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Positive blood cultures may help provide clinical diagnosis, as well as a specific etiological diagnosis. Neonatal septicemia constitutes an important cause of morbidity and mortality amongst neonates in India. However, with presently available antimicrobial agents, neonatal septicemia may be treated successfully. Early diagnosis and proper management of neonatal septicemia can bring down the morbidity and mortality substantially. Hence, the present study was undertaken to study the bacteriological profile of neonatal septicemia cases and their antimicrobial sensitivity pattern for planning strategy in the management of these cases. Materials and Methods: This retrospective study was carried out in the CNBC and MYH, department of microbiology and paediatrics, M.G.M. medical college and M.Y. hospital, Indore, from January to December in 1000 blood cultures. Identification of organism was done as per standard methods like gram’s staining, cultural characteristics, motility and biochemical reactions. Results: In our study done on 1000 neonatal blood cultures, we found 42.2 % cultures were positive, in which 51.3 % were males and 48.7 % were female neonates. We found 52.8 % were Early onset septicaemia (EOS) (\u0026amp;lt;2 days) and 47.2 % were late onset septicemia (LOS) (\u0026amp;gt;2 days). Among 1000 neonates 543 were institutional delivered (inborn) and 457 were out born referred from other hospitals; 64.7 % were term, 35.3 % were preterm, 80.1 % were normal deliveries and 19.9 % were LSCS. Key words: Septicaemia, Blood culture, CoNS, MRSA, EOS, LOS","author":[{"@context":"https://schema.org","@type":"Person","name":"Sadhana Sodani"},{"@context":"https://schema.org","@type":"Person","name":"IP Innovative Publication Pvt. Ltd."}],"contributor":[{"@context":"https://schema.org","@type":"Person","name":"Sadhana Sodani"}],"dateCreated":"2015-10-15","dateModified":"2015-10-24","datePublished":null,"headline":"Study of the Prevalence of Neonatal Septicaemia with Antibiotic Susceptibility in a Large Tertiary Care Hospital","inLanguage":"en","keywords":["Indian Journal of Microbiology Research"],"locationCreated":null,"publication":null,"publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/16826206/Study_of_the_Prevalence_of_Neonatal_Septicaemia_with_Antibiotic_Susceptibility_in_a_Large_Tertiary_Care_Hospital","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"dauniv"},{"@context":"https://schema.org","@type":"EducationalOrganization","name":"innovativepublication"}]}</script><link rel="stylesheet" media="all" 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F16826206%2FStudy_of_the_Prevalence_of_Neonatal_Septicaemia_with_Antibiotic_Susceptibility_in_a_Large_Tertiary_Care_Hospital%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F16826206%2FStudy_of_the_Prevalence_of_Neonatal_Septicaemia_with_Antibiotic_Susceptibility_in_a_Large_Tertiary_Care_Hospital%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":39203290,"identifier":"Attachment_39203290","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":16826206,"created_at":"2015-10-15T04:20:40.525-07:00","from_world_paper_id":null,"updated_at":"2021-01-17T16:54:13.697-08:00","_data":{"abstract":"Introduction: Invasion of the blood stream by microorganisms constitutes one of the most serious situations in infectious disease and as a result, timely detection and identification of blood borne pathogens is one of the most important functions of the microbiology laboratory. Positive blood cultures may help provide clinical diagnosis, as well as a specific etiological diagnosis.\nNeonatal septicemia constitutes an important cause of morbidity and mortality amongst neonates in India. However, with presently available antimicrobial agents, neonatal septicemia may be treated successfully. Early diagnosis and proper management of neonatal septicemia can bring down the morbidity and mortality substantially. Hence, the present study was undertaken to study the bacteriological profile of neonatal septicemia cases and their antimicrobial sensitivity pattern for planning strategy in the management of these cases.\nMaterials and Methods: This retrospective study was carried out in the CNBC and MYH, department of microbiology and paediatrics, M.G.M. medical college and M.Y. hospital, Indore, from January to December in 1000 blood cultures. Identification of organism was done as per standard methods like gram’s staining, cultural characteristics, motility and biochemical reactions.