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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105093368/DEVELOPMENT_AND_VALIDATION_OF_RP_HPLC_METHOD_FOR_ESTIMATION_OF_NAFTOPIDIL_AS_API_AND_IN_TABLET_DOSAGE_FORM">DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF NAFTOPIDIL AS API AND IN TABLET DOSAGE FORM</a></div><div class="wp-workCard_item"><span>WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A reversed phase High Performance Liquid Chromatographic method for the estimation of Naftopidil ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A reversed phase High Performance Liquid Chromatographic method for the estimation of Naftopidil has been developed. The drug was separated on ODS column using methanol and water as mobile phase in ratio of 80:20 v/v at flow rate of 0.8 ml/min. Components are detected simultaneously at 280 nm using UV detector. The detection limits for Naftopidil was 0.0327 μg/ml where as the quantitation limits was 0.0991 g/ml. Linearity range was established in range of 2-12 μg/ml for Naftopidil. Recovery of the added Naftopidil standard mixture in tablet solution was found 99.81 ± 0.384 with Relative standard deviation (n=3) of 0.384 %. The proposed method has been applied to the determination of Naftopidil in commercial products. The results obtained by methods were in good agreement of true values. The proposed method is simple, accurate, reproducible and suitable for routine analysis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a62e6be29b6a0d2a70690ad7e607733a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104642126,"asset_id":105093368,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104642126/download_file?st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105093368"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105093368"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105093368; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105093368]").text(description); $(".js-view-count[data-work-id=105093368]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105093368; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105093368']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105093368, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a62e6be29b6a0d2a70690ad7e607733a" } } $('.js-work-strip[data-work-id=105093368]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105093368,"title":"DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF NAFTOPIDIL AS API AND IN TABLET DOSAGE FORM","translated_title":"","metadata":{"doi":"10.20959/wjpps201610-7659","abstract":"A reversed phase High Performance Liquid Chromatographic method for the estimation of Naftopidil has been developed. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="profile--tab_heading_container js-section-heading" data-section="Book Reviews" id="Book Reviews"><h3 class="profile--tab_heading_container">Book Reviews by prashant purohit</h3></div><div class="js-work-strip profile--work_container" data-work-id="105734977"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105734977/RUHS_ReviewArticleGestationalDiabetesMellitus"><img alt="Research paper thumbnail of RUHS ReviewArticleGestationalDiabetesMellitus" class="work-thumbnail" src="https://attachments.academia-assets.com/105120029/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105734977/RUHS_ReviewArticleGestationalDiabetesMellitus">RUHS ReviewArticleGestationalDiabetesMellitus</a></div><div class="wp-workCard_item"><span>RUHS Journal of Health Sciences</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Gestational diabetes mellitus (GDM) is defined as a glucose tolerance disorder that occur...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Gestational  diabetes  mellitus  (GDM)  is  defined  as  a <br />glucose tolerance disorder that occurs or is diagnosed for <br />the  first  time  during  pregnancy  and  is  one  of  the  most <br />common pregnancy complication. It is a well characteri-zed disease affecting a significant population of pregnant <br />women  worldwide.  It  has  been  widely  linked  to  undue <br />weight gain associated with factors such as diet, obesity , <br />family  history ,  and  ethnicity .The  clinical  and  public <br />health  relevance  of  GDM  is  widely  debated  due  to  its <br />increasing  incidence,  the  resulting  negative  economic <br />impact,  and  the  potential  for  severe  GDM-related <br />pregnancy  complications.  Also,  effective  prevention <br />strategies  in  this  area  are  still  lacking  and  controversies <br />exist  regarding  diagnosis  and  management of  this  form  of diabetes.INTRODUCTION<br />Gestational  diabetes  mellitus  (GDM)  is  defined  as  a <br />glucose tolerance disorder that occurs or is diagnosed for <br />the  first  time  during  pregnancy  and  is  one  of  the  most <br />common pregnancy complication. It is a well characteri-zed disease affecting a significant population of pregnant <br />women  worldwide.  