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url(https://somalogic.com/wp-content/uploads/2022/07/Hero_Texture-5-scaled.jpeg);height: 768px;" title="Splash of teal and pink color"> <div class="container"> <div class="grid"> <div class="cell-md-9"> <p class="breadcrumbs"><a href="/">Home</a> / Products / Services / <span class="blue">SomaSignal tests</span></p> <h1>Powerful metrics provide multiple physiological assessments from a single sample</h1> <h2 class="blue">Now available using the SomaScan® 11K Assay</h2> <p>Obtain relevant data to advance your research.</p> </div> </div> </div> </div><div class="wrap grey statements" id="wrap_0" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><p style="font-size: 12px">SomaSignal Tests are for Research Use Only, and not to be used for diagnostic or patient medical management purposes. Looking for a diagnostic tool to guide patient medical treatment? <strong><a href="/clinical-test-menu">Learn about our LDT SSTs</a></strong>.</p> </div> </div></div> </div> </div><div class="wrap white " id="wrap_1" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><h2 style="margin-bottom: 30px">What are RUO SomaSignal® Tests?</h2> </div> </div><div class="cards-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0"> <div class=" cards no-margin" ><div class="card transparent owl-block" title=""> <div> <h3>For simple, straightforward clinical trial monitoring</h3> <div class="content"><ul class="blue-dot a-left"> <li>Simple blood test enables frequent sampling</li> <li>Does not require specialized physicians/pathologists</li> <li>Simple blood draw is ideal for longitudinal studies</li> </ul> </div> </div> </div><div class="card transparent owl-block" title=""> <div> <h3>Physiologically meaningful assessments</h3> <div class="content"><ul class="blue-dot a-left"> <li>21 SSTs provide multiple metrics from a single sample</li> <li>Relevant to cardiovascular disease, NASH, diabetes, and more</li> <li>Reporting current health state and understanding risk</li> </ul> </div> </div> </div><div class="card transparent owl-block" title=""> <div> <h3>Derived from just a 55-µL sample</h3> <div class="content"><ul class="blue-dot a-left"> <li>Simple and simultaneous sampling for all tests</li> <li>Derived from models based on proteomic signatures</li> <li>Validated against standard clinical measurement</li> </ul> </div> </div> </div></div> </div></div> </div> </div><div class="wrap black " id="wrap_2" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/07/C2_4_Texture-1-scaled.jpeg)" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><h2>See the technology</h2> </div> </div><div class="resources-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0"> <div class="owl-carousel cards " data-items="3"><div class="card owl-block blue resource-card" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/07/iStock-534831751-scaled-1.jpg);" title="iStock-534831751-scaled"> <div> <div class="content"> <h3><span>Webinar</span>Liquid health check – plasma protein patterns as comprehensive indicators of health</h3> Earlier this year, Stephen Williams (SomaLogic), Claudia Langenberg (University of Cambridge*), and Peter Ganz (UCSF) lead a team that demonstrated the first proof of concept for a comprehensive “liquid health check” that derived 11 different health indicators from 55µl of blood. The study combined clinical data from five different groups of nearly 17,000 prospectively monitored participants in whom ~5,000 proteins were measured at study baseline using the SomaScan® Assay. Using machine learning models, they found that they were able to characterize six current health states and predict three health related behaviors—equaling metrics that would typically be generated from a battery of costly medical tests and approximately nine visits to the doctor. Additionally, they used the proteomic data and their models to reliably forecast probabilities of cardiovascular events and advancement from prediabetes to diabetes five years later. In this webinar, Williams, Langenberg, and Ganz will discuss key findings and motivations for the study “Plasma protein patterns as comprehensive indicators of health,” which was recently published in Nature Medicine. The webinar will additionally explore the implications of their findings for public health, particularly in the areas of diabetes and cardiovascular