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<!DOCTYPE html> <html lang="en"><head> <meta charset="utf-8"> <title>Volume 21, Issue 4 - ijbs</title> <meta name="viewport" content="width=device-width, initial-scale=1" > <link rel="stylesheet" type="text/css" media="all" href="/ms/css/ivy.css?v=82"> <link rel="stylesheet" type="text/css" media="all and (min-width: 801px)" href="/ms/site/mainnew.css?v=15"> <link rel="stylesheet" type="text/css" media="all and (min-width: 801px)" href="/style.css?v=38"> <link rel="stylesheet" type="text/css" media="all and (max-width: 800px)" href="/ms/css/ivymobile.css?v=34" > <link rel="stylesheet" type="text/css" media="all and (max-width: 800px)" href="/ms/site/sitemobile.css?v=2" > <script src="/ms/java/function.js?v=43"></script> </head> <body id="main_body"> <div id="page_all"> <div id="container"> <div id="header"> <div id="logo" > <div > International Journal of Biological Sciences  </div> </div> <div id="key_visual"> Impact factor 8.2 ISSN: 1449-2288</div> </div> <div id="main_nav_container"> <ul id=main_nav_list><li><a href="/" >Home </a></li><li><a href="/ms/author" >For Authors </a></li><li><a href="/ms/submit" >Submit Manuscript </a></li><li><a href="/ms/status" >Login </a></li><li><a href="/ms/feedback" >Contact </a></li></ul> <div class='topnav-right'> <a href='/ms/userlogin' title='My account'><img src='/ms/images/account.svg' alt='Account' height='24' width='24'> </a> </div> </div> <div id="main_container"> <div id="sub_container1"> <div id="sub_nav_container"> <ul class='sub_nav_list'><li><a href="/currentissue" >Current Issue </a></li><li><a href="/ms/archive/21" >Volume 21; 2025 </a></li><li><a href="/ms/archive/20" >Volume 20; 2024 </a></li><li><a href="/ms/archive/19" >Volume 19; 2023 </a></li><li><a href="/ms/archive/18" >Volume 18; 2022 </a></li><li><a href="/ms/archive/17" >Volume 17; 2021 </a></li><li><a href="/ms/archive" >Archive </a></li><li><a href="/ms/acceptms" >Advance Articles </a></li><li><a href="/editorial" >Editorial Board </a></li><li><a href="/ms/coverimage" >Cover Images </a></li><li><a href="/coverage" >Index & Coverage </a></li><li><a href="/ms/coversuggest" >Cover Suggestion </a></li><li><a href="/specialissue" >Special Issues </a></li></ul> <form method="post" action="/ms/mysearch" class="searchblock" > <input type="text" name="query" size="9" maxlength="255" value="" id="sbi" class="formfield" placeholder="Article title/doi"> <button type="submit" name="search" value="Search" id="sbb" title="Search article by title or doi"><img src='/ms/images/search.svg' alt='Search' height='24' width='24' style='vertical-align: middle;'></button> <input type="hidden" name="content" value="IJBS1449-2288"> </form> <div class='sub_nav_space display_pc'></div> <div class="imagecenter"> <a href="https://www.thno.org" class="textlink">Theranostics</a> <a href="https://www.medsci.org" class="textlink">International Journal of Medical Sciences</a> <a href="https://www.ntno.org" class="textlink">Nanotheranostics</a> <a href="https://www.jcancer.org" class="textlink">Journal of Cancer</a> <a href="https://www.jgenomics.com" class="textlink">Journal of Genomics</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/journals/294/" ><img src="/ms/images/pmclogo.gif" alt="PubMed Central" width="145" height="75" class="imagecenter" ></a> <img src="/ms/images/openaccess.jpg" width="145" height="54" alt="open access"> Global reach, higher impact </div> </div> </div> <div id="sub_container2">  <div class='coverfig imageright' ><img src='cover/thumb/v21i4.jpg' alt='Front cover' onclick="openPopupFig('cover/v21i4.jpg');"> </div> <a class="boxnice" href="v21i3">◂ Last issue</a> <a class="boxnice" href="v21i5">Next issue ▸</a> <a class="boxnice" href="/ms/archive">Archive</a> <a class="boxnice" href="cover/v21i4.pdf">Cover PDF</a>   Volume 21 (4); 2025Research Papers<img width='350' height='291' class='clickfig' src='/v21/p1378/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1378/toc.jpg');"> <a class='linkSameColor' href='/v21p1378.htm'>Ugonin P facilitates chondrogenic properties in chondrocytes by inhibiting miR-3074-5p production: implications for the treatment of arthritic disorders</a> Ting-Kuo Chang, Trung-Loc Ho, Yen-You Lin, Le Huynh Hoai Thuong, Kuan-Ying Lai, Chun-Hao Tsai, Chih-Chuang Liaw, Chih-Hsin Tang Int. J. Biol. Sci. 2025; 21(4): 1378-1390. doi:10.7150/ijbs.108789 <a class='boxtext' href='/v21p1378.htm'>Full text</a> <a class='boxtext' href='/v21p1378.