It  has  been  widely  linked  to  undue <br />weight gain associated with factors such as diet, obesity , <br />family  history ,  and  ethnicity .<br />This  article  provides  an  overview  of  clinical <br />issues  related  to  GDM,  including  the  challenges  of <br />screening  and  diagnosis,  the  pathophysiology  behind <br />GDM,  the  treatment  and  prevention  of  GDM,  and  the  long <br />and  short  term  consequences  of  gestational  diabetes  for <br />both  mother  and  offspring.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="abbcb693684e3af2a5a1d38edb2d0e90" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105120029,"asset_id":105734977,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105120029/download_file?st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105734977"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105734977"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105734977; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105734977]").text(description); $(".js-view-count[data-work-id=105734977]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105734977; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105734977']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105734977, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "abbcb693684e3af2a5a1d38edb2d0e90" } } $('.js-work-strip[data-work-id=105734977]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105734977,"title":"RUHS ReviewArticleGestationalDiabetesMellitus","translated_title":"","metadata":{"abstract":"Gestational diabetes mellitus (GDM) is defined as a \nglucose tolerance disorder that occurs or is diagnosed for \nthe first time during pregnancy and is one of the most \ncommon pregnancy complication. It is a well characteri-zed disease affecting a significant population of pregnant \nwomen worldwide. It has been widely linked to undue \nweight gain associated with factors such as diet, obesity , \nfamily history , and ethnicity .The clinical and public \nhealth relevance of GDM is widely debated due to its \nincreasing incidence, the resulting negative economic \nimpact, and the potential for severe GDM-related \npregnancy complications. Also, effective prevention \nstrategies in this area are still lacking and controversies \nexist regarding diagnosis and management of this form of diabetes.INTRODUCTION\nGestational diabetes mellitus (GDM) is defined as a \nglucose tolerance disorder that occurs or is diagnosed for \nthe first time during pregnancy and is one of the most \ncommon pregnancy complication. It is a well characteri-zed disease affecting a significant population of pregnant \nwomen worldwide. It has been widely linked to undue \nweight gain associated with factors such as diet, obesity , \nfamily history , and ethnicity .\nThis article provides an overview of clinical \nissues related to GDM, including the challenges of \nscreening and diagnosis, the pathophysiology behind \nGDM, the treatment and prevention of GDM, and the long \nand short term consequences of gestational diabetes for \nboth mother and offspring.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"RUHS Journal of Health Sciences"},"translated_abstract":"Gestational diabetes mellitus (GDM) is defined as a \nglucose tolerance disorder that occurs or is diagnosed for \nthe first time during pregnancy and is one of the most \ncommon pregnancy complication. It is a well characteri-zed disease affecting a significant population of pregnant \nwomen worldwide. It has been widely linked to undue \nweight gain associated with factors such as diet, obesity , \nfamily history , and ethnicity .The clinical and public \nhealth relevance of GDM is widely debated due to its \nincreasing incidence, the resulting negative economic \nimpact, and the potential for severe GDM-related \npregnancy complications. Also, effective prevention \nstrategies in this area are still lacking and controversies \nexist regarding diagnosis and management of this form of diabetes.INTRODUCTION\nGestational diabetes mellitus (GDM) is defined as a \nglucose tolerance disorder that occurs or is diagnosed for \nthe first time during pregnancy and is one of the most \ncommon pregnancy complication. It is a well characteri-zed disease affecting a significant population of pregnant \nwomen worldwide. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105734796"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105734796/LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY"><img alt="Research paper thumbnail of LIPID BASED NANOPARTICLES IN CANCER THERAPY" class="work-thumbnail" src="https://attachments.academia-assets.com/105119892/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105734796/LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY">LIPID BASED NANOPARTICLES IN CANCER THERAPY</a></div><div class="wp-workCard_item"><span>Indo American Journal of Pharmaceutical Research</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Investigators were continuously creating novel nanotechnologies to address unmet requirements th...