disease. </div> <p class="a-center"><a href="https://somalogic.com/webinar/liquid-health-check/" class="btn white-border">Learn more</a></p> </div> </div><div class="card owl-block blue resource-card" style="background-image: url(https://somalogic.com/wp-content/uploads/2023/06/minnich_bms_june15_preview.jpg);" title="Image of human hands holding illustrated liver"> <div> <div class="content"> <h3><span>Webinar</span>Correlation of a nonalcoholic steatohepatitis proteomic test with clinical outcomes</h3> In this webinar, Anne Minnich, PhD, biomarker consultant at Bristol Myers Squibb, presents research on the use of the new SomaSignal(TM) NASH bundle test in a recently completed clinical trial. </div> <p class="a-center"><a href="https://somalogic.com/webinar/correlation-of-a-nonalcoholic-steatohepatitis-proteomic-test-with-clinical-outcomes/" class="btn white-border">Learn more</a></p> </div> </div><div class="card owl-block blue resource-card" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/07/man-mexican4.jpg);" title="Image of man smiling into camera"> <div> <div class="content"> <h3><span>Webinar</span>The liquid liver biopsy: characterizing NASH and NAFLD with serum protein biomarkers</h3> With SomaScan® Proteomics, predicting NASH and NAFLD is as simple as a blood test. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are increasingly common conditions that can progress to serious liver complications including cirrhosis and cancer. Diagnosing the severity of NAFLD and NASH has traditionally relied on invasive liver biopsies. It was recently demonstrated that the SomaScan Assay, a multiplex proteomics platform, can noninvasively and simultaneously predict all the key elements of the liver biopsy: liver fat, inflammation, hepatocyte ballooning and fibrosis based only on serum protein biomarkers. By measuring ~5000 proteins per sample in ~700 patients, with liver biopsy results, machine learning models were developed and validated that can reliably predict NAFLD/NASH phenotypes . The tests were used to characterize the differential mechanistic effects of three different drugs during clinical trials. In this webinar, Dr. Steve Williams, the Chief Medical Officer for SomaLogic, will present this work and introduce a soon to be launched NASH test that is available for research use only through the SomaScan Discovery Alliance. </div> <p class="a-center"><a href="https://somalogic.com/webinar/the-liquid-liver-biopsy-characterizing-nash-and-nafld-with-serum-protein-biomarkers/" class="btn white-border">Learn more</a></p> </div> </div><div class="card owl-block blue resource-card" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/07/iStock-1014817786-scaled-1.jpg);" title="Image of female looking into camera"> <div> <div class="content"> <h3><span>Webinar</span>Proteomics reveals the hidden impact of interventions in diabetes</h3> Type 2 diabetes typically manifests itself in adulthood, following years of progressively worsening health status, affecting multiple biological systems, pathways and organs. But beyond measuring HbA1c, it has been difficult and expensive to measure the impact of disease and/or interventions that might impact organ damage or risk. Large-scale proteomics is an emerging field that has recently been shown to not only capture real-time health status, but also to predict or prognose risks of future organ damage, morbidity and mortality. Proteomic models, developed from multiple large clinical and observational studies, have been utilized here to provide a holistic summary of metabolic health and risk of future adverse outcomes from individuals undergoing diabetes intervention. In this webcast, the impact of both therapeutic (drug) and lifestyle (diet and exercise) interventions will be discussed on a host of cardiometabolic and body composition measures in subjects undergoing intervention compared to placebo or standard of care. The speakers will discuss how these proteomic models can be implemented to design more precise treatment strategies for diabetic patients, moving the field ever closer to realizing the goal of providing personalized care. </div> <p class="a-center"><a href="https://somalogic.com/webinar/proteomics-reveals-the-hidden-impact-of-interventions-in-diabetes-webinar/" class="btn white-border">Learn more</a></p> </div> </div></div> </div></div> </div> </div><div class="wrap white " id="testsMenu" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><h2>What tests are <em class="blue">available </em>for research use?