\nResults: In our study done on 1000 neonatal blood cultures, we found 42.2 % cultures were positive, in which 51.3 % were males and 48.7 % were female neonates. We found 52.8 % were Early onset septicaemia (EOS) (\u003c2 days) and 47.2 % were late onset septicemia (LOS) (\u003e2 days). Among 1000 neonates 543 were institutional delivered (inborn) and 457 were out born referred from other hospitals; 64.7 % were term, 35.3 % were preterm, 80.1 % were normal deliveries and 19.9 % were LSCS.\nKey words: Septicaemia, Blood culture, CoNS, MRSA, EOS, LOS"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Study of the Prevalence of Neonatal Septicaemia with Antibiotic Susceptibility in a Large Tertiary Care Hospital","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [36854590,27377481]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":39203290,"attachmentType":"pdf"}"><img alt="First page of “Study of the Prevalence of Neonatal Septicaemia with Antibiotic Susceptibility in a Large Tertiary Care Hospital”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/39203290/mini_magick20190223-30840-1ddrmil.png?1550931277" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Study of the Prevalence of Neonatal Septicaemia with Antibiotic Susceptibility in a Large Tertiary Care Hospital</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="36854590" href="https://dauniv.academia.edu/SadhanaSodani"><img alt="Profile image of Sadhana Sodani" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/36854590/10522652/11742407/s65_sadhana.sodani.jpg" />Sadhana Sodani</a><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="27377481" href="https://innovativepublication.academia.edu/IP"><img alt="Profile image of IP Innovative Publication Pvt. Ltd." class="ds-work-card--author-avatar" src="https://0.academia-photos.com/27377481/8351640/25499110/s65_ip_innovative.publication_pvt._ltd..png" />IP Innovative Publication Pvt. Ltd.</a></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Introduction: Invasion of the blood stream by microorganisms constitutes one of the most serious situations in infectious disease and as a result, timely detection and identification of blood borne pathogens is one of the most important functions of the microbiology laboratory. Positive blood cultures may help provide clinical diagnosis, as well as a specific etiological diagnosis. Neonatal septicemia constitutes an important cause of morbidity and mortality amongst neonates in India. However, with presently available antimicrobial agents, neonatal septicemia may be treated successfully. Early diagnosis and proper management of neonatal septicemia can bring down the morbidity and mortality substantially. Hence, the present study was undertaken to study the bacteriological profile of neonatal septicemia cases and their antimicrobial sensitivity pattern for planning strategy in the management of these cases. Materials and Methods: This retrospective study was carried out in the CNBC and MYH, department of microbiology and paediatrics, M.G.M. medical college and M.Y. hospital, Indore, from January to December in 1000 blood cultures. Identification of organism was done as per standard methods like gram’s staining, cultural characteristics, motility and biochemical reactions. Results: In our study done on 1000 neonatal blood cultures, we found 42.2 % cultures were positive, in which 51.3 % were males and 48.7 % were female neonates. We found 52.8 % were Early onset septicaemia (EOS) (<2 days) and 47.2 % were late onset septicemia (LOS) (>2 days). Among 1000 neonates 543 were institutional delivered (inborn) and 457 were out born referred from other hospitals; 64.7 % were term, 35.3 % were preterm, 80.1 % were normal deliveries and 19.9 % were LSCS. Key words: Septicaemia, Blood culture, CoNS, MRSA, EOS, LOS</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":39203290,"attachmentType":"pdf","workUrl":"https://www.academia.edu/16826206/Study_of_the_Prevalence_of_Neonatal_Septicaemia_with_Antibiotic_Susceptibility_in_a_Large_Tertiary_Care_Hospital"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":39203290,"attachmentType":"pdf","workUrl":"https://www.academia.edu/16826206/Study_of_the_Prevalence_of_Neonatal_Septicaemia_with_Antibiotic_Susceptibility_in_a_Large_Tertiary_Care_Hospital"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="39203290" data-landing_url="https://www.academia.edu/16826206/Study_of_the_Prevalence_of_Neonatal_Septicaemia_with_Antibiotic_Susceptibility_in_a_Large_Tertiary_Care_Hospital" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="107282035" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/107282035/Bacteriological_profile_and_antibiogram_of_Neonatal_septicaemia_in_a_tertiary_care_hospital">Bacteriological