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Investigators were continuously creating novel nanotechnologies to address unmet <br />requirements throughout the administration of therapeutic medicines & imaging agents for <br />cancer treatment & diagnostics, appropriately. LNPs (Lipid nanoparticles) are legitimate <br />particulates (approx. 100 nm in size) gathered from various lipid as well as other biochemical <br />compounds which overall functionality to resolve biological barriers (bioba rriers), allowing <br />LNPs to selectively collect somewhere outside of disease-target cells again for responsive <br />therapeutics. Most pharmaceutically important compounds were insoluble throughout water <br />solutions, were chemical & physiologically unstable, or have toxicities. Among the most <br />potential drug carrier for bioactive organic compounds is LBNPs (Lipid based nanoparticles) <br />technologies. Its present use in chemotherapy has transformed treatment for cancer by <br />increasing the antitumor effect of a number of chemotherapeutics. Because they may be <br />created using naturally occurring sources, LBNPs have great temporal and thermal stability, <br />maximum load potential, simplicity of preparations, cheap manufacturing costs, & big <br />manufacturing output. Furthermore, combining chemotherapeutic drugs with LNPs reduces <br />active therapeutic dosage and toxicities, lowers treatment resistance, & raises drug <br />concentration in tumour cells while reducing concentrations in normal tissue. LBNPs were <br />widely studied in cancer treatment, both in vitro and in vivo, with encouraging outcomes in <br />certain clinical trials. This study provides an overview of the many types of LBNPs which <br />have been created in latest years and their applications and contributions in different types of <br />cancers.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4d102f805ff65076e42ed53f00173339" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105119892,"asset_id":105734796,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105119892/download_file?st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105734796"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105734796"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105734796; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105734796]").text(description); $(".js-view-count[data-work-id=105734796]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105734796; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105734796']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105734796, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4d102f805ff65076e42ed53f00173339" } } $('.js-work-strip[data-work-id=105734796]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105734796,"title":"LIPID BASED NANOPARTICLES IN CANCER THERAPY","translated_title":"","metadata":{"doi":"10.5281/zenodo.8210582","abstract":"Investigators were continuously creating novel nanotechnologies to address unmet \nrequirements throughout the administration of therapeutic medicines \u0026 imaging agents for \ncancer treatment \u0026 diagnostics, appropriately. LNPs (Lipid nanoparticles) are legitimate \nparticulates (approx. 100 nm in size) gathered from various lipid as well as other biochemical \ncompounds which overall functionality to resolve biological barriers (bioba rriers), allowing \nLNPs to selectively collect somewhere outside of disease-target cells again for responsive \ntherapeutics. Most pharmaceutically important compounds were insoluble throughout water \nsolutions, were chemical \u0026 physiologically unstable, or have toxicities. Among the most \npotential drug carrier for bioactive organic compounds is LBNPs (Lipid based nanoparticles) \ntechnologies. Its present use in chemotherapy has transformed treatment for cancer by \nincreasing the antitumor effect of a number of chemotherapeutics. Because they may be \ncreated using naturally occurring sources, LBNPs have great temporal and thermal stability, \nmaximum load potential, simplicity of preparations, cheap manufacturing costs, \u0026 big \nmanufacturing output. Furthermore, combining chemotherapeutic drugs with LNPs reduces \nactive therapeutic dosage and toxicities, lowers treatment resistance, \u0026 raises drug \nconcentration in tumour cells while reducing concentrations in normal tissue. LBNPs were \nwidely studied in cancer treatment, both in vitro and in vivo, with encouraging outcomes in \ncertain clinical trials. This study provides an overview of the many types of LBNPs which \nhave been created in latest years and their applications and contributions in different types of \ncancers.","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Indo American Journal of Pharmaceutical Research"},"translated_abstract":"Investigators were continuously creating novel nanotechnologies to address unmet \nrequirements throughout the administration of therapeutic medicines \u0026 imaging agents for \ncancer treatment \u0026 diagnostics, appropriately. LNPs (Lipid nanoparticles) are legitimate \nparticulates (approx. 