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990652'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844289/'>PMC</a> <hr class='clear'><img width='350' height='168' class='clickfig' src='/v21/p1391/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1391/toc.jpg');"> <a class='linkSameColor' href='/v21p1391.htm'>N6-methyladenosine Reader IGF2BP2-modified HMMR Promotes Non-small Cell Lung Cancer Metastasis via Interaction with MAP4K4</a> Jiansheng Zhang, Mengzhu Zhang, Aimin Qiu, Chang Li, Qiongju Chen, Jianjun Li, Yuanyuan Zeng, Jianjie Zhu, Jian-an Huang, Xiuqin Zhang, Zeyi Liu Int. J. Biol. Sci. 2025; 21(4): 1391-1409. doi:10.7150/ijbs.104097 <a class='boxtext' href='/v21p1391.htm'>Full text</a> <a class='boxtext' href='/v21p1391.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990663'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844294/'>PMC</a> <hr class='clear'><img width='350' height='274' class='clickfig' src='/v21/p1436/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1436/toc.jpg');"> <a class='linkSameColor' href='/v21p1436.htm'>SEC61G Facilitates Brain Metastases via Antagonizing PGAM1 Ubiquitination and Immune Microenvironment Remodeling in Non-Small Cell Lung Cancer</a> Changshuai Zhou, Yuechao Yang, Huanhuan Cui, Sen Li, Zhisu Wang, Lei Chen, Mingtao Feng, Deheng Li, Xin Chen, Bin Hao, Xiaojun Wu, Yang Gao, Liangdong Li, Jiayan Chen, Yiqun Cao Int. J. Biol. Sci. 2025; 21(4): 1436-1458. doi:10.7150/ijbs.109187 <a class='boxtext' href='/v21p1436.htm'>Full text</a> <a class='boxtext' href='/v21p1436.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990664'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844280/'>PMC</a> <hr class='clear'><img width='350' height='224' class='clickfig' src='/v21/p1459/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1459/toc.jpg');"> <a class='linkSameColor' href='/v21p1459.htm'>Hexokinase 2 Suppression Alleviates the Catabolic Properties in Osteoarthritis via HMGA2 and Contributes to Pulsed Electromagnetic Field-mediated Cartilage Protection</a> Chuncha Bao, Siyi Zhu, Dejiang Pang, Ming Yang, Jiapeng Huang, Fengsheng Wang, Yue Hou, Xiangxiu Wang, Yuan Feng, Haolun Yang, Junliang Jiang, Jing He, Chengqi He Int. J. Biol. Sci. 2025; 21(4): 1459-1477. doi:10.7150/ijbs.101597 <a class='boxtext' href='/v21p1459.htm'>Full text</a> <a class='boxtext' href='/v21p1459.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990654'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844298/'>PMC</a> <hr class='clear'><img width='350' height='236' class='clickfig' src='/v21/p1478/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1478/toc.jpg');"> <a class='linkSameColor' href='/v21p1478.htm'>FTO-induced APOE promotes the malignant progression of pancreatic neuroendocrine neoplasms through FASN-mediated lipid metabolism</a> Jinhao Chen, Mujie Ye, Danyang Gu, Ping Yu, Lin Xu, Bingyang Xue, Lijun Yan, Feiyu Lu, Chunhua Hu, Yanling Xu, Xiaoting Shi, Lingyi Chen, Yan Wang, Jianan Bai, Ye Tian, Qiyun Tang Int. J. Biol. Sci. 2025; 21(4): 1478-1496. doi:10.7150/ijbs.103428 <a class='boxtext' href='/v21p1478.htm'>Full text</a> <a class='boxtext' href='/v21p1478.