profile & antibiogram of Neonatal septicaemia in a tertiary care hospital</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="278023368" href="https://independent.academia.edu/MunmunDasSarkar">Munmun Das Sarkar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International journal of scientific research, 2021</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Bacteriological profile \u0026 antibiogram of Neonatal septicaemia in a tertiary care hospital","attachmentId":105993480,"attachmentType":"pdf","work_url":"https://www.academia.edu/107282035/Bacteriological_profile_and_antibiogram_of_Neonatal_septicaemia_in_a_tertiary_care_hospital","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/107282035/Bacteriological_profile_and_antibiogram_of_Neonatal_septicaemia_in_a_tertiary_care_hospital"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="68536674" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/68536674/Neonatal_septicemia_and_current_scenario_of_antibiotic_sensitivity_pattern_A_study_of_blood_culture_isolates_in_a_tertiary_care_hospital_Rajkot">Neonatal septicemia and current scenario of antibiotic sensitivity pattern – A study of blood culture isolates in a tertiary care hospital, Rajkot</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="252465053" href="https://independent.academia.edu/ArpitaBhattacharya26">Arpita Bhattacharya</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="57406344" href="https://aiims1.academia.edu/TWINKLEKUMARPARMAR">TWINKLEKUMAR K PARMAR</a></div><p class="ds-related-work--metadata ds2-5-body-xs">IP International Journal of Medical Microbiology and Tropical Diseases, 2021</p><p class="ds-related-work--abstract ds2-5-body-sm">Neonatal sepsis is one of the leading causes of neonatal mortality in developing countries. Neonatal sepsis can be classified into two subtypes depending upon onset of symptoms- before 72 hours of life (early-onset neonatal sepsis—EONS) or later (late-onset neonatal sepsis—LONS). Bacteriological profile and antibiotic susceptibility pattern in neonatal septicemia are changing time-to-time and place-to-place. This study is aimed to know the current scenario of neonatal septicemia and antibiotic susceptibility pattern for determining effective treatment, hence reducing burden of antibiotic resistance.This is a Retrospective study. Data was collected from Bacteriology lab, PDUMC Rajkot (May 2020 – May 2021). Blood cultures were performed on suspected neonates. Both BACTEC and conventional methods were used. Organisms were isolated by standard microbiological protocols and antibiotic sensitivity was performed by Kirby-Bauer disc diffusion method as per CLSI- 2020/2021 guidelines. Total ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neonatal septicemia and current scenario of antibiotic sensitivity pattern – A study of blood culture isolates in a tertiary care hospital, Rajkot","attachmentId":78977149,"attachmentType":"pdf","work_url":"https://www.academia.edu/68536674/Neonatal_septicemia_and_current_scenario_of_antibiotic_sensitivity_pattern_A_study_of_blood_culture_isolates_in_a_tertiary_care_hospital_Rajkot","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/68536674/Neonatal_septicemia_and_current_scenario_of_antibiotic_sensitivity_pattern_A_study_of_blood_culture_isolates_in_a_tertiary_care_hospital_Rajkot"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="91832724" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/91832724/Study_of_the_bacteriological_profile_of_neonatal_septicemia_and_associated_risk_factors">Study of the bacteriological profile of neonatal septicemia and associated risk factors</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="129543229" href="https://independent.academia.edu/amruthakumari2">amrutha kumari</a></div><p class="ds-related-work--metadata ds2-5-body-xs">IP International Journal of Medical Microbiology and Tropical Diseases, 2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Study of the bacteriological profile of neonatal septicemia and associated risk factors","attachmentId":95007361,"attachmentType":"pdf","work_url":"https://www.academia.edu/91832724/Study_of_the_bacteriological_profile_of_neonatal_septicemia_and_associated_risk_factors","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/91832724/Study_of_the_bacteriological_profile_of_neonatal_septicemia_and_associated_risk_factors"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="26998950" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26998950/Bacteriological_profile_and_antibiogram_of_neonatal_septicemia_in_a_tertiary_care_hospital">Bacteriological profile and antibiogram of neonatal septicemia in a tertiary care hospital</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27377481" href="https://innovativepublication.academia.edu/IP">IP Innovative Publication Pvt. Ltd.