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(PDF) Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications | William Benedict - Academia.edu
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Analysis of the protein products of these genes by molecular and" /> <title>(PDF) Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications | William Benedict - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/25730856/Expression_of_p16_Rb_and_cyclin_D1_gene_products_in_oral_and_laryngeal_squamous_carcinoma_biological_and_clinical_implications" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732418836000); window.Aedu.timeDifference = new Date().getTime() - 1732418836000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Cyclin D1, p16, and Rb genes play a critical role in the regulation of the G1-S transition of the cell cycle and are frequently altered in several neoplastic entities. Analysis of the protein products of these genes by molecular and immunohistochemical methods provides information on their functional status and allows for the phenotypic evaluation of tumor cells. We performed Western blotting and immunohistochemical analysis on tissues from 35 primary oral and laryngeal squamous carcinoma specimens with previous molecular analysis of the p16 gene and correlated the results with relevant clinicopathologic factors. Our study shows significant concordance between Western blotting and immunostaining results for cyclin D1 (P = .01), p16 proteins (P = .01), and Rb (P = .04). Heterogeneous staining of tumor cells and the positivity of non-neoplastic host elements for Rb by immunohistochemistry contributed to the discrepancy noted in some tumors by Western blotting. Significant reciprocal r...","author":[{"@context":"https://schema.org","@type":"Person","name":"William Benedict"}],"contributor":[],"dateCreated":"2016-05-30","dateModified":"2016-05-30","datePublished":"1999-01-01","headline":"Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications","inLanguage":"en","keywords":["Cell Cycle","Immunohistochemistry","Western blotting","Humans","Mutation","Female","Male","DNA methylation","Clinical Sciences","Aged","Middle Aged","Oral Squamous Cell Carcinoma (OSCC)","Mouth Neoplasms","Adult","Western blot","Human Pathology","Functional Status","retinoblastoma protein (RB1)."],"locationCreated":null,"publication":"Human pathology","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/25730856/Expression_of_p16_Rb_and_cyclin_D1_gene_products_in_oral_and_laryngeal_squamous_carcinoma_biological_and_clinical_implications","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-352e32ba4e89304dc0b4fa5b3952eef2198174c54cdb79066bc62e91c68a1a91.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" 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[{"id":46081491,"identifier":"Attachment_46081491","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":25730856,"created_at":"2016-05-30T16:01:15.993-07:00","from_world_paper_id":153661588,"updated_at":"2022-06-22T22:19:11.988-07:00","_data":{"abstract":"Cyclin D1, p16, and Rb genes play a critical role in the regulation of the G1-S transition of the cell cycle and are frequently altered in several neoplastic entities. Analysis of the protein products of these genes by molecular and immunohistochemical methods provides information on their functional status and allows for the phenotypic evaluation of tumor cells. We performed Western blotting and immunohistochemical analysis on tissues from 35 primary oral and laryngeal squamous carcinoma specimens with previous molecular analysis of the p16 gene and correlated the results with relevant clinicopathologic factors. Our study shows significant concordance between Western blotting and immunostaining results for cyclin D1 (P = .01), p16 proteins (P = .01), and Rb (P = .04). Heterogeneous staining of tumor cells and the positivity of non-neoplastic host elements for Rb by immunohistochemistry contributed to the discrepancy noted in some tumors by Western blotting. Significant reciprocal r...","publication_date":"1999,,","publication_name":"Human pathology"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [49443737]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":46081491,"attachmentType":"pdf"}"><img alt="First page of “Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/46081491/mini_magick20190210-22424-16cmfss.png?1549835398" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="49443737" href="https://independent.academia.edu/WilliamBenedict"><img alt="Profile image of William