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Fat/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22N-Terminal+Acetyltransferase+E%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">N-Terminal Acetyltransferase E/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22N-Terminal+Acetyltransferase+E%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">N-Terminal Acetyltransferase E/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytidine%2fanalogs+%26amp%3b+derivatives%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytidine/analogs & derivatives</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytidine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytidine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Palmitic+Acid%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Palmitic Acid/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22N-Terminal+Acetyltransferases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">N-Terminal Acetyltransferases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22N-Terminal+Acetyltransferases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">N-Terminal Acetyltransferases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Health+Research+Project+of+Hunan+Provincial+Health+Commission%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">W20243129 Health Research Project of Hunan Provincial Health Commission</a></li></ul> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Chang JS</b>, Ahn JH, Kim MY, Park KS. Elevated serum growth differentiation factor 15 and decorin predict the fibrotic progression of metabolic dysfunction-associated steatotic liver disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2024;<b>14</b>:27527. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39528512' target='_blank'>39528512</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554648' target='_blank'>PMC11554648</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-024-77719-6' target='_blank'>10.1038/s41598-024-77719-6</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-024-77719-6','39528512', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(20);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-024-77719-6' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/9f2f68f3e506a230710fe7dfc29664ab/41598_2024_Article_77719.PMC11554648.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1038/s41598-024-77719-6');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1038/s41598-024-77719-6" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Mitochondrial dysfunction with oxidative stress contributes to metabolic dysfunction-associated steatotic liver disease (MASLD) progression. We aimed to evaluate the fibrosis predictive efficacy of a novel non-invasive diagnostic panel using metabolic stress biomarkers. From a population-based general cohort, 144 subjects with MASLD were recruited in the development group and underwent magnetic resonance imaging-based liver examinations, anthropometric and laboratory tests. As an external validation group, 41 patients enrolled in a biopsy-evaluated MASLD cohort participated in this study. Liver fat content and stiffness were measured by magnetic resonance (MR) imaging-proton density fat fraction and MR elastography (MRE), respectively. Serologic stress biomarkers were quantitated by ELISA. Multivariate regression showed that waist-to-height ratio, growth differentiation factor-15 (GDF15), γ-glutamyltransferase, decorin, and alkaline-phosphatase were independent predictors of hepatic fibrosis (rank-ordered by Wald). The area under receiver-operator characteristics curve [AUROC (95% CI)) of the metabolic stress index for fibrosis (MSI-F) was 0.912 (0.85‒0.98) and 0.977 (0.92‒1.00) in development and validation groups, respectively. MSI-F also had better diagnostic accuracy (82.6‒92.4%) than other fibrosis indices in the both study cohorts. MSI-F consistently differentiated fibrosis severities across cohorts of MRE-evaluated general population and biopsy-proven patients with MASLD, while other indices showed no or less discrimination. MSI-F, as a novel non-invasive index based on a stress-stimulated protective hormone GDF15 and decorin, effectively predicted hepatic fibrosis. Furthermore, MSI-F may serve as pre-screening tool to increase the population that could be excluded from further evaluation, reducing unnecessary invasive investigations more effectively than other indices. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Decorin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Decorin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Growth+differentiation+factor-15%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Growth differentiation factor-15</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatic+fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatic fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondrial+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondrial stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Serum+biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Serum biomarker</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Growth+Differentiation+Factor+15%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Growth Differentiation Factor 15/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Decorin%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Decorin/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Decorin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Decorin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Progression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROC+Curve%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROC Curve</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Elasticity+Imaging+Techniques%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Elasticity Imaging Techniques</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NRF-2018R1C1B6005036 National Research Foundation of Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NRF-2017R1A5A2015369 National Research Foundation of Korea</a></li></ul> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Kim S</b>, Jeong N, Park J, Noh H, Lee JO, Yu SJ, Ku JL. Establishment and characterization of mouse metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma organoids. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2024;<b>14</b>:27460. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39523389' target='_blank'>39523389</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551198' target='_blank'>PMC11551198</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-024-78963-6' target='_blank'>10.1038/s41598-024-78963-6</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-024-78963-6','39523389', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(21);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-024-78963-6' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/321b4be9d866dcbff8a1d446ce22d4b8/41598_2024_Article_78963.PMC11551198.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1038/s41598-024-78963-6');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1038/s41598-024-78963-6" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Metabolic dysfunction-associated steatohepatitis (MASH) is a form of chronic liver inflammation associated with metabolic syndrome, such as obesity and a major cause of hepatocellular carcinoma (HCC). Multi-biotics, a soymilk fermented with lactic acid bacteria, are known to alleviate obesity by lowering lipid profile. This study aimed to establish and characterize mouse organoids derived from MASH-related HCC models to evaluate drug responses, particularly focusing on Lenvatinib resistance. Organoids were developed using mouse liver tissues subjected to a choline-deficient L-amino acid-defined high-fat diet (CDAHFD) to mimic MASH-related HCC. The study evaluated the effect of multi-biotics, a fermented product, on tumor regression and drug sensitivity. While multi-biotics did not reduce tumor burden, they enhanced the response to Lenvatinib. Additionally, repeated treatment with Lenvatinib led to the development of drug-resistant organoids. Transcriptomic analysis of these resistant organoids identified key pathways related to KRAS signaling, inflammation, and epithelial-mesenchymal transition (EMT), revealing potential targets for overcoming Lenvatinib resistance. This study provides valuable insights into MASH-related HCC progression and drug resistance, offering a model for further therapeutic research. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Choline-deficient+L-amino+acid-defined+high-fat+diet+(CDAHFD)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Choline-deficient L-amino acid-defined high-fat diet (CDAHFD)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocellular+carcinoma+(HCC)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocellular carcinoma (HCC)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lenvatinib%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lenvatinib</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+dysfunction-associated+steatohepatitis+(MASH)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic dysfunction-associated steatohepatitis (MASH)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multi-biotics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multi-biotics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Organoid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Organoid</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Organoids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Organoids/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Organoids%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Organoids/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Quinolines%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Quinolines/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenylurea+Compounds%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenylurea Compounds/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Fat%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Fat/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistance%2c+Neoplasm%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistance, Neoplasm</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelial-Mesenchymal+Transition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelial-Mesenchymal Transition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2021M3H9A1030151 National Research Foundation of Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2021M3H9A1030151 National Research Foundation of Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2021M3H9A1030151 National Research Foundation of Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2021M3H9A1030151 National Research Foundation of Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2021M3H9A1030151 National Research Foundation of Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2021M3H9A1030151 National Research Foundation of Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2021M3H9A1030151 National Research Foundation of Korea</a></li></ul> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Porto-Barbosa T</b>, Ramos LF, Pansa CC, Molica LR, Malaspina O, Moraes KCM. Inhibition of the miR-1914-5p increases the oxidative metabolism in cellular model of steatosis by modulating the Sirt1-PGC-1α pathway and systemic cellular activity. <em class='incite-journal-name' onclick='ShowInCiteJournal(19324);'>PLoS One</em> 2024;<b>19</b>:e0313185. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39514580' target='_blank'>39514580</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11548759' target='_blank'>PMC11548759</a> DOI: <a href='https://dx.doi.org/10.1371/journal.pone.0313185' target='_blank'>10.1371/journal.pone.0313185</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1371/journal.pone.0313185','39514580', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(22);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1371/journal.pone.0313185' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(19324);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1371/journal.pone.0313185" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Metabolic associated fatty liver disease (MAFLD) is considered an indicator of metabolic syndrome, which affects millions of people around the world and no effective treatment is currently available. MAFLD involves a wide spectrum of liver damage, that initiates from steatosis (fatty live) and may progress to more complex pathophysiology. Then, details in lipid metabolism controlling should be explored aiming to control the fatty liver. In this context, the miR-1914-5p can be considered a potential biotechnology tool to control lipid metabolism in hepatic cells. This miRNA finds potential mRNA binding sequences in more than 100 molecules correlated with energy