100 nm in size) gathered from various lipid as well as other biochemical \ncompounds which overall functionality to resolve biological barriers (bioba rriers), allowing \nLNPs to selectively collect somewhere outside of disease-target cells again for responsive \ntherapeutics. Most pharmaceutically important compounds were insoluble throughout water \nsolutions, were chemical \u0026 physiologically unstable, or have toxicities. Among the most \npotential drug carrier for bioactive organic compounds is LBNPs (Lipid based nanoparticles) \ntechnologies. Its present use in chemotherapy has transformed treatment for cancer by \nincreasing the antitumor effect of a number of chemotherapeutics. Because they may be \ncreated using naturally occurring sources, LBNPs have great temporal and thermal stability, \nmaximum load potential, simplicity of preparations, cheap manufacturing costs, \u0026 big \nmanufacturing output. Furthermore, combining chemotherapeutic drugs with LNPs reduces \nactive therapeutic dosage and toxicities, lowers treatment resistance, \u0026 raises drug \nconcentration in tumour cells while reducing concentrations in normal tissue. LBNPs were \nwidely studied in cancer treatment, both in vitro and in vivo, with encouraging outcomes in \ncertain clinical trials. This study provides an overview of the many types of LBNPs which \nhave been created in latest years and their applications and contributions in different types of \ncancers.","internal_url":"https://www.academia.edu/105734796/LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY","translated_internal_url":"","created_at":"2023-08-18T22:00:45.610-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":5260164,"coauthors_can_edit":true,"document_type":"book_review","co_author_tags":[],"downloadable_attachments":[{"id":105119892,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105119892/thumbnails/1.jpg","file_name":"LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY.pdf","download_url":"https://www.academia.edu/attachments/105119892/download_file?st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"LIPID_BASED_NANOPARTICLES_IN_CANCER_THER.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105119892/LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY-libre.pdf?1692429264=\u0026response-content-disposition=attachment%3B+filename%3DLIPID_BASED_NANOPARTICLES_IN_CANCER_THER.pdf\u0026Expires=1732460272\u0026Signature=aNrpWXHgU3LdIcv0cEv37uCFexs-EVqhTuSBzE1MATPdDW18MjhopZbjIR2Gihytf-wEDQrV4D0cU2anmJO3EWIfCs0dqllT9WhhhMDkfJxF8TK1y1Q2jLLTkrGjPWyLUDW1hJ26c01mDzm3LtHVin97qj3YY0gverAsAKB2Lwt5mWkg~Os5v6WCrDe50u94bzm8720xjJ0C-54jqSEnrBm9X0Q4fHWelxcEDBzUlaA8Lpu97uze8gkM~Y-gPOtbe0psXOOT96SAcxBE075gO4HPxMOUmZISLwtdYj4A-Wzhf3Jq4bkpdCV~KdBaZlN8KkxB4wtBZA3UeffLHULkgA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":5260164,"first_name":"prashant","middle_initials":null,"last_name":"purohit","page_name":"prashantpurohit","domain_name":"ruhsraj","created_at":"2013-08-24T21:14:06.606-07:00","display_name":"prashant purohit","url":"https://ruhsraj.academia.edu/prashantpurohit"},"attachments":[{"id":105119892,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105119892/thumbnails/1.jpg","file_name":"LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY.pdf","download_url":"https://www.academia.edu/attachments/105119892/download_file?st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"LIPID_BASED_NANOPARTICLES_IN_CANCER_THER.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105119892/LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY-libre.pdf?1692429264=\u0026response-content-disposition=attachment%3B+filename%3DLIPID_BASED_NANOPARTICLES_IN_CANCER_THER.pdf\u0026Expires=1732460272\u0026Signature=aNrpWXHgU3LdIcv0cEv37uCFexs-EVqhTuSBzE1MATPdDW18MjhopZbjIR2Gihytf-wEDQrV4D0cU2anmJO3EWIfCs0dqllT9WhhhMDkfJxF8TK1y1Q2jLLTkrGjPWyLUDW1hJ26c01mDzm3LtHVin97qj3YY0gverAsAKB2Lwt5mWkg~Os5v6WCrDe50u94bzm8720xjJ0C-54jqSEnrBm9X0Q4fHWelxcEDBzUlaA8Lpu97uze8gkM~Y-gPOtbe0psXOOT96SAcxBE075gO4HPxMOUmZISLwtdYj4A-Wzhf3Jq4bkpdCV~KdBaZlN8KkxB4wtBZA3UeffLHULkgA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="18364622" id="papers"><div class="js-work-strip profile--work_container" data-work-id="105093368"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105093368/DEVELOPMENT_AND_VALIDATION_OF_RP_HPLC_METHOD_FOR_ESTIMATION_OF_NAFTOPIDIL_AS_API_AND_IN_TABLET_DOSAGE_FORM"><img alt="Research paper thumbnail of DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF NAFTOPIDIL AS API AND IN TABLET DOSAGE FORM" class="work-thumbnail" src="https://attachments.academia-assets.com/104642126/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105093368/DEVELOPMENT_AND_VALIDATION_OF_RP_HPLC_METHOD_FOR_ESTIMATION_OF_NAFTOPIDIL_AS_API_AND_IN_TABLET_DOSAGE_FORM">DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF NAFTOPIDIL AS API AND IN TABLET DOSAGE FORM</a></div><div class="wp-workCard_item"><span>WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A reversed phase High Performance Liquid Chromatographic method for the estimation of Naftopidil ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A reversed phase High Performance Liquid Chromatographic method for the estimation of Naftopidil has been developed. The drug was separated on ODS column using methanol and water as mobile phase in ratio of 80:20 v/v at flow rate of 0.8 ml/min. Components are detected simultaneously at 280 nm using UV detector. The detection limits for Naftopidil was 0.0327 μg/ml where as the quantitation limits was 0.0991 g/ml. Linearity range was established in range of 2-12 μg/ml for Naftopidil. Recovery of the added Naftopidil standard mixture in tablet solution was found 99.81 ± 0.384 with Relative standard deviation (n=3) of 0.384 %. The proposed method has been applied to the determination of Naftopidil in commercial products. The results obtained by methods were in good agreement of true values. The proposed method is simple, accurate, reproducible and suitable for routine analysis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a62e6be29b6a0d2a70690ad7e607733a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104642126,"asset_id":105093368,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104642126/download_file?st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105093368"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105093368"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105093368; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105093368]").text(description); $(".js-view-count[data-work-id=105093368]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105093368; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105093368']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105093368, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a62e6be29b6a0d2a70690ad7e607733a" } } $('.js-work-strip[data-work-id=105093368]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105093368,"title":"DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF NAFTOPIDIL AS API AND IN TABLET DOSAGE FORM","translated_title":"","metadata":{"doi":"10.20959/wjpps201610-7659","abstract":"A reversed phase High Performance Liquid Chromatographic method for the estimation of Naftopidil has been developed. The drug was separated on ODS column using methanol and water as mobile phase in ratio of 80:20 v/v at flow rate of 0.8 ml/min. Components are detected simultaneously at 280 nm using UV detector. The detection limits for Naftopidil was 0.0327 μg/ml where as the quantitation limits was 0.0991 g/ml. Linearity range was established in range of 2-12 μg/ml for Naftopidil. Recovery of the added Naftopidil standard mixture in tablet solution was found 99.81 ± 0.384 with Relative standard deviation (n=3) of 0.384 %. The proposed method has been applied to the determination of Naftopidil in commercial products. The results obtained by methods were in good agreement of true values. The proposed method is simple, accurate, reproducible and suitable for routine analysis.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES"},"translated_abstract":"A reversed phase High Performance Liquid Chromatographic method for the estimation of Naftopidil has been developed. The drug was separated on ODS column using methanol and water as mobile phase in ratio of 80:20 v/v at flow rate of 0.8 ml/min. Components are detected simultaneously at 280 nm using UV detector. The detection limits for Naftopidil was 0.0327 μg/ml where as the quantitation limits was 0.0991 g/ml. Linearity range was established in range of 2-12 μg/ml for Naftopidil. Recovery of the added Naftopidil standard mixture in tablet solution was found 99.81 ± 0.384 with Relative standard deviation (n=3) of 0.384 %. The proposed method has been applied to the determination of Naftopidil in commercial products. The results obtained by methods were in good agreement of true values. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="18446644" id="bookreviews"><div class="js-work-strip profile--work_container" data-work-id="105734977"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105734977/RUHS_ReviewArticleGestationalDiabetesMellitus"><img alt="Research paper thumbnail of RUHS ReviewArticleGestationalDiabetesMellitus" class="work-thumbnail" src="https://attachments.academia-assets.com/105120029/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105734977/RUHS_ReviewArticleGestationalDiabetesMellitus">RUHS ReviewArticleGestationalDiabetesMellitus</a></div><div class="wp-workCard_item"><span>RUHS Journal of Health Sciences</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Gestational diabetes mellitus (GDM) is defined as a glucose tolerance disorder that occur...