</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Innovative publication, 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Neonatal sepsis is a clinical syndrome which is characterised by signs and symptoms of infection which may or may not be accompanied by bacteraemia within the first month of life. The bacteriological profile of neonatal sepsis is under constant change with the advances in the diagnosis and treatment. Blood culture is still the mainstay of investigation of potential sepsis in spite of the recent advances in molecular diagnosis of fungal and bacterial sepsis. Most common bacterial organisms responsible for neonatal septicaemia in developing countries like Bangladesh, India, Nigeria, Pakistan, are Klebsiella, Escherichia coli, Enterobacter etc. The present study was undertaken to describe the spectrum of the isolates in cases of neonatal septicaemia, and their antimicrobial susceptibility pattern. The study was carried out over a one year period. Method: A total of 357 suspected patients of neonatal septicaemia were included in the study. Blood samples were collected with aseptic precautions preferably prior to the initiation of empiric antibiotic therapy. The bottles were incubated aerobically at 37 0 C for 7 days and subcultured on blood agar and Mac Conkey agar. If growth appeared the isolates were processed as per standard microbiological techniques and the isolates were identified. Antibiotic sensitivity testing was performed on Mueller‑Hinton agar plates by modified Kirby‑Bauer disk diffusion method as per Clinical Laboratory Standard Institute guidelines. Results: Of the 357 samples studied, growth was observed in 154 samples. Gram positive organisms constituted 37.66% and gram negative bacilli constituted 62.34% of the isolates. The predominant pathogens isolated were Klebsiella species, Coagulase Negative Staphylococci, Staphylococcus aureus followed by Non fermenting gram negative bacilli. 71.43% of the Staphylococcus aureus isolates were found to be methicillin resistant.96.05% of the Enterobacteriaceae were found to be Extended Spectrum Beta Lactamase (ESBL) producers. 33.33% of the Pseudomonas isolates were found to be metallo-beta-lactamase (MBL) producers. Conclusion: This study shows that Klebsiella species, Coagulase Negative Staphylococci, Staphylococcus aureus and Non-fermenting gram negative bacilli were the commonest organisms associated with Neonatal sepsis. An alarmingly high rate of MRSA and ESBL producers was observed. This study stresses that antimicrobial resistance is a universal problem and it stresses the need for surveillance.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Bacteriological profile and antibiogram of neonatal septicemia in a tertiary care hospital","attachmentId":47259736,"attachmentType":"pdf","work_url":"https://www.academia.edu/26998950/Bacteriological_profile_and_antibiogram_of_neonatal_septicemia_in_a_tertiary_care_hospital","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26998950/Bacteriological_profile_and_antibiogram_of_neonatal_septicemia_in_a_tertiary_care_hospital"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="43032656" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/43032656/Bacteriology_of_neonatal_septicemias_in_a_tertiary_care_hospital">Bacteriology of neonatal septicemias in a tertiary care hospital</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27377481" href="https://innovativepublication.academia.edu/IP">IP Innovative Publication Pvt. Ltd.</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="158794764" href="https://independent.academia.edu/YRRReddy">Y. R. R. Reddy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">IP innovative publication pvt ltd, 2020</p><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: Neonatal sepsis is the second leading cause of mortality with an annual toll of more than one million deaths of the newborn. The incidence and subsequent risk factors in the clinical management of newborn sepsis is a continuing major global public health concern. Although variety of sepsis screening methods available, blood culture and sensitivity is considered as the most promising test for diagnosis of neonatal septicemia because, the type of microorganisms associated and their antibiotic sensitivity pattern vary