CINXE.COM

<!DOCTYPE html> <html> <head><link rel="stylesheet" type="text/css" href="/DXR.axd?r=0_2312,1_50,1_53,1_51,0_2317-HCSds&p=3566a23a" /><link rel="stylesheet" type="text/css" href="/DXR.axd?r=0_2214,1_16,0_2219,1_17-HCSds&p=3566a23a" /><meta charset="utf-8" /><meta name="viewport" content="width=device-width, initial-scale=0.3" /><link rel="shortcut icon" href="/favicon.ico" /><title> Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar </title><script src="/bundles/jquery?v=uFgEwkmfdwWoDMz6vEeIoql0PDF7uHxE-GEoIW9UY9M1"></script> <script src="/bundles/json2?v=d1Efh1-9UFdw-Pnj4VVUxViXmZK9H1kqbY_kx2U79DM1"></script> <script src="/bundles/site?v=Uby6LDuaSQ1_He97UGZvnGv_wln5mTgGNE3q1RwRMEQ1"></script> <link href="/Style/css?v=moasmn2BWK6Px64tnr4mMXZfX9KqyGOs6yBj9kZctxQ1" rel="stylesheet"/> <script src="/bundles/search?v=oKWBTbQ1Eyu3c78HTcS6WrXwgMWPpz68IXv5mSC3oqQ1"></script>  <script async src="https://www.googletagmanager.com/gtag/js?id=UA-221132522-1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag() { dataLayer.push(arguments); } gtag('js', new Date()); gtag('config', 'UA-221132522-1'); </script> <script type="text/javascript"> $(function () { InitCategoryIcon(); AddArticleSearchRecord(); }); </script> <meta name="application-name" content="ReferenceCitationAnalysis" /> <meta name="msapplication-TileColor" content="#bd4100" /> <meta name="description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> <meta property="og:site" content="ReferenceCitationAnalysis" /> <meta property="og:site_name" content="ReferenceCitationAnalysis" /> <meta property="og:type" content="website" /> <meta property="og:url" content="https://referencecitationanalysis.com/" /> <meta property="og:title" content="Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar" /> <meta property="og:description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> <meta name="twitter:title" content="Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://referencecitationanalysis.com/" /> <meta name="twitter:description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> </head> <body> <form method="post" action="./search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" id="form1"> <div class="aspNetHidden"> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" value="URfDJoSZYwV3JywXPtNrT8jhzRFwmsmtAfI+e+sGN6sqYUxx0zpBAaEkUNNzBCSFeOj74tKeIkX2LOYl+riwlCx4A8G0x3uBajyJe3sv70pDGPdbQZpP5013HSxrhICFjoUDGNnKeqvsnu2lLDZtNRSsLoeIW/4bs0oVIBo1M6Pp/gXQnHiJ3pqjfuvEBu37GpPQGf7nxdhKqLeQv1BkzIF65nKT6CNjZ9IthZTNYFVZqY6Iyvic3/LkLBIbXaHuXiln6AXddyaMTE7WMtDMBo+qaDPupRib8bfNBtP7DuYK+AnhWyQAKS+/hEs3waToHyDe2H83WAzPU+nrTuaBiNJ+MqjQxAsZ3uilo6otUFLTwxhV7CewGp/5dGsAvolxxqF8HQgwseDyF4/IeDgiuuA20eshGygwoukcgzzCJTaMaUyK7IujFVdJDzPKauLVsAOM7zyTMALt6PsbclK1/YaGL73f3Nvm+04DWdJ6IydHsAxu6hcpdfsX9Wk0OoOXNy7ttIKHaP70X3sssGZ18NirCeowaXd8SRXtv5oUXIkX5aV3CY13PAXNKVFd4e/nMer2fRkgYnHkFh2VVJaiI/se4vRoya6d5JzCdWTAhbBNOb/gtMw676HbCUoI2F+RtVyOb7ITokBRTf/ymPrGr3Pp/3r4kuYh1fPyd66vTASqpJtY0uoqblVjdIBZhF2a6TNFrat9nzXgy8fda/wAzoqspZN25CmNh5QJJKEbOHRV4iDOUBEKcFD/d/O6hH3Iw9d7+2rW8Lu38t9cw8SHWlh6NVeFm9rftjt3Uky9Pw6Vd60lVej81E7r4zl3mjoRfurteRwl8nqymmv4x/DGNiUhXneRjdqbn8NkC0uH+gQAuUOxCMY6FMZARxk+dRE+lNfJI8ZL7+32Xw2D59gvkqtMT0++eOHB4ciIBk9yTkOXxiZu2PhXvkPLAHrwOP/N5X14opVAwWUBOct1XVz/qZDtEY22lfK8D1W2E0gwO6vnY+H4VQA5SL7cM95NLxhqrVWQVTJHkYi+nI66bU6vIjgKzTkelHpOhgXrgbXm5n2Iwco9/RvmLhkDpmEex3pTjVH/HnF5tl6MH4X3mf0+1o8O28dzi7IqlzrQmMEoLFKrUmYvlPgJpNh/L3fGL0/kW7+gW6k/H1xKpZpRO3jOMqq9rksPMTgTB4K7e2MqvQdM4CC+J49vAFUHmpwLExs/3EhusCxA/kCDxJacz4NWHhpZVbKn7uKNtX8MwLkwGXeEzuUZoqIge06Ru8jD+nju+ClgsvFIErlkcRykG32xmfddor4nXyQZnZA2W0qA2awGUu4YXiKnTnKcmG0Ibgp/Mktf3/c5KIHOwv9lgQ/SqvEcAy28KZqiiArpo0nwc66wYYLFCovKknzfoXSHKLb4If8z8acxTIl4pZLQYuni/9ALKS36kZukc8I+KOdHWWq03sDXOLdjxvN4yT2pV9OvNXCTUrkql2ozm43+XMHveXbLJkc0uyTWTSyiY2Ek3NnsaBS7+f8X5DvYe6InuoTCdo0j0DhEdoiZ3hfuVbIn6BbYYTide/RJjXAO3RIVvnGcZ5YY25FPCiKPNU8r8R1Zq1kanXxMeAVUmgL8cfJ7uvgD+Xzk4VCN90B+oRGVWtVi/sD/LUYiyZxYmG5Exg7sZkmRYrbH5g6HdQpciM6qjaTg70Qas+NP985z57vjZgXIwOHzq8j31TVgDacWEvVcooUPFih7q1KKOK6CKtgZMjR0ccXQ5I1rWR/cGfPjwH/apN2scz++FSTD0BY0Jn/PoN5vXfEOF+Jpj9oMEUalp8EFG6JG6HsqtbhqUk9jXOVfzdkSLDtTilCp4RIb7DhkCpp7izXJ/qTxp61z8Spdrosai3SMHLJ/umrqOCc7vAePar1OJlckh3Jge81qycRdg0Qkhiq+HLzO9dBYbm2i7qLEx8sC8m+/vCwGLAgKF9ldXWaPEche5L4sEEQ1IsPtC0G1cfr257/kXWKWEvcCwzU/CNmVecPxWnlpnT9BGHCMiBII854VGo5nKZns2UgjXD/oOWs30GrVlmMEEy8uQVTPbsJ2TK9HaleGZj1//gBDMdIfQfV1HEocl/DzE4Vs/HjSuYbpljukSB3A+IavCZ9Rgzd/RS0cxkWjljsPgxbvvniiJ82NimLZMAONwr2Y1HTDag2DFd5KgT3gBYnBa/AShpqAXK38F7xUPuBoPcZcTrBr/E9cIaJC72IEtnUgHdfWhyQ8ki8zkLeokYwxui/nnf5xZeF+DQ8HWyhy7iUlTvsB782jUdDrPOf2thSuDqJtkkXXEaP7bEE7cP1DQ8dEsKV9xp59vNF4w6qteGMNdgavvVHmMn+OmVRLtoXBwo0PBZ7EdSrdDkOBd8WZuVBHSk2nbUdr6J+lv4yLXaZHXaoMkQuERDqgEv++tFphmaIY1JMxbIBd2Q6bcXCkjzY7UBd/XjbbU89gjzyEUs1p+kVQJ027YA7/+CoUMFzgsQxmK7DXvNLAJICwWhbwHeZjWFKIGCb7IdMehh34jL4SJseO0bVFmgtxdm/PrJ/AOUoQLK6GbGLj1HIS8yQbsUqTMHRr4moNqNU8z1gJUruFTO7y/AziFWqGwZ564scVFfWdz3QAhs2xVph08fLZrxFuqKXtYmqFhRwRBPoi+/4kbR9H2v41O4p0cs0ImszOKYfYGuyYUzl/x/7A6NcDR/Ona+R3T2i41gQ8bIJnNtVpzcSKYDc2k4TGWRGNKmxcJdeWQLik5ZWuvltnEF2Z5dOrOEb5mNRz6xG5BeTTFDPFttkYmaNl4I/lr0yXmTn0eJykVOU3rsvf+RRH/2zjFPmJrm54PEeRcQq0ta76J4izg183KxoUozSvuWxirV7+ZyLQBNNpGMxIoBIkQ5el7TL/BSS4PiE1TNEQnKQmqYQIbeIzqmW0q/XLjx6hvpKtFkRdRfAmOTklmE/flpWwQWKW6NM0BGA2e2Nrfm7q4IrTyfW4Ig8XhNbY7ejvi/mt5ERZfnmJOhcmXKPbk+6Qlp6+Garf9xmdnC/6mXagsXHfoM3b20dp2FCrjT7V76N2cz6+PNl9o3TQvPqyJLHwUeSAR7SYqYqtGkzquNmCGfehy9DnKI/ZjCv8YmvNaeLBU4SviptEZhwHHj4jpzOq67dna0EX+ddiaf3rCMcwFysQQlNLL2KgYpubiV3dExYFzPd2JgcbC+89MYPtgJrIq1qPn2Rb1P5d0ZZKKvBcr58/s119mrZWi8NchpNRLxNetLwIeTbeGpvulKHJRB5kSgbTa8MWkWQhnqbiPfe7rwZdBOunICZjUB6OkUo7dqUzXbEafTroVQSIjLj4QU7dkv6X6Q1uMLIfT6kQC81Z712eMS8FjYEwPVLzqDEapFDWktiC5uOU0KINIqxP/wdB6eFyO9/xp6L/fLhTtrmOlNGxmu+sBGY2uHmTkY6OtjFu921xZ9if5WXdtx5OEgnUQflvxEA5bA76owcUdSdcflK7U4I6ikNhU7Qh7WdpQQKznNPYjlRfiJ89rdXqUuIWDZyyJhqCy15U8Qd3aS3ilc3avSdnh9udJ0bqC5PIv4cDtO91A1EcEBWh5uZCDQFMtqF42JGvMjSazVnPebYdENAPoTc15waMADdRF+taMnQxJfMaiah7oQxAfpoYV2kLiCm/5ZCFmOAgE+9Fn7RHHw5oVTCJ+TwV/1fdoYl567zQfdFSQAzae64F7e9890JpFW7kVSIhJ77VMsn4fz/jNwt87EGHUHJthurKKukJP+eukvcQ7NYxfURMqcYmkf6Y6U4XanUlrR0zLlp7CBa6zrp2ojW/U8c13C9S31d4pq95D5Fm5kayL0zacv521tfTlM2I8N4Xg4Fw57dQszHCk1t4PaQ66MNdTz1Z5IoyajA0Ewkzf+4xUEXv2D4ryAf5TIBXDBnVQ9i9zh8mvEL69E05QCGsRe6/3FqVJJHXDoHhkoMY79opYh90FWcJWbxAQJqOuhYjlCL2KyUJGRTMnsxZKwZ3/BhCu9Qg/cfXOr7o+rMJmEAO8st6z5D75QPmtGO58yf9AY1yCcKcXbLhLrm9c4l/Ogzd9p50gtC72A9x6HaTurHhWa4jH3ARlGf95FuOQ9hOtjOCSfWGtPN2pPkdNyfAiEkuw8Yo9wTs4PLmZoV7eldGLtqOexm987gizxaUppWebxbN+XTee8iMlJJ6JFQHaTjLrimUcGGIkFCDOz6LDwaYG62YxSoaq89ohgN4rTjrE4945HBYwUZH6CqJr0L0JcMFFIQnhucmLVTgoYSPWQg8ppsOYoYIzOvVjbBWrMS8D49D0L1d8A0oECL6+rZjwuuzMh9fbnaIXfXrLdmajTrdUXCWoN3XUn1M398r8KKJTJoLj7yBGf3bjHlIzNzylUdNfo/G7E8zx2lMy/kuIS12jwbrkwu6KOdbbBxGfi6xDO2B+I1D1w04KkZhoQ44ewfOrGYwDMaN0VR4uXauPrh5QRFSpUxzvb9zW3i5Gwr4F/juwM9B7MXGtHLOGkKHxtQ8EKf/oL7T4ICO8I66xk885ntshgziG88R/9VZrccbfu+apBzIYpkusT1llDZ65cjCgh99wCileJ6NH95/wwiWt0j8HdNTt9uU6jihsR1ZUCg956M1rWw7jpQ4XsA+Obe3dpVR7NHyrDEaa2IysHs7k14fLk/930uNL1unWCs+k5QRgT4avOv11lgJnFwWqeFD+sOPhYLEs381f+5a6xdJ4jpCAf4wRStmsfOOvaPdMLNOTsWiRm7SLUwY7VPfkUzh248VrFYid8J/EiRz44xwlNgdhNoq5M54Rg80aOs9vfswVVF3dyWa5xWfBJeVr78aA0Btg8zMk0vy/tQIPshbJyHx/1t/gDAu6ARwE/vdGQDOf+wxDBZ/uYJQ6hF8Y6cGdiIzIaO0EhFc7MSLOJ3xz/pJMz3mJt/GHsD7SspQ7zVLhe8UVedQXHUUI6GRWLVpvtJc3cIl9mNgVsPYkvD3C5pkNiMoSyGXtAuYv3Cz1IXJPtgXky353H6XymUsLbi26CVYQBsmNOj0YHTlIxWogYjFoCoiIqtA34XFQshEE8gVaRnCyH18Tn6cCEAw+yk4KHiUw5yQwuG1YtRwhrqZbb5bP7oQYrJHHVRiwtxSy7O80Zp3XqiGevZkI/hGRwGxLFcia22BsPWdHkaSzZXMUAfIKEiQ6pKcLm+bzp0PWKQWxxXZADZ1vA21Vhar/d3EPHvSGtEjYIt1Z3gA0Xxr6Lyor+kTx9vyXCSqAm0iTc1IbtDxguQZUxDie+8qmo1a35U72oReiBXJQYL4B/95CUr0MswZBmnvYLs6NWzTcaayEgJKQ+IwguRiC6397QACNmnuygd78aCkB/rpeIbN8H0ZXh1aJwJlUZJzAxZqc74BUPNt21rT4QCz7ZgDSM6SL9LplPTzLOCtH1hSZO+zzOsb6HzIF54sYrJpsaBpB5FUcgFDR+noe21ZbQG1kIA7LIJQXcXSrCz6xdtkGlwGWH5Fi7cUjHKPXHEGwvegJU29tPcWVI8qKXzd/2IExfCrSfBckhm8m+epY2Q5fyu9Yrg/TjvC1rg9vTdTClcjIIsi0ltdi+jb3u13AEkpgyxKpyHKKW9Ccc1RdVZmcXIubb6AFHjSDUfwUBjLp0rpv5QIffeu7FkDBy5TUfwWQoyTGV++UrV8pACgvwckngekNYZcWnkRG8c1GNwkTqQsBVeEedW1bvdv96Ln9nokYTJCvkU08PvDiCiu90y5Q63oR2x+TxtOJspv04bl7shtqwvdnA/AHYXUBS+Y9OX4AfCUI5y9pe+Ch2UNz3uqpk9irBQTSg599l68XRb6JgfkqTJFxqPl71UB2XVCHRLhshV/u68B0eVT9G+3WrD7wuosIvSyIVNxLiUvChVSJzB+uTzpdaBth+oK2uOjYMmTs+FiKjW15OtHD/oDc8WIZH3g33PRviGC0Z1y+VFY/FiXvPesXWIBDtzmHlaUf/N0PgkLN1gkHOzBjUWvN/iOkegByHo11XP2rEbJHkT9SAQDb9HePztXz8CXAF+svQ9opf/O12pAcEdnkiB27/cFoOo4BdNs/sCKV810rB0WO3OBy2VTHHlGOEXK6A4obyvg1iZOyMsS+NrYMlckGQXj57hI4yZFB9EJQWExBQPNbt00LyQzhmiX7JyQb73y4vtBYZSZXrV1bUC/R30F+3xBwDeniwxsQ+QrirosYNtIPh40Uv8ylGAvBS27lVjpmnQHlP93JRF+A54GYt52fLi+GV3aO9/iGdxm+9e/Y4UK/qlLy8gYeLV44n3NTX7bWGdBzgpsU/S73/bZR6tKX0+7qLpS0vzQuLyUqAPWGSZlQwftP6gH9bxhWDJOqvhuvuE7xMoPlIXcq+oV6DvIp0WkaUGi2hzcADPxz0bY3dxl+rsgMGIJgK1OzZbZkUN4MLHpG41Lb94fjQWAiN3PbCckWs1962PZayGESu0/4iE82ZyHmESn6/PkDvzFigBssCXsC3JGkoQeETFY07QkHkrWxN5TJ62erEy2XNsapamIkGjWZypX8OndhF2fZUayyXnW8Dm6wR1m/HzQCdxxSq9KILtVYwFWPtDARlD6n6ZoaZo1D0WqY7qIRjXXiobsvhxhqkss59ZCJY+9kPsGuZK9OTObe2qNFh5h8WcSE235lImR2/La/blF9WtcSFJi3RpzsGztIbmexbZ5oEvETbe/edxOBJNVrTq2aIw3ZtOshzw1gGdvKyvMyT5YGNIYidh4ryFKnFvj2C8qOeohXsRU7Bc0CHVwAdjrCFjuaHK9p4UdAoF2Yw2ax4MnMn3Qp05srHGJ+rc7poY+rCm+lzIm/05u3duWGjZCL9q0ClmkqVYRGYtns8XG1kSG8HkqSjNA6KMPLVsXXINYCu3in4cHS5BmOgvRB1yhAUqfSlc27Jk6OHny4NQc98QgTeHKlvANCGUyEYzlDlWvkd0XQrs0/3tgz/tNw/wLa+7NjfTxU47t5YFcazv4iF8fOsItMimEK01KQYs1G8xjssyZbJZvIHCsKMSZ5TxWGyHxsGTs+ASUMVBkaqWGfo6PFuifvj2wOWWSWIbt/sfvfkcXmWrYiPgUHuFxmtH4SBeN6nv/H9sNF7e+F6s3PKApvCx8SC5gkppl8eriz+O2pb3FCYT1jU5FWO/sXNmQlPjvBPQKcOn7de01fQuxwzPtM9uG5onCnEBh6/ioTaOgbhAlQsKkksm2/5OSMRRONiKZ1papRUOwrKkRubVFQI6MX83BOa+uZJa+DrQ1paNgTucX4dlCbuGac8YgmLFIcSimxc87lGpPds1z4j6Mps5ShwrOb2g7cfjWaFzasYM3tQg5985PELciYA6qMNrI/BjbOWQeyKRmo6hA4vBo9EEbwxVOCGZz++pgSdNga2i5kdJ5afIBr6VfACVHVQm0wkuyy0VA/20Wm25h44yQ0pmqMHTffB7tnk723Rd5/GVPYl3lrDLuEzS7bSNsNssNEwDJsBKFeBwGvNAhly162XRpAWFEjery1LJ05XKH0K+v/wPKkSNEz0cTcGbu9AWN9huxrMoCHs9g/hfsaOqzjIK1bpZ3k9WlRkbeayynmwzL7D/kDNZ22Y60nNH9ZsVLTMcId2BYUisKAW+E1B/YD9bnbtwrg5R9Eb8aAp+Q9Od/rDwRI8uF7EwcclNiLsU8rG2MSwxYHEKmHUmtfDlxyFdhbNxc6FjrLgT0ncmbFUZNfS7rzRl6dwz4ZJS3gYrxRZnhRqvyDuRf04igX0MtGMs6dq20V9/cMZxqxFf8zwksGVi+YftTO1xw/n2dmY2PxCndlNHLicuQ2CEhigMQUuZ8o7yL/nEpBDwVJdRHiqdFuwJK/AmgCCU//jK5hryLuh+ISmXnxr8rVoapxlDVe4kiFU2thQkVHKDN9t7BxYdgzUEp+BAtJfkICcjiLkMXIshxWQnqZadMcVX6zIitWkwmMJnqMW247SPi/t7jlCfMy/Kx1HCo0Q/c4YTphuXgl/TRTCOLcA7YHDmdb39rF5FgvoroGuUlDct9CHeIm5Uu5/KPze3F2e5lNKQ8fTM+Y3lTR8TuCKzVSUJDOrOSRgEd6CLJZ8vY1vHoW589YI2eDmdGAycRTIwE9pDD5zQ0tBhv455IO99jc3RGtZZuHZ8NbGSxVU5fZ3PEAGPeAP6H9KVBkTwdPcNkZ4geC8ljiasqWJwVzxSULnzQwMKeH73W62A+EXNmomGG8WqxPRZRmTRuCxA0Ddg8otER7Mk3yVcAwJ5WgZZyMkGgLFPDlkieAS+Bgv384HpwLOaIgMFLzUao1DKeOGiFAWsxER+NQTUhBx4HUkrAV8InVznzWf3x0oRQBwOcLp/huhWI8HFlmzIXd9BIpxiWeOZkUq+1t0xwmTYnAPaGHMYqobuR3IG55XIIX/YYWF6NAxy5mUBQ4dqH1tl71a0rsyVnAr53Rky9er1V+4jF4Eqgb8zXkV1uJ/Ob4GjGgBHzQGKihCmFCjsxb1hXoAw0aInkBLP4/+iNoBrEB4Nx8NaCkUnOCTBOqvlvbXOZ57HcMkoXDtkXh5w3GTxwvBpSvsSKxZ2pEv1tdVXq2SN9b8t/UIHW1PsTxHNuzN4wtkoXm8Ed0mQg/1lItPfhDjYA31r1drEarr/K/tdzHEdIrD+IFJKe59Wj3IGQrOnvAcrlsE6H2vsPVbGUvlrsCZpwEwfSAlZD4BANCnxP2nlapXtle/O4qNm5b80bkKUjjeTY7WI0ACO7i3z4sJsfLCYtzJKany+lQYO8kFx9WJ+DTh2qfGPYjgDizd5aVYv1g3QCPW7K2Uh3fl5RnxRqazkCOwskcMH7ipwKWLiO0r3oCQExX/cDY9NFzEoH3wEkwXqUn/TdeACdSXGIziap03kipa8tWWdRufK3Vla3a3NrTwom1s3jTJQKni3mF2p68i6UAlN8CczhLUzyzG4Md5GyahjrUnw5wLrjClRPKpvHHbDQzJuJq9gDDsfdNfLKPKLfPh1maIunh2Vjde85qjeqg7gk/+XdKPbHQ1GjbPuWyYe9n96myOKqrXYnomAijZ7oQhVSr6LEhccDjuOhedQxyVFFMKGpb6J/knjIkSmRL63A0ej3EAQoohCfmcFbFG/bDx23d5ipvxP7ou1mOy32rnBX46RitF+S0Ko6qgEvVzNtlG6JHixuK8EM2xXnW+zgD5rLOT+NgG87C0oeqCY1SCFbqxtjl4UpK1YyyxVFaPjIrHe5BgjLWU0gAQGnW/rCL+xUi4nn7xt1D5vxjvPkOjsf0dWFRAgYmLxguqbb2AWFdYrvD3PXJBTPMYN2/VLvKgrFEKnYop8inW/o3zb429hrCKH7OX9Wtsf1IKP2MF2Eq/oWFmrPSyfgeHBIlVjtrPLgyT2VKcY4USut/2ica477IGeFl1EZUn3ldiKaNT20vHXhU+SnA6jla4CSijouD84AR27WlyPNd6VpNrKHr7ovqxQFE1V5J/l2gd3ed2lHN/vUSrd6PWWnnKBZ8N05obDGnDTfEoOsQmaZ5v7PqqDKTl1vRurwJMWNpZfRLaDfJPRILy9cq/ib7hJDkb6I2wu9OpX8CZF0F9npDk9hR/SLewgF+t8VBhzcmcGE+mrTdczs4qi1KWZ5/myfjShBqBMNIXm4Ppb8iXrxYduWzY9KDNXw7lngrHNJbpMQdFrJMNHTLUmJ3rrx5z8CvpZZ1SRGAHmdFQ/FJT2Vn/BcXMTr1V8BF9+Yk5z5MWyQS78SSedwodpbN1T8bK1wUSU+bs9+B0lZ6rkMCLBphvu8aL6oKxB+Ovjzz0i26uezpN1P8HIpAS4pjpzgvlZ7mPG7+SiK7EYyfZaD2fHinPYjE8flpVm53iGGj0h05B2bS5pQrx9Nv3dSeCA1ywclT+RogF08a5PwofY/9DP3M68MxXAo/cNsHoTtfjEew1qDFgANXNvb4+5ZwBNHjW4XydhlOhRcIPtN3NPyr9CbW16PVqzE9Ay8jVFcMTey9KgtlSRpZopw/IEkRSBPJ2/GJFYgq2ykAsIxn4mkdnx6fPDxhawgAdiVnBx+38mrfqsavmmE6SBwcpZHKv0ETJhXG5/8ZlMKbTPotAsdSdOxDJKV3S7BDA22KsuER5pvNe+ufxQCN+jRQXu6HFgWtAx8Vla+9HR1/0F2wvRnrwlEdYz15r+AKTglp9eTihBzOlEILlfCjMI9cAuqU2nCN2hMeV2I9WUwmoAissiPZMZTgnl2sSLNvDLKtkqHJ6dfbaH9GJ7UAcCe11PRLhhi9OKtT8+vFuYgfwIMz9PYkFgLW5BtQ5ux0bM4DEcP8loiurLSdvEEB3XGpmkoPpoFqQDai82mYlz/ancZfwtgU9GTsujsvPwFEm96NBpTNnMhRmDFRboOQJ+vjUlXmLdOW/cdC0row0tDclgTJKuzEMjAQC/I/jN1tJlWHFBvpqeJ+qHibcZ46/rKDkSycMAd13xujlZ59NnhGXUUxDXdpbdfLJjqKkNInSJQDrIcfA/9DY667b/XtV9mtJInwi30pg5LWbepfK0CI+pyFq/PSMvm5MYecbwpLxyg3jQSmOzv4mynj6Doc6F/ATEPzED1ggeoYhN7+NIGNwmMyZyFssAGlU61tDWrc4lX+IlR0V/SybIBYfVbsruVfJjnj5CfBIktWEy+IVM8Q8KPpqKXGI0I487//jYKEomlejEasedYUxC/w1o9vDEHAp00VfDks5xxEgTrLp42LZQ7E/1rFuUtRf40KjsuguwwlhidgYRz46wrvuwjZTaZQBS5RgTXybNZv0RXQCTwMmFC2Hn71oOcadTu6ZzObBH9wqlK0wDJ/K1ElyAUk7Ppd34o1q+oiR5s4tZXhQBi9OxduJTlLsXvcK+1zsqbw5882fjX8OgSdaXM2ELbxt2loQpB4MmMb7cFoFi3PiD9/GXoulvFBgdlGOnYnPSNSTuzO0y2WpJSyfjzpLAPS2g195vlT/Xw1vBXXiK+8GEaPduWsuxYV0bMxAO+xjOWPKPK7hJgVMoOubAswKorNVU1Sdmi0MJ2t7eUiBZ6MTgL9ACb1s5SiX/e/ryr5ttLrOeI7f+zMuyB5aRVKE2093LUIRifdgmxjE+VfZqyruV5pdhdRyG4alj4KoFFIZiF+cpqEznNY4OXbx+/XUgg9qR28HUzndJFrmqTd1x1EnQSQC4xMPpeHtm7hiXq1immVQRIzyOPrZqO34gtywOt3IwbQc0EHLiLQfZqeAer5jiI6RMs0FohVOXbMGgPV+bd3JAJ4AqsoHK+XOVbU+G5QokIxcFoqz3KF+0n4xVUn3QyuBtpTz9OLC48VNQONQta5xG9NlLe0cHRDBWUtaCsdFeoLpMGGooCJ8VOKVvAPudQ3v02Ksr3wOZjwd45e4eiUG1KAWbo+9wgsLcwaYRklV2rvVgLxU7huWs1CYGixYO5lvSQheg3iD+FhySVW9BgmBt1ohHGDBBZq+dskEACkNzp+5dnQSnRZcCUaIgrDJcJuk4lYOYOqRHaSsyMx2vIiRkyrkyHsHeHxNfdyLnpFA4V4X9tTbB9IvnFdoUnDwqwa7SV6gcaOD2GoOkZLIEoWjdc+EAoTee/3QsETvSsHDNu/GJ/q0L7Q+tKfKwEwMBTxsnfhmE2Zftk8KEZc8E1WWlMjBN8wyYzi7qZWWrG8A0NG4S9ISoAw1D7V8bFvsWxVmV1eA4jba4hHPbCpmBzZ/qoCkaFa4q+WJpC0yLvCWJtuvuSj/miSJFwIAitxG9DVzx4s0sV/TRGlR+5FikE8pnteTzVmrusr1eH3i7jLRq1/an8DD6fTAi17npsIgGsFJ557L21CtMhujlrtxp9B2Dlp+b6hRGIgoV3OI4hGRBrwDGQB6SlliYJM9EhsZ5BV5M2SkbF5CctCQqa087lyDfwfS+2tDCu14XlKIr0rYAA8Fyzjq971NcWRpv6YpkPMM+Jc904/3lRzUENkDOrYR3EVusulQ12b+JfwiyV0/WoBipwMaGA0TL9IdFtyqkoUgquR6nnz5syWGoXAEqKF3DyUZLiBUHhTfltMGQOPigDDCVt7UML47QYaJwMcxZ4mYqvDxaDQ+BA2h2k/l2T9UCnF3tm6cxaG9sgiFcbnUgeC7CTuuGLfR3Pa54CXcJfyalhfJ8N0xZAOajhgblG5UvzfsOIcyxPZNXAfAxDByqMZ8CgX5AiOkEpnnuAEnd0mQLcPvBvXgGqZO4CTHIkwAFLL6P9XLWMK28AiEo+6MS1x//boy/YAn/vf5IOMHwsdRK06RgUd3Ioizw8OzmKJ7N1rV3HKpUYfgS6Kd9W5soMAk9w6aof4iCpoXRaG0SRvfbF9WLVVy29Q8pcZNx3LY9ylhnr7oUPyZTgOkAwkRPl5/zrWsnQJoqEFu5vbLFjmh0Rm1DJBL7ICf22ToCcEavxh7htuz8kFmQWddp2KcXPGxWKvwuI3GB/o0U0M/ptCI/r9vyHo0pJEseKJ9SSCleJRgp3ZyL5wvwyw3I1+pFvZcIPOi5m8622pkCdEcZ0Iz0+UK9K/1BN3wEuCkpAvgMZPgPxDc9G8xVgzCt3CVbHTbg9gTqe0UJs/krUsaaKFLnCjTsbdNPMP5ofud0UGTHNYI475txN2gMFPUzQ+775QDxu7/D4VHYh4odaYqgFbqVzvEqkj3nvqjfTydY8YG1dJ7NvG5Sr3X78n36Nh2h+VOeiEL4/PwcWeifoN4Z6ZWVdV3RL1qH6biVkzIOnSaFBfIZLbxXkg/mo1QnZohcMnEMHIa4fY/lWsNE9fNix84nM3S8BfiBhT6qON5kn3UXzNSzI3qTpqmGAwsYUoyOUj0qKj0V4j+5lYOs0ktPyr+aKILSMZX3yP0b/ulO5CZiHl6QMbd9glseAET7iy00mlDqxV9ZxWKunPOMf08l2XuYntIEE7Ylhlnw0pSCj1pu+eT8ofm+KKZGf+XBAKY6WZUpWNg0hq+5Q0yv5/RQ1euQ2MOXQRnXSoiq3TY6+ndKR/vJZN4lkAUIzkElmUnCyjFMz8lZBLVhQNqILvdnrmzCmgBVyo3xiWwkcBfY1hoGJbpmHTrcZuVTAeLWB5MT2yfF4wnpMJO3CaioZhUH9JyuwwK0pvI1j1CQCryO5qAsNJsTQHHGRIWRcQ0GXdJcz7q4rQy6FtyYjSpFpqPKwwj1WeRhFCRPphQ7yCXCiWOP3FRDzI3Gtfz/D/hGQAKAQK0TxwiSEc0nRNCEfX4yF1GFI0RhJ9hEGXXgbFweLS2OLb81k+BlaxHoFLRK8x9A/NInKLKPKtDk/qUVi/lj9yACS7kQ6djiWGqIKCtPgTvRDCt60wBHPZa456m/7SxiW2GhMK7daMGgVePn79dsLLBoqifN3S/Q3rpBJe3nyjv7LEAwfOf2PY5LbBK2d1LMusJC55tTCw8MkRFPE/0yRwBEvz1Y6VVjmGNtGpXZ0MmEnVBiXor51uN9or7sVdjScCzucOM6ECEm1HqTelZPWnVl3AUshLI1B3rUKRrsytLsy0m0Kgc65bIqmYrnf81E1fZ9C2zfdrSBbav43d2f7foLpx8HpbkkZS2bUtJO6RXwO0Vv7JNMGVbgdFnNBngbjW4VzO9fISsIWLPRGd/HfVUEwTCLu1D1YSI3X9CGCkHCpAnHYh4VANXWo5YlIMcb9kvFca0Gr8TT+2pvhR6vuq7nCkxlfdhu0v3JngJc/Gls3hJSrAK4p8T8S6QMCBz4ga+1iqBPl6WQcgi8pApu5mZ7JgN0+InmpM169o3UhRZhbA8RJMD6Y80UBD2RbQ2128scw0pzabAaHt4CIzI1/JOlwfOS3JSkl1lDcax2+K8XnBiQ7lBCjAKXfoKMD67hNG3cWhzpDXNPRtFEhVhtGtEvKL2IOLwxNeCsY+5mgoZSdZQWwhm1RP9gOwrMMmlS11kkFZQSB5+vb1vdHqHnuDcuXn2pQmDLMvCSYpXKEFjIS0oqz4vx+PJO0JaN2Ien6E/vWuMl2Nyid1D1Rt618ONtohMxAwZ0luqpkqotQXaHbAV3ZrPiy78Inuks6rpgcobm2QU0VC0NeQCTulPV1a/ojlJrgtVPyC1nqtu7vbSVhdCGDz79Q+Tf69DaPQY07VLykf/AGPdtVQ9yPlxl6EZqe91wF78hkOciioaVUaGjv3BQZGaB5JeMHpjiYtiriPVp77lkddXcF5eYC1EVIN0LdWU09roVN5fmvykKwE9vQf95//PCYGNWdmtINausfg7K6njaxzzqq3z3vIZFVGmnICqAgsBvKvD05KIY0o7456Xm3MCa/rRfZzLyBer5KHoIqrz4HrZx2Y7k3wy6S+5iNUAR4GqnNnpoHrenkB0s41MPwGfPA2UPl+toCFMaeTPwG0x4gO/7Gmxgq4P8AevuanVkr+yEZbn7TOucXD26+bDUYeiW7inGsRndhfMA9jl6UPEyYpzVhj9X0DObgVgUV6kbAn+MEGNNzzQ8gn9C9qmhb+KTi9oRMucX+3TF6WaRCJRSF5Zuuz7UNlC94yYWmmLV1ntwjYPjQNTyTyeWEwU7oM2O4xnH5joh6z9OTXuNbzYcgrw9/i4LjastxX9tgVMNYZvoZw0Iu/FfxKsE8N3I2lwmwXIi5gbBHCZZHUC05E5PfVjrjivXXgC0SHT0rkC44dZZx2FXBUjlcbZ7DuLBcq3IWmlg15qB0P3EkaHFCgqJalZsLfwYwlc0Niqr/A5h3lctNi8wkYUCGLejHiIXJ+2rzpxQfv1w8lCXaTzWY8J2mQO28VLtMwVyHqVp9lC0bdqE8QYqZxmu5w5D3uEHVJvKA3dk8oruLwZh6oKcw+d6UmTm8o3D9K9Y9nHAyGbe56c6UyZpnN4W56LN2sf57UBHtqMj3KhrFAdKNMiR2UqcFN9LmO2VtsbgemmPkREXmR9GEY/1EzBgn/Dc48xlFL1hrSjQY/TuKEb89X56hFdOF0CmxOF7+jeQIzj53/75UhwsWc6Q68QVSKU9PnbFJDlMsr52+JRNuXDME/qgAHIONmdfJhusLJ0GOmXAA0aw+35Oe86GAeWso5NKmHdVF14t72jWsH7bCt7kHxSVwYsXuNEXdNXb+hvXG0VqMDu5gTl+MOW5VhRd1hJnrj7gPwyMkTvicF04nYZcmYm4gs28uUVD+qSUej28n1uXutf8YfgUkF4RlwCqjMBz7Jm5KfQyAjdhdeI4spxZLSFaF2KO2x8AI4MGDPLyujS2OmrR42Q8SZzWK1oJHEe/cASRc0JhPBI4YSz0vLpRzpiXot+ozuISpyVZDXnmBOcklgIxajbPvcFZRQg1o/Ajh0fWV5Ebfcu1xSm4yCgUZ+V+FKGEgcU4yLxhTjTLFaVaJiOEUo2h1Mi8d7f+SLfWOb0dd2DRk3Lwk6+qyD7A6arA/bi73q7W+QOsU40o0Qra5eF2I0YWj8OF6z+2a1D+HtsroTZsMK4Y/rG07l81u3tGhPO6p9qG+ZkyF/R0Iyl89by07RSo5Hgv331mMvvwaASpfMpIWEzMqQ+t/alOqsT3fVfrYo/OGAzWa/I4In+ShbKyj52WCNTlIqfzCWSnqnCiAQiXoQ83k+pd3eZXpHczVxt9GfLemcWLHrZP9nc3yJLzCTlAku3DaB2M/5I4TDo4yJIsaWGHaNyQoX2VDHvGcowxdwFWr0Y9eSRH0GNep2KwLxVWzk8GehtEJ3mzpkt1LInAkRobPWHtSEmDcuO9BdMNtj7e/PR2iVatWChbMQ6r3vNfYkSFyss8LFBUl8qkT29RSaCqNrJlGA0F9N5DbKWfnb06z7Gk9gXoA6YkfI9HSTVEXvJqVoA46cAArigNHWo16AIx2+AXFmozem/p5VqKg7hYoZkjZedTmnNZ+dNvQancch08ddh6Pv2c7AKisoVLGefv0oVxqn9ZVd9BySKRbYg1GtnDD4TOZcqmxu9wUHSoCJ76b61S1PRc35I4aywsadiczSXTV4jgdqEN7hbuGKiYMAsmjD3dtpfkCej5fabOKlZCXyANbyd+uNVPVh/Oha/BmdWBg5RZ1dZsEwjK/X/WBGUY4R3aFAOtBm7Zfbm34ZeuqVqvQ4xMbEYrl8amPPgaIpCq083QmznbBiiNd3Haybb+RDhcDFBeK867Y6ucxuNEx0yLAuoN9ig8aSUwfZB81oMD5JHAeNDovRykpLN9T1fG4u44bkZhziW+zDywC1oHf9lKdiVjQXfWk18SRiOigfbdGYCdnEcZmbUgKr3FAlxZTy+Ods5ZywMNsUC1n6qyKxLVqhvCFiVNwWXh1VC2250khg4DXNSu8qoxK3RxE7DFz3vgq+6l22Hh4uoZi5SeHrFu9g8G+YF/ji6CHqeGTpKUxh3Dqa4exay3YgyQZ4JgZYoqDB1/H8HwbChLsTlFDt1bBKk1+98dZAqojlDsOQ4RgSlDoA6o/2Uhh1pg34vnP8uwcVrVdlnpPnnwjv0SPIjT9mNpeWyRzZaFLsd8eIz1ewrPy+v4OkBCS1MxNfbTBD0JsKfBgvGkEwUvWFZMlj93Ko2OkjDF5wny5+G4cFBhhRb92jJD/63maPChZwXrBTTuKdqFxTHPrvEFllQEY0SK9EBs9xxVSjenMxSL7Bu9SCZRyp8Ja2qDrdYWCy6F29zU5Y6S554HFOBP2RXzf7sQ85RrAZhJsaa3Wrm17m/Bu4Fg85ywk3tb8TfYg+aS6ngj1n6pXZLaQcG8lRrlG9FGqBSJ2DUcRit5g9o9R0mimt1M0CHaJtsEv3h/wg6npuaya2XI2MazyCzFrOTF6bSqMm7qU3zTiM8bKRgqZdwkEg4QtkInQDun9R2uLZJtK/BZ5U/5s0Bvw3DJdjsKCHdF14rnz7nb1qn9YEqIQKm4ixx+2As4BMcLBQOf+sWgXgq5Oes64bMh+V4SZZDO2+YQHkF86zrvBOeHoyhJzllLM8QDZ/6gXvGYNlGPMkc3koJjAHE1PbapWx50gfeNzX+JNBhRVRGXIr7memDDF8r7Rz7G9LU6FuAeBvMEIcbevrAUIfqedMJTTAwoDs4xSYB/7pnp+aE7zBJOoYYIRTJUoFl+8KpTHIFGK9iPei4JdVkuOrqkg6WXjzKlI8t4NjBuPmgPT/xOy21UT4BiNFUp8OY/2Pg7/vUkpiZNTrKKdepuzrn7OXGEHAFZlYB01QtZF2yw9al+aSBKsTmht+oz67Gc2oRbkLB9s6C3ZhSrVmQzI7P8HR28LedMa81peQmGSaW0Uh+kwSvj988RBwGUEgKt3zlLBMB8k98OuoYuywp2GnmIzKqIRcj+/aReei1/kE/ekjZZnDD8Ua25Wawq1akrTFy1pmuFO0fM09Iav4aHpZ+opqEmIyKYAuaqkzouhMOtCeTwNfAWllYLDnqFR5CmWQUVwjdl1kX/GcMrIrZmmEKhueXFvx5jWVEh6CqHcmVkZ0LF+pl6y40HMOSn5Mf0/OStLsdEH7ecfa551HBeXvn0bMRI4YX1UQsTSBgm5gWAkFJBIOmAev0NkXBPjiqbTga4qzL6JqZ6sCcaCc0YkEqWh0VZ4RUhP5VNI7/kjHcQMLC0RhXPFBtunkCgDUpxBRFI87+ClZI65bkeJMu9J13BOsORX/xoiZ2+pXjKbOFy5czA8e42LKSHMA6zzeFr23sHgqRGSkxrKUPmk6826ui/TSNqtK7xDrVmNBOasbwY+m4+y3BbiBUOBKL4WscHceKTgboF4A5xJaC/GC0qekQcRNOGcZXgGeGJRr3awp+nzJcO8zoOK4KeGyMsTXmcFofwB7XaeKNzF7/kJVmKhExmdbjd3CLyA5DW65BZrPeJDUGcw4v/Z7khnOawQzI2LNIt4sP5z6cXV44zw5xj19LHfY13ljTN1NE1HQLCCcOqmgxnnTKAaUVHEzg35z04Ki3M+B7hrCwNdwHEfeWF/Ubfo0Z14o3QcF6mbuOIMGID8JB6hucMbh0LIGvl7FA1EsmBdw69DvSv9SA0dGQUJdgLuUsbdR0JgDfgyCABkk3Gmefm8mWGqk3IP9YBPZwRUrrHbQl6lhSqsHQ5QVy5pMjywupAMe25ENQ+VrTA1jaA4Av0nxTFj30aetKbtgCGvLeuZZgggp6KXRa0Ku73qk/8LESIkfrl4Ev8EAz9voD1CYteWZXF2V82H7OuRb8r7h0RT90skYRgFk9a21obOCHmvUjxp0qS3KbF8cq4WVLdruhyHp3WjBfYswQ16K6qMBF/cmvkvWi+pRH7IPgZbWniC3FL+NU/dINATd8xDQaw34+/ju9JP+d7X5c39x1/kg0RKDIoRjyPuF8tzovNOhfGl5b/cLWVEZTWqovEX6m7wPchxxONaAGODvciWHNMg4z+G5NrVXMZHkCsvt6vuPhNdIJK3gGME+e0lVJLYGKUF0vEtVWT1kqulPwAIw8tI4brkpYEj1PS5bOMRh21KFsf97lrXZu0F7YivzRgvJEdZgLmC0YZ1TuZYKzLBER1uVDXbNIFlj6ESx+SZ+L6xh5LFiIxdiz4YsQPD7JWYstCdDDfTgacvKhlPrdQ1uWL2uZoLB0+2U+pOUh2sKMmbTJDzwsbRuK4G5QPZf3YR8nalCPqtyOmwQQm0IpvAb/tEGFGmEvyaQ0PmZxfJsu8gcetR6ig4saSbJ5boMKUC4LxrTkUxiotFR7A3kMLLrWXVOcx7ZYzjnbTerdM1XqYio0qWzssa54Fs7o0v8BQzSqqM5VEYJBXb8f4TSB00y/cx+2CWiUHqsoAmH7xnJRGutR0hThtySn/lF1tncDE/HPWGRdpSV30ryW4Qvhqy7bYSjtDZQI9YffcHTeMzH/wJiUwd5PxCTpTPyj69fhMGyjDwIq7cioh8lyW2WB6y2m/B4CxpfXe/asuk4VyuaDowhfT1CuURHMLmyiTiKYf1RWmX7EZDQgr/Q9Y2osiA005tqmCMFrJVNoWmrA7qxMKdjUYe9KaTUa0etKChB+KM/96+4qb6IxNPEza7hkF4woToNiBlALdgMBTVcvV/h7dmnuwcwnlUA+GbzxuIy/qtBA4Fe5H8oE8FwKfDYha0XtxBwmvS/DPrSNZqX1AOAD0La0alY4sycNOmjAn5lem5+YkuJYP0dqWQC00BC0Z3hJkfC8ZYxsgLix2DV86zymkGstPRYsuFT/ZroXpp/wwjUUbg26RiM/b7j9da4PiT+KXGZc1BUSBBMUmDEtAa0JwfjAxaRkhdUtYQEoZ04QpVy4ReDouiZmgCGHcTBZe5UHsMhIZ3SLXYtvEIBr/yATBOtBhp0kgEuvey+JdDi3LhAYIW4j9k9m446HJoC8w7cJU9j51Gdq4Ip3UMizj/oKysVQjUdWMNJGFbW9KyRAKRa5ngs5ILxeCpe5eNujbI+RKKKKWq58QKyDTweVCbloneKtsUKBTQcd82WwGHi3yQqbJpiQVQLae4OwcAa3z6YxniLv3YCK4NmQ2Rxd62IkcZh+58tZTS+nx+x9w7XPJCGmodom6cTe4xGOSbrfvRJYpLoRr52w0FF8spsodWOpEOuiqnOU3DgXSZzIFXte3s5hRONoxiszCJUbICf3NbD7Rh1Ticpg5Ahlgr6i5j9tqufSes8zjDCgFdhrQTLQOahajTA6E4H09QlyPBRJGCfp/Ty/cXf0uZhs00HXiaH8KVOEJv5Re1BLraKQ2wukzcp/IADisW0E/IFe8eHRq8zaU9odkk54ZJdA4pc7OUeSVO4AMFnr67BOTVxzvHNJ+G7g0AxccLDIKRNynWISrI3FTqbCMEAIMvCqt1jr6YD9fBuWfhKvQq9w4FpvOHCY6zV+KKVZWfpVe1v+qKVtjWBSRx1eelbWEVq4gHDSar1GXcJ2OLqieVQtBwC6jpwwfbiwRjyr9NbggPeP95vdZpLWjlWU0QMO98BHakpwOwkn0pUmIPfAebkw5DzvOBnYUNSpBtrvDO/y1aEDLxV2vMwPXptuqBa+8Go6CSRZSWd2dItcy1dTRkA1lqMJ6qzgSWESgwJV1sWt4PYHA2lPs5etdz9omEMSk9Gav/fO5kYN+axWrivllma/rmLn9MT36BfuyK+BW6Us1ukcNbrLL6M5wAk20bgmryx0fsU/9sePrXFLtgB4D8pgCpLw5v/hWeb8scoAfEp1LyK8HLB91NRvib8MHkBcIHIgSg4PRVw51dklx+VURPqsegaOW8e8KinuJycAMVYffGdgTZh7GaHvFHXYx6whdraD10kKq6W5w2fLBrFSCSacaTUEczDuiV0A8IHmXvHZv9XlBGTq/BuHj+AeoxwwqP/EyzGFy2e/oI8xLD0N8fC2rjUOk6jq8Mk/BPPpq4ejEo37I72qu6PIR7zQFoMg6MunSGHOOYRkjLt4s1fhpZXTXMNC3AhHlUXEVrDOUaaTl7r5d2qLVQn+4b07yiQHNleGLg08Y16+w2JvANbCi8QrLhNaZIgeCLqpXJc2xaEVK+ZiuFPruluZ3bP2kz0KuwayRUCcpjzXZ6wYuMCk7l7xcvPkCVXdGQBjsm8yrM97Ej/mho54K38oTg/Vq5j4KcQWoHRcE/Y/yZTrgve5T2pesVxekkpckvnhp9Es25TyBNzguD4WInMl6HngcgR4G515jMetnwnec3VQRepTNcGik4EGI9j2xy+h48pt+TI/Ufe8wjRAqcKi8yQ7Nujs6TyLM6JdXKQHbyu4m6SXFQBqEZZPiM6srIWsLQt7CIGXWmGFG/mP+FXcoyhhnUGjQKW6DVYKqbfulCWmx4BpY25oesU7YJHs4yOya7jyb9wExyqhDlWyD8AzsOc5vH1tCyifJo3+jIoFAeMSYXAN4N6WR7bPRfI8rWETo/LgsU5bZNWyoM70g6KggJLYBn/S4AYFlacpgt4QLX8fBeXe9dRYtlNSQKBfcrA1DP8GGbHTZHOJod0XBgGSz0sZM/jKj4cq3j+OT5c+G80Vm7syBigb/VJ4Yg5sR8BiputQm1Yh7T1C0CKYyokDOPPgUr4SfNAPDY8I5aM94H2CFeZHRbhwymYryfeDzphUHd3UIhrL+w+/her+/VAOO4NM+G2aURJOlEFdS+SbsOv/dGTvlZVM4VM25OjyUjIjfo91cwymOiMBc0Rsdct+Lt6m1lpjz6p9MHhUc4LkM6lXcOnOpYGz3VY60iK56nIs8KmWX7LM+COq0F1ijGRtCGCwPgsvhkAHJlttdvWGmsi05fHP2D4Pff5eLz+/7YJpsAvTVmQkXsZDfKAV+XWau9UqTjflKo2cFLFQz3scbBJrdcjbKWpd1bOZlV8xRAL2BaFXY6BBqkvRx1yBsmKQYQc+83UgOJyM6r0mED2qUQC7AoipAXhsCJUX/bpczBbmtvij7oQLgVVknY+3XF8G5ntlyW7muuAqpYV1dHtESq8ib0eixeh40Zxy6kpwocz+WIKe79hfUP2d0SZdkTDPvBYHSRvmhVK1bxjDscCAFIjhIBOD06U8U8HkmrJf//ys0fRhTryufkzxKsRvQicTns8Rnm5bbL/vtOnutIiNK164cFHeAd5C++Ilb34FinFQM++XY29Hjp4VBXNisZUa0cdS962nf1Qy3DBdDsMkOabk8uERUi6nnCqqf7HrA8psJDNx64akVEpoB5cmlUty+BmqP+JMm3hNhdC/n2BjsoDklWyTpevNIIUG9gv3RNn/7cs/jDmOcF3fMAaMUlmUNQUDUy0uzo4wwhheTC46J4gKcDjWErjm4Nodp+J36t/1b/b0//TEr1OoxxOeRdUs/YLCfimrTx6Mb04JMItHKlFAtk+fEzEO8wOEY+2MJcD+S1/io1wze43nyJQVJfL4jaAAM9aQiaEkm1Jt85Zq4sSe4vdYKYTRl2dpDMVbEaM+srAWgS861xgZPDnXMYQjbHZD1qq0fPkq400Sb8CmunLRr5dojsM7jTZH9xLxIAjE4ipaMAUZmralE+AWVye0mPDqoB5FPOmtTlsGtwz4bSXa4arziNIO/32CvUbq7t3Gaqy2jbhGh0wGqxdMpeFosREnXzCyiidHUE6Ug5HFqQ/mWaPq3MC+UfgTRM4PrCS3h3BpEXE52vRu4y/321ggvY8pqMMgImWFSCXKBLgYbu1IhZ1YKZ35SVUyZMZm0vZEba+FUVrG59wpLsdXukLWeRoSAMALq/8HY1bEAvwxVbUztR54cJXOdlRleI3/SNScFrS2C3Dd8qXLcKIqRGH6SOIHyqzoScZqnQ6yrNwSEA7Ra+gn1xOwZXWjd8Qfxr6UDUojzu9UixNM3NZUUC56CRHiHzehUk0idF0dq0/R6lGaDUm4RshDFg0HorRuykTIC5fX/QVqZbYfEb/SOwoL4WAx/t5gHOc8WukqWl55N93wZYWakqjsUzM+yc8fxDhdMfHjOedUAJjKIKQ6ohVZ34Io/QoidhshYV6IVWEEBznnaBQ11s20sh6OwqzGf5z0uTyd69Ce+9hliFBzCC3bCSoyzQIQUwdkoIU+3iwiFNGbd2GPsGpd0pdv/GpC8a6trv7MgIryPU5RcndfEI3DyagEbPWLflvsyHCrorg6Yi1ito5nLx1S1YaPvP8kXcAZEgv0iOZdIrmD3dtdyhp+BhSv2f4ZyvTyqCKxbzaN1KTEXuZsl0mF7yZXrcspr5ezibSKzmE60M1Y/K8jc0j5mS6SUz0NduD0nGQ+6MaP6aSD7B9NFDdqNms9k9OykPMRohcavUkIzB/G14K0W2ZvaMRuEYbR/ZgVAfDDrwpxuJyDj1dqHGeOL/YHMwOp1oB7swHidlYW1VcArOlRcgVzO0Mgqo9wYBUvjcfFycgzf0x7tEIWw6yLuZ37ltbhf7L5KGn1urxEcXyH0HdM7LslKZ1gcvU5AlVNTtTAR5OZQfRxUkreDRiFYucegO2fMb/RCvRRUSy5n4mnz05QTGmv7g86vB8KP2epdJHdHpmVjTXfe9sl361qYWaO+DQB+TLG+yIycH+ew/Q1WPNr2LD9ThFtyzNp7VuX0dbVq5fq2Rru8pfjT9UcYxJ2Ss3P5f88vg+7Zijna0oE0Zr0RSs+VqIKph4pz1EDhFjSDuPc1emHEaUNusrvOypHrScyYh1dE+dAH/qHtndzk2ITcPgApSVMgnvWJWSQ5Byz+f5nWavXa/Nm/GQram0/KXgPDE026cAarUxB7AqOwgKKz2jHgNhFglmJ1E53oMKi5FXm2vE61uVwwdtPDJOLIuQ7+E6TTeWYZhA+zzkLmPs9lledjXswktdG3KEvHugNCUuNhiG/XRQ3hill0pFYIv0hh06IaPhhQdMfgO3hlaTzKdR0FnkSD3zHASKO9uuN8qx3YwldNfQ4zsotX5L7/eSqLdXpwxqpP4Gw/8brks7YQN4m3J8MAFLecMZPcTflGAX0HYzX70LMWy7XlKIBRKOlYXhZPL+18IUc2Ed+PmXUpULEp6wD1MG+h31zu8z6ApbilD6EuBZS7Rx1OnrdIBa9NNpEqKoBQI4f+NULjfSty40PJmCADOjSZTVDqxIUa61qCf6hBrCM3g/JYKryXEWs0el6sccSdFEchsJZgzf6urz0APvOw2G+NtKgmgFOGWtrRvPF9KEfG58Dr13yc6FJdiw4trGUTcueQ7NI/WOdgq/w+kPp+G6SXMb3XEt7MzpOD6CLuz3MBtiJVnpsGxz9EKVlS1WpOtPSXhaUODGJSQxda6s8fy5y9posrI6/l5/tpRIgIHFSvkQsmBo3y3bsfzNWENOMWdyRNvIY9oJ5W9RJNY1zs0ahQkfZECefa5JO0hRMPIvd411bT4RZMJhB1ehcYbnGbIeLHUj6GeacizzbSWy3GvJjX/1N8rZsqXa369G7HrWXxWQfMUNxVvCwwxdWM1ANWt334Zu2ePoNvjjsmq+jYCIHOYtK2FuHH4KPNjDO076UfNrb/Yf2QrF8GLapGxnTtU4BfdtD3egAoFTS7pec/NXr4cbHOpRj/zc4otMwAsNSjyehtj4mpW5ZTp7kJKMTsL9EyTWtCt9WiNDJNRlGcG/LMucOZWEjsB2WT8kb5A6D4EYp8ygQRjXZOETTwb6zWp5aHVzssNEtER8PHBrd9TBwhFV5YmtAxm4laryU4WXlqhwWZqzasRmOG4CfWAN1H4Pc7PpqCQOJgJMuBi6mkSqIcXTIGcnmOsLKVDI/9A7/JSGkMvFOSkK900Pn5Ao8PYk7oKO+WtIsc7K78O21A3/JyKRt0XUY0Lka4cxcj2vbQTUPs9tGmCnnNeoSywyJByJX0m7NVJ8W/7w4+T4PadIvhLt2jp4nMpRRqDIsbLbMMofNoJZfrWiy7Wc86hFr4C0nDNj5D+PJri18XPo2ixjzvhCDaX/zOu0bNj9yliwkanf2lDxRjvuWfNDvmdAFTG9RIIGxExIXvD7Wprr+/rgvfnqK+CekCaOz/kd2XkrF+nYLnLMrWY9/qKNhmnq9j16GF1UPMGknxP3wDrbL3o39Qsg9bOxxsoReC9Ho3bGhbSYj7X4ojmwM18gP/GJgDIYRt9j6Kr8GWss5srAxBea5XOTPIpRASDQh2akmKj1hP4HxHIVmdHG/qhXRCt+lZOcYNK2N3mOg0qDvzytz0nzqJwYKGQ3x2oquezV8jF7hPqPNYPFacgn8nBau8BeygQKcO1jebWQ6D0IkusPaI9k4+V/4gj1gj4URuM5C6srVqKWhcestFoIUFIeWpU+6Rx2gAHzJuCF+gyg3Bm1xDdJLCY87pgXs5F5r6xvfcAZ6llyFuDR2Cxxb7LJReDU/3GruK1QWw83SsDOHqu49pOVmMDrNCaPXrhngXOp4x5rsllyJbIs/O3f+4uKNeLnvsywYuLx0G6QstcaAWafCT3CsS2sFZviUlNYLz8MqFEpHm0ILy3nYiVsYKww9akNKDtsI0l7QEo+XgQ0g+ccmvCZkPqXxWqxVJNzYsVi557pHgDR6K2UfXMoOGYO+wMg/1o1K8q0+jwg3aVFZZOLOhhmM7w8TWYv8xjsPKjzEeq7IWhXH+WdkyJXOucjSrtfQlEpqWm7NEluzWka1s4X81PCt6KzxX6wYxX0sxsab4MMiI78LrVk/aPAdajDqfT0vCr7tHon63ClC2IlNDKfFu71fVMjisyAB53p6nyPjoeUJTsj/hKEIh7oy+uMUm3pvU3nm1cSNEqYzrdiZxKhmnzyj5ta3+79SYiR6F1i61mGqGOvrSp47DVTPk7+QgteggAvQbbAJnUvksP4XCaoe3WW5w6btzO+HriFLyIMHy7k4z95/j9hegn4XzrdB+h8cfQmYy8VYx2gRkLwoJNOvquh3f1h2G3Zyy5XwQNRdkmf7D4UC4sfd31Jj8CEeJA8BnVWBfXadE+zN5LW6WLm1+N3eRTcKAKgygFrpe/MlDYjVyPg+rD5KjdKb/La1N4GiZen1yo65VfveBm5ezixBZKjdFn9NmvIupreG9nZYNv4soNkgN7P00s/iqEucxggITvvWXSZP/RDoyco0ZSP7dhIUw/aQs60ZBR1abf2n0RNM/6BxDvUQ4+SZTqFy8CWgxuNo2yBTlhSqyX5CQEqPKxdVen7Lhlr+5OucNbW/X5KaOd5fKid9oa+blv0sIRyGbNr14+1qPRZkz7+bXLTKKmUFaxp0hISBMXRuofa+CtuXtEHAuNsy1KUl7yXMNRFCCHIRAQ+lto/jYj/9Pc5thdlKWk55gyGojFBSaoN9kgoRwXNt0NmpoqENLteONtrUhUN9UjjQp3KFtXttzNGFEgP4M/A9pXS+zKMiI4D+6PDNukopjraXU5XcZ8n023K5mSLUM2/fBcHFuQbhKzABKsNqVM2WG+CX+YXrK3zqRFOrXJLcKHc5j4hOjxhLQc8Je8wfobOsqGFRso1APgdUifoTNYSU5Q2GvkUhmUsvrgLrcCo9r1oY/zlcGtJW9ruW/CyOEOKZsWh1Gt9lHhUgDQ6+2n0rhE9hM5wvX5Cbb76tq+1H5qkRiTFbBIx7sbS8HZExNH26Nkp9HEoJyStUHENeTjHS+ZufBf+zdP/ttg9VowzeJYlqxhHv2w72kD026yaFVK/sKcagoOp0bwFDcHOQaqD2SUjtqB0ACW2fHwh5S8wgeX3NTvx5DGIAodDX1Sj9oOoYYf8JCUtwYhbTWsDhDxf8w3gDgzFxQfL2Wtgd/yzflE6pOFkgj4OVmHGOrfK7n5Tc+g7FD0lA98ldTORbTlxRarigNAjpKAdBZ4kiLM1ZGIh3M2Z6G6T4+ReCSHyO5jFckmfBEW0EczO/AIvR5OACTS6Xpo7pKgkKRNiNBal3BtmX2vkY3dC2ga/h/nJgkmRQFaUoFk+bbopqCn66bIdI0YegSNj77d5zgPGsievKtabD4PEm7ebXId0gSHo5FOaVSKOHZAt46o9aPrDrCiCeXLZ0gpivnbtyQ5bNPhI00jrMhFWZB+aJJv2UnHzULe6QNfCcyJ1QRZ5b4XOX/9GxWBLrBK3iJmxDvuWCtjp6xFa8l5Q6t4nAnfvySt44sH4EPZuiBckGrk1YWo/vtBUYKdYZxdH7op4rUSssWYkYEFoMOc1xqfpy5mZRgqFuZvkgV8z/rZmdkEpfnJkeynr/3Hs6bi8slVxRstMsF0IMRQ900p9RwJN4pO0wJEtOO/KjyNmeFPe4tqSroWpzCpUmYPsa3KhkX0MSVaNruhE8NcUFEq9ucOCS/WdUO1TeSIUCncPIDQboutzROSHMLpFVo5jbAvteZftcHd7ZiT+3MKzOcG9KXR+et1ZRxmMjCnC9Q2t5VkKgOsRIX5A8nf5gIGjWMXpErMxcMlDY00+FnNxZAcKsfGwpkfnmiFPXOh0EzWmnYFGd1NegIlst/AarOWfAz7wk/6dR679UUp/jRfE8pXZsHm47A6wmIe8MtR3TZq+0Hd9G/JqWPtqJx6GGNYIHZrSKhSyMjvauTLPGT07NvsKHz7EFe7TE6O6rgeNPJd5aSXCdwormQkTtadmEv9Ue9hxrP0QDYgS3jsqU5Tz8XZO1Xoi26Uc+APjhCqSTfOBdQ9Y6RB7dVNx+AT+bRDdCan/wfHcbJsB3ZbMOQQOiBQAaoJfgESTscQFI0/jnhMsKkjW0RSj/AT2EVwTkP3JOfFR6GzHcm63hjvqOd1r8aFe4sxati3aYGYQLLSTBcFMSQhUI+LXVx6hzXkQ8D84WGTBiob90eXr6yDdrdeqLl5zpGCrShuqPGpFcCXqL1NylNK60SjayPWm6OqdoYHHzROCzkwaLtC/glyFrLtVYYLBBgO/6vGwcdbNoMlkWkyDQQFBRv4H3vGF/AEwukSS7W1k12VC3GhSuxzo4QbgVstDa5dgeIyorFVAJoTPaCLibIZ7LqkOL0bAkBxmqYulzOcm8e1+TtChWJNPgZfQjJsN9sj5guw8K8e+wF3oqLfU/MlTI2/nahqdYL4ItKXGZUh6xMiLJ05jkIaowsirVnb/123pDkd81qeTjA+BgdIipLz6tOimco0gyLlbpxXqanthfWtidq/djH95FvgqiCitva0rqdCDt5aG1duIr5YcbwOyIw5QeW5PUvcTctn4VcIyh+kH4OXppVmOouSriK2ZR4Kpn42Q//8+B5Mb4wDtMlGQ8a9uzceCveUAwoAi2V/fWQwvI4eD/NaOwCQr3MHOadV3oRH3WcVwPw5RrKUAxQ4zxVvfug/hSB1SlxWp5RPa/kNKA5T+dNorfMHQirLBPx+jwR+pATm3mcozwhZzZ8m1+d/xWJXHfJePoEmJnpmnHRsad0vcfkxLbxzCoQCC+8O7ePG4bwDFA+3GTiQ/yTDiLSgm6u16+4xEsDdnT8cA2CUcDL8ONyUv/nCcLEVq/xP1Pydqn0AxZTyFPrskz1BNtwrx4cr7ka1N7Ctiziz9PmQgaSIPGY3gsZlUTv2UqzQkMQO+k044suzxv5U0K/zQYVFW7kaFnxfoiHFnsRml3/IIBBwhrd8tzCQM9WvsQl4gWQ48NSzhjfyrb0ewTOJFr7TAYO40J1Rw+Hzm9Pv3UeKzodf9D+EtPIIjdIkYKuY9dNW3j40tPsjO2Wjgy+gQhI6Mwc6bvQoznRvZbKmByQ+9p6b9/SM4OWaPDJyt5gWEBRSfOwiP3FtH3wiSc3FpB3u8ZxWpkRH83vRo3hghBCmnmN5b2fBxPQ1efvuGa0E0SVs/UhCmNWArCwXWpKlSuaq/MM+IdOeb+NaFWsch31Ls33FQpP2coPotmYta5GYmEdgbvTwy7qMm14PEYG9QsQGVmM3PKSordsRRvSEXhvptZ2mqh94OphGejVXhA1VeRFZbZiumkE5+bTAY+wvufrk2AsLVOa+3/k4JvTL0kt8YwgJnTQWR5BXh8n0hjJgwmfLbbsHJNfuUPbcTpBWO5qT/M566bQEQVg30Bgnt6ZI5wjCg5owv2Zljp++hIsOGgNa5lRLrJTx8MsJrHrLvy61JIZgOcjWVnJwaiZuDuVDwtLFy3lU2qM/lK77ErYGutDtMG7ZFQvPvFkXmIE1NZkN8nAG9Ctx3gjudZaRIvFR/EPVhBhqXrm/MAUQcqzmL8UwZjsV29VSBPk8NoCColXgBn9LMXbCnmA//Lq0y0OvU2pXXxe3sTsdYvveApSM5p4T3bmxXIfYVtjWEKKDKXzHmETfnz8HN2K65nkm5y/Rz37IQa4RObAR8CidyULZh2xzy8tRQeNCAIYPBQTHlo73de4qRoFPbxrqUsfYgiqMtwSro21YCM4o/QL2ZBqJDw8PryHBCEZea4AWW+Hwu+qibHiDWh60+ghw5bl3cY3us9+jraTij94xByiPebpSIZMfchm9ROOXAYewMEfSpuEwrCczMUFXGCBUm8rhvLehzn9wwjS2mIg/LLRdjhThYsYHJlYWafni2ZwpehwHbkXbfUlznlBxbH7l+QUrDY0wwg/qZFg6f3cec+43y5egEZI20in3ciFXnGMzU5ifpKrPK0HK1Xm+Nujk/qfiAzmKUf0dx90jj1lONfzAFtFAQrNEAZ97gDKG4eH4zCrHbkPO77kcisGWAwcQTUvTeedW59IAMUpN3G3WoQaYPgkM4M6gHWjmj9QrNbMfrkXVs/2ZH8DtWg79UsHUF5T/SyIn2TJEvcoWVG32Vwww5lNPYlimVDcPkES/724HhRgLzv97sD6CgEoDMgs99Sd+Ee3ectnP77Bcxysd4CZpHxLIyfwnNibSAlKG1AEfg/gZjRk7VVbuQUm1Sf4r+Xn24xVJzAwMBwtj9axkUUu6+qvdYsYZphon8OaQ/ja+9K4t13nR6Eb26vYP26F5JMyM7KWJ/2Z4zle++5fHQwGBGfA4yAixle7yQD1FMSaYJH07rD/RJCFIssamS/HbzVkhgNy2ayvhj3KECopz5umHtbTRFz0G91v2/xHd5aiqun7u8HY+7aSXXZhRFDhQn6W4FidHrZF9beYTSdC5Zu7hTI3yW7cMQI3Fyc1EGjodNVVxONzShBwqv/gz+259fSm0Apkg09aXa3ZWDd2TvuPCYqk09uyho+Mr78vJ3w4/k6f29asMexrZUnyXTqQ96557WxJpnwO/2uB+OpflqYEK4G6HswonEwivOtVUn5XyBU+XiT+vMSapKTNVpYg9JpxTkUg3N2v4672HO6MxquoC+fe9/YwNfHIxPIAH4OJ8vWMQCRgombyaEqw6o4HvUb4Jkx8XAx/nOAOXOd/Ce+LS+eQIrFGmEPDmELOT+x2m5M2VOgZ4J8r5/Tb8lRngnmRqY4uoPObcXJHfQya8Y0xYl10N3N9d8VS+ZfQtGwudMsi4Sl3HgV9C8BG6CWzwhSC7kJF35QQN05oi+E0MyMFhx/Kx0MMGA8iPxHsvmKJUIdIRFyWzJCw7rtctZiQN/gNchRqoAP5R14SWIeeUwI0nG+adxVIFPU+HpSgEkClFEfFFzWIjJtM46RW5Swxl0v09OsLMZga2yDuRDIKvs0vISwvO/8HyfgT5SRLjl/Kts54JqTKoaZeaEf0/dNmF+TOKeVTeyjbqT794TqSXqATJIivzSPmkhwWVufZrYJBeJQjKRS8duhefCisVCgF+5CFJfwIizu0KduqHkdCOKrpXhSsvW8TyZIcw1w6h6fvEKuEde8AoMFUBWDfQeuw7VxWahNGVLMJxGtTD98G2JnC2G5pRh6ALTaOXlfFnI1+UocKrAa2Agyzo5jOxIz2b4VsHZMcEj2e0rSlAUY2kEqXJ0RRuOXb61Tm5BwbhmOJ6KpXWIZdMoZed1lOIoL7dCb2Cw+S+FEgL5/K7QiCNOur6zmRAJOmK+9fisGhpMK2t/y8T2ggDXKnfIsW7ne8k0b4J84IMpb9zm5yknOdmjAwtYfyJL7PopJbxd3bQlbBbhv62xmJCSpGhOnTQd87iVhQwhop1Gu8GQK9+Bq0+7g13CO4h1HTpRH/94/Stey7Aj4E8Oxo+gRVy7t6NQUFGPpbaZZktSeBH2gsicB36WmwN9r1jEGQEjsNi+p/KTIK4cegAXibJIfcOK3i9HMML4OxDFLLl+/4BTIBrWKFpJUsjUWYNi9fbID3UaVlY6s2Pj+2oJkO8xM9YO3iZl/qU01AfC9xmqER7qXK7qFE07R+0VqI6lSgpcH3X6sNdaJnyC9iKLMbT0cGJ6VD6yvK8OBF/fQudw3nhOCv8hBsKiK3h0x+gCtm2yKk+8Sf6a48zEGLKdiRbt1S3S2n80J3MMFXZGslLKph+YnoB4/AYmUrkUDn2bEm2WBzs+YjdQk63R9RvuCrPbDlmqw/JxE7yPBkBpjkW6yBr+n86+dkrFqBDhyfVEiBPkm52OPSciD67yg2/5/Oz7FneBlXFal7DhmbfLulCl5UJX9dJY0sRuGfi6K4ViXc4KS5lI8Omq1JAz5t3isJIDwpnVe1G+IQJ362puMtuXNTfSb2PDkqKP+xIvS2GpONcRkJdZMW+HpjfSCBnTQRQgnKmgayJZqqQuTdONF8ICYUbyw482D4c7Z/X9crNLY7ZXLE8/ZRvU0IHpoFqu1xFHYbxxMfCGYv8sxvfpUEWahTBGhDncPCrUmVCCHLngXguKjwUMY9Zmz3iP+cDu8+7xwFwBGMpT3qWWIgZKQKYI57WK93WQuYQagTBnlGWdcSvvIxWEVgBDjWrUxy2ZWpq4mMKJPvo2zlQ8wS3e0XBdNr9Qw9kQKNBtuDcZb/vKQYOW5sGiJY1KID5F6qFiR9p9wqjpk28gpy6mKc+OWCWmzSLDjvpmCbQ4iXIcwaAFX/fKYetvn+91TV/WlxHLD73zwF5pycwIMG3bMzOvS8puLENbaKPfMO9ferws4mUK2tnFhVsprXJ3tHXuB0BjgDLP6I2lgfJfoQB1P//c0TEYFQ6xDXbaV8D99q5SB7AGOjEve2nyYxxsg6mtQ5NsyG0dOYK/j5pfD8lZzYphShlw0yp0Bj/L1lkbJtEL1Fq5X7PfzZzODjF3DOtNguUQm9FYCy271J5Z5riOteH1XnJ5lOvISseALKAsUlCODDbbEdIDAVdCS9liNMqdxP96HPixJ6hx0I9Vbc4RwPg9ThZfro0HbcIYO+eRlzcdXF3qzYoQnusndGqTg28mh6xKams1+DNg6+E0YyqOOgiN7gjjiVTT4xPBqoyCfocGavfNlSp6hefj7xTo9RtjKuBLgtPiy0uR2674GKY+v9F21NrLSoe+e0WtLnPJTqQf5fiOiEuc4Lqd/FwUAI86ZNbZc3TQ7ZV60zGcMbsKGGPLA0w35HT9tum7VyrU7Muhx6arsRU1mBEAZyPtY9CuQZysWks/8xSPT6hFWZmaqzNjWgbGvnL8zQtA6QOWDB4Y70sqQnNPVYXtfaPMaQCys/jyJFTmOi8qhFSGnnwUBaPnOE/57C44z5v/sbZTbxno8spPTRua0A9Fg7KqAoDLtevJlZpw0MJ+AzC830dD2kj3e6KreBLz4QOeF8NRz2WWUQ3NhdRditU7/qHZqjcT0mY9KQeiNYLxepp5sCg9cvGE3eNAMBVxew8a4gVSJdU283kCADeSuM589Vuhh1pwNAxO2SNw/mTzTptCa7JPBeItVvGK4hFiu7OKwCADb4iJoNDnN0TRVJd0F1/deNpBns62aGqJvL/qsPLbXdPQY6snySwQpHLeMp0G1Okqleaz5x3KjdE3KHrWyvO9hveVJwoYeakKI6GBqY2OQCjCQ/Ea9LXOkvk/gAIPnFqvsrIUoanOsPo5qu8cRRmHC13P46eI+m7uzQG1/Bq0PIH5Vuj5SDG79ZyQMHVuH845X3DEUmpiSBJ5ieEU9D9fAxlH8R/EITdZOYOPCtLsqTZE/G7xWqK61WupZRpv+oVGFTyz7vga5bCRFJHwJA1/lhXbD9f3DKbGqkhowkZB0Q2dQgRDpD1jLOvmZUGUBQtaG35rcNARqycfoYRUXNiPX+zgAtpY6gnPfWlOBkM45nzpEdUnsJ5MmaAsW9nQVpz7DfYI5ADNfzuhhBY4dZIb8BCrN/v9OQJ2qVtFt2gjpnpUqQNk6dNnZWOnCBZZar2+Y1nanj8gzZf+flGFmVyzqo5tGyO0LkzNLEgTcO+/fVND+2lC4PpbPiGMZGxuPfx5ArySC63DEcbp+7pa3RJokIpgAC/HI7vk3uozpFsNyQ3cl+EaGHRuw4L8lq502vaB4BMze2POEkLJA/FimpYi7mCsDXsXQXig2EO18b9h4QzKumqhUO86gGcWJCIIS3PGz+exSPHwyiXp+AJ3hj87/eMaAWF54awuXHkfxA+h7y5OyyWSe8F1TMnUM5L4cxmNPxjOWcc2uh6TJYXEguTPz3p8x4pMXW1TVlAIV41OiLvLTYhxNMMcD61cBC85DVq+a2/3iQXBOwRrdL0wrhQ7sC0tkLeAUju991SUoOdZiEZPXpIrfxePzd+xiIYeTWLtCmK1umaUlYw8gzUzf+7a2p/FfmgaPe7RoLGmVZL8dTn6BvqidvevXHXdlJw+rLnt86Qgt8CCO1hxG+b4GCNncvjibQheFUsex6i8XOiSutqZqkRqdNmERB44sNAgjzUYrK1Nke6qJHJxmMBfY96GNzSBQ1Dx2SUmG7T+BSaOMbgrfYzRMenHnDNg5QsSjrOKzVc6jcJnzrlsKtpu/57GKZlXAVSLTIuAv0S1+kOZ1T3VoEZImlLwhRXzT5yHHeWNVtwDeLhqwdWxxWbjiwFP3ZUfeo9CzZo5G1IpGpOEifey3JlykgUoFToi0zAYZA0ArdTilr0+W0XsZElTjf/Bfe/EwIHI0SQloU/Vtsm134Ejx4IHLZmUacnNUKnfPSEVQiqVncK/FO6fp3SIUgYHvpMHcOODCqrbzdcp4vk/5Mu6PsIHhuG3miQY47lRrY1ybE/XgRn6EbCvLXTEyUFRStm3L/ysMpvHSg+EM0v4UA+e/5FxhdWZoI+TVxXLkWoFVbPgoC2jt2eF+QEB5U2tuUgckSkOZrZKH8tx2Whkt5ZkE97nQOWvKPrcI5J8bqvdNhS6C6aZuY1iGlhqak0WKmxNf6Ai5BneBOHb7jLlKWmrEidXRUL6R2AvKrbcIgGuezmpK6q3tv1ZuXFjN4/HCGNy1vfieIbmWrW+S3EAaF06zp1KNPs/DQeuT2OllGfkz6th7D+PqmLC6d1DCsW6BFCEqwgEaNAdVDwueOX1ATrw4Grvzobw6NYFtNaFgFBCAnSqIFvm6khd1vo0A3VZ9lGWyyfNW25zIidVw4rSl3wU859n8fPM0fz2JDZrGIis1oifrpI4W4nOFgDaUTG52BZs7S66ijaGbr2wYfDrAZT05Es/t43dXElsH/omQrjIwR6TPHfZEsrWR6uEfW6Sje7HooEcjVmc46BASYKxDOzQLls3qIZz6AGbhtDb4Urmt17wXA9dBXtZn9MMpbu0BGlXqPJ5Ppe92Ga53lZI6+cPZsmPb9u9Yems6Yg2/IFECa7rIcuSh7vQcDyrpZu2Oq3fY+xFOy5jlCvjEvn73aJ7rc2ThRFg6IRumOVqtq7JRbj5RyA8AoLjiooREuv7WixbVuSQE3nBRCXV23H+11bLYIK6LptMuemueyuB8wRNK2lVwy4gduB85GcC3prAPh0eMNFFOdTs6pAZGRRDlYqhBnnagNi0Ee38tL9tZKb47eA8bc4P/Sgmq1xpmMMxoLGbI8WAfo7tpWrbGX2dwcRt21kf7ie0Y74Dg9HuXWtw5y4m1OB9iWh/sCRTsJCc9rFo/BQs3U5ro9rrtnj7WXnEoFzitk0zdOoQnWEelBzcn3IE8Ce9YWBiI4qe1bvCaslxEsQzgDCaKVyM5PKjF60HNg7ZMH5V0L75RCmPlQNliZO5qAfu4wmAih+/3/TI9xWZ/MScecX35mTgCevZzuvzhr5MQ49X7huGM36GUp6dkITW/i7Usgq0PX4qC1OBf9ChHnaYR3PNZHW8cy+PMYZaILAxvXLXFZAtNTeApCSffQ3SDOQB+Ze+cyRMZW4t8S04f8tUr6RU6i0hBLBnBj6nr61XCBWmZ92M3I0i4JWmWcuwxrW4RtEphcPkN6FqZ1mAI+h7THL2Jz58b+vt/+mg04Q964n6Vw+9hY1wwWnWi5DyOQRggoD+g9GLxEUlUmM278ToYAlIoKyxMtj71yDH5ZkTJKN2qYU0i2Ysb/4znxTHjla3x6ROjuVOaVP5BtwP2jU6GsDx6msEGuJmnrwqnUsXFQDbh0tl6CuMK0mv/tXsffz7HFqzL36Rdha93c8hnWlz61rOMHwY2+cmNo8t3PRZqLx+SXSp/bez0cwJOZly02ZtEof9t1dBH2qNyUE0ydsZTzZrQiZ+kjGdE+yoqxgm6g3xHTuZBSOt6CsJpFT5V8C4EHl18n2sbg0dKj1dfBPOK7+kq9pXMR821tYWdYicdnQpvnRvot75VkIzNLX7ST1o1Ga7dABt7ohpNUclB8wTgxsLr1lNTAt6eL6modpSHs/WZcm2qsvt7hSpE64IWCHcQwzK0adOI2SFvJZp4I07BrV7vcuzwp2c9N78fTVGdGXJzvCOgRcZauMXv5p9o3OQsGFjAemS9FY/TWBAeDHZDFrvQcFni4PNgsYs0RyEl6aWU89DWSyNqhCHuQSgq9mgS/J14lRQQDI0Yq7YNjnu/K1PfMpz4c8kO5DfiXLWpnq6rpODbLHpGc9KQXWrvfQ5FL/NHJWKtlEWgo15Q/2I2DabHUGrv+guuA0gQKfC+RPYgxlxVvkVkcOUmsnOLpiNfJPf7rVqbXMup+/Uk+nIB6bDPd42kwCxYiECHdpESiDjpGB11sXMKroCEl2jrw/6wTNrD2cIPnsjw3zzb4NZr9ObhERQp6z4fOwWY49bPMHpsgJBOe1uE1OHGz5Mz5N41EJezIyU/Nl19+NAMGJM/HL8PKBEzdX4h045HeuTZiu6OKqeQia3Dp6LXuU2fmuuki2lr5vmC9w9BgT4c9Gg2DyoBITkxqPCjVGNHlkbfl2LYMD6pEuq+RGEFJvw6zfmMxpAS8w533IAkaBY7osDNLwH+B1vd1aLrNyuxvWEin+GG0y7+uBkoUaHaTxisbHM/Rshqiv98b2laVyJqVDD0XI/MZQGsrf8QPXDJq+bbSVPlPmjkvZiBYs/jmyjW8lWChhR1PdOnfrZjK+5TrzMDlQ0C5oq9fPJu3EBOIFs3RsrEZCCBpfKZFrikZpSxn6XK6rp/Cno0zmvZJqZSIznuxIK4jYhy/oQbrswOnp9RV41AkyXZZSPyQXRs0lou+7joepCWcj8Ebos9A3iombrrEUVbx29uUHO0iMavguQA7knD4bHGF4wmtRkI+K6CumPnd5Luwz2nx4F16Vc0GqsSDlnT5ducCXbJV+28WcAmmrp7eIHbsyoG6oheJEkzw7c3frQrg0K7FMdCIEFSmWKYFJbd0y8EQ32mwaXufGbVbq6dbz2fx5TYPPLB3KcZvnkCgAUICCotI2a3ilCZB09fAKoDCBjG5Cb+MXQwEBnVkLMLkXz075EktNEf75BL8mvZ7VXzJqXwmPDYhd7pkRq06hxgSUYGCPd3S6jjd+T0oOkgx1Ehe23EtKVQG0HQ8dM8nClFPX7qjg8UQLdMF9gb1ZN+xoUNTqjq1E80cc4bf/BP7LLUyws9SYocJ+tL5IsBEjfrkf2s7S2QLh4sTGqnVU1XXE2dRIJPVQS+6OU0gEDnrXRbWyZzztDJSmbXby+gj+5IcPbQuSgFqzLkWjBTozN+YmRTRl0CIXVWWtnzEECovtxubVQThiIwgGSglKAHGyS+HQl5LC6+MCJqIv7fy4fETE0tpxv/y0iFc3qLmb/dqkEoM8ibHn6HXREJ9Osu2148vywnxaecOqOU0xnXBLWvBYi9/W1dZ1Ax2NwwyB01C5Qzk6f9zRNAriMVH/f+3F0KpAaJtETSfKDZTtjIn9m5mAs8934+CApGamomKCARzXRXy7GPDBVKogd3hE1oBOIWnVg2xbcmVF7mZc3aphg336dO+D9sBbmJdcwnIUVPBLeHkZKO+mrAhMOxausd6D2ZL85NhtdFiUgFZO6GmUvw57Iv/859tW7ty/RIG0F4cFrg4DVfvUjrBRC98pBTkvKuAoOWHcgzPArlZrZ4Nx2hvnyhzvq/Dk6DyYbgZyFCKicgX0/bKhaCy0x1kYnr5/YGs44kKlNq6yi3pNYh+3DUrRzNFYzsyJ72GYvV5MBuybjHaZt8izyyoQ3m6x1T6FJmGVPUojoBbiEt+II9ghp/DJFp+9pQuTqub0oxahP876U+dtpGZH5LkkkWABVNz0KlWmSAcC426mdfyzX37HmynmEnBiq51eag7+bth3t4XnO8ZjGu5MGHjOETed202B5T906XWaKj8+BgNBeCNMDvEju957jk8d0V4XOottQ+R0+84CX3xcV9O95CIIxzMJahIBndo3HpXpSFpgrfAWb5lWA2/IskLZ4J27WmLNN8bhj9M9U2sX7JOxhs0OoDx8P9Bb66AqdjXSqXXdO+A7P2n5Ltkg3ff+NKYmsxpwON7Fr3k4b/DTo0Gl4JKJuuLwcGkmu3sTwot8BGerQzxorJfh7r5uCXxHaGkuewYVLOmYA/gok030K/wZ8SWcx7CeM9C1a9zVuZnSrzJ41+cNQZY5gaxpKO7rwlywEopjNotJ4yf+k42vDCFRC3QZXIaA5PrYb5ppjdjh2IBzSjNZDezOUO0AAf2KsNSkK9w4gZ8tYq1d+KM6S8nhG+4L4qlkkLKZqnuZV9y7tUVHKOA9NsQA6rmN8XdWO4va3xeb+UeX288eHnigHRtdp7y1yTWdp9rExizyeTtnBIGsWvEUtuJycX8BmTOGlSNtkxI8EQqbCDmnZxxIkCM3lLPpQf6m23PU+oqjIPl2oIXoyucbt6kfUv66uc6AaOK+CYyLc/YnSS61anJp+O7a1eR3e4kNHxNEGVksDajiEi9wBUjJ4zvukRFqcg7rgN6IvRD5kDroTXYDCgn3dsQr8NLAoepWLCJtLJdSSh836yO3fBa8qDLI3Bo2hXzwvhqF6OEepW3L1ZJrXIMMB7bDlL+aDkZNFh3NJHr8gMthh7mSIRLvBlZxzPdfU1MlTOy2WRTHY5/XmmhMqoCsXrosGU9+pXYJzJN/FmBffOBaeh1j1UUqNmwabWbw94oMe59xSwW+azO3l0uPLO/4WKAZCmPEoUM61wXWT6ZnGd+m/PvkqYRj7inO69uWahkMMtFyUfhwYzGqBToCG8AAZnHZHjsmacK8uVuJ3N9kUElNsqu2yYZ9YJ04HVvB/pMllZvx/vwLVVSGm/AzdDsaDY1hWscmZP8POz7wwG1gvoyXPgHhWb8IsKB1/7AW03mCTRTUguneeNvANLLUe7o8MdroIGF4kHeKxLYKEsQs1R/JX21eXdxyyaKs9ftyhSMClSwvIDDvR/8bn39ONmIcXSRVx1qyU7XsK0dU1+VHFvVmPGdu3ZiLGimyGuETabEO1MBwLH4uDUxvLPi9tPuB5RtS+hA71zF67liuQr0rnAcuFA+4NTjKNePA65HB4baV9bCmULXB/WzMTF2EnslFEvAHHinu6OUjVErAQ4R7Y/rTcvRiFNGR2txw84B2JZbpY1wKv0rvUsfP/P2FlFyeku2ajdvKHS46eQifUYy3uoqlfJv0Ln2nQb4X62491+4SDSt1WNaT4pAM5U499t0DoRf1QYrMG2fX1B6qaFSaHUE+RU3ylqfiJ8KcNhjxRgNU/7rYahDYr/TE9jhryR3WDyQt8td53wyCVMsLY1hZAj5xFAVgSwSHvE8ebcFaUdjYcryYjm3sKbIwqWHlQn6RW53PFUQLXjg8yGCfjwFHdio9ZZzD+Ft6ib6pepUJk4hS6e5gKa4xMqoA/TLYSJ0Aw/YvQ7wC49VxdhDQgEpEvwcNtrarb7AmkiUAe58F2WfAWueJfqx4QcdfDn3n3owd5UNSXyn7OAthbhvLOLwSL6BCrqnsMnr/G3/OgNLLQlKOEBdqp1OF4PLaSTwuidYB01H4C8LRkcUKvCIXrDfNeLzgv3XEVe82hZbfpQbYNgdxHtk9ELVPu5+JqgzMrHBuNo9WCfn1UYvQ2l3OqUJ1HHiFFEde4wmf54mHylFLtS6En246Vz3v1C5oXuUSRsO5WnK6unBcr+0yH8eqy0NU+zHb8U7XsjK/7Qz3XvU+PbQxRRsyBY5rXvKTweTp1SJfW1RsE9pJZUbDUCnPwEilSo9izdv0c3QGeh+IU8I9aeFi8lV3JWzyoUXk26liJ9NGUVotpBylcmxwThuoae+TkoMDDp/UWk+4Qt7WIRELiVF9xkMp+WgP5Iq46jYn8oEihdAUpRzVOi50BH7nxSW6GjVCLPspL5nvSNGlwH2ywng8wU2J3rScsKCf+wsGBXOOrnFxXkdGcDmTO+77cbMdZ9Q8WYbv6lP4fDt3elC3DkiibwrSR3dWjf/5/wO/kK2Oakg0XojuQM8PKUCrIVBY1q92BysDGnaD6i6VtOFBQbaj/xQWUOyMGKrI7+q8N62pmGcupjn+ZsBskHLiYCjR41dMAkBVen4grKpqBxlI7qdlZdyR2fNtXsdJzYvQX5LMyGxy+JmrYdStqNG9u6oNZcAUgI8CY5yeG3oNP/tms7PqPNQwaXwKJRO76JIbXt2EBg3/leMqdnCeRLJ8yPudQIbI4zG5j+Zzx0iVqGGH2YxRBC0M3K0T5c+QKFuobwpeqShpiyOrsurQHHPjx/ykufggCrMRJqsD1Izg1MzBttDrrOxumuKPA9ktmwB0UDtm2rPfNBG9sD2kDeoGM9nPliHSdrKQpH5/OodjLcnNVaMrnoydpm/cvFhF1RWoBAib9Pie8XqQli9yEDyViEYQewRfcY6jLCPUbzPdCYqUNww/W/Zc8G60cEKN/UWBCRmgHoinY6f/xtcf53XsWoTysl/5FCaLbCe5GYOyZhmGoUVffepRRFN8258Yw/aSkUueYbCGzZDM4En81tdH2dwy11DhKBrdnk7A4RrRRFuJd9kDN1QW7vyhPTbj9KK8jlk60ey/K8wPFWVi0A9N01uvSpctc15GPmoCpMyCvnripmeqUekACpHVsFyKKZZrlTZfHJfNMDpJnXMBTfrPiDmtc5SfH7GlZaGhhYkDGLnVssQocmoBITN8a4IaG5soq6eRhc8IkaLQ/pHAZEzso5ONs4rLSs4ypGBN62c1Bg8cSKGVf2BgER7h9dqMZOhfeCY5vItbCDkyIdC2Ogv4He+SP4IburKsTIaS4u+nU1EO/n3U+xhjKdeBu4SHpd3rWlJ+2Q4AYSf8RFgrlCzVke0MEtSXDJEyul8I2V40UZty6zzrvQFFd8hK2lNaNAcvFgFCdlq/laEYjtHb3pM0L63H8rF3ieNqwNXJoLkkw31Vkg06CUsJ1t3kFW6baaW2qM7mw4eCEPb+p+iPj5iMMnQFQ3eyhf0Iizu00/D2eZjH2vC8wAsx8+UmcL/8+hwHYsbgSItRmC9m2v7nsaD//p7eYBShXwRWiB1zZpB1btNLB5pArDPb9+LLx9Wt/5RLHHr4ubIOo5ZQy3aGHhn5/Rw1RVFR+cHRf6sUrQokEbR+AwP+Cr0YknteVtyqmhRC2BTYDVYm0+TQ9dpLMTZDZAlnGTmNqSzheYgmj9ICcNwjGIojUtgnc8AkLWX+EeW6wG7MVcHFXxHnyhbv8rE2JMcgWx29hDSoOWwqdv8vLRM5e3O7f4eIobhFs795IAJAPaSJrkvDJcmTht34hKVE3O/I8WO1IMoRlrVRibw6ycnH39WwS8bss+kwlW728x038IS7P15FkbpURB+DDS7zqODfGgMcwyTnvfECrW9D0lDJMARqO1cBq1ayLCF6+j8crdzNLC7fBsitM0jCmLrepObYWxPg3SvSwEVAaJfgTpBLFiX6ckbz9doK0xtFo04soWSUijqv+Vaknsv9e06AWNz8ZcGI58i1hAUmMHSo58LJZ4muuXV5WAOOEpwDri78Y6Z4mI4DuaKCWpRyanzvKmQmF0VhQX5WmRw4skD2HUuDqVK0I6i0e9K4qYdpAi1bofLhF0JZn96WPRuZw5LdYbPN+4d9ynIQ7HRDi3bNYvizVuki+ZCFKSpdVxq2gItnA0ATSNAYxZDe8rAS7UT7iui0UhXouj8fRbfQ4J/ypg17AAqXnAxR76tIuDNBg+dHUTtTu/QsUdnWarQtMU9u828ixDq6unLOj4w8ioHhIWdrpcs7GpfoXxPpIEZx7gw69xyS5OCDOhiIt8HPf+FN/xCRYXZlJiGfyACykQHsYKgdV6eNCD5nSw1iWvwXQNynczU+LzjqEbmRkBIxxc4Q1wOqOiEklFJXU9lTxj451AUu0ejvWPEcpHV3TOHqtXPYZm1MznY4f1PV11g4qdrh2M8HEXy/HIVelgGpDdG/7c6aWbNLdivZzWi5khDnkG/RxJ2CCeqHaz5AQGzjST4OM9hKcR/pgWwBuCS14VFzWu7wFCWF9wkqkv548XtqCOLac3sAKQHI3YzssbHeKqR0b2iMDW5uLWXocM0aqYLqMQKchO8kqpzqvmR0jFwercGhSrNcOydHWgGI08yw+T8QI0t3ZYSewFq+yPTiwQNXlaGK1pGhckEzc0zHKv3geWOFjvphIUXDQETSF11EijskSJo74nJrc7lQS7U0DRoeMIw7y+gzVCp1Keh94gw3iQw1VhQ11yuvRmHZOX4wqxzGqdHRYyJP2tN0JrpmpPFlqCMxJyptWL6ziEPZJE+/2KxyUytqeN4/OC8ZDmlD5uednkNH0TN7XWdRjyfn57pRttiP87F34idv3WVqcH1SeGtu9N4x+pSt7DUwMFaGdhCWmBdXBCh8n+zbKc2aGOmuiz6BL3LecWIqE/kQQCFIuuGawgQv10T2PgDBMZAm6QzR2u+gcpMiuEK/gNm1Psq7Fm0dhCHWUSuwHwwrekwP5XN8m1tYPpWq5jqKVbVeD99lOS3rxPC8zAFO5waw3LjaCcOhWhtNLWJhhb6QuSkHpFihNk730HtjtOAbJbxhgzhZ0u0JLyu96S8VM06rNHsAxc2YOEurlSDb0bGbTpbeIHTplzxv1e9aYHfaC5SJ1symxpD3GaTCtI3tZpaSvHvYlG1Hc/uCjfafCpo5tQQ692xuErWMiCz2YO6zHIb3SShQt0Z+BSo36vmUIp/C+GC/is0d2VmloYqKw79smkBMbK9lnWxjwMU24Ywu5reNb7kxPDke9rXUBlEnq+V09yff+FAkS8FV/e5HUwf8rXgPbattpraL0fvJROC54lVZe6BJ30D7D/5tLwF3GJ4T7gJ8PGAAvF/1qV62CEooqshFvpgVLtvCYREo9N+fUvpj3ttyuj4BKmwr0WkCd0OsnHba4igGMreV0EFGkBaNwzb9cynhR/7Onj1ZXQfm8Lv8sTjMPQCZ+nLEBsGH3YSUaBjDqbGUnTAES0g7pGaYLA2JyepgMdg0Da0zBiJzrMf5Hx7woVIsBUD4IVH5Qzt9BgESy6vkzrJfQcoOVTLHrUTZ2z6JRKRdgZBjvFilmECoOOBTVrc09iPPHE71250YIvYvRQ/PiOJ0A1fHgQUJB6Rf0Y4VvTFasaCnAMR7X7mXMHri+caTGJl46G2y8uigH0FO84Al8gdPF7AuqWfiMrBXds7E151Tf3tGqeczdFxTOBegnOB19RuzdY3jYKTy1Th3apRWOnC1rOFOkgl0gw7KK90bxDN38D/ikZX453BNfVYOU6TLU7LdLvTgyLrizYJ+NQPRgBPkMVFvWDPokv1hozjfj4HQhpAzkmfSWLygnMFJJnpwap0chPgt/jx18XH/UAUMYeoDCS9xXdWBNahDC+yJmK0TsvNP011VGZTzcMfIQiwQ+4oG9cvQ39aralumIQrxC0EIuTGe3FJcD3M5jMR6oYc1mrUUpMdyRgO+FmAsluD682B8F5qs22TOtHzVg2rDLpU1L+dKeLNvAIUrMnJftR6SyVa+GsbFU6Y9uLuAsXF9vkn/QF/dI7PFLc/Z6f5lBmJTWkZ6ks6tFKa7aWbz0fYqOoZW5KMR9S78PZtzJnuuIshdPb8unAahQ0XTxuwjKHhimC19APZLOsR6nQy3Y6+DRs93vpJOgHNgh3nMXbCb91Xs5om6aDhkn6uWSC06fNDIbmep2HQUlvgM7e6VllET6tEwqP9wysHvLLKm39ReEwRZs9d7KBg32W/CZ3QyZGpyOPYe1tD93ZWhco3eGYEnnzH8wGWPUa1doITu1xEFWpyknEy0WnFdFfk8kZXW45Qz3kG0jBlg0Yp08HMMbWgh0gCPoZN25v6W56g26o51TdUiJnfH2MG5k6sNkb3C9gBZ5v85rDMmHuHkcdDiG5cIMo2PWDR7hnCYpYqljB/Vw+0ljgA6/2d9ViVrcxb17+GF3++OTVJKpH6JIykPifWXSOmBDLDi78Y9Tm2rH7LAhA/tzVCosM/nEl+KOo0UuHqunXC4LwlbM+Orh6AmPrY8vzVsli4JePrHLtoILGgPdhQ8HMccDqlWFzzqPfa0xtJZTfIIy3HsmtS1T2M1ex1ncFFYzNnSw0+EvdZP57V6C6YLIemg8OxQnFhEb3v67Ir0IUwtzEnkvKd+Ov34IzgP0vdAOb7VAvePTiTmfhTC0qDReQ3Zz4pPa7xZT72V07hzBdb8X0dKFvBIll5dxepuQI1USHuZ0Z2BHvgVK9cP/aFK40jI7/rrC5Ha5sxHc3EAq6RZoWCzXZphna7N/r9QBqVirpGp8tzBKQcM73RJmxj3V8eW7hqcUtKWBdhzIdgm4GTcLlU2fWooNA2Rn/5vfVWy5/OrMxn9dgnYMMwvJyjUSZeuARbbk3ATcGZqamj6R4f5ckh8TypfZDdYbvdE3chAs/Sjf1jz8/IuxnY+Tc8/qlovz27m9ZU7jSMofl7XaWFFBhvuILeKOvR+I9HOhNfp1tQgT0P6slt64UB4cEwVuWcLBTO+4pudPGPhGFnza8GydDSWJ8I++nNcgbYLajp24EGVKGGmPq3K8ERkbzB01mS3WLvoyZ/WzBPUHMwTzjyBqrQSLW4WNbNAnf8M8vyQOxPgiAdRvRDrJeazcMLp4dXq+RRDZR35BSg/P4zF2JwkUY6YokeeyWB2AxViLMX6678IWCmQpZB1cC7/B6KAg3oT2nl6Nl+TAFxhEup28dhO8er4gXK8mlkcbRRNE6PGRdQacJdHUro652mQmGSjjOGEzkwkWh9KWqhMyJiF+F7EteBbVAJUsvltvEbOuJJJ1lVh+58Yax3T1JonlTUuI9v9EE6E7xEW+ohGewof8MA0IgpnzGUKjeYkAoh75XoYurqc771nsLVaTwKFT/AjP75MZ8kK3CEnpGwdBtdB9mouWGps6F9haNMqAUJewCKwMsCmXs29T7maESF0uFxEUVGZfs0BVf7pmXvsblp2wAPzUgdjOZjEReiKNy1JatYEFNF+RCI0A+6ebpWUvA4NWozDZBLs279gYO1NWWVfChBhrKjpz1EytdHbTK8j5evmx8k4GHuQWr+RNLGdRJ4KKhzEi9xaaAD86aszpCAZrB5tYfnFS+jq+qNZuRVp1nfobGDbvKjl7bhoyR7iRTfUiO6Z9uUHxmVj1Zw1vmlx3FjZU7fFtr7v4HsRz1ysWNFnAu2uyw7Zo/lP55ZJ04MbZdqk0Mn27L7Lh09KgznwGB2TOcyngWeLTOeG2xN4ZMFvNJoTq3Grb5QMKb8hZsmG1TeDuEF2+46TVgThA6pzIUkdFN/EDQMrc4IZL5xhgu1qk6xXaVUHP6M5XZcgRubFC0T8KvdlYFvL4LeY6BjJe2UpbBvC2XjPYwk525U1beiRTZAsz857cw2/UdQZL/OmlJLfPucpJm4zlJ0gPF0+tdk5YGgdRBzcYG4W6SoABbnHJfZNXEDog+ssoq+x+VIoWceJg9KheHhYfeL/DphG0gIMZCpIvYZB3FV16eV4gv8ZlRgvibfvirTFPWhnrFEGZTsagGpanoFLLMZVzWA5tqI/+5EJT7mYWLU7KpRB1iO7htx3NBpV59IwE1w36ZhEPm2UNebmp1J1hUrhWN5+KS/GCKRqlBypQeVf7xt0eayYtAzhckylQqvnriFJF3jENLtZAY3tncCzse4s+TErzHX0mPRERGt1RKNxr5PAGXNyjYwvoxgYmFTmRwC4546PCYQw9MZZC+o2eeQwzKj2tojkhLnCO2VJ8Helr735dD78BIEYxTfYm3s2qta/pwqC74JQgqGlN+yZHr/bpzr96220pBibYScIT+Cn/+QbM78H0WTLQnP5sksbTITE54vqKl17qFHhsvQMo2u9HRN7wLWiKv0O5hnpwO7oBlYEbyoAqeiItV296P1NG/6NxuTZ/a7aS/Ruf0UiCHCl0suDJxVjBbsHicBtu9XDs9JgikAvT8Oi8N+xdmgyhMHIjzDCV6UW1iVwz6VWpaZiJLxE+PSqsBzI0A5lv0YhiJug8ql0ruGL/jmlFEiGrj3hWr2NsI9DVOdFrCo38ZTCDhLit49hmQXPCy8wAFNmSPjHTatXJ2/JjM1d/aXQPOAgu8/b8zcoEfch8CbfTTGzWj1oMH+c1hereveNwaI819P3VVFi4awEN0QkqBu0hi5xn/gJo6Grqr7MBhkbpbX9cffGNCVhu3K5gX24W179xLXwSpG8vOtHSMmYhmxMZUn3aDj0bE3oeZcZk03ivnMS2yYoXmvgWGA17R/tq5W8Lk5N5KB1GKX/P/p/0cgtr1JiTqr7VgIdpt4vvossxXQUkhF7d6gFlhVPxcI4yBtm0robi41/tsR+O5xco878Hfm6hbvp0elaijw6rHSZq/F9ILxzqsBIc4npo3AL5Y2CFTtCBFZGkFbw0vMLK3wF7BGH/9AP08yKG/QqEWr+JW8Cae5JSr07EdNxMFtHK1YvYuYIB7WkrpvwPviPs8unLP0Gi8XbqU+XZdXMXOwKLuH9iZxIhGRJ5rQqrKFeUBsXALwvr3P38bzLRHDDD5UZJtv4mtbqNqYSwxqqOgc9lzD3Q9yNJQxO/0WGrnteikzio4Nu6sy10R5YIY5W4MxDqly0FKTxfja4uo2It3E5nX3YT87Qoz5Cm0g/toMLfU9FJRH2PJcV2XskuZLxEt7/VEwtWRgFCUg8DI/KynnTUqsKwXDR/GpJ9iFfI+Ac8giG31zOpJlrKe0VkEiRWF9DN+6RZfTGBG3UbIIB7ljdKhfjEsX6wWO403X+5Dxqyx2/VfF+LJiN1eohIVczj3bsFNjNjYane/YJlOJPBxOiDjPifjmmfEBwrsFSQ5490Z+wJz6jbk5sKslgAE2oGGKlMWtiB7jzEl/z/bc5+By9J0DR2tV9zpP9K5mDdDc7WcefdnUfZ5G52hZb/oSn57YCZU86jmN/XUxaE7LBXxKPHSVr+Og/ES+nbcAou5hBnWVWa3uNhHmka84RaWrxS/pwBv/cKyVhyD3YPvPj+2Kh49nsTO5vVlwtjsJ4FX31i5QMPf6rXoJ+g/vq4uNASvzOBOtO91In/vYXA36pWjcUcI2GnYtd9osZfZa/n+3JJqvEFORRwNsY9Im1ToMa/PamUX8XWIhYI6YizabjfxllR2GMKUQI8RrQd6lrQSJrWX7WwRy2uWHY/2tUQY6ZNA5Vjt2sBuVU8SblOUAFhNkRE98X417HiZYaMKNmH6jcpLvwNkH0H18hPEQY2OapDWk2CRe1tGk7PZn+cQWCRkkG+EJp5NsM9VaAR26htFKEx5ZMTBx7QATMeOb0uG3r93MjYRgBqW0k6idpbLjb8QZKh73sq60aSHLVTUbRm3RtPu/DWws5QIkU8kJvntTboEqkK/YIowAgAdAdOhRVjaxgeL87SisRJTbT23Mcv3PnDRkEsb1fDAmvZ6nAIDmcZDeDysaS2Mg85MFPOQNkIsQ7Czq/dgTi6eujRqnu4t1GWoAGr4ankonIX4e1H0167Ntfjt8ZiSw4odyGFi5H3lN84D57yg1tpMC4+l2Et1WcLetI7Jmbx9L8sR7jwpxrLwoDTphqg/GBbbhEhOUKXQBnS3IJqmCHPvSUv7UugeQ/p7RGRjpYwRlq/b1IDL9gLlN53LF6rec4f3hUINXQ02KCFO8pstyP9x0dEgXv8EtHaWdn8lPqWBqK5bEyQdUoal4kBOOGQUR9+wI+fG/TbN08EypT1eaOyN6jOEJmR3DttaxATVzRYLMToy+7QnlnfyYwJVstH1PJ+gm56p3Ci3lWyjpQCjfJQj7KsYmMfQ2QAxpVOlN/DHYO7YEz9ZM01bEKy5dEkxbAQ/Gu1064hsPXSnXF7sfa1l4NiKM4nNW8kVzOiZJ7exlazGP7o/j5ljVA8YCqYEKERlK9A0SHBjZg6bhp8V+qJabnYQ9ngbicXZ9h6MiDBiH0S86lYM/0r57f+ZyhHje4L4hzzEBLT+d4K8l3TcuUlOK4SHrIjZG1cAQHhiTZ7rcxYUv564TZN5t8unrfEZHra6nAJ/7CNpntlaSgdLoJobLGOi9GV77IiAjjVK4+fIN1Y8KIs3kkU0i4CLjKX44ab+BY1QDhBHjanBiCEpRyNsTLZlY3wfVWE86LWSejCMVzksB4zbbBYmYXHjG2HMpJnPx1SYi25CNK8+n7/LgzHG/tbRRiZmnqbQ9ZKcFtQMOrLdpaHbUx4Pk/bo4upvpnrcHqyotZRWxAkKPbQ8Q2fzcHFndMn4LGnQf46gH8gKaMuQ3G3Ee1vlbYQ86rYjxtVnOqsIhqnVL/FS4V8LrPuJYV/XaL3HK4POiihbT+KX45KhQviHSiFUO337HZ36mjBy54S74V032lBKUZmqtMHYJs09pSYMGCwEqWyz+eonmmia7X6/y9zziSKttQ+VnfazZm20kmBxTGPh+MdfaLyEELjZ+ytaJftIsM972vt0463c8k7r06liUkZ/4vdMEH/rkIdgLDlaowsOvBhMMUzfGSxfQlAw3s8tZpaREQJtT3+6Amg7mqicnHSGRGV/957Uccy3y8lu6d7mNGCcuayNMhcWUNikZoWSnJ7WJT9VOzSdIlDHKpZkpajFJgDQL32kKOavOhoPAlasKQQ/q2wjQve9H8ThwiiQgMefsbQaqB7tBrjQ01cvq1jHGxYb+pyreU6GoGwq3HOlbGsWfe6FwwK/3BqWMxeP3Qr7C6Fcm+03gaq8YXm+5B3SuCTca/q8OhOxv5/TzL9cG75w2g4sEjLzq+Xuy96CB2lakAZe11kwodSxf3mvH9WjSQRxn+CcldYO4ky9O8pLLSoyljhvWAG+tMWbN2j0qyZFh3YS8faLKAG3BTsyIhCG0LKR2G41PdHHIHBW+IqT+C5NLDaPu5M2Dw2HTNTi5MziJmmoxrsOFELNXvWp0aSDmsrm2WL8DSgfV6XywkhyxGIzqn0