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Gestational  diabetes  mellitus  (GDM)  is  defined  as  a <br />glucose tolerance disorder that occurs or is diagnosed for <br />the  first  time  during  pregnancy  and  is  one  of  the  most <br />common pregnancy complication. It is a well characteri-zed disease affecting a significant population of pregnant <br />women  worldwide.  It  has  been  widely  linked  to  undue <br />weight gain associated with factors such as diet, obesity , <br />family  history ,  and  ethnicity .The  clinical  and  public <br />health  relevance  of  GDM  is  widely  debated  due  to  its <br />increasing  incidence,  the  resulting  negative  economic <br />impact,  and  the  potential  for  severe  GDM-related <br />pregnancy  complications.  Also,  effective  prevention <br />strategies  in  this  area  are  still  lacking  and  controversies <br />exist  regarding  diagnosis  and  management of  this  form  of diabetes.INTRODUCTION<br />Gestational  diabetes  mellitus  (GDM)  is  defined  as  a <br />glucose tolerance disorder that occurs or is diagnosed for <br />the  first  time  during  pregnancy  and  is  one  of  the  most <br />common pregnancy complication. It is a well characteri-zed disease affecting a significant population of pregnant <br />women  worldwide.  It  has  been  widely  linked  to  undue <br />weight gain associated with factors such as diet, obesity , <br />family  history ,  and  ethnicity .<br />This  article  provides  an  overview  of  clinical <br />issues  related  to  GDM,  including  the  challenges  of <br />screening  and  diagnosis,  the  pathophysiology  behind <br />GDM,  the  treatment  and  prevention  of  GDM,  and  the  long <br />and  short  term  consequences  of  gestational  diabetes  for <br />both  mother  and  offspring.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="abbcb693684e3af2a5a1d38edb2d0e90" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105120029,"asset_id":105734977,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105120029/download_file?st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105734977"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105734977"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105734977; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105734977]").text(description); $(".js-view-count[data-work-id=105734977]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105734977; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105734977']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105734977, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "abbcb693684e3af2a5a1d38edb2d0e90" } } $('.js-work-strip[data-work-id=105734977]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105734977,"title":"RUHS ReviewArticleGestationalDiabetesMellitus","translated_title":"","metadata":{"abstract":"Gestational diabetes mellitus (GDM) is defined as a \nglucose tolerance disorder that occurs or is diagnosed for \nthe first time during pregnancy and is one of the most \ncommon pregnancy complication. 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It has been widely linked to undue \nweight gain associated with factors such as diet, obesity , \nfamily history , and ethnicity .\nThis article provides an overview of clinical \nissues related to GDM, including the challenges of \nscreening and diagnosis, the pathophysiology behind \nGDM, the treatment and prevention of GDM, and the long \nand short term consequences of gestational diabetes for \nboth mother and offspring.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"RUHS Journal of Health Sciences"},"translated_abstract":"Gestational diabetes mellitus (GDM) is defined as a \nglucose tolerance disorder that occurs or is diagnosed for \nthe first time during pregnancy and is one of the most \ncommon pregnancy complication. It is a well characteri-zed disease affecting a significant population of pregnant \nwomen worldwide. It has been widely linked to undue \nweight gain associated with factors such as diet, obesity , \nfamily history , and ethnicity .The clinical and public \nhealth relevance of GDM is widely debated due to its \nincreasing incidence, the resulting negative economic \nimpact, and the potential for severe GDM-related \npregnancy complications. Also, effective prevention \nstrategies in this area are still lacking and controversies \nexist regarding diagnosis and management of this form of diabetes.INTRODUCTION\nGestational diabetes mellitus (GDM) is defined as a \nglucose tolerance disorder that occurs or is diagnosed for \nthe first time during pregnancy and is one of the most \ncommon pregnancy complication. It is a well characteri-zed disease affecting a significant population of pregnant \nwomen worldwide. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105734796"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105734796/LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY"><img alt="Research paper thumbnail of LIPID BASED NANOPARTICLES IN CANCER THERAPY" class="work-thumbnail" src="https://attachments.academia-assets.com/105119892/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105734796/LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY">LIPID BASED NANOPARTICLES IN CANCER THERAPY</a></div><div class="wp-workCard_item"><span>Indo American Journal of Pharmaceutical Research</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Investigators were continuously creating novel nanotechnologies to address unmet requirements th...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Investigators were continuously creating novel nanotechnologies to address unmet <br />requirements throughout the administration of therapeutic medicines & imaging agents for <br />cancer treatment & diagnostics, appropriately. LNPs (Lipid nanoparticles) are legitimate <br />particulates (approx. 100 nm in size) gathered from various lipid as well as other biochemical <br />compounds which overall functionality to resolve biological barriers (bioba rriers), allowing <br />LNPs to selectively collect somewhere outside of disease-target cells again for responsive <br />therapeutics. Most pharmaceutically important compounds were insoluble throughout water <br />solutions, were chemical & physiologically unstable, or have toxicities. Among the most <br />potential drug carrier for bioactive organic compounds is LBNPs (Lipid based nanoparticles) <br />technologies. Its present use in chemotherapy has transformed treatment for cancer by <br />increasing the antitumor effect of a number of chemotherapeutics. Because they may be <br />created using naturally occurring sources, LBNPs have great temporal and thermal stability, <br />maximum load potential, simplicity of preparations, cheap manufacturing costs, & big <br />manufacturing output. Furthermore, combining chemotherapeutic drugs with LNPs reduces <br />active therapeutic dosage and toxicities, lowers treatment resistance, & raises drug <br />concentration in tumour cells while reducing concentrations in normal tissue. LBNPs were <br />widely studied in cancer treatment, both in vitro and in vivo, with encouraging outcomes in <br />certain clinical trials. This study provides an overview of the many types of LBNPs which <br />have been created in latest years and their applications and contributions in different types of <br />cancers.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4d102f805ff65076e42ed53f00173339" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105119892,"asset_id":105734796,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105119892/download_file?st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105734796"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105734796"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105734796; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105734796]").text(description); $(".js-view-count[data-work-id=105734796]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105734796; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105734796']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105734796, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4d102f805ff65076e42ed53f00173339" } } $('.js-work-strip[data-work-id=105734796]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105734796,"title":"LIPID BASED NANOPARTICLES IN CANCER THERAPY","translated_title":"","metadata":{"doi":"10.5281/zenodo.8210582","abstract":"Investigators were continuously creating novel nanotechnologies to address unmet \nrequirements throughout the administration of therapeutic medicines \u0026 imaging agents for \ncancer treatment \u0026 diagnostics, appropriately. LNPs (Lipid nanoparticles) are legitimate \nparticulates (approx. 100 nm in size) gathered from various lipid as well as other biochemical \ncompounds which overall functionality to resolve biological barriers (bioba rriers), allowing \nLNPs to selectively collect somewhere outside of disease-target cells again for responsive \ntherapeutics. Most pharmaceutically important compounds were insoluble throughout water \nsolutions, were chemical \u0026 physiologically unstable, or have toxicities. Among the most \npotential drug carrier for bioactive organic compounds is LBNPs (Lipid based nanoparticles) \ntechnologies. Its present use in chemotherapy has transformed treatment for cancer by \nincreasing the antitumor effect of a number of chemotherapeutics. Because they may be \ncreated using naturally occurring sources, LBNPs have great temporal and thermal stability, \nmaximum load potential, simplicity of preparations, cheap manufacturing costs, \u0026 big \nmanufacturing output. Furthermore, combining chemotherapeutic drugs with LNPs reduces \nactive therapeutic dosage and toxicities, lowers treatment resistance, \u0026 raises drug \nconcentration in tumour cells while reducing concentrations in normal tissue. LBNPs were \nwidely studied in cancer treatment, both in vitro and in vivo, with encouraging outcomes in \ncertain clinical trials. This study provides an overview of the many types of LBNPs which \nhave been created in latest years and their applications and contributions in different types of \ncancers.","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Indo American Journal of Pharmaceutical Research"},"translated_abstract":"Investigators were continuously creating novel nanotechnologies to address unmet \nrequirements throughout the administration of therapeutic medicines \u0026 imaging agents for \ncancer treatment \u0026 diagnostics, appropriately. LNPs (Lipid nanoparticles) are legitimate \nparticulates (approx. 