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International Journal of Biological Sciences
<!DOCTYPE html> <html lang="en"><head> <meta charset="utf-8"> <title>International Journal of Biological Sciences</title><meta name="keywords" content="biology, journal, genetics, biochemistry" > <meta name="description" content="International peer-reviewed journal publishes multidisciplinary research papers in general biology, biochemistry, genetics, biotechnology and related areas." > <meta name="viewport" content="width=device-width, initial-scale=1" > <link rel="stylesheet" type="text/css" media="all" href="/ms/css/ivy.css?v=82"> <link rel="stylesheet" type="text/css" media="all and (min-width: 801px)" href="/ms/site/mainnew.css?v=15"> <link rel="stylesheet" type="text/css" media="all and (min-width: 801px)" href="/style.css?v=38"> <link rel="stylesheet" type="text/css" media="all and (max-width: 800px)" href="/ms/css/ivymobile.css?v=34" > <link rel="stylesheet" type="text/css" media="all and (max-width: 800px)" href="/ms/site/sitemobile.css?v=2" > <script src="/ms/java/function.js?v=43"></script> </head> <body id="main_body"> <div id="page_all"> <div id="container"> <div id="header"> <div id="logo" > <div > <span class='ivyjournal display_mobile'>International Journal of Biological Sciences</span> </div> </div> <div id="key_visual"> <span class='button_grey impactfactor'>Impact factor<br>8.2</span><span class='display_pc' > <br><br><br><br></span> <span class='textlinkgrey display_pc' >ISSN: 1449-2288</span></div> </div> <div id="main_nav_container"> <ul id=main_nav_list><li><a href="/" >Home </a></li><li><a href="/ms/author" >For Authors </a></li><li><a href="/ms/submit" >Submit Manuscript </a></li><li><a href="/ms/status" >Login </a></li><li><a href="/ms/feedback" >Contact </a></li></ul> <div class='topnav-right'> <a href='/ms/userlogin' title='My account'><img src='/ms/images/account.svg' alt='Account' height='24' width='24'> </a> </div> </div> <div id="main_container"> <div id="sub_container1"> <div id="sub_nav_container"> <ul class='sub_nav_list'><li><a href="/currentissue" >Current Issue </a></li><li><a href="/ms/archive/21" >Volume 21; 2025 </a></li><li><a href="/ms/archive/20" >Volume 20; 2024 </a></li><li><a href="/ms/archive/19" >Volume 19; 2023 </a></li><li><a href="/ms/archive/18" >Volume 18; 2022 </a></li><li><a href="/ms/archive/17" >Volume 17; 2021 </a></li><li><a href="/ms/archive" >Archive </a></li><li><a href="/ms/acceptms" >Advance Articles </a></li><li><a href="/editorial" >Editorial Board </a></li><li><a href="/ms/coverimage" >Cover Images </a></li><li><a href="/coverage" >Index & Coverage </a></li><li><a href="/ms/coversuggest" >Cover Suggestion </a></li><li><a href="/specialissue" >Special Issues </a></li></ul> <form method="post" action="/ms/mysearch" class="searchblock" > <input type="text" name="query" size="9" maxlength="255" value="" id="sbi" class="formfield" placeholder="Article title/doi"> <button type="submit" name="search" value="Search" id="sbb" title="Search article by title or doi"><img src='/ms/images/search.svg' alt='Search' height='24' width='24' style='vertical-align: middle;'></button> <input type="hidden" name="content" value="IJBS1449-2288"> </form> <div class='sub_nav_space display_pc'></div> <div class="imagecenter"> <p class="divboxbg"><a href="https://www.thno.org" class="textlink">Theranostics</a></p> <p class="divboxbg"><a