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Humanized Mice | Immuno-Oncology Assays
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Site Effects In Vivo PBMC Recruitment ","description":"<p><strong>A.<\/strong> M3 compact MRI from Aspect imaging <strong>B.<\/strong> Growth curves of a liposarcoma PDX model (<a href=\"https:\/\/oncointel.certisoncology.com\/model\/872bf179-4ad8-440e-8c36-944cb3c1bda7\" target=\"_blank\" rel=\"noopener\">BarneyOI<sup>\u00ae<\/sup> Model CRT00395<\/a>) implanted in the rear flank or abdomen of PBMC-humanized animals. <strong>C.<\/strong> Confirmation of PD-L1 status by spectral flow cytometry. <strong>D.<\/strong> Differential TIL recruitment and immunophenotypes of untreated tumors in locations (n=8).<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f6e3c3648fee><component-5f85e99dcff4d :arr="{"headline":"","content":"<h2>Harnessing the Power of the Human Immune System<\/h2>\n<p>Certis offers a suite of immuno-oncology assays that can be customized to meet specified study endpoints, including:<\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Target expression and validation<\/li>\n<li>Immune cell phenotyping<\/li>\n<li>Immune cell viability and apoptosis<\/li>\n<li>Immune cell stimulation, activation, function, and exhaustion<\/li>\n<li>Immune cell proliferation and expansion<\/li>\n<li>Immune cell differentiation, effector vs. memory<\/li>\n<li>Tumor cell killing assays and characterization<\/li>\n<li>Multiplex cytokine and chemokine assays<\/li>\n<li>Drug-mediated enhancement and inhibition of immune response<\/li>\n<li>Cancer stem cell marker screening and identification<\/li>\n<li>Advanced and basic flow cytometry analysis<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","cta":"","image":[{"ID":1163,"id":1163,"title":"background-tumor-lg","filename":"background-tumor-lg-e1623254884797.jpg","filesize":128046,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-e1623254884797.jpg","link":"https:\/\/www.certisoncology.com\/background-tumor-lg\/","alt":"","author":"1","description":"","caption":"","name":"background-tumor-lg","status":"inherit","uploaded_to":0,"date":"2020-10-16 23:43:20","modified":"2021-06-09 16:08:06","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":590,"height":1600,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-e1623254884797-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-720x266.jpg","medium-width":300,"medium-height":111,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-768x283.jpg","medium_large-width":768,"medium_large-height":283,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-960x354.jpg","large-width":960,"large-height":354,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-e1623254884797-566x1536.jpg","1536x1536-width":566,"1536x1536-height":1536,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-e1623254884797.jpg","2048x2048-width":590,"2048x2048-height":1600,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-e1623254884797-540x1464.jpg","small-width":540,"small-height":1464,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-e1623254884797-540x540.jpg","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-e1623254884797-590x720.jpg","square-md-width":590,"square-md-height":720,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-e1623254884797-590x920.jpg","portrait-width":590,"portrait-height":920,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-lg-e1623254884797-590x640.jpg","landscape-width":590,"landscape-height":640}},{"ID":1167,"id":1167,"title":"background-tumor-sm","filename":"background-tumor-sm-e1605637081934.jpg","filesize":95766,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934.jpg","link":"https:\/\/www.certisoncology.com\/background-tumor-sm\/","alt":"","author":"1","description":"","caption":"","name":"background-tumor-sm","status":"inherit","uploaded_to":0,"date":"2020-10-16 23:48:46","modified":"2024-02-13 19:46:22","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":1200,"height":888,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934-720x533.jpg","medium-width":300,"medium-height":222,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934-768x568.jpg","medium_large-width":768,"medium_large-height":568,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934-960x710.jpg","large-width":960,"large-height":710,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934.jpg","1536x1536-width":1200,"1536x1536-height":888,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934.jpg","2048x2048-width":1200,"2048x2048-height":888,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934-540x400.jpg","small-width":540,"small-height":400,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934-540x540.jpg","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934-720x720.jpg","square-md-width":720,"square-md-height":720,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934-640x888.jpg","portrait-width":640,"portrait-height":888,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/background-tumor-sm-e1605637081934-960x640.jpg","landscape-width":960,"landscape-height":640}}]}"></component-5f85e99dcff4d><component-5f6e3c3648fee :arr="{"headline":"","content":"<h2>Our suite of assays for immuno-oncology<\/h2>\n<ul>\n<li>IncuCyte<sup>\u00ae<\/sup> live cell imaging and analysis for developing tumor cell-killing assays<\/li>\n<li>Histology-based assays for assessing spatial distribution of immune response and tumor cells<\/li>\n<li>Spectral flow cytometry multiparameter analysis, including multicolor immune phenotyping