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NICU. Newborn blood culture and sensitivity testing are important tools in the diagnosis of neonatal sepsis and in the institution of early antibiotic treatment. Material and Methods: This study was conducted by analyzing the blood cultures and the sensitivity reports of 100 newborns who were admitted to the NICU over a period preceding one year. Results: Of the 100 newborns, 32 (32%) showed positive blood culture reports. Out of the 32 positive blood cultures, 19 (59.4%) showed positivity for Coagulase negative Staphylococcus, 7 (21.9%) showed positivity for Staphylococcus aureus, 3 (9.4%) showed positivity for Pseudomonas aeruginosa, 1 (3.1%) showed positivity for Enterococci, 1 (3.1%) showed positivity for Micrococci and 1 (3.1%) showed positivity for Flavobacteria. Overall, most of the neonatal sepsis was caused by Coagulase negative staphylococcus. The sensitivity pattern of the first line of antibiotics was as follows; out of the 19 Coagulase negative staphylococcus strains, 13 (68.42%) showed sensitivity to amikacin and ciprofloxacin, 15 (78.95%) to sparfloxacin, 9 (47.37%) to erythromycin, 10 (52.63%) to azithromycin, 12 (63.16%) to gentamicin and cephalexin and 5 (26.32%) to penicillin. Out of the 7 Staphylococcus aureus strains, 6 (85.71%) showed sensitivity to amikacin, 5 (71.43%) to erythromycin, 4 (57.14%) to sparfloxacin and ciprofloxacin, 3 (42.86%) to azithromycin and cephalexin and 1(14.29%) to penicillin and gentamicin. Out of the 3 Pseudomonas aeruginosa strains, 2 (66.7%) were sensitive to ciprofloxacin and amikacin and 1 (33.3%) was sensitive to to sparfloxacin, azithromycin and gentamicin. Enterococci showed sensitivity to sparfloxacin, cephalexin, and ciprofloxacin. Flavobacteria showed sensitivity to gentamicin, erythromycin, ciprofloxacin, sparfloxacin and amikacin. Their resistance patterns were also studied. Conclusion: Coagulase negative staphylococcus is the most common cause for neonatal sepsis in the NICU. Most of the organisms were sensitive to Amikacin.","publication_date":"2010,,","grobid_abstract_attachment_id":"68390370"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"The bacterial profile of neonatal septicaemia in a rural hospital in south India","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [60664201]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div 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class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">The bacterial profile of neonatal septicaemia in a rural hospital in south India</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="60664201" href="https://independent.academia.edu/HermanEdwin"><img alt="Profile image of Edwin Dias" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/60664201/27964888/26219186/s65_edwin.herman.jpg" />Edwin Dias</a></div><p class="ds-work-card--detail ds2-5-body-sm">2010</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" 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data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="111345120" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/111345120/Bacterial_isolates_of_early_onset_neonatal_sepsis_and_their_antibiotic_susceptibility_pattern_between_1998_and_2004_an_audit_from_a_center_in_India">Bacterial isolates of early-onset neonatal sepsis and their antibiotic susceptibility pattern between 1998 and 2004: an audit from a center in India</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" 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ds2-5-body-sm ds2-5-body-link" data-author-id="298641007" href="https://independent.academia.edu/AgathaDavid5">Agatha David</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Current Microbiology and Applied Sciences, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Study of Microorganisms Causing Neonatal Sepsis in a Tertiary Care Hospital and their Antimicrobial Susceptibility Pattern","attachmentId":116227826,"attachmentType":"pdf","work_url":"https://www.academia.edu/121317126/Study_of_Microorganisms_Causing_Neonatal_Sepsis_in_a_Tertiary_Care_Hospital_and_their_Antimicrobial_Susceptibility_Pattern","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/121317126/Study_of_Microorganisms_Causing_Neonatal_Sepsis_in_a_Tertiary_Care_Hospital_and_their_Antimicrobial_Susceptibility_Pattern"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="38738957" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/38738957/Prevalence_and_antibiotic_susceptibility_pattern_of_Coagulase_Negative_Staphylococcus_CoNS_in_neonatal_septicemia">Prevalence and antibiotic susceptibility pattern of Coagulase Negative Staphylococcus (CoNS) in neonatal septicemia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27377481" href="https://innovativepublication.academia.edu/IP">IP Innovative Publication Pvt. Ltd.