CINXE.COM

<!DOCTYPE html> <html lang="en"><head> <meta charset="utf-8"> <title>Volume 18, Issue 12 - ijbs</title> <meta name="viewport" content="width=device-width, initial-scale=1" > <link rel="stylesheet" type="text/css" media="all" href="/ms/css/ivy.css?v=82"> <link rel="stylesheet" type="text/css" media="all and (min-width: 801px)" href="/ms/site/mainnew.css?v=15"> <link rel="stylesheet" type="text/css" media="all and (min-width: 801px)" href="/style.css?v=38"> <link rel="stylesheet" type="text/css" media="all and (max-width: 800px)" href="/ms/css/ivymobile.css?v=34" > <link rel="stylesheet" type="text/css" media="all and (max-width: 800px)" href="/ms/site/sitemobile.css?v=2" > <script src="/ms/java/function.js?v=43"></script> </head> <body id="main_body"> <div id="page_all"> <div id="container"> <div id="header"> <div id="logo" > <div > <span class='ivyjournal display_mobile'>International Journal of Biological Sciences</span>  </div> </div> <div id="key_visual"> <span class='button_grey impactfactor'>Impact factor<br>8.2</span><span class='display_pc' > <br><br><br><br></span> <span class='textlinkgrey display_pc' >ISSN: 1449-2288</span></div> </div> <div id="main_nav_container"> <ul id=main_nav_list><li><a href="/" >Home </a></li><li><a href="/ms/author" >For Authors </a></li><li><a href="/ms/submit" >Submit Manuscript </a></li><li><a href="/ms/status" >Login </a></li><li><a href="/ms/feedback" >Contact </a></li></ul> <div class='topnav-right'> <a href='/ms/userlogin' title='My account'><img src='/ms/images/account.svg' alt='Account' height='24' width='24'> </a> </div> </div> <div id="main_container"> <div id="sub_container1"> <div id="sub_nav_container"> <ul class='sub_nav_list'><li><a href="/currentissue" >Current Issue </a></li><li><a href="/ms/archive/21" >Volume 21; 2025 </a></li><li><a href="/ms/archive/20" >Volume 20; 2024 </a></li><li><a href="/ms/archive/19" >Volume 19; 2023 </a></li><li><a href="/ms/archive/18" >Volume 18; 2022 </a></li><li><a href="/ms/archive/17" >Volume 17; 2021 </a></li><li><a href="/ms/archive" >Archive </a></li><li><a href="/ms/acceptms" >Advance Articles </a></li><li><a href="/editorial" >Editorial Board </a></li><li><a href="/ms/coverimage" >Cover Images </a></li><li><a href="/coverage" >Index & Coverage </a></li><li><a href="/ms/coversuggest" >Cover Suggestion </a></li><li><a href="/specialissue" >Special Issues </a></li></ul> <form method="post" action="/ms/mysearch" class="searchblock" > <input type="text" name="query" size="9" maxlength="255" value="" id="sbi" class="formfield" placeholder="Article title/doi"> <button type="submit" name="search" value="Search" id="sbb" title="Search article by title or doi"><img src='/ms/images/search.svg' alt='Search' height='24' width='24' style='vertical-align: middle;'></button> <input type="hidden" name="content" value="IJBS1449-2288"> </form> <div class='sub_nav_space display_pc'></div> <div class="imagecenter"> <p class="divboxbg"><a href="https://www.thno.org" class="textlink">Theranostics</a></p> <p class="divboxbg"><a href="https://www.medsci.org" class="textlink">International Journal of Medical Sciences</a></p> <p class="divboxbg"><a href="https://www.ntno.org" class="textlink">Nanotheranostics</a></p> <p class="divboxbg"><a href="https://www.jcancer.org" class="textlink">Journal of Cancer</a></p> <p class="divboxbg"><a href="https://www.jgenomics.com" class="textlink">Journal of Genomics</a></p> <a href="https://www.ncbi.nlm.nih.gov/pmc/journals/294/" ><img src="/ms/images/pmclogo.gif" alt="PubMed Central" width="145" height="75" class="imagecenter" ></a> <p class="divboxbg abstract"> <img src="/ms/images/openaccess.jpg" width="145" height="54" alt="open access"> Global reach, higher impact</p> </div> </div> </div> <div id="sub_container2">  <div class='coverfig imageright' ><img src='cover/thumb/v18i12.jpg' alt='Front cover' onclick="openPopupFig('cover/v18i12.jpg');"> </div><p > <a class="boxnice" href="v18i11">◂ Last issue</a> <a class="boxnice" href="v18i13">Next issue ▸</a> <a class="boxnice" href="/ms/archive">Archive</a> <a class="boxnice" href="cover/v18i12.pdf">Cover PDF</a>   </p><p class="tocheading" style='clear:right;' >Volume 18 (12); 2022</p><p class='articlegroup' style='clear:right;' >Editorial</p><p><b>The global battle against SARS-CoV-2 and COVID-19 at the third year</b> <br> Chu-Xia Deng <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4792-4794. doi:10.7150/ijbs.76035 <br> <a class="boxtext" href="/v18p4792.htm">Full text</a> <a class="boxtext" href="/v18p4792.