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oncology to discuss the newest developments in molecular radiation biology/oncology. This year from June 22 to 24, 2013, during the 13th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology organized in association with ESTRO, almost 170 basic and clinical scientists from 19 different countries worldwide discussed the cutting edge research relevant to the four topics signaling cascades and survival mechanism, DNA damage response, biomarkers and targeting strategies, as well as tumor and normal tissue microenvironment. As keynote speakers internationally leading scientists introduced the various topics by giving overview lectures with respect to basic research as well as translational and clinical aspects. These keynote presentations set the stage for intensive discussions of the posters and proffered paper presentations. As in previous editions of this meeting series all presentations were of high scientific quality. In the following some of the research aspects presented in the four topics are highlighted.","publication_date":"2013,,","publication_name":"Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology","grobid_abstract_attachment_id":"43195113"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Molecular radiation biology/oncology at its best: cutting edge research presented at the 13th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [34582346]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 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href="https://www.academia.edu/114769894/Radiation_biology_and_oncology_in_the_genomic_era">Radiation biology and oncology in the genomic era</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="135690715" href="https://independent.academia.edu/YuhchyauChen">Yuhchyau Chen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The British journal of radiology, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Radiobiology research is building the foundation for applying genomics in precision radiation oncology. Advances in high-throughput approaches will underpin increased understanding of radiosensitivity and the development of future predictive assays for clinical application. There is an established contribution of genetics as a risk factor for radiotherapy side effects. An individual&#39;s radiosensitivity is an inherited polygenic trait with an architecture that includes rare mutations in a few genes that confer large effects and common variants in many genes with small effects. Current thinking is that some will be tissue specific, and future tests will be tailored to the normal tissues at risk. The relationship between normal and tumor cell radiosensitivity is poorly understood. Data are emerging suggesting interplay between germline genetic variation and epigenetic modification with growing evidence that changes in DNA methylation regulate the radiosensitivity of cancer cells and...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Radiation biology and oncology in the genomic era","attachmentId":111375417,"attachmentType":"pdf","work_url":"https://www.academia.edu/114769894/Radiation_biology_and_oncology_in_the_genomic_era","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/114769894/Radiation_biology_and_oncology_in_the_genomic_era"><span 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