</a></div><p class="ds-related-work--metadata ds2-5-body-xs">IP Innovative Publication Pvt. Ltd., 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: Neonatal septicemia is important cause of neonatal mortality and morbidity. Neonatal Coagulase negative staphylococci(CoNS) infections are rarely fatal, but they cause significant morbidity, especially among very low birth weight infants. Objectives of the study:1. To know the prevalence of CoNS in neonatal sepsis; 2 To determine the antibiotic susceptibility pattern of CoNS in neonatal sepsis. Materials and Methods: A prospective study was conducted on blood samples of suspected neonatal septicemia between July 2017 and December 2017 received at Department of Microbiology, SIMS, Shimoga. Under aseptic precautions samples were collected and inoculated into BHI broth and subcultures were performed on MacConkey agar and blood agar plates and growth was processed by standard bacteriological technique. Antibiotic susceptibility testing was performed by Kirby Bauer Disk Diffusion test. Results were interpreted as per CLSI guidelines. Results: Out of 156 samples 98 were culture positive and 58 were culture negative. Most common organism isolated was Coagulase negative staphylococci(CoNS) 48.97%(48/98),Klebsiella species21.4%(21/98),Staphylococcus aureus10.2%(10/98),Gram Negative non fermenters 9.1%(9/98),Escherichia coli 2.04%(2/98), Citrobacter spp 4.08%(4/98),Pseudomonas spp 1.02%(1/98),Enterococcus spp 1.02%(1/98),Streptococcus spp 1.02%(1/98),Candida spp 1.02%(1/98). Gram positive organisms were highly sensitive for Linezolid, Vancomycin moderately sensitive for Gentamicin, Cotrimoxazole, ciprofloxacin and least sensitive for Erythromycin, Clindamycin, ciprofloxacin, Azithromycin, Cefoxitin(MRCoNS) Conclusion: This study showed emergence of Coagulase negative staphylococci(CoNS) as the most common pathogen in neonatal septicemia. Prevalence of MRCoNS and multidrug resistance among Coagulase negative staphylococci(CoNS) is seen. Keywords:Coagulase negative staphylococci, Neonatal septicemia, MRCoNS, Antibiotic susceptibility</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prevalence and antibiotic susceptibility pattern of Coagulase Negative Staphylococcus (CoNS) in neonatal septicemia","attachmentId":58825644,"attachmentType":"pdf","work_url":"https://www.academia.edu/38738957/Prevalence_and_antibiotic_susceptibility_pattern_of_Coagulase_Negative_Staphylococcus_CoNS_in_neonatal_septicemia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/38738957/Prevalence_and_antibiotic_susceptibility_pattern_of_Coagulase_Negative_Staphylococcus_CoNS_in_neonatal_septicemia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="86523103" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/86523103/Study_on_Bacteriological_Profile_and_Sensitivity_Pattern_of_the_Organisms_in_Neonatal_Sepsis">Study on Bacteriological Profile and Sensitivity Pattern of the Organisms in Neonatal Sepsis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="113185050" href="https://independent.academia.edu/SubirDey7">Subir Dey</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2021</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Sepsis in neonates by resistant strains remains a significant cause of mortality and morbidity in developing countries. This study attempted to find out the organisms responsible for early onset sepsis (EOS) and late onset sepsis (LOS) and determine their antimicrobial sensitivity pattern. Materials & Methods: This prospective observational single centre study was conducted on 1000 neonates during January to September 2018, that were investigated for rule out sepsis, at the Neonatal Intensive Care Unit of Ad-din Medical College Hospital, Dhaka. Results: Fifty-four neonates were found with culture proven sepsis.Coagulase-negative Staphylococci (CONS) (68.42%)was the commonest and followed by Acinetobacter (18.42%) were found on culture isolates in EOS. In LOS, CONS (75%) is the most predominant organism. Among the gram negative Acinetobacter (50%) was the most prevalent bacteria followed by E.coli (28.57%). None of the gram positive isolates were sensitive to Amikacin. Ma...