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id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Početak</div> </a> </li> <li id="toc-Aminokiselinska_sekvenca" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Aminokiselinska_sekvenca"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Aminokiselinska sekvenca</span> </div> </a> <ul id="toc-Aminokiselinska_sekvenca-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Funkcija" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Funkcija"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Funkcija</span> </div> </a> <ul id="toc-Funkcija-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Dopunska_literatura" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Dopunska_literatura"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Dopunska literatura</span> </div> </a> <ul id="toc-Dopunska_literatura-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sadržaj" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Uključi/isključi sadržaj" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Uključi/isključi sadržaj</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">LARP1</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Idi na članak na drugom jeziku. Dostupno na 5 jezika" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-5" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">5 jezika</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/LARP1" title="LARP1 – arapski" lang="ar" hreflang="ar" data-title="LARP1" data-language-autonym="العربية" data-language-local-name="arapski" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-arz mw-list-item"><a href="https://arz.wikipedia.org/wiki/LARP1" title="LARP1 – Egyptian Arabic" lang="arz" hreflang="arz" data-title="LARP1" data-language-autonym="مصرى" data-language-local-name="Egyptian Arabic" class="interlanguage-link-target"><span>مصرى</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/LARP1" title="LARP1 – engleski" lang="en" hreflang="en" data-title="LARP1" data-language-autonym="English" data-language-local-name="engleski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/LARP1" title="LARP1 – tatarski" lang="tt" hreflang="tt" data-title="LARP1" data-language-autonym="Татарча / tatarça" data-language-local-name="tatarski" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/LARP1" title="LARP1 – ukrajinski" lang="uk" hreflang="uk" data-title="LARP1" data-language-autonym="Українська" data-language-local-name="ukrajinski" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q18037126#sitelinks-wikipedia" title="Uredi međujezičke linkove" class="wbc-editpage">Uredi veze</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Imenski prostori"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/LARP1" title="Prikaži stranicu sa sadržajem [c]" accesskey="c"><span>Stranica</span></a></li><li id="ca-talk" class="new vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Razgovor:LARP1&action=edit&redlink=1" rel="discussion" class="new" title="Razgovor o sadržaju (stranica ne postoji) [r]" accesskey="r"><span>Razgovor</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Promijeni varijantu jezika" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">bosanski</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Pregledi"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/LARP1"><span>Čitaj</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=LARP1&veaction=edit" title="Uredite ovu stranicu [v]" accesskey="v"><span>Uredi</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=LARP1&action=edit" title="Uredite izvorni kod ove stranice [e]" accesskey="e"><span>Uredi izvor</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=LARP1&action=history" title="Prethodne izmjene ove stranice [h]" accesskey="h"><span>Historija</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Alati" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Alati</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Alati</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">sakrij</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="More options" > <div class="vector-menu-heading"> Radnje </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/LARP1"><span>Čitaj</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=LARP1&veaction=edit" title="Uredite ovu stranicu [v]" accesskey="v"><span>Uredi</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=LARP1&action=edit" title="Uredite izvorni kod ove stranice [e]" accesskey="e"><span>Uredi izvor</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=LARP1&action=history"><span>Historija</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Općenito </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Posebno:%C5%A0ta_vodi_ovamo/LARP1" title="Spisak svih članaka koji su povezani s ovim [j]" accesskey="j"><span>Šta vodi ovamo</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Posebno:Srodne_izmjene/LARP1" rel="nofollow" title="Nedavne izmjene na stranicama koje su povezane sa ovom [k]" accesskey="k"><span>Srodne izmjene</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Wikipedia:Upload" title="Postavi slike i druge medije [u]" accesskey="u"><span>Postavi datoteku</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Posebno:Posebne_stranice" title="Spisak svih posebnih stranica [q]" accesskey="q"><span>Posebne stranice</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=LARP1&oldid=3379581" title="Trajni link ove verzije stranice"><span>Trajni link</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=LARP1&action=info" title="Više informacija o ovoj stranici"><span>Informacije o stranici</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Posebno:Citiraj&page=LARP1&id=3379581&wpFormIdentifier=titleform" title="Informacije kako citirati ovu stranicu"><span>Citiraj ovu stranicu</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Posebno:Skra%C4%87iva%C4%8D_adresa&url=https%3A%2F%2Fbs.wikipedia.org%2Fwiki%2FLARP1"><span>Skraćeni link</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Posebno:QrCode&url=https%3A%2F%2Fbs.wikipedia.org%2Fwiki%2FLARP1"><span>Preuzmi