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{"work":{"id":91151259,"created_at":"2022-11-19T10:44:18.699-08:00","from_world_paper_id":220727704,"updated_at":"2024-11-24T20:28:58.788-08:00","_data":{"publisher":"EDP Sciences","grobid_abstract":"The spontaneous assembly of amphiphiles into micelles and bilayer membranes, as well as the dynamical self-assembly properties of nucleic acids, suggest that selforganization phenomena played a role in the origin of life. However, current biology indicates that life could have not evolved in the absence of a genetic replicating mechanism insuring the stability and diversification of its basic components. This does not imply that explanations on the appearance of life should reduce themselves to the issue of the emergence of RNA or its predecessors.","publication_date":"2009,,","publication_name":"Origins of Life: Self-Organization and/or Biological Evolution?","grobid_abstract_attachment_id":"94519444"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Complexity, self-organization and the origin of life: The happy liaison?","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [166029032]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":94519444,"attachmentType":"pdf"}"><img alt="First page of “Complexity, self-organization and the origin of life: The happy liaison?”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/94519444/mini_magick20221119-1-1darbsq.png?1668883490" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Complexity, self-organization and the origin of life: The happy liaison?</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="166029032" href="https://unam1.academia.edu/antoniolazcano"><img alt="Profile image of antonio lazcano" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />antonio lazcano</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2009, Origins of Life: Self-Organization and/or Biological Evolution?</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">10 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 91151259; 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if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">The spontaneous assembly of amphiphiles into micelles and bilayer membranes, as well as the dynamical self-assembly properties of nucleic acids, suggest that selforganization phenomena played a role in the origin of life. However, current biology indicates that life could have not evolved in the absence of a genetic replicating mechanism insuring the stability and diversification of its basic components. This does not imply that explanations on the appearance of life should reduce themselves to the issue of the emergence of RNA or its predecessors.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":94519444,"attachmentType":"pdf","workUrl":"https://www.academia.edu/91151259/Complexity_self_organization_and_the_origin_of_life_The_happy_liaison"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":94519444,"attachmentType":"pdf","workUrl":"https://www.academia.edu/91151259/Complexity_self_organization_and_the_origin_of_life_The_happy_liaison"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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Monaco</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Citeseer</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Self-Organization, Autocatalysis and Models of the Origin of Life","attachmentId":1888080,"attachmentType":"pdf","work_url":"https://www.academia.edu/393094/Self_Organization_Autocatalysis_and_Models_of_the_Origin_of_Life","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/393094/Self_Organization_Autocatalysis_and_Models_of_the_Origin_of_Life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="61384992" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/61384992/Self_organization_at_the_origin_of_life">Self-organization at the origin of life</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="57588505" href="https://independent.academia.edu/AthelCornishBowden">Athel Cornish-Bowden</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Theoretical Biology, 2008</p><p class="ds-related-work--abstract ds2-5-body-sm">The concept of an ðM; RÞ system with organizational invariance allows one to understand how a system may be able to maintain itself indefinitely if it is coupled to an external source of energy and materials. However, although this constitutes an important step towards understanding the difference between a living and a non-living system, it is not clear that an ðM; RÞ system with organizational invariance is sufficient to define a living system. To take a further step towards defining what it means to be alive it is necessary to add to a simple ðM; RÞ system some property that represents its identity, and which can be maintained and modified in subsequent generations.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Self-organization at the origin of life","attachmentId":74431355,"attachmentType":"pdf","work_url":"https://www.academia.edu/61384992/Self_organization_at_the_origin_of_life","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/61384992/Self_organization_at_the_origin_of_life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="17829838" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17829838/The_Origins_of_Cellular_Life">The Origins of Cellular Life</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37748080" href="https://independent.academia.edu/SzostakJack">Jack Szostak</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cold Spring Harbor Perspectives in Biology, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Understanding the origin of cellular life on Earth requires the discovery of plausible pathways for the transition from complex prebiotic chemistry to simple biology, defined as the emergence of chemical assemblies capable of Darwinian evolution. We have proposed that a simple primitive cell, or protocell, would consist of two key components: a protocell membrane that defines a spatially localized compartment, and an informational polymer that allows for the replication and inheritance of functional information. Recent studies of vesicles composed of fatty-acid membranes have shed considerable light on pathways for protocell growth and division, as well as means by which protocells could take up nutrients from their environment. Additional work with genetic polymers has provided insight into the potential for chemical genome replication and compatibility with membrane encapsulation. The integration of a dynamic fatty-acid compartment with robust, generalized genetic polymer replication would yield a laboratory model of a protocell with the potential for classical Darwinian biological evolution, and may help to evaluate potential pathways for the emergence of life on the early Earth. Here we discuss efforts to devise such an integrated protocell model.