Benedict" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />William Benedict</a></div><p class="ds-work-card--detail ds2-5-body-sm">1999, Human pathology</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Cyclin D1, p16, and Rb genes play a critical role in the regulation of the G1-S transition of the cell cycle and are frequently altered in several neoplastic entities. Analysis of the protein products of these genes by molecular and immunohistochemical methods provides information on their functional status and allows for the phenotypic evaluation of tumor cells. We performed Western blotting and immunohistochemical analysis on tissues from 35 primary oral and laryngeal squamous carcinoma specimens with previous molecular analysis of the p16 gene and correlated the results with relevant clinicopathologic factors. Our study shows significant concordance between Western blotting and immunostaining results for cyclin D1 (P = .01), p16 proteins (P = .01), and Rb (P = .04). Heterogeneous staining of tumor cells and the positivity of non-neoplastic host elements for Rb by immunohistochemistry contributed to the discrepancy noted in some tumors by Western blotting. Significant reciprocal r...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":46081491,"attachmentType":"pdf","workUrl":"https://www.academia.edu/25730856/Expression_of_p16_Rb_and_cyclin_D1_gene_products_in_oral_and_laryngeal_squamous_carcinoma_biological_and_clinical_implications"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":46081491,"attachmentType":"pdf","workUrl":"https://www.academia.edu/25730856/Expression_of_p16_Rb_and_cyclin_D1_gene_products_in_oral_and_laryngeal_squamous_carcinoma_biological_and_clinical_implications"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="46081491" data-landing_url="https://www.academia.edu/25730856/Expression_of_p16_Rb_and_cyclin_D1_gene_products_in_oral_and_laryngeal_squamous_carcinoma_biological_and_clinical_implications" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="57666577" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/57666577/Cyclin_D1_and_p16INK4A_expression_predict_reduced_survival_in_carcinoma_of_the_anterior_tongue">Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32482066" href="https://independent.academia.edu/DavidQuinn7">David Quinn</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical cancer research : an official journal of the American Association for Cancer Research, 1999</p><p class="ds-related-work--abstract ds2-5-body-sm">Cyclin D1 and p16INK4A are molecules with pivotal roles in cell cycle control and the development of diverse human cancers, and overexpression of cyclin D1 and loss of p16INK4A expression are common genetic events in head and neck squamous cell carcinoma. The prognostic significance of these molecular events at different sites within the head and neck, however, remains controversial. Thus, we sought to determine the relationship between cyclin D1 and/or p16INK4A expression and disease outcome in squamous cell carcinoma of the anterior tongue. Immunohistochemical detection of nuclear proteins cyclin D1, p53, and p16INK4A, and the Ki-67 labeling index was undertaken in tissue sections from 148 tongue cancers treated by surgical resection. Nuclear antigen status was analyzed in relation to pathological variables, tumor recurrence, and patient survival. Statistical significance was assessed using chi2 analysis for pathological variables and the Kaplan-Meier method, log rank test, and th...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue","attachmentId":72456042,"attachmentType":"pdf","work_url":"https://www.academia.edu/57666577/Cyclin_D1_and_p16INK4A_expression_predict_reduced_survival_in_carcinoma_of_the_anterior_tongue","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/57666577/Cyclin_D1_and_p16INK4A_expression_predict_reduced_survival_in_carcinoma_of_the_anterior_tongue"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="30306022" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30306022/Studies_of_the_cell_cycle_regulatory_proteins_P16_cyclin_D1_and_retinoblastoma_protein_in_laryngeal_carcinoma_tissue">Studies of the cell cycle regulatory proteins P16, cyclin D1 and retinoblastoma protein in laryngeal carcinoma tissue</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="30669796" href="https://am-wroc.academia.edu/MarcinFr%C4%85czek">Marcin Frączek</a></div><p class="ds-related-work--abstract ds2-5-body-sm">The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting you access and read them immediately.