href="https://www.medsci.org" class="textlink">International Journal of Medical Sciences</a></p> <p class="divboxbg"><a href="https://www.ntno.org" class="textlink">Nanotheranostics</a></p> <p class="divboxbg"><a href="https://www.jcancer.org" class="textlink">Journal of Cancer</a></p> <p class="divboxbg"><a href="https://www.jgenomics.com" class="textlink">Journal of Genomics</a></p> <a href="https://www.ncbi.nlm.nih.gov/pmc/journals/294/" ><img src="/ms/images/pmclogo.gif" alt="PubMed Central" width="145" height="75" class="imagecenter" ></a> <p class="divboxbg abstract"> <img src="/ms/images/openaccess.jpg" width="145" height="54" alt="open access"> Global reach, higher impact</p> </div> </div> </div> <div id="sub_container2"> <!-- ContentIvyspring --> <div class="flex-container"> <div id="contentcolumn"> <img width='350' height='178' class='clickfig' src='/v21/p2647/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p2647/toc.jpg');"> <p> Review<br> <a class='linkSameColor' href='/v21p2647.htm'><b>Conception and Concern: A Review of Breast Cancer Risk in Assisted Reproductive Technology</b></a> <br> Zijie Guo, Ziyu Zhu, Xixi Lin, Kevin Matthew Zhang, Qingliang Wu, Shenkangle Wang, Mingpeng Luo, Xiaona Lin, Linbo Wang, Jichun Zhou<br> <i>Int. J. Biol. Sci.</i> 2025; 21(6): 2647-2671. doi:10.7150/ijbs.105357 <br> <a class='boxtext' href='/v21p2647.htm'>Full text</a> <a class='boxtext' href='/v21p2647.pdf'>PDF</a> </p> <hr class='clear'><img width='350' height='175' class='clickfig' src='/v21/p2629/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p2629/toc.jpg');"> <p> Research Paper<br> <a class='linkSameColor' href='/v21p2629.htm'><b>EMC2 promotes breast cancer progression and enhances sensitivity to PDK1/AKT inhibition by deubiquitinating ENO1</b></a> <br> Shihan Xiao, Shangxuan Jiang, Chengxu Wen, Han Wang, Wenxiang Nie, Jianguo Zhao, Bo Zhang<br> <i>Int. J. Biol. Sci.</i> 2025; 21(6): 2629-2646. doi:10.7150/ijbs.109192 <br> <a class='boxtext' href='/v21p2629.htm'>Full text</a> <a class='boxtext' href='/v21p2629.pdf'>PDF</a> </p> <hr class='clear'><img width='350' height='238' class='clickfig' src='/v21/p2606/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p2606/toc.jpg');"> <p> Review<br> <a class='linkSameColor' href='/v21p2606.htm'><b>Unraveling the breast cancer tumor microenvironment: crucial factors influencing natural killer cell function and therapeutic strategies</b></a> <br> Feifei Li, Chunfang Gao, Yan Huang, Yu Qiao, Hongxiao Xu, Sheng Liu, Huangan Wu<br> <i>Int. J. Biol. Sci.</i> 2025; 21(6): 2606-2628. doi:10.7150/ijbs.108803 <br> <a class='boxtext' href='/v21p2606.htm'>Full text</a> <a class='boxtext' href='/v21p2606.pdf'>PDF</a> </p> <hr class='clear'><img width='350' height='240' class='clickfig' src='/v21/p2589/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p2589/toc.jpg');"> <p> Review<br> <a class='linkSameColor' href='/v21p2589.htm'><b>Targeting Glycolysis for Treatment of Breast Cancer Resistance: Current Progress and Future Prospects</b></a> <br> Zixu Niu, Jing He, Siyuan Wang, Bingjian Xue, Hao Zhang, Ruohan Hou, Zimeng Xu, Jing Sun, Fucheng He, Xinhong Pei<br> <i>Int. J. Biol. Sci.