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Study on Bacteriological Profile and Sensitivity Pattern of the Organisms in Neonatal Sepsis","attachmentId":90955623,"attachmentType":"pdf","work_url":"https://www.academia.edu/86523103/Study_on_Bacteriological_Profile_and_Sensitivity_Pattern_of_the_Organisms_in_Neonatal_Sepsis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/86523103/Study_on_Bacteriological_Profile_and_Sensitivity_Pattern_of_the_Organisms_in_Neonatal_Sepsis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="99081935" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99081935/Neonatal_Sepsis_A_Study_on_Isolated_Pathogens_and_Their_Susceptibility_Pattern_at_Tertiary_Care_Hospital_in_Rural_Setting">Neonatal Sepsis: A Study on Isolated Pathogens and Their Susceptibility Pattern at Tertiary Care Hospital in Rural Setting</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="81067189" href="https://independent.academia.edu/NagaSriLathaBathala">Naga Sri Latha Bathala</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neonatal Sepsis: A Study on Isolated Pathogens and Their Susceptibility Pattern at Tertiary Care Hospital in Rural Setting","attachmentId":100263439,"attachmentType":"pdf","work_url":"https://www.academia.edu/99081935/Neonatal_Sepsis_A_Study_on_Isolated_Pathogens_and_Their_Susceptibility_Pattern_at_Tertiary_Care_Hospital_in_Rural_Setting","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/99081935/Neonatal_Sepsis_A_Study_on_Isolated_Pathogens_and_Their_Susceptibility_Pattern_at_Tertiary_Care_Hospital_in_Rural_Setting"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="31781770" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31781770/Neonatal_Sepsis_Bacteria_and_their_Susceptibility_Pattern_towards_Antibiotics_in_Neonatal_Intensive_Care_Unit">Neonatal Sepsis": Bacteria & their Susceptibility Pattern towards Antibiotics in Neonatal Intensive Care Unit</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58496371" href="https://friends.academia.edu/deeptisharma">deepti sharma</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of clinical and diagnostic research : JCDR, 2013</p><p class="ds-related-work--abstract ds2-5-body-sm">Neonatal sepsis is one of the most common causes of neonatal mortality and morbidity, particularly in the developing countries. Its causative bacteria and their respective sensitivity patterns are different in each hospital and region. The objective of this study was to determine the causative bacteria and pattern of susceptibility to antibiotics in NICU of a tertiary care centre, which in turn may help in implementation of empirical therapy. This prospective study was carried out at a medical college during the period from 1st April 2011 to 31st March 2013. A total of 364 cases of suspected sepsis were admitted in our NICU during the mentioned period. Out of which, 137 cases were positive for culture. All the neonates of suspected sepsis were screened by using a panel consisting of CRP, ANC, I/T ratio, micro ESR and culture and sensitivity. A total of 137 cultures were found to be positive out of 364 cases. The most common organism isolated was Staphylococcus aureus (37.22%) follow...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neonatal Sepsis\": Bacteria \u0026 their Susceptibility Pattern towards Antibiotics in Neonatal Intensive Care Unit","attachmentId":52083702,"attachmentType":"pdf","work_url":"https://www.academia.edu/31781770/Neonatal_Sepsis_Bacteria_and_their_Susceptibility_Pattern_towards_Antibiotics_in_Neonatal_Intensive_Care_Unit","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/31781770/Neonatal_Sepsis_Bacteria_and_their_Susceptibility_Pattern_towards_Antibiotics_in_Neonatal_Intensive_Care_Unit"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="43193458" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/43193458/Species_distribution_and_antibiotic_sensitivity_pattern_of_coagulase_negative_staphylococci_isolated_from_blood_culture_of_NICU_patients">Species distribution and antibiotic sensitivity pattern of coagulase negative staphylococci isolated from blood culture of NICU patients</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27377481" href="https://innovativepublication.academia.edu/IP">IP Innovative Publication Pvt. Ltd.