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Studies of the cell cycle regulatory proteins P16, cyclin D1 and retinoblastoma protein in laryngeal carcinoma tissue","attachmentId":50763480,"attachmentType":"pdf","work_url":"https://www.academia.edu/30306022/Studies_of_the_cell_cycle_regulatory_proteins_P16_cyclin_D1_and_retinoblastoma_protein_in_laryngeal_carcinoma_tissue","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/30306022/Studies_of_the_cell_cycle_regulatory_proteins_P16_cyclin_D1_and_retinoblastoma_protein_in_laryngeal_carcinoma_tissue"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="6079973" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/6079973/Altered_expression_and_activity_of_G1_S_cyclins_and_cyclin_dependent_kinases_characterize_squamous_cell_carcinomas_of_the_head_and_neck">Altered expression and activity of G1/S cyclins and cyclin-dependent kinases characterize squamous cell carcinomas of the head and neck</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="9157839" href="https://independent.academia.edu/G1patel">G1 patel</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Cancer, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Altered expression and activity of G1/S cyclins and cyclin-dependent kinases characterize squamous cell carcinomas of the head and neck","attachmentId":49026847,"attachmentType":"pdf","work_url":"https://www.academia.edu/6079973/Altered_expression_and_activity_of_G1_S_cyclins_and_cyclin_dependent_kinases_characterize_squamous_cell_carcinomas_of_the_head_and_neck","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/6079973/Altered_expression_and_activity_of_G1_S_cyclins_and_cyclin_dependent_kinases_characterize_squamous_cell_carcinomas_of_the_head_and_neck"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="58126864" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/58126864/Comparison_between_immunohistochemical_expression_of_cyclin_D1_and_p21_and_histological_malignancy_graduation_of_oral_squamous_cell_carcinomas">Comparison between immunohistochemical expression of cyclin D1 and p21 and histological malignancy graduation of oral squamous cell carcinomas</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33314819" href="https://independent.academia.edu/ADaCostaNeves">A Da Costa Neves</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brazilian Dental Journal</p><p class="ds-related-work--abstract ds2-5-body-sm">The objective of the present study was to correlate the expression of cyclin D1 with the expression of p21 in 28 cases of oral squamous cell carcinoma (OSCC), as well as to compare the expression of both with a histological graduation of this neoplasm. Immunohistochemistry was used to obtain the expression of cyclin D1 and p21. The results of statistical analysis showed no correlation between the expression of cyclin D1 and p21. Also, there was no correlation between the mean numbers of cyclin D1 positive nuclei and p21 positive nuclei and the histological scores of malignancy. However, the marked expression of cyclin D1 in high-grade tumors supports its role in proliferative activity. In contrast, p21 seems unable to arrest tumor progression in OSCC.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Comparison between immunohistochemical expression of cyclin D1 and p21 and histological malignancy graduation of oral squamous cell carcinomas","attachmentId":72690151,"attachmentType":"pdf","work_url":"https://www.academia.edu/58126864/Comparison_between_immunohistochemical_expression_of_cyclin_D1_and_p21_and_histological_malignancy_graduation_of_oral_squamous_cell_carcinomas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/58126864/Comparison_between_immunohistochemical_expression_of_cyclin_D1_and_p21_and_histological_malignancy_graduation_of_oral_squamous_cell_carcinomas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="7642042" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/7642042/Cell_cycle_proteins_and_the_development_of_oral_squamous_cell_carcinoma">Cell cycle proteins and the development of oral squamous cell carcinoma</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="13835729" href="https://stanford.academia.edu/AlexMcMillan">Alex McMillan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Oral Oncology, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cell cycle proteins and the development of oral squamous cell