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<main class="page-content"> <div class="hero" style="background-image: url(https://somalogic.com/wp-content/uploads/2023/03/hero-abstract-tumor-scaled.jpg);height: 600px;" title="Hero image of abstract tumor illustration"> <div class="container"> <div class="grid"> <div class="cell-md-9"> <p class="breadcrumbs"><a href="/">Home</a> / Education / Disease Spotlight / <span class="blue">Cancer</span></p> <h1>High-plex protein profiling for cancer research: Maximize target selection and validation</h1> <p>The SomaScan® Assay profiles thousands of proteins in a 55-μL blood sample and efficiently detects low-abundance proteins in complex biological samples.</p> </div> </div> </div> </div><div class="wrap white " id="wrap_0" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="mb-60"><h2 class="a-center">The pioneering <em class="blue">SomaScan® Assay</em> empowers discovery</h2> <p>Understanding changes in protein expression is key to determining cancer dynamics. Critical biomarkers can then be identified when comparing the complete protein profiles of healthy and disease states. The <a href="/somascan-platform/">SomaScan Platform</a> accelerates cancer proteomics by offering high-plex protein analysis and broader coverage of up to half the human proteome. This enables the detection of proteins and protein networks related to the origin, proliferation, and metastasis of solid tumor and blood-based cancers, driving early biomarker discovery and validation for translational science and pre-clinical cancer research. The SomaScan 11K Assay now supports cell lysate and tissue homogenate samples, which allows for a more comprehensive exploration of cancer pathways and mechanisms.</p> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center mt-60"><h2>Cancer-related resources</h2> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class=""><div style="position:relative;width:auto;padding:0 0 25.00%;height:0;top:0;left:0;bottom:0;right:0;margin:0;border:0 none" id="experience-670d38cbca6ad" data-aspectRatio="4.0000" data-mobile-aspectRatio="2.1600"><iframe title="Carousel - Cancer Page" allowfullscreen src="https://view.ceros.com/somalogic/full-width-content-slider-1-1-2-1" style="position:absolute;top:0;left:0;bottom:0;right:0;margin:0;padding:0;border:0 none;height:1px;width:1px;min-height:100%;min-width:100%" frameborder="0" class="ceros-experience" scrolling="no"></iframe></div><script type="text/javascript" src="https://view.ceros.com/scroll-proxy.min.js" data-ceros-origin-domains="view.ceros.com"></script></div> </div></div> </div> </div><div class="wrap grey " id="wrap_1" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-6 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class=""><h2 style="text-align: center">Customize your analysis for <em class="blue">targeted results</em></h2> <p style="text-align: center">You can choose a specialized panel of select protein targets.</p> <p style="text-align: left">Choose from:</p> <ul class="blue-check small"> <li>Your own <a href="https://somalogic.com/somascan-panels/">customized panel</a> of analytes</li> <li>One of our scientist-curated panels specific<br /> to <a href="https://somalogic.com/somascan-panels/">oncology, cytokines</a>, and more</li> </ul> </div> </div><div class="text-block cell-md-6 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><h2 class="mb-30">What&#8217;s your <em class="blue">biomarker challenge</em>?</h2> <div style="position:relative;width:auto;padding:0 0 75.44%;height:0;top:0;left:0;bottom:0;right:0;margin:0;border:0 none" id="experience-6417a4d73ba3e" data-aspectRatio="1.3255"><iframe title="Cancer Page - Biomarker Discovery Section" allowfullscreen src="https://view.ceros.com/somalogic/cancer-page-biomarker-discovery-section" style="position:absolute;top:0;left:0;bottom:0;right:0;margin:0;padding:0;border:0 none;height:1px;width:1px;min-height:100%;min-width:100%" frameborder="0" class="ceros-experience" scrolling="no"></iframe></div><script type="text/javascript" src="https://view.ceros.com/scroll-proxy.min.js" data-ceros-origin-domains="view.ceros.com"></script></div> </div></div> </div> </div><div class="wrap white " id="wrap_2" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center mb-60"><h2>The <em class="blue">SomaScan Assay</em> is the premier