QIHWvcl7JMoD/c+J6ps1aI9ur7ram2inD2efrK11EK1pZq0jQo+mDwNyMIbf+5mG6tQfjv08Cg+SGIJs3/OIm42qwfdkjJrMP6DogK663d6sdAf3gfNNAuywai62XFQAJKNy5fZfuTk4G9Ilhl0fQ2fEqH+on1E34HWGJf6cwADDjxP/68sXI/vnLGVcGBoGrkFmHHEnbOFU1AwSIpphUDpbZfNMEq1AzP9b/sbNARexqtVj0/lia9Uj0oguIUdBrogMJ7nHWo5Xmva/sjdI8BBYq6cT50Ykn6p5DSqj8vcV3qZYKqY7nuI00jsaPwULeCvPYrJ+jw/SfbYYZsnfrxdF2BjABhnHUSzfCITwHSuR3M7Ex71rqS0NL2RpYoeFtEwE2zKISQYHs7raZnymXAL0WlID1vQgRy1B9pk2nrxoJoz9NvlUpJbDOna2TNWzB3tfKFdx7K6YDMDd9A+CmqqbGVrejdAbFSMMDCaMQ3X8udrIIJSCGjFhGbs7XM8TN3R1DqwtMFuzRcdJzdiuJ4pDhdmzzRgYPyw7m2LK0OHai85lyLFxhaXDnOruYRGBRRb07fSsnWU3bmJQK8Q/eTWAmoBrl5JruA2tkCk72RfdNWUMORbKNwTZz7v2b7M/zFgqQllspvQ0y2q0wpE2jTdLxa/oSGbmRnwmPQXshDoNjGo8iz/5N35jldTmZTVmpkJXyMMmLrHxSaB1ozHS+gEE2Y05h3ypIt+I816sALhKs8j30cr4PJtsbMVlakq1QBCLAXaqkwonXruC4RNZzvpipckP2bGEzjDWpctmut8xGUHZVmfiTF75AUiCQETcTIVR2FIoRZWVkJxljOHvfNULd0vRfyqGmYXh0dCftD9/kgt/qkzdYmwNZTpp6AtCcWcaZ+tVVJpthtwYQ1zm0Aqhx7dVycudyNK/Cz4sHlkYZGoB00kErdCDnu9jE5DHGLS5G0KZxF2O+bBeBR7l2qydEVCrszoN6eMjIi3nMQ5knC1o5SXXpYlSkV0dKSI0Xv292rzO3ZvShSAnC3nWDrTagjoJLtw9EyZKB5y1pDtZf/BUJyaDwUSCXqvrFdrJ5bVhAA8pSXTmC0p4Nug9DgwIFsEmxtYsb3jvM6JsDd8PWMfRJZhBPdwsfrk7ozh4n2+cD8Q1AwVA08RarUmtIOY9hHImQePBiixADIlPjE2P1uMV9Rh9QyVJJqm0WCYPBXInJiz5NrUWnwB2w1Nmah1dMUSa37vn/SoCL3PabEVJCuQ7nW0tvGaVcZu7PackRnHozJNLJpC24FG1KxFimZDze78m6fF6XjEeibohv3QYAPIpxD3splZUqSgc2S1ydz0yWefg586CykAczCkq6foDpkcox2mv+aDPGKcAIp11oWKJX/KAhdNrwNEqO0ZZXigRk1s3UBONHcGTwaszgWtigkj3YKscITsM7KNeOWKnsF+klID1UE0FrJRBN1rtf4dU35ubG8Jrr40wO0Ceu34PuBkbQRQ66cnlKKsL0emfbTv7liuVvwhurZwe6/YzQM8KiBtmfxcGUrAdqj4+/6HdZqtUt3nROJcjGGGopm7ERGcMfvmpKe1RYiKwCSV8yWwyAyaMrrDvX09vfV0ve3Q9yIdvYuZ0yqhO7/SVI/99+V5tKJqCHFIEtL77a2iFVSmuo2qtiLPI3vuyDApsuvRfhAzzCeOLpYG2gM2njAtDKwCY6gm2R5Q0QGkjxC1yJ2qgIOoNmlQBbMDqb2HzMUMlFFxDyglftb7Sx/2oU0M/Rtz4BjukPcrlYcgNwupOlGiRiZj7UfFqpJz3etIgtPvo2E3iXVF4MY8/6J/Kz3r33IdpFr5YCvE6CwbSjOq2NKrKc3wJGg2S/cu7Kl8rgwLfJ+uvvoVuScp6rm3RRQur6OtIDY7iTynsAv6j2ozXaA2wFsSunz7Ztvz9dIW9dZKFY5N3f/qEwD7vx8NGUxarzMlKIF8wpwo7nh1/VZla1mkXxJBtsWPMkESzcnwb4e99WfvZkJ6kNI0MnfPdwKSH/7twT9kGbVqprNCo/xQ6dYEryh2e0+CEumhho9W7ebJTYxo7zx/SmcEC7Bkea4XOS/AvwQkYeBb4G+DjqhyZ9UecnfAdy69wHl0jQwwW+EBubO3eTg/+//bd2nkyouq87T3vojO+jAahX50cMA8s0HnR7kIHA8z0St6Ggk5MeLPEhbCsuKS5laMH9nf87QoUH5r0JjsOK2cXDmYNA71iGqFeB7D9mpCGVmZZgp1KDtzGvSyw3fieNwEjmH76pby12Mm+05icZdaMc5NRq7od8j/ADp4+tETUnb/Zr08pHfOEA+hBWPq+nyn6lhV6pDQFGw7qKMfQigVQcUeEgnt2Yj7fr3+DRQ5uYVCARKQQ6RX0oQWqcUI7a6eQ/67MXj/B8dl72r1PEhewFu1P8yOn+jwJH0K+iSNhG2gF8kpVcEukDoexAtytj8QOEAqQ3bcWGuXUAVuX00CCreFB19rV6riW/IBJp5MIGtT5rrFKUjPWFasNpSLuNP7aDXbpeBRfatUMGC+YjyjrjQBkuU5OfPDTzKroAjux7Z1GKskFhrlcovY9DQp5vRn4cv5maokY2s2S5uMCzHR+1jABp7tHFx0Gef5P/CItAsIGfuUYUL/nfrzZNafLGtq168HkFHD+vvOpK7W5q94I0Uz3ys6omJ/3OEzH7/amvlxItBM126eA54fRNkxH30sssdJI3Sjqf/RBKwUwBVhLclMnFQpnrhUGHBxuUXvBkwsPTphAMnn+/VqHcCFF2C09Q6KbZlIzI9m9Xj8q9g7onUUBNWpzPJRFOAbHMLiYaKMYFfAPmdUUfOXUWYJ4MMY0LSmK+FwN8rTAnzMDUCo9r3xmeBLDVL29InK7O5/M3aqjbp1DH4bqSal+hzIYKXkz7O/jw1Jc17E3EYSPL3TdlHxkddcMDoeOQfNe0TWT/K9AoxQq6xwlCA5sc6EXDj/yF75kX/OhQ2ZRBpX7Nyy7dMKdvOqEZzz5t4K9czzU05k6sqUCQzUFJI0+C6D8Kdh1D9D/5R0tlkSFRUEvli8UnWfUOKCFygoOl8B39yT9k47/N8P/SRyOuNfMF5i+lZ4WsA64AFI2L8N1d23FhMYKOqfw/t1qeUB2QjvB59rmJPTuHMwvWmYgzm+Ve3owzQItXoY/sxwf/TL3pNm98klbv1I0GKVu3kFbEuelYLr+AncJUi0ftej89Lh2TjGtgnpc/Ba46IlaIT/hKgYldOcOpzHu5uHqiQlKa9MlGj9GempDiRzN4diDXd+mLeXHF0j4p1IfFSeMNVikCNk7BX8KIMDdyDSWrvloRrCjZ2V23WpZ6BaaTW4ZHhpzj16epRNsc7YfmNIqbGaXQv3ohRjgDzOKOCiF3lnYF/yLl/pLbWjI57N99SP+tk2pMqnt6ygsbM/G3IIU0Gvo4Mq2q17GxtSWqtU8iTXIaReieWHvHdCmdFTDmTunwLKn/A5Sn0fHZpVfBYms75sjgpuFKOLlz7I9R67IVxL+Zbz0btYLfh7ONoEkz7X+eHEw23dTPkRFo75dovSCd3+1k+yTJnZvMexiSQvSWEfwVhIdrwqybfH0YX80JxPNBSIyiMxtrAYGs3qL7IVqXZa3Wb82RJx/f6kPYr4JJXmcE1+5O5x8j+WCYEiEXAPXGUhoik58FxPWEsKpxIfN9MJS9TQ+eMzr8YStdQkszQbqbyNHbHhmYnqrgNyMbLAJZJVr6wYZYydHc5yOskpJpdsTW/ETgt2qVz0nfPOKlJCdhI8y+GBp1cE4SHYWC0UP5S0qTXd8+2LCJXVCWOf0PO3HKHLT705cmVPtRFRoTEwnomJJjqMrpvVF5fHNhj+Uyd1evs4qPvwCEF9FlwmVTryvJfG1wj8E1MwueLGKdv68Fjqs4bXCmh1eXSxPWUpsvXbd7ic1nLaicMNrnymY7aH/F+eV/2scw9E2SG8ClA4cf4M8aFIzhq9m+FoHKuOuS5oez/okZAfcg2qbzYlEh7+wlqtudkgZB4nrnknXd8f0kpbvCLmx3dldP/rP0HLCZ+MtYo9ovv8GVdqmXS1RAk1/wO3TlE4lzInevgBullxQkDNbUAs3GvOpTUl8+FJmH4bn+chReJaBe2VUvUY+UX53usJ6Z1SRzM22I8VocbrjWW7wGTaBG7lVnlvogZLK7/PMp03MrdU7nUGQPYHikZMK4+PNViMq6uKGTYEeSpvnEMUxikHmqqTYaI0OkWQyjfvX9ZmaxtikHC+b65qr+PZ//oCu4Wsa3g28vHSUE3wKlrNAvRUb62Cp5j/Om91cjS+OOoILMVIakE0/t5skSthocTM93vRnv7fBVxvhKUCJBjQY2xKXHHjXlFTwrIIpBe+pRs9zFGH6BlrNF4VPoLttk+iQl4r0qLlvXJqLz1zfohYLeRHehCUNv0A9okyPR+v/l6jMuuTQj5ieEAr2xcoi9mC90ntbyLho6grQmoll2yySj4LDkk+hRTuOPetAhpec5mxVsouAuxP6iXtnBb19VcFfS/ojileooa8kJa1a8a6n4P2uLTD9mNWfPtAcCa5G0E4rJtA/SCDI6zBaJHOsT3Tk0XyzuVFp3pkCTX52Ysklyf++WttbrGV2A7VbP1pvfUMiCsCE8z+ZnzmWVsDsy3M0LvnahVUc/SsrIbiLpsAKULHKTEbEmuVPlcy3RRPcyD2FEEfRiKhcuMyhExvDZhLvATTnG2MEP5odR4NIkIXhGbHm+EluDq4VgKicGy7JqB0eopHFIoOr+nMaQ5+jg2EeARCnqNzZDVOpmwXxsXsbYgaBx04srrK3OYwYKUfqCwtEddMHQdvn2sJBdFyHAhfYgUyxV24twzy85Xj6rzRANUK0XnFGH6RwH4EMUGnlTcuZXFaSzzM2uybMu2BQleDme1Jd774uV19Pg4wc1pcFtn/r5eVhhBt0qN7HHxSWvc8D5Vpp60PgLY7QTC6nOQG39i0OPTnDnxCW3eNNXHXtbjMF8eS10RW7F6WQdP+fNzROC0Fn1yDf4lEnLhIx1IbOkKKDoRvZM8Cs+kV8qWzLgJ57D5L9b/ipKRnhcuqVGDDPeWYTjnz77+RCpSwWbiBIaXsNEMl47Qa0hhMA8H7tIsZd8clLrT6dJ6aoPzdF/OpNpiLw12IXCPgUmeftkwJfniAUoz/1GyYEPBEDPwwEoWmTdmyqPMxFUzsrpxvuBPitOQnP6w1N2hMbnq3MY+k9cuxX8PEH693LCiCj9q3z99TpltriOAL/7YnRCyemO+jciC06t9l1SvPszecf69YlA8VFdT6mpQzPUzyNYJK/XwRmqzoaqRuqxDXXQYiQenkGEGhBWWZqt09alEq5x7iTX5RoU9ZB3QY9YrgTttyaHQss8iOVWK6/kjkHiul4Kq4VkLBVZqOjEv+PEthZDPTMPjaIi4/IbYsDlhKV6CzAKKWG2PWHUZzP0ZrpHaXGOZrQrsqhDPIC1xH6UyVgieawlV+2i+sMBj+xVIQQGIrLjAcgYxO1rQsaheUyDxSg3yA9zpgW2Cf5jPebm9fdxBtrg5rmMPJjMPr8Dyzckfh1hMSWQdrWS+fUsLgJlTJzJ2scUrAt8arcZbMSMIzLVNSJLIToNUbuvkush8PPNCPPfTAXtqZjEgy/C+8IPjI9upnt+Kbr/Y9KhFA7V0yNPzwdXbHE2Ks/CI7W+wQYHj35LNzUj37pJIfwVWRATjZPFs3CtVIgGYjNyoA6aafVUMV7MEWEjNMiu1mDuSSB4gbhriMUuESjwgS9nBgFoQHemT9VjLdhB9ttlZvh/93hsjIimhkvgTb8DxHJJOsk/GyPinAPtegpAqo54k2ajiGZbwyzsn8o3wXPX+h5a6acrExNr1yvqSmX0nx0kTjNUV3AeksqDWLZo37MX0+XXqC9g17jR7v54MSkrWWCyxJxtZ47AO5Qxzqn16/PPc5gIlZZ3FpBKT64aGUWGgwDrkLPN5lj4ZBJ65VhzHE01psINcVvys9LXAGuXuzUDZcdW4jf29bwWN1D/Eq2U1ppAo/WElDW66Zoxhyh4aL/6s7uNSnAaYi7X/AqXVFTOkaS0i0qYzJy5sHToFtp1g+llwH+dg6KS+2ANqTByw+/jEhEFrEPLlhWOzVFsoFyAm9ufBsftFQ/ipgBXIRPTaMA5rwPwO+siIJaVLcaHOrNPW0u/eFsjAhXdRKasDEIjA7cntkCre3/gXmpxqqL86uQzGw1RJnftOYoPGZEij3qjH2KVAcMeM8AxOyiSe082/gUp4ujJfaCFUfYDXXV+TPHUnjAsdrPl5MEnxH9oNMZrTCNuwPR9b0G+6mCUTJdS8UAQK4Q6Q7BnWr6JFbXY7OYfJoigIsEL1sZoz2wcFq467uBQ0xWs3RWnSRUEvSxefdJer32Wg2zXGfR0hehe8Ud4tOUCBH7nw+RtTFoj5HuxZGv3VZHeu0JvwJScvx88MWV8a3YGbWvUpYSxiGk/3bpyja3LBJgikLOrBRWfzzlGvJ1vit5tOO0g1WbclWIU+24xDTj3TL6K+puPrUPakABcPm1JRNjUW5yA7NclBFOiBn9OxrQvkHSLpjtUVhNU/uXXDg3TI+bBCql/Hi7vfqcVcbfLDGwmg0d1L1Ge/0wFseRwtpJiiPtUwd35JhP5L2qo41nojpa08JRG+pMpRKgP6W1E0Egtycjp8cpEIJBtwcafqyuS80QhbiZOeYPaw/kntKXJmLq1fxJlQH1c7Ok95KeB/OMdlYaYohoJcQYz9ccYlHojgC6xLEu8vej3gpcQpDb5ZB6dCM1T3qqC64+hGAfxyZZhV2ZXcLz7upDnWkOMpPaXd0RD+XJLycz4P/WX5j2jQ2hYl/nCYY54PkTLUvz9wTwN7o3uJPolHrVkAITLQUb/0LL43npy/GWsrZu+gO1CyfaWT98Qy2nFc2E8bYY/PA/eEOjPczKV6y4bDoijae8F8oeXQCrQ2lPooYZPkADCLHpiD4rjRNCS5dQAlwXDGsZfuBZjbLFMjislReWxphqY2AP6TPHDLoBsdmf80jtsUrR2i+pd1voWZ6dOQt/6A+gfYoCKfIld4d6LthdZOPxfDgV2ouurN5YKoFlmwo4NyDEnEtbVmRyLMSwjnrQV4uYcNwlApa02Chhh9SsoAeqGH2FQaUt1LpM8AV8zuL8aJaqN3Eja8vpqCzZ0/UFVG6nHzsSIyPhZY3kQiF/iS3hrj5yedCRD4oWBcqu5pkeThDKFuvUgzAQ9C5udyW3N2ybC0kOHO76+BpwV3w4ejboh6SpQirR8eLRAfeG9R2X1mG8fmigrVNi4sUCfPB0f9U18km5yqz5t2gDRsEPiGXfW5v4ald+sY9Wb93lgXPJdAe9wNc6nSBhBU2g6vWWAEoqmhZ93nXPjNEugkVahMH585HrDD1u9kbetzhDcF7dFqgJOJr0oO5jCl7c0RuKkQ+iPDWHWBnfp4INuGKzq/MbdZXzEsPxXqPSVKOtJnBN5C715QdLDR7Mz6mK+Fbj4eckFO8qipcdPaW7Zajcq5swAO5IVqpw0fORejYFTE7hk7mjtoqS628mc3LkFJ4G09hOAU+IzPkymIwza2aX60WiQGiZWArWhtAR04WBA0B8mybtX+7g7/pC1Nm+19rdC5KXb52+pHMVk/EYuUf9BH/NK2bTKl28WpklGB/4JTdjyQnsowc2SZ6v/qqp3MQ2pUCO2GP+HElARFgXc2sfMhWTUWRmrO0pMpSVhSm6nJrpVW2iiIw/uxMVNZjR4Y07sXoarTAJZ8l3PxKhmyWB+Dvs4DYauQiiFnwR2NQFCZkOghRzvxR/703/FhWPljlUysGlXqLA/X2J2ZgUxoc0yQWhkU2Jfs595xxTifoN/0DdazU1cT3Nv7ZdTJDScvZCjncXVimPfftzE9AdEcGTiCt6u9Sqc0+hx+OrCHo9fEiaL3iX2ec8khMCJGizln6jO344dLxLaGnWQnJcFMwbB83wwTAUBfGP8F5QtWd1jIch1+il/80UbeRdRolkcZMOfJmTwAU6X0jKqo1uBa27qlB5+KRF1nrQAxo+CLesHbApPjoKoMlfy5xeDSIM5JQT2x3df4ROYVTtHmu5fyWKMfqzPNDqgUtxlgtxhP0aRIadhS72YCB+QGk9XQhzNJ8iEvbZGV74al+rdtePx7Hd5jTlgYiwTIz5rJD+9VWqXjFBhc1Q0zhs5LIy08JEOiC8ME4ZThUCQZXikgSWpLMpAJotdmxCDa+8Cf/dtxmSUaBmR/5Y+P7olmeMm8wzJTAYQ7f36IQU9Dzlvnivh3G30zQNXpXRuHL16+CdkDs5MoB9S7O778IQrc5XubDFMWvSfWbtg6p10fE5vvmni2ltVyK9oC1Pb8bHWKMYFNeZurMK8YY3mdJ41yQBcotmXpCpvk7cc+xMF0zGyxEwOtWXwbfboyCgE1mI38Me7bYNRkcJXaImCq02wGCZKqiD7DPf15+QBacphTS4IuXYLF5HV6/kjbDOK7sAB92SafmheM9o3tWv+SPNQzPs/RdBMpE5w59Ny8mJpYHkGAIkHZ55/wgaHhwNUI8jSr4PQsb1ckfiQFS4ZAXdIH6D62y+uixrzE2/2lcVYtYCdPSNCL7Lmfc5ryJd3cRbFgCjkQgYL2oNPHAbA6Gtxc+DHAqzZ4KedSdJxePaHv2//bxFeu1aCJGYRozEMsOnh4sUj6DDP9166kd/iNfpA9Je2tcyY77Xtkcg+rpRnGoWsYafwsQzeiqdBSCnMlagmtwzTNo/RCa921UnvwW3DHJnNzzxZmZd7vg7Q+GMvp43GS+nfoHbJgVEymmwXdH5oB5cO7i2/UK6czNEgPt+RNsm8o8GPoVaaCahERpqZtNwNCfUFfzAyttkEi5laY/00DqwxPGDeJFFM1E5+xdSl1S3c/x1bc0FyPHfk3nGtFINw9+hypnBJ6HsIOdEKgoZdJBgLIqoD9HXSS7EmSRdiVdeP7zBYZlUt8zGuuY7iP7buV/W7VCeAoUCO6UQFB0ugy85j0lek/D4u/5lWb/8LXvRXzSXLiSZ8/cc1veka8m++4JDqiPPUvJT59Ut55x1QryA9CTJrzutuJpOp4hX2Gtyh/Z4ddieoFUIFpy4B1dKVrEsPBqdytK4DPmQDfv1LPNvSTPAoW+qlAG211xSMkW6QymI1Y89xuJ5zZoj1WhjU/2ZBqfpOCwb6zKmVr9jlg+DPz2d2LaTqZ1fMTycOO1XkN1rl8y/S8G9spCAx2Fp6olrRkfFFWZhtTXg0mD7h0DuanNf/b4mby5BYqqRVYFEBwfmIk7jCd05NjZ6AGDNxQ2LizoPr61vG0WIX96aOoi/1V1+RxzbFXmqZsbDpsopFqZqX8HIL/GKuYmierQnenDWdDtJY4UXqBwG489xJTLqNiFbrz2h4AKIOgsegnhyX81dcj5p4rrMgHiA0N2k6pu3s/agf0Bea1i1+3rEH0drVHIRISdZB/U0+5ddZ5hUXD7MBCAKngYdkryJRpgyLw/NMzLZnb3A3R3nDXFg0RbmV5gtILT72hYhmygrcthdrifYAgSXhRUToGGXY6L2d8pT8i/Q+tRiFiRNq93+gSZs0SyXVwz13ixU+ytPFl5CkAYlSZEzn1JvbkjbqNCU1w/2+ww10bNL0R95M88XT4fX2iHV4YL+fyi9IbpvxBJAR0iqyTWVsRns8Dh+YvXv3hSz8nMrjXgY7s14GUA90ptKpU6KkLMK5sT0RRKBgNSLBGfzL1fAUj3BMQ3X00ohnbsP8bhkw3JUUH5vuVVpxzyyK0NBXcf/EuZIemReqeAlQ5FRC9vWsYBVlPuD8vW/GFlPAs01d271U68nNFeQJBOkrKArZ1TqRxBP5+n71JIyJcD6QkZf4czU1E7PNTrRNbJJ3X9/oxZyppM7C0lwpsDYXTmlQSGs35mdnHTlBb6YT+hEQOaZtAS4MXIN3XZpaXrvv+FNOdVPfja7UZAEne3jpS3YhZsif8Awxk4VOoepXChreNdhlv+roiOFjItwFGKWiUI5JMKb8PxaiYAz1vB57O94foaS0hHriaqPIBu0q9Lhy50wp13DyfRrVHlPgSzXM4nGI7KwkmeacwUlS808bc9oJs/2Pzzt8GpD0RpxioCb00ZYpW9SGA1sxL5ZQXJBlrFOe67Lklmd6VibVkhHUnMjA5s/tBi/DhkFlkTLyFaZ/sabYXpPVNdpFFEXKEF2imnOg77d3pQJPT/SGSRgBLZI/rzlUEgiOMAsBm3St4eynQ46f45M0kYoJGzjgD9uF0i7s2Yrtf6cpVpmDtcXnwGcW+DbrxwVjQJ5aA0UHi/lSvBI97whtRKwHPLve/FW0c163wzw8tj8s8iiZnPvuOadDCfNw7r1HGweIYk04RGIQsMebUR9gTp7MU2OXB3fUARnU3ysXa1H6Ti29IkFM/ZOz8TFHcACwINS7ioD/DC734n0Fmyyr3Lp6s7jFyOX+fttj55gbI0erT/AO5GYITzBsqllKJKd/hBqktcUfLbXbwXdffIJZpxuyW5ltff6KSF4XEuA6svPnrRL0fACccE4/YaW5My/2VkmYEu2FS+Huj455gmmDK5GYf+0nrT7eVjnfutAV04RomudC1736ILN0g6ZPZDbQtqakJXv6VFYp6f+swCZ7hdTdCxOTVtlz4nvNuPEvxPVbkhhFLvT25dZ4izdsl45xphDW/pawHMWb48+UG8nm6F61K2X+UbArJFLlxJyxSIPamUdaDpKu5b4u73S1wJtnvGHXAjMthVmTatL0cxFjI9LOdD1kEbzSZVXu/qgt7/9mwQPJtZHX7dHFMOqqDuqSd7xMywjU4kgJPp3mC7GST2z6CWuQM9Gxw0swbhWCNJ7QYfj67L1pOalYOvDGhBnz5wtdFxwRh6CkMDqDVWERCi8L12u1OVFeyBYYOZe1IM/CahG5NWqycihVfPKA5atQyPY5/E8jQfeutfviVQluvaazpO+Vp5uLcY8SiN6DGwawdiIN/0nOj6g8Nic4GWN5mcB5eT3j779NODfjuXyCkMfNhneB8J7XIwynXmCINUiLh+1c+bvZiwlR2ShUhcHLdmg63QTckGrt1t4/TcPzZiYxmuovkYAdBRK4Zt+6l3enhsv7R/MB8T5ytE+2DcSLtT0HiNTtpL8Aoaj9WoS6V7Xtm34oEY++rtLnpwJ+MGtPHjLYj1DMVMhmomFIoEf8yVTMvNpTsUxUopOUSh5yqn2T9tXYgZd34C5qG8v/SQQhz2gHu6ABDAZGVvoefM1b6JLh0hEKQSCwmRepRKM6XTZvXYjAsyaJ/TFyNGatgEEpFY2QYbYX+rv5IG8zRHYl/WiSrwzUDJk8qkIIHm76Ir5pwG3sOGM8MxoUUpcyouU/e9TEus7t1vpFuXpqbkGXx7tOviMXBKkAtL0YwYZzH9EtFFqw16Q/UfDxqRp2lW3HG23OR3Mfn/4uGoDw4GC0AsbGZ2li72nPU6jQkiEzh7rioGlspueOG2cnLRIJVhJuIJRWJAIfaGtgc6JXCqaTPm5BK8LAOm2Xs1lqCfih4NpRl6Z09qFYaxrKrjRL2FsnTwCj77oc2F1U6y9gMdaI8/5ZAF0fGV7QPsu4wd3zr3b9vXhFO62yYMNnpeTVY0Hto4EEDBOw6AHeUhnzEc7aeV4mB06MeTlzrxmlBagXPx2ISi23EZUszkhp75fISuMnYWs/q92N7yEGTJOjhy0LMUx60cNXcz//xn713glUar9xCrYMlKcEBvZE31RYVognj/UfHaLuNJ+TCQbXMkVzb0JsvcrOqTvJNSo/Qd2EN20wu/HHY8PHeKO29GBaUV9pnc4d6lnNxeFP0R3ROh/PpVD9xMxrns3Gy2J6Xjxh2gN76tunUhLFX3hngDK1hsCDcfnHuJR+p0zjJWWrluX0vm2Tk3D5RRJ+dwXsx1ojeoXreceoDiXnlkJI6uP4ABT7dJwOUTn8Cg23TAgcG8qFCBGXpp3gw6cOXgl9klHqTGZfuY4JYXcwQ3ZBtBkevUTsESkRZLq6rWxfPycHGF1Kwe8ddC1ee7+XnlQYQEvGTqNCMvsTZAVln8f7AUxEiFsYuL/tB+g05DAU0bqLg67N2LTXqmg1rUf7yJwq3QyYVDgJJsJHINR2g4ksBAYS8Yov9Gst01nVSNFNhW4xjwLUiGQZukZEM160rYh/igx6EHHB86swmA1oNuxa87tOBh2V3NpW3R4Jey5NeBn4JZmTJkJ7UO1xMlgXe16cb5qaMk+PZOsQceFeOFjfBO2MrokPpqKg1FMYhxNPq5M6GxgBG9dfY30R+65fdz38hYwAMEY2oAZHiCXncfydT21XDQhEzhGAdb4PlbRjrQ9ilQCZl4tZw9W3MbGRqG7461VFyptQgjZAzL3vNxikvrVEBsd352nj8nDqlZQSr7MMjt/mgiJnN0ckp4prYlGKQN+4nRLJZ1M+vMWpyhEIGim4UAfJ2cl01h0ytVhtXUeo5Ue3jz7gs3UoUtQ8VexsNvDasTA7QhyuOFYmz9vdOSCoq/3vz2+1Kw8C/PyyCoX5/6303Yj24Yoi0qzRE0ilDFB2BW6NYq84MrGc0SCxeoFcjkCD5m8djGSJPJce5mdqDNk+zIz5KpyZaReZJB6tk+2uIFiyT0WwLJkoobgF+ZlVQNT0S8VBrDh41Igyys4/eyomM/QQ2zZdDbzxwJ9Td6NCeblb2AZtFORbsrMrpA3wgQwMap7fUduZ4cFI1hV5dUn9G/ZfupDJTe5TLtnN/vYP59TqSyw1jW5CgL/S831qWrwryGwa57YArfgEWvRbPc7J45gM5QiIw3fb2EPAF+vXWsKEAjjnqhz7GQ8JRRFcb0DSoGwJ+y6HsSlZvg9cQV+Ib9bJmjyVlQUuLDtZEGEXtNmxSqYV2+GaxFpHNgv60cUl+CrKREp0JaxqZ8cmxpIyIX+wGRQSBnePHXz5qe+l/AP2dC8Owmpif3PBJQUpFVZWwVbx5eU7zeMRhwHUTWJbaSR3qzTDZqz5XMlH9bkgN/vLM2Mzp79FWNdqwQHKGkRA7dB2gmiau4NMylWaV4emr3B8ur+/z/CyFd6DE+5wwXE9G24c/p9l5Z22/f40hdQ/w2FRvaTW3/Lqc2XOLBp7W7ge1YKEb/VOdVScdwpB3HMzBn3+H1Cd6NNDo/qDa+DDxhidqlt6y+AJ65/y2bErEL8iLKnlZ8sMIcXl8VNb+hpokDrVA7m+XgeOpP3w0PtFbFZG2cVGTJo4c2z+nWZkhWQoFHm+kMfFH7SWZhaV2GD4F1SStG/wl+kxNgaAIHrWprU5gC2Op28nlj0WFBV8El+rMLOhKZ9EaoC8tHdDDCfjj7pro2C6Vq86j12esoG/bJTA4PTVDhrNK/L5dWqnzfVybOUZtJie28AiidtzW5XJpndiYrZ/I6mRHkPsstNOhXbx63F6V5DpNKU6qMx6JtvTy/OzSrotzUSafdIgv8UM2PCYyMHGJKog2i1riJsO9IsOrXub51umBgrWjf/UpKkwwW4hO80dYyZ+RGVFdxfoWfNVGMuQnSXvMgFu64Q/oQlHEErlPDbJ5GiAiCNsXmHY3eXCE20Rg/qTD631sJbboQu/pKPI0+ZrRyPeTKTyhIdcoTSZrjCijTs5cS9EC7BOui0qK+Ve3befJn+uCSr7kMIV0EDIhGSV0T0dar4SVK5BaTf9fcxdAj6d3T5zKbLGhspjqNnFnSi/RbHQEE+XNi2+jxjXt0Ecm00+JDSXPeqOwtR9cVWwOtrsNbLNyKxUEpuOY+gE+KqRdlGxZWkxqEG+riTNeOElktri95r8VqiCuVX1pW/FA9GP51LcEHZ0w8in+1z4LxE2PEvyAtMqZz2NIKlVP6t4OucKD9Vh8dcuSqBkjrDNRbAdBGZuj0dqKN9QZ5vt7biY2dlzE8mS51i9am7b/gttvE53oZVOQBm7WSwt6K3YQDWepe2viAAQ8xL4WcbAKIyvJI71+jyYV+3VAhBnJTNPOdwW++1JDhodT3X3/Hj1YOFzrRNLH0iJgeosv9FzXg8Hjq3MWXxL3VsvDY94JK6jYUt9i+2QjKPDiRWTUUa/1Wbt6ZNXsrQnmhfWpygz2O/5YGEVki4A9+MqY6ZrJodr5DoG9TE2LafN+0ia5paO9b042sHUKQ/FA2xuAa4U/8yKIHOiJWX7LexgqsA4Nj7+UF9Kd7oWrOaw5lYc+8GCe9MBpxB6tLe+OJW2wQheVQEyR8iw+5mzZEfh3hzCrkQZxpO57PJ0HUz5+XQUdvGRHhuze4LeFguJ1o3qOKbHUZ8MBsK64kSzsXhGOl+5lF3xMyl2pwGMWW79CotYbgrQLXQSgHdISGZhfGl+0hr/OXISsn+5CXMpa6U1sLdE4XVZMItmBc8VAx/TrpbeTJUJyZWaWrKDj/xtPtSgUDM6vVUpRHgl7ZVsINPOCduWHoOxAB3kbBC8MuBJ3g8KnEJPWfv/NBCY5I/j6KmJ0J+MrKSUbeX26eJPtIUl8t+g+UZqlE8r3Nn4DKjSXL/6KD6vfxJrbhig33s9E9JAdzZbWcIMonkjtb7n8gxz88YZy7Z+mAyBeDm7whHq6T6WFBTkwL1OKo1u60Z5IpmVyY2hu02VqXPKvP56C1cZEvsE4qBwOS3Dm5dHE3F9yVt7ARXYl5Uj6tJxmPNjC+o9gLkVAOgafRzHTy2HgMAvxDCtYbkYcLAkpThwObDXFZSYyeJVlkX1aw7O8pKxKljLWb/hiK3HJIeFQNhdPmIHLSx7kNs2jgQnXTydvWoELmALRPnpXI5ICd0Xp81cY7CiA7qFDqF+WuL8mRb+tsfE3v9J6bdRazpUmCNWfCNys9RvOJp5rciZQu18szqXcUJ3dFhnWFuyOsJRsy6oUSJHnUt4zl9Zi7upVfBCZfKlsAElCZ/ftz6pOdHBUxUpF0H+OcgjnWon9n+uCb5V29/lfPRn7HducYcAup7R5eQgZvstQmy/0GaSTcMZ7bRI5t0Hwc0emg5bchCdkvf8OqRsgfTd5RlUScyRy2I0x75tdnyVI9I5Wv5VJDEQrGbAuKjCYlNaHZjm3Ks1PCT+5whnCBiyQklRgbgFzXAyYjbqCa1j49YsCrofUldFCd5GUOt0SxjggsiLn2GcXltUX2tCJvX7SjxGkAqgWNKB20Ct35/5bCBi8bc5UIhcugERNA2tYZs213njKG37U3p/XxYJv9AJYMPC4KAalWlx4PgMj5FEFROkn7IFfTpYlcFvw+lLtkfFnuqsXFOqLHKwC3pFgANOyTnN9eJh622t0kZkF/dVb9a/Lh0L/mgzx2oZIpAHdPAQMRnv0K8TmDbM+NKFp8YzYzBQHvJT2m0w89ZhGKdDb4lAWGi7xUZHBWeUuEDL5CCafQr7uDI5tlJouV30YE9gkKBfi7DwDQtVXRuER1bF2v6CexKHbb9aG/2Ce+x7KqKb9yJGYGmtXUiC4ebQ5/HtKY9OvYv/PZNdoXVg/SqAyHSY/oNNVqe2Yp5EGAY7ZS6K0VkkcmVrinpjVx1A0GSLtfdvdvBQ8xrj8ZQTCr/7dzhJhKUzrEJvYsKKyRiDEEngvL3H3JnQxsUcW410LtPk3giASRqCjM+9f2UDSel6IJ70kDy5XQiPuPGjUJhcNOoV5uqI8iRcR7t5wU16AKksPcdPTSHjJFQBV0j0HUyCYQscG2b8uKkOdD8MKdo33z74Xes51IP5Lrrel5cvImvuLE6R117na5jZtIGlSkAObuySJctHzDwuqjX8CRwsvBzbxKFEatsViUR2NYk/KA8Qua+OMUNDXUt3WKP4HdMfN0l+hEoSbAVX3xpSaTO1ivVGVXwDaUqpgCxMiHTIUu4iLjLSYz2eilRJNo95v+qZr/6aw22uL7tmtYTfvW6YpH0Dlom+TV946pVHa2AxoNhmBsP5FQZzfuduYEfSByMnZtA6U5DPWPbXO0Cn0Bfx8F+rRo3VEkN+6NJScGfWlRiQvIwkGG6LassLeRyF52UtGO5uYlZhu90XfrZGMuo0wca4I1+aMZW3PRDFcbzhgzdbIOb0OK2WygD7KE2whS6VHJLuH9yt4yw/zP/KuCfOQDC/3HOU+x/TRsy3MRqtJ22j00BkFhC7li8ZJQojnbOzMlqKn5/VvJ+iekEvrCMlsrDpVfs+tLxFOpNyeXrAYZa7MdeUC3LbUhZ8jmrA00VIlURhZ6YfuSbotNTqGN8khbL53jWYY3+RS+Hg5SwByfhh/Ka6Y85sGhtWytEl0CpwCZCdxJTweYdFbHT+XzhiRhcmPACBeQ9aZ8NMGU4DBwsDTeSdF2jnv98pwq+kx6TBft5OR2WxiRzeaRg0sMBVz2hzjCbym/ar7tW+LGSWFEc8br0WCjiTTheZ7g0BZnYbl0sLYgfwt5C5/IsjupaYw31KibLInRX7BSVV7vFhOYKX80Z2Tv3xR1wCDrGCaOBoWPhHCYjo4jCoKF4PNIgUdtP5X4rtiUT5TdXEwa9iwdifsSoqNAN01dtA2Q5btDSMWggUQIGpR6cBluUMUGTLY8vgl7jXnLPE39WDMHJdwby5XfCtLlefF2BfwVISe7+vRlp129rvjikb/4c+VmHlIvj2CWdPd1vXbH4bEjOTJ7+r0HtQ6f3JHfovquYXDHXJY8eR++0r9fTkUzLjw4dFN/QnwwW2gDs9nYwFOILRySN5j8XPROtAdni9DSIWrmPpQTpq7ewjor0IBEwi4tcJ8jUooDQLLM4qZ925WxT4VqKLFmcJhBFtXJzGq9I0Sj6ZOuoPXzcv2GKznCUGMiFYMcBfExFEj/z39nDISae7xbKDB9dBStdmy23BJDZ84WWvq+rUWt9MchoIF/3vDkgrsG5Cd0LQ6nyQg3uVnFKzuzcSbh1RstslNXitZiVyUksPkspr5ROOl//CJLjt9Fuiwr2CFBq3IroC8nlorFRHdK4z/MocQcLps0lj+CCBUlmB9BCbg1zbdgJ6izOb756plgC155SQ5epgxMPYUPiCHIVwF/WWebJyaNeYbCVtY4hklC67AAnkC4GrbKiV0nefwFRieMhAhHeHxq8QUYKBMB0E/oCMzt7G23GfWz0cRWPO0DqWrPRkwaJIs46zfW+HpTn1GBOy1DUm1J1Xlq9M+4vINBkix+8X+fe7Vjsu0C9BF2kZ7js7hSvXgbk1tGqpAkESwSrxZpqgfuCFftbXGfXlorIVPeJJQgv/aMfKitv8RbKKTO9w0x/IbjcxA6Grq1EkmmQp5sNwYeZ/ZUKOYeUY5tlydlDZFvJb/B1mwfmQ4/jR5nltswQit/no99KLTkLvReauhVXVFieYwOj7UdnXCfCfebPSArf6U+d9Uith23Dxj/Yi6VsT/rrVD5GHpk2ya6zaZPMtjdubwQhB4jay2EC/vtfU6BDPHNeQ1dCAsu5fLtAoA9YWNKZtFpwovCFDbAyffQCruMsJO1ToyHS3zZLzKyotKRgnPubmvjuDOFe2hCQ05Fa1uxx9kZJU7eFwa7FRNx6QmSfnoSK1MULAHDQhmxvUwQwulCyBHoRbdugo87NjkyimUn6pz4dClyqyJ2QcyScMhM8wOke/V7MFKTIix9767nXp0/bR84j7QEpUrT+UpGo8krUMgF2OpRS7GD2QUUkWiCu2/gOJya4EvzvyglFu5ByRYFLL8eMKLPslKsCh4Q3lXgcU+O5q9UbV3nsXfBub9Bf6FdqyuK0Cf7xgkDfFzCrdpZYlQodkDlbQxBD0635lgDTit1D6WCwJCq0DfqrJhNyciqyIFdZMa04osEQ6+dF8GkjXXs9Jeu95uY2S6PvzcTYAQB3Z2U8ywjG2UO0DeAwZuljWovu0QbRrx3ybmVxpTS/V0JrNXRgeMZ1Lo1Z8xef8nSl8t+gdTsBHslYR8BlCtQFGV7UX8lsJwJ/djjxs6iiG3iodI3abEl32xqYTLOgjE274mhaSwoJxstErXpuBT4Rg6j90zJpx3NpJI8kEEtzrUGfbsV2RDUww+ITNgwZfjKHJEFKLg58azslAJIEITULECksB2k2RHziMNBuZiZLssQkm2FDeMS6tyjuU/0ZsIhpFKvK5TNML/ERKxyccbLkCDeY1FLYLclO+7iryJYmGE4f+a9Mmcorvgk7Ygi/pTc9d48yjt3yGia7gwbFWWPR9f+isvbG96Yo3fdE+NgbNHCYTSO+mRJzTFqtj4C37zdLf2nOLg6yPoiIL7RdxZf+gkd3wESj4lEZSII02L5Dhf15HS4YSF3zo9NXjOaHCVZ9G3ribw2UdEaLOsjUP/1JnVf85c0cngJ8mOtr9vsGmBpUVrqjubK3Ath4VimiqdLQKYZYHu82opKouezXPD/V0LAyB1oUOQdmjw7W5/Z2AWFcDqiHLRPeEWfhiwpGfd9jpXfqodj42e6A10DSCx7Hob7snBH8qjmL0SjPKauFxSFvLo9loWnlwVu/Fhgh+zeh5ywK6D4nkC7Qn00RvzVd3xybWviT6g+84fh28y28S/ZRMG7A+3F98M22NrReznrJVsrcHJbXVAo/62SXH22ntUkj5fTI14Jk09paxoAidc+Cxm2I7JVJNPcSx22obllT70pnIkToGSY7XDWpFj9R6pKwaxmPsvzszE8xkFXuEoW+9bINaPAwEkRK6v3lGA+fVkSce9U4NB26GMkgKDMdeitBEVtBGlu4qzZQoamIbtbsB6csZB9+esBDgdyxPgxVgRB0+vP8Xs9ojmqCR5+r5EU9RoGDvRmefUqANo71qKea9FWII6V/MJCjraQI6t0aeTHhDir9dh5k6SSHVFFFU2l/9gFOZoT9zHIBDV/kwVRZeJXpclyH9N04/4aEHwm1Ag4bLJWaI5RoVcZs4c/wP4wOahdm9wFzXXPo/8zSBI1jBc3dDFP2d3Z9pAqL1vsoKlIHVyW56Rg9c58xghKTOa+O0sZ0uwZR0+jpRTA2U3l695XUi9B2cDwMjz2+8d+6UMniHUwhEwLEJJvWvgXeAdDqRtLCIgWBytajcB3pNcWD+1IfE1g8EVNF5eF6dLnhUFIRpOQ4oALAkXHUc6YmJNIKcBefg0N39913eszbiHBVh1o8Kw+YglxkPc4dBpVyR/tnIoaRM/cb1Y1CRN8ph7KhwgRBRhJSddBLpTIOV16+TMBNuEC4mGEyc5CWsldVB5GE7eT+pqrywp8/nEtbv1bPDGgkdNqEpgGps2O14re1c403D+SU7TFtBAC2wupsyEm+SmGg5prnZ4D+mkX5JbKBRUmEtaDrkgWzjLdvlnJSAqBJUjPBPWKwGLmk8af4SCZVIc7LC7YOpvm0zz3OGdKZ0JKyM8DfR/qp5v0ivWVXDx1+My28lkoCHLqHYw/brgMl0L77P9h3/A14E3XgdYSXnsZOyECAMGBRQ5xFckNZqCrJ1FulgyhjB7c+2aER+4AjUrtDZGYWYCVACIDYvzhHF2QtFVuWzkRfzPt8HcbaHT0hDFX71gP6gcf+NW4F3k8Q1/y73a3pqz8uR8foJzVJGIYWC1x8SjxO0WaWFvEQukjW5VkgPEZPeW14hoLLDFY/sjS6jWxXNl6Es5Y/wyZo+5gUAMEaGwQvd2v5RJ4slnIn9QTLArUXAUL5aridfAASBG7aMd8J6Xjvm67yU1f4EDnNA9GDKfjOy0BNaxhEYP6TvFmOyOigF6tbaab3JcJGZ/YlRkRmQ8d/gkj60A5g39v+xupOGbSHFocsqebbFrkhZtXaK+0KsgzslPpiWF0zEgo4f143AjiI/JbGNIQXCMU0AJQLI119CrCwwVskF/9KPJjIQcepbb8cdMIou8kuJHn63bOGiF7QKlhpXuWx+/tZvzt0R0W3wPmzmC/HR76taLQtC0sUNCs2xmHYM08sCaYXAf/PyTNOx/hf7wDo3cMewfG1WNKZgMqZo+X1TbZeeORHGsQRd7/mH5/eqPIjjgPSWKPdb0CipqqxlfB67FKPM24Yb/J6bzgwGSLiUbPMS4mTE/p1IJIW5CFZZDPCksJz56FRVvXbMXTObWuzkc7xgUe4P12JW/70esnOLRZ0Zss88CtlR/YhG/UaLYXQh5VeXr2hshdO5z/8pF5CDRubK6KCMBrHanLYztzo3qg2Zd/CipBKuLmk9U5DjOiZGiOkc3LyBG+2iwypV8oV5WRbTd7eZ+S0E+OGMa11hs8GRIrYOFDHuSzh+jPOHYqX0YB268qKOZ9KnRUYq3gr58b1AHUdrOzg5z1oCXLK1vdRQjUJ8704pxMZVLEdIQo97ZfJ9t6qiA7ZzLTHFnbwhVXoJiiMm23Nks9gob3VTd7K0F9ICxh/JbOvDXiSEk5z/E54vFLBrb8BpybhcY/D1vygl1J1Mtxk5TtkxVFIJS93ZJwu01ZQxRHY8UvR/gGDHCsBA7eojH9Jk7Dv1YH/NYh+INwrvwK6DEyS4Cztekl6JIhJAvda5ZR/riNmgWeDBEQaj00Am2GpwpefyDfLG4mEqR7QGtIW1LUAJGoxEd+nGlhgcto/ERfs5MFOCY6Pdhw0XBsPVfXLyWOx51buhCt3uDpzHRxITJ3p7ID7/OoYsnxuDl+0q3ld+FqtTwpWG0k3Ska0vGefA7jclGxJsCBVaGqQ+rDXH85XlrsI/ouPHyb6CwJwo/cntKWnYhUp4X1hEjKlh1cBUkbhDkMTBxHlhkpnDPFZ6uxLMTthWk83u1eHB/+DL8g6bWddrUUyPBVsIXBLB+4C1qEpd3yAptcHSfkW8nd+KbmS+nIXJ6qtWi0BZNwrxmWOKHl8Ab3m9/g9cdmPoGK9lQnMxS23IZJ5NNc0Hds6ZPCwKE3K/kIf57s/+y2EVz96CcHP3okfJ5bhfOTBg20EilXdAEmXgmF/D5yNs++fV0384PyKW/Etf/NLMkLkt1n05ZdCeHhmsxNsUgg0AhJbwicu+5f1oVN7cGSlTUC9uXtPxCIJDNnqdU72U0eAvoAabrhgwma250vX507PPFizRrfzkHou9wwX2nBdZkNUHo7iWOZXQ0iMpxss9XrCUu4lJsaK1NanIwpoQUZRRXLSXhK8YfFC485szexNtgATdJq74WVItqXeD9jp20T0zE/aF9sIvxV10QlGwrCi2br2x+uoXQekevxvKBqn3wnP/9jPCYKgqlfwINZX7jWpCVie0sCT21Fq/hlDNVh4bYPU1S3NthRkbuqIDePf25uIiYcuQ3hdC9Yl3T9K0JwORaWiqQer166ZzfX5+gwIALGAbXrfDuEBoOnP4xQhNuEHS+Ip0wjHbipF2tCTlOIWITsYdATHEJAcWE1wI2kV04YoLQYusAlymzg/dr0OxZgNBzYHNftO8+5sUN7L5iK/jwcXQ2S84S0TSgkPqjRGZQMNVaH5XDuePNC7YEInz9Ww5ZsYNPnG5TSkffcOs0TtIDBnhjlovVbE88XkeuLqTqiDyYWvIhOGhDFOo5upGZkghB5MrIxIspZiaMia9+0bq5gFrqzxtTR7jOAgW7iy9lWKjLIvM2/id4tnuyUg2tb3thPA9ISIuX7+nnaFV7yQCDO0fIRMNqSQiExGcGWmOcIC1gQOQPFb6r3HGF0CUkBNJlWV6xx+W4YoHpV6pkry2HDEdDyFpbNsWlOI9Yf/B84jiszPOhBJV2CxXBerPuBmKswIFiM6vnRDmQKW88NdKyDlD1dCC7g+gKfoJ40Fc3r8xOKqkR7wKZ5BXpt/67/reEVxisrVBKqU8pV0YUVhEqureXemxJWdF1QnfdNCgQxezrw6sTP8Y3ctr6IqIDAzY0KR5Hk434hezlBvY9S3WUY+1U+DSCRovUEebwacKuXSPeDhjr2/j0queEbA/6zv9/eF+WINrrM3+rvspplcS1LvffS5XDZ4qgY3PicYZGRGjla9Upc8MuEl/OjdUWLWqmgrm+Vq016QkEirfUGRZ62uBm71ASUp4sQwOgNZbPvxXDV0lbHlUTv/3NJhAGXZqnn9gq3azo6WSQQxArdI3/TYpTR+5JbpZ5Dmmt1zrh97DhKNc2mzqazMCZmpYrFnw53KBXvB03SaKYMvBX0G9tpuVMJvx2KyXCeuay3n6JDYyu8isiYI/IZZC9i6BvjmUhsqqTaIFHdQm+HI1SANtRoQGSuVQwPY5UBBYUJg/R20HaLDmwJbXvd2nqF44+dsxRckwMghBgb5Et2Fvs2oOKGXrVa7mGw6BmRm6qzVd4mtmANuE/Ub13FuuEHcPcfJIrwHr5c+Wn1YRHQgovTRAS8Qf1G9GRC5SL85ZNmilP8GKNoRHiQmlsa5i/9H3ZAU8AXKUu9FB2l9xrqwsYRjSDBX6VDLryqJBvACz131Z9PKCyItcki6r0w8kVAG/TDNZjbfmvKM82474WQ8uj8ABnTX7dBsTB43ancPvHc2jl1YKEQWF6jlHaeBjzs9T8h63s7gT3w+OSx+5DarHRPiZgF4kLiWwcG7LPlcGsA7u31YxX4rus6XhJaAsf0mNvNvm6z0jjt1vhJxO08fV3rmM61cTTFaPrMyakR6rX30HMG6C3CjfGbrHyPgLI60CwYQsBXjxlv2HwVw2oYFntAxIxYbfBk21yBCTUWhQVE1io73vihB37ZIijfQ4KfjYU7ZmkptRxT8GxWKUJOGo8DKFIXCCggrqbKC18ArNJnZYR63Xyy2gdFZ4do7+N5tdhMk5VNgIsoih0O5O7DPkdHoP25yYY8I3POA2Gq0U8r5JkNRdPehMLHPtvqg4dBIs0VMGG9IvgRJFVC8sTS+2ryBHZBlvqk7ee2wwwtNs3XoWKnRKavaRujhdqrnJXPs9RitJT+vu3IzPES+WxHk8mAj9EQ9DMybJGIH6Mj/znWDvaOCJ2Ee12TCC2CMgQq3/KjAQjy9oE12UScHEUrQ9CkVVRky6oPRgCjGEpuE3+anmxd3wwrfdcfSxrUexcRtufUtUVsyJiX99hmMlR/ddFB1OVGwi18jURjMXow6RNHqIfQNeFS7ibdz6dJwJ/QADuJK9GvwHjNYbtqlNrM9b8uOZx1HYIQ3iJ/K/UwN8bpiL7aR3t767IdUGSmK1g+v13wfDjLZvBELhrGiEY3m8Ed8RgHnKguCA+Di9zudQQzoipfoZwm5dIpvrhHiBUviSkhKEEfiDo6rT1GrrtJvnwnEc9Z/BHem3WLYFFP1O+jhrg3wI9NGsYopotXDMT5nwPa+U2bMjE7g+eSUXdi2CC2hLZ5e0p9KfZLhmUcq1XQ/veAh8yJRtgzsXzv3jWNFuOGw714tbYo0P+CkAFUhhgNYrY8/YiIvN6nRXLRXS0D1eTUCqrYI2Mupy86ZeMoe5DXVlZyxosj3LoeU3a0wZGv5ZDx5P7ByICSNpUo5GAsZY8AjFB1yKmU5TQWf+5N73Mbl9q6XrW78OJ7k/MziY3Vycvnuu0ggsOMs3XwWUOXcp+lYDiyFLWUQzqTrpJYEvJnaKT853UEY5jQre4LT45OgaXJ1yfdRgKA7OvOmk6TCc1vEON41s4PaD7yM08utwi/v0kfczHTtymt6NvObS3drsn/Oo/sE46+gYo26c67LpFcCV6lubK1uJHgButGEEw6U0s5QAg9gKBhUdoE/CFIhSNVA8MNeiPcXz/9Y/QByJPGH3+gG4nfjNZ/W+pos1yFFb++WnR3GebLJH1qvtib+bT/XDnPcbawknDsBeblB+L9/3z/itpQjqyhjwv4yVsbFTnUZcbc4Lf1mxYqu1eWdRdWgdTOyFEhje+V/oMk43HG1XL9ZWT0UlVdgNw3yEGdXuB8ycipeFAmar4ZUdgwyZa2Bkmg/b5gZj+Otu0dqoJaKFI8vRiq7uIKConnttATjnClyNraJRg7WZBT9ekWFda4n9tnVA0dsjspnfmj8rmexFdqBI1XULC9SUTx8uJr90zpo+uNGcEmbFk+69lB++BjBt6G9gRDPyp7Wl9r66ilHLDcv5XXAMJbNeFjGUJESbk5Vcs5VZUyh78kjV0oBmaVK9WL/lw8N4svaq6irI9PrzVunMxIuU9Bo6eTIi5ynGWTJ/dMH1DRa3dySEX4CMOLGsyicwfu92Kds1IcmCSfgKCouV3AVjGXPiGmJRrpVip+Gm2MIpEVrEOmUJZ1t70wyA3nA3E7Y/oQsuKbSqPuPYv9CoqAGmSRHBEQXaqkcWxLlkI+7l+kPKyzgLVZcz9JC/wM9QxtK9bf/eHR811XNkD+bG2O2A6Wk+xflBUBLgnv6+Mlo1mOwmeCgxXR7lYIZt1+OEy22fvwngA5qzMQgdeFvuOpmm+qg6M/zfzEvVBJzi1Y86MY8yulbSlmxKvr1rkIROG8wGmtZx3ynOHpuKEeMBVDh2PaJV89eMeelWMR6chPjSko8JSGmVrPMnfbITYrQfmhCjWU5vpevkuZAjUNnpD4VhuyhbdDB0uQrGZi9TyEKcgzdn/VcvNw22qnmayyDHXBRdVdW0glJP0l4dWjqalbHlL0PKhhTzTyjFiEL9fozZUDeZacw3RJoSwrwmD2R/EbJJZKDX9hYPKuDT72hwlIT8j/AS34Ef97dw4s9rZ8ZpQs3v8k9zMagooLFtYAmtx4DQ7FcwE64zo0F46S0XMVpy/FgFTbcMofMSdDYdx9K21DijLVzTDF7u+cOQ/+B4ZfkvzAp0lVwVpMmJMFOWWnNXy5eo6XfXbMMU+qauFYc5FFepvdV9dIxUOctxwdnZ3O4T2DC0S23ycXFxgORK3rK5uXLuwbU2g6dpzmmDN80ARInT0FOpzCR37w1YwvEWPU8GHUPN6VVJ6ppfHBIq3LlpunxYdD9zZ/OJbsGTftV+hkKHt09lbwRQb0AUKfkcMRatSqBu/im2mpLxKmeyyJMgD9g0Rrh54lJnW/bKKwITubz4HgA7J4HuyUni/wrYxMnludObVpET43a7EGeDWr85wQ24xZLZtVBe3A8qtZW2it2NZnnCV8K+5W5f/6khyPYZuoXQwQ/zJsl8Lh7+JEuPtJA1BIDOrTH0m47ot2DBUfRax8nEwiSLW8nF8htjedOzz5Vm0yTN0GdzI268O0j/nZ6HkU9ZOPMsSyKslMT5VFRuZrN/kKWqERgFUWNaPv5Jy2cEt73EbaNf7rVfWSXwHBzQw2pUAXUD4TAWTEn97EBgvMAJ0FFrsoTVMf4hyU2UJ8UkqS0y8bo67pkcnhoEMRhBfTPYhjRCYnoLnZoSRaDmppbULXf/TLkiqxfLlh6VG+JmY4z0RmbRaDZNmcEayCvSE5ZwpKBirzHMvb64gRFOsDOeMKmoyOT9DGtSdS+VLIeOkoIoXaRH6zaVKgh4tu+XGHHII1DQUP1D9PZDL4sogfAvLqUqDwHFW1J9l8h/pFZ/r/yWhOtykLJLaoCC5AOzrvpVI+cIeLjWuFySnZlmOnE3aX7lVBX7q+3tGuuwCjHkRCugX9IKOx59dMkc702FoTbK2vArd7mHY5FOjo/cXM3c0HwBRive0/+RGZr9f0KdsNu/R2pctgIJ/rk4i+7bE7z/I/+jHycIK0MuqVdvOSNbiTgsnDtg5QSyiuMSXbo2TUpPhZ1M+w5jUXifUbC886d32BfZtPKneON1abyQWTrgmiOO5OsVQGVWfvGnHI2zWj5ZEmzwzGHpFyv6ezoIUOs85d7raOv42oyAttoaShFx3uOU/KRCZaYE0I0hBWhD2+FIUPejMRBGESMqNZ9Leu4TsQ0XUisDy5wsWFBndHwDgfjmCI6EiwH+/dFSDxoeeuNJm6efBAfqJzF9KNllrW3BTNx7GxRzdeoA8T4AG3WbE740PqGpjyHx2Fa0tT4GeSaoEKwryheNjJxMqntTC+kyT0BNMI5/scrIVoBIQW031GTbciy4rrjF5BWrcA+6BYiZMJQ3TgN4pvJw54JbkaMCIs56Nk5gu028VmFsUDvm3lHEhUVNBDTjrmDvYuO3V/hb28/D24CdOTjYhuvOVox2gY32bD0cySYi3/KhCXoMsUkeWocv1a+bgc7BAJM0SQtl5NLZ4fQpnjp2KJkT6dqGgSAPxCqnmk0g1QHyosKHNd7j37NhBX7ytQ3XQOOOX0KrunQoZiwX+l526SIOIUNBBRV0BVXXlu1g/KTUYjqGqjq9oGkOKmayCh29gx/nhb0tjT7IKS5tykUnYB28jPGWtW421od3irSlODR1bCtgejVJjLp05CuU6PG3F7qYr4bpYv5XJgAq9RpdOr4R/oSfOnE+QmOWkByq2qXgRJU/RYN135VvhqrSCf3pM28tWH5EjgGy0T+GjNoWwzVnoq+VwKsXFSPYqr7hCYe8G7YhR9L8C1f6wd0v+qy486jmoClFsRS1YAbFMboox1ztYl4jVIBZ+vZlJ+cuKhLCPpII4b82vjkj/Ocdecu+ZdGFEnRb0WE/wHWOjHxmuwLHrJyG9baZF5D0htaoVGOBTrxCtZO1wCmsu+wZOIEB/yYuFza1VyPrU2fKYd/rboPhvOQ5DbExin6eRxdL29suAZ3UyHNzZICHVAIwYrFmAAW6wSIZCrhD0eVsKg7AknV5mu+/5as6HzVNgx8nRSgQJSR5dI2v+cU1iKiFib7HhwV05/3q9Rt5fTXlbOpksR42ApUmxx9RfyjB/nBGGPiBBsdBz0jqxBWeufX2nzlt7w6KR2FZnXvd7BiPcTRjaoefXQhWIFkgibWfjtP2jWXG8O1Ii1JHyf5FVp9V5jMkZrNIttVFagfQ8Izsz6Y3GKFU0ygj9PEXEPkuNWCXTpOcYG3jrDEJDmGHkIp+/246wDBiDa7eV6ebzL38ngZv5zXDlWxOQ2XiNPoH/Et/YifegIF8jTywmqDHRpxuVHVg9IPkAxztdTOU+Ly5jGMsZjHE9BnXz3HCNN3vY54aon5Zoujk9mAU5j/Aru3bWD46FlDcnUdavDTI/iE/v+BZQdIA/+qpoe4buONJvApc7iBY9ANTGcTrpviOMVNpd5yHMBAU/IIE/KuUrrSn0sKlF7YRQ+EcO8N1UdCs1vuv5m9eCgT70SVMGQwagacwyJ+sG71On/dmhCC8MWFnou/9L/L9nsNT1UhUh1dJYR8IIofeQEvlMK6DeoEahY16uQ9YH73m9eSvwP+dNagt6Q+uIjP+fBZrKZ1qjlyvAtTe01eO4oe8/41+tMDDU2eu0N43xJp+qxWm2FelTTcEzlcqkLQb0Nznytquvpe0BqHFBiT5Q6jv1veJDUopnKvrreYSYYkPDBTdiNRc9HrSKlvL2NJ6tJ69GqTqcSr/C4WPlW76zNvSWpaaXwzmmOfWikVm62jutKIH/5kKd8mLKTnrnpmUif/LeHC2rGnImtOi2Cwio1oL1i+4ahBG3DxO72FGerSd2/j3j8p1rKbZHiOU8i+018nRR40LE23ynbYcnrK2Lb8V5PtJMwvYAng4o2KJC5Ih2QtZvZdTj9nZaWv/324G5WpA67Hc0S3iSfo+WUwjvmFz0Z3rwFov07LsuI09ZFpVLZlPvhdz68FUhaWEPN4KbdJpXPiqFcoEKqG7NVeW0nqWzacmrdVNHpOjGZBLvMIEGZdDLSPQQLtC3IH02DncB33tyQG/O15z0Xy2CCwDR/Dq7gkh6A2DC0OA53KxZmxQXKXOAGnnLFZNWXkxeVlJH8JmoKtlXlcrqH2yL4aY11i78Msls6zKvgcVXv2BeOgsaZiTL/kBuuoWBD4C6gwPJBazWVs2vaCaaaj3/JiUD11JMR44Q6gKHBw6h79ZjOthCJDTtaursCNW+oOOQj71COcBBQWERO/i0LbNNReahr4LR5pvAL78VgmnM5WL2N34VcyyWPeKedpxBByjZFVodJV86iWT5MsWn8H/INx1m+J88agYTm975JizBmVY3/jrBI8ixiW0qHa6T2BPgXXQRw9A3e5aP1Ryiiq9x2RZkBLTXrmrro35F/tnLBI7PdvC1KIAFMGcou64AlpslQU8YHveF8wEZkA/Z6qwu5aQUUmVVQBfQ/jR2kWzz43KQiAIcTbdXwsVuybJVNYW6AXV94rUW1Zf+Or26P2JHiPCESl3IIThmYaTuZae1Cd46eyQcm8RlSeRbEvIIyk15uJBdlVueREPZwifR9RCNHT/DdeJoIO/PVCkwLAOSM30JfSFbM+Prihib2m640olUvGcSotAagHPuadYFPHgXNw0U03rih5WqrwKFWVF/Y/B536CFVefZ51rhtNuwDkNTN7msF3rqPYwCmOdgCyzCKbYYIf7+fIPZGmtwrNjiLQOH8ig40UhZ9IwpV2AalEmEwrYBFpw20bO33iWREeaRH05EMnsbUrV98iOd0yepwTgySA+SCYuxQNJyr20WnHqPmk2+Avai8YUrNxeVBuxYDyBmFgd+yxC/HXsNh7wR2rg89G+wXO6/dwu4ETjNU72vHFNCRorI+6vizeI2CTkd5THuybbZVFZ5di0oUQTddfK3H0QFXVjkd2nRjW7O5O1Xpi4tRawWdU6igod4MjvP0LJoGrxF8zGafWxFCC0U3aMw1i8mZ5amYm5H1bs25ojUqIfqoSGAX4B56mWWV4Nq/qxV1TzzjzupHhYdegbXG9/n5lvy9YMaBewkiDxEjvumBMAxNL6wP9aL7Ie1nblZ1ZRohAyW//Y7pt5x7JC8UVa16LL9gF0NA/6rVPhmkLsxjd3ygofcrUjD5a3BDQGyWX3wzH6p4t76HYp41Fcj7sfO+edjAI/WezQbElkl0Om7Hv8IwIW0cL9N79G18YyifipdpiHJ1VLadOlpwITGhBWRJVKcucPoDxQ/hR8crtab6IB7WMLanlv98KsSVntsbHDhgmNdUA6ckDkabMKBIR04pnSBrcI66ZVP3o5z72XPsjK1QRceMV5CRX1tY3ycjN+s3F/mvTXh1q4GgS6i13M6I8skx5RwtqTmHU9iRJgkNBeaaJJu1JT4tMIH6xWPNONWw2J4fTV5jbJBAp4Q41sHXjAh7zzFqdqOedQyq34RKdCuHL7GsdGmUANIhZNZEgTWzF/YH5w0KzNm76N2JC/0l5CdkULR567lCuwPNVnq5gwZfygq3Xbdn6SrguU7kaSL7Y606SjYtHN6LVbXjyucieW9K8HaKuMclvEQXeXN/ho8HxUR1XXWp4/ZSVHPCT4myUgQCwalmvROAq2NfOtHVj9XOAroijL2+dYw0IJgVuHGxLMTcNIg/zQCX5qb5a14nhoi9e22UclxaH1pOq0mN5tg5r4qO1UULrf/rRDVypk+6258lY9G0+h0DN2TB3RbTdSpSxVfq5GUYJBD8VU+9Qi2k3WaKBXH7pFQb3yC806PsGKClt9TrhiBpPfbaIX+OQ8igaYCRn30RFT2xsEUhCP9yE5JqPc4mEN0+d7NdbQIMwqi5CqMhN1j9b1yW6nsiLvTFhBu8LNexpDaTwnOYkb3bfPD2uF0oEm1MDRy/WswNo+COgWTvpcZbxj09t7Jkf3A6rdbFYr7Huo8rkrcJuRTv4NsdFJHBxC4DzLbYibim/wZsNHpwdXzQ1tSUU+C4zK008916z+GYDW/K10ZUhNRqXbmpa2r5MhFzEFy6vo/RU0b5CtAI1oKwD6CB8JlOKIZwyxgwQ+ZdbFXAG4EIqpmEO6GMZuF7kqW2P0OzmiPkv+R64kB14ktYzf4lQ/E4Fn83zFNLtksRWUhWXs/SZm+0ivFhp3HNEOCdvGlq1SJqvc02GfZZWW6nOpRoXZGM6CCL+RY2PjinCV5tPyMPF0X1+otiyBuCxJkmixf78B/0G1/BqMQfS5cdBUE2NpL1Y9nkbpwXAmWXaiSF1k5ZrMhWCkTkqrY+x18JgqRCu580Duj+xIrMV2N1vN/9Ok4N8Piiv2mCj9Ns09Ue71t+11LL0GdiPOEL1UfjUmyLnpl/hD7AXkC3za76CvHozSv9GzN+kOFYTLsLSG6Z7RF1xZSXWMO8mekZ8LR4LpaxW643BqGB6MQ5rTf/hO6nhwmHYdigiUnhGpH6fqhEKSP2H8DB4VqpnyeRh/J2eoCh9OkXun8f/S4AoN2BMuiGy0ltbMDVTKj5SzmUG3wXu6ieFrQ4HTmkE7O0lD/ZSvEhB5dmC99XeL6RtgWno2i9kV4YXVVYoCNnp/fxaOLADH1sRmj/FOMRIGTCKWuaV9kHAQ0DJRFmpzi+a+3079U0U+UY5fqF5ng7pLWsY71BjCWEftyQTr/ALLDBNvSfx1ngrq7UiS5Sbc17e+WZ9pLtYTIhiE837PtdSitpbGTtcbfLGWwp/anHbgdV6wttlwEbpKjPup5/Oz1h/Yk92o+lghn2LYGNfMQ/BNY7JUNYmhEno/VYNLyj6z6G3SSERdvbnjw3dcH2AA/82ln8vNptQMcYJCpyW16z6tj4fdAWEsFiyj9LpT1eRjf04KHGYP+5pDqi/QEnlMK7l5uTCLONSZ6E3iWUWycJhMovYMPisWVafnQUzh/UvT8L1ljLtpWhyicE0t9EqLr6srP+WpksM4/0rtyYqejmjRUFT7poupIKmcNFTwtjxZUPjn6D78mSVrp6Zkq9kVNjAzSmfjpZYxDHW/mCiSdkBqLeH//vuKMwdu6nZZYGbEIKbxxYpTT2Dnj7ViHFEc9wywjOL5ZFl563hFYUdwmrIJ79M3cu4ZMWECLOxG81OEse0W+uz8VtA0cxXhk1ZCPSQNYxxUqLnvMjiCKNqxmBwrZIJybwYNA9oWLqDC/O43nFfHAF9LU8YmLs7DkZtO6Vr8HwY0mVV3R8mebVuGlcUbnBpOdvM0Np23inZQWEeRlCFLpEldmIzI5NhrX4G/OOhNG+JNtvXVIDsZ3I04rufEUCfG87wjLpC+H/dt/vAm/NzV/S+ofZy4uJfgxTABEjXfCmp6Td+JAk41PdMf3AWtc3u/+ZGS5srb+SL/HXAbhhVlPnzUvG8QH8qYHpHLzuL5JDDJ3jLVdd4VWogCFTMis3QSKT6pPjSCl3xytMv2Hk7DNkSQxJul/5BqBKXzILDGCN2m3lnDeoW7MkXtTYVjKC5wFTIfjalTKDtc/87aBWplUNWuWZoKNqZqFz5pFZO3fQPbs0Byk5swiUl68kze0TDIkS4eh5IHC0eDuyM69kp/2+14tpSN+3r8I8EckWK1OQK/bT6wZ1m2GQjWy15t0hcHAZrE38AkrDwusPiloegni8Oa+V356C4J40WmS7eBo17GRiCoxzUDVUSHdxFxc2m+wd0ohJbjJaY9b2WuqzckzSETpCrTXozHLMK/QlCDwfhyORDhsWyX/Z/ajFdUfBPxAMikhc2j+lzOs7nsjI8XKn4gODYObcDahhnS/kmP4JBH6Mu7II8hY6bRbbYRrhV4gnoIvwQt7mFGkmydoScJrlka3Xx6DjpcdN3vmwcgjo0HSV8yAt5spcu0HjrQvibYgDtv5Oha1tjI6PqzeNsZAb1A040NOeA22CTNwMyXWWZLYiwS2MpL+dMtLexBjCe9+GlKFrsGhSEW8t8MQGcLsUiXCil0czg9uUvbGC9AQHgeSiF+KpyegZ4mlZhhN7ubJi+m4ngQQRMKl1t1IQXOL4n3cis23eRu086kU7x/9olBXiY/a68CFc921szZmA8IxpBFFSi6DkUajqgi/Cpy89S+UN3oy8vVEtrR0PcAd0bDui5ONIgPS5JKdFWnMrTWCJVjVpEc+MREFM3qauvQdf/REHGAl9VPCOR7AmQsL4qOrDYHAyS6Nksru8AW5Rn0Kv6shCSgLpsbfGpT8DoZKva8n94MHkPTWFZagEgSp8YdoPxmBWDZaFZ8W2/HYFYYRK3uOOgiDCO4HBccHvOaCPrzaqZNGgTbKsWeKkW/r1Dy6QlC8h2VpjVMgIW1leFEUqym/nH1PdnG0cr7URaIA16iaF1hSQolNfCRYoaskacX4NRRnGl1FUOk/6qsehYMfsl3/hPfB3YL3AbUVEqpZC9DA2VOkQ7JBsEeufEsWPGozlSg3pRY0Yc83XE/tn1fEAS+wxtiyaF3H329Snm//+gGMuu+bQvlvNGJgZw3ioem3HAWajRNSmW6HGUHJZ6pn06xcYDljPMGJHCfb2inq3SS1C1MwzXYH01s/qOED8eFJW0b/Ecolps/hbYSGbKZOq3BDSV23RMp5fbocRljuk8E72Exe6ius4Qg1xIV/4Tme3RP4HRS3GqB4ZL3qR+2Xx9HosThKUHmjdkK5yhh4E85VWCxjTDwnYMCfbnypX1CevD2uMsD8I1Mq0l7kffu0L1j5yqGHu1YwBsgbm5YX8ajYKt95BRspxicMz0+ufDsxS2Wx+9WJQd7nbBdk3VbFBoVlB/rvj5lQ5gM44V6Vh9/ZkE3OcdJrHqgakKLyQW6eUW/JdTIQl2BZb4M5ztRRoYFewfJpapB09btfuig5JVe7YYYIHBaV7tqBrP45arYSgey5uztigKFjrvzQJzmXGGjFBymTeIThaTpxWvpP7gjLkGkzAGBBj1uT5QWrSI+MTKpXUmPbXPkhtNsWfMc5jt0pZBcqQRCVeALglpdAHqKMHGjYhQnHhT57yRIn8Xxws52OKH79A+8YKNXEcOkkonKTgrDZHOkHVw3rYW6WjObFTX4q0g0CK183yyM30DSfKD00d0Rru9h7om8B2HsYoUR+jYN/vMZAvxfD0onybDhZaIW7GU3t7i/UIilnvC8lEV2KEgCdtdWo3QJJyvOkd+JWMLjn0ybHfknpmmqqDUbpKtHyTKwydZzKoMUPAVqKL21o+Iotmw+bB6DmjBu9hF0Uk8yj1lqsVB1ndBWg7XrHd2wqw6GKADtzBDiLBsoXHe40x6rCMBFcpMohWEGtthPfzg9t2apEPcHuxZ2LKNn7FaZpPuraTnVV9gKMvlj3x4zlSZqxdXKWyqLcZwS3gWEy78428ZLoRzFA7NYiv3VkohMUWqnEZ0DsT+lxtCSudBqCYLl+uqjTXvglmYTMU1Kw8mQfdNJuMoRWD+ZmoPMGWEydaYVAIn6/p1pduhqdoSr9I2M6B9julIaB2bEe5EY1EIJkHl3zn3JTl7kePBLzCmAFV8Fl5t3gowFqz7MI1eKBPRk1lLzBHcvyKtr2nDZkJeAkrDREgmF34ws3ka6563hAw3BBKyaxWjG35ME7FSQLgWloFilkVeT9j7TrNLj9v2r6XTQYMcWp9HqkxMKA+/Ogpt7ypz8LozVmAzP8QTuU5DoI+F5DXzMnNarVld3OgAPMjvCn/mI7Et24ZyO3hZLWq8Ie6RCsC0qeTAYGw+/33PCBaoaXZ1G9hPVc1g7ANMBMgUwx9qhYuLyDbg8vtVNOQIW1r5PODUZNeF0Lq7zxEUu9oqFCsnQaL0WHgfxieqA+lqzCE+cl8mApoZX5BXMVv7fGkXWPwTvGa3QFpjG2yGrExzSC1CcVCVYttZyjnBptt6AmsInZyi6JpIP4NMtAkYijlCXZ7LubcNOUFNHlpNX5emJksoToyx1f5pc9tnQ9EuBCVqrP+GvFDiarWcbxRSCJ55926YJiXI5Ia5Ork5NO/PvAszfhYAjP0rJZBBjnM15SqTrBIdeou/WaIjiNxCvV2Fz3eula9+CP1D5S0y1bLHjMFUxcKoRYcxZCauZIkbXuuSwNikJi5UZcGfBDsERjm7xaw3XtpRJLEBn35V1VplVgDsLLCqsxl6+WNbjnjmUiIUzVTwabrPBVoVOJJ4uYWAYUH82oHKEMqeLu/WVBg1mzFL4WOg4RllEUjYw/HFIv45uIY9ZrOFtMADbDpcMfSNIVpc5faWzydWS8RNoC01qXiRu6gL8zLc/29HuLlhSwdDL1MX755SirbRznpoNcbhJknIzYVKguqWK2HKfl6Eoe6PWEfgNYXyv4k6tQwPE8HNo89lERlF8+9CheUFUSMM8mhYdYu9F+C3pTdVD2IonqDXKgh21H2NsX3zeI+gGIMP8fKcaWNwYuBKxhIFRl9JcGZFNvMgwh0Qot652WJ/fRSSgAkrlBmVHknZTa92rwJkq4Qo7s9NqRJAYsGZPP+Zp9AK+VUwpJLDVSpcB3Wqx6sDzAHlGeMlZXre/JCHLL0dHTdzZkEerj3mEZYi19WXgeet4r/hY4TIYcbEIVBRJDG5IUiPBXW/4kHmjRZ2AGrejSWOxHYh27c1JjnpqSQ9s5GpvPMPwilPL1Q+DKD9q1fDqDOsR0vS3zZcuLbRADCSNOtjioNVLpbe+u+hfrF342KooZr2/LgcS6Ar6tDwl3toVDSjtfu2e1zaxMdg0nYpuo8JF2kWf91ZCr5YVij6RuIplwsoQhA6IkdC+qYToI8bsFDckbsvTyM+LrdsTeC9gKydHGB/aRyuzHhGdAVlJbL8tvA7zAQzqP4w/5bc/oqqclHYUnxiGh/j6SIB9kRV7+CLRSKBW2sZJBIyCTrB/+SCdl/PVanapYlpAG3h/2pxPukfh1Ta068sdvttkW8tfZ0OB1Uyu2zBeug+6m+UWBcWINSyAQaJddi9C8/It80e0vWFYe30mSPj6erDHik7F/WWfyQ85GYaFfmM+Hz536txA85aDNzOYYT4ScahuFq35NdYmMDv9KOSf6I2fac/oWTOEVKz3U3zVWrqlI/ne2B1y2P0HxoE6Ycydhp0NoQlP+nhZ5Y1ZJ6opJrmclqLz0KvZPi2z6o8vA2987V2zxnvej5Pmq3PQQjx1tir4pSfgiwqYTPO9TOS3Nh5XMWnkWLje/cjBPh55oli2t/0Le+Hkagr6Cd+wXuOn9TJBeMrUT64+E+PGJgJyy0CIq5FV+X9sPZhWlRpap8FQ69VFjL8EROemG+82R2C/kxwIG3Cnddh/6zACnoJJKnRseIyQeh5uPHtxwMuG/Hm5nuj2F0lnZwsHibSun7O3Hyu+Mj3y7ceY7FEhj+Qrd2i+vXJDpu6rIs2tlg9XZQSGyACsdS+XKQXLpCi2a82s/uPl+MKHxSZIaC7noszsqKaGC2Sv9wMs9WvAUl89ET6vt/uYvltgcfuNN6eL0jRGTRjHltM4JyQoZYNjTmkI7ndHPUXkwAHSCp5HAaUqhqOQUJE7M3OaJQKS+aomxRxGL6vHCs4C8LyfnGZ7VzuW7qeHEjtqwkCn2dTEPhjn2UINCUBDat0i36gQ8McBX7xStdNxHTqIZ+Va9kZIkvfMil9D/UgECKHn1MvcH9CLfjE2K1Ztu7VLrlBj9llUnZWywp8bDivZL3J4rUcMCQnc+EmC8DgP+mxafX+KxF3bXHxsv1+5leFsk5ivgWHCUNiXXzvZ6oJ3LfRennBpjpvf8T6sIH8CyC8KBxVumkPCf8bPRTxqA5rk/btsKLBdXGt3V04b67EO4eM0PgqCVtmgi48LxKAE827FXci4IIfS01yz0LHeW93qQVVqqgyo8GcEXuD3ftcSJFW1v+cfzeA2EFA34bxlY+oCEviJ9JjJINm1SU4jrR/5YsX3Z65uNWjgdp/mSXeEyyAteipMf3TuqsNEikAAFTDhjeflIOsL45LPTDzpaGBJmZKp55wI1Wcpc5ScdT8uq8EoStLufaSSTOUXKg0N1ueOOlavn4Ap84P8WYrFKyPy4CjK8U0U8h5rYRQu6RJmpDx/fufLFoD28hOtt6PxCmyke22h6QzPjqVUO958ZeYrNRLAFPCZ+9KU7w3S2hqwBjKPK1Z1Mu8otxPMz28GWvq4b5dT7bxq0IG+knnxcycIMbiY4cLnKaICTAimEnm5KITufcXFwkOez2MOLsIPs0fR5C0QqgbnJa7VVO0w+0aD+nYi2Fa9xBWrMDC6+tSZlQDTmdyY0+4Rrih6k/JFqFEASCt/2Y4iYLJ8CnVPlrvRRY3CeT3jTg0jxwtW99d0ifJveoP3pW8ZoszvatpoSAXqeJNcpI6We2Y168HGmrhLEmIQITUNFWw/BKZt6A5lEUvmeWsVzrfPu4d+Ui1wNUJ7q9sd4f4q39+QcQzVV84/EtcGTfNlK5+4FRTeaF/JyYVZSEQqFPDJ8RJR9/XAPbDcJTg5ztIFcCJrtb55qZ2rqIbaCQCRjGwlGOM3sLGyJ1cxHqqoshlQ3Q+lwGMZI5hM0Wp0J36YaTwGAyNQtaE1Pv8AdzNW2xjzmKq3SE1mUjhoL86xsGDYuMCGoATkrpk6qJe1hkbbjRPe/unDnE9Xed4ktjLVO795ZyjC5svLfSiEbjOqoEbWDnaJLID7aXoZ6Q49ybLIPxsvK/0ECUvwLXNyeOLBqQsK44HQK1iFpiXbVW3849BHzNjS/hbUiI/eLYLfk4Eiy43EcsQPm3KF59zxkxsmcnnyaP0IhJiMPTfOUGXb79Hp9hvA9PPaIIB2F3y2ve6qZOhoDtzCVqZmF+DvptSo+DXBqeGCSZCqOcYP16OSA+L7JOD2w/ci6+5htuaSS/f4JM9lx99cEZ+/PZI/2tvegOE9gjaIiZ7j7OO+vevHQRyAknePIRlfcpoyMz0yqqSf9Bcr+sISfeD0EmAJxxZogP/YKUPTgmBl+fbE4XEVouR3z1noHd28whF6UkzltNprAzKtA82OK8bVL/0kYM2ggerVkz1Nc+G70H9Td5FDb8cHl0GVpnUNr401yeu1kCnrFgdjmEzxXEb3AwVYPXhUVtS4k6WjDOSZpMbH3X/AqLPSnVYdEGScvI9mptMzYf1D+UoIA9zztFDd0nh4Kd5Tag00OPbyVTERraOUKZPeBUoVd2a+kfBiKneo8LjWepiilzq6XoP5jPd9SS6svLzMAaRU6xcdezf/WP0IF6IVYMWCxV1ROfEGOU8HJlJ+6Q5G+EvvinuFHwevAZAj8Wj2D9iupNW82Zq3Vp09eejLpLwgb6f9BtTI+y+3Nw4lr3dyD6BYKMu+5s9G0aESF1mc47p4L/9tvoGlMmzt/zjRDtCpGKYIoDFf65asLnNBrLh5A98PLD2HI6vUyRwX1FaSzAoyHd+3/+bbp/9J69N7JPKmbk9i6HNrPyLPVoMLyBTX+O26sWryRB+se3CrAesKi3aPnFinFDDIUOfUKxTdJhRG1o2pjm03ozRRK4K2gwu6hrMqkmQWvkj9sSxWrJEZ7Qb5Rcpacg+ZHo/Hfha5cXzS4Gp4zEgjXNnxGebX1aavoL1/xEEPK9rxRYaTwLpllIF5BHBbBUTfQR3m8Ea/c9TQPYceAVrlVu1AcExhXvJqWPowncnKw8MD7GH+8/3ilNEF69Sbcu/nTpTskS9k205Z7roHcPX3bt7C5T9kb4a2dCOwF9LOsc8n7QR8xPIfXyypoSfSEYpuxgAm9dJpNnwqxEvY5TvYrsJZZrumg7jsGthIfZwlIwY6RgvX8uARtPC8VzzVdp6Ynaczc2AGji03Lb1Sg4Z29QUeDmElPO6wCZQgoBisGptOpfuPreFOopRA12LFXXY9z/Ni4p3OizoWcJfv/Jnb+ycYLNYkIXMp28agqL9knQCXT+MX4/Blnv4/3Svq05puqGVGTxjfww+i78M8tNaDXafdJES8xfgVsoh6dEIrEcciwJXKyij8KhbnuJi08EKs+2q1R4C5JeRpEmxXOh10kJgwnAq7OOJqKy7mAAz/03B76HaTeihXfl+J792wU2ZKRpwKZPDlVnerAMfAhG5qcG6C88IAW1sb094WXdwZroyiBk/XpxtfgZQFh2r1x68atbAX4Zl5dGnNVW76YMCrO5hQAWHT0oMO/es4dk+HGn+uzPqZQtBoeF2otWL7orivUBWfsdc36gIVqdnavopcdKbpZAT7oPrewoTjXY9MgVD0JzFpU+urXgm+28+cDO+OUyMnyLUFOgH+iwCVm2q72n5I4VKEAc+NdT/g2L0RjU0H8aQlOhIN/G36Fmt15T5pq8NYlpd/jUe0AkF6acx6VJIwI7yEExGdSocAqPo3aaOkgwoxVgDjC/OKzbD/I1NUb6l6FmitZE7t5yHleB1Mp4JuFQz740OtgBnGU4CCsOQl88xcfLMEHyN+Yta9A3VgPq87R6XyQrN4VsVGdpIMc3vMXb1mJUkUUgBugzz9/myS6qH7/rqYJRXHfAz3uqgKGLgJEt2ywA69noqzhpxliDVubUhA++y1HEdR/KwQxuWUwC+/jEt/EIKmd3dFcIeQH/CKoat21hOg6Br/wWj1EgfCaQ0ERSI98NbiXbuLfGrLGe/1/WGiLvbVzwllnOuwf+Qi1FF4/uAQpstirHpciVZMG8hBuw8dOGAMRminNWGaTtRq+1M0FnyknqjzUoUmZEaS43AuA1sj2TAfObK+nbEIVxtRkmlFJ7qkI+YP6BMtfWet9gHxuCy1UpQZSRh8dmEN9WosDWHQrStBDjcDjpk2YR7S8bktVbD3fdlvHZav82y7spP8eCs8mxrPOA+phYHq931GT9fFPf4FnHxGh3dPBdcwmiqUyxpjkEC0nrkfH5rksJgKVrAvaQMqPipkr143vU3namoT7vBVrAAdSeBTL5MfFU4B+GWEbrrgO/TrgyZbiflrHdkZk3s2whCqzBZn0uvrPcQPshk4o6qWHI70WvRX7suXBhhsDrmtZnNJVYO++3Pz3I8HQO5+I0YZw0GDJ5pj3JG9vYFdbJjwSp0FWaXtgr1fAjmIGc9pMmcdyLTodtRDuEo2umHISSK0ske8tKpTEJgDpm5G61fvDBUzCQFGmx7V/QoCfFfACUqX6ZSqg+G05FX29qtOOH1aUVHeqeuZGoaVb1MKIFRrJ0ZUiPjj4wSYZsnKHw5p7uYYgmLA38s210lIRQAxST5EMOk6fl+gqrsBMrQesigeM3cAqnJRYNtx9m5lq1NJqMZeToETC5dIQ579/+9wZTvaDwPOTgiU8EPesk2M2qR74tfWVoSCGyNPdg/Zu85Q6W+2d6/1I4OxNoXOH/QfNbVFtLzmGOqzh5hITi83zd2O2bgGnSZFJMUvGMquF2SUyYWIPimTH62y+V39AoEi1ccyZnkEHyPeTK+29XV6bRwOmP2MW2dhhgaxRh1VwZaLhvIetTOeuOTiwtV0A7mdkE/u2mBCYtPaJEreH23y9a0tx0mJxmclbGyB9EutUQmIaJQLDmW0b+KYEgqwb5agVaIWJdxqDE6OQgwYCcpUkFwTBoEgL9YdtDqG3gdGvv4N9K4URbd0RqR9CBNtcEWQjS1juG9w7nstl+yWQpIZt0pa/E0R3uC+jzH6WTraCtjVH55ILrF3YXjhQnsuWLh2/NItZdCGPWf8HdOet7Yqkc3BxjexutD/8Qd+cEFmsvrN71M3qj+4SIEY5NLMv2f0UPaeFtEL26XBEDjbZmygHalqkGm5Vi1GFoTwfnYQ4rjaTzRMFUzrX4AJaD2rpEhHGUZ7e5+Z/IcloXxN3upTFxITrae27KjdEQNI2N75YfI0i/l2cNN/XwDjbPa5NndnoCeRI1Q3KEHbhC7VL8Fi1vcu4wGymhlGCXLrwIjOYHfznWuLT0aXByMF6T9Ga4hE27UvZ88MaHqzu69nsOa/wmggsfVAm6JDazaagpztq3E34VfxHS4GPbwCZuT3cOJow+Q2mhTMJGVXsaw98kYN3CKEACwy1aQk3hT34/imAVzskKhmIpMNJ195SfacFZTozeN7Tx73Bhb/8N6D6h5eP4iN2pSqGdgWWmacpsvDDK0h30bPMrBUvEc0XzzThiYfAHoXxumhK7B0xroIGpLb/ftcHVlwpOyC4ctYOTn11Lbsbm23fW1hZmQU5du3PnWWNfiYEXiBD7tqLIUSDA4tCETnBXsDdFmZ5nEnOc3nv37rAZRaW1hWOtiuThVToeECD4stJ5ihaa4yDePNYCxvGGuem1lbLseitSI4zPZt5iP0ux+ePNcnbawdZiUUPDwPG50KRQVMvvmP8GrUm9rwkNtNFUs2l3SZaWdJNogmXuC4fVlCoH0JGiCUgecgeb3OaYPwfrnkbEfRWI6L3nwGPVgcW+BXf4Prxcy5x/EandmUHU63kRhsp8EXqUZyTm14Zk9NxLWHeGeR8cp4UxFHyfNfhtsphSeT75klteJaCI8Oc99oOWCRnRw5ZifBKAo0VvIZpa5YDvppcQC4cmLaO/UA6zQ7+F4gw7cJZQslq/ZSNpNvsNlVQk+dFZsZFIm8t0NKtLuKd0WpzQGVEr3tSS4tHupgroFAXHSowISOCz+y2DtzSZiRfQtIh8MJB0WEJ+ZlUuHndPC6rVj0R+WZsV+fXWxLMeA1arnu4mTs9op0Pm9Ip6iWuJ1TLRagbKfXaWlqL8Vh4oCrnK+AvChqO+x9OL5/e2dOfvLkvyPnVsrTQMM6Lqw1mresv/oWy1Hsx6USAm2PZUXRLLvk1/K56DRSg4Zkni08546IGVVQKZbR1qc2evWySQYH9S1KBji8rD+6jc7QUqMzXNrAIXIpiqXshUAFuqNFPj4M5n7UWV7X3mzcLc7gxTYK+uG44LD2I4jOUN+fTc7higze7ItYFiEz602VJYLpdw+W/Sv8/cgmFdO1Y1YdhIyAkyz5VhKBY0SDjoGuTTjbbNobXr8xQEUoXxA86rAUL+RSMwnEFaX9e+lOPL9Po14LbTsibJuBLmGpF/E3OxxbAyV8ajtgx6dyf/O1IhIfTrDj27IkOM+GqTHnG5zlISc1DKRCOOYEl5iLNYnwR1SS1Jj8J8ik3UpjQrqVCj4WPlcnQYceaxBa7YLmoAymgCNaZpqrGXiKf7saC1OMq8PzQLOr2cF9qTNY8988yAQtwfhnzrXTNe1Mlk1+0IRIaXgeCIDTVyE1Av0ri/87OpPwGYTwlTIZ+oQx8jT6KuDMVUq1sAbnaIkj0wUsjv+Yux65dAzArWdbmvRQsiD9/fWNFTbMJTOADccsmzmMZESkKiNFjvW/ZjBVFucrnhZFLQokwflsrnBRM4ny++NGUwoe2UkrqhHjYTfsJpv8KYMUKC4RpnDMu7jB6pnQ+u4EngsGgOvGpUJBj2XqdFNVFaZYCevCq0HoKMqDgtWOHTGSzsCePhTwTRzTiH6pCDpLDXVxfCYlnM9qsvTDIitD7dakRuWvaRJs1XMt/8OLYInMLO7PQSGOqi2nUaItYQqHql+wONwn35bqzb6euGasEiZjYhCLQ3M/xtvqSTUBr2hcK9QWlfA0+1grpFK7iQGdkyAHXJ/nHpgU8xIxeOxeDwBakaxf439SspjEYZxwA+PAEI1x9TgvRCdcsgwwlnNjfO65I9TFuI+tvUx8mMoweEVOIh/73kOfeilOkx0U9JDhFZ8UPUlmTePBAKojXi8yUesqlnR2fSW0P57XZoikipenRVGfh/pI5qDa2uD/k01qk3Ct65YjpSXSao4ICX+gaUZfVImljRijhqMkS0zOIjsUsLu5DTOMFOiBPhsIazgAL33qxZ+sr2MzDFVmqFifU89C/Hx645rSLxhrnMOWUAC6xWM/npacv5IVAqZTuGW3Q9BDPEh7H3Bh44nv3FmOEFjfdDYYsDFwiwE3OYq3m0LhaKQ+I/isIbdNMlhyJEmAeFHlfXf9rQph/eBiyhfvSH+UYzz/wpjzK/3C5JMn4kbCYTMtt2HzreXVihcdDzz+DKWZGKV46OHcmgIUTMrzyIPJgP46AjQaeWPKpPfTBzhlJzhjEmsSyEhLqI9v3bBmcyGogQOdvWSWwbUsC00sJ15pfqQeS4X02l23xnyXsldCcY24h7AkJAlMZKaCDV1aRaJltayVeGIi4h3MZV4F5RYdxyt5nKOEm35V6YC42OgaolxVLbId2ZH/EF04nBqHicbR6v2pgoqPun+dKVADZsyxV+V5GDYpWPBxo0AxhFrlLnkC7wGVh+PQfsimg9C76RKYu7LyqCC9/ppM1F/SBfU9YzRVBw0eacNkGrihdwCsi3fS/nUYWrWcgTojuaL3SYWH0qu3GPAp0vwOJc8Q3UiiaKLIYWFfo0ZbDY/hyfPSt6levlMEfZP9bgPNgkhOoRBSTrIa9P8wmSvjLMG3mm+xkyo8UOxC1HfwoCuEDbMs6GjxTfqJrYCK7sXfpIKzLYHTKNvfj/PpUqXhbPs6annKHXF7dgmaVBuEHY8Qc7RDYU43oOQmwvTTd6XNWyd29yM6tjqqRMf8ZMqptpGbDRyvOuW9t1LhlT9iE0hLpffIoUkr+xO7yKGn+Yx7e9d+Gp/7F7JOx5pgohNF8GEcIW5vh15ntleU0ggLkGlNOz/B+1lg9vaT3mHCgP5TSwtpgMHsWdzbo0p4zu1t28F6SVAXDq0c6CVAxLkTeNz6mbG79OIxDWMJ/VrkjDQ/f3qUDmZyASOGzmf0yqQYUfcoTleF7gYhC8UT/0+T4+ED1vzJ1vKDh4EHXbrJg6IjH+4KwbKEUDY7gcCvi1QHUjaiNr3rpWjN5e0x8/TZ9oQapuVOPVUE/1vGg/OwjFJvV03OGtbuW3RjAKct5c1yycCJwRcgAiThF1H5ixsdAUpofjthnbIFKGjfewNMRd00bOephMlgIX0xWfPQBno2aX0vKocwB3/1Vd0Xm6YHqAxPP7uHbvVPN2YpGzpT9ttt8+vTkGHcvbMG9DZVwuxkrCokeO6NlPeoDfj+nDgFht1D+ZYetanpBkXD8KYGFidRUnfiMqlj7ioc16qmUdEZE6zARLF73NyN+y6ikXou2sTIcAcXeZ1TL5dnswpUvf4aprr42FUtFtw+5r6+UlH4CdsPv8AvurDFNLFuBJ87oAOHw3GWs0TNx6klyWQXK7wHzfnCuop9HXDPEZ/wc5mdOSIrmfZx2fyGutf8AIh/uX5mUeP35wkzkgD/3yIetjcIOnX2mpB1K6LsfBha73SpUuBNb5V7icWjk7pz+DXqc6Zjt3eQfLtOWVmUc1Yz379ZSdBZKyGG9WJOcEefTSFwI1o/F6ZSA6Cl7Oj1TWjWdTMk+4IbFzQyStttmBf5W161IDgpfNFJnmw65O/Z4nE7wJRAYw+C7jU3JT7Gq82VwiSpDhugdY5ea2q2Ki1Uv1GKhdpuJcHFWj4tWjDqeBzkVMwUquv/VaRjmdjC6qyGoqGJExeNWt46yB82mueiHE41O8QHBwSRDURikdaKlH1Ck+B7Hc7EZUYKRyaHoXKDNGcQipE9+Qvei0XEH2h5IInvyoF2Vub2FC+fStDlZMBK0F7tGuJ+Zvfu+Lh8HHpehOfsbhzxLbHWHv6Cppz2WpMub058fEIYaHy8Up/O8m0tXMwv9O76s8yS6rpXRZvUNw04jqzhgpXa7WZrRHsZM26213v8CcezaOaqJddV17DoN9jj/Uzp862cW+bBbH1/1gwP42KJHKNdW2ee6Zl1bditYa645+YeiuVrXFdqT0IaGjSn/ff14gjEd1X8B+qGn+DINLAgiymH4Ms3EGFay4wgI4ZT+TtOPUvqfUlLbNidoJIy2VsTmqQtRGIu1f6sIaatD/Apd40DxXslSdsn0XU+7PrPAEdxX8nbA3vLxWVGX8GQuQM0tn6d/GwJFLBbo7KU+rzJ57PrmhaY0kPppEIedT38/qTNJ86yK0JSQ0ErAKncaqkkhOxLpo2DSMhW/LR/9e8IsXCTMvcU9l4VYNwFutcLXGn36n/L17UjwEKASn8fgmZGY3+xsrjt1QZh9hFbV6NQuufon5ATztn0Yo78kyMZ1URPR3YxJw6BeBaFiJ3GrULHQPdlOy7+Ij0pcVRWV1AdrEQ7r+EMW6M7EJlprolMfdwBL21A8QqlieSbAb8NlsIGSAhZo0XnAyI5RECX6WqYupHpOhSFkVVY3zrsdZrh1GdPCWctbIJz/XRQKSVklC1uCnrMsBfbUmlYCO5MkZUMYLBJfXWxAaRGCtumY7Rfl9TU72C1A+8B8ntsN1ASLw3Uo8QJxmmSyR/a2fJ07ZbMSTp5a15OitG/AfiOhve0qSRdZIHj1Xm1oOX39icEMSoYKc/V3IXKYNTSoCDptwIpDWB6Im2vRVVtq1q75ABQNBFmYrHYdZs/kRF3GEaYsUWMHAmJz9FDiIAlDrXfPnVyc92BW5tojhPW/LgE1yCTeah7x830NWJqJwGs4A80GnWxC1UMxWx1veR5k+K+1F9NqEDPjE45N/XwGd1wW3JIHkEwUmbKfJfQrkE/X52q5+9ROSudy3lc/o0yguTymAlLAAqFeABvzRcrUuCRa+74RSLyhV4cjqD37XmV4ssy96dmZYj+qyv75wwcdRpfJS+nWDzOQbnqloO1lPK9nyMD0Yqi6XMskXA6CjtdXtoXr275gb62baltyHziqMfvqyrLWN7Wl8PTRrpPYAUZeftebTx2zVBX3cwOL9PwpWlev59NzLI68BoDmKHbzRorO3qTskI2xd9j4cSDvzYL1N7IEi+v6ImMOD9zo3/BQH58vbMjhXfqtzGhzQ1dKgAG1m60dTfwnQGpqrQSMEXVwps8uPk8cZzo6bgCLZR62ycm0Uge4yZJtnKCFvCDmPW258fLP8HgNgBT+fJvfoUisv9Z/xXC0+K6rVL2+9pKOm+xTqWkxgKDX/Rvign5xuVWuIWL6t8tm6t/sU0GWQs6Ce2EmTSUlUzB8BM5hLPJ9wuccjQFSxbGRDcMQwYXkxqawz3naJs0WQU401V1IcszaVMYnl3+fDD0A42H9sqtjp2jsVzilz/awEeI/7KqgR1GQZIqyZx+IeYVMrtYGBgj1OlMjTIsjZ8GrCPk6ZcsGLZJNZdXq+jXJg+n7U/R7gF2/hAG61d9LNnvaF6YW0yctJUk1EvEfkVrLo9RUQxyLsK0dPJED4zaNUOFaRpziYjNMQLERD3cLb9mplJDKvV0t8036Z9siNRl/O3AProwsc0Xf8o1zYnmyj/N6qrFaOqhBMRg9YiqgkCTOBmLkDzxruK5T1uG62WGK6dnohXIkW0fcv5yN7gMJwgjo4ShuIHF6z2imnjXzTzPX2W8pe2Ol/RA6W4bgeFUnMt/9sb1kLSZhnBBCVrxgPF2KkbVxKGKqEFD59Uf735VatEIdS3wWtiXnbV446/ssXLViaG29Sst1oqwji9xOYDeeb4tpK7yfKpEjSTKyHCozoempeIzYciMhXDrlvlWJOjSKuNamOdMRpRTUo47pYHMZVvnzUuLMO90nno76AlqxYTBjRKo3gD4m9+981EkQkw4ahTMLyS0EvU0ZVJqwlMTkIjjGdhZN4MqoER7gsIOzMdtGhrwNKcU3MFCdDZcljmia8D2vXhzyYwzD6fPnKasRCVSFgL8L7VuTqaZpcQ/ifffQfz3yXdTEXWr/hH0D31aH4s3z851LubekRElYyFaVzbOPel1amohurFcmz45WlYXBfi500iIf/fYYQvYtfxe+NzuP4ECU8C/Fi4bk950DreEXCRI0Zj3XefwpMKcczRNdRZKRboWPTvo2M/t6bCNKAnxA1McygSUx1gqzVKqaF1IcJM2xqY8HF/SPdgCOarFf882tubzR1cKTzaibpD+c7BNpy+DHnIDa8qyVtCGaCbq4/L2BPypCVhnGaoVuK6oLsrv2XVFBgG6FQIYdyNcp21B8iWN1A0N38dadZKwab/SXnbZ1pzSQVsBKswWuV4MJj/BLCDB8YVKZ24IyBuYXXuZFLeIuj+BqdsFs1pSp/K6uPnUlxjThA+iTYjoXD6XRoyvXy9BXFy9iYsUgEJ8GRLvavP4q1be2F536JAdYgbul6ixlYMf3ft0ATtkV1HnH9CyUmucs+2UFw7rV1f8VRaWPwab63qgmYOuF1Ve4XiHsNN5Mrm5FkQkcbx2efmJFOzt5GJVcJkkwNeXtNVbCGckwhxushJe/leB9It/NbKpXyb0pbZc4YUSvuRDnd4yGfeaqAY0Sczgtbc8SsB/GKaig8SoX7n1Pj0tFgPuQ1ONqN6k+57/mNwBiwQS+ZK0Iq7guBQbJg+LUVb7IddmfY04Nnk/i/8bBcqeTV75m2iX+djdnzLkghkyE293PkMED1XWA6tCjkwN2pVRHOYW0Byqr3jKOWZtVrrTdsU7VeGuxbZwDCbBe75brMRdMYUFB+pHB26HOD7EdJAA96DZ6jbvJIyoraDYE9pHgPfoihA/hqrXyJaSYF+BgdLJX2xCDd7wZz6ZGLLj85aBj2gSp67dP2orGJ/WANf2JbyFh4XD/AIed8UdYwpSW5+1O4bFUV4bACdZwrecTyxo3bxvmvyGk4W7BW5KXhunJZwp7ZnQghccJ+qc+xeFdI1iFQfRPCRBN5uSTSvY3XD5tILGJWfooumGgP4Ole1zTQQl/bwy47Zs1RLj3dLW/oyZemw1htJFNC0BGDxkODC9Hy+KtNO9UtfIUchSViRmU3At6rEq+14jjFa/Ejm0t85pXFzNZX2kyU0QKtk0uyliZmqvAt00VJ2ma3pl2y3+7hDe6/CYsYXx+QEvpVACGVIh3OxPCV6UVqtY467WXI23QCAZW9GKTbohEbfaQw7gLp92yS+vyQrWZaTr4NxJbNaR+9fY/A3Nf7ACMrjRLdleVNDeeGiVSgrue+hlA5SqLwOFLxnH4fotnfYCWM6MGvcR6eoRoulG7PIwPQt815PkCYGBLcA8Jn98txs6AIy3Nk8oV2oSNTg/YO+SwAp4msMIGCMrZj265BQrZ/ZbgUP9m4zAvoAnzN5NzNBhSqd4W6OxFTeFs8pW+tl2W3Kgz1XcOdniFdHn68CH5PkPy3SNrdN96z4ccK2v9M0HFIu9Quwlr2N5gQ5VGuWpEZzYFeL67dzOvCI63XFKJ4F69ywW/l9tWP3kFSZD7BOY5rUWnw8tpQFuj6OW0cJMm9lxXgsKQt6jv8qTGdbt22/x6mwX8/KKf98bUaftCekCGjUC5+UYc5MIV0QUKHXiQxW6ke3K+c7Xy0qiEmh0d52eKVLsGiRA+dqY5W3Lr+S3lm1ALvmt8oLFInocvL1fzly+TDd1+YJ5UCRPJ84epQLGN6VJkHtusJG9PbgYXduOw6UNBuxceU+26aGRQWpHtJQQfvXCOP1okQG6STsR8AbEyxNZRPLpGfMy2/K8ybkw4J27Et2yAWAvVFQaiTul3fIGSmu1MZFUjqOYwKdOIzJMmFTqGMkjYeY7ERqyp6q/k7eIJm/Q6KJ1y495wL1SIuh4pBB3Wto3TUubL2xYKopC+2878UPM5awa8tkl7FDj3WBosbkZuX5sBdwQLAkUTBOp7Sdb1s6S+GcC9VEEyod2zc3UQuwdRJq4yf2W03Gza7D+MysraPWVfEGuaOW15xCvh8zZyw1CjSV+gtOFBn00MWLPaqpRhjfiX3cIFwZU4JHBFe1u0jCxgH8MRmYLoY5m1b64zKd5JKcZimesVnNJveqgFE31J5Ymmqc6nWQzyvf5hyx3HW45MRx6f7IP6MhLqakaDSlJoR74aUMcOXlTi9j86c51NCGS/S0hm5GwfU1eVpz+zlw9FrRlGBUMo2xC8FtOIQbtxXVWCzZQvd6H7Dt0uZk0SbThdZYVb39eB3sJK+9qcNKYDf3RjPU52v9bHm9AAIFMPyVBLOrzM0soGg16ni2TIemdXDfA1WNLkkKuuxnFQ0yxvNKcjRLcbTflaPQwtH1WF6QB1xwY77AoWeI04icSmgjFC6ay6wHh/0vQZrHxBmONeF3k1IAh9S0u6gaULxBu6EOHXNsbk+Fy+OOlDKKfjWXGfM1tktpAX28OsXa17wbbsa1uGoblbeBmJL5VLzYGjHeQlofLHt93TZzCPbsN1hmI74w0DrTVILZGqqP9XBS2flnb9hMBtes0m6BwMVik1Nnv9/LKq0bAAroYfhKCaBav2kjVDEh4xGaacHUykPDPQHJ/Lp9vtEtCeH7XegfwXQ0j/5qz40Tq5cT4uAQ9s5fqTLxe2m7ILCLRTcxQ8sDggHYaFzgWEjBh7JAIaHfz2xgHWDQ+tqAp/vzrtaIinQER3BmQ5LkONKi446aev/0/91VR/Hu5yCaVR51kcbtRuT74sd1eDjDd+YmN8+lfzyGSjjzpK3Eaxh+zqt2laNjzrCoRuzeqXTjgY+ESX2uoq83gZapunEFwVhU+bxOOo0hE5zCfjAGpTLhPIsfsLwKz+gKEBShM+UEarkTZqeg0XStD28ll70mZvUYwtBjcNl3oRW2YjcIozbymdGGy2quOm/uFgCp4lBI8DN35XfxzdGWdUtrTe/05Wl3gT0xHv6Rv7GPYYQlsallDU92NIFy0QOOtKR94DAUa/s3Zt51JrrAgwDPaFDj78yTQkbNQIkLhdFCU23g3F59Ckmqb22PpAbsx61hRADpYBmkGZqej7Ej0qUgI6/dDRmNjD7vTZYd5thN2ZTTBpUe1q71ua1F6sEpDDI7rqpz4A4g90ckK+D5hKknjPPS3u8V1SuiuKVsmpJPJui1H5udFg3/cjIQvE7PGWs+IyetwAhtxj1qALVTMu6sX5BbUsARj/QBLYjRiabqJGj396tykIvs/lCu+/fktWFKP0TfMvYhQPfHGunQK11dszR+7+0mtaSUJmS0/bK8zjiJLRRhWQbxk2J9awQWMpZUsAtWl8F2WIng98zP4Q9FJk6PQCUGBEAirEOYyKEqMmIWwE3wZE/WLqqpDCeW7J4FmOhvlzMpP1tp6svajoUcWvDW/ISvqRiqzUlT4t+1vlseIn53LQkGuCCZuGC0kw+6HiPl7IXnI58MUKJeox2Ueaa9nHMogyGmc5E1v2SaabQUCaWjb5RFmpPKloBeLSGIYFf0qyj1YRtAp8LT7SHx9087QFl6dcmkURfQ+9F2f47MrwQno+udPfc4W5F9LbbtZWbJoFXUTV5Q+QXmg/ZBnysfKOvBJpR6RilwsKFQRWxDSWa2WkUbZqp1CER6IEhKP3qBr3eDReFPpukk6KQ/dTfvZk/dGHmfGBSrJerUJ4CKevGZPbYtR1VIr1EhVhIxiuRSO9JOYtI4DaymZocKW3AIexxPZB9agma1AtGeZzL71n7tJIqXasQAMBAGqgoUIGOQ+pDw6Xgbygn/sEUfpqkrNBUJv1Ri37IlSNx8wPzdtULLK7E09gGzu956GaJGW+zg09Zyf8e4IYsiraUqGs10cfrvA6vsYFLA0TcLXiKyXaxMDvgnWQGkSsbbZ44DimE5cDJxnzoHJZPKzVkZJv5rePwkiWz8YjOCXDyr4gBK0h63hC2Bbq6agXhov/2bd1SDXVqMJPQWlIwgj1hRK9i7/7Usfk6pj4MxjRf3qtrAOYI9mPwasKJLZFgQTLq2Tyq+kaDUra1XwSFr0Jpt/4M4tXGkXEuCL7KEC+qR6jUqN4pz34++18qZAMlvWVWphAplYgZsq7Um4GWYT4JDSDG4JGEe7HZFug/USd+H8UrZbdrBmNttPYFLwfpFvOvQMkKtx08hWb/AkS1qPuqEPJh0SnEqLYLtZwaReryBvTL9heI7RXWCxgiiv6MLvN9lqPWPEs6zcIDjrzwa9UaxBBvzkCrsHX9NbdnFEHGazNuJ9ONZlU2fsk136poNrgcnbgb6M5wv0tlVC0OLdbmyCKgt6xFCUv7FpeAE5+UFNrssrmnYURNOilAoRBJeBQ4mDIzoWguzjgeseUzDEdhY/VlyFTgJkz0jJ6fu0o6xIVZO+Clr1JbI1Njm3a0+aYN653ocAUbkSwL+rsVPM5t9SpB4HEIvC3mdqqDr5pb18v8y0IVbJSk+jeCe7MAG05lVk/zMpd+05X6Dve5SeidJ+LlX5aM2LGjyHC4MD9oF7VAAGBW3NbKUUDSJIIS4ODp2eHU/a+/AtGo4+Y+fiEbhGt1t0ELMr4w0Rfgm7t4Q4P66RxDFA332CMN+8Kn+x1sLpzmWHE7RykZ/vDuRIn42ZN0cAbSrqDRf5WnBz8t1UH9weW/MJQF2Sy5+M0vsQQkgbJPyN23Rnz3NDohm8ImsX5n0LV1Eb+lrtYcwQQ5XqKaPI4+JrkbF02slnYHI2tudfmHusVuosZHduiDtJDHLLe6UHs3cKAFdKe76++eOYzyvSiFrlMEQo9kAtglnakdIV+XbSZ1gHkCKtAbOzuX6xGZjWsyz5Um6naJR/jq6+gCrWSEB9mNJPlj3UcNuisD9YUbUCF99YaQI9sW3ASEPkhPE5ZWawNIuQw7AZaTBSwPb5qrJJL6SrD3B5/y5t82AMJRSGPTqhCkS87F9p3Rs9x6855+E1jwXTbM0yU6mozc5/ClfG/PM7t0IgJuJ4mPjI7VqjvdcWD+Nyy4UMW7LnqKwCDfwU0m/iTpXQ+t+lflvSvL+eS4JChes7TnTVLqTXAws1Hb74ZMWubPn+MutVR2vG7qeIBItjPjMzAbegD34ZTkNo6hGIds0Tk99BNAHIZhbeTRwv+TVVy+A93