of TILs and PBMCs for unraveling cellular and molecular mechanisms of action (MOAs), and for biomarker development<\/li>\n<li>PD modulation downstream of targeted protein signaling, including measuring pMEK & pERK <em>in vitro<\/em> models or in <em>ex vivo<\/em> human whole blood assays (and in humanized mice as preclinical proof of concept for driving PKPD correlation)<\/li>\n<li>CAR-T Cell Assays<\/li>\n<\/ul>\n","cta":"","media-option":"image","image":{"image":{"ID":6786,"id":6786,"title":"InCuCyte Video_ Model 361_parental","filename":"InCuCyte-Video_-Model-361_parental.gif","filesize":741999,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental.gif","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/immuno-oncology\/incucyte-video_-model-361_parental\/","alt":"","author":"6","description":"","caption":"","name":"incucyte-video_-model-361_parental","status":"inherit","uploaded_to":5918,"date":"2024-02-13 20:09:16","modified":"2024-02-13 20:09:16","menu_order":0,"mime_type":"image\/gif","type":"image","subtype":"gif","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":600,"height":443,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental-150x150.gif","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental.gif","medium-width":300,"medium-height":222,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental.gif","medium_large-width":600,"medium_large-height":443,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental.gif","large-width":600,"large-height":443,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental.gif","1536x1536-width":600,"1536x1536-height":443,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental.gif","2048x2048-width":600,"2048x2048-height":443,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental-540x399.gif","small-width":540,"small-height":399,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental-540x443.gif","square-sm-width":540,"square-sm-height":443,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental.gif","square-md-width":600,"square-md-height":443,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental.gif","portrait-width":600,"portrait-height":443,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/InCuCyte-Video_-Model-361_parental.gif","landscape-width":600,"landscape-height":443}},"href":{"title":"BarneyOI Cancer Model CRT00361","url":"https:\/\/oncointel.certisoncology.com\/model\/d1f973ea-5503-4680-826c-2beb5e4540fd","target":"_blank"},"title":"Developing a Tumor Cell-Killing Assay","description":"<p>Certis rechallenges the cell line morphology of <a href=\" https:\/\/oncointel.certisoncology.com\/model\/d1f973ea-5503-4680-826c-2beb5e4540fd\/\" target=\"_blank\" rel=\"noopener\">BarneyOI Cancer Model CRT00361<\/a> after cumulative doses of radiation. Study results reveal that increasing radiation dosages decrease growth kinetics. IncuCyte red fluorescence shows late stages of cell death\/apoptosis.<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f6e3c3648fee><component-5f6e3c3648fee :arr="{"headline":"","content":"<h2>In Vitro Testing and Validation Case Study<\/h2>\n<p>This study showed that HER2-specific CAR-T cells significantly inhibit tumor cell growth and drive apoptosis. Certis generated HER2-targeting CAR-T cells from a HER2+ A549 tumor line. IncuCyte live cell imaging was used to test therapeutic efficacy and CAR-T cell assay validation was conducted with spectral flow cytometry. Results indicated significant tumor cell growth inhibition and apoptosis. Spectral flow observations for various immune effector markers and cell differentiation status were in concordance with tumor lytic ability of HER2 CAR-T cells.<\/p>\n","cta":"","media-option":"image","image":{"image":{"ID":6752,"id":6752,"title":"IO-two-charts-optimized","filename":"IO-two-charts-optimized.png","filesize":90069,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized.png","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/immuno-oncology\/io-two-charts-optimized\/","alt":"","author":"6","description":"","caption":"","name":"io-two-charts-optimized","status":"inherit","uploaded_to":5918,"date":"2024-02-13 02:23:13","modified":"2024-02-13 02:23:13","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":720,"height":613,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized.png","medium-width":300,"medium-height":255,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized.png","medium_large-width":720,"medium_large-height":613,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized.png","large-width":720,"large-height":613,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized.png","1536x1536-width":720,"1536x1536-height":613,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized.png","2048x2048-width":720,"2048x2048-height":613,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized-540x460.png","small-width":540,"small-height":460,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized-540x540.png","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized.png","square-md-width":720,"square-md-height":613,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized-640x613.png","portrait-width":640,"portrait-height":613,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IO-two-charts-optimized.png","landscape-width":720,"landscape-height":613}},"href":"","title":"","description":""},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"right to left","vertical-align":"top"}}"></component-5f6e3c3648fee><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h2>Supporting Novel Strategies in Immuno-Oncology<\/h2>\n<p>The lack of clinical translation for several immunotherapies as monotherapies or in combination with checkpoint inhibitors is driving new strategies to advance the field. These strategies consider the complexity of immune cell\u2013cancer cell interactions and the complex cell networks that exist within tumors and among cancer types.