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Membranome database - Wikipedia

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class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Online biodatabase of proteins</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">For other uses, see <a href="/wiki/Membranome" title="Membranome">Membranome</a>.</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox vevent" style="width:"><caption class="infobox-title summary">Membranome</caption><tbody><tr><th colspan="2" class="infobox-header" style="background-color: lavender">Content</th></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Description</th><td class="infobox-data">Data about <a href="/wiki/Bitopic_protein" class="mw-redirect" title="Bitopic protein">single-span (bitopic) transmembrane proteins</a> in genomes</td></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Data types<br />captured</th><td class="infobox-data">All bitopic proteins from six model organisms</td></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap"><a href="/wiki/Organism" title="Organism">Organisms</a></th><td class="infobox-data"><a href="/wiki/Homo_sapiens" class="mw-redirect" title="Homo sapiens">Homo sapiens</a>, <a href="/wiki/Arabidopsis_thaliana" title="Arabidopsis thaliana">Arabidopsis thaliana</a>, <a href="/wiki/Dictyostelium_discoideum" title="Dictyostelium discoideum">Dictyostelium discoideum</a>, <a href="/wiki/Saccharomyces_cerevisiae" title="Saccharomyces cerevisiae">Saccharomyces cerevisiae</a>, <a href="/wiki/Escherichia_coli" title="Escherichia coli">Escherichia coli</a>, <a href="/wiki/Methanococcus_jannaschii" class="mw-redirect" title="Methanococcus jannaschii">Methanococcus jannaschii</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: lavender">Contact</th></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap"><a href="/wiki/Research_center" class="mw-redirect" title="Research center">Research center</a></th><td class="infobox-data"><a href="/wiki/University_of_Michigan_College_of_Pharmacy" title="University of Michigan College of Pharmacy">University of Michigan College of Pharmacy</a></td></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Primary citation</th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27510400">27510400</a></td></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Release date</th><td class="infobox-data">2017</td></tr><tr><th colspan="2" class="infobox-header" style="background-color: lavender">Access</th></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Website</th><td class="infobox-data"><a rel="nofollow" class="external free" href="http://membranome.org">http://membranome.org</a></td></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Download URL</th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20180716192828/http://membranome.org:80/download.php">Archived</a> 16 July 2018 at the <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: lavender">Tools</th></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap"><a href="/wiki/Web_application" title="Web application">Web</a></th><td class="infobox-data"><span class="url"><a rel="nofollow" class="external text" href="https://membranome.org/fmap">FMAP</a></span> and <span class="url"><a rel="nofollow" class="external text" href="https://membranome.org/tmdock">TMDOCK</a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: lavender">Miscellaneous</th></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Version</th><td class="infobox-data">3.0</td></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Curation policy</th><td class="infobox-data">Curated</td></tr></tbody></table> <p><b>Membranome database</b> provides structural and functional information about more than 6000 <a href="/wiki/Bitopic_protein" class="mw-redirect" title="Bitopic protein">single-pass (bitopic) transmembrane proteins</a> from <i><a href="/wiki/Homo_sapiens" class="mw-redirect" title="Homo sapiens">Homo sapiens</a></i>, <i><a href="/wiki/Arabidopsis_thaliana" title="Arabidopsis thaliana">Arabidopsis thaliana</a></i>, <i><a href="/wiki/Dictyostelium_discoideum" title="Dictyostelium discoideum">Dictyostelium discoideum</a></i>, <i><a href="/wiki/Saccharomyces_cerevisiae" title="Saccharomyces cerevisiae">Saccharomyces cerevisiae</a></i>, <i><a href="/wiki/Escherichia_coli" title="Escherichia coli">Escherichia coli</a></i> and <i><a href="/wiki/Methanocaldococcus_jannaschii" title="Methanocaldococcus jannaschii">Methanocaldococcus jannaschii</a></i>.<sup id="cite_ref-Membranome-1_1-0" class="reference"><a href="#cite_note-Membranome-1-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Bitopic membrane proteins consist of a single transmembrane alpha-helix connecting water-soluble domains of the protein situated at the opposite sides of a biological membrane. These proteins are frequently involved in the <a href="/wiki/Signal_transduction" title="Signal transduction">signal transduction</a> and communication between cells in <a href="/wiki/Multicellular_organisms" class="mw-redirect" title="Multicellular organisms">multicellular organisms</a>. </p><p>The database provides information about the individual proteins including computationally generated three-dimensional models of their transmembrane <a href="/wiki/Alpha-helices" class="mw-redirect" title="Alpha-helices">alpha-helices</a> spatially arranged in the membrane, <a