production and lipid metabolism pointed in bioinformatic platforms. The present study addressed the miR-1914-5p effects in hepatic HepG2/LX-2 co-cultured cells in a in vitro steatotic environment stablished by the addition of 400 μM of a mixture of oleic and palmitic acids. The analyses demonstrated that the inhibition of the miRNA reduced energetic metabolites such as total lipids, triglycerides, cholesterol and even glucose. In addition, the miR-inhibitor-transfected cells did not present any deleterious effect in cellular environment by controlling reactive oxygen species production (ROS), mitochondrial membrane potential (ΔΨm) and even the pro-inflammatory environment. Moreover, the functional effect of the investigated miR, suggested its close connection to the modulation of Sirt-1-PGC1-α pathway, a master switch metabolic route that controlls cellular energetic metabolism. Our assays also suggested a synergistic effect of this miR-1914-5p in cell metabolism, which should be considered as a strong candidate to control steatotic environment in future clinical trials. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sirtuin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sirtuin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sirtuin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sirtuin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peroxisome+Proliferator-Activated+Receptor+Gamma+Coactivator+1-alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peroxisome+Proliferator-Activated+Receptor+Gamma+Coactivator+1-alpha%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hep+G2+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hep G2 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Potential%2c+Mitochondrial%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Potential, Mitochondrial</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Funda%c3%a7%c3%a3o+de+Amparo+%c3%a0+Pesquisa+do+Estado+de+S%c3%a3o+Paulo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fundação de Amparo à Pesquisa do Estado de São Paulo</a></li></ul> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Hur S</b>, Jeong H, Kim K, Kim KH, Kim SH, Lee Y, Nam KT. MIST1 regulates endoplasmic reticulum stress-induced hepatic apoptosis as a candidate marker of fatty liver disease progression. <em class='incite-journal-name' onclick='ShowInCiteJournal(4705);'>Cell Death Dis</em> 2024;<b>15</b>:805. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39516480' target='_blank'>39516480</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549289' target='_blank'>PMC11549289</a> DOI: <a href='https://dx.doi.org/10.1038/s41419-024-07217-0' target='_blank'>10.1038/s41419-024-07217-0</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41419-024-07217-0','39516480', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(23);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41419-024-07217-0' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1038/s41419-024-07217-0');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4705);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1038/s41419-024-07217-0" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The liver regenerates after injury; however, prolonged injury can lead to chronic inflammation, fatty liver disease, fibrosis, and cancer. The mechanism involving the complex pathogenesis of the progression of liver injury to chronic liver disease remains unclear. In this study, we investigated the dynamics of gene expression associated with the progression of liver disease. We analyzed changes in gene expression over time in a mouse model of carbon tetrachloride (CCl4)-induced fibrosis using high-throughput RNA sequencing. Prolonged CCl4-induced liver injury increased the expression levels of genes associated with the unfolded protein response (UPR), which correlated with the duration of injury, with substantial, progressive upregulation of muscle, intestine, and stomach expression 1 (Mist1, bhlha15) in the mouse fibrosis model and other liver-damaged tissues. Knockdown of MIST1 in HepG2 cells decreased tribbles pseudokinase 3 (TRIB3) levels and increased apoptosis, consistent with the patterns detected in Mist1-knockout mice. MIST1 expression was confirmed in liver tissues from patients with metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis (MASH) and correlated with disease progression. In conclusion, MIST1 is expressed in hepatocytes in response to damage, suggesting a new indicator of liver disease progression. Our results suggest that MIST1 plays a key role in the regulation of apoptosis and TRIB3 expression contributing to progressive liver disease after injury. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22non-alcoholic+fatty+liver+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">non-alcoholic fatty liver disease</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endoplasmic+Reticulum+Stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endoplasmic Reticulum Stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Progression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Cycle+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Cycle Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Cycle+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Cycle Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carbon+Tetrachloride%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carbon Tetrachloride</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basic+Helix-Loop-Helix+Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Basic Helix-Loop-Helix Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basic+Helix-Loop-Helix+Transcription+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Basic Helix-Loop-Helix Transcription Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Serine-Threonine+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Serine-Threonine Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Serine-Threonine+Kinases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Serine-Threonine Kinases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hep+G2+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hep G2 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Unfolded+Protein+Response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Unfolded Protein Response</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocytes%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocytes/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22This+research+was+supported+by+the+National+Research+Foundation+(NRF)+funded+by+the+Ministry+of+Science+%26amp%3b+ICT+(RS-2023-00241446)+(KTN)%2c+the+Bio+%26amp%3b+Medical+Technology+Development+Program+of+the+NRF+funded+by+the+Korean+government+(MSIT)+(No.