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990672'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844274/'>PMC</a> <hr class='clear'><img width='350' height='205' class='clickfig' src='/v21/p1497/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1497/toc.jpg');"> <a class='linkSameColor' href='/v21p1497.htm'>Solobacterium moorei promotes tumor progression via the Integrin α2/β1-PI3K-AKT-mTOR-C-myc signaling pathway in colorectal cancer</a> Yan Chen, Ying Qin, Tingting Fan, Cheng Qiu, Yijie Zhang, Mengmeng Dai, Yaoyao Zhou, Qinsheng Sun, Yuan Guo, Yue Hao, Yuyang Jiang Int. J. Biol. Sci. 2025; 21(4): 1497-1512. doi:10.7150/ijbs.102742 <a class='boxtext' href='/v21p1497.htm'>Full text</a> <a class='boxtext' href='/v21p1497.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990665'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844286/'>PMC</a> <hr class='clear'><img width='350' height='181' class='clickfig' src='/v21/p1513/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1513/toc.jpg');"> <a class='linkSameColor' href='/v21p1513.htm'>Inhibition of GRK2-PDE4D Axis Suppresses Fibroblast-Like Synoviocytes Hyperplasia and Alleviates Experimental Arthritis</a> Dafei Han, Hanfei Sun, Renhao Zhang, Hui Ge, Paipai Guo, Rui Chu, Ruhong Fang, Yongsheng Han, Shufang He, Rui Li, Jiajie Tu, Wei Wei, Yang Ma, Qingtong Wang Int. J. Biol. Sci. 2025; 21(4): 1513-1529. doi:10.7150/ijbs.100176 <a class='boxtext' href='/v21p1513.htm'>Full text</a> <a class='boxtext' href='/v21p1513.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990667'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844291/'>PMC</a> <hr class='clear'><img width='350' height='223' class='clickfig' src='/v21/p1530/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1530/toc.jpg');"> <a class='linkSameColor' href='/v21p1530.htm'>DARS2 Promotes Bladder Cancer Progression by Enhancing PINK1-Mediated Mitophagy</a> Dongqing Li, Hang Su, Xiaolin Deng, Yuan Huang, Zihuan Wang, Jinge Zhang, Chen Chen, Zaosong Zheng, Qiong Wang, Shanchao Zhao, Zhe-Sheng Chen, Haiyong Chen, Lina Hou, Wanlong Tan, Fei Li Int. J. Biol. Sci. 2025; 21(4): 1530-1544. doi:10.7150/ijbs.107632 <a class='boxtext' href='/v21p1530.htm'>Full text</a> <a class='boxtext' href='/v21p1530.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990673'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844284/'>PMC</a> <hr class='clear'><img width='350' height='229' class='clickfig' src='/v21/p1545/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1545/toc.jpg');"> <a class='linkSameColor' href='/v21p1545.htm'>High-dose Ascorbate Exhibits Anti-proliferative and Anti-invasive Effects Dependent on PTEN/AKT/mTOR Pathway in Endometrial Cancer in vitro and in vivo</a> Xiaochang Shen, Jiandong Wang, Weimin Kong, Catherine John, Boer Deng, Shuning Chen, Haomeng Zhang, Jennifer Haag, Nikita Sinha, Wenchuan Sun, Angeles Alvarez Secord, Chunxiao Zhou, Victoria L Bae-Jump Int. J. Biol. Sci. 2025; 21(4): 1545-1565. doi:10.7150/ijbs.102079 <a class='boxtext' href='/v21p1545.htm'>Full text</a> <a class='boxtext' href='/v21p1545.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990670'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844297/'>PMC</a> <hr class='clear'><img width='350' height='166' class='clickfig' src='/v21/p1566/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1566/toc.jpg');"> <a class='linkSameColor' href='/v21p1566.htm'>Mannose Inhibits NSCLC Growth and Inflammatory Microenvironment by Regulating Gut Microbiota and Targeting OGT/hnRNP R/JUN/IL-8 Axis</a> Haoyi Jin, Huanghe He, Jijia Li, Xi Liu, Qi Cai, Jiang Shi, Zhexue Hao, Jianxing He Int. J. Biol. Sci. 2025; 21(4): 1566-1584. doi:10.7150/ijbs.107256 <a class='boxtext' href='/v21p1566.htm'>Full text</a> <a class='boxtext' href='/v21p1566.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990658'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844275/'>PMC</a> <hr class='clear'><img width='350' height='157' class='clickfig' src='/v21/p1585/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1585/toc.jpg');"> <a class='linkSameColor' href='/v21p1585.htm'>DNMT3a promotes LUAD cell proliferation and metastasis by activating the HDAC7 signalling pathway</a> Menglong Jiang, Xin Zhou, Yingtong Feng, Peng Ding, Jinfeng Li, Di Lu, Jiapei Qin, Yibing Bai, An Wang, Chunfang Xia, Jinliang Wang, Xiaolong Yan, Zhiqiang Ma, Renquan Zhang Int. J. Biol. Sci. 2025; 21(4): 1585-1602. doi:10.7150/ijbs.96509 <a class='boxtext' href='/v21p1585.htm'>Full text</a> <a class='boxtext' href='/v21p1585.