100 nm in size) gathered from various lipid as well as other biochemical \ncompounds which overall functionality to resolve biological barriers (bioba rriers), allowing \nLNPs to selectively collect somewhere outside of disease-target cells again for responsive \ntherapeutics. Most pharmaceutically important compounds were insoluble throughout water \nsolutions, were chemical \u0026 physiologically unstable, or have toxicities. Among the most \npotential drug carrier for bioactive organic compounds is LBNPs (Lipid based nanoparticles) \ntechnologies. Its present use in chemotherapy has transformed treatment for cancer by \nincreasing the antitumor effect of a number of chemotherapeutics. Because they may be \ncreated using naturally occurring sources, LBNPs have great temporal and thermal stability, \nmaximum load potential, simplicity of preparations, cheap manufacturing costs, \u0026 big \nmanufacturing output. Furthermore, combining chemotherapeutic drugs with LNPs reduces \nactive therapeutic dosage and toxicities, lowers treatment resistance, \u0026 raises drug \nconcentration in tumour cells while reducing concentrations in normal tissue. LBNPs were \nwidely studied in cancer treatment, both in vitro and in vivo, with encouraging outcomes in \ncertain clinical trials. This study provides an overview of the many types of LBNPs which \nhave been created in latest years and their applications and contributions in different types of \ncancers.","internal_url":"https://www.academia.edu/105734796/LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY","translated_internal_url":"","created_at":"2023-08-18T22:00:45.610-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":5260164,"coauthors_can_edit":true,"document_type":"book_review","co_author_tags":[],"downloadable_attachments":[{"id":105119892,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105119892/thumbnails/1.jpg","file_name":"LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY.pdf","download_url":"https://www.academia.edu/attachments/105119892/download_file?st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"LIPID_BASED_NANOPARTICLES_IN_CANCER_THER.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105119892/LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY-libre.pdf?1692429264=\u0026response-content-disposition=attachment%3B+filename%3DLIPID_BASED_NANOPARTICLES_IN_CANCER_THER.pdf\u0026Expires=1732460272\u0026Signature=aNrpWXHgU3LdIcv0cEv37uCFexs-EVqhTuSBzE1MATPdDW18MjhopZbjIR2Gihytf-wEDQrV4D0cU2anmJO3EWIfCs0dqllT9WhhhMDkfJxF8TK1y1Q2jLLTkrGjPWyLUDW1hJ26c01mDzm3LtHVin97qj3YY0gverAsAKB2Lwt5mWkg~Os5v6WCrDe50u94bzm8720xjJ0C-54jqSEnrBm9X0Q4fHWelxcEDBzUlaA8Lpu97uze8gkM~Y-gPOtbe0psXOOT96SAcxBE075gO4HPxMOUmZISLwtdYj4A-Wzhf3Jq4bkpdCV~KdBaZlN8KkxB4wtBZA3UeffLHULkgA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":5260164,"first_name":"prashant","middle_initials":null,"last_name":"purohit","page_name":"prashantpurohit","domain_name":"ruhsraj","created_at":"2013-08-24T21:14:06.606-07:00","display_name":"prashant purohit","url":"https://ruhsraj.academia.edu/prashantpurohit"},"attachments":[{"id":105119892,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105119892/thumbnails/1.jpg","file_name":"LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY.pdf","download_url":"https://www.academia.edu/attachments/105119892/download_file?st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&st=MTczMjQ1NjY3Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"LIPID_BASED_NANOPARTICLES_IN_CANCER_THER.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105119892/LIPID_BASED_NANOPARTICLES_IN_CANCER_THERAPY-libre.pdf?1692429264=\u0026response-content-disposition=attachment%3B+filename%3DLIPID_BASED_NANOPARTICLES_IN_CANCER_THER.pdf\u0026Expires=1732460272\u0026Signature=aNrpWXHgU3LdIcv0cEv37uCFexs-EVqhTuSBzE1MATPdDW18MjhopZbjIR2Gihytf-wEDQrV4D0cU2anmJO3EWIfCs0dqllT9WhhhMDkfJxF8TK1y1Q2jLLTkrGjPWyLUDW1hJ26c01mDzm3LtHVin97qj3YY0gverAsAKB2Lwt5mWkg~Os5v6WCrDe50u94bzm8720xjJ0C-54jqSEnrBm9X0Q4fHWelxcEDBzUlaA8Lpu97uze8gkM~Y-gPOtbe0psXOOT96SAcxBE075gO4HPxMOUmZISLwtdYj4A-Wzhf3Jq4bkpdCV~KdBaZlN8KkxB4wtBZA3UeffLHULkgA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"}],"urls":[]}, dispatcherData: dispatcherData }); 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