QR kod</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Štampanje / izvoz </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Posebno:Kolekcija&bookcmd=book_creator&referer=LARP1"><span>Napravi knjigu</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Posebno:DownloadAsPdf&page=LARP1&action=show-download-screen"><span>Preuzmi kao PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=LARP1&printable=yes" title="Verzija ove stranice za štampanje [p]" accesskey="p"><span>Za štampanje</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> Na drugim projektima </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q18037126" title="Link na povezane podatke spremišnih stavki [g]" accesskey="g"><span>Stavka na Wikipodacima</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Izgled"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Izgled</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">sakrij</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">S Wikipedije, slobodne enciklopedije</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="bs" dir="ltr"><table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">LARP1</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Dostupne strukture</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Proteinska_banka_podataka" title="Proteinska banka podataka">PDB</a></th><td colspan="2" style="background-color:#eee">Pretraga ortologa: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q6ZQ58%20or%20Q6PKG0%20or%20A0A0B4J210">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q6ZQ58,Q6PKG0,A0A0B4J210">RCSB</a> </span></td></tr><tr><td><table class="mw-collapsible mw-collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">Spisak PDB ID kodova</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4ZC4">4ZC4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5C0V">5C0V</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifikatori</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Nomenklatura_gena" class="mw-redirect" title="Nomenklatura gena">Aliasi</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/29531">LARP1</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Vanjski ID-jevi</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/OMIM" title="OMIM">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/612059">612059</a> <a href="/wiki/Informatika_o_mi%C5%A1jem_genomu" title="Informatika o mišjem genomu">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1890165">1890165</a> <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=9089">9089</a> <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=LARP1">LARP1</a> </span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="mw-collapsible mw-collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Lokacija gena (<a href="/wiki/Ljudski_genom" title="Ljudski genom">čovjek</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/Datoteka:Ideogram_human_chromosome_5.svg" class="mw-file-description" title="Hromosom 5 (čovjek)"><img alt="Hromosom 5 (čovjek)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/300px-Ideogram_human_chromosome_5.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/450px-Ideogram_human_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/600px-Ideogram_human_chromosome_5.svg.png 2x" data-file-width="500" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Hromosom" title="Hromosom">Hrom.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Hromosom_5_(%C4%8Dovjek)" class="mw-redirect" title="Hromosom 5 (čovjek)">Hromosom 5 (čovjek)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/Datoteka:Human_chromosome_5_ideogram.svg" class="mw-file-description" title="Hromosom 5 (čovjek)"><img alt="Hromosom 5 (čovjek)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/300px-Human_chromosome_5_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/450px-Human_chromosome_5_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/600px-Human_chromosome_5_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 245.33061660441px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Datoteka:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomska lokacija za LARP1"><img alt="Genomska lokacija za LARP1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 251.3px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Datoteka:Red_rectangle_2x18.png" class="mw-file-description" title="Genomska lokacija za LARP1"><img alt="Genomska lokacija za LARP1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Lokus_(gen)" title="Lokus (gen)">Bend</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">5q33.2</span></td><th scope="row" style="background-color:#c3fdb8">Početak</th><td style="background-color:#eee"><span class="plainlinks">154,682,986 <a href="/wiki/Bazni_par" title="Bazni par">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Kraj</th><td style="background-color:#eee"><span class="plainlinks">154,817,605 <a href="/wiki/Bazni_par" title="Bazni par">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="mw-collapsible mw-collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Lokacija gena (<a href="/wiki/Laboratorijski_mi%C5%A1" title="Laboratorijski miš">miš</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/Datoteka:Ideogram_house_mouse_chromosome_11.svg" class="mw-file-description" title="Hromosom 11 (miš)"><img alt="Hromosom 11 (miš)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/390px-Ideogram_house_mouse_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/520px-Ideogram_house_mouse_chromosome_11.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Hromosom" title="Hromosom">Hrom.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Hromosom 11 (miš)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/Datoteka:Ideogram_of_house_mouse_chromosome_11.svg" class="mw-file-description" title="Hromosom 11 (miš)"><img alt="Hromosom 11 (miš)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/300px-Ideogram_of_house_mouse_chromosome_11.