<span class=\"tooltip\"><sup id=\"6302\">1<\/sup><\/span> Further opportunity for expansion in immunotherapy involves immune checkpoint inhibitor research through combinational approaches with radiotherapy, chemotherapy, and surgery. There are hundreds of studies being conducted on the efficacy of chemotherapy in combination with PD-1 and PD-L1 blockades. Other studies are investigating the effect of radiotherapy or surgery in combination with checkpoint inhibitors.<\/p>\n<p>Certis can help you evaluate the response of your single immuno-oncology drug agent and\/or agent combinations \u2013 from CAR-T and immune checkpoint inhibitors to antibody-drug conjugates (ADCs), neoantigens, bi-specifics and more.<\/p>\n","cta":{"title":"LEARN MORE","url":"https:\/\/www.certisoncology.com\/for-drug-developers\/custom-model-development\/","target":""}}],"media-option":"image","image":{"image":{"ID":6706,"id":6706,"title":"Xray_paris-jasmine-running-scan","filename":"Xray_paris-jasmine-running-scan.jpg","filesize":1411207,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan.jpg","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/immuno-oncology\/xray_paris-jasmine-running-scan\/","alt":"","author":"6","description":"","caption":"","name":"xray_paris-jasmine-running-scan","status":"inherit","uploaded_to":5918,"date":"2024-02-12 22:33:24","modified":"2024-02-12 22:33:24","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":1950,"height":1301,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan-720x480.jpg","medium-width":300,"medium-height":200,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan-768x512.jpg","medium_large-width":768,"medium_large-height":512,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan-960x640.jpg","large-width":960,"large-height":640,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan-1536x1025.jpg","1536x1536-width":1536,"1536x1536-height":1025,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan.jpg","2048x2048-width":1950,"2048x2048-height":1301,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan-540x360.jpg","small-width":540,"small-height":360,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan-540x540.jpg","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan-720x720.jpg","square-md-width":720,"square-md-height":720,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan-640x920.jpg","portrait-width":640,"portrait-height":920,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray_paris-jasmine-running-scan-960x640.jpg","landscape-width":960,"landscape-height":640}},"href":"","title":"Precision Radiation + Humanized Mice","description":"<p>With our targeted radiation technology, Certis can deliver precise radiation doses to humanized models to evaluate your immune-activating therapeutic candidates, such as CAR-T therapies. Rather than using whole body irradiation, our precise radiation helps to keep the animals\u2019 immune systems in tact. <\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h2>I-O Therapies for Solid Tumors<\/h2>\n<p>It\u2019s not enough to evaluate immune-drug response in humanized mice. Well-established limitations of genetically engineered mouse models (GEMMs), syngeneic mouse models, and subcutaneous mouse models have translational oncology researchers seeking out preclinical models that better recapitulate the tumor microenvironment and more reliably reconstitute human immunity.<span class=\"tooltip\"><sup id=\"4339\">2<\/sup><\/span><\/p>\n","cta":{"title":"GET STARTED","url":"#Enter-your-information","target":""}}],"media-option":"image","image":{"image":{"ID":6864,"id":6864,"title":"Humanized-PDX-Models-Applications-720x579-fixed-optimized","filename":"Humanized-PDX-Models-Applications-720x579-fixed-optimized.webp","filesize":66840,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized.webp","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/immuno-oncology\/humanized-pdx-models-applications-720x579-fixed-optimized\/","alt":"","author":"6","description":"","caption":"","name":"humanized-pdx-models-applications-720x579-fixed-optimized","status":"inherit","uploaded_to":5918,"date":"2024-02-16 21:39:01","modified":"2024-02-16 21:39:01","menu_order":0,"mime_type":"image\/webp","type":"image","subtype":"webp","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":720,"height":579,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized-150x150.webp","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized.webp","medium-width":300,"medium-height":241,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized.webp","medium_large-width":720,"medium_large-height":579,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized.webp","large-width":720,"large-height":579,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized.webp","1536x1536-width":720,"1536x1536-height":579,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized.webp","2048x2048-width":720,"2048x2048-height":579,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized-540x434.webp","small-width":540,"small-height":434,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized-540x540.webp","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized.webp","square-md-width":720,"square-md-height":579,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized-640x579.webp","portrait-width":640,"portrait-height":579,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Humanized-PDX-Models-Applications-720x579-fixed-optimized.webp","landscape-width":720,"landscape-height":579}},"href":"","title":"Applications in Immunotherapy","description":"<p> There are a multitude of applications for humanized PDX models.