significantly. Materials and Methods: A retrospective analysis of blood cultures was carried out in the department of microbiology, SVS medical college, Mahabubnagar, Telangana for the period of June 2017 to October 2019. Blood cultures (in BacT/Alert, biomerieux) were incubated and growth was identified as per the standard protocols. Antibiotic sensitivity testing of the isolates was performed in VITEK 2-compact (biomerieux). Results: From a total of 210 positive samples, the incidence of Gram negative bacilli predominates (65.2%) the Gram positive cocci (34.8%). Klebsiella species (94 out of 137) and coagulase negative Staphylococci (61 out of 73) are the most predominant bacteria isolated from neonatal sepsis. Antibiotic sensitivity pattern of the isolates varies significantly. However, most widely used carbapenems and cephalosporins demonstrated only marginal efficacy towards enteric GNB. Conclusion: Surveillance for emerging MDR pathogens is essential to monitor changing epidemiological trends to guide optimum empirical therapy.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Bacteriology of neonatal septicemias in a tertiary care hospital","attachmentId":63294192,"attachmentType":"pdf","work_url":"https://www.academia.edu/43032656/Bacteriology_of_neonatal_septicemias_in_a_tertiary_care_hospital","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/43032656/Bacteriology_of_neonatal_septicemias_in_a_tertiary_care_hospital"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="74664296" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74664296/Incidence_and_Antimicrobial_Susceptibility_Pattern_of_Neonatal_Septicaemia_from_Tertiary_Care_Hospital_of_India">Incidence and Antimicrobial Susceptibility Pattern of Neonatal Septicaemia from Tertiary Care Hospital of India</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="23904717" href="https://independent.academia.edu/MoumitaSardar">Moumita Sardar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Medical and Clinical Research, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Incidence and Antimicrobial Susceptibility Pattern of Neonatal Septicaemia from Tertiary Care Hospital of India","attachmentId":82735207,"attachmentType":"pdf","work_url":"https://www.academia.edu/74664296/Incidence_and_Antimicrobial_Susceptibility_Pattern_of_Neonatal_Septicaemia_from_Tertiary_Care_Hospital_of_India","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74664296/Incidence_and_Antimicrobial_Susceptibility_Pattern_of_Neonatal_Septicaemia_from_Tertiary_Care_Hospital_of_India"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="103671698" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/103671698/Bacteriological_Profile_of_Suspected_Neonatal_Septicaemia_and_Its_Relationship_with_Selected_Risk_Factors">Bacteriological Profile of Suspected Neonatal Septicaemia and Its Relationship with Selected Risk Factors</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="274505064" href="https://independent.academia.edu/BelalUddin47">Belal Uddin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Medicine Today</p><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: Neonatal septicaemia is one of the major problem in neonatology with a high case fatality rate. Manifestations of neonatal septicaemia are subtle & non-specific. Blood culture is the “gold standard” in the diagnosis of neonatal septicaemia, a high index of suspicion with or without laboratory evidences of infection is the key for early diagnosis. Early diagnosis & introduction of antibiotic may reduce mortality and morbidity. Objective: To explore the bacterial organisms among the suspected neonatal septicaemic cases and its relationship with selected risk factors. Materials and Methods: A Cross sectional descriptive type of study was carried out on all suspected cases of neonatal septicaemia patients admitted in the paediatric wards of Rajshahi Medical College Hospital during the period of july 2008 to june 2010 .Total 60 sixty cases who had non- specific symptoms of septicaemia were enrolled in this study. After a clinical evaluation and management of the patient blo...