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/450px-Ideogram_of_house_mouse_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/600px-Ideogram_of_house_mouse_chromosome_11.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 134.1618867732px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Datoteka:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomska lokacija za LARP1"><img alt="Genomska lokacija za LARP1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 140.2px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Datoteka:Red_rectangle_2x18.png" class="mw-file-description" title="Genomska lokacija za LARP1"><img alt="Genomska lokacija za LARP1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Lokus_(gen)" title="Lokus (gen)">Bend</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">11|11 B1.3</span></td><th scope="row" style="background-color:#c3fdb8">Početak</th><td style="background-color:#eee"><span class="plainlinks">57,899,890 <a href="/wiki/Bazni_par" title="Bazni par">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Kraj</th><td style="background-color:#eee"><span class="plainlinks">57,952,860 <a href="/wiki/Bazni_par" title="Bazni par">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="mw-collapsible mw-collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Obrazac <a href="/wiki/Ekspresija_gena" title="Ekspresija gena">RNK ekspresije</a></th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/Datoteka:PBB_GE_LARP1_212193_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/3d/PBB_GE_LARP1_212193_s_at_fs.png/250px-PBB_GE_LARP1_212193_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/3d/PBB_GE_LARP1_212193_s_at_fs.png/375px-PBB_GE_LARP1_212193_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/3d/PBB_GE_LARP1_212193_s_at_fs.png/500px-PBB_GE_LARP1_212193_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/Datoteka:PBB_GE_LARP1_212137_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8b/PBB_GE_LARP1_212137_at_fs.png/250px-PBB_GE_LARP1_212137_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8b/PBB_GE_LARP1_212137_at_fs.png/375px-PBB_GE_LARP1_212137_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8b/PBB_GE_LARP1_212137_at_fs.png/500px-PBB_GE_LARP1_212137_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/Datoteka:PBB_GE_LARP1_210966_x_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a6/PBB_GE_LARP1_210966_x_at_fs.png/250px-PBB_GE_LARP1_210966_x_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a6/PBB_GE_LARP1_210966_x_at_fs.png/375px-PBB_GE_LARP1_210966_x_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a6/PBB_GE_LARP1_210966_x_at_fs.png/500px-PBB_GE_LARP1_210966_x_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/23367/">Više referentnih podataka o ekspresiji</a></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="mw-collapsible mw-collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Ontologija_gena" title="Ontologija gena">Ontologija gena</a></th></tr><tr><th style="background-color:#c3fdb8">Molekularna funkcija</th><td style="background-color:#eee"><span class="plainlinks"><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000339">RNA cap binding</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008494">translation activator activity</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031369">translation initiation factor binding</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515,">GO:0001948, GO:0016582 vezivanje za proteine</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008190">eukaryotic initiation factor 4E binding</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003730">mRNA 3'-UTR binding</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048027">mRNA 5'-UTR binding</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003723">vezivanje sa RNK</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045296">cadherin binding</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000340">RNA 7-methylguanosine cap binding</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043024">ribosomal small subunit binding</a><br /></span></td></tr><tr><th style="background-color:#c3fdb8">Ćelijska komponenta</th><td style="background-color:#eee"><span class="plainlinks"><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">citoplazma</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031931">TORC1 complex</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrana</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005844">polysome</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010494">cytoplasmic stress granule</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042788">polysomal ribosome</a><br /></span></td></tr><tr><th style="background-color:#c3fdb8">Biološki proces</th><td style="background-color:#eee"><span class="plainlinks"><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006413">translational initiation</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016239">positive regulation of macroautophagy</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045070">positive regulation of viral genome replication</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008283">Ćelijska proliferacija</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031929">TOR signaling</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006412">Biosinteza bjelančevina</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045727">positive regulation of translation</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0017148">negative regulation of translation</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038202">TORC1 signaling</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048255">mRNA stabilization</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072752">cellular response to rapamycin</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1990928">response to amino acid starvation</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006417">regulation of translation</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045947">negative regulation of translational initiation</a><br /></span></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Izvori:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Homologija_sekvence#Ortologija" title="Homologija sekvence">Ortolozi</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Vrste</th><td><b>Čovjek</b></td><td><b>Miš</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=23367&rn=1">23367</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=73158&rn=1">73158</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000155506;db=core">ENSG00000155506</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000037331;db=core">ENSMUSG00000037331</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q6PKG0">Q6PKG0</a></p></td></tr></tbody></table></td><td><table style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q6ZQ58">Q6ZQ58</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNK)</th><td><table class="mw-collapsible mw-collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_015315">NM_015315</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_033551">NM_033551</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001367713">NM_001367713</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001367714">NM_001367714</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001367715">NM_001367715</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001367716">NM_001367716</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001367717">NM_001367717</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001367718">NM_001367718</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001367719">NM_001367719</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_028451">NM_028451</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (bjelančevina)</th><td><table class="mw-collapsible mw-collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_056130">NP_056130</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001354642">NP_001354642</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001354643">NP_001354643</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001354644">NP_001354644</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001354645">NP_001354645</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001354646">NP_001354646</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001354647">NP_001354647</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001354648">NP_001354648</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_291029">NP_291029</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_082727">NP_082727</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Lokacija (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr5:154682986-154817605">Chr 5: 154.68 – 154.82 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr11:57899890-57952860">Chr 11: 57.9 – 57.95 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> pretraga</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;font-size:x-small;background-color:#eee"><a href="/wiki/Wikipodaci" title="Wikipodaci">Wikipodaci</a></td></tr><tr><td colspan="4" style="text-align:center;font-size:x-small;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center;font-size:x-small"><a href="https://www.wikidata.org/wiki/Q18037126" class="extiw" title="d:Q18037126">Pogledaj/uredi – čovjek</a></td><td colspan="2" style="background-color:#eee;text-align:center;font-size:x-small"><a href="https://www.wikidata.org/wiki/Q18265852" class="extiw" title="d:Q18265852">Pogledaj/uredi – miš</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>La-srodni protein 1 (LARP1)</b> jest <a href="/wiki/Protein" class="mw-redirect" title="Protein">protein</a> od kDa, koji je kod <a href="/wiki/Ljudi" class="mw-redirect" title="Ljudi">ljudi</a> <a href="/wiki/Kodon" title="Kodon">kodiran</a> <a href="/wiki/Gen" title="Gen">genom</a> <b>LARP1</b> sa <a href="/wiki/Hromosom_5" title="Hromosom 5">hromosoma 5</a>.<sup id="cite_ref-pmid9872452_5-0" class="reference"><a href="#cite_note-pmid9872452-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10878606_6-0" class="reference"><a href="#cite_note-pmid10878606-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_7-0" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> LARP1 je nova sisarska meta na signalnom putu rapamicinskog kompleksa 1 (mTORC1), često hiperaktiviranog sklopa u <a href="/wiki/Karcinom" title="Karcinom">karcinomu</a> koji regulira <a href="/wiki/Rast_%C4%87elija" class="mw-redirect" title="Rast ćelija">rast</a> i <a href="/wiki/%C4%86elijska_proliferacija" title="Ćelijska proliferacija">proliferaciju ćelija</a> prvenstveno regulacijom <a href="/wiki/Sinteza_proteina" class="mw-redirect" title="Sinteza proteina">sinteze proteina</a>.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Aminokiselinska_sekvenca">Aminokiselinska sekvenca</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LARP1&veaction=edit&section=1" title="Uredi odlomak "Aminokiselinska sekvenca"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=LARP1&action=edit&section=1" title="Edit section's source code: Aminokiselinska sekvenca"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Dužina <a href="/wiki/Polipeptid" class="mw-redirect" title="Polipeptid">polipeptidnog</a> lanca je 1.096 <a href="/wiki/Aminokiselina" title="Aminokiselina">aminokiselina</a>, а <a href="/wiki/Molekularna_masa" class="mw-redirect" title="Molekularna masa">molekulska težina</a> 123.510 <a href="/wiki/Dalton_(jedinica)" class="mw-redirect" title="Dalton (jedinica)">Da</a>.