href="/wiki/Membrane_topology" title="Membrane topology">topology</a>, <a href="/wiki/Protein_localization" class="mw-redirect" title="Protein localization">intracellular localizations</a>, <a href="/wiki/Amino_acid_sequence" class="mw-redirect" title="Amino acid sequence">amino acid sequences</a>, <a href="/wiki/Protein_domain" title="Protein domain">domain architecture</a>, functional annotation and available <a href="/wiki/Protein_structure" title="Protein structure">experimental structures</a> from the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">Protein Data Bank</a>. It also provides a classification of bitopic proteins into 15 functional classes, more than 700 structural superfamilies and 1400 families, along with 3D structures of bitopic protein <a href="/wiki/Protein_complex" title="Protein complex">complexes</a> which are also classified to different families.<sup id="cite_ref-Membranome-1_1-1" class="reference"><a href="#cite_note-Membranome-1-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> The second Membranome version<sup id="cite_ref-Membranome-2_2-0" class="reference"><a href="#cite_note-Membranome-2-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> provides 3D models of more than 2000 parallel homodimers formed by TM α-helices of bitopic proteins from different organisms which were generated using TMDOCK program.<sup id="cite_ref-TMDOCK_3-0" class="reference"><a href="#cite_note-TMDOCK-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> The models of the homodimers were verified through comparison with available experimental data for nearly 600 proteins.<sup id="cite_ref-Verification_4-0" class="reference"><a href="#cite_note-Verification-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> The database includes downloadable coordinate files of transmembrane helices and their homodimers with calculated membrane boundaries. Membranome 3.0 version incorporates models generated by <a href="/wiki/AlphaFold" title="AlphaFold">AlphaFold 2</a>.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> </p><p>The database website provides access to related webservers, FMAP<sup id="cite_ref-Framework_6-0" class="reference"><a href="#cite_note-Framework-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> and TMDOCK which have been developed for modeling individual alpha-helices and their dimeric complexes in membranes. The database and webservers were used in experimental and bioinformatics studies of bitopic membrane proteins<sup id="cite_ref-Pogozheva_7-0" class="reference"><a href="#cite_note-Pogozheva-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Almeida_8-0" class="reference"><a href="#cite_note-Almeida-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Lesovoy_9-0" class="reference"><a href="#cite_note-Lesovoy-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Mineev_10-0" class="reference"><a href="#cite_note-Mineev-10"><span class="cite-bracket">&#91;</span>10<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Membranome_database&amp;action=edit&amp;section=1" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-Membranome-1-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-Membranome-1_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Membranome-1_1-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLomizeLomizeKrolickiPogozheva2017" class="citation journal cs1">Lomize, Andrei L; Lomize, Mikhail A; Krolicki, SR; Pogozheva, Irina D. (2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210604">"Membranome: a database for proteome-wide analysis of single-pass membrane proteins"</a>. <i><a href="/wiki/Nucleic_Acids_Research" title="Nucleic Acids Research">Nucleic Acids Res.</a></i> <b>45</b> (D1): D250–D255. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fnar%2Fgkw712">10.1093/nar/gkw712</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210604">5210604</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27510400">27510400</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Nucleic+Acids+Res.&amp;rft.atitle=Membranome%3A+a+database+for+proteome-wide+analysis+of+single-pass+membrane+proteins.&amp;rft.volume=45&amp;rft.issue=D1&amp;rft.pages=D250-D255&amp;rft.date=2017&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5210604%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F27510400&amp;rft_id=info%3Adoi%2F10.1093%2Fnar%2Fgkw712&amp;rft.aulast=Lomize&amp;rft.aufirst=Andrei+L&amp;rft.au=Lomize%2C+Mikhail+A&amp;rft.au=Krolicki%2C+SR&amp;rft.au=Pogozheva%2C+Irina+D.&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5210604&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AMembranome+database" class="Z3988"></span></span> </li> <li id="cite_note-Membranome-2-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-Membranome-2_2-0">^</a></b></span> <span class="reference-text"><i>Membranome 2.0: database for proteome-wide profiling of bitopic proteins and their dimers</i>, by: Lomize, Andrei L., Hage, Jacob M., Pogozheva, Irina D., <i><a href="/wiki/Bioinformatics_(journal)" title="Bioinformatics (journal)">Bioinformatics</a></i>, volume: 34, issue: 6 pages: 1061-1062.</span> </li> <li id="cite_note-TMDOCK-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-TMDOCK_3-0">^</a></b></span> <span class="reference-text"><i>TMDOCK: An Energy -Based Method for Modeling alpha-Helical Dimers in Membranes</i>, by Lomize, Andrei L. and Pogozheva, Irina D., <a href="/wiki/Journal_of_Molecular_Biology" title="Journal of Molecular Biology">J. Mol. Biol.