+2022R1A2C3007850+to+KTN)%2c+NRF+grants+funded+by+the+Korean+government+(No.+RS-2024-00400118+to+KTN%2c+No.+2022M3A9F3016364+to+KTN)%2c+and+the+Nano+%26amp%3b+Material+Technology+Development+Program+through+the+NRF+funded+by+Ministry+of+Science+and+ICT(RS-2024-00407093).%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">This research was supported by the National Research Foundation (NRF) funded by the Ministry of Science & ICT (RS-2023-00241446) (KTN), the Bio & Medical Technology Development Program of the NRF funded by the Korean government (MSIT) (No. 2022R1A2C3007850 to KTN), NRF grants funded by the Korean government (No. RS-2024-00400118 to KTN, No. 2022M3A9F3016364 to KTN), and the Nano & Material Technology Development Program through the NRF funded by Ministry of Science and ICT(RS-2024-00407093).</a></li></ul> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Tian P</b>, Tian X, Gao L, Ma C, Liang X. Early-life antibiotic exposure aggravate the metabolic dysfunction-associated steatotic liver disease associated hepatocellular carcinoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(3771);'>BMC Cancer</em> 2024;<b>24</b>:1358. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39506660' target='_blank'>39506660</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539558' target='_blank'>PMC11539558</a> DOI: <a href='https://dx.doi.org/10.1186/s12885-024-13136-2' target='_blank'>10.1186/s12885-024-13136-2</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s12885-024-13136-2','39506660', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s12885-024-13136-2' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3771);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/08/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1186/s12885-024-13136-2" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Metabolic dysfunction-associated steatotic liver disease (MASLD) asscociated hepatocellular carcinoma (HCC) is becoming a growing concern in global healthcare. The early-life gut microbiota plays a crucial role in maintaining healthy. However, the impact of early-life gut microbiota dysbiosis on the advancement of MASLD-HCC remains inadequately understood. </div><div class="abstract-label">METHODS</div><div class="abstract-content">In the present study, we investigated the role of early-life gut microbiota in the development of MASLD-HCC in streptozotocin and high-fat diet (STZ-HFD) induced mouse model. We recorded the body weight and lifespan, and dynamically monitored the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (T-CHO) and blood glucose in the serum monthly. In addition, we examined various immune cells present in the liver, such as T cells, B cells, NK cells, NKT cells, αβT cells, γδT cells, macrophage and MDSC cells by flow cytometry and conducted liquid chromatography mass spectrometry (LC-MS) based analysis on liver tissue from control and early-life antibiotic exposure mice (early-Abx) MASLD-HCC mice. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">We found that early-Abx mice suffered from more severe tumor burden and further confirmed that hepatocytes and immune cells were all disturbed. Importantly, early-life antibiotic exposure alters the liver metabolic profiling especially glycerophospholipids and lipid accumulation. Furthermore, mice exposed to antibiotics in early-life showed disturbances in glucose metabolism and developed insulin resistance. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Collectively, our findings revealed that early-life antibiotic exposure accelerated the progression of MASLD-HCC by impairing the hepatocytes, immune homeostasis and metabolites persistently, highlighting the importance of the early-life microbiota in the development of MASLD-HCC. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Early-life+antibiotic+exposure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Early-life antibiotic exposure</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+dysfunction-associated+steatotic+liver+disease+associated+hepatocellular+carcinoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic dysfunction-associated steatotic liver disease associated hepatocellular carcinoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolites%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolites</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Bacterial+Agents%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Bacterial Agents/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Neoplasms%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Neoplasms/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Neoplasms%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Neoplasms/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Fat%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Fat/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dysbiosis%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dysbiosis/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Streptozocin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Streptozocin</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Kuru Öz D</b>, Ellik Z, Gürsoy Çoruh A, Adıgüzel M, Gümüşsoy M, Kiremitci S, Kırımker OE, Gökcan H, Elhan AH, Balcı D, Savaş B, Erden A, İdilman R. Assessing hepatic steatosis by magnetic resonance in potential living liver donors. <em class='incite-journal-name' onclick='ShowInCiteJournal(7763);'>Diagn Interv Radiol</em> 2024;<b>30</b>:351-356. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38737404' target='_blank'>38737404</a> DOI: <a href='https://dx.doi.org/10.4274/dir.2024.242697' target='_blank'>10.4274/dir.2024.242697</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.4274/dir.2024.242697','38737404', 'Fatty Liver/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.4274/dir.2024.242697' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7763);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/14/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.4274/dir.2024.242697" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">PURPOSE</div><div class="abstract-content">To determine the accuracy of magnetic resonance imaging-proton density fat fraction (MRI-PDFF) measurements for detecting liver fat content in potential living liver donors and to compare these results using liver biopsy findings. </div><div class="abstract-label">METHODS</div><div class="abstract-content">A total of 139 living liver donors (men/women: 83/56) who underwent MRI between January 2017 and September 2021 were included in this analysis retrospectively. The PDFFs were measured using both MR spectroscopy (MRS) and chemical shift-based MRI (CS-MRI) for each donor in a blinded manner. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Significant positive correlations were found between liver biopsy and MRS-PDFF and CS-MRI PDFF in terms of hepatic steatosis detection [r = 0.701, 95% confidence interval (CI): 0.604–0.798, r = 0.654, 95% CI: 0.544–0.765, P < 0.001, respectively). A weak level correlation was observed between liver biopsy, MRI methods, and vibration-controlled transient elastography attenuation parameters in 42 available donors. Based on receiver operating characteristic (ROC) analysis, MRS-PDFF and CS-MRI PDFF significantly distinguished >5% of histopathologically detected hepatic steatosis with an area under the ROC curve (AUC) of 0.837 ± 0.036 (P < 0.001, 95% CI: 0.766–0.907) and 0.810 ± 0.036 (P < 0.001, 95% CI: 0.739–0.881), respectively. The negative predictive values (NPVs) of MRS-PDFF and CS-MRI PDFF were 88.3% and 81.3%, respectively. In terms of distinguishing between clinically significant hepatic steatosis (≥10% on histopathology), the AUC of MRS-PDFF and CS-MRI were 0.871 ± 0.034 (P < 0.001 95% CI: 0.804–0.937) and 0.855 ± 0.036 (P < 0.001, 95% CI: 0.784–0.925), respectively. The NPVs of MRS-PDFF and CS-MRI were 99% and 92%, respectively. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The methods of MRS-PDFF and CS-MRI PDFF provide a non-invasive and accurate approach for assessing hepatic steatosis in potential living liver donor candidates. These MRI PDFF techniques present a promising clinical advantage in the preoperative evaluation of living liver donors by eliminating the requirement for invasive procedures like liver biopsy. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+resonance+spectroscopy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic resonance spectroscopy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22liver+transplantation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">liver transplantation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22living+liver+donor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">living liver donor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metabolic-associated+steatotic+liver+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metabolic-associated steatotic liver disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22proton+density+fat+fraction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">proton density fat fraction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chemical+shift-based+magnetic+resonance+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chemical shift-based magnetic resonance imaging</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Living+Donors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Living Donors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biopsy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biopsy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Transplantation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Transplantation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Spectroscopy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Spectroscopy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Elasticity+Imaging+Techniques%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Elasticity Imaging Techniques/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROC+Curve%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROC Curve</a></li></ul> <a href="javascript:ShowArticleMeSH(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(25);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> </tbody></table> <div class="search-pager-container"> <div class="dxpLite_MetropolisBlue" id="RootHolder_SearchResultPager" style="margin-top: 20px; margin-bottom: 20px;"> <b class="dxp-lead dxp-button dxp-bi dxp-disabledButton"><img class="dxWeb_pPrevDisabled_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Prev" /></b><b class="dxp-summary" style="margin-left:0px;">Page 1 of 151 </b><b class="dxp-num dxp-current page-number" style="margin-left:0px;">1</b><a class="dxp-num page-number" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">2</a><a class="dxp-num page-number" href="/Search?page=3&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">3</a><a class="dxp-num page-number" href="/Search?page=4&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">4</a><a class="dxp-num page-number" href="/Search?page=5&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">5</a><b class="dxp-ellip" style="margin-left:0px;">…</b><a class="dxp-num page-number" href="/Search?page=150&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">150</a><a class="dxp-num page-number" href="/Search?page=151&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">151</a><a class="dxp-button dxp-bi" onclick="ASPx.PGNav(event);" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;"><img class="dxWeb_pNext_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Next" /></a> </div><b class="dx-clear"></b><script id="dxss_1876454063" type="text/javascript">  </script> </div> </div> <div class="cl"></div> </div> </div> </div> <table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="RootHolder_LeftLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="text-align:Center;vertical-align:Top;"><span id="RootHolder_LeftLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="RootHolder_LeftLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1950550554" type="text/javascript">  </script> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleCitationPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleCitationPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1115091042" type="text/javascript">  </script> <div id="RootHolder_chartPopupControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Fatty Liver/pathology (3753 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Fatty Liver/pathology (3753 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>