<sup id="cite_ref-UniProt_9-0" class="reference"><a href="#cite_note-UniProt-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <style data-mw-deduplicate="TemplateStyles:r3312387">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 25em;"> <p><small> </small></p><small> </small><ul><small><li><b>C</b>: <a href="/wiki/Cistein" title="Cistein">Cistein</a></li> <li><b>D</b>: <a href="/wiki/Asparaginska_kiselina" title="Asparaginska kiselina">Asparaginska kiselina</a></li> <li><b>E</b>: <a href="/wiki/Glutaminska_kiselina" title="Glutaminska kiselina">Glutaminska kiselina</a></li> <li><b>F</b>: <a href="/wiki/Fenilalanin" title="Fenilalanin">Fenilalanin</a></li> <li><b>G</b>: <a href="/wiki/Glicin" title="Glicin">Glicin</a></li> <li><b>H</b>: <a href="/wiki/Histidin" title="Histidin">Histidin</a></li> <li><b>I</b>: <a href="/wiki/Izoleucin" title="Izoleucin">Izoleucin</a></li> <li><b>K</b>: <a href="/wiki/Lizin" class="mw-redirect" title="Lizin">Lizin</a></li> <li><b>L</b>: <a href="/wiki/Leucin" title="Leucin">Leucin</a></li> <li><b>M</b>: <a href="/wiki/Metionin" title="Metionin">Metionin</a></li> <li><b>N</b>: <a href="/wiki/Asparagin" title="Asparagin">Asparagin</a></li> <li><b>P</b>: <a href="/wiki/Prolin" title="Prolin">Prolin</a></li> <li><b>Q</b>: <a href="/wiki/Glutamin" title="Glutamin">Glutamin</a></li> <li><b>R</b>: <a href="/wiki/Arginin" title="Arginin">Arginin</a></li> <li><b>S</b>: <a href="/wiki/Serin" title="Serin">Serin</a></li> <li><b>T</b>: <a href="/wiki/Treonin" title="Treonin">Treonin</a></li> <li><b>V</b>: <a href="/wiki/Valin" class="mw-redirect" title="Valin">Valin</a></li> <li><b>W</b>: <a href="/wiki/Triptofan" title="Triptofan">Triptofan</a></li> </small><li><small><b>Y</b>: <a href="/wiki/Tirozin" title="Tirozin">Tirozin</a></small></li></ul> </div> <table style="font-family:monospace;"> <tbody><tr style="text-align:right;"><th>10</th><th></th><th>20</th><th></th><th>30</th><th></th><th>40</th><th></th><th>50</th></tr> <tr style="background-color: #eee;"><td>MATQVEPLLP</td><td style="background-color: #f9f9f9;"></td><td>GGATLLQAEE</td><td style="background-color: #f9f9f9;"></td><td>HGGLVRKKPP</td><td style="background-color: #f9f9f9;"></td><td>PAPEGKGEPG</td><td style="background-color: #f9f9f9;"></td><td>PNDVRGGEPD</td></tr> <tr style="background-color: #eee;"><td>GSARRPRPPC</td><td style="background-color: #f9f9f9;"></td><td>AKPHKEGTGQ</td><td style="background-color: #f9f9f9;"></td><td>QERESPRPLQ</td><td style="background-color: #f9f9f9;"></td><td>LPGAEGPAIS</td><td style="background-color: #f9f9f9;"></td><td>DGEEGGGEPG</td></tr> <tr style="background-color: #eee;"><td>AGGGAAGAAG</td><td style="background-color: #f9f9f9;"></td><td>AGRRDFVEAP</td><td style="background-color: #f9f9f9;"></td><td>PPKVNPWTKN</td><td style="background-color: #f9f9f9;"></td><td>ALPPVLTTVN</td><td style="background-color: #f9f9f9;"></td><td>GQSPPEHSAP</td></tr> <tr style="background-color: #eee;"><td>AKVVRAAVPK</td><td style="background-color: #f9f9f9;"></td><td>QRKGSKVGDF</td><td style="background-color: #f9f9f9;"></td><td>GDAINWPTPG</td><td style="background-color: #f9f9f9;"></td><td>EIAHKSVQPQ</td><td style="background-color: #f9f9f9;"></td><td>SHKPQPTRKL</td></tr> <tr style="background-color: #eee;"><td>PPKKDMKEQE</td><td style="background-color: #f9f9f9;"></td><td>KGEGSDSKES</td><td style="background-color: #f9f9f9;"></td><td>PKTKSDESGE</td><td style="background-color: #f9f9f9;"></td><td>EKNGDEDCQR</td><td style="background-color: #f9f9f9;"></td><td>GGQKKKGNKH</td></tr> <tr style="background-color: #eee;"><td>KWVPLQIDMK</td><td style="background-color: #f9f9f9;"></td><td>PEVPREKLAS</td><td style="background-color: #f9f9f9;"></td><td>RPTRPPEPRH</td><td style="background-color: #f9f9f9;"></td><td>IPANRGEIKG</td><td style="background-color: #f9f9f9;"></td><td>SESATYVPVA</td></tr> <tr style="background-color: #eee;"><td>PPTPAWQPEI</td><td style="background-color: #f9f9f9;"></td><td>KPEPAWHDQD</td><td style="background-color: #f9f9f9;"></td><td>ETSSVKSDGA</td><td style="background-color: #f9f9f9;"></td><td>GGARASFRGR</td><td style="background-color: #f9f9f9;"></td><td>GRGRGRGRGR</td></tr> <tr style="background-color: #eee;"><td>GRGGTRTHFD</td><td style="background-color: #f9f9f9;"></td><td>YQFGYRKFDG</td><td style="background-color: #f9f9f9;"></td><td>VEGPRTPKYM</td><td style="background-color: #f9f9f9;"></td><td>NNITYYFDNV</td><td style="background-color: #f9f9f9;"></td><td>SSTELYSVDQ</td></tr> <tr style="background-color: #eee;"><td>ELLKDYIKRQ</td><td style="background-color: #f9f9f9;"></td><td>IEYYFSVDNL</td><td style="background-color: #f9f9f9;"></td><td>ERDFFLRRKM</td><td style="background-color: #f9f9f9;"></td><td>DADGFLPITL</td><td style="background-color: #f9f9f9;"></td><td>IASFHRVQAL</td></tr> <tr style="background-color: #eee;"><td>TTDISLIFAA</td><td style="background-color: #f9f9f9;"></td><td>LKDSKVVEIV</td><td style="background-color: #f9f9f9;"></td><td>DEKVRRREEP</td><td style="background-color: #f9f9f9;"></td><td>EKWPLPPIVD</td><td style="background-color: #f9f9f9;"></td><td>YSQTDFSQLL</td></tr> <tr style="background-color: #eee;"><td>NCPEFVPRQH</td><td style="background-color: #f9f9f9;"></td><td>YQKETESAPG</td><td style="background-color: #f9f9f9;"></td><td>SPRAVTPVPT</td><td style="background-color: #f9f9f9;"></td><td>KTEEVSNLKT</td><td style="background-color: #f9f9f9;"></td><td>LPKGLSASLP</td></tr> <tr style="background-color: #eee;"><td>DLDSENWIEV</td><td style="background-color: #f9f9f9;"></td><td>KKRPRPSPAR</td><td style="background-color: #f9f9f9;"></td><td>PKKSEESRFS</td><td style="background-color: #f9f9f9;"></td><td>HLTSLPQQLP</td><td style="background-color: #f9f9f9;"></td><td>SQQLMSKDQD</td></tr> <tr style="background-color: #eee;"><td>EQEELDFLFD</td><td style="background-color: #f9f9f9;"></td><td>EEMEQMDGRK</td><td style="background-color: #f9f9f9;"></td><td>NTFTAWSDEE</td><td style="background-color: #f9f9f9;"></td><td>SDYEIDDRDV</td><td style="background-color: #f9f9f9;"></td><td>NKILIVTQTP</td></tr> <tr style="background-color: #eee;"><td>HYMRRHPGGD</td><td style="background-color: #f9f9f9;"></td><td>RTGNHTSRAK</td><td style="background-color: #f9f9f9;"></td><td>MSAELAKVIN</td><td style="background-color: #f9f9f9;"></td><td>DGLFYYEQDL</td><td style="background-color: #f9f9f9;"></td><td>WAEKFEPEYS</td></tr> <tr style="background-color: #eee;"><td>QIKQEVENFK</td><td style="background-color: #f9f9f9;"></td><td>KVNMISREQF</td><td style="background-color: #f9f9f9;"></td><td>DTLTPEPPVD</td><td style="background-color: #f9f9f9;"></td><td>PNQEVPPGPP</td><td style="background-color: #f9f9f9;"></td><td>RFQQVPTDAL</td></tr> <tr style="background-color: #eee;"><td>ANKLFGAPEP</td><td style="background-color: #f9f9f9;"></td><td>STIARSLPTT</td><td style="background-color: #f9f9f9;"></td><td>VPESPNYRNT</td><td style="background-color: #f9f9f9;"></td><td>RTPRTPRTPQ</td><td style="background-color: #f9f9f9;"></td><td>LKDSSQTSRF</td></tr> <tr style="background-color: #eee;"><td>YPVVKEGRTL</td><td style="background-color: #f9f9f9;"></td><td>DAKMPRKRKT</td><td style="background-color: #f9f9f9;"></td><td>RHSSNPPLES</td><td style="background-color: #f9f9f9;"></td><td>HVGWVMDSRE</td><td style="background-color: #f9f9f9;"></td><td>HRPRTASISS</td></tr> <tr style="background-color: #eee;"><td>SPSEGTPTVG</td><td style="background-color: #f9f9f9;"></td><td>SYGCTPQSLP</td><td style="background-color: #f9f9f9;"></td><td>KFQHPSHELL</td><td style="background-color: #f9f9f9;"></td><td>KENGFTQHVY</td><td style="background-color: #f9f9f9;"></td><td>HKYRRRCLNE</td></tr> <tr style="background-color: #eee;"><td>RKRLGIGQSQ</td><td style="background-color: #f9f9f9;"></td><td>EMNTLFRFWS</td><td style="background-color: #f9f9f9;"></td><td>FFLRDHFNKK</td><td style="background-color: #f9f9f9;"></td><td>MYEEFKQLAL</td><td style="background-color: #f9f9f9;"></td><td>EDAKEGYRYG</td></tr> <tr style="background-color: #eee;"><td>LECLFRYYSY</td><td style="background-color: #f9f9f9;"></td><td>GLEKKFRLDI</td><td style="background-color: #f9f9f9;"></td><td>FKDFQEETVK</td><td style="background-color: #f9f9f9;"></td><td>DYEAGQLYGL</td><td style="background-color: #f9f9f9;"></td><td>EKFWAFLKYS</td></tr> <tr style="background-color: #eee;"><td>KAKNLDIDPK</td><td style="background-color: #f9f9f9;"></td><td>LQEYLGKFRR</td><td style="background-color: #f9f9f9;"></td><td>LEDFRVDPPM</td><td style="background-color: #f9f9f9;"></td><td>GEEGNHKRHS</td><td style="background-color: #f9f9f9;"></td><td>VVAGGGGGEG</td></tr> <tr style="background-color: #eee;"><td>RKRCPSQSSS</td><td style="background-color: #f9f9f9;"></td><td>RPAAMISQPP</td><td style="background-color: #f9f9f9;"></td><td>TPPTGQPVRE</td><td style="background-color: #f9f9f9;"></td><td>DAKWTSQHSN</td><td style="background-color: #f9f9f9;"></td><td>TQTLGK</td></tr> </tbody></table> <div class="mw-heading mw-heading2"><h2 id="Funkcija">Funkcija</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LARP1&veaction=edit&section=2" title="Uredi odlomak "Funkcija"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=LARP1&action=edit&section=2" title="Edit section's source code: Funkcija"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>LARP1 je najveći od sedam članova porodice proteina LARP (ostali su: LARP1B, LARP3 (poznat i kao originalni La ili SSB), LARP4A, LARP4B, LARP6 i LARP7).<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Svi LARP oni, uključujući ljudske LARP, sadrže po dva konzervirana područja. Prva konzervirana regija dijeli <a href="/wiki/Homolog" class="mw-redirect" title="Homolog">homologiju</a> s La proteinima (naziva se La motiv, dok je druga konzervirana regija (nazvana LA-motiv) ograničena na LARP proteine. LARP1 i 1B takođe sadrže konzerviranu "DM15 regiju" unutar svog <a href="/wiki/C-kraj" title="C-kraj">C-kraja</a>.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Ova regija je jedinstvena i pokazalo se da je potrebna za vezanje <a href="/wiki/RNK" class="mw-redirect" title="RNK">RNK</a>. Mišji Larp1 eksprimiran je u dorzalnim korijenima <a href="/wiki/Ganglija" title="Ganglija">ganglija</a> i <a href="/wiki/Ki%C4%8Dmena_mo%C5%BEdina" title="Kičmena moždina">kičmenoj moždini</a>, kao i u organima u razvoju koje karakteriziraju interakcije <a href="/wiki/Epitel" title="Epitel">epitel</a>-<a href="/wiki/Mezenhim" title="Mezenhim">mezenhim</a>.<sup id="cite_ref-pmid10878606_6-1" class="reference"><a href="#cite_note-pmid10878606-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Ljudski LARP1 prisutan je u niskim razinama u normalnim, ne<a href="/wiki/Embrion" class="mw-redirect" title="Embrion">embrionskim</a> ćelijama, ali je visoko izražen u <a href="/wiki/Epitel" title="Epitel">epitelnim</a> <a href="/wiki/Karcinom" title="Karcinom">karcinomima</a> (kao što su na <a href="/wiki/Rak_jajnika" title="Rak jajnika">jajnicima</a>, <a href="/wiki/Rak_debelog_crijeva" title="Rak debelog crijeva">debelom crijevu</a>, <a href="/wiki/Rak_prostate" title="Rak prostate">prostati</a>, <a href="/wiki/Nemalo%C4%87elijski_karcinom_plu%C4%87a" class="mw-redirect" title="Nemaloćelijski karcinom pluća">nemaloćelijski pluća</a>, hepatoćelijski i <a href="/wiki/Rak_grli%C4%87a_maternice" class="mw-redirect" title="Rak grlića maternice">grliću maternice</a>).<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hopkins_2016_14-0" class="reference"><a href="#cite_note-Hopkins_2016-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Neka istraživanja pokazala su da visoka razina proteina LARP1 korelira s lošijom prognozom kod pacijenata s rakom.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p><p>LARP1 se veže i regulira translaciju terminalnih oligopirimidinskih motiva (TOP <a href="/wiki/IRNK" class="mw-redirect" title="IRNK">iRNK</a>) i može direktno stupiti u interakciju s 5' kap iRNK.<sup id="cite_ref-Hong_2017_18-0" class="reference"><a href="#cite_note-Hong_2017-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Lahr_Fonseca_Ciotti_Al-Ashtal_p._19-0" class="reference"><a href="#cite_note-Lahr_Fonseca_Ciotti_Al-Ashtal_p.-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> Također je pokazano da stupa u interakciju s 3' krajem i <a href="/wiki/Kodiraju%C4%87a_regija" title="Kodirajuća regija">kodirajućim regijama</a> (CDS) ostalih gena.<sup id="cite_ref-Hong_2017_18-1" class="reference"><a href="#cite_note-Hong_2017-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> LARP1 protein kolokalizira sa <a href="/wiki/P-tijelo" title="P-tijelo">stresnim granulama i P-tijelima</a>,<sup id="cite_ref-Nykamp_2008_20-0" class="reference"><a href="#cite_note-Nykamp_2008-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> koji funkcioniraju u skladištenju i razgradnji <a href="/wiki/RNK" class="mw-redirect" title="RNK">RNK</a>. Predloženo je da LARP1 funkcionira u <a href="/wiki/P-tijelo" title="P-tijelo">P-tijelima</a>, kako bi smanjio broj konzerviranih iRNK <a href="/w/index.php?title=Ras_(protein)&action=edit&redlink=1" class="new" title="Ras (protein) (stranica ne postoji)">Ras</a>-<a href="/w/index.php?title=MAPK&action=edit&redlink=1" class="new" title="MAPK (stranica ne postoji)">MAPK</a>. Grupa <a href="/wiki/Homolog" class="mw-redirect" title="Homolog">homologa</a> LARP1-a može funkcionirati u kontroli ekspresije ključnih razvojnih regulatora.