</a></div><p class="ds-related-work--metadata ds2-5-body-xs">IP innovative publication pvt. ltd, 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: The study of blood cultures isolates was conducted on samples received from NICU of a tertiary care hospital at Ahmedabad during a period of two years. Objectives: To isolate, identify & find out prevalence of various species of coagulase negative staphylococci (CoNS) from blood culture of neonatal intensive care unit (NICU) patients. To study antibiotic susceptibility pattern of those isolates. Materials and Methods: Same staphylococcal species isolated multiple times from the each patient were considered true/probable pathogens and were considered for further analysis. Species characterization and antimicrobial sensitivity testing were done. The data was analyzed with WHONET 5.6 software. Results: Out of 4889 blood cultures received from NICU during the study period, 1465 samples were found positive (positivity rate of 30.0%). The most common CoNS species were S. epidermidis (64.6%) followed by S. haemolyticus and S. hominis. Septicemia by CoNS was more frequent in male & low birth weight groups. Isolates were least susceptible to penicillin-G (9.38%) while they were most susceptible to vancomycin (100%), teicoplanin (100%) and linezolid (100%). Methicillin resistance was found to be 26.04% among CoNS isolates. Conclusion: This study indicates importance of coagulase negative staphylococci isolated from NICU blood cultures and suggests that strategies to reduce such infections in neonates are needed urgently, to reduce their medical, social, and economic toll</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Species distribution and antibiotic sensitivity pattern of coagulase negative staphylococci isolated from blood culture of NICU patients","attachmentId":63460386,"attachmentType":"pdf","work_url":"https://www.academia.edu/43193458/Species_distribution_and_antibiotic_sensitivity_pattern_of_coagulase_negative_staphylococci_isolated_from_blood_culture_of_NICU_patients","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/43193458/Species_distribution_and_antibiotic_sensitivity_pattern_of_coagulase_negative_staphylococci_isolated_from_blood_culture_of_NICU_patients"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="53279566" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/53279566/Neonatal_Sepsis_Common_Bacterial_Isolates_and_Their_Antimicrobial_Susceptibility_Patterns_in_Neonatal_Intensive_Care_Unit_Islamabad">Neonatal Sepsis; Common Bacterial Isolates and Their Antimicrobial Susceptibility Patterns in Neonatal Intensive Care Unit, Islamabad</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="81141096" href="https://pimshospitalislamabadpakistan.academia.edu/DrShafatKhatoon">Dr Shafat Khatoon</a></div><p class="ds-related-work--metadata ds2-5-body-xs">THE PROFESSIONAL MEDICAL JOURNAL, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neonatal Sepsis; Common Bacterial Isolates and Their Antimicrobial Susceptibility Patterns in Neonatal Intensive Care Unit, Islamabad","attachmentId":70191350,"attachmentType":"pdf","work_url":"https://www.academia.edu/53279566/Neonatal_Sepsis_Common_Bacterial_Isolates_and_Their_Antimicrobial_Susceptibility_Patterns_in_Neonatal_Intensive_Care_Unit_Islamabad","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/53279566/Neonatal_Sepsis_Common_Bacterial_Isolates_and_Their_Antimicrobial_Susceptibility_Patterns_in_Neonatal_Intensive_Care_Unit_Islamabad"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="109056666" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/109056666/Bacteriological_Profile_of_Neonatal_Sepsis_and_Antibiogram_Pattern_of_the_Isolates_in_National_Medical_College_and_Teaching_Hospital_Birgunj">Bacteriological Profile of Neonatal Sepsis and Antibiogram Pattern of the Isolates in National Medical College and Teaching Hospital, Birgunj</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27823508" href="https://independent.academia.edu/RABINPAUDYAL">RABIN PAUDYAL</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of emerging technologies and