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Origins of Cellular Life","attachmentId":42224499,"attachmentType":"pdf","work_url":"https://www.academia.edu/17829838/The_Origins_of_Cellular_Life","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17829838/The_Origins_of_Cellular_Life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="103240245" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/103240245/Origins_of_Life_Chemical_and_Philosophical_Approaches">Origins of Life: Chemical and Philosophical Approaches</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="115505210" href="https://independent.academia.edu/VeraKolb">Vera Kolb</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Evolutionary Biology, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">In this article we address selected important milestones of chemical evolution that led to life. The first such milestone could be achieved by Oparin's model, which accounts for the early stages of chemical evolution. These occurred at the dawn of development of primitive chemical systems that were pre-RNA. Oparin's model consists of spontaneous formation of coacervates that encapsulate chemical matter, undergo primitive self-replication, and provide a pathway to a primitive metabolism. We review the experimental updates of his model from our laboratory and discuss types of selection that could have occurred in these primitive systems. Another major milestone in chemical evolution is the transition from abiotic to biotic. This has occurred later, after the RNA world evolved. A controversy of what life is interferes with the efforts to elucidate this transition. Thus, we present various definitions of life, some of which specifically include the requirements and mechanisms for this transition. Selfreplication is one of the major requirements for life. In this context we reexamine the question if viruses, which do not have capability to self-replicate, are alive. We draw on philosophy of Hegel, Aristotle, Rescher, Priest, and Fry to guide us in our endeavors. Specifically, we apply Hegel's law on quantity-to-quality transition to abiotic-to-biotic transition, Aristotle's philosophy to the definition of life, Priest's dialetheism to the question if viruses are alive or not, Fry's philosophy to the beginning of natural selection in chemical evolution, and Rescher's philosophy to the possible cognitive bias toward simple definitions of life.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Origins of Life: Chemical and Philosophical Approaches","attachmentId":103299828,"attachmentType":"pdf","work_url":"https://www.academia.edu/103240245/Origins_of_Life_Chemical_and_Philosophical_Approaches","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/103240245/Origins_of_Life_Chemical_and_Philosophical_Approaches"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="126864745" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/126864745/Origins_of_Life_The_Primal_Self_Organization">Origins of Life: The Primal Self-Organization</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="315482367" href="https://independent.academia.edu/DirkHennerLankenau">Dirk-Henner Lankenau</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Origins of Life: The Primal Self-Organization, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Origins of Life: The Primal Self-Organization","attachmentId":120680167,"attachmentType":"pdf","work_url":"https://www.academia.edu/126864745/Origins_of_Life_The_Primal_Self_Organization","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/126864745/Origins_of_Life_The_Primal_Self_Organization"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="22456214" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/22456214/Physico_Chemical_and_Evolutionary_Constraints_for_the_Formation_and_Selection_of_First_Biopolymers_Towards_the_Consensus_Paradigm_of_the_Abiogenic_Origin_of_Life">Physico-Chemical and Evolutionary Constraints for the Formation and Selection of First Biopolymers: Towards the Consensus Paradigm of the Abiogenic Origin of Life</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43947806" href="https://independent.academia.edu/Galperin">Michael Y Galperin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Chemistry & Biodiversity, 2007</p><p class="ds-related-work--abstract ds2-5-body-sm">During the last two decades, the common school of thought has split into two, so that the problem of the origin of life is tackled in the framework of either the replication first paradigm or the metabolism first scenario. The first paradigm suggests that the life started from the spontaneous emergence of the first, supposedly RNA-based replicators and considers in much detail their further evolution in the socalled RNA world. The alternative hypothesis of metabolism first derives the life from increasingly complex autocatalytic chemical cycles. In this work, we emphasize the role of selection during the prebiological stages of evolution and focus on the constraints that are imposed by physical, chemical, and biological laws. We try to demonstrate that the replication first and metabolism first hypotheses complement, rather than contradict, each other. We suggest that life on Earth has started from a metabolism-driven replication; the suggested scenario might serve as a consensus scheme in the framework of which the molecular details of origin of life can be further elaborated. The key feature of the scenario is the participation of the UV irradiation both as driving and selecting forces during the earlier stages of evolution.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Physico-Chemical and Evolutionary Constraints for the Formation and Selection of First Biopolymers: Towards the Consensus Paradigm of the Abiogenic Origin of Life","attachmentId":43073473,"attachmentType":"pdf","work_url":"https://www.academia.edu/22456214/Physico_Chemical_and_Evolutionary_Constraints_for_the_Formation_and_Selection_of_First_Biopolymers_Towards_the_Consensus_Paradigm_of_the_Abiogenic_Origin_of_Life","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/22456214/Physico_Chemical_and_Evolutionary_Constraints_for_the_Formation_and_Selection_of_First_Biopolymers_Towards_the_Consensus_Paradigm_of_the_Abiogenic_Origin_of_Life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":94519444,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":94519444,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_94519444" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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