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874949">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305272/">PMC</a></p><p class='articlegroup' style='clear:right;' >Research Papers</p><img class='clickfig' src='/v18/p4618/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4618/toc.jpg');"> <p><b>Effect of a Functional Phospholipid Metabolome-Protein Association Pathway on the Mechanism of COVID-19 Disease Progression</b> <br> Mingshan Xue, Teng Zhang, Zhangkai J. Cheng, Baojun Guo, Yifeng Zeng, Runpei Lin, Peiyan Zheng, Mingtao Liu, Fengyu Hu, Feng Li, Wensheng Zhang, Lu Li, Qi Zhao, Baoqing Sun, Xiaoping Tang <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4618-4628. doi:10.7150/ijbs.72450 <br> <a class="boxtext" href="/v18p4618.htm">Full text</a> <a class="boxtext" href="/v18p4618.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874944">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305269/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4648/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4648/toc.jpg');"> <p><b>Dysregulation of Innate and Adaptive Immune Responses in Asymptomatic SARS-CoV-2 Infection with Delayed Viral Clearance</b> <br> Shanshan Cao, Qing Zhang, Liu Song, Mingzhong Xiao, Yexing Chen, Dianbing Wang, Min Li, Jinchao Hu, Lin Lin, Ying Zheng, Kun Zhou, Shujian Ye, Juan Zhou, Ya Na Zhou, Jing Cui, Jingzhi Wang, Jing Sun, Junxiu Tao, Zhou Chen, Rong Chen, Peng Zhou, Zhengli Shi, Sheng Wei, Linhua Zhao, Hui Wang, Xiaoling Tong, Xiaodong Li, Dong Men, Baidong Hou, Xian-En Zhang <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4648-4657. doi:10.7150/ijbs.72963 <br> <a class="boxtext" href="/v18p4648.htm">Full text</a> <a class="boxtext" href="/v18p4648.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874943">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305270/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4658/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4658/toc.jpg');"> <p><b>Structural basis of SARS-CoV-2 and its variants binding to intermediate horseshoe bat ACE2</b> <br> Lingfeng Tang, Di Zhang, Pu Han, Xinrui Kang, Anqi Zheng, Zepeng Xu, Xin Zhao, Vivien Ya-Fan Wang, Jianxun Qi, Qihui Wang, Kefang Liu, George F. Gao <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4658-4668. doi:10.7150/ijbs.73640 <br> <a class="boxtext" href="/v18p4658.htm">Full text</a> <a class="boxtext" href="/v18p4658.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874946">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305271/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4677/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4677/toc.jpg');"> <p><b>Prospects of Coffee Leaf against SARS-CoV-2 Infection</b> <br> Chen-Shiou Wu, Hsiu-Mei Chiang, Yeh Chen, Chung-Yu Chen, Hsiao-Fan Chen, Wen-Chi Su, Wei-Jan Wang, Yu-Chi Chou, Wei-Chao Chang, Shao-Chun Wang, Mien-Chie Hung <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4677-4689. doi:10.7150/ijbs.76058 <br> <a class="boxtext" href="/v18p4677.htm">Full text</a> <a class="boxtext" href="/v18p4677.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874948">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305275/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4714/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4714/toc.jpg');"> <p><b>Targeting ACLY efficiently inhibits SARS-CoV-2 replication</b> <br> Terrence Tsz-Tai Yuen, Jasper Fuk-Woo Chan, Bingpeng Yan, Cynthia Cheuk-Ying Shum, Yuanchen Liu, Huiping Shuai, Yuxin Hou, Xiner Huang, Bingjie Hu, Yue Chai, Chaemin Yoon, Tianrenzheng Zhu, Huan Liu, Jialu Shi, Jinjin Zhang, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Feifei Yin, Shuofeng Yuan, Bao-Zhong Zhang, Hin Chu <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4714-4730. doi:10.7150/ijbs.72709 <br> <a class="boxtext" href="/v18p4714.htm">Full text</a> <a class="boxtext" href="/v18p4714.