</h2> </div> </div><div class="cards-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0"> <div class=" cards cards-center" ><div class="card white owl-block" title="Body Fat Percentage Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/bodyFat_Percent126px.svg" alt="Body Fat Percentage Icon" /></p> <h3>Body fat %</h3> <div class="content"><p>Percent body fat</p> </div> </div> </div><div class="card white owl-block" title="Resting Energy Rate Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/restingBurn_126px.svg" alt="Resting Energy Rate Icon" /></p> <h3>Resting energy expenditure</h3> <div class="content"><p>Calories burned at rest</p> </div> </div> </div><div class="card white owl-block" title="Lean Body Mass Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/leanBodyMass_126px.svg" alt="Lean Body Mass Icon" /></p> <h3>Lean body mass</h3> <div class="content"><p>Total lean body mass</p> </div> </div> </div><div class="card white owl-block" title="Glucose - Diabetes Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/glucose_Diabetes_126px.svg" alt="Glucose - Diabetes Icon" /></p> <h3>Glucose tolerance</h3> <div class="content"><p>Blood glucose levels following sugar intake</p> </div> </div> </div><div class="card white owl-block" title="Liver Fat Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/liverFat_126px.svg" alt="Liver Fat Icon" /></p> <h3>Liver fat</h3> <div class="content"><p>Presence/absence of excess liver fat</p> </div> </div> </div><div class="card white owl-block" title="Visceral Fat Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/VisceralFat_126px.svg" alt="Visceral Fat Icon" /></p> <h3>Visceral fat</h3> <div class="content"><p>Fat content around vital organs</p> </div> </div> </div><div class="card white owl-block" title="Primary Cardiovascular Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/cvd_1_126px.svg" alt="Primary Cardiovascular Icon" /></p> <h3>CVD primary</h3> <div class="content"><p>4-year risk of heart attack, stroke, or heart failure</p> </div> </div> </div><div class="card white owl-block" title="Residual Cardiovascular Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/cvd_2_126px.svg" alt="Residual Cardiovascular Icon" /></p> <h3>CVD secondary</h3> <div class="content"><p>4-year risk of heart attack, stroke, or heart failure following an initial event</p> </div> </div> </div><div class="card white owl-block" title="Lungs VO2 Max Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/lungs_VO2_126px.svg" alt="Lungs VO2 Max Icon" /></p> <h3>Cardiorespiratory fitness</h3> <div class="content"><p>Aerobic fitness level (VO2 max)</p> </div> </div> </div><div class="card white owl-block" title="Alcohol Liver Impact Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/alcoholConsumption.svg" alt="Alcohol Liver Impact Icon" /></p> <h3>Alcohol impact</h3> <div class="content"><p>Predicted weekly alcohol consumption</p> </div> </div> </div><div class="card white owl-block" title="Illustration of Steatosis"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/NASH-Steatosis.svg" alt="Illustration of Steatosis" /></p> <h3>NASH: steatosis</h3> <div class="content"><p>Measures NASH-related liver steatosis</p> </div> </div> </div><div class="card white owl-block" title="Illustration of NASH Inflammation"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/NASH-Inflammation.svg" alt="Illustration of NASH Inflammation" /></p> <h3>NASH: inflammation</h3> <div class="content"><p>Measures NASH-related liver inflammation</p> </div> </div> </div><div class="card white owl-block" title="Illustration of NASH - Fibrosis"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/NASH-Fibrosis.svg" alt="Illustration of NASH - Fibrosis" /></p> <h3>NASH: Fibrosis</h3> <div class="content"><p>Measures NASH-related Liver Fibrosis</p> </div> </div> </div><div class="card white owl-block" title="Illustration of NASH - Ballooning"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/NASH-Ballooning.svg" alt="Illustration of NASH - Ballooning" /></p> <h3>NASH: ballooning</h3> <div class="content"><p>Measures NASH-related liver ballooning</p> </div> </div> </div><div class="card white owl-block" title="Heart Failure Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/heartFailure_126px.svg" alt="Heart