</a>, Volume: 429 Issue: 3, pages: 390-398</span> </li> <li id="cite_note-Verification-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-Verification_4-0">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://membranome.org/about#verification">Dimer verification page of Membranome</a></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLomizeSchnitzerToddCherepanov2022" class="citation journal cs1">Lomize, A. L.; Schnitzer, K. A.; Todd, S. C.; Cherepanov, S.; Outeiral, C.; Deane, C. M.; Pogozheva, I. D. (2022). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047035">"Membranome 3.0: Database of single-pass membrane proteins with AlphaFold models"</a>. <i><a href="/wiki/Protein_Science" title="Protein Science">Protein Science</a></i>. <b>31</b> (5): e4318. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fpro.4318">10.1002/pro.4318</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047035">9047035</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/35481632">35481632</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Protein+Science&amp;rft.atitle=Membranome+3.0%3A+Database+of+single-pass+membrane+proteins+with+AlphaFold+models&amp;rft.volume=31&amp;rft.issue=5&amp;rft.pages=e4318&amp;rft.date=2022&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9047035%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F35481632&amp;rft_id=info%3Adoi%2F10.1002%2Fpro.4318&amp;rft.aulast=Lomize&amp;rft.aufirst=A.+L.&amp;rft.au=Schnitzer%2C+K.+A.&amp;rft.au=Todd%2C+S.+C.&amp;rft.au=Cherepanov%2C+S.&amp;rft.au=Outeiral%2C+C.&amp;rft.au=Deane%2C+C.+M.&amp;rft.au=Pogozheva%2C+I.+D.&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9047035&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AMembranome+database" class="Z3988"></span></span> </li> <li id="cite_note-Framework-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-Framework_6-0">^</a></b></span> <span class="reference-text"><i>Thermodynamic model of secondary structure for alpha-helical peptides and proteins</i>, by Lomize, AL and Mosberg, HI, <a href="/wiki/Biopolymers_(journal)" title="Biopolymers (journal)">Biopolymers</a>, vol 42, issue: 2, pages: 239-269</span> </li> <li id="cite_note-Pogozheva-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-Pogozheva_7-0">^</a></b></span> <span class="reference-text"><i>Evolution and adaptation of single-pass transmembrane proteins</i>, by: Pogozheva, Irina D. and Lomize, Andrei L., <a href="/wiki/Biochimica_et_Biophysica_Acta" title="Biochimica et Biophysica Acta">Biochimica et. Biophysica Acta Biomembranes</a>, Volume: 1860 Issue: 2 Pages: 364-377</span> </li> <li id="cite_note-Almeida-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-Almeida_8-0">^</a></b></span> <span class="reference-text"><i>Membrane proteins structures: A review on computational modeling tools</i>, by Almeida, Jose G.; Preto, Antonio J., Koukos, Panagiotis I., Bonvin, Alexandre M. J. J., Moreira, Irina S. <a href="/wiki/Biochimica_et_Biophysica_Acta" title="Biochimica et Biophysica Acta">Biochimica et. Biophysica Acta</a>, vol. 1859, issue: 10, pages: 2021-2039</span> </li> <li id="cite_note-Lesovoy-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-Lesovoy_9-0">^</a></b></span> <span class="reference-text"><i>NMR relaxation parameters of methyl groups as a tool to map the interfaces of helix-helix interactions in membrane proteins</i>, by Lesovoy, D. M., Mineev, K. S., Bragin, P. E., Bocharova, O. V., Bocharov, E. V., Arseniev, A. S., <a href="/wiki/Journal_of_Biomolecular_NMR" title="Journal of Biomolecular NMR">J. Biomol. NMR</a>, vol. 69, issue: 3, pages 165-179</span> </li> <li id="cite_note-Mineev-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-Mineev_10-0">^</a></b></span> <span class="reference-text"><i>Spatial structure of TLR4 transmembrane domain in bicelles provides the insight into the receptor activation mechanism</i>, by Mineev, Konstantin S., Goncharuk, Sergey A., Goncharuk, Marina V., Volynsky, Pavel E., Novikova, Ekaterina V., Arseinev, Alexander S., <a href="/wiki/Scientific_Reports" title="Scientific Reports">Scientific Reports</a>, vol. 7, article number: 6864</span> </li> </ol></div></div> <!-- NewPP limit report Parsed by mw‐web.eqiad.main‐5dc468848‐xbx9n Cached time: 20241122183612 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1] CPU time usage: 0.234 seconds Real time usage: 0.325 seconds Preprocessor visited node count: 1032/1000000 Post‐expand include size: 18637/2097152 bytes Template argument size: 2376/2097152 bytes Highest expansion depth: 23/100 Expensive parser function count: 2/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 18023/5000000 bytes Lua time usage: 0.137/10.000 seconds Lua memory usage: 3733649/52428800 bytes Number of Wikibase entities loaded: 0/400 --> <!-- Transclusion expansion time report (%,ms,calls,template) 100.00% 301.556 1 -total 36.89% 111.245 1 Template:Infobox_biodatabase 34.44% 103.870 1 Template:Infobox 28.56% 86.133 1 Template:Reflist 23.76% 71.656 1 Template:Short_description 22.80% 68.766 2 Template:Cite_journal 15.29% 46.096 2 Template:If_empty 13.68% 41.238 2 Template:Pagetype 13.50% 40.713 1 Template:Ifnumber 12.64% 38.121 1 Template:PMID --> <!-- Saved in parser cache with key enwiki:pcache:idhash:57858427-0!canonical and timestamp 20241122183612 and revision id 1241177470. 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