high-plex, high-throughput assay for protein profiling</h2> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class=""><div class=""> <div class="table-scroll"> <table style="width: 100%"> <tbody> <tr> <th style="background-color: black"><strong>Feature</strong></th> <th><strong>Benefit</strong></th> </tr> <tr> <td style="background-color: #eef1f2"> <p class="p1">Profiles thousands of different proteins from only 55 μL of plasma/serum</p> </td> <td>Obtain the <a href="https://somalogic.com/somascan-assay-services/">most biological insights</a> into proteins and protein networks – simultaneously</td> </tr> <tr> <td style="background-color: #eef1f2"> <p class="p1">Compatible for use with blood and other complex biological fluids and tissue</p> </td> <td>Eliminate complex sample preparation inherent in <a href="https://somalogic.com/mass-spectrometry/">mass spectrometry</a></td> </tr> <tr> <td style="background-color: #eef1f2">10-log <a href="https://somalogic.com/dynamic-range/">dynamic range</a> from femtomolar to micromolar</td> <td>Achieve <a href="https://somalogic.com/specificity/">sensitive detection</a> of low-abundance proteins</td> </tr> <tr> <td style="background-color: #eef1f2"> <p class="p1">~5% median <a href="https://somalogic.com/coefficients-of-variation/">coefficient of variation</a> (CV)</p> </td> <td>Maintain intra- and inter-assay reproducibility across samples/projects</td> </tr> </tbody> </table> </div> </div> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center mt-60"><h2>Added value features</h2> </div> </div><div class="cards-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0"> <div class=" cards " ><div class="card white owl-block" title=""> <div> <h3>SomaSignal® Tests for pre-analytical variation ensure data accuracy</h3> <p class="a-center"><a href="https://somalogic.com/pre-analytical-variation/" class="btn blue on-white" target="">Learn more</a></p> </div> </div><div class="card white owl-block" title=""> <div> <h3>Life Sciences customer portal provides enhanced data interpretation and visualization</h3> <p class="a-center"><a href="https://somalogic.com/life-sciences-portal/" class="btn blue on-white" target="">Access Portal</a></p> </div> </div><div class="card white owl-block" title=""> <div> <h3>Options for specialized, customized panels</h3> <p class="a-center"><a href="https://somalogic.com/somascan-panels/" class="btn blue on-white" target="">Learn more</a></p> </div> </div></div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><p><a class="btn blue" style="margin-top: 30px" href="https://menu.somalogic.com" target="_blank" rel="noopener">Reveal more proteins with our high-plex menu</a></p> </div> </div></div> </div> </div><div class="wrap black " id="wrap_3" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/07/B2_2_CTA-L-Texture-1.jpeg)" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-6 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class=""><h2>New to proteomics?</h2> <p>The human proteome orchestrates the majority of biological processes.</p> <p>Currently, &gt;90% of drug targets are proteins.<sup>1</sup></p> <p><a class="btn blue" href="https://somalogic.com/why-proteins/">Why harness the power of proteomics?</a></p> </div> </div><div class="text-block cell-md-6 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><div style="background-image: url('https://somalogic.com/wp-content/uploads/2022/05/bideo-bg-scaled.jpg');padding: 96px;background-size: cover"><a class="play-button" href="#modal-video"> </a></div> </div> </div></div> </div> </div><div class="wrap white " id="wrap_4" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><h2>Learn <em class="blue">more</em> about the SomaScan Platform</h2> </div> </div><div class="tabs-block a-center mb-60 cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0"> <div class="tabs"> <div class="tabs-nav"> <div data-id="tab_0" class="active" data-text="Technical Info">Technical Info</div><div data-id="tab_1" data-text="Blogs">Blogs</div> </div> <div data-id="tab_0" class="tab-title active" data-text="Technical Info">Technical Info</div><div class="tab active" id="tab_0"><div class="icon mb-60"> <div><img fetchpriority="high" decoding="async" class="alignnone size-medium wp-image-6688" src="https://somalogic.com/wp-content/uploads/2023/12/Assay5_0_Thumb-232x300.jpg" alt="Cover image