carcinoma","attachmentId":48387385,"attachmentType":"pdf","work_url":"https://www.academia.edu/7642042/Cell_cycle_proteins_and_the_development_of_oral_squamous_cell_carcinoma","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/7642042/Cell_cycle_proteins_and_the_development_of_oral_squamous_cell_carcinoma"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="125453979" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/125453979/Immunohistochemical_Expression_of_Cyclin_D1_in_Conventional_Squamous_Cell_Carcinoma_of_Oral_Cavity">Immunohistochemical Expression of Cyclin D1 in Conventional Squamous Cell Carcinoma of Oral Cavity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="317283879" href="https://independent.academia.edu/SumaiyaShahab2">Sumaiya Shahab</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Ayub Medical College Abbottabad</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity, the incidence of which has significantly increased in the last 10 years. In Pakistan, it is reported to be the most common cancer among men and the second most common in women. Cyclin D1 is a protein involved in cell cycle regulation from G1 phase to S phase. Down regulation of this molecule causes inhibition of cell cycle transition and may lead to carcinogenesis. We studied the expression of Cyclin D1 in biopsies of oral squamous cell carcinoma to evaluate the staining patterns in various grades and sites of the oral cavity. Cyclin D1 was expressed in 53.8% cases of OSCC and showed a significant association with tumour differentiation, with higher intensity staining seen in poorly differentiated cases of OSCC. Thus, Cyclin D1 can be regarded as a marker of malignant potential of OSCC and can help identify cases with poorer outcome.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunohistochemical Expression of Cyclin D1 in Conventional Squamous Cell Carcinoma of Oral Cavity","attachmentId":119494026,"attachmentType":"pdf","work_url":"https://www.academia.edu/125453979/Immunohistochemical_Expression_of_Cyclin_D1_in_Conventional_Squamous_Cell_Carcinoma_of_Oral_Cavity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/125453979/Immunohistochemical_Expression_of_Cyclin_D1_in_Conventional_Squamous_Cell_Carcinoma_of_Oral_Cavity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="28336675" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/28336675/Cyclin_D1_Expression_and_Its_Correlation_with_Histopathological_Differentiation_in_Oral_Squamous_Cell_Carcinoma">Cyclin D1 Expression and Its Correlation with Histopathological Differentiation in Oral Squamous Cell Carcinoma</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="53134619" href="https://independent.academia.edu/MadhusudanAstekar">Madhusudan Astekar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Scientific World Journal, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cyclin D1 Expression and Its Correlation with Histopathological Differentiation in Oral Squamous Cell Carcinoma","attachmentId":48669455,"attachmentType":"pdf","work_url":"https://www.academia.edu/28336675/Cyclin_D1_Expression_and_Its_Correlation_with_Histopathological_Differentiation_in_Oral_Squamous_Cell_Carcinoma","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/28336675/Cyclin_D1_Expression_and_Its_Correlation_with_Histopathological_Differentiation_in_Oral_Squamous_Cell_Carcinoma"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="93500557" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/93500557/Expression_of_cyclin_D1_p27_p21_bcl_2_and_p53_in_laryngeal_squamous_cell_carcinoma_and_an_investigation_of_the_correlation_with_conventional_prognostic_factors">Expression of cyclin D1, p27, p21, bcl-2, and p53 in laryngeal squamous cell carcinoma and an investigation of the correlation with conventional prognostic factors</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="250822638" href="https://independent.academia.edu/g%C3%BCl%C3%A7ing%C3%BCler%C5%9Fim%C5%9Fek">gülçin güler şimşek</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Turkish Journal of Medical Sciences</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Expression of cyclin D1, p27, p21, bcl-2, and p53 in laryngeal squamous cell carcinoma and an investigation of the correlation with conventional prognostic factors","attachmentId":96221518,"attachmentType":"pdf","work_url":"https://www.academia.edu/93500557/Expression_of_cyclin_D1_p27_p21_bcl_2_and_p53_in_laryngeal_squamous_cell_carcinoma_and_an_investigation_of_the_correlation_with_conventional_prognostic_factors","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/93500557/Expression_of_cyclin_D1_p27_p21_bcl_2_and_p53_in_laryngeal_squamous_cell_carcinoma_and_an_investigation_of_the_correlation_with_conventional_prognostic_factors"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="87495052" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/87495052/Evaluation_of_Cyclin_D1_expression_in_Head_and_Neck_Squamous_Cell_Carcinoma">Evaluation