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874959">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305265/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4744/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4744/toc.jpg');"> <p><b>Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway</b> <br> Bingpeng Yan, Shuofeng Yuan, Jianli Cao, Kingchun Fung, Pok-Man Lai, Feifei Yin, Kong-Hung Sze, Zhenzhi Qin, Yubin Xie, Zi-Wei Ye, Terrence Tsz-Tai Yuen, Kenn Ka-Heng Chik, Jessica Oi-Ling Tsang, Zijiao Zou, Chris Chun-Yiu Chan, Cuiting Luo, Jian-Piao Cai, Kwok-Hung Chan, Tom Wai-Hing Chung, Anthony Raymond Tam, Hin Chu, Dong-Yan Jin, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Richard Yi-Tsun Kao, Jasper Fuk-Woo Chan <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4744-4755. doi:10.7150/ijbs.73057 <br> <a class="boxtext" href="/v18p4744.htm">Full text</a> <a class="boxtext" href="/v18p4744.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874954">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305268/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4781/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4781/toc.jpg');"> <p><b>Cross-variant protection against SARS-CoV-2 infection in hamsters immunized with monovalent and bivalent inactivated vaccines</b> <br> Zi-Wei Ye, Yilan Fan, Kaiming Tang, Chon Phin Ong, Cuiting Luo, Hon-Lam Chung, Tsun-Lam Leong, Ronghui Liang, Wai-Yin Lui, Runhong Zhou, Yun Cheng, Lu Lu, Pak-Hin Hinson Cheung, Jasper Fuk-Woo Chan, Zhiwei Chen, Kwok-Yung Yuen, Shuofeng Yuan, Kelvin Kai-Wang To, Dong-Yan Jin <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4781-4791. doi:10.7150/ijbs.72109 <br> <a class="boxtext" href="/v18p4781.htm">Full text</a> <a class="boxtext" href="/v18p4781.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874942">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305277/">PMC</a></p><p class='articlegroup' style='clear:right;' >Reviews</p><img class='clickfig' src='/v18/p4610/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4610/toc.jpg');"> <p><b>The significance of advanced COVID-19 diagnostic testing in pandemic control measures</b> <br> Hang Fai Kwok <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4610-4617. doi:10.7150/ijbs.72837 <br> <a class="boxtext" href="/v18p4610.htm">Full text</a> <a class="boxtext" href="/v18p4610.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874951">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305263/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4629/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4629/toc.jpg');"> <p><b>Humoral and Cellular Immune Responses of COVID-19 vaccines against SARS-Cov-2 Omicron variant: a systemic review</b> <br> Zhonghao Chen, Ying Zhang, Meng Wang, Md Sahidul Islam, Ping Liao, Yuanjia Hu, Xin Chen <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4629-4641. doi:10.7150/ijbs.73583 <br> <a class="boxtext" href="/v18p4629.htm">Full text</a> <a class="boxtext" href="/v18p4629.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874952">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305266/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4642/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4642/toc.jpg');"> <p><b>Recipients of COVID-19 vaccines face challenges of SARS-CoV-2 variants</b> <br> Tianhong Li, Kathy Qian Luo <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4642-4647. doi:10.7150/ijbs.72424 <br> <a class="boxtext" href="/v18p4642.htm">Full text</a> <a class="boxtext" href="/v18p4642.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874950">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305267/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4669/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4669/toc.jpg');"> <p><b>Natural tannins as anti-SARS-CoV-2 compounds</b> <br> Shao-Chun Wang, I-Wen Chou, Mien-Chie Hung <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4669-4676. doi:10.7150/ijbs.74676 <br> <a class="boxtext" href="/v18p4669.htm">Full text</a> <a class="boxtext" href="/v18p4669.