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Bacteriological Profile of Suspected Neonatal Septicaemia and Its Relationship with Selected Risk Factors","attachmentId":103617306,"attachmentType":"pdf","work_url":"https://www.academia.edu/103671698/Bacteriological_Profile_of_Suspected_Neonatal_Septicaemia_and_Its_Relationship_with_Selected_Risk_Factors","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/103671698/Bacteriological_Profile_of_Suspected_Neonatal_Septicaemia_and_Its_Relationship_with_Selected_Risk_Factors"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="100851501" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/100851501/BIOCHEMICAL_PROFILE_BACTERIAL_PROFILE_AND_ANTIBIOTIC_SUSCEPTIBILITY_PATTERN_OF_THE_ISOLATES_OF_NEONATAL_SEPTICEMIA_IN_TERTIARY_CARE_HOSPITAL_VISAKHAPATNAM">BIOCHEMICAL PROFILE, BACTERIAL PROFILE, AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF THE ISOLATES OF NEONATAL SEPTICEMIA IN TERTIARY CARE HOSPITAL, VISAKHAPATNAM</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="263511221" href="https://independent.academia.edu/AsianJournalofPharmaceuticalandClinicalResearch">Asian Journal of Pharmaceutical and Clinical Research Journal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Asian Journal of Pharmaceutical and Clinical Research Journal, 2022</p><p class="ds-related-work--abstract ds2-5-body-sm">Objectives: The objective of the study was to determine sensitivity, specificity, and predictive values of C-reactive protein (CRP), leukocyte count, platelet count, and blood culture as indicators of neonatal sepsis. Methods: This prospective study was conducted in the Department of Paediatrics, GITAM Institute of Medical sciences and Research, Visakhapatnam during January 2019 to December 2019. The institutional ethics committee had approved the study. Eighty clinically suspected cases of neonatal sepsis constituted material of study. All neonates who were clinically suspected sepsis, categorized into 0-72 h (early onset) or late onset (>3 days) sepsis based on day of presentation. Detailed history and clinical findings were recorded in the pro forma and screened with CRP and various hematological tests with predetermined cutoff values and at the same time blood culture was sent. Concerning a clinical scenario CSF, urine analysis, chest X-ray, and infective focus swabs were all taken. The length of treatment and time spent in the hospital were recorded. The death rate was calculated, and numerous risk variables were evaluated. Results: Intrapartum risk factors such as a prolonged rupture of membrane >24 h, a long labor, several filthy vaginal examinations (>3) before birth, and foul-smelling liquid were all linked to culture-proven newborn sepsis. Any of the two risk factors listed above was a good predictor of sepsis with a positive culture. Neonatal sepsis impacted a higher percentage of low birth weight and preterm babies. The sensitivity and negative predictive value of the I/T ratio and CRP were both high. The most prevalent isolates were Klebsiella species, followed by Staphylococcus aureus and Escherichia coli. While S. aureus was 80% sensitive to Cefotaxime and Amikacin, Klebsiella species and E. coli were only 20% sensitive. All were sensitive to Ofloxacin in range of 75-100%. Septicemia with multiorgan dysfunction was the most common mode of death with 100% risk of mortality. Conclusion: Intraparum risk factors are significantly with culture proven sepsis. All sepsis screening parameters used were statistically significantly associated with culture proven sepsis. I/T ratio and CRP were more sensitivity and had high negative predictive value. CRP can be used as an early and predictable screening test for diagnosing neonatal sepsis.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"BIOCHEMICAL PROFILE, BACTERIAL PROFILE, AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF THE ISOLATES OF NEONATAL SEPTICEMIA IN TERTIARY CARE HOSPITAL, VISAKHAPATNAM","attachmentId":101555595,"attachmentType":"pdf","work_url":"https://www.academia.edu/100851501/BIOCHEMICAL_PROFILE_BACTERIAL_PROFILE_AND_ANTIBIOTIC_SUSCEPTIBILITY_PATTERN_OF_THE_ISOLATES_OF_NEONATAL_SEPTICEMIA_IN_TERTIARY_CARE_HOSPITAL_VISAKHAPATNAM","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/100851501/BIOCHEMICAL_PROFILE_BACTERIAL_PROFILE_AND_ANTIBIOTIC_SUSCEPTIBILITY_PATTERN_OF_THE_ISOLATES_OF_NEONATAL_SEPTICEMIA_IN_TERTIARY_CARE_HOSPITAL_VISAKHAPATNAM"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="54963671" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/54963671/A_hospital_based_study_on_clinico_microbiological_profile_of_neonatal_septicemia">A hospital based study on clinico microbiological profile of neonatal septicemia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="29935138" href="https://independent.academia.edu/GandhariBasu">Gandhari Basu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Asian Journal of Medical Sciences</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Globally, neonatal septicaemia is one of the common causes of neonatal death making it a grave