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990668'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844290/'>PMC</a> <hr class='clear'><img width='350' height='244' class='clickfig' src='/v21/p1603/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1603/toc.jpg');"> <a class='linkSameColor' href='/v21p1603.htm'>Prp19/CDC5L promotes gastric cancer via activation of the MAPK pathway-mediated homologous recombination</a> Shengkui Qiu, Feiran Wang, Xuesong Gao, Weiyu Guan, Ting Dai, Lei Yin, Fei Wang, Jinjie Sun, Peng Guo, Hao Wu, Shichun Feng, Chong Tang Int. J. Biol. Sci. 2025; 21(4): 1603-1618. doi:10.7150/ijbs.101962 <a class='boxtext' href='/v21p1603.htm'>Full text</a> <a class='boxtext' href='/v21p1603.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990666'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844288/'>PMC</a> <hr class='clear'><img width='350' height='228' class='clickfig' src='/v21/p1619/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1619/toc.jpg');"> <a class='linkSameColor' href='/v21p1619.htm'>Chloroquine Suppresses Colorectal Cancer Progression via Targeting CHKA and PFKM to inhibit the PI3K/AKT Pathway and the Warburg Effect</a> Yanqing Liu, Yongping Zhu, Liwei Gu, Kexin Li, Ang Ma, Li Liu, Yuqing Meng, Junzhe Zhang, Shengnan Shen, Qiaoli Shi, Dandan Liu, Xinwei Zhang, Shujie Zhang, Xin Chai, Peng Gao, Jiale Xing, Yaxu Wang, Honglin Chen, Rui Liu, Qingfeng Du, Haitao Liu, Lingyun Dai, Jigang Wang Int. J. Biol. Sci. 2025; 21(4): 1619-1631. doi:10.7150/ijbs.101921 <a class='boxtext' href='/v21p1619.htm'>Full text</a> <a class='boxtext' href='/v21p1619.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990656'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844273/'>PMC</a> <hr class='clear'><img width='350' height='249' class='clickfig' src='/v21/p1632/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1632/toc.jpg');"> <a class='linkSameColor' href='/v21p1632.htm'>BAP31-ELAVL1-SPINK6 axis induces loss of cell polarity and promotes metastasis in hepatocellular carcinoma</a> Xiyang Zhang, Jing Wang, Xiaohua Liang, Dongbo Jiang, Yuanjie Sun, Chenchen Hu, Feiming Hu, Yuanli He, Yubo Sun, Junqi Zhang, Jiaqi Ding, Sirui Cai, Yueyue Wang, Shuya Yang, Kun Yang Int. J. Biol. Sci. 2025; 21(4): 1632-1648. doi:10.7150/ijbs.102566 <a class='boxtext' href='/v21p1632.htm'>Full text</a> <a class='boxtext' href='/v21p1632.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990675'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844287/'>PMC</a> <hr class='clear'><img width='350' height='166' class='clickfig' src='/v21/p1666/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1666/toc.jpg');"> <a class='linkSameColor' href='/v21p1666.htm'>BCLAF1 Regulates Osteoarthritic Cartilage Degradation Through Interaction with LAMTOR2</a> Song Li, Danni Luo, Yulin Liang, Yi Zou, Hongxu Pu, Meng Zheng, Yuting Wang, Xuying Sun, Hao Zhu, Yuanli Zhu, Liming Zhao, Jun Xiao Int. J. Biol. Sci. 2025; 21(4): 1666-1685. doi:10.7150/ijbs.100396 <a class='boxtext' href='/v21p1666.htm'>Full text</a> <a class='boxtext' href='/v21p1666.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990659'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844276/'>PMC</a> <hr class='clear'><img width='350' height='178' class='clickfig' src='/v21/p1705/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1705/toc.jpg');"> <a class='linkSameColor' href='/v21p1705.htm'>Prolonged DEHP exposure enhances the stemness and metastatic potential of TNBC cells in an MSI2-dependent manner</a> Mahendra Jadhao, Sheng-Kai Hsu, Dhanashri Deshmukh, Pei-Feng Liu, Shih-Feng Weng, Yih-Fung Chen, Chia-Yang Li, Chia-Yih Wang, Eing-Mei Tsai, Li-Fang Wang, Chien-Chih Chiu Int. J. Biol. Sci. 2025; 21(4): 1705-1729. doi:10.7150/ijbs.101598 <a class='boxtext' href='/v21p1705.htm'>Full text</a> <a class='boxtext' href='/v21p1705.