of the SomaScan® 11K Assay v5.0 Technical Note" width="232" height="300" srcset="https://somalogic.com/wp-content/uploads/2023/12/Assay5_0_Thumb-232x300.jpg 232w, https://somalogic.com/wp-content/uploads/2023/12/Assay5_0_Thumb-193x250.jpg 193w, https://somalogic.com/wp-content/uploads/2023/12/Assay5_0_Thumb.jpg 440w" sizes="(max-width: 232px) 100vw, 232px" /></div> <div class="pl-40" style="text-align: left;"> <h4>SomaScan 11K Assay v5.0 Tech Note</h4> <p>The SomaScan® Platform is a powerful tool with applications in scientific research and health and wellness. This technical note provides background on the platform itself, as well as performance metrics for the SomaScan 11K Assay v5.0.</p> <p><a class="btn blue" href="https://share.hsforms.com/1jQWm31fWRtGdwkhvRPNDJA3zbc6" target="_blank" rel="noopener">Download</a></p> </div> </div> <div class="icon mb-60"> <div><img decoding="async" class="alignnone size-medium wp-image-1491" src="https://somalogic.com/wp-content/uploads/2022/07/SL00000713-Rev-1-2022-03_Pre-analytical-variation-assessment-_Tech-Note_v1-1-232x300.jpg" alt="SL00000713 Rev 1 2022-03_Pre-analytical variation assessment _Tech Note_v1 -1" width="232" height="300" srcset="https://somalogic.com/wp-content/uploads/2022/07/SL00000713-Rev-1-2022-03_Pre-analytical-variation-assessment-_Tech-Note_v1-1-232x300.jpg 232w, https://somalogic.com/wp-content/uploads/2022/07/SL00000713-Rev-1-2022-03_Pre-analytical-variation-assessment-_Tech-Note_v1-1-193x250.jpg 193w, https://somalogic.com/wp-content/uploads/2022/07/SL00000713-Rev-1-2022-03_Pre-analytical-variation-assessment-_Tech-Note_v1-1.jpg 440w" sizes="(max-width: 232px) 100vw, 232px" /></div> <div class="pl-40" style="text-align: left;"> <h4>Pre-analytical variation assessment for more reliable results</h4> <p>In biomarker discovery, it is critical to assess any pre-analytical variation in order to avoid artificial bias in the intended measurements. <a href="https://somalogic.com/pre-analytical-variation/">Pre-analytical variation may arise</a> from both avoidable and unavoidable factors, resulting in misleading data and incorrect conclusions.</p> <p><a class="btn blue" href="https://share.hsforms.com/1VfQ8JaOESiSnq8PXH1hWdw3zbc6" target="_blank" rel="noopener">Download</a></p> </div> </div> <div class="icon"> <div><img decoding="async" class="alignnone wp-image-6261" src="https://somalogic.com/wp-content/uploads/2023/10/LargestMenuHexWithArrows_11K.svg" alt="Hex icon with 11K in center, representing 11,000 measurable proteins by the SomaScan Assay" width="300" height="313" /></div> <div class="pl-40" style="text-align: left;"> <h4>Ready to explore our menu?</h4> <p>First time user? Click button below, and then click Sign Up to get started.</p> <p><a class="btn blue" href="https://somalogic.com/somascan-menu/" rel="noopener">Explore the menu</a></p> </div> </div> </div><div data-id="tab_1" class="tab-title " data-text="Blogs">Blogs</div><div class="tab " id="tab_1"><div class="icon mb-60"> <div><img loading="lazy" decoding="async" class="alignnone size-medium wp-image-4012" src="https://somalogic.com/wp-content/uploads/2023/03/depositphotos_517904446-stock-photo-acute-lymphoblastic-leukemia-all-cancer-300x198.webp" alt="" width="300" height="198" srcset="https://somalogic.com/wp-content/uploads/2023/03/depositphotos_517904446-stock-photo-acute-lymphoblastic-leukemia-all-cancer-300x198.webp 300w, https://somalogic.com/wp-content/uploads/2023/03/depositphotos_517904446-stock-photo-acute-lymphoblastic-leukemia-all-cancer.webp 600w" sizes="auto, (max-width: 300px) 100vw, 300px" /></div> <div class="pl-40" style="text-align: left;"> <h4>Proteomic profiling for discovery of biomarkers and mechanistic insights into acute myeloid leukemia (AML)</h4> <p><a class="btn blue" href="https://somalogic.com/blog/proteomic-profiling-for-discovery-of-biomarkers-and-mechanistic-insights-into-acute-myeloid-leukemia-aml/" rel="noopener">Read</a></p> </div> </div> <div class="icon mb-60"> <div><img loading="lazy" decoding="async" class="alignnone size-medium wp-image-3926" src="https://somalogic.com/wp-content/uploads/2023/03/blogPreviewBrain-300x240.jpg" alt="Abstract illustration of hands holding brain hologram" width="300" height="240" srcset="https://somalogic.com/wp-content/uploads/2023/03/blogPreviewBrain-300x240.jpg 