problem. Timely diagnosis and adequate treatment is crucial for managing this burning issue.Aims and Objectives: Early detection of neonatal septicaemia along with its infective etiological agent(s) and assessment of antimicrobial sensitivity pattern.Materials and Methods: After getting approval from institutional ethics committee, an institution based observational, epidemiological study was conducted in ninety two neonates, clinically suspected for sepsis, admitted in neonatal intensive care unit (NICU) were included in the study. Written consent was obtained from their guardian. Blood was drawn from the neonates for estimating routine parameters and cultured for isolation of causative agents using standard protocol. Isolates were identified by staining and biochemical parameters.Results: The present study had 92 neonates, out of which 53 were male and 39 were female. Bad obs...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A hospital based study on clinico microbiological profile of neonatal septicemia","attachmentId":71068014,"attachmentType":"pdf","work_url":"https://www.academia.edu/54963671/A_hospital_based_study_on_clinico_microbiological_profile_of_neonatal_septicemia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/54963671/A_hospital_based_study_on_clinico_microbiological_profile_of_neonatal_septicemia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="50377164" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/50377164/The_bacterial_profile_of_neonatal_septicaemia_in_a_rural_hospital_in_south_India">The bacterial profile of neonatal septicaemia in a rural hospital in south India</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="60664201" href="https://independent.academia.edu/HermanEdwin">Edwin Dias</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The bacterial profile of neonatal septicaemia in a rural hospital in south India","attachmentId":68390370,"attachmentType":"pdf","work_url":"https://www.academia.edu/50377164/The_bacterial_profile_of_neonatal_septicaemia_in_a_rural_hospital_in_south_India","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/50377164/The_bacterial_profile_of_neonatal_septicaemia_in_a_rural_hospital_in_south_India"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":39203290,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":39203290,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_39203290" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="92148447" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92148447/Clinical_and_Bacteriological_Profile_of_Neonatal_Septicaemia_at_A_Community_Level_Medical_College_Hospital">Clinical and Bacteriological Profile of Neonatal Septicaemia at A Community Level Medical College Hospital</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="227760845" href="https://independent.academia.edu/DrKajlaBasu">Dr.Kajla Basu</a></div><p class="ds-related-work--metadata 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Farouk</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Sierra Leone Journal of Biomedical Research, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Risk Factors and Bacterial Profile of Suspected Neonatal Septicaemia at a Teaching Hospital in Kano, Northwestern, Nigeria","attachmentId":99943872,"attachmentType":"pdf","work_url":"https://www.academia.edu/98651694/Risk_Factors_and_Bacterial_Profile_of_Suspected_Neonatal_Septicaemia_at_a_Teaching_Hospital_in_Kano_Northwestern_Nigeria","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/98651694/Risk_Factors_and_Bacterial_Profile_of_Suspected_Neonatal_Septicaemia_at_a_Teaching_Hospital_in_Kano_Northwestern_Nigeria"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related topics</h2><div class="ds-research-interests--pills-container"><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="2180876" href="https://www.academia.edu/Documents/in/Indian_Journal_of_Microbiology_Research">Indian Journal of Microbiology R...</a></div></div></div></div></div><div class="footer--content"><ul class="footer--main-links hide-on-mobile"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a href="https://support.academia.edu/"><svg style="width: 12px; height: 12px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer--research-interests"><li>Find new research papers in:</li><li><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul><ul class="footer--legal-links hide-on-mobile"><li><a href="https://www.academia.edu/terms">Terms</a></li><li><a href="https://www.academia.edu/privacy">Privacy</a></li><li><a href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div> </body> </html>