innovative research, 2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Bacteriological Profile of Neonatal Sepsis and Antibiogram Pattern of the Isolates in National Medical College and Teaching Hospital, Birgunj","attachmentId":107290070,"attachmentType":"pdf","work_url":"https://www.academia.edu/109056666/Bacteriological_Profile_of_Neonatal_Sepsis_and_Antibiogram_Pattern_of_the_Isolates_in_National_Medical_College_and_Teaching_Hospital_Birgunj","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/109056666/Bacteriological_Profile_of_Neonatal_Sepsis_and_Antibiogram_Pattern_of_the_Isolates_in_National_Medical_College_and_Teaching_Hospital_Birgunj"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="38710595" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/38710595/Microbial_profile_of_neonatal_sepsis_and_antibiotic_resistance_from_a_tertiary_care_hospital_in_South_India">Microbial profile of neonatal sepsis and antibiotic resistance from a tertiary care hospital in South India</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="108820338" href="https://independent.academia.edu/KalaivaniR6">Kalaivani R</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27377481" href="https://innovativepublication.academia.edu/IP">IP Innovative Publication Pvt. Ltd.</a></div><p class="ds-related-work--metadata ds2-5-body-xs">IP Innovative Publication Pvt. Ltd., 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: Neonatal sepsis is a major cause of neonatal mortality, the clinical outcome of which depends on early diagnosis and initiation of appropriate antibiotics. The emergence of multi-drug resistant strains has limited the choice of available antibiotics. Thus, antibiotic resistance pattern of pathogens iscritical for both therapy and infection control. Objective: To determine the etiological agents of neonatal sepsis and their antibiotic resistance pattern. Materials and Methods: In this study, all neonates with suspected sepsis, admitted to neonatal intensive care unit during January to December, 2014 were included. Aerobic blood culture was done using BACTEC FX system. Identification and antibiotic susceptibility testing of isolates from positive cultures was carried out. Results: Out of 522 neonates who developed clinical sepsis, 64 grew pathogens on blood culture. The most common organisms were coagulase negative Staphylococcus species (CONS)(32.8%), Klebsiella pneumoniae (18.7%), Escherichia coli (9.4%), Enterococcus faecalis (7.8%) and Candida species (7.8%). The gram negative isolates showed high resistance to ampicillin (90%), gentamicin (70%), ceftriaxone (66.7%), cotrimoxazole (56.7%), amikacin (53.3%) and ciprofloxacin (43.3%). In contrast, imipenem (16.7%), piperacillin-tazobactam (26.7%) and cefepime-tazobactam (0%) were effective with lower resistance rates. A large majority of the Enterobactericeae isolates (66.7%) were extended spectrum beta-lactamase producers. Among the gram positive isolates, resistance to penicillin, erythromycin and ciprofloxacin were 93.1%, 62.1%and 51.7% respectively. These strains showed uniform sensitivity to vancomycin, teicoplanin and linezolid. Conclusion: While CONS were the predominant isolate, gram negative bacilli and Enterococcus sp have shown high resistance to commonly used antibiotics. Low resistance was observed with Cefepime-tazobactam, imipenem (for gram-negative isolates) and vancomycin, teicoplanin and linezolid (for gram-positive isolates) in our study. Keywords: Neonatal sepsis, Bacteraemia, Antibiotic resistance, Blood culture.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Microbial profile of neonatal sepsis and antibiotic resistance from a tertiary care hospital in South India","attachmentId":58794354,"attachmentType":"pdf","work_url":"https://www.academia.edu/38710595/Microbial_profile_of_neonatal_sepsis_and_antibiotic_resistance_from_a_tertiary_care_hospital_in_South_India","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/38710595/Microbial_profile_of_neonatal_sepsis_and_antibiotic_resistance_from_a_tertiary_care_hospital_in_South_India"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":68390370,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":68390370,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_68390370" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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