300w, https://somalogic.com/wp-content/uploads/2023/03/blogPreviewBrain.jpg 678w" sizes="auto, (max-width: 300px) 100vw, 300px" /></div> <div class="pl-40" style="text-align: left;"> <h4>Proteomic screening of stool samples for Inflammatory Bowel Disease and Colorectal Cancer</h4> <p><a class="btn blue" href="https://somalogic.com/blog/proteomic-screening-of-stool-samples-for-inflammatory-bowel-disease-and-colorectal-cancer/" rel="noopener">Read</a></p> </div> </div> </div> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center mt-60"><h2>Dive deeper into how proteomics is <em class="blue">advancing cancer research</em></h2> </div> </div><div class="resources-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0"> <div class="owl-carousel cards " data-items="3"><div class="card owl-block blue resource-card" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/07/MicrosoftTeams-image.png);" title="MicrosoftTeams-image"> <div> <div class="content"> <h3><span>Webinar</span>Proteomic risk scores can help identify high-risk patients and monitor short- and long-term effects of treatment</h3> In this 1-hour discussion, you will learn how large-scale proteomics can be leveraged for multiple applications in the field of oncology. The focus will be on 2 new avenues of oncology research. The first is using proteomic risk scores to monitor the cardiotoxic effects of anthracycline treatment and identify patients who may benefit from cardioprotective therapy. The other is developing blood-based protein tests for stratifying lung cancer susceptibility. From biomarker discovery to medicine application and the potential to inform and impact patients’ standard of care—there is a lot to learn and look forward to in oncology research using proteomics. </div> <p class="a-center"><a href="https://somalogic.com/webinar/digital-proteomics-webinar/" class="btn white-border">Learn more</a></p> </div> </div><div class="card owl-block grey resource-card" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/12/lungTumor-preview-1.jpg);" title="Illustration of lung tumor"> <div> <div class="content"> <h3><span>Poster</span>Aptamer-based analysis of plasma proteome of growing tumors </h3> With proteins, the presence of a tumor is more often accompanied with changes in the levels of endogenous, unmutated proteins in circulation. In this context, knowing which proteins represent the earliest markers or tumor presence would be enormously useful. </div> <p class="a-center"><a href="https://somalogic.com/poster/aptamer-based-analysis-of-plasma-proteome-of-growing-tumors/" class="btn dark-blue-border">Learn more</a></p> </div> </div><div class="card owl-block black blogs resource-card" style="background-image: url(https://somalogic.com/wp-content/uploads/2023/03/depositphotos_517904446-stock-photo-acute-lymphoblastic-leukemia-all-cancer.webp);" title=""> <div> <div class="content"> <h3><span>BLOG</span>Proteomic profiling for discovery of biomarkers and mechanistic insights into acute myeloid leukemia (AML)</h3> Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow that is characterized by the abnormal proliferation of immature myeloid cells. It is the most common type of leukemia among the adult population that accounts for about 80% of all cases1. AML is a complex, genetically heterogeneous disease, which presents challenges for treatment. Although most patients respond to standard intensive chemotherapy, approximately two-thirds of the patients relapse within 18 months to 5 years of the initial treatment2. The bone marrow microenvironment is thought to play a significant role in mediating the persistence of malignant leukemic stem cells. However, the exact nature of bone marrow–leukemic cell interactions is not well understood. </div> <p class="a-center"><a href="https://somalogic.com/blog/proteomic-profiling-for-discovery-of-biomarkers-and-mechanistic-insights-into-acute-myeloid-leukemia-aml/" class="btn blue-border">Learn more</a></p> </div> </div><div class="card owl-block white-bg resource-card" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/07/oncology.jpg);" title="Image of woman looking out a window"> <div> <div class="content"> <h3><span>White paper</span>Circulating protein biomarkers are a promising avenue for predicting patient response to cancer immunotherapies</h3> Cancer Immunotherapy relies on activating or enhancing the