Failure Icon" /></p> <h3>Heart Failure reduced Ejection Fraction: 6 months</h3> <div class="content"><p>Risk of death in 6 months with stable HFrEF</p> </div> </div> </div><div class="card white owl-block" title="Heart Failure Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/heartFailure_126px.svg" alt="Heart Failure Icon" /></p> <h3>Heart Failure reduced Ejection Fraction: 12 months</h3> <div class="content"><p>Risk of death in 1 year with stable HFrEF</p> </div> </div> </div><div class="card white owl-block" title="Heart Failure Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/heartFailure_126px.svg" alt="Heart Failure Icon" /></p> <h3>Heart Failure preserved Ejection Fraction: 6 months</h3> <div class="content"><p>Risk of death in 6 months with stable HFpEF</p> </div> </div> </div><div class="card white owl-block" title="Heart Failure Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/heartFailure_126px.svg" alt="Heart Failure Icon" /></p> <h3>Heart Failure preserved Ejection Fraction: 12 months</h3> <div class="content"><p>Risk of death in 1 year with stable HFpEF</p> </div> </div> </div><div class="card white owl-block" title="Lung Prognosis Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/lungPrognosis_126px.svg" alt="Lung Prognosis Icon" /></p> <h3>Kidney prognosis</h3> <div class="content"><p>Risk of worsening Chronic Kidney Disease</p> </div> </div> </div><div class="card white owl-block" title="Dementia Risk Icon"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/dementia_126px.svg" alt="Dementia Risk Icon" /></p> <h3>Dementia risk</h3> <div class="content"><p>Risk of Dementia diagnosis within 20 years</p> </div> </div> </div><div class="card white owl-block" title="Illustration of clock with fork and spoon, symbolizing fasting"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2024/01/FedFasted.svg" alt="Illustration of clock with fork and spoon, symbolizing fasting" /></p> <h3>Fed-fasted</h3> <div class="content"><p>Hours since last meal</p> </div> </div> </div></div> </div><div class="text-block cell-md-10 cell-offset-md-1 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><h2 class="mt-60">How were they <em class="blue">developed</em>?</h2> <p>SomaSignal Tests are developed by analyzing thousands of proteins in thousands of patients using the SomaScan Assay. Protein signatures revealed by the SomaScan Assay are compared against standard clinical measurements in order to identify patterns of protein changes that correlate with current health status and future trajectory using machine learning. Each pattern becomes the basis for a specific SomaSignal Test. Because each SomaSignal Test is generated using a subset of the 11,000 proteins measured by the SomaScan Assay, results for all of the SomaSignal Tests can be derived from a single 55-µL blood sample.</p> <p class="mt-60"><img decoding="async" class="aligncenter size-full wp-image-9185" src="https://somalogic.com/wp-content/uploads/2024/10/testsDiagram.png" alt="SomaSignal Tests Diagram" width="1000" height="425" srcset="https://somalogic.com/wp-content/uploads/2024/10/testsDiagram.png 1000w, https://somalogic.com/wp-content/uploads/2024/10/testsDiagram-300x128.png 300w, https://somalogic.com/wp-content/uploads/2024/10/testsDiagram-768x326.png 768w" sizes="(max-width: 1000px) 100vw, 1000px" /></p> </div> </div></div> </div> </div><div class="wrap black " id="wrap_4" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/07/C2_4_CTA-Texture-1-scaled.jpeg)" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><h2>See relevant publications in our interactive viewer</h2> <p><a class="btn blue" href="/publications">Review publications</a></p> </div> </div></div> </div> </div><div class="wrap white " id="sign-up" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><p><a class="btn blue" href="https://share.hsforms.com/1u2UcnYKdT6O5S0sh13kPdg3zbc6" target="_blank" rel="noopener">Connect with our sales team</a></p> </div> </div></div> </div> </div></main> <footer> <div class="footer-top"> <div class="container"> <div class="grid"> <div class="cell-md-6"> <img src="https://somalogic.com/wp-content/themes/soma/img/SomaLogic-SBI-Dual-Logo-White.svg" alt="Somalogic logo" class="footer-logo" /> <p>SomaLogic Operating Co., Inc.<br /> 2945 Wilderness Pl. 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