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874955">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305278/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4690/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4690/toc.jpg');"> <p><b>Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19</b> <br> Weifeng He, Yuan Gao, Jing Zhou, Yi Shi, Dajing Xia, Han-Ming Shen <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4690-4703. doi:10.7150/ijbs.72544 <br> <a class="boxtext" href="/v18p4690.htm">Full text</a> <a class="boxtext" href="/v18p4690.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874956">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305279/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4704/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4704/toc.jpg');"> <p><b>Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation</b> <br> Wenbiao Wang, Junzhe Chen, Xueqing Yu, Hui-Yao Lan <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4704-4713. doi:10.7150/ijbs.72663 <br> <a class="boxtext" href="/v18p4704.htm">Full text</a> <a class="boxtext" href="/v18p4704.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874957">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305276/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4731/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4731/toc.jpg');"> <p><b>SARS-CoV-2 and the Nucleus</b> <br> Mengqi Chen, Yue Ma, Wakam Chang <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4731-4743. doi:10.7150/ijbs.72482 <br> <a class="boxtext" href="/v18p4731.htm">Full text</a> <a class="boxtext" href="/v18p4731.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874947">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305274/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4756/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4756/toc.jpg');"> <p><b>COVID-19 Pandemic: Insights into Interactions between SARS-CoV-2 Infection and MAFLD</b> <br> Hanfei Chen, Qiang Chen <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4756-4767. doi:10.7150/ijbs.72461 <br> <a class="boxtext" href="/v18p4756.htm">Full text</a> <a class="boxtext" href="/v18p4756.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874945">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305262/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4768/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4768/toc.jpg');"> <p><b>Long COVID and its Management</b> <br> Ho Cheng Koc, Jing Xiao, Weiwei Liu, Yong Li, Guokai Chen <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4768-4780. doi:10.7150/ijbs.75056 <br> <a class="boxtext" href="/v18p4768.htm">Full text</a> <a class="boxtext" href="/v18p4768.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874958">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305273/">PMC</a></p><hr class='clear'><img class='clickfig' src='/v18/p4795/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v18/p4795/toc.jpg');"> <p><b>Revealing the mystery of persistent smell loss in long COVID patients</b> <br> Jung Woo Park, Xiaoyan Wang, Ren-He Xu <br> <i>Int. J. Biol. Sci.</i> 2022; 18(12): 4795-4808. doi:10.7150/ijbs.73485 <br> <a class="boxtext" href="/v18p4795.htm">Full text</a> <a class="boxtext" href="/v18p4795.pdf">PDF</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pubmed/35874953">PubMed</a> <a class="boxtext" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305264/">PMC</a></p>  <div id="popupFig" class="popupFig cursor-zoom-out"> <div id="popupFig-wrap" class="popupFig-wrap"> <img id="popupFigImage" src="" class="clickfig_max" alt="Popup Image" onclick="closePopupFig()"> </div> </div>  </div> <div id="footer_text"><hr class="nice"> <p>©2025 <a href="https://ivyspring.com" >Ivyspring International Publisher</a>. <a href="/ms/terms">Terms of use</a></p></div> </div> </div> </div> </body></html>