antitumor immune response and has taken a central position in cancer treatment modalities. While offering a generally safer and more efficacious alternative to standard chemotherapy and radiotherapy, not all patients respond to immunotherapy, and combination immunotherapies increase cost of treatment and heighten the risk for toxicity-related adverse events. An understanding of the molecular factors that contribute to clinical outcomes could enable improved selection of subject cohorts; therefore, identifying predictive biomarkers of immunotherapy response has become a growing focus of immuno-oncology research. </div> <p class="a-center"><a href="https://somalogic.com/white-paper/circulating-protein-biomarkers-are-a-promising-avenue-for-predicting-patient-response-to-cancer-immunotherapies/" class="btn blue-border">Learn more</a></p> </div> </div></div> </div></div> </div> </div><div class="wrap grey " id="wrap_5" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-5 cell-offset-md-1 cell-sm-12 cell-offset-sm-0" > <div class="pr-40"><blockquote class="transparent" style="background-color: #eef1f2"><p>The study of proteins is <a href="https://investors.somalogic.com/node/7256/pdf" target="_blank" rel="noopener">the missing ‘-omic’</a> in the study of cancer. Having proteomic measurements in our data gives us the strongest case for the integration of genetics, behavior and environment in improving the prediction of disease.”<br /> <span class="author" style="font-size: 14px;line-height: 20px"><b>Elio Riboli</b>, European Prospective Investigation into Cancer and Nutrition (EPIC) Study Coordinator and Principal Investigator</span></p> <p>Professor of Cancer Epidemiology and Prevention,<br /> Imperial College London</p></blockquote> </div> </div><div class="text-block cell-md-5 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="pl-40"><blockquote class="transparent" style="background-color: #eef1f2"><p>In current -omics era, discovery and validation of protein biomarkers are essential for both research and clinical practice having huge impact on early cancer detection, diagnosis improvement, recurrence prevention, therapeutic response monitoring and increased survival outcome. Developing cancer risk-identifier biomarkers that aid both early detection and targeted therapy constitutes an <em class="blue">essential aim</em> of the oncology field.”<br /> <span class="author" style="font-size: 14px;line-height: 20px"><b>Tanase CP, </b><em>et al</em>. Prostate cancer proteomics: Current trends and future perspectives for biomarker discovery. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392345/ " target="_blank" rel="noopener">Oncotarget</a>. </span></p></blockquote> </div> </div></div> </div> </div><div class="wrap white " id="curated-cancer-pubs" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="mb-60 a-center"><h2>Curated <em class="blue">cancer research</em> publications</h2> </div> </div><div id="publications" class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"> <div class="wpdt-c wdt-skin-light"> <input type="hidden" id="table_2_desc" 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<div class="wdt-table-loader-row"> <div class="wdt-table-loader-cell wdt-animated-background"></div> <div class="wdt-table-loader-cell wdt-animated-background"></div> <div class="wdt-table-loader-cell wdt-animated-background"></div> </div> <div class="wdt-table-loader-row"> <div class="wdt-table-loader-cell wdt-animated-background"></div> <div class="wdt-table-loader-cell wdt-animated-background"></div> <div class="wdt-table-loader-cell wdt-animated-background"></div> </div> <div class="wdt-table-loader-row"> <div class="wdt-table-loader-cell wdt-animated-background"></div> <div class="wdt-table-loader-cell wdt-animated-background"></div> <div class="wdt-table-loader-cell wdt-animated-background"></div> </div> </div> </div><!-- /Table body --> <tr id="table_20_row_0" data-row-index="0"> <td style="">High-Multiplex Aptamer-Based Serum Proteomics to Identify Candidate Serum Biomarkers of Oral Squamous Cell Carcinoma</td> <td style="">Blatt, Sebastian et al.