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990676'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844279/'>PMC</a> <hr class='clear'><img width='350' height='178' class='clickfig' src='/v21/p1730/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1730/toc.jpg');"> <a class='linkSameColor' href='/v21p1730.htm'>Disulfiram/copper triggers cGAS-STING innate immunity pathway via ROS-induced DNA damage that potentiates antitumor response to PD-1 checkpoint blockade</a> Mengmeng Yuan, Liang Shi, Yan Liu, Ke Xiang, Yan Zhang, Ye Zhou, Jianling Wang, Meiju Ji, Peng Hou Int. J. Biol. Sci. 2025; 21(4): 1730-1748. doi:10.7150/ijbs.105575 <a class='boxtext' href='/v21p1730.htm'>Full text</a> <a class='boxtext' href='/v21p1730.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990655'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844283/'>PMC</a> <hr class='clear'><img width='350' height='243' class='clickfig' src='/v21/p1749/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1749/toc.jpg');"> <a class='linkSameColor' href='/v21p1749.htm'>Febuxostat therapy improved the outcomes of cardiorenal syndrome rodent through alleviating xanthine oxidase-induced oxidative stress and mitochondrial dysfunction</a> Chih-Chao Yang, Ya Yue, Yi-Ling Chen, John Y. Chiang, Yi-Ting Wang, Chi-Ruei Huang, Ben-Chung Cheng, Tsuen-Wei Hsu, Hon-Kan Yip Int. J. Biol. Sci. 2025; 21(4): 1749-1766. doi:10.7150/ijbs.99194 <a class='boxtext' href='/v21p1749.htm'>Full text</a> <a class='boxtext' href='/v21p1749.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990671'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844282/'>PMC</a> <hr class='clear'><img width='350' height='222' class='clickfig' src='/v21/p1784/toc.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1784/toc.jpg');"> <a class='linkSameColor' href='/v21p1784.htm'>The E3 ubiquitin ligase MAEA promotes macrophage phagocytosis and inhibits gastrointestinal cancer progression by mediating PARP1 ubiquitination and degradation</a> Yanchun Feng, Xiangcai Zou, Jintuan Huang, Zhenze Huang, Guanghao Kuang, Yingming Jiang Int. J. Biol. Sci. 2025; 21(4): 1784-1800. doi:10.7150/ijbs.102796 <a class='boxtext' href='/v21p1784.htm'>Full text</a> <a class='boxtext' href='/v21p1784.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990651'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844278/'>PMC</a> <hr class='clear'><img width='350' height='285' class='clickfig' src='/v21/p1801/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1801/toc.jpg');"> <a class='linkSameColor' href='/v21p1801.htm'>FBXW7 Directly Ubiquitinates and Degrades CTNNB1 Mediating the Suppression of ENKUR in Endometrial Cancer</a> YaHui Liu, Qian Wang, QiRun Guo, Ying Zhu, Li Lin, ChunYan Yang, Bin Gong, Weiwei Yan, RenTao Hou, Yao Tang, XiuQiong Wu, Xinhui Liu, BeiXian Zhou, WeiYi Fang, LuYun Shu, SuiQun Guo Int. J. Biol. Sci. 2025; 21(4): 1801-1817. doi:10.7150/ijbs.104067 <a class='boxtext' href='/v21p1801.htm'>Full text</a> <a class='boxtext' href='/v21p1801.pdf'>PDF</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pubmed/39990660'>PubMed</a> <a class='boxtext' href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844281/'>PMC</a> <hr class='clear'><img width='350' height='250' class='clickfig' src='/v21/p1837/tocs.jpg' alt='Graphic abstract' onclick="openPopupFig('/v21/p1837/toc.jpg');"> <a class='linkSameColor' href='/v21p1837.htm'>METTL3-mediated m6A modification of SLC7A11 enhances nasopharyngeal carcinoma radioresistance by inhibiting ferroptosis</a> Zili Dai, Baisheng Lin, Maohua Qin, Yunen Lin, Li Wang, Kai Liao, Guofeng Xie, Feixiang Wang, Jian Zhang Int. J. Biol. 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