uL4p9mg70VRRrYmoxsYLS0dj9I7zmkCX6ag/i+Uarc8lw1DAxi63/OaEgCAiOiMZvmghsX4eC2gXehNrogFPRy7indjvbVUz7A7vF8MlV0ldWMbqcGHXjIevlg6ZSFt7MGIvVX8MU4t1BKebUCgV6NUPG4zUfUKggPoYElzJOy0geBWqWUeZykMo1+/286pU13halUvkZeMPwn7MCT9xL/R0CjOjhS3zWG1bknTofHg0ZiXrrC52P3uGyuXtomqHsIyqFF5/1xiuU5G6wchJl173PL0ITgrn8H4hHas0g/fCsCC/8iPr1crBz/1rYT+3JvqS3sR7eoTmejDTLk15s39ZiwlMBvCQkXr5U98haEa47LGhrOdc2RbQzcGY61dx04vxO8HHBg9fq0TkErWLp6e4EX/r6RZySn33H8lQvgIRLOLChP45QTbZjoI3wd7kWyPsN3U+sVCnKkHMCpKb8vtmtI2tZcL2N8DbHMg1pceyGm6Y7/1eUCcm3+LgT3BJUrQRvlU6rmaXxUhZB6agdHyJ6tAR7bO2phA1jseVQ5vFG1ikx9s+vzrM39RuvONLQ0rQJ/xhi/KrWMwW0J0GkqjJmFwOsEzal4wLWzxDfAd/jMYA/TrQpO65irYKnDOiGjbNCn4+MJ+wD4BLlYsEGNpkSr4wul4oNbHj2KXVpDRYYf4MRlKkpkj0v6e6c+1tcQoJMfgkcDs7dTveoXAeJnwVAegQhG3kaLBAOg4Er0ZFaQTWWbfuJijCAqC0oU6oHeFJCtKDJ+ANoHLDWj+JtZzy8QJZCO/aar87ueD919WZkQW7H0nYuMsRd81AMP7/RVf8nTyjuY56zIDZPjMmXb837YOCz9h2ufCENzluhDPiVUXZXzrIEoPa5g9SxEISKqDvvm5AdfL1UCJaQhD8p6umN/c5FJujx2tss7ut434Al5MDzk8fmcGeEIItCdHsjFTvTm7eWzNIR2QWQ/OaGwmgvitmlkWxCRiUd3zh1LXtFU+ST2cw/9O7L3y+D3ScBDbAUVtB8Nq5/AHVUIe6AniFTghQEIniKi1+V6JPWE8/qkzj0aAdsdJBD8smozNfQcKpRta4rCW/l9OTs/DGv25xB1z/PUD/cPTPCTaEt2BQx07Gw21n6xOfH1Qvp59Ey4l+TnLAGzMtVpVA2WwT9LbxOuFlDoQEIIh1RThNo33bEi7eZez7VRIB15GVKRZgyevHPDVT0nBYLxJ7MpxpnousCbmPiSw49XqTPI5nS3LA61no26ssWhHfy10OGgu2/yg43L67w5cPrb1lrgD1sZOeCj/WQOckM4zMhPX3qO/5m0VrsyJSFWiWvxtgy+EdnOHnzJjPTyRienCZfuX99zSXe3HWX9o6Ke2VFkRnGyp+Ljid5N/fXjxj3b37pKFr9DAibKabwjIZp1gpJqkbHX48BbZTsKTM4YwNC6tRzokjwfAyHCb9n6jzi96VHSCdaCB6RBtEDqKDsJY21ImzQh9d76/BjwPZvd6kn/Krkmj551yrQCeFswtncFYz+f2/z/1jFnKi6BGVzJF/XhUEIws+RBSVwDzPk7v4pKO6CvInpqiwD5QIRVcOxsvEjz7gHv/c9zIwvWKZ8Ugn4l1ZD3Imtj6NZ8koRx7BAVsrHNDb0WoLVdvFgOfRteYDqnBftMyToow4twulUdobG9Hk0pI+fKvy4R8KR/whBLg1yU+PmmGH2Zl9mFjuSahQBVLPHzjAFTeuXUr717Xb04tvSM8zJxdp60z9V+39D4QLEEkRlaNG6+qe6acsQa0einHstjt4Oig+2ew5p2ok1LnUhdMDDcRHEJ95BtJ1eywJ2P5DXNQxSFrow/D8b3mJAn+Lg2kU6VoOIBkg65G1fFrTvjAAq+L30fzqdOF4Pkjpq665ezG+St11s1LTvKGShsrg6LuY/ocdytG8ExEfayMuK6JaGitkTI5u5/D9n0gScF5+xr0Pld5lNax1XiPCVBgczcHZXH1o7VaV2cIT4Ab/13G+Ib0yVx/d6GrQldIHt3MDwp5Zn0zecq8YYcK7qtKmuLF1QZNbs/wJ14rnPoIyJFHIC0SJBBZPBETIhmB1SypaZAqBy5METvTqz1uNgMan03VpCMzZ0TFqef1c8OmI+n20Gk03nqQfAns+2ZmS9DU+MT1zJwmsD1Km7HNYFOiKgU5Cfw8JbWbePgArG9v4ynpPJBgPC3OZy43IA8Dhmg1ANaqL9/C2i38wt0zIJ35nhxaRkVtROiSxU9ZFTMd7QERAL7o+V2ij41lbyGt8Uk1mBokq83OBCzcJvjwGxvf2bf/aJML6p5CxuAd1W/XX+k2tNvz94PwkvIqXSE5EHmuzWCaM9X3wduws4bBUdawMZh/Mwn10mDVq8/uIf51JybO1Bzgg/11V+Z4PIHoU7A3m5nKAyDeJhrKTTvHVkbnSHhT3CRqi5gVmeVFSH7HFvY82H4p+br/4xbA5lPDOKDx9Z0MmNYQB+S2x0E9GnQx2HjvI8wjPYklUeViM4Gna1YBqbD1cy/kO+wyDLPQOlCNrBDsSWeSbID9T8eDn1DV40Awfdlp+KvWppHQ78hHGHSO2sLNcupeWUz2Nd6EfNtSoNOfbILtF8rGDn2sM4FO3V9l0Csvc4ldBsbS5eVUZFC7yTXHGa4btZM0IKppHEPoLXYMp44ToK/xwNDBSHFqAbrSNQh2rbQmLxh0/aITixxRwYJS0c51DMfv/3ghJHafR02SRTKyThdMErInhK563RAuBlDraspG+O3/kPpGwJzMe1n12gRGX3Wq5AlLZeQu/cFFJtRZKKKI3Jmbm4AqykvostMBUS3rui3+2qNctABj2zM4wI+yZYM2L+zMl47+4X+GBaqxc2cGZ4HNVz+7g6VYe2grMVfWixjhKY5hySgA34MJct5hFQ7c18N2jyclqz6zqjJdPWucJbyy46tBnl4GgcWP2jnZEAWRZFSDwDK0KpNQvzt/8it4/U1N0vkNxuBRcdfLV4dqdGvW0oWZnLSoGvxZp9qxvqZHnLIBRjV3wfAwX+XLZW217my0iawRcAcTr0MKHlr9f6F2uBAW2kH6xOg67HdO+aw0HQG+wFjW4TyUhZyPThtUNg6GL4Yb5qwJXyCwtQdznT6RtGzi+5VEDjls2a0nZcIfH/L50eL83Ces/sEEsJDKX5WNEhV7s2ZstD1qyqX7lwmFj4OWztncb9bIn1Xf4iEnbuKrOYrjK1LwpCLcgEErqmDASA2oly3WlPuMoNKeVvU5vIMoh/Mr3eOZCVBmQ7Vr1WbsmJq51uP/JoLJd0E4eVux+hMcZfr4ofgsek0LBZnHCNGjtJKpjo6h4VL0cb6uF74SzCwY/Lu0dKUemnx59S+IuxF6siTdBDtcu/1KbulI/hU0H2F2Tj8BIItIRnkGD17PTGrxveQtA7NUb/vdpvyDZc4yNJwuY0LdwkdySkTb7EyhLXucziZj+rEbvKj5xIfj5/o+bJKkUv7/E7E/R1xP3OwJOPfzv9R+rSENDLMTMDImIi8tLZn4DEQKVS2KVqeU4Mv19RRJxPhwbCYuM+QueIwCxrQYwQlhqapspVV9UvmXUr0ZZH9uKa+ZqY8acAHEWlEmRjldjT0leivElIc+Rdzl+7ht7bgx67kx2Gd9PmRh91G8UUOKNPbVgublGnSsTfdAMa6g14q5ruzqUuURhXIUlx/auOzb5RZE4ugK24AhWYmoHDSQCat6TWWRFtXWvu6+aauIrIVigqggXThThzto7L0QmKcBwN8+2OVltMEP+dGdVngfj9uPsEFqyUkdGxFS5R1fgkz0B0Rtarc1wT0vGg3ZCo9fUY4Yexy5RdBM2fkoVxJ1ycKiODvg/5meKGsYMc88AwrDgvi65Tn6RsOFuKx0/26qgvhNpj7xZ9hCrslR0vnpYkA7qzOWP9hpu2MfW3bdKMwDtFWRVitjkxpYiSAKapKsn5kTM9znrM8alAevi1pt40KKK5a1nizwKM4HQTTQcHrEoECaJQ5qH9znLqCqrLQGvb/wyUgXpPfUok5qMt1Wrn+NsVfVawlYNdMT5dwiHXs2nRXFDDQ8m4VYebm8lxNEtDYCiwo5Z8UukKUVx0HVe5cgzZRXIxni0KrOmVbTAq9rui5tfG9naRZG5DLvpifpMxUl3Dkq+DQJKxe3wBAFAmmaCkIFnquB8sa3qCMgU0w0n00PHnSGWbs9YPDuJpcK7/A2N2RLbN0z2qOhHnZoGOo5O8AlM400rxpB8QCSHlzdnwrTFur7EXAE15LKpVhsrjpaRnQMRepwKYimZEQVPf2mzLvpzR0eR8kWbYQWEpTs7s+sAWPcyvlFt2yED1FzOMExuDO4E5vLXHtnM4TLpODAxXjDrGy52n6ds14pZwDiXyp5Y3AofFjkqn/YZmKBTSPgkt63w0SXohIGRaPuaGj8HcYYh9rQo/idydZfaZ/asF51P5SiQP3AYQkIRThlgf6ak/yU0DUtQDp6+oZFMhOCppCHyq7sWWwnijewCiUQcnilccuPI3ukMBiOtQYqMdCynfqcIZEGXD6GtZBZxB0N8gzXkhXX5SjddkDCDVAPJxfurlmsjgqReaWGBcTv311l6CltuIQeUXzv3YbkyNKeUSc1PmBWzZtfh9oCBOmsc2xeJq1qdnJdzJaOZDF+vC+2kXy9l3TQRhRIPApiUSnSQwYadxoggTafg9BUaXzs9rHqL+NiJ35WeeJ+sWlzCUycsA6o+fGJNC6BxPn2oTvcgiXF9ggNdMw3tve5WxOV//BRBVTp9wZH3Lpx2gVVE1lP80fCvO5Rw9Un/ktqnOOM3+/7d7lolf46rk136416GFk18BC/EC3pbJfllv9IULe9sBpnnC2bLWFQaj6+DCf+pGU8GWg+toK/eBKSk9wO8escD9ic5c1q/+YRwLdoo5CJDlekoFc3ZiSG+G6YrfKWkqOdiAmFo1Chviyxs1gb2iboLTngC0sPHaGHcRhc+iU9r9FxDARX5hkj6ehQM8Q002ZVZxSM5LJwy1WkVlFviIXKV047BtkSh4xjNOwUfz9Hdc1w12KbV8BsyNp7S2H6KL/8D8+8ENG4dXUkvVQTFaNbynNIvgdg9c4Hbd6KQ2p+8FQ+Q3f8eMcL60njrTYdfxoM+w880kf1X7EZnlgp6Cjh1D6JEiBXqVRyuoBpn4gX5ZzU+vUS7NrJJJSnnC06UvGOOym7nPRL2WutsCVGidV8XgJNffIEdrd81xPYxBmsRCRpJrBCyIbpA0Pq4hMjK3CcuXjLkQqf7nmjOeSqdLzPtuPy7W8S6bzqoCiRpV9ILUcnL0HyECJPV1+Awsl4L/gAyyKLq45qMCrAUh9EsRlhrxhr7aUcEmpNqGxDSyv4Z4xSg9HQzXY5ZqUDrCEOepRwlyVpGxVXjxXGoEAkNUevzbRS22SpNXH9y54OnIhV+1+M+HgFG0ezeL7OIHVmLSK6qemgH+Vfw7EmQR3xB287T5E7h2z378ITh8zkQ2FStv+6JIT4rBOsHc/zZuRvXcUiQ9aNRVDxEMBNZFgfLw++I8+CtGE2EZuI4eKr8qisJto58uUcmQlnIbgnNnSybTG+sGhutfmEcMuUwXbZdawMR4lh0sQ4kMjPoqnMduDV0Owkvowv53AObYdGe1z1F1tZm4MOIPF89OrbtXEyxNQ8E3+hA1v2QgJFzZdXnKshULbTl2j60P44qPyUmXs+arO5/TPf+EfHWiDbi36QeildMTD5PNCGPJMY1kcJRf5NN2HKUhomm+fURAnxbQAZ7/4l06vr8H30MCINbph4CnVZHwR3v7O5Vo0R022EA20pHsZqUJGAZqzBEl13+Prdym2xz7Ic4utbA6iYQFmvnU1txKx7sCf6h9LPMMb74aWvpJ9lOaOfBYugWVSy9/fVZV4qz4HqvJP4Rlz0rvKlHG5p/Qk73fCVtVIJljCTLzjnpuBQfP28OimGZ9OzsDY6j6JzAPQNWQR2RAx1R2YAwE5NxTvwpahoxh946xjcyZ/uENxgFN711z7IQtKc7LJVCa8kHutJHCiKCLgO/kT34LODjOYIRQwsb2LippdLKqmhIVTiLORr0iycwSFTZcc6mD/+rtH01QUVXkcmf61Eahl9Ca9UQrw4bTAygqXxKiM6JeAjsASAuNm/9/8dSLShfYrVuM57avpYtZJg1icsB5Ok3SaDz3iHoeZBCVyl5x5BwI2L6evxFtZ/M0eIFYQcNfKVmTMNgJFV2g5iu6Kkck5hD2ct3OMp8YIjccwlU3QSaRjGK0gA7osAU07DlMv6MCwhXbhaQUbocE525geJwsRQkgysBdDPwoQ6qcLG0b7kA2lmPl026oGsyj8QJ5U9v7ND5PqgOwNyzZMrpY55FdpDeA+6FevmwQbCoCY7V+gfUUVmWG9TvF0SUmkWHSf+um4n7/TjeGoqZpxuogZGY0NJvg1DBxY8zkeTctbW+/S+kQFfX2bSTDQx7c3cqkRbmmoc7fv2hh/kzxPBQU7Vh01g0t6KDG/72Y9kI6c9t93D2vMeGuq18cuLOXmr66vXbW+rf5+V/4nu0VzsdZAJGHP+2J77VfuCkj3GK+MYw/BHBpEdN+53Os36PUpiDMBfi89mRnI48Kbeej0/M5tvyzPwM9L5iUGE1raGZUAFZQC5C2MA58jmJ7TiQSra0SjEH3iqHsphvmKwbej0kRsK3r4FRzwhc0dQAXk82EnZKdYwLqBaaGLGScZJpXC0F0czOPROLWjIx0CpPL+6Z9N38ynnZRbKykvUl2xw1/ndsRs0sd98rYwpMKYhPcvkgJgQ5Qxm9rXv0Phj7coR2xH1IeXJp7YGWVHvqPoAEH0Ks4/ItgRpYahm0HKP51cVIdRAIy1wHcRpGjSVGmeDUB4qPwil+4ycd6533ecTb3wyCvB1bSEAC40AxooKfVJ6lK5XJzx2vmXBJUhpMwIQCcqRo8Fr527yY3tV1F9jFKmFmVeAN4vSQiLiwkAVLLL7P/GAllqNECKXLsF/eJqYECcAQLU8SOkWtskiSEXZJDxOtuqiqL/IHchbZTqN8va8pYqgb3z541gzU02Wu0BsLFuLAqQUsfVf8UqhfehXU9y+k/2Gy/+W2Tj2l4PKtEtYan7rNrCf+1TeJw0ycSk8n+xo9VUp8WdEdgXACpDOSUEknqV/N5n+Rh102cKU9Xwi5k7sh1iuG/wN1j/FZ9SUQqiiURkVaX3a0OFmnmD+5WRdwFINSxkHuzRZOOStipPbw7/PsSS4ntJHljZVpfnm/jEqnJ9uN5gDnDD9vq+pUQGFBEraVWAag8e59yCRzBcGc8CA9CY5czkmwJvsho4cAc5+c/EA8fN3y1q/euBNTpeLPCQI5qakZC626GZuBD1JldqsjVcthRFPoWGMjm11VJPNTpAbRgdVr0qC2ortJzz/k/Di6q56hrPgmk6mEeGVQGMUYe01r4wY31seO7VMMYMh8oA+GNp3X8CStZLS2KODEAr1J+4vQXFX3umEx2uHalLVtkvpFogJUHS8ft+B6SsYz4laTYG2gvTXKyYjFdJNn1Nuvk4KUUzytUVD+XjozbbrBK5A00Qd0jYakNmB59Hfq4arAMKrN122x5hK5JScTVKVQWxL0a5oYI02b1/alhX+URYl7Ho7LGMQtaHP3CMXE+l2LvdwD1U/h9KMcpcW+aJDhRlIftT3YdfGBoO3HwDJCqBgwMp3PMh2uLHnjwpHewUSkZKa3uezoBzxY9nYU9Jxw4rxOgRiu7mgad8LzJvvbEskh11AvaEsiXIZXocqmif4WsPcIHnn/28WzhvPsbeZKbGAVDOnE/vJCoR3rYOV4H8o+NO93mcDK5UzhO5VOenEfeT5FXx8/l4igOVLYuX0M4P4Ca+05Slet4I+1fWCi19nh7t38/lyk2TTaAJ/oc6N7XG2n13aFZoi0POL8qaRHFIg8haR3FAZCL0tDiiP8Sn+lYWVu5Uk2drDQ4RkV9zNm+Ff+BnfwnlOh0TGgTu4qhdkdN1/gZjbCJS2IEhBtklrRk819VMKmYplvxZNXaOOaYSwMhriq07RSok9P+NqQjDubTSyXddXem1upaQ0Lo08AKado8s89T84nJrsaMAhV5B6h346rw2ysLwKUzqkusegkJIFH82Q+7NiX/4l66ZTg81m5Wh6siYYo05nIlVCGGfhYVe9nC+8R0CwAXrsxLuQg/+WNdmFS1Kc+3Eco/vtsMZc8AiIDqJ/MoetpMeIKEtSu6mZERXL+jEIq1L0WysLhFRHRiW+n8jgSZgNs47spNidulO5EIhHb2i8Rfnmtl1IAwUTLfoVEQnhkBySwyULPg3vMknb9DWnMPEvGYR9/imWQ7e/w02SpOtlVtgVWqee4Qsyr67cGmPOT7XB0HYgne75iDV+KA6sg04thstJitAJNz7k7CtzW1W1tXBnuYy/6LKv2Zpjb/SPlIjGrTok59YDdJa8RTZurUAitlzOU7x0XF58llUF0z3dPX7opc7bFsSnzs6x5zfUTWh7zZHNJrxze8n7tRgI1+p7ItjJAeOjDweJ/zE4CAOOZzwwNlFwDBTPLGHXyMO04tzYFs5SYoHRL7dix37tFAwV5O+z6wtkNLoRQLnz6SnawTnGe2vSt/wTLxtPVE/6z4x/ibBJ34vvA2CrFm5pmIV6kddekXq2FeO+e+v5kIWjO+xg8zGsbw9oV+GGArjb+NMNCMjBgz6aI5XGUITYlBq/IbKm/bjk3IXNrRNi6J8KqodcePQFuH94Q4lJlBC965yfALjyJZr0nh7EC+tZMXgLLC7lIMliEb+sfyb4Wd8hQ2F3A3db8STl3LvFPgZXvHvzYQFVmiEPoxfUTXYKFdXK0mXt2hw/FxJdtMbOF9wGXQe4r+519P7T4F476kut0wd91/b9BcM+Tr5BeYXaJdq37RpenYC3mNvzK8zKrOQ0Owc0r6+PuY69RJBspiR1g9WfBGyX744F11aDJrfO8fmX0jmqSIdjGMCmfxFy8hujROlzwCyZumMdFyHmNydRtcmOh3Z6jdvnZ0kQov4+oGw4E2yB7yv88aVTW/pGyHCmVe8gCbmfoYGOVUVsggAJHHHuBPbQ3n5aL57h0N5BcI3Cfzj7Epcsy44cVrAf+pCf34CpxOwIMCBJczghSpkCJgTacob1b2+bkIC7uBBYCmN+PJJY7D39orhX11MczFLDiFe06SFTu4O4Bv5KK7te0NV7Qgp3fkGlYbTwHEkI/QXpuf/NpKyAPzxEFyjPibj691Y0TnJud3m8UJtPSQTISmPJqqxNk6kB2ZGvJ/FKItxfiru2HJJc7UH7HTayaffl56YVwvgVcV+uV9tA31gwulQLNZrJZH7FQmgCi+RXiNV6Ifs3wGSdQ6cpg0+2qz38wQPnsaR29InZGNTIxWtMwzoEf0OuqNYx1DqZTntb7siUZNol3pAZQEQnTU7kLk9bsGLyoZER7nieeo1WP/ufntlxu7Aw6SqIcB012zkjM4jSTSIDehTHq0KSzZnmSVlqdVwyQ7/dvESX0PrdKSAaWiDzFFx61KiJ9Uqhy4REw1HOKAegiR2wOQH9p+A9ZbZYIl5GfCuLPTEw4BipuQ/PT7URkBhM/KdJGvgruyNCmXpforqlwmIMhx2VfGXhCc3acsd16yL8HUxI5Y7TcZlOGf3tGiPeV57ppYco9Wq7Y3VEDfgqCiKsxMeCyPdwY00/hMqVyTcatN1xmJ/QM7No5/3QmeAX10DEtIK+tbJVybAVsyNn2tUyDkN+PbNW7CfS79KPiC5uhM5PjXoYayjDW4L3XJBuiFJQugGhH7KraiG5p8SiZPCZDWxY5zeOrle1orhcM31A2WYtpWFU0My838n9pnYegwpKbUvVNqcyBabVz6M/WbA1yzJm8i2eXgQ/ZOyQXQ+zSSq4vYqG9So7phS3Ii8d1ExOTQ1cG0tHFuqkOX3okIndasjrfTFg8yJJsc3A+YqDBabBWqTzWx5dosB9lL406OFLnYeztzpTY32mCWOwEZt3ikpTcCEDW2DH7AFAgJ4VmzaXL+jI8vzCNW8d377qWShZ43zHImbXQilHe1tbnl7Fr55lDs8/PHtUlGvh5A7U4D66ivjUBTWEL87QAK5Cb++l/FND/P330VhsgUU/vcMoDIwRmFoOZok2EL2hxErFfubOOsFH2ddmphC2tffFu385sK9V2VccZ0gNICMhqOxVnLIXdbSKYiHpoLO669BoXDMZj2UGe06V5hr92h7y3gnHYrNZKBZLUWa8SKdCGLljautEm4Efw76woxn8X1vFyA0VeE8dd+0lrrOVfIHPF3JQyJOecqFmMm74qYtSPQWsApcQ9P307VoEexktixE+f50pmAEt7Qu4D2SOpmgt7hrAEiC9c0WspDcLtkRA01RxU/hAAwSDsEwjPv/eyLZlPIDivGZC/Ixs+ED30uqjthMx5tN8bBAD/lOyXmJY9YF6Rtz6f6qTacLohBaR+F8sgzI1f7g0SkWOhZtHOBOznutaFUqP9KYs5lMal2R5sv5K69X32txKknklPu7+rh8CMHJwFWY/vLbYXgLytD36V02AXzc7o5wHlsSGJpH8AcxRCEhFZgELDT8qhmiqjzNzxGdz5JNaqLoZYBYux0gPrKJYeAU7YybTIijYFe2CrFrtwFPmR+Gg0J5cIMV+i/R2j/R2w5usv3fqxNIQ7h2gofh9d4lrxG7kWE8Xt4Aq1GcVGynwgJHf5OvQkk0nQAXdL7YRzzJBqlX/Wh9rffBG/uGKnGWMIZ/Fr7gABJ/nzNnyJjv+n1HD1joHkNEQnsWUiQJLYiiyx2eZBXyOVNnQtRFk+vVJAALaEvyTYP+AiPwFlrmA93VKqqxOvmB5TGrFjxS/DxnhthKUEt7F3eHsQNguDdg0IGROJewloqoynCWCU3ksWnJ58Vm1ZJ9OTJHPjmMkh8wrmLQ18ZElq4UqG5kmMpuM1b1PJwRdJK1ihGTK0vPfN/C8MT52XgbA13O3N+R5MtmsbT7jqJq/IW35CIPjSxR/gHoxD8TqvFZm5Hl+/YzZFTAdf0qmEZotaZEJEK0B6jlEqKD2f7YBz5Fi7+nA+mHTPg26l6BqeGAtvjlhZzPslrse2RmbJp5apK+aDrs7SHqkLCHF4QDPA5bdm0XJUvr7gGE0gG1VfP8UIlU5OFMTqkPG3HX2QWGpVcmg65taUrsbtqN52d4F+PpFus5oqMvrF5F3aJdRsytxHctMutlkoB2X+DE7JhJUbbq0BvBd82XbIdIRv0EHLXMh9P1NAJgXlcSMdz1vWZC9BECM4PwjlhlEystuGmbWh1N3dml9mUE1DlzKN8I2WWklCZJ1WDhFSJSWiVlbJ7RG726ZVB+WrGIUeG785w0b+XtSAy/wxVppt+6RYXYoqEAjTIBHh+Vrzkf5ggwZoli70UWiKrYuZhBRaKhNOLfE6qaE3xJicFFwSGnfaXmmTrxYxShdwlf58GzAK0C8H8Vqxx3O7vtNNrBrF2Gj8fGoNnwd8hdc+T5PIvUoY0v6UWXZ77RvlshOajb7Za/vbg4AI5yU77QliXRIaT41QGbE21F+dmSiQ+AvBNImr+6DPgYZU3TuQpexPXBQIqQzZCblRxNs70fabCMYxUHmMU3LH49y8ODt2InTrhOurOQQSeOizwUi00IpX7REgWHitmuuzQSalhLw0WUb0f5PeyTpYTttENGfZhCwJVFA9/yPK64MFPSPZm45heVSBGybvkY2H45/EOxXHTwzsm1xwEbS2E5C+H5LZsjVOXBcaFTkS9C6o2JyNItTzgiwvsS9VEK80xr4BJ7ljm11bzN7uQ402x2MMaGYYmCKhj3T22ifzcnHYbniSTzb1lFGbG+/HPJpu1Q7rc1X7gijhidoM+XO/TOHdG6kjZ6opPwRt98Ah5nj5+QdmrT+BA/OqH5SQ2C9r/TKSdrqc+pbNTTSCyZl+TZ9ZR9fag0RSAyfnRWqtQzjl8CR7hv8ZzHdBv5Dr8sjiBeG3k/OuBxVV34vpK3GECdTv1/4WILkreiSP1mP+LHMbNq8rG6tlCu7IFa60YQ1BQXbIWSofHifdm/e3GhYIiET9DiI1HixGD99Okoh6HyAX3dukcGnZx4ZyhaGZFW31yvEX0yznSKgowfU1AGOUlA33yjHWkQ49UbSY+IISxwc547TAdFJyqMoosopi2PFMKtj6PrXMRBE/18hUyjrv+hlwb1oj7LHy9pOUw3z8mIcS+1QjYABMWrcTUUgutqHCalixqREnJOZk+u9MVMXoWjvouOGpr1E5qu5NUJZCQwUHc5T1DSTc36B70BC1N8WlUmcPf9/FRd7YU1YDVjRBGxsLajJrdbqEE+hWQcRVeUt2ljIWz1GOUzUA/PkwFYzIQBlFxHknXx5ybCsutFRmn0wK0GGdMjGFrCCpUH/4GOzz4TW3Cu2HpdvVGDcuHEuXNf+Ns20jDa9OZZGy/4A9xCchCR0Ox4dwc/n8fAnFT4+okugQjaszbwKGvXbCRmWYG9GRJna0fPWKhQ+8WSNunVOyGSZG46OYlegqEaK/zb7yq1cOIJY6Q9RHmWSL/+/1zj3K9H5PvOY38H2aoSKlPRIs+paCmkJdmN3Ch9fuJmu+fq6XMT/6mIZPEOQRpNjXKzY5w7XUVq0T3xXVFy23EqNEzdCXyBRxqsgGvIITXpzeGjJmXb1A89kJDy5mHZKG+xsPZwEfTC2HxZ4s8ltws10llKUgSMuyNcwv6nSiuHKIdEQbzp+BpH9Fmc1VBrl959HfIurEf7T8fksZGkSgKkclqrJ38VCSJzjqV/N/6tNcBwGzD4yj0tTVlQ0rseuK4mM420QvMs4Sr47KrkmiEwOSJ2W13OUZwmOGzZhMME5elyT/zzdtuQnQPTOnr5NSCNjmveXPqwP9sdRrvNen0HACUtnXdm6tHLsH2ABMkq7h9Sr6a7YlQZqgUSxSBHtXWJyHmLMrhbTM1KeEJ6WJCfRZg1YskUcXTC4s7QD7SyywCj9ZzlAvJjLmnVn0fsN8Fuv0ih0uHex1e7LDd2E4Wgs5Pwa+JXHVdJk4n5kRNeAlwUbfN8KIVRWUulW1W0A18FxbZC2qZMltL+cIkqXVQOEx6m0FelJKw6Ax/mKc47LV2f/7g/d12DZPB+VrsFvt8ZUiRqludVaXPc/kIJNugq9hoDkjqnUqC/R8ya+Ajz9cYUWpdWjhYTURcsTIQzZ0w7R2XP8esu2X+iCJx4ZyHPN8Nri7y+ciJqphWBYbEoDJAubPyyl9HLd++OSN1Ao8GM8MJ5whIo/BHfopPqhn4BQjTCX1zyR/nkcZeD0MJjlhRHPZtbLqWrYwqKswq2j2fK0tffLKcJGjsp+pFcyE2qUvvpChQq3gwhSQvZHfuMO8dIaMqxa9fPH55aIdWDFGJqc2ukGTLrziytD1ZDCjY5lrt3+Fy7Zs+UsIPMs604fikdXRzuXwqt0I9UaXVGtWgoak2Uxt5pNT7NTyJOqlrWL35ysefjkw09h7bnZwRzwnH6wnPeLmUSdQIpqG+XSNS9FHUhnnNoOh52vb+gdXuI0H0rFUcU8dtmhqzXhLZtOa0l5e63N31BGn+WJ/BYnfTyj46q7Mz5EbdS1xABM+MJ7GuQt1WWbzHMBP3QHm3uXvv/Md99TvBaH6z6PQ4XLho4d8B2vYoeNnEljl9cmUcx2jluHyxxYt+6RE7BDsXyiHDhd71k0xzdadJmMIQ/iUw4lriMS2WX+aMgiRpae+94zZ9IGqGbVFMy+DQZakESKyuMxROj5cB91cBTRrxh2piNXpKmvKa85QW06b+wtWVCzJXxTNiMXqpcukzsQNOHQVQtvBKqPEABPYXPLHv3g65f99qogt6Yz2mtq5D+IBTLe/EpZguP+wr1V3f9DI/5TdavOYUg4SQscoQ6rnsQfCQlCzoGEJqAnkCt5L3DIIpdRlErao/6pv4jue7MxCN9CrfdQZv3Lij7LLpGa2P8eMpIR82vMWi5+LKr7lHSpzHrrGGRZFMq0o7nbzi5M4vele2sUcSN42yTdMXQirRP5kBPipDp7CYrKkfLx5D99y2PXt9aOx8QDkkPu48y1hfjtQsIuz8xNBi+qndv6EprZiefD6m79lhpaekEL5/3MHtbgmYa36PDlBDHcSkjfvnw04GT+fo4FdGm6FQbTvmdZNsqOZqt8EBFqKZJHKyqcQMuAcbZRiR3kzgtEz9jqo0BEaU2PCG8KN5swy4RptDmclywV1+O1gTNZqqejkwIbw8k6upfB159rhtSk+tuUhXB1L7wD1cyYiNUHE3ELQHzz0EdWOnN8qXcTKUnqFJQsAkHeGAppyNAxxq2TiRcWNE2Lh27N52wXj0D4cBAxx9KcGVRweljQQzTh5nwX3bjxflVgx+SnwPlZIYF8bbPH2w23i/LZgn0hwGNRSsUfMCB1Jd9TqMkU1fQdd5ohPVPyflYg5i7DzT0kMcAuyN8nGuKJYZhSFoF8o/yjthh6PPvT2YPf9KbYHoLjezCgZN8FD552TKddBc/inbmcXet5UbQIEQ3Pd3Wj4lDFtZJSLEjqQyt/LLABWQQ1dNcc3kNhI1CdhBJGaZG1/UhBdymS/Pl+ZL1i9HpN9EJapuQQqN8fejg1uDNucvAvPgbXc1V2qOiEusbRbORIu8DHREdnyXFCezRrg0WvR4uTpgWJBtGeplbSyY8ymX9tpoo9QX5jjvkBuDeJuEC3TlgLtSyyh6tPHusMM+ygp24+4M1EbxYMPfAndL+ZKCB8GD4QEfF2F/KXJ5f/ZkMN+WHJEPY8b9X3WI+YwII+xvPmb/Lettfr2Qo4O11X9QB8gQ6WBLUVhwA7T1cYW/yd5hRIPxhm3+r5qHZpwJKnWFiJGkQoqFeS16XMZZ8aZOwOkZpxxsro0V5c5bpRrdcerFjDC1Bm0jicSW5AjWz1gkKcjYpXNlPdCIKAZjgk/A27h4F8M++X95vLBa5JkxZCvTOGZ6oS36N36W9yzKE9Jj2yHE1WEeDuwT5TtCp7Rc2K8HUQeMX5+2eHfRyHbuPjfvhDsCdViQOK9iaGehMWbWlAAbgeqTVSPDbUZyOZ6P6mW6/X5uJHC6koQ2+ZmoAk30iypnub/n8oe98z9O1erMmDQFLnYDu2GA13Ma5Joyu7oXqcsRhtM8YE4rQV38HmZKWZH3GrrCQV9Pjsn1Wy1jp+ZyP5ko75Kq8i4u7lHD3GmNyYROAeV1bQWJKuCwb9RZPWIfgUSJJ+3pSFZT9YBdGBy4qZuO8zlUR4eh4CoXFYqSWXZxkIHwPhHsnXjx3OX3ff0cH1wLBMpbZp874ua1tIWBELJMhUAeAQLu3CriTbtcwzQ9T9iz5gGLHxpq+clXV+zrLq+UH7aOMHitsPUxDBDKsFDwkSIG5rWBZZgOZ+MXj8N5T+BclVd+aGFJdUBl106+kZzggW2c89ICnQXPGt1GYvSR9zZIEiAjuBwfaqikN12cVRtM5Q4UwcQkOYZUhHZkWUu9cgp3kA/WJqPKtlDywG5aRbiveMMa8nNiTzEBxGWf6kk7xyZtYTg53FjQmWuGeqZmCDsr4OtTKVPWuxzB/0wveKbjy/GWcd/lZwMff3JnWrlfa/DDPwXfg2znnH4VbAFkUQysHLXswTCATd+uGg0ZEuDfu12rhfGn4Y6SE/IDXYNWJGWBpJ9I0qFPpVzcw5SpyXXHAyADWVK6zKfZD5kQ6r8VG+3YnTbl8H9Wkr9GJHh+7ks7NAiKjG53//RTNnR6q5wTo/4PcAyvt6jzGJcARHajwY4oa37zRnaVJBafH8eBiyrHFJ8wvrJ29zyPMBdHL1vsbqXVatapLaNNsS5CXObSEGty843h9u3HhQwdRtF2fXI6UJF+cDUJhTlpDhHgQtGxwh/c3tkiVBDYm+h2CxwwVi8L0GrQEU6z0Pk+FWjBiaNIe0XClLrBzWHUDSm2JqTp8+F+NfK1TfWdENWVBuXW2/iTzslrXvzLz3V9AGnejkv0NroijinZYSMlB5fOhnV/jEGElWR8QK71bKc9ciJbscoaR+dy5tg4sHaeRaoS1D2DSIFtahTOU8/7YJ7mor/Oob4GL/wPO5lh48XGAj6OtAtActdxzUAJEYX5h/BMUCT5LEh6cK0PTqp6IJmYIGpHEQlCb4PPYFv+b2u8KHDf6p6JQwIY32sAY9a9ENn4qpnLKJ5hNEPCha0mh0jeWwJTvyVYpdwAs7jiVxR7w5G9snMnrxH7zJuddwMEJJknneluKeBFMUVJo0/CNrAal/Y16PEgEsws5I+D2dqSm8QfgKL9MZDG6jIkKNSU4ls41jpdsAIyKVf+DA7FMG0QZawiTYTYyNhQ7HqBIB2coiTOyHlcHHmOJUEm0u6YCifOLYc/nEVD8HOEH6m2zOA3hcFMfWl/p92yMOXmi1p/J7OJqrvAWpns4G5qLrJ7k4qH0ddmw8mHFDHo12ZZV7rRWKx9193+Q9xrvyJ+Mi0KzH6fm9TpP75dHQTgyYxartfs0a89SGQefQ+R833pdSXJ15ljVZJorpqkPzCgQ7AJ9mPhZ/M/b1lIYKyoSGPdpO8Jgoh45lVh5uSysHMuO2FEqSNb4foAN7lhqWyM6UOH1kUDbNSxrjtdOcjP0Wd69Ro942/+X/h6cS+RtBf5rAUnOTXXIwUdplWiuluApT4HeXA7mpJRnO4ryr70IXAWwRY4ergWyXu2emrXroNubY82LIIGMAXK3IUWus4uVdtIS07b4MWK/n84tXCAoHuAOP9GPxQiSAIFEbGURL4uPggPi9MRNG8ktzyFwNwgKDsY1/D8yRrOW2Ah3o5aYb3GAvuRHQysqyCBS3hB0d/phJOEcZR8UByCR3LfEm8bntohtqRCSklhsQiC7UIGX9ltTUX3TEIrsPiri0OsbWhqi8k5MUsASKOAyyl8Mp27GspjXJZL94etB7QHV1jeZGie9DbWeaLfnmpT08NAq3G67IZlxqSOYtowlsM8R3vVCy/hL5/Nbp65BkG/h+ZUCho6bjQl6iRnhL5NtybyogK/tNg2ofcwlagRZ8vsivVrwwpownBGREIl5vL/5AI0r+fslarTMCv7T75ffLPq7KL199OzRnMInYjK3TNRKuUzg4uIeMRE8UuLeOQscLigUTWHW2zYmNENJPSBEzUdMwELPDXW5otQNehfNwc6LwAO8vQ7klGiqXJLC6QUqp8pyksMSE/x6Huz5cPK+AczY/e5frA6fPfuXfyHlJ7S+5ti9kjJ/zPirbv+NCAKj7EN12LTk20dBz7FlZAtLFujSBdhPvvC3SfXCeMpsvqwpEla/aVa+o3/M0YWX5wwO+7j0MJyPYqq6XtjhXXc9GJvDPpIn33JEtUrgrkb8VKDI3qbF1X9iHiINx4ER88GH0KgQyyYwYzx7MOkfTg0t8sQ5qkyO8u9htOOaHum95/K2kjPoL8kLmzCM4UswvYUL9RLNiSS8SH7VKV7tMVSlD/az2YectbBCydEVAOQQ+Ub8gj/MdXOpdDUbHYUq/AHc9KNwbomjac7CmhsBz7KjHhb11Ibii8d3zQPFEB0tidwCi5RQv3vWaIfTCPo5OspR3bJEqM/NuLOHBEyQbMS/zSa7Rk/ksS/neBGfo6VVwEkZbm259tYKMpVewyFtNs/gDsi/SRwSXQht4zaDsd8RcUP1SdfPMyRGJesMBNEjm7FxRuNy5nAilaMeyMKTMEi04YD8RbN6cjxZFuPP+2tHRJXYEsWhNMj8W8BXmb+VVoRFrRToWpqQY2CCEq3LjXeWKI8CpGykQtPTqahnLqx4/du78BlriaICXMm2wlKUrOGcXX6gCcyrmAxswByzres40JQKDejVcRncMPC37pI/KG3W2uuyqQ5TPBAW9GcnVC0b0A15fX3Olp85VhajUC1Z2adFW6+EIQoL5+95Uff5pEtAXqdMOgum+ciKn/D+QEeRD5g/5LEhrhakoQ55MidpPb5Io9IxWBVmg7PK39HFVcwND+7Cq3FJb0xE3hgoRGl052p60iTJXuPOLt4mmAjAKO2KzhZWlN1SviuPq19A60mWM9vfph+kZGYDxLxwjk3EdEQdZqwp+Xy7pxH7WlnbB+u7y8Ifj/6LieR4NiglHmHNxsBkLG/xO2q/u/vj8DZiL00+zcrkvmidjsh711WX9dEfyxMkaaSt1sz0BXNE1aVCwOTb8e1jxktA/Qbh4ClWilX6yVGqdc1djUjVlRIx7zg96M9QCoHxXGfnkw3Yh3I25ukJikZFBsRF6ci0mxE7jTsE7ku4cLfsYbLH33IfsJQPsN6PXZfdpdtnHraAPsmH0NVTHYoLQfbhFrQjXXIvKV9btkf2ISTGMP5WbKhlfHcXNcrqaX4qNEpQBt5RTCpFSvombjABsZyOSYo2yQC8ZmUYlzH92gW3nCdesovkQ5ePH1AmY5FWnc6P0GOTo/7Y3jdvNAQEoA9AMLAWwSP7DCkpSPPjbyelLXyrcvDZoWOGHdPy1wvIkr2bSgApQhOXMDmhoY8x0rNeiSMo9XKiCAAFMSIWIKYtlFY0DaY1U7vWnm4LpoHA7qPAPXSNq00Bhq6nE6R4Tfslw4XIFiUi61FWagmeR5Lc+avhCwbH6B3F5iiE9YV4/eOc+Wof5ekYy/jkfDrdrRujyuzK/FMJ5E6NUA/MdJ/ajHgv6zYgkABVmvjnEW6CgYzEWPr6yWnGLRmBKJklEFRLpMASw5yc2vU/QsaYRhK4IeO/jOXIUfDNqP1VvK0rSaQGy7v5JyIhpXwzEhZl8el+26qhTg2AslP01XMbrpguD3eowa/G7YpkwWXvFQfRdhmXH47RE2Vj7stpA6HvhFstchD2Mu85G7KV0tH7NqEw4B732DTxoHNWgpxJTr4xRgROf1ht7pIwGbYCXcgCHDNc/KBwwvcDUCJxm2fLSY7R24EEVn3GZPTmTONYqrWpun9G93Cmpdyr4hC4w0dHwOzczsW/2HW0F2KWeVVwJ5UXA3+iBzglZvltaa7NbzXgUC9Tv2PX/JuKq+JxFl059LGu/cYCxBk/vt7Y6xSRwkHBktm+0AKHN126yiydyCZFw4olUA6t20tLJolioT4pTeD+t/nwF4mlGnSBuYb5UTLNzTl+U7ytCTx5oJm+zXA/0HUxmMel19+O4OuUViTWrOY2Nzfq9QFKgGCaZGnPZFmqCH+2Nf9PzozY94HiBqik1qTbB7dRH0ge9yeN9g0o2q+jbgopXuDBDtY4hYz13gNuyFiNvpaNT3F390lRFscbdV14i938nAXfN8IbtvdX0XpynN0+7wTwJn5osCgbPmDNgv6TB2HQBK73qhetmpCC8yYgE50hq5ArA+PUIDACgXk4yCBvwqUkpSZnoJ/xCJpDniaxSzkgJat+KHY8boC7DxPDQd56WjADx/JhMaYnOm4yR7hh1IaeD4oAtwtlrSJR5H6YowrcIWI4x9pdI8c66ufqYsnqH6rnsp5RnQCpRMNcbHcL7UeltBqMDiNjJGVQzfViM4y+itUF9lgJigWXHdkC3N3UfUqK6aH0lT/0L4c6ghVAQd6OWkkoSg0P60uwhfzLINUOSoQHN29wQLUhjS++k2bDMHVjFWHl1ASXjyeDw4MiyUYnQdscBoHymAhTmFgfR+p9NMsQVej4dXzyHmsAr3jMWO4f+38ehk5Z4onXALUs7I453x0wyYcpcULUkrt8+3UB8RAqavEpjza5OrOY5leh19wuFNuIcz7Qfv0FazWF7h18F7/XuAWCmTJc0W72Muf0ph513aY2RWg4v3IlXRChvTLvF68/FIcgclKsBPFEljJbHvfcI9ltd5m5vcnXwjFeOqWCQi05/ut0V9kbpGBjN5Xdompvs7VGh4P+XdSHOzm22e4kZhJcnxDtu7vZwU9NMyL1OoCef/M19inHkXQrwCduunzACo/lHrvgbPHRfTvSbO4VkvKJRc3ccSJoNLr7iZOLAN1NmwfTY6+2RNuIyB7E2qCPh1kee7tQtIRUcgNeFbXotn0jbomiOsR7mL77jAJQse86b3OTp9O/8Ipg1JdZVxStdAj962NGS53CUCuabm2cyvDNMhVdq/ocyETKaPar9G8/UF2DLIWRsKqPlzRo9Q+O4N+M2+UzXXJnGGAwyB1Pz8fcgYsVOgHJFxwjozFz3u0SGFC6TOcZ/aNW3TvLUogQ3CrFYzddSCV6vCg0VDZ6ua5+zpqtDM8txvlKz8Df/7w88ziGLMKnr2CrLTIqCLs0+LfJmNbcZlJpRODCsXqFA/GbefKf9nitUyU3mx/gNXQjqzC4Ejxn6iN975wyoyXijuCGLtr+jV2UIg9LvQrNyye6TziqtEGJiQmqvkhXiTRLpvFfRAGvmTFsF0HPRfUqtixsSXR6DOLDLDtC6UXndlFcZde2xW7AP0Fvi8KEJuPalAUU6U8JiJVZ8yzOx8EDni6P5+vub/uZ+WS0+sGkQnDxyeQBe1P4E03srE/ky3vzyW90lD3QduhFB+qf/pQNXq9LVLt1ESQGKgH3wxlMCgPktcdQPcIbGT3qd/rAxO25NTxYMPZNAS5rPuj6o65kNyOr1F6xfx1+mKTFQXpbR9nozggfVlB+mYqoAhMMoU6U/4D610JNaF1brYzwu36lIAILt5hDQT9clEex/bELvGCEJWJCqZs1QJPIgTaSUC1BkRJNbYac7g907eb+5meyvnbdNY9Q4hVVNMZ/l5bbErc4m4qGeo2M53BSINpsQ7ZHI77fu2S3nCriOuBc3v22u3a9bZsiypfPHh14sdnG3GsBYVBZKwJ2MztnbpOCP6E+hM4l0s6mGjnu83XAqV2QoHrn8bJoySReWyHlsAZW7U0eiA2iXuCYmP2yV7Kw3b2lTNPn+wBUlKecuvPpTZsy1MDF3yoJ92aME0hiilWG5MORaUDKfGD2Oa9ICKFqTEYbjmmx11n3dbu5rNZ3RES7Ob8g8kXYY8epYcE1hqdJw5c4OK7yIrs2F7p9QNzrrKSTMQRulCunAWrcHUoPARnI8kM22YV6lf8V6SpxvHQHcFdvE5AVYTjX2LkvZXDMvZ/rX9KRaI/HxVRuEvrJCBi8t1fmrkvS7rPGBy1hq6tdfRtoUvkUHNhBOm4CVTXt0OBu8dj2Am/QDMZhSuP8y+rAFLRqmMgXl3mUEUB21TEyn7vLDjWk4dJ4E++VOLfzYf8g9AcU8tjki9yumNpceOGpnKgJ/AeajZX4hkmDniU2mWMcIca2OEyxkLUl+LhniAWcHnCRBiw6NZViF9AKoHV+f28/0HLOi0OXtTmcJ+P3fBzOAcnt70d6uWIQTBwKCIf5nx0T0TilQPUbZo9GfbVVNO8a1C4CPm902RdbRZJyE8bI2wrrwGgeTbRoeft+UepYKpZSQNBCrUYCC1zLDPoYUy8bC1HnWbNMOOskfYyeq9lL9BgavzoeNe/TwUGo916fExmLK2QlrKPNivKLCYSutrwdMZ+Znndvo/0rgCGPlx74BC41mDFTvEJbTG6kiPdDKL1vHA41Bf4Ch60KNDy8Vtb679OGETmBUtwBlx+GY4lKw7KawIb1H0peoSNxJMkBe/QKDUYb//7Fe0zwVlGwRUVeRp20S9ZHI/jgK9coZQm1HWG36t8ZwFVX+ZTGySNNRZ2OmNbIRcgu+va2jK2428lC3uy65gcaAS9dxwqcFPcxC2Q7mPYQq4SCXtV2G3cpXrp7zromSBB911lEb4AOaaRuuOnP0gobyA6XFPf7Elkq75wbDHMPMHaT+/llvzrRcP5LSSKsjcUtHEvjt1fqQ6FngzPZ38eYWCV4JyI8LStUKiwo80FTRgZHN067GvnHNbM/y06AgOtV3Cl4eoiAsIenSJHIcpi7DgxFuXX5LuljkRrbUJ+lTIFsB3R3m31/uI4fA/4zw1RJPpKrOY7/+t7+r3s8qqi6lyoFwqXW2bW9Xovt9IrQkk6R8u4mGohIN0KODLyok+nTxPodvd4v9JDPTGL8WRQuKY3gW2YbsO+V8UY1dJXZ4eg8+bNgpEgcv0rnjZ7hCGdTb4+WGXRxK7JiTpl3rp1PCIXJr9G43SKf909OB1t4zgmAu9z0j1iq2tyG0hNvJsnG6xM6vmuxUQvzVXnCn/ael74vAV/Uryetmv2h9XxMPze4CPKLe3fhI+MPfupX1dYITPXo0Jq22quzaZ6JUhzRu2L89zIqf3a4EWX8gykahni3t5hCT+Ban/8Jgr12dEsOq4+ZDgpBvdKwq1frBSjFlBqIQXV/1h/usj3q/kZDuXzrFxcJxGaywKrfrFf1oGpwPSXv6XFijHAzZfpF3WT1DOg86E+Sy8/aruTblUTwQWMr4Q5IZLWzzerbUCqIozTbvzUiFLdf/nvd3X7nDv4bJPPBA2wupIgTlw5viL4PpPJLNt3W0Sne+pUM+e3aQo7TOPcu5mSkPBBx/4U2W2rcfpJ3WH3SWgL85TD9J6kzczNdxwj69o9QWn6h4KpwJlphMS2/xdQ/0y6KsthHVTwAfvkMWIe3S2Nh62ie17GLpKu5ZTOxTknNOcohQTHEH1Np7TuYtj9MRJ+g5h7EGxzFABbZHnb3Iz6+eCT2wORdHiKXb9ZbBkzWRPjPA+tV8W09Cf6fdbxLQ4UI0hQRh28AGjIvnfG6qqDyNf/gBPD84rE42LFTTDtZB1MhnnygqyQmmzC77PRtoBBaan8JsFhinY+qybRW5vHoRtzvoCid47nzK3LYiAxoJjw+RRSvXKbTRG9Nk0P8Lk2yci5yZuxoweHU9G+dz++MJ1HNSswT4tuiQrFbVpxsW3rdDbul0gloASTLyw4hBDy7o6CrWjX0QwJbjutymLpJ5D3nbDWOAge+vR7tM7XH35TQJAA4CGYahr66ox6Nwnbpr+511vGNnAQkmqv6K6T47FDdf8CBXg+hBDNbOONqbtqrIOQu/MP5UzLMNgcTFiNt4Yz5IeDDRdCrwvlm81Ajna6I7B3Ev2D1GqT2RVjE9ybgdXajAu3Tg2gaBvli93irlHzDoevAfldNAsB/XsvQZ+GfTzMfqZIKdsrF9Q6qnZMVW/r/ii2RRiDta/sCbYanpycETWFwZzs+OauW6WQKkcMclrJumrp+7AWOf8JjJRrgzxjir1D+yMlna3o2hGsqXkGYpcfq9izKbUH9qQRFmpCP8DfreWZjKrgyZWis8IX8rklanA663SSqhOqLiBuR4kBiEgtTQ2wKxJDBHqEosKn07poLLDcQ9bdYMged+ldIPrRZ3ttQh7x9coFB97rxVK6CML0XGLyZEsoTkexKne4jXbmsNjG0KheXzCS/88RcsuIgOxLxO87IVeAY4yR8+/Q2BWwrOZnk3u1/5tjoW6zwDUPyamdJdXICkJj5r2KvXtiKddhobIWOprZbEHstgjQFu0lMXOUtiz25Gvrnb3UzlA8AF9oPTwyJl2Eq4k6tIDQ70aYoAtM5P3jw1+o3Wl54pbjeV/c0cSJD4GRH4On7rQpJaXC6/XvOpMHNfFy6v5wh1qjGI13U8QmiLfjxfKU0EXazn/pqA6jjKZjOjUZ6YAhE4Ci5tf7Tcd1rblWTVJs4OzKXs4ofAybbx4Gv1Yh7VpC3bGSOE1VrLSXA160LDxOm0kI9TtoqYoXfLRtMQoiUfR3kQifA1EjBD4+IxPm9bsbfL8p9wB9jAsow8kx/1201cHyAVGZBmvPB9VANwlAAcMmO3BR+IP52yu7SmigU3IHoaHPWQ3z1hrImmRjPVAI+aPp/9jzI3Mfjws9MnqSffvUb0ubrv71PV9BNrruCHlC5pHTyipZHU2HXIqNDNW/WTaM8XqGArEmij+/uBDuPZfDrKvZuZgQzkHYoNhLWjoY+oYeQJOUVZBLDj8rg2ic9Pg/x6IYXsPpa/kuZY6fYR3p+yYzwb0595k07la/adoRg2yLLvR2gssERmf+/VHQM2/JGR7e32pPFrgOu+Ges/18t1xC/WsSBwble1yYUgaNvxySoDEte1EmzTQyMtP1rz0xunZ3ZccvLdnqI2FHMi1ut3/3BBOWXBuEmMXN+r3cQW2sM1c5moBoCgi/locw/MqogCIJjRNFHXgBIg52Oe1K1gxQmJYIT/uVTIeFHtG7oK7EDEoH/iy3UvoNvFXiz+Zn972Bs/nIl8XdHL2A58vQ3UCG9PHYQALaYvqPGTzaapfyuYCPpMxJDvi5+rNm9qfGc9RcfsOvdpqf9SSrVFdDeOmvR164/Uh/Z9ygo4L3t3E9TLHuTVVEm0H6ZVnQfTKuW38Z7vEOeku+i3mYj2y9VR24QrgxuMuiFzD4hK9zvEJtuDJsNcE7mfLOEtqhHXUGTJ3FSUZrJNDNQj1OwBumHONbfnKr8/jDiZzYKDB6PAaCiNYBzU+91Nl1kfs4f5tYhFmy2GuOvxpPYIumV+6MHOZuHfRFhKqVb4G11LmEEqQDn6muOombRtvNnon2Qi8b20ZBKSEk+YbFTngQcmSJQYWgkJaHKZgJm3gvCNGACXYIS2HCBgDSSJ3Xo1eg1ms+4S4zSrE1rbQU69E5TPixZAn2HNSv/HGEmH9LUvtCX3SV4IZETKYnf7e7SRv013juaZubINqqOTh9/n09T2oIZTr/Vn+t5DUJbbniVYCwgrQxraXjXlGoXspkrQPWNMPoMvynkA303hVVcUp2FpDqqUSnU3oxpsS8VyvWhYFfnqZYQa3p/tvl3qLjwjmI5sbMKHrAZ1LjmRYVv06gjWEqnG6nvRqCfQ5P/zrJpf6VffPEvxoP/wei/r6KVeDhS3GBmOG4VyUKGD5CtpU0wLXd8ZL58PQNpi2KUWuUXqBU6QlLrw6RSW04cf9AFACdkWiCIH8NUpv0JqGeYXLUNAUnb0LjRSdLRzQl1+MBCIQFC6aU8SNvaBg1E8VPVTXgX/jKjY9KkRMY1iBu6jr5hoNWkButSXuM0MeDuZvkuuo/H6MG3NCrvgLH7F2TLQWh6GULBxxd0xY2ZRWuMTtKTW7OFeTpg2eHegi+Wg8RnCVfDa44y8fpWUvUzk6HxjiIcbjaq68Vwjq8BBxPRfqDT77nkscOi/6pzG7q4DFqfEp0w7TWQSLCIKVQcEzqYHI