</td> <td style="">2023</td> <td style="">Cancers</td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style="">Seastian Blatt, Peer W. Kammerer, Maximilian Kruger, Rambabu Surabattula, Daniel G. E. Thiem, Simon T. Dillon, Bilal Al-Nawas, Towia A. Libermann, Detlef Schuppan</td> <td style=""><a href='https://www.mdpi.com/2072-6694/15/7/2071' rel='' target='_blank'><button class='SL-btn'>Learn more</button></a></td> <td style=""></td> </tr> <tr id="table_20_row_1" data-row-index="1"> <td style="">Glioblastoma survival is associated with distinct proteomic alteration signatures post chemoirradiation in a large-scale proteomic panel</td> <td style="">Krauze A V, et al.</td> <td style="">2023</td> <td style="">Front Oncol</td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""><a href='https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1127645/full' rel='' target='_blank'><button class='SL-btn'>Learn more</button></a></td> <td style=""></td> </tr> <tr id="table_20_row_2" data-row-index="2"> <td style="">Plasma proteome of growing tumors</td> <td style="">Gupta, Shashi</td> <td style="">2023</td> <td style="">Scientific Reports</td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""><a href='https://www.nature.com/articles/s41598-023-38079-9' rel='' target='_blank'><button class='SL-btn'>Learn more</button></a></td> <td style="">08/27/2023</td> </tr> <tr id="table_20_row_3" data-row-index="3"> <td style="">Associations between circulating proteins and risk of breast cancer by intrinsic subtypes: a Mendelian randomization analysis</td> <td style="">Shu X, et al.</td> <td style="">2022</td> <td style="">Br J Cancer</td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""><a href='https://pubmed.ncbi.nlm.nih.gov/35882941/' rel='' target='_blank'><button class='SL-btn'>Learn more</button></a></td> <td style=""></td> </tr> <tr id="table_20_row_4" data-row-index="4"> <td style="">Comprehensive apatamer-based screen of 1317 proteins uncovers improved stool protein markers of colorectal cancer</td> <td style="">Li H, et al.</td> <td style="">2021</td> <td style="">J Gastroenterol</td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""><a href='https://pubmed.ncbi.nlm.nih.gov/34117903/' rel='' target='_blank'><button class='SL-btn'>Learn more</button></a></td> <td style=""></td> </tr> <tr id="table_20_row_5" data-row-index="5"> <td style="">CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo</td> <td style="">Israel L, et al.</td> <td style="">2021</td> <td style="">Oncogenesis</td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""><a href='https://pubmed.ncbi.nlm.nih.gov/33824280/' rel='' target='_blank'><button class='SL-btn'>Learn more</button></a></td> <td style=""></td> </tr> <tr id="table_20_row_6" data-row-index="6"> <td style="">Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemia</td> <td style="">Celik H, et al.</td> <td style="">2020</td> <td style="">Blood Adv</td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""></td> <td style=""><a href='https://ashpublications.org/bloodadvances/article/4/2/367/440611/Highly-multiplexed-proteomic-assessment-of-human' rel='' target='_blank'><button class='SL-btn'>Learn more</button></a></td> <td style=""></td> </tr> </tbody> <!-- /Table body --> <!-- Table footer --> <!-- /Table footer --> </table> </div><style> table.wpDataTable { table-layout: fixed !important; } table.wpDataTable td, table.wpDataTable th { white-space: normal !important; } </style> <style> /* table font color */ 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<p><strong>References</strong></p> <ol> <li>Ghadermarzi S, <em>et al.</em> Sequence-derived markers of drug targets and potentially druggable human proteins. <em>Front Genet ID</em> (2019 ). doi:10.3389/fgene.2019.01075</li> </ol> </div> </div> </div> </div></div> </div> </div></main> <div class="modal video" id="modal-video"> <div class="modal-wrap"> <div class="modal-content"> <span class="modal-close"></span> <div class="modal-oembed"><script src="https://fast.wistia.com/assets/external/E-v1.js" async></script><div class="wistia_responsive_padding" style="padding:56.25% 0 0 0;position:relative;"><div class="wistia_responsive_wrapper" style="height:100%;left:0;position:absolute;top:0;width:100%;"><div class="wistia_embed wistia_async_n8oi7hv7qf dnt=1 seo=false videoFoam=true" style="height:100%;position:relative;width:100%"><div class="wistia_swatch" style="height:100%;left:0;opacity:0;overflow:hidden;position:absolute;top:0;transition:opacity 200ms;width:100%;"><img 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