of Cyclin D1 expression in Head and Neck Squamous Cell Carcinoma</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="48000299" href="https://independent.academia.edu/VatsalaMisra">Vatsala Misra</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of clinical and diagnostic research : JCDR, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Squamous Cell Carcinoma (SCC) is an aggressive epithelial malignancy of the upper aero digestive tract and comprises 90% of all Head and Neck Squamous Cell Carcinoma (HNSCC). It is the sixth leading cancer worldwide with approximately 600,000 cases reported annually. It is one of the most common cancers in India. Tumour Lymph Node and Metastases (TNM) staging has been the most useful indicator to predict prognosis in HNSCC but recently various biomolecular markers have potentially offered new methods for early diagnosis and treatment alternatives for HNSCC patients; one amongst them being cyclin D1. This study has been undertaken to evaluate expression of cyclin D1 in HNSCC cases and to find out its association with various pathological prognostic factors. A 48 formalin fixed paraffin embedded tumour sections, stained with Haematoxylin & Eosin were graded and staged. Immunohistochemistry for cyclin D1 was evaluated as Extent Score (ES), Intensity Score (IS) and Total Score (TS) was ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evaluation of Cyclin D1 expression in Head and Neck Squamous Cell Carcinoma","attachmentId":91687225,"attachmentType":"pdf","work_url":"https://www.academia.edu/87495052/Evaluation_of_Cyclin_D1_expression_in_Head_and_Neck_Squamous_Cell_Carcinoma","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/87495052/Evaluation_of_Cyclin_D1_expression_in_Head_and_Neck_Squamous_Cell_Carcinoma"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="88936489" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/88936489/Distribution_and_prognostic_significance_of_cell_cycle_proteins_in_squamous_carcinoma_of_the_larynx_hypopharynx_and_adjacent_epithelial_hyperplastic_lesions">Distribution and prognostic significance of cell cycle proteins in squamous carcinoma of the larynx, hypopharynx and adjacent epithelial hyperplastic lesions</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36982252" href="https://independent.academia.edu/GaleNina">Nina Gale</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Laryngology & Otology, 2003</p><p class="ds-related-work--abstract ds2-5-body-sm">Alterations of cell cycle proteins contribute to the development and biological behaviour of malignant tumours. We evaluated the distribution and prognostic significance of immunohistochemically detected proteins p53, p21, Rb, and cyclin D1 in 101 laryngeal and hypopharyngeal squamous cell carcinomas (SCC) and adjacent epithelial hyperplastic lesions (EHL). Protein expression was correlated with tumour grade and stage.Varying patterns of protein expression were found in SCC. A significant correlation (p &lt;0.05) was found between Rb expression and tumour grade. Different grades of EHL exhibited randomly distributed p53 and cyclin D1 positive cell clusters with no association to the pattern of their expression in SCC.Our study demonstrated derailment of cell cycle regulation in almost all cases of SCC of the larynx and hypopharynx. However, only cyclin D1 expression had an independent prognostic value for cancer-specific survival. The results also suggest that Rb gene inactivation, ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Distribution and prognostic significance of cell cycle proteins in squamous carcinoma of the larynx, hypopharynx and adjacent epithelial hyperplastic lesions","attachmentId":92823695,"attachmentType":"pdf","work_url":"https://www.academia.edu/88936489/Distribution_and_prognostic_significance_of_cell_cycle_proteins_in_squamous_carcinoma_of_the_larynx_hypopharynx_and_adjacent_epithelial_hyperplastic_lesions","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/88936489/Distribution_and_prognostic_significance_of_cell_cycle_proteins_in_squamous_carcinoma_of_the_larynx_hypopharynx_and_adjacent_epithelial_hyperplastic_lesions"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":46081491,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":46081491,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_46081491" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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