<span class=\"tooltip\"><sup id=\"4339\">2<\/sup><\/span> Talk to us about our PDX autologous TIL inventory today. <\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"right to left","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e4355bed24 :arr="{"content":"<h2>Getting an Early Read with CertisAI\u2122<\/h2>\n<p>The lack of clinical translation for several immunotherapies as monotherapies or in combination Want to ensure you are getting the best preclinical data to progress your immunotherapy(s) candidates forward, while saving time and money during early-stage decision making? Certis scientists can work with you to customize an AI model that is trained specifically for your investigational I-O compound. Our predictive oncology intelligence platform can recognize biomarker fingerprints and biological pathways predictive of clinical response. <a href=\"https:\/\/www.certisoncology.com\/for-drug-developers\/predictive-oncology-intelligence\/\" rel=\"noopener\">Learn more<\/a>.<\/p>\n<div style=\"text-align: center;\"><img decoding=\"async\" src=\"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Predictor_Selection_Model_Build.svg\" alt=\"\" width=\"90%\" \/><\/div>\n","callout":{"headline":"","content":"","image":false},"layout":{"background":"cells","style":"default","columns":"12","callout-columns":"2"}}"></component-5f6e4355bed24><component-5f6e40ba1bdc4 :arr="{"title":" ","content":"","headline":"Immuno-Oncology Drug Development: Answers to Frequently Asked Questions","items":[{"ID":6309,"post_author":"6","post_date":"2024-01-31 21:27:11","post_date_gmt":"2024-01-31 21:27:11","post_content":"\n<p>Certis can test a full spectrum of immunotherapy candidates preclinically, both<em> in vitro<\/em> and <em>in vivo<\/em>, including cell-based immunotherapies, immunomodulators, cancer vaccines and antibody-based therapies.<\/p>\n","post_title":"What type of immunotherapy candidates are you able to test preclinically?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-type-of-immunotherapy-candidates-are-you-able-to-test-preclinically","to_ping":"","pinged":"","post_modified":"2024-01-31 21:27:11","post_modified_gmt":"2024-01-31 21:27:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6309","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6310,"post_author":"6","post_date":"2024-01-31 21:27:49","post_date_gmt":"2024-01-31 21:27:49","post_content":"\n<p>Yes, Certis is well-versed in testing the efficacy of ADCs. This includes screening of monoclonal antibody (MAb) binding to their tumor-specific antigen (TSA) specificity, cross-reactivity and avidity, immune-modulatory and immunological cell death induced by ADCs, target modulation\/pharmacodynamic read out, on-target\/off-tumor reactivity, anti-drug antibody screen, studying mechanisms of resistance, and more for combinational therapy.<\/p>\n","post_title":"Does Certis have experience working with antibody-drug conjugates (ADCs)?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"does-certis-have-experience-working-with-antibody-drug-conjugates-adcs","to_ping":"","pinged":"","post_modified":"2024-02-07 23:41:53","post_modified_gmt":"2024-02-07 23:41:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6310","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6844,"post_author":"6","post_date":"2024-02-16 19:46:17","post_date_gmt":"2024-02-16 19:46:17","post_content":"\n<p>Full-spectrum flow cytometry is significantly more advanced than traditional cytometry. Analyzing the whole spectrum through multiple, more sensitive detectors offers higher sensitivity for the detection of low-expressed antigens, reduces the need for compensations, and increases the ability for multiplexing. <a href=\"https:\/\/www.certisoncology.com\/methods\/flow-cytometry-for-immuno-oncology\/\">Learn more<\/a> about the differences.<\/p>\n","post_title":"What is the difference between spectral flow cytometry and conventional flow cytometry?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-is-the-difference-between-spectral-flow-cytometry-and-conventional-flow-cytometry","to_ping":"","pinged":"","post_modified":"2024-02-16 19:46:18","post_modified_gmt":"2024-02-16 19:46:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6844","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"}],"cta":"","layout":{"background":"","background-offset":""}}"></component-5f6e40ba1bdc4><component-5f7e3c2a849f9 :arr="{"title":"Contact Us Today About Evaluating Your Immune-Activating Therapeutic Candidates","description":"<h3 id=\"Enter-your-information\">Enter your information<a href=\"#Enter-your-information\"><\/a><\/h3>\n","id":"d2c7e296-8077-48de-9a07-bef5ead14e2d","options":{"active":""}}"></component-5f7e3c2a849f9><component-5f6e424bba9c9 :arr="{"headline":"How Can We Help?","description":"","cta":{"title":"Contact Us","url":"https:\/\/www.certisoncology.com\/contact-us\/","target":""},"layout":{"background":"cells","style":"default","sticky":true}}"></component-5f6e424bba9c9> </div> <footer> <div class="container"> <div class="d-flex flex-wrap flex-md-nowrap"> 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