</i> 2025; 21(6): 2589-2605. doi:10.7150/ijbs.109803 <br> <a class='boxtext' href='/v21p2589.htm'>Full text</a> <a class='boxtext' href='/v21p2589.pdf'>PDF</a> </p> <hr class='clear'><img width='350' height='227' class='clickfig' src='/v21/p2568/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p2568/toc.jpg');"> <p> Research Paper<br> <a class='linkSameColor' href='/v21p2568.htm'><b>Cgref1 is a CREB-H-regulated hepatokine that promotes hepatic <i>de novo</i> lipogenesis by mediating epididymal fat insulin resistance</b></a> <br> Pearl Chan, Pak-Hin Hinson Cheung, Xiao-Zhuo Kang, Yun Cheng, Chi-Ming Wong, Dong-Yan Jin, Chi-Ping Chan<br> <i>Int. J. Biol. Sci.</i> 2025; 21(6): 2568-2588. doi:10.7150/ijbs.97008 <br> <a class='boxtext' href='/v21p2568.htm'>Full text</a> <a class='boxtext' href='/v21p2568.pdf'>PDF</a> </p> <hr class='clear'><img width='350' height='131' class='clickfig' src='/v21/p2550/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p2550/toc.jpg');"> <p> Research Paper<br> <a class='linkSameColor' href='/v21p2550.htm'><b>Targeting HCG18 counteracts ferroptosis resistance via blocking the miR-30a-5p/RRM2/GSS pathway in hepatocellular carcinoma</b></a> <br> Tian Zhan, Yawei Liu, Shuoke Duan, Chen Lu, Heng Jia, Ming Jin, Jie Li, Xinru Du, Sizheng Sun, Yuan Li, Jianping Zhang<br> <i>Int. J. Biol. Sci.</i> 2025; 21(6): 2550-2567. doi:10.7150/ijbs.104127 <br> <a class='boxtext' href='/v21p2550.htm'>Full text</a> <a class='boxtext' href='/v21p2550.pdf'>PDF</a> </p> <p><a href="/ms/archive">More ...</a></p> </div> <div id="rightcolumn" > <div class='rightbox'> <a href='/v21i4'><div class='cursor-pointer coverfig' ><img src='cover/thumb/v21i4.jpg' alt='Cover image' ></div></a> <p> Editor-in-Chief: <strong>Chuxia Deng</strong>, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau<br> <br> <a href="eic_profile.php"> Editor-in-Chief's Profile</a> </p> <hr class='nice'> <ul class="ilist"> <li>Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (<a href="coverage">full index information</a>) </li> <li>Full texts of articles in <a href="https://www.ncbi.nlm.nih.gov/pmc/journals/294/">PubMed Central</a> and <a href="https://europepmc.org/journals/781/">Europe PMC</a>.</li> </ul> <hr class='nice'> <ul class="ilist"> <li>🆘<a href="/v18i12">2022 the 3rd Special issue of COVID-19</a></li> <li>🆘<a href="https://www.ijbs.com/v17i6">2021 the 2nd Special issue of COVID-19 </a></li> <li><strong>🆘</strong><a href="https://www.ijbs.com/v16i10">2020 the 1st Special issue of COVID-19</a></li> </ul> <hr class='nice'> Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau <a href="/item/postdocdeng.html">...full details</a> <hr class='nice'> Journal of Genomics articles:<br> <p> Research Paper<br> <a class='linkSameColor' href='https://www.jgenomics.com/v13p0024.htm'><b>Dexamethasone-Induced MerTK<sup>+/high</sup> M2c Macrophages Exhibit a Preference for Downregulated Gene Expression Profiles</b></a> <br> Zhen-Tao Lee, Farrah Putri Salmanida, Hso-Chi Chaung, Ko-Tung Chang<br> <i>J. Genomics</i> 2025; 13: 24-39. <br> <a class='boxtext abstract' href='https://www.jgenomics.com/v13p0024.htm'>Full text</a> <a class='boxtext abstract' href='https://www.jgenomics.com/v13p0024.pdf'>PDF</a> </p> </div> </div> </div> <!-- Popup image --> <div id="popupFig" class="popupFig cursor-zoom-out"> <div id="popupFig-wrap" class="popupFig-wrap"> <img id="popupFigImage" src="" class="clickfig_max" alt="Popup Image" onclick="closePopupFig()"> </div> </div> <!-- ContentIvyspringEnd --> </div> <div id="footer_text"><hr class="nice"> <p>©2025 <a href="https://ivyspring.com" >Ivyspring International Publisher</a>. <a href="/ms/terms">Terms of use</a></p></div> </div> </div> </div> </body></html>