<sup id="cite_ref-Nykamp_2008_20-1" class="reference"><a href="#cite_note-Nykamp_2008-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p><p>Nekoliko je studija pokazalo da nedostatak LARP1 selektivno utiče na regrutiranje TOP <a href="/wiki/IRNK" class="mw-redirect" title="IRNK">iRNK</a> u <a href="/wiki/Ribosom" title="Ribosom">polisomima</a>. U nekim ćelijamama raka, nedostatak LARP1 smanjuje <a href="/wiki/%C4%86elijska_proliferacija" title="Ćelijska proliferacija">proliferaciju</a> i aktivira <a href="/wiki/Apoptoza" title="Apoptoza">apoptotsku</a> ćelijsku smrt.<sup id="cite_ref-Hopkins_2016_14-1" class="reference"><a href="#cite_note-Hopkins_2016-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Iako je prijavljeno smanjenje količine proteina kodiranih sa TOP iRNK u utišanim ćelijama LARP1, neki vjeruju da to može biti jednostavno objašnjeno smanjenim brojem TOP transkripata iRNK u ćelijama s nedostatkom LARP1. </p> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LARP1&veaction=edit&section=3" title="Uredi odlomak "Reference"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=LARP1&action=edit&section=3" title="Edit section's source code: Reference"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r3312388">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Oncology+Reports&rft.atitle=LARP1+is+regulated+by+the+XIST%2FmiR-374a+axis+and+functions+as+an+oncogene+in+non-small+cell+lung+carcinoma&rft.volume=38&rft.issue=6&rft.pages=3659-3667&rft.date=2017-12&rft_id=info%3Adoi%2F10.3892%2For.2017.6040&rft_id=info%3Apmid%2F29039571&rft.aulast=Xu&rft.aufirst=Z&rft.au=Xu%2C+J&rft.au=Lu%2C+H&rft.au=Lin%2C+B&rft.au=Cai%2C+S&rft.au=Guo%2C+J&rft.au=Zang%2C+F&rft.au=Chen%2C+R&rft_id=%2F%2Fdoi.org%2F10.3892%252For.2017.6040&rfr_id=info%3Asid%2Fbs.wikipedia.org%3ALARP1" class="Z3988"></span></span> </li> <li id="cite_note-Hong_2017-18"><span class="mw-cite-backlink">^ <a href="#cite_ref-Hong_2017_18-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Hong_2017_18-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite id="CITEREFHongFreebergHanKamath2017" class="citation journal cs1">Hong S, Freeberg MA, Han T, Kamath A, Yao Y, Fukuda T, Suzuki T, Kim JK, Inoki K (juni 2017). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC5484620">"LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs"</a>. <i>eLife</i>. <b>6</b>. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.7554%2Felife.25237">10.7554/elife.25237</a>. <a href="/wiki/PMC_(identifikator)" class="mw-redirect" title="PMC (identifikator)">PMC</a> <span class="cs1-lock-free" title="Slobodno dostupno"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC5484620">5484620</a></span>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/28650797">28650797</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=eLife&rft.atitle=LARP1+functions+as+a+molecular+switch+for+mTORC1-mediated+translation+of+an+essential+class+of+mRNAs&rft.volume=6&rft.date=2017-06&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5484620%23id-name%3DPMC&rft_id=info%3Apmid%2F28650797&rft_id=info%3Adoi%2F10.7554%2Felife.25237&rft.aulast=Hong&rft.aufirst=S&rft.au=Freeberg%2C+MA&rft.au=Han%2C+T&rft.au=Kamath%2C+A&rft.au=Yao%2C+Y&rft.au=Fukuda%2C+T&rft.au=Suzuki%2C+T&rft.au=Kim%2C+JK&rft.au=Inoki%2C+K&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5484620&rfr_id=info%3Asid%2Fbs.wikipedia.org%3ALARP1" class="Z3988"></span></span> </li> <li id="cite_note-Lahr_Fonseca_Ciotti_Al-Ashtal_p.-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-Lahr_Fonseca_Ciotti_Al-Ashtal_p._19-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite id="CITEREFLahrFonsecaCiottiAl-Ashtal2017" class="citation journal cs1">Lahr RM, Fonseca BD, Ciotti GE, Al-Ashtal HA, Jia JJ, Niklaus MR, Blagden SP, Alain T, Berman AJ (april 2017). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC5419741">"La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs"</a>. <i>eLife</i>. <b>6</b>. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.7554%2Felife.24146">10.7554/elife.24146</a>. <a href="/wiki/PMC_(identifikator)" class="mw-redirect" title="PMC (identifikator)">PMC</a> <span class="cs1-lock-free" title="Slobodno dostupno"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC5419741">5419741</a></span>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/28379136">28379136</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=eLife&rft.atitle=La-related+protein+1+%28LARP1%29+binds+the+mRNA+cap%2C+blocking+eIF4F+assembly+on+TOP+mRNAs&rft.volume=6&rft.date=2017-04&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5419741%23id-name%3DPMC&rft_id=info%3Apmid%2F28379136&rft_id=info%3Adoi%2F10.7554%2Felife.24146&rft.aulast=Lahr&rft.aufirst=RM&rft.au=Fonseca%2C+BD&rft.au=Ciotti%2C+GE&rft.au=Al-Ashtal%2C+HA&rft.au=Jia%2C+JJ&rft.au=Niklaus%2C+MR&rft.au=Blagden%2C+SP&rft.au=Alain%2C+T&rft.au=Berman%2C+AJ&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5419741&rfr_id=info%3Asid%2Fbs.wikipedia.org%3ALARP1" class="Z3988"></span></span> </li> <li id="cite_note-Nykamp_2008-20"><span class="mw-cite-backlink">^ <a href="#cite_ref-Nykamp_2008_20-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Nykamp_2008_20-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite id="CITEREFNykampLeeKimble2008" class="citation journal cs1">Nykamp K, Lee MH, Kimble J (juli 2008). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC2441978">"C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis"</a>. <i>RNA</i>. <b>14</b> (7): 1378–89. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1261%2Frna.1066008">10.1261/rna.1066008</a>. <a href="/wiki/PMC_(identifikator)" class="mw-redirect" title="PMC (identifikator)">PMC</a> <span class="cs1-lock-free" title="Slobodno dostupno"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC2441978">2441978</a></span>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/18515547">18515547</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=RNA&rft.atitle=C.+elegans+La-related+protein%2C+LARP-1%2C+localizes+to+germline+P+bodies+and+attenuates+Ras-MAPK+signaling+during+oogenesis&rft.volume=14&rft.issue=7&rft.pages=1378-89&rft.date=2008-07&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2441978%23id-name%3DPMC&rft_id=info%3Apmid%2F18515547&rft_id=info%3Adoi%2F10.1261%2Frna.1066008&rft.aulast=Nykamp&rft.aufirst=K&rft.au=Lee%2C+MH&rft.au=Kimble%2C+J&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2441978&rfr_id=info%3Asid%2Fbs.wikipedia.org%3ALARP1" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Dopunska_literatura">Dopunska literatura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LARP1&veaction=edit&section=4" title="Uredi odlomak "Dopunska literatura"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=LARP1&action=edit&section=4" title="Edit section's source code: Dopunska literatura"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r3303351">.mw-parser-output .refbegin{font-size:90%;margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-100{font-size:100%}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite id="CITEREFHorkeReumannSchweizerWill2004" class="citation journal cs1">Horke S, Reumann K, Schweizer M, Will H, Heise T (juni 2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M401017200">"Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA"</a>. <i>The Journal of Biological Chemistry</i>. <b>279</b> (25): 26563–70. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<span class="cs1-lock-free" title="Slobodno dostupno"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M401017200">10.1074/jbc.M401017200</a></span>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/15060081">15060081</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Nuclear+trafficking+of+La+protein+depends+on+a+newly+identified+nucleolar+localization+signal+and+the+ability+to+bind+RNA&rft.volume=279&rft.issue=25&rft.pages=26563-70&rft.date=2004-06&rft_id=info%3Adoi%2F10.1074%2Fjbc.M401017200&rft_id=info%3Apmid%2F15060081&rft.aulast=Horke&rft.aufirst=S&rft.au=Reumann%2C+K&rft.au=Schweizer%2C+M&rft.au=Will%2C+H&rft.au=Heise%2C+T&rft_id=%2F%2Fdoi.org%2F10.1074%252Fjbc.M401017200&rfr_id=info%3Asid%2Fbs.wikipedia.org%3ALARP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite id="CITEREFBeausoleilJedrychowskiSchwartzElias2004" class="citation journal cs1">Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (august 2004). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC514446">"Large-scale characterization of HeLa cell nuclear phosphoproteins"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>101</b> (33): 12130–5. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<span class="cs1-lock-free" title="Slobodno dostupno"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.0404720101">10.1073/pnas.0404720101</a></span>. <a href="/wiki/PMC_(identifikator)" class="mw-redirect" title="PMC (identifikator)">PMC</a> <span class="cs1-lock-free" title="Slobodno dostupno"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC514446">514446</a></span>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/15302935">15302935</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Large-scale+characterization+of+HeLa+cell+nuclear+phosphoproteins&rft.volume=101&rft.issue=33&rft.pages=12130-5&rft.date=2004-08&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC514446%23id-name%3DPMC&rft_id=info%3Apmid%2F15302935&rft_id=info%3Adoi%2F10.1073%2Fpnas.0404720101&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Jedrychowski%2C+M&rft.au=Schwartz%2C+D&rft.au=Elias%2C+JE&rft.au=Vill%C3%A9n%2C+J&rft.au=Li%2C+J&rft.au=Cohn%2C+MA&rft.au=Cantley%2C+LC&rft.au=Gygi%2C+SP&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC514446&rfr_id=info%3Asid%2Fbs.wikipedia.org%3ALARP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite id="CITEREFJinSmithStarkWells2004" class="citation journal cs1">Jin J, Smith FD, Stark C, 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Biology&rft.atitle=Proteomic%2C+functional%2C+and+domain-based+analysis+of+in+vivo+14-3-3+binding+proteins+involved+in+cytoskeletal+regulation+and+cellular+organization&rft.volume=14&rft.issue=16&rft.pages=1436-50&rft.date=2004-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A2371325%23id-name%3DS2CID&rft_id=info%3Apmid%2F15324660&rft_id=info%3Adoi%2F10.1016%2Fj.cub.2004.07.051&rft.aulast=Jin&rft.aufirst=J&rft.au=Smith%2C+FD&rft.au=Stark%2C+C&rft.au=Wells%2C+CD&rft.au=Fawcett%2C+JP&rft.au=Kulkarni%2C+S&rft.au=Metalnikov%2C+P&rft.au=O%27Donnell%2C+P&rft.au=Taylor%2C+P&rft.au=Taylor%2C+L&rft.au=Zougman%2C+A&rft.au=Woodgett%2C+JR&rft.au=Langeberg%2C+LK&rft.au=Scott%2C+JD&rft.au=Pawson%2C+T&rfr_id=info%3Asid%2Fbs.wikipedia.org%3ALARP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite 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href="https://api.semanticscholar.org/CorpusID:14294292">14294292</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=A+probability-based+approach+for+high-throughput+protein+phosphorylation+analysis+and+site+localization&rft.volume=24&rft.issue=10&rft.pages=1285-92&rft.date=2006-10&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A14294292%23id-name%3DS2CID&rft_id=info%3Apmid%2F16964243&rft_id=info%3Adoi%2F10.1038%2Fnbt1240&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Vill%C3%A9n%2C+J&rft.au=Gerber%2C+SA&rft.au=Rush%2C+J&rft.au=Gygi%2C+SP&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_nature-biotechnology_2006-10_24_10%2Fpage%2F1285&rfr_id=info%3Asid%2Fbs.wikipedia.org%3ALARP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite id="CITEREFOlsenBlagoevGnadMacek2006" class="citation journal cs1">Olsen JV, 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