9zW01CRxukX0aYKtNw1u2ALqxaq5GYzm2l9n8YZzUQHMb2xZu3OiuJWs8ynscYdy/4IRsXHRoJ3zm9ik+iNiVh3JBix6oXb2sWnLMrZ3JwQ79JYZ/yhbnhMFsDeQG2XbJdxUHU58+cLy5YjsE26daQ+PFL0Osim4+GGsvy1Gj0mSnTI8BXZQqHa/rrJz/OkMGUu5y8ilZQu0X7k+zrlgbmYpw1x1hshWQ+DW2I+/IToQvl/IWM/Lw+grQWnGPyVhFLK43fVLvvEZ55HbZxp+I5S/VELBx9j3JXLOVu8qT//AsDQ3JIxAzYvarmpz64LsKMLcxrNj+h1b0Hi2194dA5B+mQU5KolE/ltuPxm0Ci4wXxs84MDemVtfH9oMpMJ9XX42rchtIZxgDKxRdlFT+ifSIVeOibso4ch+uzygEIpHM/ZmyXth8SFZAHeGt4b26Fr1Rnh3/atlvRfencDb46UNpClQLc1ZXlKT4fgP2phowC16FXWuN6p23jcHs+5xyVtPZLQa/oual/Lozyk0DeAYZJImJJYGNfNa6BlhpAbs0SucstNn4TgLrh+aPpPiw0EyEmYeS1lFQ5YfeifYjlQ90QmYgb0ZlvaVUwqAN78Ey/jHRNiuvq5dMmzcOLNzk2LKCpgo9lA2MlL+736X4nwcWZAtNuMhWohErn3BKmj5XiF4jzE2HVxuqQTVirrAmOCjJTudXtuS5LrEoZmbrpExMjOjJw9dqjvNE3Q2we734QQMRI0GHNCLSTNqjlpFf+tGrd/Gu4Q9rGSlAE5DlZ1s8oQcFD0dJ6Uq/I8Si902yJ/QMmAOAvK9AY8y1lz+llH9KEbEOom1mC/5+mzYFt2/wlC7gQ/jYxztn0Cu4qepu5aYnmsLI1RSaoTFIc0Q9WeofTBmIiAdNatbqdHZPhWyILfS1GWkNysQ+ytbUQAGJTNVQX5SJhXdJjtSN7SPiUZU7Usnnqg9s+KhYm+2IT8G62fYUfVuRBbHcI+omTt4ikVz4U/Iu/SOur8/5xuPQ3LD4erv3kb/G0J9rmARdXBdP7KjCAW6uY9LtE14aPOlYaUUggaX7md5zyOSXQKPAJlC65Ei4hDqWOw65SVizN9rNgOAx7GuEGgyb0nUx0wQdzjQDLODKrt9WMj4xt6Eq3rZbfLhrhcM9Bumqn42FaIZu/siH7kL1kUhquEVh5YSE+7mQDp19d6cx6dz4UXq9/ytkXLS4IuSI+0Lll40ddFNAi63h8THc9WlvLRzkxrPVcrlfxN3qDutY8UIOKI7MxIWzPUnklfUDeF0GauLBakLyqg/ITxq/hx4+1Fzs2buZePT6TjevM/30E9bko/hy8FyDn4KIvUegVdq59zq2JM6sCmYKehCUpcxDSQoR164zT7dcDkw9RlkYC7FnWNOcVU0Gl5GjV9jnvwpgHfSQLWwvRlWLhuEN6/Ecbie/POs6+kJ7sv2Y6X4K4dqHP/N/pJMUBlHp+gbEjZPGVZ1HTTLRdDShwzHq67hsEuHbJTzu5B1gTLC4Ho0im1oaOMNevZGSwrV4vyppPU93Z+4qWvINqxpsENlPNfScC7pErMEkT5j+DPxWS8xBrUI1SxJuDuJa5JK1vCG6maPzr29KT+w3MkYMaOeMMNeQCTDsTxgCm0mNVhTeDaO7yux2pvRBV6bssYaNmqNecWy+XubWtXNLoFAp5rU1/Tu0M5Li46F9iQH+Ax7/k0Agj9ZW3XaTSSRQLDRGAGHrQKDH7X3viO+IyM0HhpccW1y1OkQxNUkTymQDgq64Y1dtGDo2DjHoPQAZz0z8wpSmgv9W+YPPjqe7vmTa6i7aBE1HDeLLrAj9KIJykWCBkH8vm9wdwE7yBmfxxVDqY/VraxQ8B6mJyKvoXAg3WqFIm5fdyZtk1wEVDItfnVgDiNMzoddQFncPXxxwNM1tdDsDhiuDk6iTdmiX7eUWKymEa3wf/cjCESaJWvEKSAXtxLnGiBNFE0BzB7Tra89rdG4pv0D6dqJJnOvuVFcC9gtYFR352d31Ob+xIPBtLBJ0ZNXrpUBvLmxSAXnGfCajXJvBa2SerA3t09nCBhGV/r7B0mlklB/u4ogGqrQYYOG6TWUS8P37GW+KgpLzq9HfdesMPQpoVRvOCfFZ+E/7UtscSWbI2ZxFzULE2kvqCPzZMiYUwQglQ6VD1lxUp+8yITsr/g8meR0ncM8VbntOR8HVXjLENK+okt6dAafPJ6UZwMUKHxFBCYKmUpvn0PwN/QZ6dXXipZ4mfwRIIKGJZa1GouhgP6BhWO+S7UR3rr0Dn7boKwU3DFpwB8KjMXkkXo4EW9YCKveRmEDMWmoHtJghfGyaXVekk1oJjfhsAP4GVuHW2luGu1nK+nGZCxM1Y0OMAHdV3LEXL36TV2uDYiRgYrG+Y+uW3mV8ycGmeOn+ngoL4kOUqwSSwKJmNlaAR2wFbZFe1Nx2c0m3kFKIA2viAF925vvhF8CVcDXXPCBmoPhDIPk0tDen2a3DsIf3ajnDSyefuzraJw4e/wM3kXK+gsHHcOZVbV5u/LdFJ1EqftSfuldG9ADZchkZh99W9+9gli85gy4bXzPrPyg05CM4E2o5NJWBrM9lMhSELA1ds/dP6+Px1pW42hCZIBza/v13oSHDawbiw3AWN/fV4+k4K4rxs7CiLM95G8M8gNojn5A42bY9JCqrqASM41dG1dlTt5eRp4SJCP8PgGcmaM6UZ6nmWBimiOx8qcIbjAdUu6yVnBJLB75eDzgU+YafLLjb+JVUolVaZrD6IYNDvAAVP9ukyWsQuafT1FyOZcgIeMmTQJ8Tl5W7VdGd2QERQNO8XIqPNWQvwiSeH3OE0t4NIDtb6XC+MKhP88JKAUeO1KOUakQc6lFt0t4kCuTcyVSM9CsC/YbDe6IhwgZW619LXBjK3t0P0Y2yMQieVPwv/BG8vKLXc0cnLkKvxLNQtnS27ideefyf+lHPXtPMkA/DgZSWaShuKxi/sNd3zbtyB1Ol9zhrgQViYkBODwzad9eTsIirHl7P9ZdbrPWwYh2XnC2ACYLy0OXlAniVtxW6VPS1YaKpCvIHZQIWF566enZ4XovcsB4tJGdF5gM+deSO9ah9ktty0dtiUuuAv3JygVeftEvOWpncYXRjY8/r9HgB+xElOlnmAvanoDgkmckdRn7aKwo6cyeDZDOn8a8NBg3yhzuGe0ofF73+SAh2+CF2t5l5Nzhber0jgDs0PC8I3zhjddE2NG3PnSyLnwFfpSqhWELNE06zrheL3Cqd0mGSfDamseDk4tZXTk9GowAXLxsTPFr5E2LOjAuIHyS5xRZUTt5qk+RPOUIHGPVabTMfiVyV4xo/l++d9X1JAWR5qWyCR86Ur5URIXWfTog4TZqEEDX6PeTYdQwjmUzGQN920vy+CSC/PPGC4nJmmqF91XxiPT7B21PI1SAwFsr5DZ0evJXjzqoB0bYWT30Q9iJkrvPlsmgOqH/aZrYnymi5kTgcERHo8tPM+Iy6u3BJa+t30qF9JxmWLSl7EqkjnFgJJJCkXwILVusnum2yxO62NP5cnziPPeBWzhHyR62OWfJonk0meahPVVgsY7xqtU14Ou/8Rutw8DTW3Q4X0ekdqhzG8bO2vP9rMHya2FtcX0mCXAQxB0V2uFSqgtSBAr79tI8/5F9Xr4CapmLrAQc4xrZucidwEOP/l/PhLIHN965A9+tNk/2mIOXzPKF4WNVB/GiU7XUSroflpY3Y8tJJAYZWGt8Swgtb3uBXywM73qfXhWaSzXCTSuBmtli+qNmxUWqmYbihVLwdDX0u9JcKQhJAxyzzShlGOspWHLzOVvTpMD0fFTlpVUSqtW8g5Rsuoav7PTsPULLvbTyM2wHEVcFjn4od9pz6J/9c8CsMFm/DrkbiSlqxcCOcErmOtuN0qBS8WjT48Etxg0qYHfbIRMSgYls8mdASqescWlX3ydob5o1smwsQY6G/m2/aE8XmmgMwTAL18tovzgORF3CMiIoRA9uQXuICDzSyoLqEF7wVylHn9kBgXoQyQI7xuakaZQEvtxn8815o1xpn+vYedca1KPDKmGerJFGDcl05cQz6vAL7Mg68kHcA8ccpQEchNvLYS5HOxkQ8syRrOfJYihz1J+vTActukwAw8wc0QTdK8qf/Bm/ejRMIgutJqTaG6fqBti4+psIRKYQoofQkAIwbnJUXJnTG7ik7opDKtJcil5qDdkhtM/Y5Fices4TEqhR2gJocfirfoz/RpaboXJSx+zDGpVEx5lDx8SdlfWgmL1f2URpor/uTn2AqdhR43BObS9KQKLBEVFm8LaTECoId2ESvzB0ILZje3HkhHD9JJXAq4lTb/0yPkQQpHBg8ux3yMw5BrAms0VnM68qZSn05a+LV1Ux2rrnzjNDUZAtwRxStvtZmWgEYuwPx3MiUb7JIvz/F0vwMiR8HdtyddQYtPaV7B0zAAr4Tj1xvs0LLHCsOfoNl/WJz039bgKb16jv5eRIC9r41pda/KuRNsHd0WVwkSnBcXTTLN3R0stYlidVzzPKhHWHaPohDyZT5AmBZQIbUoJTpfovBjhFuJbeONQXJcqDZWDneI4ssnSwfl3/+0WwiliA3SxY1DiHGhen3BobVAJMRkQMHD0XD3lroDJ5OY5Eh2cUveJjStGVuicMv3FJCTeOWWzySsP2Vc8c9i1BkYR02s1X62sN2ezPsYPKEYbgYtNO0ag0m5ZQULAjxid7LRIS+OYSG1HxgGaWWqZXiOdTGdJQZCTMckl6eogcPw4R5QQ/SO+rHqzQKtzMoa/x1GeGYa+P9PypZVPYapL8npvxVMaPEecoaAB8N5MpVQaJ4SwtDvimvh8oCu2c8CU9UXNGyl8ZOUuiN9Yleme4qTvZ/YPqWmh+GiUD3P5hBy40D8OELvjCez+NeA1BjuHnaALtYu0x7xYaEHZqqg2DXY3KeyOQVyMAaYsbVjRK3vhuStfnvcOaBIHDpuc9iliRvce2UdIL2HBg2aLWZVCi6sGr97glMAzNaQMEmNO/nh5TlFLUmq/jNt71zuirwrtj4RCWwsj4GvrrCqvQrvAVljkWWyiVyn1C/ghwmQTnI/jcNi3lXGzgUrtDnMsWWCxSPee2hdaLZGIKyWuDwn1s5jGp+6APvl1AlsI8AGjcS0oodoyyQ7o44/oKFVjri4tD0n62CsQAJRBh0LMvx9RuVjceSYKzqqHobsBE9s0c7XD+yMZZQZBph2hPJA33lIqdovJFGvy5hKH1difxFjNlXMBizSQIF1r3CF3k8HFMmwzmAaLbgpt32QD53R6507UMhyithYJFFAQL7oTXmXEd6zi0mchlZQDunQ3L+Xy+yHP1StYBWDBww2f5papT5fgPhl8k3TyqEFoVey3cVBwwwAd3QLXTDUVK6Flygm0ARBHJcDhMah7ROoeWv8FdJaD+Bct2BgzS5Wk5c0FRJLWxmVZzQLL69cmE7zERqpIWB3H4LJOKehv97pga2qCFLg86N8b+iJ9MF3A556RUIdVqwkwNmBzbQfkwYu9Oo9MfwLqL18lUpAA9I+5CGJ1nFQ2fNsQTAGXB3MzfGbuoq36i5QAma87tckK5QPcxerbg0R3u8RAcx+6pDLnPzUP5MXe/BByXIflmju7XvEKMrWrIw5Nk1u9uPQlioAmu8j1AUqORtm+HM+kzA7sh6OpzSyquOthhyC8fOFYLD0C2BrR2MUm9ELZEvu57vL9lNO5ZLt4rkKloTlTCmPr7JVvftzeLsYSgYZMaD47+OSzOVJ5qweTU+XQ9njUVLuka/7TPHgtYahbXAM6lkgRyUweDfnw3cOGGagA5beEl4oGFog7pC9uThwakfJ5Zm6T+HLatUHHHU0QbyqukAJTnBwD0dZKlQzaTeb7OWRyhCn81r3/ujmBRFV81fKeGM2opNjsVT2LI52tpqNYPYtx4sqrm5CVPTw+1Kwt198or85cCKFJ+HsB8uhIUbp+zeyXAgzNPoP9sJ4tG5UC3B8TE4W7exuWW4h+5hG/7hovkK4f+SOECsBZSFNeHiwUULcMxYyTef3pCQIhOzdSW1PtvNzx3XeZDN4Xe1hPISIjGly3hXYWXh20knOGhgo3jKi8gsSwU3wN15pAygasJmKln/VXE0k0NzsE3pM+4OvRtdwo7ZMBNTtfC8Uaf4CqyYULP8pACJjH77gvJgLbRgMZHfmJ3dcWDGN9KX9HnF4t8HeFm2TQS/0ItSHLKI3phcjD1hDudufnd17V2DB17camtIt9yGZH1q3Xo/cp4mej05Bj8tQOuP2zG91lN+TkcGtdHf9gKYeV/m1n/164naVxRbTJoQUbFdkwltpsPTYoDdIZPpEH5xn+bZ+xvtQuUgoLY5N2zJ5qRY4zyntEO/bLq7IvgWN8lm8AF83Nx+AaizdV4DcrhngvQvm+S5CwX4fn/wX/f6lxbLA5vOm2vRT17Xs/F3lsTLV2tHPPNLNqMgdIxmoFeAyuWg1HDP2fjNq5U7J+XE+eeysJGB1Np55zkwjJFS7QHPR1YSRuuK1NeB2posmjyJzkzLdiJCnlR5WcjgZheJ8Xso/IvO85BV5PIyeUL0aSC+7yZYrGm2/IQO6hxA5JZBnWSU4zH2Mnm8QLcw2PncbIdrwlZl33GADaqBWZ41LwJFaROgk1aRgFFlCB4A26UAenO8b/2PBgZUibw+moMSyIET0M1H9CP68CM1+vL6xp+LGVATJL4MNzL7r8UVrtwhBo/NEaZ6haXO1f/q22lYXrHzwvhZlkQkH10hYYJFl+53mHAlOhq6HvIk/fpfBRQmbbWGBAEyL5M1ZXSsioUv6+CqVdddvA3xlHGJSxgcVkS2v+LOIoNxcOZwT6ZK034fksRI35BcwJbk/rmXEn3y6zLCnN0t57LNe36Um/TO8feA8B6jx4PnLAuJZaoX5yMQZeWdDh9XMzpSAGqcP59jWSMLntBGRxtySeKQg80iEBBibqrbLQkADa7mZhLa7qys8ArL7D3ohkdZQBxBwRMmaUNrn5DNIOjxaWrUsaAKW3XQT54wojds4922GY7WXgx9T3u0x8dTnzjKVck1tuu5sUCbJBXkz3ZuD1Dro8EpDEBCyaZgj8DSes5nlEXDonBG1zXD1GEg5F1fI6V2LsrE3uYsRSgZL9NsGop6PKQfxKYid4eK+3L/W68c8RCu1u6IpaHyWnyEqHI350vzQCHg4esQsQeSMWgHwBhzwzDabhSvOC/IS7is6goE5n48QvxgL1EmwqrZr+yW5Yep6j1xxxcR1Xmo5oTPcBgbTfPbs/H0spyXIabDVpK3CVbd1c7vjE5g83MPkp3Q6Svop5V+9sIO95xGybHDKiYNtLKK5s/uddEMSB2Uq21OCUtg1v629cUW0+qdXa6BLgHQQCmaJaKzCqC/4lwXGehaEjsrf2fcEsNoqkImzXj2/5TAiFh1m925EkEwEutK6+lb2MQR9FRjJWOYNCsnpAucDEF8oxoOz4OvYMf2dDl09htjFNoP0Yt1T6/6Dx39NMrB716wY7U46uOecK863b2DTlzJ6p6wPUUmyKIjBJ8sXZNx9PKEKy1urp1k9WSiwAqoPV0kkBavOG9nPVtvM1pw5pvkU7xbEve9ydHNlfLrm0hVM1uwRokzVtuFyhw9hjBImbA7mPca1XPM/hCI8sSQP3jZQH1Wn9rqlky3ye6ylnzQGUGshillzwKnLJ6xfyY0gRF1QfPP1LaZ9mM6SaVClcbbp9T51zMzz13vTW+TDQ7JfzgWb40WEpOUVYTy4JP5bs59fQSF4IF4ptLIBoiV/kGWcV7I6qRWqiSxYwhjJFVU347+8zg1UT96LxuSIECOKzKFqMnSn2RCom8pifd0BcGWUmisbcTmCmTpriDwNJzD+bOHa4AkU22M5gylZlk3Pl5PoksJZ7uB09wzAvOmVzT1PEqSQRLMCU96q7XzLbW4UxqamuVnaICYqcmX2Bc8wjEQfGFdk1wGK3DlNXn6sXYTgN8obNgYcb9GtbsT/EjCi+bBkyuiLgGprfHg9iD3j3WslWYK37dwGqiSb6wGXQpVTgShggBNl5Q/DAsFbM2Kx7X3QFzSNUOFV3KImA5F00DcIJcNpMAUry0D/r1qT+qH17Ze91PJRM0aHfk5QIWSQ10JFydG7NipELpiZRP8h773TkXXQAprmiP2NMLni1CDS7u9z1vdRAaYL0j69PksZhtJoJAQcNOvc8cOL8QICgWABGF2b00iP3Lki5V1AgIiz0C6L2/UsBWRDo6DKylKTPQgdKIcPzgtgn80OtauP+nFkmsOoR9VRT7rBfhhPfwlND2tZMXdj54FzUmXVn3cJS+W7i7V6scUqVoDacoDGUyE0guxI8Q4Jh5ZYX0V+FIPhpfrPRjpbS04wLVubTF/InMJxIZJqOimuxcQhNtYyPAxhRjU/1zj7Lil42Ya7/Mw98VJh73rjOSgNg9YPruIk+PUenXBrA3AbJY2lAzsrZtsqnODb/cntu8GjwGqMNRtzE+h3qiZxsFVnB1ezbxNeLbHJaw8i+qp3xmDHadOkPmVl/Xc1nH1J2Vurjh5Px9nW1f57ncOmKcnJLfRLUhuadl+YyBEVrzwclALrO9AI6qEPX0LUPbnR7mCrhL62kHayv1AAiSBPPZwyUYy7zVLhnuC/GMRJpxNXifqWwyIMWMtXpxYgP7u2cG21NoD/l9NjvKMghoFiC1eVk3Kl6lZSA7kmVPpFcoRLEGMRLDLdxArgbPKtEIh58RMGp0vlq692bU187ukFDIrG039PwBhRS6S+wSK/uGQVtE31spow35ec+eMUm+Y6NwCXahX/AJaLUC/Zblp2jYqy4KwO95kHMFBpCu+mOg4Hnkw+KF36LwKlzSuej1TNWDVltd3kXAcX1QdgvbSXjJ+AdZUiGzYTLP+GWlQRsdmM+nAy2vzJIEydqZBZU9MOyXgkkRhzdKykz8lFbm1DgoFnciG1ReOhClscwR426XJ0XSvuYYpYbjHHrUspUSYfDkxmFAPlxJQhRkrAyUkt3KRldHNoHPfzN3OAc4ebWggIieYoFFgElNpM0QNZ+v6+3JIYOqFj+xp11F/9VEj8noh1OG0qbfJFkCjXy3Sm3g+AvHLN2OA1T5HBxtGGyRZCDi4/WW123zVJ41HXZV4XuWy4VTc+97HMIgm4NLSwpeDBtmmyuFJ/OwOZzdWchPN2n4O0gfMU5fPt5Nwvziv+ueQ8nJF5StLeNtgA1+IjHFELVMN4qZEsPDGVWye62ojSaTId5qs/K1QgNWpcluiVGnGdbnlXLBCDH8Sm6d6YkuCZN6u6GgA6LF7mEIHJwHOkmjeERbITDcf+uWIw7ZFTacFdMZPOeKDlGBu0qIekIR1jyAjaHMnUsv5QFivVy+AGXi+mb6oMtO+5HilD1xBPyoqK2OcJx6/u6dyCsTAlKp3T1tlQ9FUPRHBHPWHQvlfrSC1x+WBhz/mw/fQ2ID702mgo57i7+M0bYaG9WoUBnzBUZH7/3b0MgHiR6fbvX78XpVP+vYQgwFIRQ/MgV4icp/KufftPy+SCfc0wew3FMtlgzUesbeC74bIP7r1ErFjYiUZ23f2glc3G7FBpCbwqtSOwRSVHIPRwSEO+8ze8JTqaKD8CVfPnwbQwtTBBCxL2B13Tl43HA4C10lXbZyONM2P95uRMVKZtOyIfPTw8acUEQ//faop74YOwmvh/kkqAoR9FaYKG2AOtK214p5SfDAJFIRMtEGXMbIINuGtBQiSIOUEnYPqj5iLhVbWbd/wEbSwvSDzoY7yMEl2KTSE6wZqWI0A3cxJ3cnwXHdIpSp0avGB1ddNOB4XtuFjhGFqn3cl80g12Oa96bfwLbGef8jH7gHi+JD18ytROzz0I3FfEF6SjOAHtPoKCD3Y/l2lJ232a/NRfXgGXKTtljHA3WKn/rXKW1zXUFyg7ppO3IKssb904NVqTGVbwaPgNxxQey5fiexnSpeAmAUAsi/teWfkTuGQA9lMvGZpn3f8AtWT9ASWkaJcGftGmhWmAVBQNIVd5/feH+wmkNFBHgJw8wy5jIQAeVMNtRcFo/7a9ZEt5GF79mvY285skTjCzGcSNWlc+c6p28T5cv3yKxN0pKwBuNeYDm60sTYdTI6e+qv3cQifL1vbIXqmQvMc3KVXhgmF1BhhS1gatw9fn3LfMygbeZjr52QTKCZFOUgJ+sKt4u78Gz81h+Y+w145KGjm91hi8tBaqe3Qt+KIeleLTi81hBwMjBERpXGAGcRwsDfMalFyfxk6iYOdNBD/WlIUza73JxOaqNpquAvr8IddSjW2CcMRPjp1rcjIeczqugc33hI6+uUNEd39/TdZkJ9g5cHez8w4ziqvmrgln/TiAOzHptWGsXReglocZWOVGrf1omave9duKAadV6RfEFhcA/FzDP43LlFqrNM01LTzF2SoGQRiliIw5zyvn4vaz8u4/uLPks97XPA6TL8X0/HagzUusVZPLpJUBgHZzCwzp7SkCjXW/Ej3LCMegQRDADqAw6HW4W+3aQt6KxMhVHT1tVADRfB9Wrli/VDCiRAprfHBT8p4hH/SKHBcIwkyR/8mS8SPhHBlFy/9OoIb52od/ojKPYCyPC7CxFueNFgSnau1Ca+7/3S6/YGGushKS2LF5wcF25dohfC8pbUSphC4Mb9umzbGLZG/TX02s0Kzq19EfdxLrmU1H3JtSThv9ONIj2UlE6G/HpXCV3QGmrutaP1xnQMYs5zOxRUt2d8rJC0DTLNnqVw4WY10Z81Wg2P3o6rM/bn52kzj7EOc6s3aVhoAEoVItdbt+IRgJap0OINRwCndaDk64mTrNjBj6fTiBSaxP3Vm9cwPbPmCr6vfkRT9baoZYI7oSWW3EItfOwG9lA3dhmnxK1f4SnDHLv5mk1sVWOe3M1J1WF9ozhoz8cOPCg1FFSFyJo9RLKrmWNw52mYjkaawBQAa9FwcRIH48rRqrGM6oAzlCw7MEh6Kq8N+zLsWF7CPMY2UBISTLFXwFu+xjGnP6ll4JYbiu1G1jmkqzCyd459dhi5UeFYebt15wVDrEXP8m4RIgxrQF31VqeMOacIaILovuDJo0pN/RUWCwTIn0B7KwkijKhkq78hxYsPW38iWrNt+cH1eTAA//v2iGls5ZMqBlWwokH8KlVFkXjzeSCYy87JVrxQzvmASqoazQKvmeQ57KNEL1CDkTQlJGRp/HeB8XkT9tPLNBCdp0CB5uHZLvQa4tLs8Clp1kKk8rb38/nzH+94k3S5ACxug/rSVi8BTY/Gz5Jp5nmKoIImFGCthI1Lc+0OhxcSLIow1LjrReF1GWPdEEjoEB2GPzeIX/7pWTwXLgs4XNXUSMG+lqbMg0aoXcs8gfmD2i1q3NFRZiKK6U7n+szz5Toki2EuKsxWG/G5KilOir7jgCACGD8jU0GrbFrsLAJenXXnWCCIJR2K+SqjF9Mg4j+JPXNNr4tBIaqJ4eG3L4d8Ftm/at/XgeXQXQn68Q2raueczhmDPJr71g9cYZ2Gh6lyfLefgDAFS6b8noUmDKLtQBWG6KnMCgbmJEwQxfREpQHrYJmMKVy69wu/2ffA/1T7bDUEy0ArNpS22aZvjm/4GK8nF2wIPbL2SVb/0zJ3Jy8UnZyhgfAlTEwtybpMJB2CzuQkthbHo6QVgGgyKVAAwG2sD1WMUwP5tnn9xn4h+kgdLrdfk6Q80tWCeV/SY0CjCYlY+y9GnDV/O0UMreSTIeU8jqEanCbqEj2e4nspOWvRkAuwffbxCuoSQqO3tR/zcJp+rIGR3zahkuVWs3A1ddF+x/IyxoctG4MSpBD8gse2dfqXfRx1M28MgpLHZ2Tz9vPlPxyWPPpM5kyGmbyrMgKdEY9SqypAE91pPivNcDxq3Ed0cjxocfoVutMkwoE12seXcaB87n8dacQzdnaq+E8b1VV8CQryQ5ofOfhRUYAu2PB0/AwOYjfEPAak81pyAZEg85zrKelBQSjWqzudN8Zpj1oolx0wdI1TCENbQcJDwtj1mslCMo18ceiW2ABNAyALuixcMim0HVOWUJY3RYa6I8OISCG2BJofhOp1mnb2FYe4b42ytN58UqCCha/mxSJWOlrLTMGP7QwkknDty1JcJyFNM7lgvJ8RlpVZ26eP6lPaGqykkgMv31pBsJGPNVrsWiNxXB7nfiTAjfFTaeEqDG+WG12pD9rwx/EAEk04lN5hsQlaY2xPVCB558zf9NSLmrRje9jgQVgTVWCI757C8Q8XkPb8jAufnkw0gDNhdRF3KUsiqenN5RtLLp7BNZR+LDQyPj/NWYbvAGpa/UlL9wIEnmKrDPA+z6TTAgJW5SzV/UPxLAqhlwofT8fhuJiIPBKI9SfweQThieWP7ReMPc3diM4ML7CJaAQvvPppRASp9nkI7u9qpQjukOKvGjuvyuSLQVgilobhTeTPUUv0tO2lediVvI2XJ902upk4B6KCGOMmmVFC3Sp/64ScPLHejjzXoV5+tI4+lnaC/QyhO3xkxTeBc/N0paSVe1ZRrmE5CDkDh78Jd3Dib74WPncSTdhE+xYnuxcXT3drokbXGYpw3KOKPByfatWbn15LfGXXJPwH+EJ79RXaRzuU09I+/u7/6dZanQHBX6uP00Iq1J4RgWUwCLyToWpSrxQElwqHj/pVtU/fu5FTrMHS1IdQQGwz5EH99DTf5cRuOJbf5ZKB3PVR30LnaePvicWgvOaLZbUFe7YdeFGVtYouu7RS1SNPlMOPNpBpC8wx9wqlq+MCqTwC5/q0i+6eMCQILrYXxJzdqOJQuOpnzH3R3/LaBd8ZDXEc8zpQeLWwUWtCN03aTRZ+UztD+n25Wl2/B5W7OVbO4dY02MwxPnuLosrZNOMMPmnSQ2DFiPZhs6Z/J8EGNv+Q3r8tEVscfUOoDcIqJXLh88lsLr+cDkBkPA5RoO23WGSDsmd6gBaZnfAOfffmWX2TrMV49jX93wWmLgP1JPRgK5a9wMzWLiLKIY0G3WSiDFgoQFOrvxr1eccHS/bDFE4rbtMiv6kSiyioqJ8ivoVh3oKfvmqF0yi9AgewQ1oOruzf71wZxN2mDmTWbRkAOFTK/z+CN72x0Oo/e89y4rZtv2KUynVTm1/vvg+QuoOIWQcPUB0GfcS1ymXvJXJV5Fu3eDudtTza9oTzk6ROF3EU11/4/fa0DwK5/lWOYkAFoc1NNeLi7zVsFqFeriNxZIvTDPCOggHX5d9hV5xMV89z5fC6wVrX/dPWpJmkCM2ohBamNCijArotyfqjT8tMIcqlpvuCPFjr95gdysjKQ4ttimkBifrCBtAKtH56woAQVb7ajx6qJX8cBOKt0LdMkEacDApAB/IOmDlHpHMXDgFrZn1PDyn7mXSwPuZ6Kx8Vv+BixNLLrA5j46yY+Q8/wXy3/VhaaMK8HZfzoFRmn1kCA0MTeuZUkc6Icpuoue42QamdHBR2cZmzFaUAsatp19OuRuQslsoVQ2L7mAn5xjihSISJAnxZqUG12tW6rnx9ZlVU7Tyjwlt84CXhX18/xyTGhq2cUdC2fm/qh3mLAjB54+YBSKKDx+85IsSyPVlloFq/wjurW5Hqaycspp0p8CILlRJsS/v8M7EbNVhJYExcl/FB8jfc+4TDRkFfbdoFueRfcb6u22xPJK8cODOMV8elqUS8GNI5w2n4VI+nb3tjdJJdw4AvhtTnrvZInkZQZu0wo+n5bFXAvq4qVhHxSZyPCW5ltSA4M59cp36ZuYvzmruhhDDkXp1uSAgf2clTe2fZb0bP7kKk1SNL7+Wp6fOC/qOtfYpFPEyQ8CM/W78hyh7PMKRJ7OCMLnK2af9tfkonY4gAeH/0AL9yUrVn1tWS1oo16M2C6KOq/jdV8+xvGKtpQvmf2uf75wsENtI+LpjvzfYWUxcb/23syMMwKm4cpcY0GC/bJy8yc5AXRnoWwiNVUSR1w9sxjotA6rsofdIHFXnKsl/dVHJjq5OapdKevcob3ei0Ra6AhKffoXHdWdBkSVLU8DQNy8i269g6WwmFNfFj5XMnM+dXr3xIDw5jHzI4rZfB05lu36ICjEHBFWlF0Hxyqtuc5O1UFBQg4upqp9fbui47fWD7AWIV9UD8jZU1pVd5h7LyPkjbOXhzMBw7oesEOzRdFNGFF2tPGDPv25BW6fUX6/5Ram4paaICkXbXRpBYkw8ou4ivYFfR+SQJld1SLnm6g5Cn3+ivf2cAA6fDYoNDEM7v+4xgXEKGyFQBdaaRy85hDxxoTVrFbT4XwxS3bB54NeEnHtjU4ufLSsPBJxdTPoaOxvm+Wy9gE/bNzHLTTbhJNew7P+oSYwWh7kVk9577ITliCOnq11I8ySNc8usoWB+1b6vMyBDtAG7s47QFY5wU7RcTG3YKShGNEARt516zDsmTVo3YLykLJoHYJ5nJRH/JLXFlIQbkbNl5k6i4iLzzvsRtEQRAMOoxayog1mEcbRFbhNc1cu4KZ4DSl7XOqCWtznEP4qACcBQHaz0PDkX1K2oa36cqyYBAo47wSWLRVfQXZ0p4A7vln28rV9pTOAKuIrFCIjc6lAR124O8s5p9hSWBNDG3hnbEo8mBOGHasRCGYZ+WgSM6hV0EP9WOMcVNTuN09qSixeWNWd9DVtUjSeBBg/nDcf3+f/3LH9AAKeqXP0wIY1q/Dmwzx4SUTR0T2nZTSSMLZfAuB65J54r50luPvB7AOvkXc4pQtEFZts/c7ihcGOYMb+hmCis4kTKyEfLCeWU9FRIP6JwW0E6Hymakgwwf28FHQDmCZsGY8KZJayB/jMorAWqbo0tLCO76x2gL7fKQDZ1+0ZVk0XJ9okVI9YG5a6HBiHLCC/+ngnpC74R0k6mFy2JjOgyuhiPzO8qojqP1kAsy0Om4QZRuWW51WxzJ7mFO+5gZMViJbrb/CSbXkNVDBcAgP3+OvVgSOxmuc7TVZNuUMJw/EJQOonCp3VlzkG5eZzPlCWH3EkJeNGOwOvkZsvf7Y2ACWalQ0LO3FvdU182RHyA3vbhzyRYwTwyfyhMNtdu66unnD1cGRceMs8864RP2TRWh7CWpUIzmMXyU3dEUp+tiKYE7/g7hgdNr4Tnxt5kvZze4Rg5xCu+n8QmbDV9reooB9agCM6ZRUzW4wqwReZ5LQd9PNn6q2XDd0pFPbqz7+bWyus43L1hj32aTkwjE4yLA5+s7d45SfCEBz4yMsRsZBTCfEASbPAIpc/ax4NkXZrhzbhp7TIyVOq1ovjfG6CDdXGduE1QlQnOynGpQtKitPV7k7F4mEMtpRQQs5oBDOVRVQvzkMdpNXO3dc+7aARSmI55Ff91ACyEBfqrf6Eq39vSC3sk09NBGVN5L4EYuTY5BAihb778+/AofYKDYMPN0bnO3uvN7DjPmGP7bDrlLYYdDcd/2m5SFwgtAKwzyDquyRLgEndw4NStEv0zwDXl+q+99895vd5Xe5WU5JvMoR+qmYYj4na5D/iV4RnlPNP4DLwGHNBSKsF6mwiY1gjlLQvnyFqVEr+ahjXtOTEbeVYtpthRTubuPkuRBSUVdJQpLu99RXd3k9oXrP4hCK7M3rN+3qNdLVa9tkJcAagGF+R+VqiNTQ3XwK+Rg3C+H7K0ziCWMo7LLBy93Bcmb3e767XbtwtTQRhb+A1FWD0vyFvfKuDB3cci7+r4g6qy4zZ95iHFz3B2scIZdKBna9nmpgw3SnZNWivwRAG546XJnLECyU4c9NYgpgy2aL1dJiCa9aejkAe65pJuLepxNAjaE0SNuANfrzAeI2QU939RSWD0lzCajYzFpGOwdZekHjx6dzq0Wewb/bIwU6UFqT2Cx70pG+ykxUJUgPNXE64Ps5+UNHA2YxsKJCxDlUzcm+a+Ls2G6Yuy+3Tp0T3XPGCkARoUiDQO86hyy9wut/Iy5dCo5z8KRbwb9SMVeV495OdOp5JHkFlczeb3ojbOfypkoAA7lMq3013fXtZw41m2CvaUhEXjknksjsv3UNpIrhg5yE7Abuxf2WFf+R3SDABbFvQtj2GQmiIM1FmTsJJgveH8xjIni4iXB3zdtZ57uzdd3biBGyLT+zNFLY5PnoUZKzzmfXwqjKBV72zdDwvvckBLzhGjAMVTO/xE3tcFvC1xt5wTGephedCG+o7BpOfRZG6hni0vWVpFyeRwjWwyy9BpX47Q9lqA8KWDdQTVFozGINAZeYsoZd2PJl6wpGQuINhk47Bc6yPzh99Bxf8SrGrcYuYN8LJrsFzZF9082/61vOmF3TbbI+OxWaFSv0koekSGoF5+SJHz5Vix60tn722MUbIzRWKUuRkiPtgaAaI+JVC8Wlw+e+mdI6fp1utRtuZOLXxSaWd7AKExFpzws7jm16uWIhjsryvVZHAz9krUhDnD4NIsXYXWdTo6g0ofcn6Ko8YGIk8w7gjHgOAzdndVle+OMO8w29QTJ0YGbEO5/twrmRZ2slh58LuownIiGXepyiptl41WxrszpsrXQRj67Z2c5w+hIB1t+vMPYCe8WxRKQ6SS1HIxPzpLoTnm4BzztsL1/EKZq6j+8xeBCx+eYGIUnAPGycqegJcOzgE5izsMKXBdH+oXhGMvv5nTrqPspC6a8FpKlJvuZOc4qxqi66AaJVS3RLEW4xOrLn5cgsVsU/imdkYx2gltJEzpi8x9N4iqgs0FsVWsYMEvyl0SRtBwshRsWEog1GEQuDykSjKHR3QUFZ/w6yerF8HgM2GmE0L40NCuIlD1joBMK+KV9KX1nI3zukGOQu0yzn39Nx0XDGgr8UG6M0naq6WXaTXVaU7NrUUop84Y6SCOhJNuwHEKT7iHRkmZGSEpn2UTd/FyWPZx9a8555dYx7Uj8tOBLPurfT8RzpIUDtk51McZJpsUWGSnj4RwW+ytteXK7/DlLX2t5lkBw5xL7GBo1lju07oaevTzObhDWFcBjptphxTI3DGVxQbHVpc0zj7NZx219mjVVDsBJlgveMIG3rKDJe7+WpFCM0JceYWKQwpoRD69jsfKWnIkTuaO5apR1skenEkdUJO+R5nxAlZ18/dLF6JSPfpJe3TtMpEWoJX+/adMXMLmBdzo1cDR+DPUOO0V+5piaRHfeXBzmO5CKM5wh+aYJvS47O7X9iT2LRN04hslOKXYI4WWn9jRan7klB16kLQY7cYSS1gS6O1O7CLB4Kzx4ePO25KsHDZz/PH7w3ox+drzCC7AKugroS8K1Iol4fbQAC1FbyKCwZfs/nmaaAQY0+GsQ202d7J1nV8b7awRmmIo0LCMoRwVEQ2TKNfl/FDmFnMUsKWyMyZGg6ebMi7s0mLEmTRPNiqmxLrNClpM9OCjDUJu/wXIDsG2RNcSgVdL2MOxEbFu3iMISl6O67LQnXo7qEfPgRjzOFPJBZ7fLW4/tejbYGbwHqmjpzTVACdVei++xNEPYcuT57EN5tKux/2NOY72Cugogxs6W8drB+0R37DxnN+nhk6MVgpbmR+deGfJtheanYLVi4bzl7cBXuRDzDR7ybl9puM1iXTjK+PLF8LD5FniKDi06RhTHAQ7C0O6ocvAXNFR/Qy4cnQlXg1BMTfCH6taImNgVwbAd5Qk3ialaTCpYcElFkTHaMoiahoUXMF+3v868i2Cb3/x+D2DIrb9+b0yuSYjn5akc031tA8HFo2T/NlIqFl2gf+YhbPhZ4VA4Gj//duBrwXr5NkcsgjrmBjG7LO1giFJNLgDeMmHyvT7jGxYzn5KHROart6nJZypk0x1Af4DvgvkY7tlFpu9FTj6J/fGBIYxUNLSNzvImlWt8n/iUu8p3W4ctdPS7ZQbBzYSjxiG0FOdUTzs1WWbprcZ1+JW7u3LHbpHzu/tJ0A0Yk8ueOLvay+5zED5cqGfDsHDJC/KIpIgJWzthD9yiik9Fk1y30A71WSOx7lQVcg7mkhm1kdjaEmJF6PxmHQ7zYW3/DNQkUKUmrpVyOBkVAM0+aGsYdazRBmeB86ezL9WS5LCtL7HbELPI8qB8UVwqz+Zy8h+YdgyVqHnQvbEvpgC9jqBXkYq3rP87qHHDG6zi3gCOJoi6v++j36bawBz2cgKZHlbaFPlv1EuFsIj6P8ewyisqEalIMTTARfbpaJp7HpXTHGivlq/BPNXTLQGEPbEaqPqwALke8RCNfjHdIDzMTE8rtml2sSLgQ9mR4+6L6oJd07vwdh8Ar+9hCO5yuV63aA/ltyFxs6Qib2XAyr9+jos+6P5bxZiCG6vrgHVsSgBNuaCpFRlBje9ZRCqIobP5tV1QxjLxrZ7qhWQMAiEL7kBv8akHZVUMKUDlILMqYVTIkfmry+C9/ECPS0fq1LiEw+fkxun5r6ZEvqBFh1lhCoq4b5veqljDWPrrAAWRQNNgi357dvBIIeuczzhBq31Z19svJxEkanYjLu+mVyqaxl9oZdJS1AIZYRRvCza0CWnG/gd0w/JqaT5xr0bVTL/VB5K0L9k1tC8Y/Rf0V6yVeC/l44nS7GKX9iAQbpbYLIU9OMhGGlnrihVZPip8H2kIvTM20TUwOcest7iCN+clc18tI6rs4QIwg+2BuD8HzJvtPvsjV2NF7TkE65NEaLbHuPFBSBCHRtepzFWBH4CIu3gPwCAKKwcoVbKDKJjx5dR2B9lB5gcxS168L/gpeN/iDzqIYyomwP5bSq1cWMgaCSbLqqFpiNVpqDP0UyiOVDeW9aCyRBWyu5dtQiinmjR1SNet4u7u35MXCpbJbDUk37dJWTDrIHZUMtL+X3ZEjCS2iiCuitR8rRhgD/kW1MjWS8BxmbILcyddJsoM5L35wsmAdMVzAiqYV/HM0LZpOh1QzVaAlp9A1cYlWh/IQnhqopLZrHWY1bF/eNq91vzLAx5vTPPaKvBUzgHVb4oCuiybWVggumfGZZNnzc7LP0FBQHF5o0dm479QuROgDYoKFBNliH83dkhD/0Chyz5PrxL25C/3Ni6Xm4SLw+MVIZTB6x0K5KASxSzcHOFOZqpKFXtxVW1gKVNExS3BTCLtRO1spdUcJr/ElA33Bwf/JeS7HNjPZYQr8PnWAgzrma+bVhw0a9L/iU5+XQdkviyElhrmRZaj3+kZRL8LYGCFuC7Oj/02ALmee2Cj1UUeKNnRt9Ugl78Ujkj9JMdkLTyH/8/XfI3AV6PO7RA+TBq1RCTrYr7xVFX7VDXHo+RlQlxWLUprhEk7ii1rh4ey8kE2uL8KD0NUBcJLWbwFN5fTcNnQOrtcS2tAlp/X8i4lwTyzXBCLcXZK12aVND6dX7Gp0Eyzi+MccuN997RsvhCB/WwmO3H/aG9OJQaCUxU9npfklZ/42aAN4D3CxgngpxHJ/qfI9dY1zbou3cz+R+U7W5kL9/jah/xETlagEvoqiN8vilTSEnQHdw0THUXmdeFgY0chNyFxv+BTpe+x8UuqHLBfTHx6eX11wWX0pIMMQrzwAWdNxY1tjZNwLwWtjO2BD+j51XAHtHrKst7zp6KiekwFvLTMqgvGqEY9DbTEKUb1EzzH4aCOnYKh6ZoWQmOx3M1Jv5GxAnA01M9QVg6zUu1KJnK4JLaNYtCelXGwgsCEOYjljc0VC2geafgI/q9BbtQpl2cBXdL5iggfCHqravPLOnBDE/vezw+hRlHZ4zY/mlonEUa7uyVs0My6hb2I6njItNr+YO543DQ1Ar349J5xtQroP1XD9U+UugtuUzHey6BIl0L8p/iCbjIOArLxD3wR6DkF4yA0l+0RsHj4uAx5HcL2EgKH4D+jrhakK8k9984l0xEpvNYCEEnzjX9ZJDxky7cWKmlh1o9Om+AOkcXmcJjgIclBkzZ2zdS8Xg6/gFPG4YczZTErLUXuWZrOPLxydWEj/23SlWmSqxbbo2/tpdil57rQpTpLyY2OgjKrC2Zquggj/g7I4xUx6womevO0XLHW7ZSedaf2cESBT/HyfRLZ/9lUnowuqf0NXTuTpNtnxT3tjC6F6j+aG+iycx3FlpVSyhw+WTfqbWNBqYiM/Enp+duUPmEVoGUyEAYnRGLyKAt9/wG7xHi8REtoomB3HpsPsqIzndRpLw1TDc/cJH/4bky7Y7yOjQKxzbiYyM67x9fRdz/Wr3FgRl2j1nlB+vOT7AKFaHyRBaldbqQ7YXEvAkI1JiHtYf3gc3Z1M9C8lBUavgim4bMaUTFUnky+QRvI6TrPV5GvgnFd6MUNvsPALfaARDMvGomzvslaeQ89BmDpLwLd/9dcIUcrz6wz3gpYHHDfuXkmqHR4tVb23jvdrQbb8/uTvSwmVmJ8x9kCEzf3cKhWjp6vpamBl8cJMKFHeBDujWNEkjmZzfq4vq2jUMKnHFq7dtTjM8WOxXcD/sk3x3h+KnRDo/qXDhhL2XJx9j8vWRTqCqcNNBTyrrP5QAo89CQY4rCZfGEfhJcU5cxviNjpwu8K6Cso5JN0GbTrrH65Ce8IiuKgWR8iCkBD161Z5hkueSA5i8OFv9u/wkw54Y2Dkah2YsoFh/m0hijXmDf/aXoLBa0RYdQB/YCErV479qdHhoS91s/jaiSqfCmB1YBdWIjkC7IT7xR1gQk00X+roGzqYEs3qCrxipXQsZPLPIvhPKvCK595U0S8vNVB649MYc7dbZPYv2l90ZFHBY06T19GZy8wZ8g8PzktCAjoqjuGI/seB2xqtzzx4UiHzf0mvXEizmUYL9hef7zNzZauLJ09T4sr8HVXdp3fSpun4NzWUtnsoXrzxWi9O8tf/lrHM66SLWqc2nczbU08MyKR9Jftliud0lZz68FDM0cXzMe7/RgSWzRTEThcZ7fJX1GlHFmIq2Er6gY9GhqT3KYI9bxPUF9DmbJ6j8XIAcTGI5G3iefkqqL13q4HcKW4sAspac2xmaZEvGWKmUykHmvacpIuIWoxaQi28AVltD6tpFK8xJPMRkya1GscHR089/ZuDRsRapI9Ctjw4f0qljEQAbiEjRhUf8aSstSNX+rp+krloZjglmZwzmLCRkWJ3HXtsJxAn8hFf5r50cAalIlmuFafYUsIO2fl+5hYajimTVXBJJ/thCIoUIGN7gE6KRgOoFELQjSf3SpfOZfDr2cCTWBp95ENoS3F0b6UTUM7d+MsByhgPnF8d9bTTZpDntVg5YBG//2Naso4dmtneso94LMtYLDeV5BywWx7idoct50OGwsbZqThXH9Kz+2ziHj9qm5xnawWTf6JXagtDJSM13fZqLIALlTCQmnWx2rDisUdFefLWKLzdQYV2GcbM07nx47vzLDXBPz47P1ovQyArxTR0n0ECpt8NZaFsxgFn0pIgmaI3RJLYUmjkhq4w0RlkyQSdIF4aMD0hLLUqQ3gwLkrcFCFzYxlC8rZkx1JLPWp9/c231uJfvZwQxAS/tvqWsTa2lTrdJORvBI8xcgL3nnsFx2415LWmBgnwmn5JWyrYcq9gdnTYYZtMngMLjTN0DFf3eZbg4HdPPmurWgEGu9hdGJ1XrfcpS6kf/Jbndp3LKzcP36eBWe/+SO0CdZIVPR8jyEwEQbnDEocuxHUJ/MS50dXSfaZyF2exJ1gCA7hGtlgWas1GZ16S61254pFfysVGiQS/KClKWpTjuM8SvCnF2pRofZ9Vm2enJD0bd4CJ333EP1b8yagwJ+yjdJWiPjynyvmPHTn8Ip0iuJmNjpOXM4guThYri2VoQV6nM6MXbWPdhhcsr1IMiXpVEerb+BO1ptpT0hk+dtgp9IsY2uTSoK1BmlsX9gDos451u5JbYjKXWEAObeg2HU4YVEBdxYnDMTuPT9ZPbQAI4g1O9XMTBAlHsgQvmYg+g0vfucpuWDkCy6dHnlq0k0ibvQJv4OL+inJ7+QB8/S+FfYtph+cE6vjmWiUhv/yRIFIYcIcS8IsgbJ+gXd5mLTXkaUGbKvUsD5JIzn0h0UWla+jS+HOZDtWdbP/tHP7FPEmWqOZyi1D+01fD44JjNxDXlWX90AxHgyp4XnY5Z3TFpxK2gieUBMAZOVgvHiMe14f0m2MBQ9VQeV+KUfdTPPlPPFaTMcE706HbFzHdkg0bsIKT0zS6HwSBJgOEmecb8cphKZwZFNZK0wner/I06Eyq8IrhEVA13i4BIabh+WU47LEwlEotZHHB+LIeal1aIfiFCrLuC5TxDJoSa6GJbSHjFQkyPcprPn4r6m4vfDyzkndrGfkZGri+GIEXkwmZa3Tr/gIa2xg5ulGLhdOUqiCurdn0AEzOn6HrVnZqBP7CEOtHWSBCLCXPPe9hd2USw3hg/9lV5OJkhyk3oIqEGwApBAciePN38RSbPOvdheASdr851cxx1HE2BaH/S0IDDjeZA9iT9xj1v1c22I+LmpZg8Z9kBOMmkLIIAYL6SE7DXZIuqgxNwrLJSBxR12XS2rmrFbr0yr9YNKSUjVp2+lWs48MBoI7P/tNIAHzVoFPxeXO9VBvvBQHJUNbvZHzysmrf4zdOm3a+jlMXIOQ168d3R8rtEPszcRqS7JVXVq1HFUvWEoq/Hqdl676598GDJ1DAVFU8YWti/wK0/MWFYnP7+5+Z+oli0IP3g49WM2mVseov93OGk42NBrPm8p7f6Tnt8zYz+VYpsC6mU2eGTiMV9/MZ7wgr6XzcdHvkjm8MW5GpCk0u2b0T5N/OBx1kg4K/jMDukbqe7g6KkCOrz4uz7SimhrcO/p/IIzVSAx7IJc1p/FFfPRWTIx1NdKDroBYWdwOaVDOlSHmxfaZ7uoPCQg7BWl98Qw1mLodeRJlnZ6RQ6wn/9EQvpTipjkE74SetthFkqcrF2nR4cfdlz6fxZ+FOqCqrR8oUGonR67ys0pzp2AAvrA4269FzzoDpRAdOw2WwWljxer/Ql15wt9XPoaYsHmCr0vhQk+wRvEJPzrsriVFSLZkLrr9B4nVJBb8TVtoeyLAwFCzYo4V2coAqlwU2FZH5Xt5NTXgM/PQvzofNPMxqQZQK87JzTE1MoA4wNtg0deVDeRzSd/TjqyyMasrUNS2yhy6HZ8nLFFiCq/Dz3gI+OYTxVPEsvCdsZcal5Jo5Bkv9Zy6oe7oh0yb4hfKS+zdy7WjWh64ywu7W22nK1r1/ECYqz/NVivJ+h7Egvi9wSC2PtmJCV+8gfTuCCGY/UdhjzhsxZVGoDxJANKnQa44IyVN/+gzCDD3DJCCPP9+IUND3wx5TKK8lWthn5eCZqiRAiztjLPeGcYFxMwoBha/o+X5cCWqCvs3UHgKs30vXcwYKE/gTjhZkfKVs5fteTWFtdgCM4F6tsMWXHwQdHtRBeSMFFvmsAXhlDFECkGm13GPJx7vzoDc4fZipXLIhWt6E5ZfD99HubUKDM37sZvS/3sfmyOBlTE7nxzb/C9XQPRA/e1KStq5YNUYDs7OC8GVK24Dxhxywdl27sP7BhUVoJCwyND/BCxdBmrAhrTdwtmokSiBEc5v7D42UVkdY4W9EW/cPQBdJwR5o8a+tv0+gLPd7guwh9dqutboOOZywgtkkfBcnpNdK/QFIRi0mlnaFUx4A+moV6DBnCSngg5e537mOL+iBqjQrj4m6SBarY2ccwtGQOlO3A7mu5A546YKZ2eTN9owSH7rE8jqTQHpqgcQ/baAzR6jwqBiWqewR2r9TcyeAUa4w1o58AVcJP3+83xOB+r96KOJehQG5acRf0+OQFfMz0U09m1FqRrMF13CxvzzivIV9BJlq88KBAD9s5pQDCOBHoKllrQm6h7omtIsyeImGqdtPCrwo2H86ozE21xZsP7Yvyd2GknSvlrWlyx98/0jGGx1YPQxjQdyx3EFaeaLs8ZjH8z3nw7q/cc7GYc5mByYoH2RzCmrhs9/sizHR0942ZhFpt3BdnNcCO7BCaCEMxVbVwLVgUWAJkwEn/p1ayL7GFKkvjFJP7NCknWIZbsZaHZygd1tYkguB7FDsmwJcCR3Z1GmcnG/78AJ5FV8IjXEvWYfLxdGHZb4NkekQTZb4IbQu/fEgIx0MP95hq4ZRlyl+xW/ZNUHleGYYA3aGdNf/eOwSQRxA7pt2svqZVq3rIGQ11PIcfOaKUxbt6ZDgywqfzzP2W6BtVtxsO272glIcyeyI2LvUTrMnl/Ll5S3Bo1TRZ9Uvut4IoWSeF5a47X8vIW3GztFDZbJS6o12Gx7t1Wz87xsWZuO1XuTrNq4Iw+EeJOVhGCpBlgf8hdudsHQj+xLC1W/cG/otvn5QljYojvixSMkIo/HzBXSOWaqiNbHQYmdTnu32RlcG0SZmrXNEufs/XYE2Paxf/88uMy29If/nmrVjUaE7bt2o7G8E5j/k/1u67M/QJBJKazeky/JvXYl/6BxsvpgRolmcLsFc7JVtxNo1ZWLcrO8+XUSdJf6B470FEqlASLpugniucZsrxstlH23Y2GMcGf3D4Fzt+Z31/53l9qC3bLFiJiocmKWkWUCfmGBEkmTJoPCLbptsCDvgSz8yhWturh0FwMDXGsyv1kwXzh4g5+obYDozHVX7YfNfgLUlNjdyjbS41fVAMjvDsGaruTtuDGhfDYV+zhDvDsCmXqxTsSWcruY/c3PV3wSY2aRFlklIPVj8C0ZYAbfKzPEOXyLxWrH3AQlrqfe63yfCtEjTGS5uShFBKEq0VptUuJyy9LPrRseq7ut6raZ8BNP1kt/rcuy8TrtSHYfxQtyOm0y3SoSXm+dIY+cMJ10Pty8eCOvqXNpXhVUSjnA+lO8U7Uj2gvsXdk43aIcnIhkXePt1vrg8DLr/MdT/7fpuzxqEBEVCdc0pWJH9j5/kgOM4pLRLG+Z3B/gj6p3mYOu67U02mSOAtNRafAgTymZFW8Cf/Gb97FmzjIzx1ENpF07S5cCU/WA8vOYLVIDqB6Rk6AOjhHaM4TLZScFl3Bnat7gTkHHA4otxPMAdOIzUtGGT5Spd1RSEo5XiuOZ0eCH/Kmh9tV3/CUaC4z6hzMDFufaUvF2AHLrwIhIb2Tdil7Sji26WaKz8QobKRkDdPy77C5TFoZE/HZQS51+d6E4B0gH2m3DdHPLjhj6FYCPfGcEJenjTeFP5dXNjZBPe/NoK7yr8GsvGsCDIe3E6WuBGNX6/UtahgJ5UT53QwHWXLMkoEHEGRfhTvRu4bWtW7XQNRyKpGWeRPK8q72sNWzU5+hM5nXKVpymyIS7QNuZ71yr5QEvxwufjnsbNm9lf332u0j69jz38X3c4jUdRHbJBZ7IK7AW+W3jfb04OMtR1dD99WltdkgA2G42JufPwc1A3PGt5Mtf0gk+F2N8PG4TGJ0NJ246sbCRH8Ko5WKDeiSb7jh6iH47YKXuiCfIstahYVWa8dEFxNTCPrQEJKMxWNV9k27uNj9qnoBCJsRLz17ZUbu+GO/fo7f2mWM1dO+1WcnogHEyApL/KCzUzoagohZT/X7Ap1nzvJENUBEMYMU5j9K0Qc0V8K/rkkwVGSKGa5lOgw9aOEK7myvRXkMS1sKsfOOfogGUA6GInQDw4VUYsLBKeXA4FzZkBlKHjzZPfGzmHpPXgbTav7F4LZLU19jcrAPJ5mGMRX93EXK/Ty1cMnLbVBdgV0EZ8htCoT3FSfFQafHMZiWGvlRaAOag8JnnfYeiQVGmrEB/YRYscR7gHOhLanSrvcHeukNjhctkj8bXmcJPEWWXmdRQmUVi5PAK+Zv1JwLg9jCg8pM/3zEvJMofnHE8pZlBIlZbm+km4NDtD5GHU8oOveMssUWXkCjhqaoUISAiiEYJlVH40VcY80C6D8VtWzQuTtwJ5Ljv4E3JnvUt5o3G0KNWRJZQWFNebMF3wB/LojN8WHpHYEHrjQUDveI3qhFpjfvC8UoaTgTaDMTeTY2j0TQDOEp5iAJuGfmdIibfgyLFGJa0tW2uv7pv+OcNs+U6m2ZE9B5j8/mECAd18GSzNcH0OJ4yFqH5HJa0CN/HYcnm7EKfAD9Ug/iKyWEg2H4HVncLv6x55NLvM6jXeiT98GUlk77MEh/mg6AACoOTTgQTfO+J8T22uYFN0jo5YpMYmh0RJnCz8AgkGPt1dW3dIHyBvPP4Gx7FocqBMT2UsW0bQGMQC9b6qaF1cn15NuskLsWw/RFXIe+CHHgvZ6K92j0KtzFrvXwiyWwb6Jt9+U6sczgF3KEUevJ4G0oEqIGvGc+NmMI1Gmhpvf0uKVYgDOK9R7wlQqaMoFZkUq4DwF5WL1Sni7UlgehkmiMuMG4tIidTJ8kwQkzMtpLVcNJ5K9IywJQqlijOa+PZL3+y1iTwyU9LcX+KN/2j/bNbJPrpQUQtoEAxg6dSllXEJHVQKe32V4FfGz+rU0Ifrqsh/ZmH0jRIsdxkCTqZoY1IbWoK5R58eI/gL4fsz3FwSzQ0OveiwWTinmHuJeLm0Y7E4VpBBp7gqKWV0PMH2qnzMvKZpwwCxE768/qCIxhbqsUM3ng+pdNdoCq33XAAJ6QDLkT7yL203a5azR18PBIJgrkSj5Cq3mvDxiwgU/8xWZeL1ETes/DHya3WABjsXgZNLWiTiNtZ5RHJ//roLXfTFR3cb9zO0k9cyHzPJ4az0zErofFmD6rVOA7a8Kh7piDCyXACsIQEUHJSNK6tsubFQXUk3Kbci1rU/NmV5ptPooJwiH8kzf1OL+1yFIakN+uM6T/e27e+YiYt+7ewQuZmuj4KgWV2v+w/3cVt6wmw95vQrkKjEJJ7HLieJ0xzljvrLfs5WSeOB2Gw1yu1z55Wjg6u8jiAXTCRhKXnR5UO1rexlLSerZwwq0c4MOljK0CFg6RBapps8LXU4PeAZwxctGKOzFvP3rIXzwIKjQu63xaBlQK+dKOv7D0n9UaoGm+iMQwNGcllAirb/YYN3Ky1zyVZOJnTFAMv1y+ni/xHANmmGRO3VNK+yi9Mz2sunGtvndVun/2H5yyxtmdkZlqAetSaI4YKaXVVJZYPYpQ80DQqH4fRWSxPrjdOLqcLI6av9kwO71khJNbtNXcPaoXh3h8ALX8P09U7fN0psDw1m47JdL9lcKPCpB9DcL2r9OkgNQbBHYGVJNWrAnFW+3zMyg5gDY0hwFgcqwFjI7GCwLvMIkOZRojcS37pdaButYSYLFhVBqeOE5ZCtn/tHDENayPFBrxLsuto6O7+ac4ZpaN15TV1Ay/bMq/ARDWxsDg2v+2Gxk6eTBvnB425Ha8i6/6P6fm69B/789ETyPZ/vlUJXMWULo10bMrh6IdSChncz5/m/0UpHWl6EEc6BK8kfxqzqpeNZi5+PYLJqCCvSMCrXFML/2xXZphrswxV6KaRI0+cCUGV2gUSFsKZXLsDCl/NI9Z5pCmdZoGMLPLVyx4vwF/Z3R7gefL5zdr+xpMp2pOQj2/91nWUvaRyRqS5lNyEigaMB7oronYiyv8lqdu5Ev2BSnFlNXgJWRsoznMWuBdhpSHdjbDMxVdrTpr9LrVYhCJyRLE113jHZDGFFsEK49+q7/G0iJqyoJx2j8yuVdk6slRI/TJp7cGIdbrpSu+IaRL+JmFvJ40fN9SBgLm2Tns5bxTmCv5YsbR1OKr/mPcEIGX1+YQmg277sav6Z/kNFWJzNqhU22poWJKYP77DuA4ZYC4ay0U6TCwlLMnoZ6rec51KPgi+YwIzksTZSwvbxyOJsv7I8LOgpNuyCiVr+0/RAzd2RaWOZrXz4PBRTJ38AButjWZ2VgCp1ZzZl/svEM5bSLGNyQ7Maop8gC7jrVFAflEMwCxOVNhyaCIVYWopbI43BrgjdJOiHvsOq0Jx0qLgKlYG1xrxEIlWr1vMCuYce+3TM2B388/OIZR7uk411nMjaObJY9Sk/zFp7G32+juzSY+pKzYisuOqM7pOzdJCPVhUdjL6E/4I3pzQ02xoVZYnC5R9U7Gwnr8TK7aV0CSjFObL9PQ0JVqK4+IG6peQNZieuRH2OVIZTWRxNBLvfncfo4GNsJceRL05KWWoJK7rAQbKCC2BX3MKZVy+T1WJh97p2wwvsDX2GaL8B1YfDnUZDbKChzmpFEFtZ+Occ1EdudvlTlujalfu3MKKzizmIzQVbf+EtgLF6H2hTBw7LlWrOZkQBqgX155tGAkI3cZK4QD2gfZZzhhFb+OcYtugUUZ6DTcc6pvem8z7JGpf/kbtlkKOI9D3GGdJLxLJSfL4Hq3A5rgTdyibBkpXN08uzv03bPxP+5SASaK2jKbDuVwfVPsP+TD2LwC0dFFIwqsWfKJH7XqTCblkpIsy3gA7DRF/x3UaXsVrAb1JACjGML9Rz1pMQj+k184O0438ytYFWV38jWTvFtvaOk74D4b8jrlHvhN9XFgMxEaNYd0mk7rxG256SADxZR73zK2ZWBmTX3j+VK1BKsGfCSIPZ1k99jQP1xcqqs1yWB3i3/bwNVCsf1shi+QYjkHYonf8ARb4CDbRiS9T48/XULXbjrJPN3obf+6pN5h54Ypmlt0cXM8H8708d6afzXMCGzJKZ06/Z9bokxt8JFBQXa3B26QdPSlp6/qv6V0Xv+tlhV35CtoTJepR2empseZgZ7YHR0Vjlu0WOfcgVf9nRt6qZJUFm/OjSb5G8i8/DQlE1xY9uz5CmrYerpp4jHgcN7PILJSnKmiYsnCb26TmPVPucBk8yqqAflODJexn4L8xfxWctgZh6AKAu+LDU3z2aDin5sWoIImpPaUFV8X6ZWCNTw3TqBXsmk2+etp28eqWmtcRrS4B8PuQrGBfpKeE8CepDI0TuIC0OFh5H+eGhRwJYmyCwK5NX18Kb5E5bg4bHUO1O37x6S3GNoQ+i6mNjU0jzW0vN4OGMWjuxl1mpF+ebdFdfei/XszT0tbyaxTlQIkHib1TkXZthQLRCKmA6+mDvRxh9UYmyRM8AFG8gI3nr5sfbLXd3Pkr+MinwgQRUhQwBx1UQY3EyqT08sJ5F1efLFBTQgoZlpPPO8OfC+KPadtgZb845tMMcTdRUGBBHklAIoYtQ467icZgzpCg4WIdK5szegJCnBRzkSz0k7fB+C3FWtZy3rBymfp9x8PKwBhjFGYq6vdV25bkjy/hqV8p/viUWh/wmyLF7iB0EfKyk79A/QjSW6IkFpHs9mzdK0fOdmlCPMKMPzmPHTEq4KPpeqEGmST9alqWwdRWZbmAu4A/qRT+lqh02B6p/kkdXih59+LI/l/yvPD3EmnLgo1St7/3B/NJ/MPc4dMio9dT6lDw0SGNViFDpUF3EzRnMxhCWAVTSSoiddJf4fgnBc4RZYbjcl4VyeeZW8LHAQdoAJwHoaAhCjTmvI/cVhWFdw1bwidvKIPSIhdikK5bmeEWAlJFLYNi+SzgMk0g6J2IpOjC6BedEg4JqG0N35+TyfkS5wTy2idC6ckIl1kdN1cLCeJpqZV6BxS+W1xVSsHcXtfAO2gHlTNotJNd9xLB9GJYdpgByJV1E0afWJk1h5YNm60Ti/vRsLJ04WWuaQO5bYThgqo/ZTMc0hOfCSUAFdn3rTJRkVdjebxBzbZyIkMkojx+CtVK+JjZXIbbYhlcoMEW1OyijOOXogfgiv7CeeFf7yMK6C17Sm8ltJZldvueu1kTO8EgiHlGAhwUAd5EV0j7cl69hWMCFGGnSlgeIUW/RTRJoT53ObNGucOt/M1O8wA5c2C/r9aAdyOHvBYVJOYVswMAkMRSjXoePDIcrjdD1tpRL3mo5n1jhYROq/vnsAd8xG3qgeVJLcwkDmHVQ3msdi9kHFHUzV70zkVGkdm7/BrA/9iNzrz85e+/HS0MPvoelEHvftjAEVmYnUuCxQtjYsPBvxyiW2E8aKXEFP9s6fryRmyvLeyD88z7xux96hv7pTPxlIqaL1alnKBYwozGNW7UwE+yPimWowdYiFu9gjvlNJNUwBtjAfYLJdcSYPJhCQ+DLcIwWssOVb4r2in3l94/Dh6R/P8yT8F2FYC0IWjsyxs5JCTS1FX4omZmpB1++G25o5G+uTvKkX3pg+Ginetq4Zbj77F3uVagKXhX0T77TARnvIzHT8J4A/t+13D8aujr6B09vDtfpaNm6LnWzTn7g5pTOJDLIsc4MeTRVTQ5pPWZw4ZW5IQn0hEmtK/X9PrRBNkN5ULG9Ez4/DJBNWyrmNluiEDIChdR6ycJalwT+9te0wetXCfcZhbD3Z9LfhZJDfYBRnNFQQx5Pm+eUD1zhkNtPPt+SLNobjwbUqYUwUqf6CPxrrorpzE8NMGweUwm2MEKGiKefw/qrNNfTApO1PBRaWjSOEksaAg6mrzj+h6pQPWy2t/PrbYHU2aqNqiFKUJSOuxejDfbNHJiLujppqS+KIbQnG1Jauqmi5bTncPURtmMs6V8omHE8ovx9IK7XV0JBJcSmHvvBRhfbIAWZdfdYeQP9dzzalAaFN0TWaakyAIyO/MrjegTW41PPR6sCHF9EJt0gEQIp1MsH5k/UK2gxFEVH1COJvwQgWoJwrS5IlV1H758PQ00PviKliYXd+nWs+3JT3pqxAoiPMgwOje8uaHP+1ngwsAgZaMvVafckQ2+MuzuQIJ42brxVmy5zG5Cmg3/0Tdhy8V0p1vhGkyxggb7AahO9wbsoXh+UUp0IBeNE3RHaJP/1o/j+SIgEnxctCCht1lde3jCBe+2+pOD1wE3fGQdnmSW/SnIxblCVTENnEIhveVAu9hAADZBREa6B/ug7dBW+SZu8E1ib1OSnzBOlDC3PLKOcOEoJn8M2vRa1EintCACCGghh5SxrAevWe23rtwniWSRYdg6HjiDsSJGu2bRxtDoTU3tM9KoBEudUSijpnOzucySyKJJY+jeZFdqW4y0AZGcgL9502U/KBTdR5X8QmJHpxkAlNH9t9kGxxF0w+L+MZ+NKPozw8v+1oVJnUrJnaGuZgvI3Wm2uy01vZx1eiX1gXnXofmX0a5lF0/m7RdYqU401E1JklZDAi59uB7I1gQubK8yhIXTku5TOx/QjzJrdx4LWvMvLpkPxLcIINa2WjWdPztv4ZMdZuBOfHLgjp8+8Hr7KsRYJ5CEJDO5U+aSlloShf3JKpDG1Za0DYa1ZKrKKltTu6JPpVVNVzP90D+Vz/IIMuLZBLTMi9zcRGQtZ4/nr2WdNHEzL6g3+m+RZkCEbw8x1mqgkob4dGxKqgZJgtjBc3t+ZwT5ys6/Y2r2fzLmmLVSp25ouW/dmzDEsAKOWPQQUv03o+rcOmFRh5SMmJ0v32lwijx6ckJF/UhH+HjKwxChU4xYDBcgcyJnLUuWE2ItZmjzJGbK7o3j7pn3OLhYhelPUpUHJBmckODImIOHVXYmoArD4Od13i+EuFzueXTNCNO5W2lH9XLLcyEKalgkZyVvkdDxGgrnPXKRFkMDtPHvQPi5x95yqAsuB32pUi4qP4DZclZSwHn0OtQW+H+izEaz+kJC34lqWh6jnOI4Ti2LgFhyLXVIHg1e1rfwQVv7KrWBzevsT3el3a3i8bf+HB0q197spNlHFALj8gJ3v52yzgjbjJXep1fzrZiJSrOWOzXa5b0sritMg1kM6Pl5Pd50AbBGstDLhxLZdgnP928mb7i4pLXjop0I5Nygeve9pNaHHqyVnVxdWpg1UFQXva+0K63dVqZNJaUvttx34+nVNiVi6WkJvCoXDplW5bs1dwAIYkpw/jTlzWJ1vYEneXBko3I+nYZUu0rs4Kig8xZSBGjMq+SrmUlZk2b6m1Dz5miReulSTaGE1qcv6SnFgcu9t7O1rcHdRxvZ795WV4flXETIAxJ27Ha6GRvJxK91XGt8b0KAhIt9WOxXRPzMmdAs0fjIIouKu00CNGKclVDdtHuq2NAEX0o3LuzcWDTWdzqYL0SctoMxEfwfAWs4Hkxabe38A6s7dRsTTyNJrxUOwnnrFdynU/cR24rZBmrFaPyOL+X9fdpzypRc15dv4s0g4fUuAJGfw3nkkn8qzwLBprposCkdOll+l9xN22Dz/SAcVgUG+grJ8Mcyv7aIgyPd4B1caSMdhGdHASeMwmOMAz/DCgYzW7jczawguXZE1l2FD7i4mIq+FAju5xZr1+wX/Ju0nizeELXSrpsXyvmHrIkUXhsSq8tnF9N5/QA2AOJRjbl1MnpwiCE+3Uf8lcYxNmx6rHOqIdHVcs8pDIULcKgVPSK4ZD8tpTIJfPN6/MW0SBqs8xy64rRrCQUwYOPOj+K2HnzB8w6ITlqh7tfb9w8A8vsSUhqXFdwmifeSAw/wI+x6CDNPP8qC/vQg5vL3INJTo+1OWB4jVpkO5ZyjmDtFcyfLnBS58NfqZc7v7es4C2feywu8Qyku0Vdn1L8VOtS9uTqVWHJxFR1FF87G1Wx8+RzhWyfpjnsA5T6KhblZ9mn/FmUJS0ex1YlidFhsMl9kVhoLbIicIoHOMfwFhfUtzoJK8dmzR6H7eVGICAOlAyOip8WONGAlYZ/AWn/3ze7HS+4kBd5NZXq5EsHSUlhQJxSTFQLiLLaLXhVqbfHYMno+d4Oz67ANHJ1eym+bXhGtlZs6yqpfiP+f9qJmMmYXST/w2jT6ZFzj5x5BeY18y6c9khmYijVZhZtUz+7VEGhdXz/Zf5p7Oqz3fIwxmP4gvB0WfKmj3R7hmzy8I17vuSoNxSxJtcmVlAFiskaW4w9rXhUkEMoeSqL9h3ZF3jXVMHqCm6RBI4u6uK94dcYCw0b8VgAIXrq1NieZmtkKVjT8IBKOTi1ah5epzjzeroKVz8DhD4EpTx38nC5jQr0F4Ps70XA5LLSUWVtmrItxmVRZ6z+12r4WqPjWwackvV7u3msbQqhi+ZbuVXj9XaWykfLJ4hyLOhWEbzIeLZ3z5rwwF1NCrF3pYPhUQiRWr4HFqtU6pL1e2T14nc0LLZIkPyXfl4AJ8HiL/jY5L7ZpRVLFNn20VUM69V63duHcpSAwd2VzA1qRYbzerqP+C38vjJo5S6YouiNUgMMtXLTPMxOAjLh97UZDj2+pA7bi+n1tZWTVbaFKSJki7GiG2h4CX7+3dBoF7O1Kh1tRVGj96bbWAPidi5c9JQbK1xWlJkWzAiay9kP2Ey19fUE6swWJd/JPKJbVO6bI1f3V7IsDQMDiBcwcdlKMqpyjmw3yqBKJcXccVsEjrNapnnXmcUOUjGRkj2A+KAaDvDgzAQqV7j8UMccI9lllxRncySfxLmZ3SYt5F2N8QK+Rp7h/cG+/Kx5MDE45gAB8/NVSwGkRpkR0AzpcKct+uMNyq3tvQjnGarCBJi6uuCX1j4rIHvSKLwn9n5JwlAAsXcDHQMZlAH26MqPX6cFlicBBDPunUypq2vbHNgqkkqmUKXnfe0q/cyEUephBlkdBmY98EjmrLZCUshsrLKWs6WL/newy4TlbacLapQKvcGTZ4RQo6vK6c7QmErByhuyvzOTs99FvEUVRDAas+zhyZ8rPZXxRCO5kSA7a/eYdGVBerfeL7I3h5D1u0UxxMY9sVgRBm56QvvJ3Al6ets2TwhQwzEC5x+rJ3cS2wwM9dwTaVQ/dsE6nxZl7Ny+0S3mY4PaDt/oqJ8thhuyc0Tp9fn/2aONrjcIyGsyDNCvfIW1NoMXJgWYHC8AOdhSQ1M0lMYAxlpExU0KVg9j9pRY9b5wKF0nqHlWcrAXskJBR//nZXELqOkYpgp1pPxZFySuAEScyG3O9kI27OzhNeG0tdJ6WNOM5sfEhTOXcqNBFS8/cZPJofrQzoyssy9qauP5R7Ub9rkozGAIUgr62fbeegyKaWww8ZUVbl3cRmMCbNYPDUkzl9nDP+Ypjx8fpRSp10hRg9OocPIvNrBT15uVaz7kV9cwJxiiVXSUJGQOGzMGsgCcxibeMaB2CcgRsUGjeyQvUGz+8CnaMbo1CfuurSHy2NBZVcZBS4u+WrKPvkyL6I/88t+HRffwdz/kHbm9OLbvuHt8cWePQS/mBEj3RPDWwybs29L7p55B7CivH9zD/JqOqWKYkbwiXyORytpddeHSOeEMeVs1KCPCi8tCiYvRWmrr1zg5xtUaNZ7PWMSg3arbCeZ8KtShOOxfbsRb+SKMPcOQBwlAPiMEXv51obnZOPmWPm4pUsKV2dpHPbyVPVVHGtkZUdqJDu5BzbEGeXfY6QJuWEb844ZTEmF7wif5U4/pw5HUsjlacrphl0xtZWJSdVREDyAztZBeA48Gt3LzSjWFtlsfYDE1zaGYDCIANxCdcbsmT92P4l+rq7o6eKNlcSd6tEnLHI7aUV8tQ0ROYACaOQf25IiTrG7VNli6rzzwwYoigztUmcQkkSCkK6NcdrN8JLTx1u/Z37KlWZXIRE1Rj88gI0CedB+0WQs7oyv8S7PkQMV2N3lVWTN1bNSnF14hL6YDJzmL3BfI6DoQVMB9lc1K4AuLF6bQ+Ssu0GOhgW1BIHn1pGQbB4MlT9teUIAz9NBbivLRkoAWa7Oz2V6atr3JJAXVxAfivA3Gh8X+sMggohYRQKKJLdJbLzn7SGOy2rJ+uwFwGhCd9g+8F7aiIlrSOe20MWX+LEeJIos5PLY5kGwX5LA09TCPNifslzdXi8LC+AeSg0vBQHuZBaXyB4C9/JHlL63d/fmyc+P+Dtd2IKQd8AP8t3z2nQYtP30bLCfBYyh9WRhYZnQvUBfm8ynQzU1FGiCjoEKffbrAGVZA/KM8NVMk7OSGhjYEUuKEjCcjZuOSCc1DV0a1oQJnJ+8QQYiss3p2uyGCaySx16cMfkMbmZ21Lkd2OWdfsZL1Hyh2O9xTOtT3dkkl1/8yTcltM7i9NGuP9gcW6P2aFhh71sQVcOGW7niY7+JaTdM7r6JkkJ1+ekkjdGmrdQ9xl0TzkDuC07+lRB2JElkfxAJEjcRRxr042xdH/8V07IndCj4URACNh9GXf0vsilPsgQJHzPpi4paGgOw0nQ3zuqj0H/4253E8Kdzwxosd8Anp1ZPXyPtRhW+qgyKjeF+MFapvwrxKZndl186CULHhy/qQifDRKq/EgZKuaLvQkXpIQzjWMss8S5Ld+K+laAfl9uHR1Mwsz3BhVN8EpLeoDkQ6VeVX/ZfvXvuzc5Uq/1fVJ3tF218+QC6Mbaeg3gS2BGWsZ1eY1PN+ffxkqR02/F5ZsjrnJfI6azM5KCm4dSCWfD+uffD6nHyfcGFEZTOKTHUrstE3yzVAUDE/koC9+5W8k7UFagz49ONgscdK11jMzd14fc2nNXnHkZhCJmj0JE5VxjQG/G7HmGN11b4n+FOH/X0MmVLtwvGgnvf1nyjKPa0Md/FMgEn79eFPFR1xUNEZFkwdvSpoimzEmRWvVPcl/sCVFCWL/Wz6LSZr6hINhUCwwZbgBzdVqjwRYbmBpYh+iF4TsnLV90qvaWjw5PLsETOEZVOCRHtzxXSrSZ1CjfYOymIPdOejOS+Ls+nop91MX3Xdq7uxplc2+sxk7FL6HdjvoNe3iIAzyVPmwJs84NOHKVtzExUXlXKJEDALnJtT1Taqv73Qd9HGEp0x2rr5IZgLOXl4FBX6LIiwhICnaTjKrc3ywLjnT4SWqagVnr/sxMsMVi2lUlnzGR2FguLIVRbolp2Rrub3Wenx/GSAy0uNJawSqzGp13ejtJrMiMxCmOtLp3lKNWiOJTRWiBqv4hmMsBbElIj//iAt2+Fi3m4UnkyG1+DtuJ8y9BWdQ+oUYxGDcFDQGbILeH97KAjt2/9Q6+OEubvalj5Hl4Cn0k2PnUVwcX4V8LBBFO5ky9f1cDGC97RahZdU+w7vgusZ7R7K47TLKniSAueOPgRPkQ5D8lHye3H5LornQxWQNTjVQuc5Z4667d3Tm+seeq0AiHh4zNfQowXzRjMVmbeG96WO9r92ecGWv5LrZgGy8ia/LNvIkqkdyzHOvgRUPBIkwlIjYVferI/W1kGFIKeDvc1xSc5XbDYPjQullz7itJQb0wDvsPH3eJ36Ns9+TWQrCpgK8Teybr6mKBApXZNDTrncszAFwNFYxZSbL+wQy/BAj3OfmfbYMKDtV1l+pL5WC7iSfwdGrmRmUnk9EAyd25SWtqUM0T6P7mgeDxHoBrL9bGzZWuBgcRezLACJXkqF1KUXprT4vYRfhDNud+2P/k/zsWZptm1CGe0Q+X/TZCr24A5a+og0iQAaR0+YTyrkcuxqO8fVtoJdyOAuM+IillkgRijQ3uWDkFyYLV3Caz5AgXCPJK/ehuPmiJy9Jlt0XqVmbq28J8ldEQFgAZdCfttygLpVyjmRE2Oisvf3xAw5n/69smbvqk0O0kB/0QTLwAozdQXvCmNEwZmAghPgV8zIVCKKe0bv8ckfcIQ2g1PYB8HrlldiucWxvZ4jzm0soyeXLbOb01A/mcuco5SoG07UQwkTwdTlFkyQ17I8LkAPUeIZoA6U1TdLAs+5E5cwrNNZnRPuS6d/WxgPAj2AapphEzCY2gDiCBw5S2yNPY+oyHghQtprmWtyTDPjXSo1xmUlI3/sAH1kZSVT6dAlryFAx66ixvhtUIPnYR2o2GbmS/IwYPakVxPJiw8eGsjxrwsDLH7Vhuw7ejfSmF2U5tAM4/MNmBYPmzEKhGzuwcBoL1pYaNbic75CcFo+KvDS+PGfgdnwgKKhW37SG00V8bRX/K2I74XChpDt7Jr5QYJkqdxsMKIkyWA8WRSVUP7Sa9a1K8ZNJos1lD2a0sRWrOmN0OVUTXVdLVs5Pr15693wHlfI9Wpl4j8EZDhmt+TOWY+LDnEyDIYUanRF1WdWuzGNYIAz4VcaE78jZgI4ADw7kkDAA54paRdrZexsoBC1cCrjMEg73OiQSPVG54jjVcZuVlettQkeUH6AsyadG0DpvNauRGDN/UrsQSR+3QDEzYO7nV8RV/cAMLzRa38bEUk6SFa+zLLpE87zpYLFtCDD48doEcbTL73FjMnp+KXZgxz3dWzmwoNfyDxz18DTCGQQU0fCZWBnf/o52CMWb3WNe1PzCkZSL6+gmBR5P3bRjGnHTUGxZ17hgvlMupPs7YYI3tU8Py3vTAQ6b+Y/7NN2quunypJYdv3IBTJWw+yJ6o5oo3kxjKRx/T+/SIvlyokcdotG1OKlJ8+xJ1Q5PjVE6p4nt2M5IiOQiGjebEWMN8bz1l4sGlg2d75+zQ8cyRWEWk4iBS4kjSnK0z95SL/akr4IZHDqaCKm+Mi5OmB123CBSfiGVYQTvrjVOinEJgDlMc8qCftAjvt7w9UgukcQhYIA7XkH2VTnTJRcb3aosEMV7MYxRw/CCnWPmMyp4M8lg0JoHw7VALpZW3xBxSaH4wnb43JRwguKsed4W2EzPDuBBDDc2cGs72DDyLau01HgocVHi2NPzjOFVU2g3qPzTnetWkbv2TUTdqvMgxFn9JG/Vd/geEORLJQhpiHI1YcsSVWS2zsNFpbT26NtBVM7ZkwjuX0XeCUtjRyMp4zQQ61uciKR4YP6eJ+AYeQXFmy8wXRAILd+y4xP3jJm8584Zk0bYm5EbHMMFN00Ro1a0OhmzlFsz4p+IuhVCxxFi8lbBzSef7S9A0RDMiwoTtUYdy8RFwJj6NnHMgtJ6ialHwDNpdeNGprJLqvQZ9bBmNOgR8Tw1fP2radBHxNTteKnhWePvA5e1IFn9iT2zC1W5WeriLdWIuC8WO98aBpNueNflI7wtwIc5N8lhPN56zZQOBzlYZ50m1Fs/8s3MLse5KF4fggnygDUnGVYgWhXi/iGkfLZlrbCU1dCC1oN34CRlGXLA/C0TzmPNhsyMprd7gCtAvf/zIShNAAq7uEurSRrjAz5CtdfFaijXY1P0C2aXKS8zvVG3E2b7SvwT4bJohDN11YjZIvKYkgEOnND4bPu6MeqUSBoXKHAxIfN2PWkU33vNOG/GlLKaAd9q75xMRx5eMMAVsf0R8HbAWG5t3RdJPWlCs0NFXVhVcKxlSEXPUyJ3XjpS3odAuqx1TGafn5bssqVm+lVqPqMe2SPLsAjsi4h5q83oBMkJko8sg0jzZw4/Bis0Qb+GTCaJotV1gExmvwh4RCfCGexR3lBeY2Dm2R2aru0BAvqYTeBMxiEe4xpxWv+evPoEr6RQu66nJ+99i3qPQM8wJEdC1nbd3q7ywSWdGCxpGjx192C8NN2xSl9/aEFZkR0s1YKV5jgSRur+/fxmMkn/f/SqS8jPUjw5Altq+0rJvGBqodZZBjPpTf0Wlzplu/PVsUa8qTT0281HB83cUprYTaxgAFhecQtEpqrXsDxjzA4z5is3VWwUIrXJfXx0iJNjJCvCl3Hr0WRMMrT3/XuRygHb/IwY7LjSxBQLI6GSw/QnaicUE07fNeDTVlnrYwnqRO/tPzBni27v/3JOhLlG4xvX1C3Pn/N793zNp/YZl10M6iW6cnDkbnGeKnDLabdZNVrR/lKgwvLYusZo7VYrifJNuIMb4pW/YDwu4fAEKuzl1yFZi3pWPQnFqfQTuiJYgnNlZAL6kBElNnfXjemmED+VQktvwxrQe4gmhQevbTPmoQ2B8O601htZ2sQobZ9sRt28Lh53xjyOLc7QSs/yzSUEM4zzL63NI6ck4V+kMFFRl3JvzmUcpZ9YmEnF3zcc7sG/UAuYIPFjaYRMWnO2SJKfgrIlVHlVhGO8VlP17sJIu0pU+PvUNYzQZeqE7aOic+iIs0vyuQXsBj4oug3rvjLRKbjfcJIkQZvgnhnMbfZHrlcLrO5jXG8uYxl0aESuyJxRXxqcLnj8Gq2/QMwiwP9TaHl6rIY+Dbt7hRS3bQ3ifNXbx5VoxAC0iou0QguX3EEfOWlM4Bwe8LjBlfOohNsKEgk5pkzleGvykDw+o4sVNhSeDSthWNjk3JJXzewNuk3KR3GHm6Ca5xrSR1H+3fmQMNbEHIUgmgQ/BCoa/J3fKDGw1GWtEgCGHaxwP4Gr3RrJHiUEeuxofEFVWmo9nolmn/I9uLas1kfjeFzjAwWTW4IuKwXegFxVQlXtEW/GpSGuITj+Y/G5OAepijOBPirr01sIwLhm+JkyP5oPxHQXkHt69NJsDJ2q1K8HegEcfAZ2YljMRVH30iMNCs7EwxCG7B72upDNlOHEFg9zv3Ls3Xio/9CxU9p5t4VkhCcpgU/Uo5FzLsA5VVKfj05IagL3SXzYaaHWyjjX5z9Th49w5skXYK5yR1QENOIAII/maHzKD3XX/7NkBR2o1L0s4h09TZHZFJ8jkyNG00E9IDRrgbwFxyb7z5Qhh6NPjgNjZH4Fclx8JyxwiKQx3qvEluLnhC1cBJWZDpHNbJvChlKi1u8rstWTqE4q5kmlInGlfmIthOWu5Gyvw6xwWUK9ijCKe3uw2FnkZ0+ONjWsn3YzKnoxAcrCuyP0y5pVfWmUbcvDO9q4lcCP3Tcqt9McJN37goAdtrVEy8WPz3lNdOPzluENqin9+2W8il5rkUqj+JWxyF18g/OmrJS6swyaEBhhkq/757h1R88+GKdmgNscS1ZGVBsiFoNSjwGahJnRCqb0MNKG+MygbyB5pOXzEg1h3vxFZbsvi/xPzOUTnTTMY35kWoU1TLYT9hrs0Nts0v5EyCDNocxl2xUdzQa52ji6DVSJzr9onzLLhdTKh/cO/8QjtWgmVYEn6GA35KMDJA0eT340uBmS+JNtKSOSHmoYmo8CB4PG21ZVCmdTs3PBTym8SbsaozMdse+h6iH/T8Jo+Jopss0W3B96lFpN0TiG9KG56F6jZZ2GtbhWCF3R/AQj9KwicTpCYNdLR95AMI069DzrbH/iAWOjbpzfYaMqm+ZACaXBphAnyxCj9uqguvHqOv+K/JsLk184BjfMDzGxp41dFFquSZa/UQRTM3T+MJ1Z2NLXwb/jN2DLy+/kBOzWSMxAATriYKcHCjPm0zsleJM5O9/3keuc4aP6uWyAbzZyFNGPy7CebCszdTToAWQdVnWwhxfxrUWqQVo73ZOPpeDMIscKPqkqCTUGzXczD1YuUx/Ks+KLQJmO8deTDCLHr74VJ8jc16z1t4VWMzO3f/3yMqP+qbs4KYbJAHI0Vl5QifcGeVUNcH4np+RJtvlXN6hzSSpYw7KAmRkkhZKWAtrrnlTa4OFqnMcJ/Fh1c0fsJ5x9zOUZTuAmJFWI4/WbJqzLeNFytadNq7oq00VQGOFU78VsUIzJngJfJbl7aBVFy5c2EnIYgqCxVuLNkE0U4iCSVtLUDcaDyM6sXrZrYe/5YiR89d6akHh4EyFnrI9NcR+z8GwkaTOsu1EWRW6u0P+g1K88PsIPSU2B/jNeOMFusveCDAd2ejH/TbEZqmRajxd+fdCqsTW1ENE8ID4P7d0v0YDQSXNMq7ZK2sryg59BIS2tUTgc9ZLjr8PrwfhQ4WI30sFh9A3lacGOqgWhPtMyEyiBNy9rpAXju9igXYNRwQjrVQRbO4H4QzWYCDmgQxDPTv4BKy/JKtwUvg3Ij03aLeXKBlISWfFXgFZLTO6QIW0neyD2u5ce9g86kHlQ/RM/5JBubmUJ/DQy09B6XR7gsvjj8Bq6ZQe9dPDgkUiPA6CDxpUqRelcIa+zeOjdX0O5oCDt+AuHT7aMrXhPwx7zWXEjs9DbOSom/K8/UipA4pH/IVxjiarF2M7KlgrL+ozsAcjPQ61PoH3fjHBzleC3OytyQekJlkQU/eh1JvFzWoUQwhEDoC997eyrAVbGumNjp69t3PWuA1F8zgHI0P3VVr2TqtL7+pSY2xxRt5PH4CojyBTxcmmMu8tYcl8zz8tzyGIVrWBjOrMrTVKYToFwBLFE+JAwjoh7svXnurKS9+6D7n56omuxnfPgSsz2iwNOJgzPEpv/L/hXJKpUBkuaZYWxddLS36FTGmZZtS8CtEDGbSBIFMwng0mauXRqTI0ubPL/WWo0evjDEr5hcD4mhiwpge032KCQNCIFFF9MTMeATYCX3qLJFT1daB1dyil8hN+SAXR3v+s5mIXEuAFTXE8VgVm1vi9E/mcKjKP+0mRAtiekmMSDvgK+TA9dEnBrD2y6nMQ+NhHAQzSZK+gNzCQSRiAzdK2izSuaez/8N17A9BwfDE2QanmqkSKIJMz8w5W3AEAlxX5LTMLfzONS3CVhg4z5xRjDt60TZ9bvG/v+BqukBbvw3mgw2l5WQHEqN0QrWm399BDuoOMQcCULPVzU3yWSpnd6vGD3ai8cJA0/EGli/T2o+NJBT88COsg8FXmGNxqhPzs2th9uFll1dhgH2PdVWbZ8e0pEWnwYqjZP/Uljcj0+uF5ZndUu6I4X1dI8HmTf5yAGRWkLmyhkTQDY6Lb00HDba+6VkqWI4D/Z6dao8GsNlzcZu5zqGrGtTXRpQIpv9MRDMaqjovRt0h5nqoBYAngpS0EQmwnmXwJf8CofqpROkoAJ9L/OtTESB8QbhrcKwAxEVf9ZNX1hTOPjF77tO6Rg1nRa0lmB8P6WhTTbdl3oiYf+qfDqDgLqbE/ixoHVd7ZqEJ6qtwMZrK0FoHHXIey3PO3vUeBIqpnSDAAJC+jVkNvrYErcya7nL6aT0D3B4SZFgok+YZebiF0zXGA/fqoi+CmXLPBJV+7+l/2Q+RtNEZDJnal42F6U70DwP5fnwmJqUbw707221oOJR3Ln8Qbe2vd38dHwE/hmsHkf25KLqOyGscxXVI3V1mCPXX81e0qY/gVkO2VK9z18B0f2asCuQNF2mkoGSVBKMQQLq+UQDVIY6y5dPpZQU6h4PSmmS40BfdJRzukgQUVqhS6GhR1xWXRg1hs13vua4Nv+6PxOSdOzJMuMRshls1tXgtkxIue4nQgIWCgQCd/qklDdlI7CZ06JpLyzvk6L/7cbqzhPlAnXVSHsmJ0vFm0+2XyQJAGBOOb+sCVoL4sY5boViclxmsAoq1WyXQa4I6qWkuxZwy37zR4dl7MeJzTiOfv91YKZeOpBPtDV3iRXWZggAmhRlz4b9n3F3+6sqWDoq0fkngfz/1imahH4Ywl3RjbAcKBxMIlLvsBXrwANOWx/pOZ1zGyG/tQmlnb7c5MgOhKHFRcA/gO5/hSUZNBKFKNaylb9qquYBwKwFEKSJhOakGIaASsLgocKGs5N0txrEtPIOCZBSgFCOgqQvDVzvPHXVsrtJvoNPMJh7C4gH/LRcleayTfpTzY3lLtWfn4uMb/PWJ9gJa9lccPr5htlPqvS0JoO9wO8b56UXK/B7iZivsmtgjLiMCG56n08e+NHQm5cMxvRdHcnJZmAc1HrtZBWzY1BWfGtg4s973CfPjIH1YjeegquwcmKoeak7UIKg1AiCTqp+o5uXAK8MCGxQr9zjSguB4KxB9waeOr7bhhN7YzTSW69YyKUgV48DVdcFICM9EqeKrevsLkb/vU5pS5kfDwzwiXWq5n/Hbtq9hePlt+9uWmCGQiMku/lCjDrf5vGRfCotj6wFfBUQVOYhzbvmTDD6kIcrOuRNaDQKZP9uMQytbQAezJatk3MEUVvLKrkWvZ63ZjEmaMtZGZVgAtr3BOKD0UJduM+aAy5ySs+HTyCuLka+XftRRRMA5KfOqW7/OKRW0YrAoaymfguwE85C3+pNhOI086mRgpqeJQw7UgWMFXdILwfKCuuQlHLqqP7PDsFa3HFAabJUqyPTdu9qs3eZBYZmrClrITSqQs+2Syvp5eJJ/bq6XqH3alnBV3/z0yIc5R2+8jEhipYARbWdowktZMTAtycJNtmgDYxssL3jt8rXFMqLjJhvoN+1DQvJPybRzQteib2u62otRfQPXYIviw+kJritHXcgkfrDvKb2NXsfWXKi31yK4m/UVjg5D6SoEtb3M6j7KRt9vxye+SoQcgdbobQRfKCqD7+lOKV2dsEwILJzR4E4Tgb+SxkZ1HKhEtSnT7bplqUVOZMri4ijz/o9hQH6SV5gPqjpLU5DREGNv2rhCqu89aqE8OPC18bIrB/H+ys2ehipkHDACpat22GaDTwnymt8yz7VGu8N1Qs/VFeKYHAukIChz50nLtPSsY0hHMyhjEjijozcIB28ZY18w3OwdWzTZuOVRnFp0nGFmuAdq6IKXX0UvC/t/BeoT0hNsb3YEoHxuXY6HnTzuECLfXNyMHHd4WCxPwdebO0PBPLdzHQK5ReI4e646zqWuC1f1xfrjeOjQGnqHyWhyQvp4Rjx1UmvATnMNNeOr5UgN46qLEMIzDOimWSDNwuf1r7UI24F/H485dMnekvVvWWyO/5SYvE2TLk4byVh7VGgzRnGrEc+IBf++B7x9Yh3Uq833jSF0A99bKeX6EiXFFQtrmDxBZDeqjN6qr/AyZRLD+kTzyNk88mCFqmNcls+QRso38Of3M1QTRMJq8qWT0nqoenl1WuszRCZjVVG+KnZLhmj2ZlcDn/1VpfdGYYdq7XnKWhMq3hJAVkl3nk5hTil2O51+UjDOLgsZckUMQVQfs40bLuw+mhw/CLi0pVfdmLB+cxmAV3BYoKV1v1lLSIfzjEHkyZf5sDssYCwWFqDrAWLzaxrcoG7vzF/Ggspo9r7QJblKKtU7/U1Fy9RJAjvNO+bzyRTjSAYmvTHwi0G8VhQstIXNxHjj/v3sHEOVOzqApnh1sVeG2CDm1i5GbYcVMk75iidq/zM6sX4lkt5ON3rbwF99PPoy23U2qB+gLHxatJS2RZX4iypL3OtDUTv3cj2OgBBbJ2o+BK344hos9dV6pmB8HdB/AKFEbmj8nUSGSwSolP87aifoslMM7OJqdcDjR5KYZTBl5CCBejfRhiTIrsEyKTuodnRkhj9vU2n5MnIrV7Hae5DR90WHK9j5msPE78mKkE8ho5Y82Hr0I91we++YvTld5OeZzJTLeT7KYYpOJw/k+miGxjHHqBYKk1KgLvIernJ8fveYScwEvyqe1engEImwT9xqlDpzAPFDgxptXHGdxNYVUgfGBa+F5n8EKXMaFBsgfpU3Wgjf/UsUYoXa4hQNS0DFN3wGNVhr0GOcujjFtW3FyvjjJwRg2jQ36aalnpzSq2LUrN2c8+NPWzt0nWjDEZo2ACrLIawY5q5RFD+n5wVE2PAz+NMPFHby6vMKB9u9saSW/sTEgDqzlTO5L1ahmGCVgtQf8KmTLRH2o3jgXIyrsk6yBKS5/J0hy8BXfHt2AM6nzueBqst/DVCnPLYzv205up7mpWSyD/Bor6pRQ2grTZQAVVFZum+Z5jlu3OBqayFAEzSq1McLD5RCyzq6bhbziaecBvz2yi1Yh1eC1g278spAbM590L1nlcA/qO2ikGaIaky/uwARX1ThuR3zlM+hSb/chnd8bcZUZ9MGQl9mBLaeuq5NXpDY+yb1n5zXPQfEHWRyqKvYswYqEx4rR94+1MDRNqb49EUn36+Mz018yrFzFYdLP7hUBL8j6XX7Ba0j/cPR2zJyNB/P9E6BfmB+haFZKCLMb8gLijCH3nW/xtGuTEFGmTaiYXc1xs/a2PIwZfYqfKEcee6tMrXeIhlZGFfX1LqYihg3qrj7OGUegAzXpGJbAFVPmycpZrW/6Ygz+m8jc6vASUV6yuySg8m+QuIUGiF6NniMXVr2BDVBOn65myR8YcQmzuo1XaXjivVWqNW6tHBMXrhpabz+ObO7fLJWUHJNpFt8HvLoTkZ8EHNHRs/0xiflsRfTYq5bKR57CaIM9TwEsTdqoXoDMJKGd5f27lIRuD6NmSQPpcpujqZzuwz6Z18/ILiznZb8uH8YOXejCoLAQyml9ZbKqzIzlX7/tZ28IV9IDwQCOK2EJhWElsYJlCP4z2ndxfblpBA+8t/E/SSi4y1xHwrB+EXDtkLl4kNR44dWvHq81hk3HuT33owoMrQKZWaS2BONYq+r4HNJw5ljSbDi1gyonBextxaiBBWh6EFindMZ68pOKi55kQrZhzQI62WWJksCt0/JdOCBDUxzFpDAvDqFS9+nsl+AUotJ1aZkRFG1qQCcixQfiZXI52SZgjiSzSICUDJc40GEP0h8V+pVHVluMbCcONWpU3XvV3/EOgMDTn6I7q4njTym3ZoPVj+Tv5LOD9ldnT1hry8Ix/Jq0vjnPKScBHnmpktK5el8/NJ5QQl5C10IRQCo23S7UGsg8AoZhdvseGm/4djNmUO005dO/5JMcp3XN+Jc5WAubSb9xnDSzlTCfiKWCy2EcFRaOd78z5dkYdRw+CGr7ACJYQnghIEo0xPKx99FUwRA3fH6Cwoza3WyyCjVl9TU2rBx7bI5ZfRZtEyHOG0/jbwVMbmf6ibx8zeqOR43fZVLz7UpGEobKZ0os5pvE3Q3epwfmFlhkFy+Q1iTuwLTa2zTGxAkvRcvZvsLiL/05i11DgqV9N0nJ64xLy0Ek1HfwSXIdOczzmsOUzAwHH+//qder5l0ObZTzSjFjhlIpoEMLzIWvcO85DFSMJkSgQljiSOz06xfvrh5TGhFSgIKBUbtg9SWAd1IiLGMiM9BJ+8Ir9W+YDjV1H49rukGwSjNuPh/eLiRVRc7VEuqw6CWDSlHj14BycQN2yFOeLUky9iByB2XOHnCQIcJznP5cg7C2rZhwTv5R9ub3GIUUKGunjZpg61N36/6PUWiHF3AmMgPZUVX5Kig7IBPnH8YqfbZnzVvR1+9rtMI+E9O2iF35my1R5T8FaUTbsT7EfZMWZXPxRN1NtKSaGckt44sjJKXp4rozutwYZgdsN11TSmsBdLgmJpNaiPbH39UbRrO6htJ3ySRg4aFSn0QjpWJF4rzOl1s9dmWq5X274s/mKiJFid8Yy8Mnmm6Hn4ZIEqfVdzS244DOJxrEdJ52TX2RG/h6mQPqZVH0HO3RnXDqptvglRZ1GHAjzkMdm2LnAILQbX0/iV2g09hjy1yFByf/WIW67WrVcjZ00bpa9pJ+w3U18vLYdfdwksM2nF2anwYLA9QsoX/Bo0nTjC2zZCjO1WqYapPe2yyyHWiefsn04Vg1RSgdPEUx1xtmkksVyG/woX6bi52lfrmyycSECf2W5v4QQc/ztal8gFahiXuQ6KSpkFPpd7AGWMB4n2Mwv38/XHPFkGQ7vz+hKwYBJ0rTmiDAuy6+enaU59K9wTnv+sxLGI7aqGJ2p+dHgOAXjlfnbGPEjjW3Rowi12sEcvsbg/zUyjqR6zo7vv7J1AuU1AA++WntaC1KGUiZrx5lMpxsNWkh17iD8S3ziwfho3lUOEYu53DtcuQ2Pux66Cd/DNmc4S3n2yyVA+kMKHH4Hwo/dQXCHwhHDUjGa7J4ACagJ2EoSEEWOWh72uemSefbELs3fd3gZ4I8U3QhAccSCL7SxC+QuHNVNI+x/JPw2jKhvJe7ynHb82+bIMlG5N7EB+lDhccHLm9b4X0CaXgpoCUcYGHMrfKpKwwsRi5/CNTiqIPjQ9ORc1oTdSYqQMogriff4cpqnPR+knHKR+H5pdX42j3pbvXPtBZTpXc8qz1+ayXcISS8aZky/yHCUbLmK6GygrIAqlwvWV/jHWF4ARHVXryKNvYYmNfRp3Uc88PHf8yIfRcU3/6n/RD4v+vZKIi4rOX/0nd6UQhKnc9pCDrfjhWEgoUBeeh8Q8SsYnhrmWM3vN0dz1HOx1OPBrUGXZLmnhAOPZ9LufuTQWEu0W3KkwVsqjUYSYKVUvPPWjJCbp+63Z1SBZOvic8G6LPu4p04NUjPyNteOFxqV+2apULNxYSEBk4kGIuWlIxh8lMQL41istljFd8cdoebef/2QwuxsuYkSyN22FADl0/OvcsC2VDQQ47jotQ71FbLHyQnFkK/TN/caxLQ4N354AMvEEr+q0eSpn9XqUx2sEW2IR/yT6kstZHFKwfrd56Rk7PeDx8yJUNix8X/QI+P5cQfA22ixKrKCq2OdvPAnjOysi6GNj5B3XrNMLkBdwRz/jL4+epqbcCgF/4shC8Ud7snBB4DpZ8ybWveviI+PTNmHnfVNanAhwZTashj+0JMnqc870Gf6B8m2DxwspNwnox/Ey/OSIVtXprWuldZ6B8+BumzseXfoutAbCpS4Iacta7LhpRAvddpG3U9dZTAVPwJJB8Uzo1pdl1uzBZoCC+WEI8W3AXl3eANWAa9xRlFCT64rk8WqW9gJ55bTDHR9qUM2jd0qKNPi8SUuZ8kXEOJm8lsY0cRicRenb7kGpb/flbAGqpJP933dxdBobeg7dGdkOnk8/BwD48wJoD2Lg/zwMdhzkL2GP5QO5+hKbu3w8YIT7SbyKR5bHADJBZlTJj40HfxDa5vOICN98Fbho+F2HBzUsGJ+AQRWTeZxw87QBN+sGzxx5sqv+u4RIt82STlJ0Baj5TwsrNVwnMsOJ5fYrePfGhuFjKdeyh4dqkWHbxAZ0R4wCla6P4EWlh6QY1l+8wMhPGUuLHmtZAD/UPYMcj8YLzBkSlDjtsahzW5LlBLchLs9pEpdR+VsyGEAJhx8mTWSqrKQO1X5LU90JLipA00I3UkJ9K/O7C5hXn6ZVbOvX1Px+M29AgLUMcwoET5aEekXmlUJNAIcxN+kP7TMo36egi8fCLpdTQv2YX4+Tza9DDaXTfzbwsPBFTsedPHnWMH9lUQxfhu5N8y5Fy0NWn0oZLEy8klIz99BOYBItfs25idSb3gMLK/CzRupXJBNSBFE1683toR08PiMH1khfFDfSUSDdW9KN2FFGbuhNhAetwhGpmD/LxmoLgOCqHRgE7aBEMJRTyIvVP7v39z9ZJKK968mT4wxO6QkZG3TyjFw0nTD1xuORLrnienGzZ8uZBgrIDNnDLD1YTLQ9La1qPb9jAQc4n2nuQCtSfPcORuOJup+frtcNq9+vFSC3+ys/OfrRNEv98OnGFRSWiLOkfK9UJtyD2DpsU8t3OSiCw0eIP2F9Wrlrpm33XTnMMhY2atPnAJMY62iLIBe6C0KDutmTM/cVndY2NhvnZd9YB64Kyn40fpnFsnuSihO56sXgOCG9fe0tEaM/EIvVNJM4ogtQ7amydhetwDa1GkSRADxCXerRZFUZOS8qZnkS4VOx8NVV6pxt0w+NhzSQckTmleVD5AbkW/wTMSKqV2H/ciXmlFcO1Dub9AC3NhrCCg+koc3oFCawpP0t0xpim+5cvdhQzQAJxkXzhqDoxeIOllfgN9ermc8TzL+cjE/Nydo0/z2bpYvpPoQW3HYT/9CGNgcoPbyNpIuce9sqG9Go8PPlvP669OKNeKLZYQOGQDcTZL5eC7qQSZa3/z9u/CrZLvc107ii46cYKHofToZkz/X6WTaagxB5G6/VlqFYQtp6ESFrqSSqFM41IM5L86wgX74kcqFSO/UC1ealbc37nJMmKrOHUOZ6IVLrqmq6mQU4XwyWlypevAw2GC2GsOH9JR716VWwT2aUNJZhsBcvPdDg2XrVLjOqTlm8CRUZoqKGzOB5ezsrD0i1M3qk5J0ZK+oupORFzeeoox8kN9RMqg8TTcUuhgi7NzX9xS4VduCZjpdJ4Jmc51OpigilBMESUJZuyq3AMd2HBaNp/48ebzzedjpXNtXUsDr/BgPxoEB8xf3V1xH2UBXyNfSKftQtMsWSk9v79DL4zsWl5b/deHyUwFObWXK+hjtmBFuwCp8XMKx8EH/iuPHpJGqQc+1qNgnpRZiZrPT7dw6HPECIUSK0l5d76AKjsnUFP2HTMmCh/SYBHBX0LheIGUNvhQCMZWdYH7l9lO7ieAzwdawfwfVdEr19hl9Xqa4s7RM8BdCcsfe66oI2HQLqezQTDh59F+yQt2W3zC3qDpXg8GDpWYSxejolnDx8gNa+q25JKqI5e7itL+uPfCSxmrXBNBi9fcFgDqfyqP6CDVNuQBmFQiQsalAwUab+D/grYkq5xDbSzjrfyna5MKddx68WRflPaP9/+3UiBjyxkY4bUq4QE2o/U7kiQaQlUMUqk2VtO1YSIRMjB/KjUwdkRtGRevQ8a/lkmSabsk8KRssxUdSBr9HP0ng6hbnjDwhz7/G9yFUc5yYSZndzOF6zvfhiVR4vJojG4YceYyUyNMgdZII6iiN/PMfIdU1pi8qYLyZereG0JtmpbW8mQxu8ZS2Ol2emULyXGg+ZEuG7UkP7DvrwXKwApJGrKPF5P9ufoJAGCGiYMhpcNZYPLTQwK9Qe8d6kDZm5PAX6tRJq6QangMXJIu+A7iNF+bJ5rZ+cwqWiFxDLVMTIa0am1ZZ10LR9OPdZFYNQkDYuJzR8p/YlRwGHxAobT2Fg66DykrF+5cJS8twe0PgwEFkzUIpTHZkKYX0X1RraSL6fcWnxgJ5yEf2WSAaxyC1wPXxlKkRzGMztLCDqmqUCpwh6CIssRJVlCv7Te5fjS1TlPTh50dIlUuDrqkYDV3Bx1sAsCeIFLbi9iZ5d/lRMb1M4ZTv/vLeYgZuZcWwg/CCKxnWVtd89Ea8RUBZ5vHVCyOkndb6j/TpfsfDIid2dBc9XXyKHI9KdKalccvTzq6p/74i/M9RdQykYpuAtoEK8HDYeNtYogypyEbleNjNC1VyT5YVqjQzcGy8E6fSyYynMBAdCBeZFQyCxWptsgfmywkelRizQzjN5JuWS46QWqe0KSK8DeWfvSc/bVqiiBPwP9l++LERgGkq5/R73cRyabHwfAOsLLzMa4v2/oI23c/+cuAF8sCP59I/LUeD5SEUDYTicwcL9IhKs4bPuOOH+pvFWUwSGHExabM11zjeiXRQ1acX8f310JnyupVVErn4L9GAUhiNRJXqWnguI26VPkd2E5E9nHe12qOEEUNyYAAWzzA/TpNsAO52LY4HoBZOoerNPGrBAgWI0XXhBt5IjVGhaEN3qhjY1I8H/agwqyrhB+xXky+DswimBpB8DSgFCR0k6Nt70wDVdNvvFzSNJYhiRCSTFDfr7OlGgoZAcEIZsaHZ6GXZOyjqKRCTVFCHdzjpXCraOIp1N3BZQBWonYbvOUI40xUhWMrhvN1XuFQT5ZxSDp7aAvWwbf9jmkWfoI54RiYhXGgcgXlBjMblZCi+iDkj0t9Prb8NlgceFcMoIdUL2UVYm4OJddhJ7uY3AU3b1d4A7hD0bV0bdmKEB8Mfz+jGAHJjfrgpTdClZiJf5sP0+LTRUNHHU28/38BUyK+32KOHGnYAq3VxsDTMyBqs2wC60uYb16nIzEf/4mnLbfvw82XnK5SiB8MfuDNkzwKn9u1O4sOISsMLGSQxwFg/U2E1J0d9Ee8h2rG53GIUiRBUCaJHXedFVLa/Cmo7JSgywj6ie6wcLs98b8C0pqs9wkzcm0gJUgk4JXQSokm6iT6ZR/zgAixhMgSIBXnVDhJSqjjyR9As27NILVpFBFj02ryGcItROx37DHYmese0BQFvQrk3nWXah+P6ip99beA8OB4p6auPIJlH3Iv02cbklUmUIezQTe6UxdStjMhmW3YCDScTRdxo0hPuPgV0LxwxQk12mVGQLe4Avvj3HeOaFes0FMTm7KGF5n6ldZtHGCGNKJQ6flv2C/wcI9+zTAax6GmIyQswnRyeY4Ui5JA3k0JlAf8LJG/3V3Vl+cEy8mrel+8v4jujhy6SBC5VkcMuXBC4Uw4B/DlVe0Axmw1/6qCvBR50O+WRw3+OqO4Ld/NV8Lmu60X0GbZAhxQbwjqlM+C/rGq0keCV7JiJGrRryUGQs67KtAdKgHBdsvUZzkUfhHAQyKp7rgbr5XVZk0d0ZPM8OHDxh6EhOPMhtks2AslMx8bPxJUHDrqL9ZoUz7eNgjSDgja6Y4JwTprgZZkWIpnSd08v4NiaK4F2pD3q8K75O3a+Cv2MwLuK4O1F3pweK3mfFgsyLxTYJILVxWEM3bcR+Saoid+rUxE/vouvyFNZXCPzpspmUsjpoI+cYNIgT2UG0kBdGrVue33uW9ugYiDbn9usrBsq+/qamFt5FxEKk8vAqyBv/0Jl7+SCIuXWq7+F0QBJ6neFzsMYoJLJKdb0krky4iDYQVY5SE6PzjTH9s+Avi5feGoraeuiGcb3p4OgnVBJQfV/KMncc4cTfIIcHMdL87uxxi70cJ2h5F/esDbyXv32WDX7YnfklSUQ2dH4AUwpXDcgVFJzKIXUvrO+KBKawKIbq1M0+LWjpUo4uLMr0IBiKrxXF3SRJRBr3dhUdCzEaa7ziNdmYoS5QNbCwrF+I3MzsUvn02IMdNuXqI+I6LahqXPwiLSIpUtPOGuQi8SYCoZCExr1WI5N7KNK5WiNiQh723MZgoY1cB1WgAcW+l+eyXrDzLomH4LzVqJPD1zA5feyGHLI0E6tga97OINU26kpZDLDWi3c3mo73Zx8ei8GXA0/MkoP6Q1XbTOc5Dner/qnFx8EKiuCUDIkQs2ZsuR0C8wzgPioMCbgQ7WMBTKnVwAYw/kKnRVnJpdeJc3GZVw+Ke64lzAHntol+glhpJXMO5PwJOV+VrqrCq45ltVBkAX4xVnXuXmCJ7eGhid2PxpI8bsrihbYUACOS2/jtoq1Xv7iG4fRnl3S5D/XsGaxCCuxPLy9XJ81ig/XUHarN5UsgH8e6F1ejkmZ/fe07X2JUbW3aNQxpwr6Lex523qAsr6JmJ0II/DUFiRYVGGSLsNWtOGJc3G6inH1N5fjpUDIzEILpcc31ervcXd5J5jtYlyj/w9q7iup7hH8MG2WPxHi7hmAR5vf2jIir+0xiJzXMVaaypIxnaTMkQKj4D+tb1s6nhkvmJEpYbM6vv1/LsULQATBmqVRgNSqs9MijLf2qWc9b+KevyZA1kfuZH7tYStSPKpKsUWsYcthlXiukFKPADuipLC+sQQsU0R6xTj1iKVybKjSlvULvhJBmdKVM2ETvhMtTGrBebi1rr0WwYQq5QUMh6SneNWA1thOAXkPzl5UGNhZ5OvBER3L849v9JH/CmHt+TcjtKoevIFWmEFsBXMfurtEqsrquanJGgSpqBJMFbrpgznWKvI5HL3Q/MQ4FraLk4PFu/x7OcHV/+vaNBrtzOAuW8wFFP4PT97XKiFkzNKxipd/bjOJ4B0IEBzBtxM3VYBqjCDaw1QyN7MWS7qgz2XSZl4x7NcdQuyGS/GM05udoM5nMO+AG3sMQtIw67s9Jh+ptpRwrqOlrdkL0GKXE5fh2PF528YxGXIlc8orimFcqC18PI/KAtUWsrhhod8tDkOz+c1smWPX3FvhHbJ4m2Ps86D9Zso2QqtJsItiqfQfvUk9plqYBSzyundpTnHdckoS1CbVq7VLrsFXh5p6WSyjhgy7BQws7zND0tAyAkrI6b5uh/6bFBJJFNYezJMz1aBf1df7C2AyE/S3+U0mkaYNYlP1m0ToYpDwVA9cJivayyAwlT738Vbw39NduhaWu76qd6EcciwwKZ+0fxT8FljKWvcQMK2HExBM/Ozgd9m6z26zQHGpGQxIsM55CDrvzb0FKgFZC/4vZdgaBXFg9YUso8CbrAkXzNk0VMe86rIuJY1s4Cqf3IQRoZrTxI+f4xPZVBJDOI7MkZ9gGBqM2ufm9T60gDK20SGppMpOzGeKG5s68sZ+rPaHDoE9F39shn3m0oi2ijIczfl5jMtTTXLU1L/j4Kdl5u/lhPcQdh640X5Uytut/Z5Mj4X3tF1p9RnPRD9RquxW03BSdUVvYjZ7o6HZ9adSgaqF+1PlDPKFsDvZKya7KPTkoq08Bqral3nycoxUcyNrbCDjmyQxOKMu1qhcWWiZy8lUoUYcWl6BBy5vDfthvyAuCtq42JoSo3/WkGQvB3qJYevK1MuYt+FoIJly+4JhJDCaankf7koO/5pNeMtYoee6ZbERyBaTR9BBvN4u0Dm5STkuFmeeWDeBl3e1MidgghVxiAH3OhUcNwLO6ExW8ma2X8o4B7FqLSCQDN0zj6T48LBhPsii6C1lQeDr6ueFg/lp/5wUIzdu5wsJBh/vd8u+QOcExPwz71tcYAxmsrRIqdULGL3L1oXdG/Q45ASd+yPXIPaV4D73A0wK7bHPgEVB2QhC9k1syrIqsY/z/jn4Kr/lJoDPaPDzVZRMV64ODJ8mok6NgkfMFs/1h7yuKIwMzxjv3gXwi9+SCHyozSR1kmNF+oKCEXY+zHXzHme7Jr9ScfIVqG0PDVP7vxBr+SvPagoVPlZQfsyWRyHm1TQaeHeRqYyifK6JvGC9PtkARv39Zm58QNbSFWg1LNUMWvIbG2ySAlmreLeeTrDd9+qYi1Ar9ElizS6+/fcMRsik6MY8TaXtMbGffqprNRChb3orJfawP4e72kuzx9Btc/lXEeE7Ln4bo5PwVBlXjV+/s2mTA2BL3sZniYoRItpcL+23mBANsMqMWmx0+9+H3+xPyvVV7OQQcpbh3KEDuUCNfjowUJkK2TvFkNHr6MMb3yI5RTPJyA8GT7gNTiZx6mcci5aspow4Tuzp9h3K8I9ZF57Q+GlCGhtRBWeuEI/O+XVKIH4O2saFa0ThYXS00m3SyLXMroXKjCzS+hEjCdl+gF2E2k3BPRRIB6j9+TNhQIXOs4HUasz4bZp5hqlE3oOtsy7PEXbLTjCJtxA/nhXwezAT8ZjMCIiMiOjie93VnPjLZR8i5z+lNrC4csqaHltiON4+XrvyLuZ/IEIbmjHUyzMa9cpusxjfXkAxLwWp405vzFEPBik7fezs1A57cUvAYXKc3ac6YZSdUZUgJfoiKW3Ocic695PjCAU7hVLUWOdlydM5qigwlP9AVQysqM8owBtfxsrNeUnX9P2eyF7ABwGnQbrxPeR0MdUsBlw/KkmLrFf+Hz1ef8F3GCUSg+2notRQkkw+5+7leVDR84nTDpCE0waI9nWOqrXAYDEXIr9gHMLOoXbpR936rr2kDA6JD8gMIVDHVnFwHcScBuKyneayeYJOT+3QJD43OmIl6g+Pfk2P4ubHQDqHGpOOrCZfDTaJAefeO7a7/vicd9gv+ZmXdwhTKNorPXXCxx4SnQPCa8KCHQyYGW4lqXlZqiWklDAvS/Ln4vkal/BMd2SJWahnIWo3JHxWwCBHKn4rQIxz94muqSfUKJFz3twaI8N2FInRftp4EOa22EfB2/AoxkeXV0dncH0vQLMjEZ9ZKBo55ilD0SqurqfXLcKeoBZYfkQ9/CySvD1L+fA4ETjMFYNs30ocEtzfOH3aHWgkydTrmIS4QPXEzaTJ/tTFCKenzjSabwpZD/0khsxNfCV/vErEeSVECESszEylpL/lTdL0Z3RjG3dHhQvzcSxqOy+Ef1qveZIzC2bj8D78K+tYqx3Ew6aQm1mWv3Z26nLgB8Ok944s26OcuHy2ueEw8KJJbyo5QSNenyR7He353RSDm618+sm532JkAwS9NRMmfvB7mO3rhXu7eBi9dJl8WQGcN46ZD3PEy47nbf7WK5dO/i7mAkHfCGo8BvDf6MY/ZSZaNrSCBvJpF9ew9tQatWqFx/pVqHBcUpRHDRWU5bDNk8XA7Ch3cWH3ihtJDoQt8V0XC2QXtni9StsGmEh7qfgauviEZ+IyHjerjT2Mafu7dWoOtBj+qC29aHomNHn9T9uKaxF1y2QIHhOqIkJFWglebnBO6zRfjM2Y8VFiFplZClIRT3hmOslehAwWuVWxH4d4jqMqDVZEoDD0Ca9iTOUhB2LNgEvPzBIOqZUWK3R8iXoY9tQ7Y+Qje9TGZ4SxyIIr+59bbi54sP5xGp9n+PrLkUawv0ks5czluQkbG/Ma3SGWxEHlyBPf9mrvW9E/hR0XM1VnVtwbZQ7e1bIygdGQD69bNbM7/pNAhQ2Tt8pLNMwCIDUHonj2ns5HZpyth5CzonBStd2FZVDfpMP08EeYad8UnPnGji03K4IUFpXBfYvsTF9jqiCRNYeHNgXIKDut/73apcgMK/yyDx9E6lAhpCVBU6lHXLoVIwxpSuUd26izOMiR3Qs1oSEC/VzML0NPhznG8UwxNx1mA3onbihslpMwA9KvmBkNqEq7ZBZKoTKzvqOLDIi2Xd+2p3EkYzViGIpbWnRnfahScbGWAYxtMo+pT8DZ0GluS/BrELRfCF7e8jsliSJiz5XxwRoDaVpFkT2GnNbSDTWzsxJmdgoyeYdWxQB6f4YW2HAk2X0rtzVkGtRAtyLMhfD8uqTb4YrElUZ3qCFG/R+E8zjLdBd9jaev3zawGhbbWwuagPOuw6i3DWyrXa8Fc5NShd0RLQx+0S581VX3Own/Kp1QsVZajXeYaUJuhBl/ZG+BN0IGKOnbvBIlj1fGJMYkFRgtBLrHAh9V8KJF+KdLMXmkxyUP+DkXGk3P3Sf7024tSf9V97bD17M2YG95BJiNs0F7QShGzicGdg/7JY9+r4h9c7pQV/uWY1KbgGTFbUZMGzUiT674WsqNXQ/zB/NECNsiiS8bDaDpDJXeoNMPI+5x0NuRWiP2C7SkKixtxUbrj8B/Jhy3uj0FtfzeaCgMe2Ooxz2cwsggldL3y1og+RuVNJAMzCLUvztqFp4ffRxBdOBeqSl4/wUgoy6EPfo1VVkMxpmlr+eM9OGfDycKOLasqyQkK63c2uG5ZyDjEXHqrBgH269FZtnplz3I+1yABv5LmAKP7T/u9oxNOUadQ9iCi2/hu98PtIhdjZzsrBWOLPJC/e2z/8dceFZedtiN1SLLZ1U0fKPhqSK+lLHzrjIgdbEla3aT6TlTcKPz0AklXHSEqD2I128Om2y0WiVKuurQiKYJnqTN9cZjB2CFsXBfqxAY+ndw2tJPEfgLSzbWG9dL8ge2oYqS+/d8XaCgUIu18NtPlc+5ew2eP3bK/jUox1ptg1tWSG+dakIO+/fdZtvTkZfDczgXBx6fW4yZt2mlwCEvIuL7UHAkKurZ6s5ouxuijcyFARmHHKHZF81M60VqGIYgJLX9xocIaYQlQSbO8u6o46oC13cRL1DoDiGC1JKwj5+fWFsuMvZf+RgkU/ys5X0SnK/B10+nntCyVsA3gsNT4DuUzfWYdc3yUgEaTXCr284Gxc0VJbCLM9KpObAfTUh4nBbChonre7Sm7CBZMT0ojLg/lhAoyhCHPGlXSFtRtDzzVPjSkZtFYWnZPWd48fhcx+bGucQ5vwPiv4+Zsu9ap5z4T9rgGWMs+802qr+89yLQ7RtD1100X8wkZihc7qbFygcFme85DCuFMvq0uP4nlde6DwJK8E/Oo9L1J83+jfe6oVchE+Ko7vX3Ih3iqaUUfRvdZe9rw/hJjY5YxIzuZn2g0nUmYHLZJ9rhos97xr8qm/N4MhTYI6hvXBFVAG8h4c1kvaGclYQLVAth4EOK+QP04F1d2cKMpMCIjBdfgxjblFw2g3AlmI4epXCy9IQQOWcUgXuAvTgI3dts/onIcq3y20ItOHgd/VtmZPxwxb3PDqFQiQcML3zzHdLjc+WTu0eoAmjnjYp9sZdyvZSrnBv9GOy8FR/AW5S8mpTIT3Tkdk/6+hObJrCjjX+79iV/qBwFlvNfFzF9y1Kt6uPLGWg59ifH2qYBPQ+0tsWJGY94nzTup5VEpYo4mBEuROBiCnF42h7jTOIaKiWOaHXbCRqbT/iHTnT/ZAn+a9Vgt7kLg2lQ3TqXMZW/wEdgZcP6LEx0W944X10oZB97KUGLjeBR0gtwIUmCoY81Lb9awKarLhgPPObBCHODexHynn13EJZ8gqFoVhw54IUJ6VBfsaLll+uynn5rJqyY7dtL7KXIYMHBQjPtRjfOyc6e3GeYd5mH4ioCy7XpXu5jvFxmDkxl4RFNpy72HvUBfvjvl/GaDhiebhlgFnGZsO+JRs641cNiUlL8lvjdBXWMkWThPuJvwaaUPGuorZMhGoXERhIeUI1ZCDhVW4oe/CLEqLR+oST0KUOEGPCn+ojU4SKG/FuXUGv007s+5FoUG5QhfOODOSqxAtXdi6JMRuuRIbuHLXH8G0UBSxKsBlaOnpzAcdW1dCHw8g0iSRy9ZE9JcKo7o93nwrPU/MuxWpiPFXGdxUgqzhRlwx1yAcKL1gQvE73PEbM8q8S6j3x1ql6HJeXJfhTQgNgvnh0YRKozm4KcLsBfHAe+prBadoZTyKGhdzUuS8KPAfSLneW1Gmz8V+B/ppUT9u7Z1sre23hlRy743GW7EsBrW0gvuADh1Ybxko0ru5mVAK7RFW0Cxph5rx65OmGRv/7Aij+QXL9XaeXe7OGzoKRYofiEFtxhtfi/AsJWFf/OMiP34XCI7qyxyp/yya+ue/GMSNnH17uvvQLsOVBmZ3N1Mp0nm4l7EdjNWlvyzoqnPCeDNlGP3IobvWZqRQ/aG2Fc4+r2iCGXMPOiuLvu+whOMw4omoBxvSDCnsJBvnXuOqmZZz1FNCaScadoYeG71jt+0g6HeTSKR0zR4KRFseJh8SrDBk6n59m+USflF2EUV5BKGL40FF4xsoSqwxyDY452eNPSYF6oxK+tQvYslJAjdBd2yh6yO9F3NuaKC6sMxIzlS8GFunr6QHJC4EZu/AM+CBTSplh/J8NxrPCkxgscG6uQwRvHyfdDZrDO35hOXIKcHrZDJIfvaAB11isVHMNotP1QdYu+9xO99AdhV+faUlo8TiO+RMfVuYz9aJXnOhYo65a8az4xe8Pu0pUs1ScDM+wRQYJyto6Xsq8g4oODv3DJhhFzH0NG3Pad/s0B1eUCx+oFQZ9g56G3OqVbEzj6AJyzNEIPoDL41S99nikRKlpnxuGdxLy2yVHuIflWvTum0u6a76b3b94c/fmCf4SwGl0Y9j2TMIDTbIfFsbIdQQsJ+Pja/rHz7G0Xsy4OIrgpQOQQgBBRb3ObwxA1FrJggqFPTYSk3EDWTXtjFsX/n/hz9bn/QILI0QfrTpwh7CBh5iQbot95cs+0swAthq/ZEdTOLs+huyd7/PTYXhkpXCb2Sig1PI5VaqFWLetTGvFRnkCuvmawNHmPAZVPTCg83pQGeiqCF1UOjnDG3OWgPSHhPVUH4o7XYKVvOLemFfF9qbo3S8SUPwC6aVz0c0Tk234nWZ8fR/9ivaVNZSwj5xoQVObM6g19EPLEpCk/MKT3QlKMS3FG11CLc0FmC0vN+r5FKQ2r2Xbrtb42sJhvfi6QigkwgcikE1eDuHD402Xj/I4v57F3+LOPa4O/Aeph28Yjuu04JWB3c/jrC/n5ioS9Ae+t1w3pF0MTaEq23FLbMXvbjtXZExGOIYsr/VW8ValeFNaoaF5r9W0XLfH1+ZfaujQWZtMi1wXmVDYX7Jmc6b7l8WRUlHAG8nR0l2jOCwhxCboW7EPy+wDIExReh1iPuONesT+BsciCgwOaZ/p2fGxguoMzZYGZ4h/JAorbkxrICFPq0CHrB8vfLHYtqi1IHXwK56SZpHkbQ59Yj9rLc4L+SzPFJUUZv915qDxAbov8Wrrx9gAoRvnfJ4IkJnkuZf1CKIoixLCwFJiiANTBx0BohSIaB9kqkuYhrbFyNJl5EHtCQspp9cXe5D4Frhp6ck0kk5ZJgY/CqmzeIAkReYJZmgW9DFSNjUhDZjKEFzv6X8noYb5mS3KYnIH06UuCSRNArEDyysXMwwdT4yqYeuqprfRM2x6QFS69rzxJyHq0tk2pXm9/yP5oJyIGxDLnMM16ogHRj36dEACzcbq6Jv/xbpPYtrM3toRVkYeKNyBjZLI/zgDmmjaxcB6RrgPyneRqpG6RDZQ+wmsFUdX1ElFUU4g7G+lztiOeRnJlSvdXCkeSG5ITs0sa05cBsVWExykAxJVnrnmKX5oQ6wShTI4RDYZ80DQOgOgNvItfhduODo6dvWoIZMiWQvlFIho7Wlil96R5pisjv8MxBiwwbt/ozdFc1gp58wsN1e7aygJQq6OSscDKRwjNFoGoQiOazDDe6nCnTkU0NQp7ttGGQT/obyaoWEyFti/RYCk7D558q/8ixi2wltCylJbnsHVS1pwNVJk8eGvUKhyFx5M21pDn0CtobjOoEXLvo7k7YI5fS52DvNJuYZB2anvHiw7j64BjuU77LTR7KAZ8H6FHn2qcNzQc2N3ucCTdL/DTVYsQ44MYGYAr0ks3fl5lnx7gyKCPQ7ohJQZ1YKOfso+D3bEDm6hzg+Vv6Yc6Ee00ybPVeQquMbfrAdZ3UiJGMyPs1TomIbYYagT7MTxzr6Nq3jqD3lrzsgVm+spw+wu2qFYUaLeebzPnE7dDe5er9SsfhDMOEtB1R4oAmVVf+c095o+Xf8GVDWU1gZ/tWcUYZBrItn3xYGhjG5aoodcw7Kcdu2K0CDFHC7S8MZlxDXEmPoQP3n/KAaH8vv39+a+ggjRDnewOox/E/Keiqyngh+SvizT576/6XSBpTIHmATqdPTDfKu2sC7e6ndf1qvv0xxui5YjpxUt55NySRFAbSJxaWuhnfeTD/J7+rK/pZOr83a48hQhKlcK3FxR1klU6+jr3d7t71a/jYKRHOvsQJqPE1wVRmKZVUviF5UNEuMqCgJxiJfJva6sY9WgDPLuSmzXjywJJH1oISnfh++k/v8TUUwDJ22RYvuhbp4fZmMzuuC3fYhRvpuXJiavR/ouIoKgPUwcxsQRbHFqzR1ndfUQ3Of5WlYq41mb8aECKu7Pm0gL8lDThLDRnJfCAArYFN6WMEWMkk4CmoLnJodr/OBaPH8V/Vst9jPcWFQMs4U53lHmAAoBlkfU4sZzrZq3X9mSLXl/Ch8TpBndBqMSD5ElQ8G5hyOCyQAnUzwZnhEVaT0Xl5TnhEuNAKRusFVJBRKL3KaEXGpV03UKE59mITDKeQthxDWq49l32LoIpgHXRtqvu+G+zAgOhG+90XmmNMWgy81YMbmps4g09JYEfDo6jP700UjxZ4+U6LIE82AqZl5/tH0F4cmnXadc0gv9gXjamDfOO7dacvRK87/2yJFVe8vhc5sykYLCJCLGxKCvoO4pe9LvNuDQ58hcbNjIk6UhGAdJBsEZ7PNkJr6RfU5YNV9liwk/tFPa+PRplQ2Lu6sYRGbGh7pUdCmXS8aoz/pJR0afH+e3fle17qqJvoQ3RysVAGfX0iTbPeW5KkJRC0UdqGPiXw4X8YfuHTQD9xCZh+jZzJsURPUSPsuJn+jp8puCDQYLyj1nLQKqDi0k13+uGxyeJ30a3b6DBnYqQkcgIWVHWVyH+ql1sR7Gr5/WB9J1TOo5l7R9HCVDmf6QYkH+PwEviCOz+HPFQIEMRVc84JjlabB5XXNg5OsCz5e+c/mPsSaN78Krf512RCWhogGzo/eFv3uPh0bQMUVU4w/nkK3RlBajwUDgbDjcYLF6pwwuwjuOCLpsByrf70KON5HF5dMDX/8uBjNW/Z1KTBKsmX4+K/j6n/1diXq8WnuyqGymrS6z6R0gJ+12Oo+viY2ah2rYqhmciXbYfF+b0NCsLj0W2tw2thqKuI05cTN/xzZMDW3RDzEioC/xwnbtfukkTepC6Xw/2drXop4tR2x6SI+/flhEOWvnUmNwnAvyQ1cyogLhybjn91QKRKXMp2QukBEigpbvgwUr24e8pdGOxK7rgCi2cgPgv9gcUcDQkOQw4Y4qTlMC359+w2wLSxexRL4uXA41FqLAnw8ODevW2AS20UmuDzieL6YOggIOkcohiPD+TatozZP3BY2vvo/rUN04KF13efLh0NpFslydF97k+qqcocPe2zwN8QLLlFvJ4qrKH3AVh0T0R9EUEtGXxrFicM/exsRqJYnw6afcktmiZuhXmboezI0Eq5DSJqBt4qFV6oX6lMacKgR9xw8fDmQ3m0W5jzCn8dWnZBvBKdzwpcwc7AJpGnLS9ltytOoxISVZM0XweCamUMZa89emWRO7tjBIOCTEs/T6yhYluSWu+nXOuwI6MDXUgsUe1BwbxucU0azvKGbG8PZ/n4t8GvfRZgUlfpk/3rptlPYSmtRd2U1CGcKiVrE1iNSTHeXXHwaMxuasSXlxCeelD5DoVmFjz+w0YtuCLZUJOjhMqgeqABuuX463CEOZrykbPhYsoW2mBSqsi5bdAM9KXWn47CQsqHAhgyqs1+OeF+1/cV8vkgZID5yQFRxVgC+ESmgJWbh9A4LaanzxuJzndepT+8nonQcwD/V6NLqmVH26bQbQhMHTeZzDxR+TFKKNUL7y27ejaPlN2X7PGt1HfZ7lspYCci8i74Em6Yew/96CZ4XHcmeI2qtyQPbmmg7e3kvtBDRTcjCWzNB25IzzHQTw+xU89If6uMdDIulSA1ABelKM7yM/GarUVrojI9VQcE05vhSvhlckGVISoCIDtN/Mtif2WSI3zQ8aBvhmSuM1/jZYWVCCdsw4ZfkhYTJXNdoOV9c8BDbd5ThwFb0m621qsI3tCQSHMzzTaQ0SSINlCeGyVzG2yvOt+jkPsT6zht0T6ewFa324fnAFLl0xgPh+Ki31XJ712vAqQYqe8lGGOLBddVqn+YQSvRYS7sqGcxHhwR709hEn3BfprWhesslJ6FQCN9wMAqmzpyjSZk4EIpVbocdt/bTzzPrK091F2+ITCIhxbRZ6Ac+AsLbeXs2xjbOC4Ql6eqbbk1lVDYw5sKj1m1ZVxVKTUtn+zzd6eyMDdi1I60ySEKr2nxrnp+h+wadPMWqfaXE2F+Uc8pILiXhMgrYglMVEpOzy3L05F5AvzTp6xfvPSaA5MfrlEBZJnHM2SesDC3ds5SktILhlg8J6pXW9q7oMMMouprNDdHonuPwbimqvhkyQbAg/myviqFgNXmALXDOVdV05uEAq+1edrUS2vekHxv6yfvuwSRA1tsfp+7JrGbolMYVpfrIzLqoR8lKeygKhMpCczw3y6erF4d+RdJ064UnDFdwjSl1ADylk92OPvTHTqWNWo8Hq21ItmyuafAhaRYZbExToEBYcz1Ek8+9u3x6llRoxl+i2tUHuvgmnfDZCn1+x81hCvm18lyzaf1EjEIzQ52p97Q333MdrSgrsHgIww1VqHIhWmYFnqK9fxSbOkzjGA8RiYNjzOu3josYHtbCwCgi4EnwP8K39UnuaNocb/lxpKocd4tmqpoDXekYlVRq6izJDnP00IPVzGNQQnfp+vayPgRvHhZlb3BGM0wT6uk6NHrr9pGlZqL62IqK6IoFKU31ErHKAySKcE8U7dMoqmU9dhbOBODbWNIejqdYR2HIyl2EWwkG2WjWEw8zsQrAMiP0CZirSVjyKQ6KDOyH9FFYbKBODqTozW37SuRFdTYVZ4YBF4gg4mra3qvc9a8zyfJif1+DcJZ/t1gSnyN6RpEQVbecaFf6gVxRFEPHOdcgk+pdFRb4vO+SrCAB3grcBVKzKXO9Zm3/HJwdInI2s1YQGDY6RUnMjCq0KlYND3c4Tl7thJKvP9p75OoNMTbxbrcsTXsbYBcphafl/NUOA8/aGFbzh+2wQv/8JlRgS+8x7Lz6lfQKHufhjzJRkOamvpICcO4M12m1Ytixr1uMDSXkiSm1iRjMs5Dk0qu5mYo+5d9fygi2vd+QyN6YzA7FZzOL7R7p4A0cAwcN1a54RUvP9VsPZTe87ZVeZLShBXqL8p/itqsdQpjkQZqCmPYoyrz8HUnwFQ000BqNeG4rDevKs2nxY6f7lgXzYtkgPFUs0YtJ3572GZYKaWjWvmnkXDVfWPzbfTVlDGDM6P3Urt7tZQTtILS4WfhPBp7vo3uyycmf+7X3aJPR3Oh0z1nOBzKVZ5AlY3XIJaEdcCZlP7EtwVwh725QADPPlTPTRbZKDXNnQ1joWnxdQN2sRiE8KTTkTqMO/tLERzxi9cz9SXefDKfzVZ+xSTbbph982i8zoiFbtdYZi0CgATFuaxYzNZRGygPkMeJqRXBJyKjI5GMIwjWgraID4H3HyLpu4AgiEiqDMsQYSdcG0hzReVU6wP5RRkEEL1Y0GS5JMon+j0gzmzDX1A+1pn9BrjIXz3MrFlWt2SSSspo1uDgPVehlydA5ixMqSjRWX6rG2DS7MmiCMDkDL3tDV8pbZxBQJRiU9Som/UClKNszHnxYvIKugudqpsmOgho3UsY8ISP2US+lPEZDlIGnHQTOaW0S9QZEN2koUgi4GKljqu3dqS/5GHc/Hj/W1fSy6hx0agy/mb8QCSFMxdF9lLRYcdGe6ulm0EHgClRU7pyBXxp8kjCHa1yVbH/lNdmuWNhgkey2mMjSsMWrAgY+yjzjHUjp/IQUk2RxVooY3UOa1t2hjpzo1qdWfA81Hl+0EkIgz4ZE1Q8NfLdtHlIPcQveY9yiGdtckXJxembIByG+7e7PQaOb/gxQ1c7cRG9KFbjAlXae8R1Wpag2AIm7d2ZdKdcUSm6n21zSTWGpWEs3LAX2QyITU6vPUlwsWEJhvUydH2qts3/6szkD6JCMrlKYbPrPZKqFq6tJfbLTizZikYFHcXPqhFfvk57nuSpuorzqFA+Y062PZypNWGGkTgsIdNfmkBUOO/Po/ftMlu6HEcR9+Zwzy9qjbEDIlM0KtHHnzxYPGX16iESY5kYYF9CRTU4cWyvopSmO5OE5+aRVEf1ijgPnrHNztDjh9dLRu5MeztI3aur4jRCzOakkomK4I906/IJLd0sh3E/IrGROvgJ+N+rn+4BEdyf/7huldvkqfv1dPn/xgPJvkb4BNhHlrx/nonGLTs4t+fYfE+Igr025R/xenv/t9Kt27a64g9SPorR2/pFkOOCsxDnqLiHBWUb23UAVzDuuSDREdHFFU0x7wd476YQBWq0GmNObn467Hur7eG1TKbmZ4o+8Uqidw/03vYGobhibLZI56aLMpXTzVrIcJPYLR5MMNiNpsi/n8o6VedoIitVYs5TPl9LcNFNGpVUs9RLtKv+mPt2bs6ueCizylTTpKDwlQ5F1iqhUbma5xUcUh//vqOfIVB7Y7d09ulEUK9ZCApuwSfmVAwGUH9Y1vAcxEMRC9YElGGDaLP1mFiJY6lx6nepXH+lDo8ujBonuFrjVWzurxb/ajfeJH1qnN4lh8kUNZJ9hN7H1Ov5xwiscWxANtuHij09kO9cXzTrTbQvojprqPBpx9EPbSGNAIlM8r285fzUdb+iiEfEYPn81Pz13i+BlkisV1fCLtidxs87/BOAnViHkFHhgBO8MHGzYDIEbzaikRfqFQe7NL/FoGUxWPyRvoswsBL8yPo3HX9/6JpAYIJxQKiRyzzaBHX8MTIA/LrIRmChERVv7XLhvj337M3KczAT3wzNIACRdVo4kBFkAjKAv4RtE1B6boWRelLjIp+iEcV5lqfsmF+2WbB35jO1Ovd2Q0wF6vqzCevZxyQk8SuAmVNtc6F61TQWFZHj7/fpSd2ZLls95NUVWkmtBdm6UMHOF1qdBosMerW0HiGMkbshwL63P+b6srDrkW/IgDBkJ2roZ5kLoKdIzI1KVezgtv7EQpzgu3FtotTNu0h0LjXiabtcyzSsN0ACDtiUMkSYsb2tTU0zsgQ2/R5nPSpLFhrNRO2WJQ1HvnFezGYPSZoppV1/zZFfgKWFVSd7KF9OHxBngxxkw6nceuF+2DSYai9PQV/sL6uOZ+/entRPSiWGaID6lEfF7phx/SxiEuj1ckKztuobEZkzJA0Ftdo2t+qpY/E7jjVGNkJ1u7yhRi0djUhROIx7ZKhSHNR+KHYDAL16htyMNuqCFCp9aEk2EisSqcOe5wkAeAqSIvl0uHUhDkyPTDzlVfy1l8Zcoah71b2vnQnaHSjJ37s0+vLd1kdiA7ZvdQH+IhKLNqeVCaymwuDqbTrN5sxavjDep/u22CsYrAPK+pguJetCGX+4hScx99RcLaWimlSnmo0YfZhAzC194/ChuoSnpXjCImjiKmhjAq7pLgHRgnSPbtj8fWsG23aeldMxHxe6kLu8LXTztIwZAQzDvLG/kfCd2kUZTVXDn4hueSvWRrMCWPkBpsInqcziIpx45o8uMdDoajevw6bbC0gshh00B+euvxsVZ+69D6uQ5gfWhXZEK5S3nb9ABdJ5AmaH1rmaLy7wYv33/fHTCRg3Uvf3d2OrmCPAz5yYoo6NZZrL0GPIfYL55FxwvWjs0n/i4qNB3N/zeCo2zk8Ubt762SUznVzdC4/u6DSmDjju5ccLjYXqJZyylwk2YW3rvwYRo9nF0QEM4M4uIGzYvHO9Z2+IZNG5H8epxg13FTYBo+ssASIzpl3y4E8ExcFjOqMukns0I24O69h0Fq+6gQcvIM+Xvk81Izh54In0GsdeEVx/QRhxeFLylUb6jH06vLwn0Xoi6cOkQU7W21dj8T9e2H+8EOe2sH3LW62r2h5Y9XC64l/NVBJhd+YjcVh3uT4n0pbkb8Pt1gOE/GkCVbuympS9PJEvgvjVEDs8E1BHC9Ke0jfXTkEhyE+hwoFjbHAdgcTVgMqvj6i3MyIbqU5qUB31RU30iKmsu3FbtPQsM+ImOZDcFxH+3WtWnv0FAKv3RU1wkFSePMc4p0tYPx+GoHYe8rBZPOflePYwor+D+FzGMXU1aeRFtCr1FoQHWc2eVAi4rMaEV9MHqEOIqVWr85U1nERXpI0w/M/KoHzy/5BFIYtElX8oiwiyBh2VPFy3q949p610v7bUh94VnMREL+OaGHudabxNuPO1k8BHhR8SeD1Pifl0tuudI/AJBft9xBzgRs5ukVHhoJ+sVTt6yHNwjTd99R3lKH92ElpuF8S2UIn0YB/9+vUlMNARrO0rU8iWqb6yf1KooPY7M4wp1RfZ1ZWpHvh1HGwd8QeeorN7n6186S8M5ACQW3V9tq0wddMOhZ9FoUxDKyE9ZiCkImhAL0+L/6a2NRURJ3RtGG2ILzjo4m8rHAcRb08NSNhzvW8ma5JEbVGb0QuNS3g1cT6Z8zBvZBHumwibMqyMlgO60mHoctVP8ciSazJCyt3HWeE6aZd3M9at3sYRjkCsV6pxC3Qax5jgN63ieWEOEt6xGau3kEY4sLIFgen0R1eOAXDb7J4wCP1mowT0iOtlBPcQJtGm0ZVZfYahTig2MM4GR9W5ifQfOF9GSV0GqKijI9QbT8PVW1cQ2MhDlkx2XHO6cN0bKa98Ewzo5GWCwPwGdLGhg4/QVu/QaI2KwpoYEz+bQ2/tMji2t1+rrSsau2AUgXrK6BM6tSDLmqWr4hHGY/GtgyYnbQsmoNxnKPrimctqwweF19XE4GQuNOahL6lXcRUMWR6AxdzeFYRoFudFV1Yr/gKhmP9DnmJGhgJal0IpFnbn9dJgIFhqqMMZjn4XfJ7JGr2OL0dPoU3FIpHhYG4JdJtEzMkL+/g05dbaEau8MPmBo1Okapw3dxI7SWkp/hqiiAkC3FwGDOHrF3PbEXVBQH3pHm8xkbnslfDthAutiTBE0mKQ7kfcKCjEkUz4XaAHGjumYJGGfPxhlqOFTjwr6u3uH74gTcPc2lT3iThVqeJQlbFN7/VNW2fgmBUJNU3ekTbE+AIJf4cmAPAMrEvRTpQbIjB/D0L7CetnzsU5T8olwQFmgR9ei6zQA4IjbXKPwE7qYUBNBx7EuTBPoH190Ei/B0zoRhG6Z39JGRIrUp2aRq7A7hKzUCmG6MSCoyB9SxKLJUTTyfIRuTdwph7CCisE598nqtIDyugXROegjsewI+VUD3Kmt5iy5mfLeKivaH+tvSzL2/HaD03S21qu6TV16MSQ+uz0yu3orgrErUGF4TiA85/He8PrrWyOy2LooII75tRp/FGH6gtXemVHz4rU0sR/9j6/K9FZG/OF08gnRQz79U/b4VCFdTiqKKKJ+FtnRW9ndwv3srxjDAZwUSknqkGieT8cfWdASpYUtHVnnOPgdsM2JAGMsyQy7+1m7CJzXcIcH6zeMvBPw0OrJyxiefWB9Lhv+aSFtbfPQydZorfbkMCLM/6FFnMJDKQ1JUQ1vkvfsrzOEFr1LmpJ7+RF5grY1PjfK+o4hp585xEDDwR9PqNiyFXjsELQlLAh6SvG79iaXjQPXkjB1xnakF7gcZRjQIiZl48vFOcM1B06eMKs2Y+/YJZf6NDuZBiLwZKO9ELkLJcWAiwd+Yv+vzTVWKzkkgfYkEmgWOqrZo/MI+jDYjXMACzozXyhe9HSlI3yGTLCP/gK3Nj0aR/Z8q1H4tYvqoT7wtOonAmbH4gh89sXE3fFwXpK9diis0W8aHdAhAQdHVTTsOwkNmUiIHSMH/Glb3eeKxRYewZ5b+hlsYpE5t3aPfC1/l31vbGo2VaofS03uZRZMKqN67cVbtPBa6JBRL2nCshZYIOgxd4tRSsDA9nQwfJF5AbL8BMwuvqXFJIoMdFb85BEm417uw87dSUqsUHClI/1YGXpliW/Pc7gBlIbx+NyCFeEPMtp4ZeiW+TpX6n8GQTCN27psu5lk2IS2tLznuMaMOBSUwn3CHycDoItSBol2+SeCr1GQnyvz2z8d6X0AjnrnMDJBsTo3d+MFeb6pyTIWKNhr93LFC8o7qdp1shCslsI5eKvcTh61atjSodZyVgg9Fh9gg7kHmZ+52PSdwqBnYnKvbtvXv2id45g039x5D4VtmhKkT2D11IjX4Er44Ckz94BYxhbVc2ycssPYoOTgmlZXrDk9wSnvqrCpCLXBC1uY6PQq1B/no0Lxh7mYHH9/Y5ii0O9cojUr15kSNFGtj9+mBb0Y67xCuj+AcXj5SaH53D7ET7AI7rLhYZvpxX2I167UUG261NgilPvz8eO8xXbhaJX5RrmbHSIkE80172g9asB8wtXpBQ7Cf6IMYxE0iyjirV81c287REfsykzjIb6J4J1cKKkL2Cyr8LnqynIV4uyMaMkkBpQe5ZpFlu1qUli73F/65JUAXAXA9QB3e2E4cqYeZX1cyBM9ooovDQLyBo68e0yXC+RCG8PU8ZVbpTgha/vVWN0dw15KmyK1hOo3sjCmBDFJ5+/bWEX+Go79VouDOZJywSoe9ueDZopOunHvRLjzM1pCt/DoROhVWV2KMo7sPGdUCx9b3FeKeG82GZY/H178JXcYlIXyQA4iK7ziwKAvLDBWv5KQcI2xdYi24radW6l7WwEj0NcL/r/y/fWT++VEc9uzk26kkymfZNCRrFJia1W5UALxFzZSzRLxnMFp4iG3ilX/IOgx8+GoIQtIb4qIe30IXSkqY8BNSsIQ2j5ZKyS8f1p6tZc4ZCK/kwJiSk84DopR5Q3lq7G5eGaxF2lxOkwNjZ/yBc3InzKNkWOEj4ItkDRZQbu7aao2qJ1DKJnrAdRkNdwHbvnqJliRj2wBRzqA4+EEyJD+A9WVmEwlb5zRXS2ikLFXLZ+JySygiTKl4nQKMSd/mjP1qa7EO0WPuTEOdo6XtLTTOgcWHilrKZocZPgK3+hEiy/bJ+fe6jMXrjWhdeVhQOISoMA1ZLpRMu1Jyctu4U9D0pejAwND3b18oynd0UUp/2JGv6D8DnEwhzTCOq0qdmLLp1xmVxei5McfSi1N46qQyFLzHxZ9s4tVDKrYLIDiAdskkOvsJZDAj/RWPWeR06KCJOlexMm8EFbPeJCcH0BWXADpnuvbPg3zrqZElGRA6+WAzgnmS7GIXwLAJpRTKteBamP2eJgD7ibdIarPfw7WKpK3FnNl+Y2VEnshOmcQ4S9evQjfHU540C4p+jfenY8zYjNuC87XNvQGyeCzwwQVw4YCEHsgTUKkYYzRwaWXYIkx/5qLhXSRkPRNu/yaV3qwJ2G4rArTZCDKjmFdCD3bMJQJbLXB1CdgK/BW1o8iZgUpibOuUxQoSt9n7C7zaCJZJCW6QDi0SY55Uqy2HFMqnLA5nEU5XJtWJ9y3tmAiYQceGGqwmuGgdd4JRxCE/WYLDqGszgSKKnW0xmFdlMiV6tb2ln3hBaVNB7M/8eEpUe6CE0Vew9eWKNtijxCwWMbVst/ZOgoN8oq/Tem7Bkyjgq3iPUIUiVKlybK1iU4QLvOhHPwopJSW3XsGhfTECMOLugMGRE4qpQStfEDUGGFpJTNY6vxkgwVY9VdVjfjKN5ruC79zq1cpQdnB/iHGYTLBPumCpQKVMARCjbMEr75f4k3t4c60z4dTHlbsFtkJRUmtQrYKF5OEFu+NoTh7QpR5+wf+7291PvWB6YlPVUpv0ZkavncJT9MxI8C3CHldkZ3m2gHXVnwxO6YlABYanbNGAq5ReAhs0q4bxleDFXQI5CL456dPXv+ZflM3XzF9MzvgDmLUTuPblpyY/x9u+i7ISx5pxcUjIP2lzMvUhDlxlUs5H4hTLklussWb6MZocHb1IBi1ysNrsYD5qSvzFx1UrvcIemQV3CaBwEov9Jm4mHL4bovfpls2ioPF0Lf993PGi06KWut0t8aAo3EcH5tuLZTI+dFlLUPjnvKEGMBhdKI8ScWsTCu3wNXfFBgOW39i0yJEsm74JmxOoDj3pGFcDHlPd7CRotUWXvzVQReRO55XbNK9YcN3FESE+yIBybsHe/a3P0qPiopNfYNgaX5hk5yuUfPUjihhdBvF0wFBGYCEUbAqNZrIEeHuTqn6v1qMYPujnQKGEB8FEpP87WWSHNq6po90Spv5GfK8shquU12SQGezZL0dk1Uxc0f5f1N3Itw4Cd8JDSiMhPAg3hCBx+pl7FohZSbx+YdJqnA4a8+phuVDAGKa71G9dWPVAaMTOHARbg13VBs7GB4YqtB+rjlq2f4dMjo86b+gseKZkB8RvbmdbP4588qeiVZ43frUqqDFCU8pQODvRZhC7kASJ27q685NBqCpEdhNFyZJV4RH+pZmQq/qXcxIDKBya1iTeH+yoE38kk8xDOoDgHic38Jt1wMMz8fJUTl+3kilUOs7W7K0YeSk5tNk/DQPinxpZKrsGmEM7Rq6KB1/OnX4RdsAw9c78GcThN3Imrdj2FhUCeBuCioyNvpqf1ZSsmiYFY9kS3w8IJu7BuWqdGTBkhRJTcOF3Lmf03wF5d6oT4ys7hibDeYvgFPFF5XwwaE7fAX/SBmnEGSCrZ8zQwsrQhmgfFvrqUv7WQHt2kDfmuPFcwAf0cVl6DYGNVGdLcpHB0rOfJ6mFZTl/HdFpfJubHZE6TihK6Ii/uwCoB/9b5pyXdSZBEzRT/Vpa/UcllLdrQYFvb20BcYkfOQWWhCfnjjAtHWxG+IT1fBCkTjKII2qBM5NArn4/PR7DU6/5QZGV+rrtn8lkNp9M4xHXyDgkGl881/AbgCgFIm4nKusyxVQ1llMKcpC+8ALVjWYIuvEAoPMXUf3TSkZiaqtzH1MOKH4Mq2dAiGgUtPfwkXqs5JEK0GInikTftGlNNFwLd71+hDTw+dwtemLuISlzzg2ar0lPILC6jkeMCcT5ki6Am4ZwEOAil3n++MCw+5y9QJOBX8iBdkhcZGU8gsZt0d4KMsk11RCT6+ZQ6h0UGf5I2iVhsSB9cCyrBbUrNmv0UP8/2sUTSOQRgRmUGwyLdjb8HoOpaybmqsZv+E4fGHZNwEAYeoqxIWJwGuLTqx29o+Ep19vML0uwCl4GRTYHL2zZ21Z0py+AuGZbcDdfW3Cwg4J8vtvaaADyu327deRcqbkiK4N8BKaN0GjGzgXciDE2zOjxXRwsNDaIVz1S8fQhWCCvRathORQMr4HamyFBQL8tefsGXz7gMEdioPf87xIcWhQ2EBCNxjLaL878rl/im2sV77tOle0GPHJNeCevaP0tR3iJhy7MvofS861+c+DwnzLUQRSozubxCoTR5VPXrETX841DGZs8os/L605QiQVnP1iHNWQJ0xv/lJ67cXh8n16xYqIPWuT1GcJLOXqJE3rKFAa8TWyBcC/6ootaBusm16ezlqh//Y5UYIYBlqvDZB4gWTiJ7C/C/YI1G8CdBOOELiAnVL0aD6qZ4CXHa8QRQ4hKcF0lDZQNIyivtDDNagd0jdwR7X9P/6N5dFiBIknZ12FngGcuYA0L+CmmefBil4SE+FiXMIy3fgCs3sNWGIWCYq4GazCT5/WHXq7+d8cDqiVzf3DgLIgjfA1EsepCnniwyqcacgsT9wF1Kvk0RM7l/WkVL7g4NdYjHj/WR80r+ftaaQCRAKbpQDhYXrnfTgZXoQ9+KFFY1k7/jN85uVnRcD6g4dMu0kqoS46+NG4AXtBSix60U2P8CRnYcpKXCHgs111YlijY82hkQRliSkWwTi5VhFSBU/enbXUSd4x/H6HUa4jkzgk2+QTAK2fAcSF54Pc883Q+udD81/ckiDRiF3bdSSRK+u3c85oM1q4MkSOH5WVHJnxg7wx7WPwLge2K4GewTNtSTsizW78Q7DBnQ4lDJJNR+70Ks8C4tBFIpsStHzUU4DSLjHjnI9mosb0pH/l4M4wvtV7Y4jFqjudIln/8B3mflQAUMUvt9nzsgUwvTbYQgQoir9EZL50XgR55dk+a/7/No4JG8eeo95SvDxWuRveXzHpUnU/xeNsoimbLFkyb9opKKGzyLc0ZHyWm59AXegHkPiaYDB2ZeG743zqIB+050sSvUixjyLudw6x91JH1cc2zTSPbctCShU2tn1PeLeJLQ7n9bPYrFylLSxJOGapNtdG5sFG8pyCuTdYOqIf7hEl1z4zNH+26Zx0d6Za7dGaU42dgDNSTcFJ/5BYuqssWN5MGRYme1ruYqO8jB+8l/w5LgL6LbUk0P64jWtqje4+jV4oHKu/NOpa0ZQ9nCicwLarzs6m+hvwVt6fA26FDvQJjppjDGx4sARypezZMBAEIZpIXVwxhuafn1nLHGU9Mu0sJ4wxjH1+ccoW0iA+Ekpzah+NoBAwLWD3EsktXIunjaDXCpIbOD+vQlqpoP34Z+nAZFsfjFouSWwx2uUp4z/8T31S9JwDHoCN89E1fIxfuQxyk9/TlKQqGgaUu+tq+q+uyDyplqkF2qKdQI2r16OB8B5PdolR8slH1rNwKo3Kk98Iuk8UFNAHjlHSZ6fhXjTNCulJCAwcO5tJRgY+VywVzHBOqd0mIHEajND/XA0gMyqgAgJoE4hCFA1CQpwJWu8RnW8csBBRRNCdZ31hUlIpC8phoccOtcLAYBHJvXB/vHYpf5rRwQeaLxJVTkNo8j9uupczOM0JbAGRbiDReHlWhDozGUUbETGIlkEPapX+llSGS/VS/OhB9hY/D/igfcIEI94aAUKBIEIJTuPbayeCwtqVMvV+Yyn/hvmVp6kl7b4lfTWmd8xxiD5ofBb6bMogGNBI4xxW04kSWNMdtFtxnawWKaIWHzma/+zfnsSEfO/TlipGMXEm72T2o17sNzW6tFUirzPWwAiZHKY9gsXOX4dpJSV61tb6X8/P13en0Vb5P8gvh5Z8sw87ca0QpoEuiCyUV8sVVZWKXXDnklcfqpt2H7Zvbxq/x2v48LYK5sd4MtzwVOwkUR7tBYpGqi51efxdE2pQ1yb38A4HnfJd1Tmhj2bjhFN4+zQVSlKk5uSc6WkPPdjSybMrMuTGHDKkrCJWgsL3D7w/mKQaiEmZrco/k5giVg3/rLa/v/qCT8Jy3BZQ9L5Cr9LJyGihwY3PnHKcrUgLWCRJeeRBJ5yO+b4w0yXnDg3uBsSMO/I/+skSJaAjAXRFtdqE62cF8v7V/4+0E/Y89LI8jKVsYY5NY84NiiGulQ3NQLBaHVg+BI1NGFVUOiYb+HGa+Mc8qsifU9/6U5KtAQH0itujzRu3aJlpCxChrYmaP4IzfIRsul/H26AYB2nbmjyem3qsl1x8HFmdeRuYyzIxg7S3oKgM9qMyD7Y9kPz7cybPCXzj4K+FmAlYgd9dUX9KwXNtd2h1n+5K1Zx+bi0diGd5e5AWdtqAYTQDp34pr0JcDrxtMDxC5uGxgS6MNit9JgLkesi+Qwcm86wYvJe1f0ln8tDWbGE4PBnDpLq+GqZBxZdUkdhZjXY1okbZirOhHaBtyMI2NkbtZaGbtIjIKW9LUrnO4VcFq0rh2BcQxfEw3wc/zfu/DIdRfpnYIzDT5wtSW3/CSU4/JglVBf0nd+Ki4b94Yf/jDMi2jupuhYkxOEJzE/anvrxkEJmto2mwCLnp7rCQTLZ/XWOw+0BrCXq48KE/lsiPMbbzEXs30HvJFKiQuI+OgSHvYiYP8C2Fq3fODxIDbrSgPGYwu/DJ8LElPUhOXOB8wg9UMHGzSdoR5NXLRqpfmJgKgv33zsGxNxiOzGFDFBuhxdUTDFbT5MQQri17rb4uPItan5hNwupNn3U9u4HmBVIRCPxBJlQEv5+t0JsETbykjze0dvQMFMALIab4KuwboLsO+y56c2TiUp3uQ8RVTDMaIYkZatphI6znUtY2dJIoUhvhslRPSzJhqTriVAx7JIjarOvBvtGrJFCpMqGcWQ7u+czZ8YJjESf9su1Lv5wCmsUKdhxiOroRlOGlmqZPneQmiG12Qyw2kaHAgCCYt7xzQ0+moAPZBT0/aNfOeW/nj/U5y9+fPfJHw4aN2GS1YxjhWLAv1MOzFrNlcL47SG1StTKC2ax4HVqCoePa0jBt5XeSG705ramU8i3FSljT5DB2D1wSoNPr2o+ddU1zFDzTXDd94yEO/OdaDwQisxUcVbAM7Vf0nr2SV/8v8WbTZc5MH8sfUpMpPwGf//SowEaFS805c2x81ZWVtXyPtdtnY5m/3nFyVGbE5ceK5xPUVSfgD0Hu8UIZmh0RevbFCFgQSXXUg1yIZmAr206fneW9dPQeiQHK055ClRATUNhOysz+xc0Ej+eJC1MRswDzyXc7qMEQJUCpvrktZr24SnC/05xVrgLGxchWW6Tn1eLwUJb1eNBK58gybjpxctI6JrzzgMNKEigLnKOBJ+gc4CrvBbWW5vO768JF/J4smeGkn+hR8Z3xPue8hec82TIc32Folfu8EJNWLFHQms0SXzWjf5nYIsV8JlQJl7a/ITJ3x/+bj6hQLm4FKKup8iNmEGTQF15nb6qi0vK3E3ocXeOSsY1H0CUAeuuL8reufi/F7OPxFliqhFn2ELoQLu/dyhBd0m1KIOZJKDZU/f7dSvcAFW2wXMlvuETwXdy6u6MEm7PKJ2O0oanxSFguSAyov5AW8MeyprCYy4173yC4lqd5Dl6KvAXkNJB+PS4YkB+ud5MzdNlEq5uHG3DZXqrytVwsl7ZJYi7oOc1ETnveRGcXn71yAYKecus1WThp/QW5pZuuAJHBCTKP/eEb4eVOPC/TjHnIjJG1dU1IZSSleQVDv8rwszZNkWWEl5xSJEI1HHIiFVvtgaiKnzxDU5KtPja8UuEe8+qgwITwitsfYkMVXt0WIJAZdchiRiIKW/KmZl/Q0rTm7ZwAmzBI6n0G+mzb9TNhEyh9faSa5O/7jDtIRFYWMPQCLwpsgZKcNjJNrz+VxODjXi8M1F9+DXsTfvZgBxPi4DH+Uzqci5Kd90AWOR5Ffc5MJ79bxw5v8y4QCb2EDdeTAQhQPijicl7SC9a3ONZh5bnMVxpDT6VOq4uteDtI9/4u/wNZsmTkq+KWxA+LZ6/6rE/+Y4Ip1Gwftl06KaqUJ4zTrt7wyEcMDLBwTTnZzvSWatJCNYl4puN9cv7wOVjXMv82qIH5bwUpHoveIRx6NgyAfR96b3NHOQUujM5Jb/8dq8vbg4+2n0JfbRYOHBqTlRPq2jqiTbuVSIPyyQTzcyMwDFDsW7u333XPRQTGYueNM/JLFuT8/3UiPtIWDepShP/f5Q8aNWYI9Q/ftDYd5XeuMS2oRJcXwd9HRjAKtVCwUveKf03SPDi6p3fP6eBDmt/Mtp2vrDy3euSwM/PW2NKuIedG4EF46rivGcEauk127HYo4fnVqw1V9TRW2Mj/bdLWfVpTBMVseaBr+v1EB50hm+IRqy5NDHNGcKODLYY8QbLwQa7RDhrl3luZRTCtgCtmnNg349KM/bpRt3cCm9Y1uC6g1NibZzNxUtCw0vJRZGw0n1ljNum59r0Z+n3q/u+h3NgvCtLF9knHCIUmCgXjUarHCefLh7m9SLDXIZdRmuUPtW3gSisMeuWw/jY2sjFCjMFkrmAgUtL2fWaEhLzPnwsIRFSBdOJdLppvUYNmNncEVyQL0D1W2byhBOZjzwpM73kQVNBvLrcueE4i0vtV7TOx1oax5Br1ycP+hLo/UF6mjXYkFLWfNyHPJbZu4H5tVAfqMpZMJv6axRdeajfT3n7gq3ADT7cpm4igIr8GX5d76I7Lybtwyu0zu0dojqYz0Drer/VfqOcf1+ZEopGBsgyh6IIEFGZ16jMJ/VpsCD8DcI9TvY++lrg2dSUD1GOQ0IF1pC2Y7yjQjeNFe90G3T59Qq8djFveqLQH+1ieF0Dzt05Rr5NCeZmgZvX7rKjKd7sRHOE2CMatRvBbP+J8KDTcgR33+jpe5tbL9Q4lLxeAuoQXLhG/ym2ywhXj6h2HSQzjn7xTsUEWWIo4APySiDNIjg6H5mWtuOqV1cCeVB+rjaxiqbZzxPbNU7/wC6+nOe8/6XMjlTjeUugviwjkpUUsPgysDzPtaOxcy40/QEMxYyHgzl7Z7/aAw7r5KQchQqdWsRGRWpFIc1V4uOfyrXpDG1yq3oF/BH1q7CVP1Wf1Tzf9DE5JVf1jW/jgVa8EijZGHlEAwoL2UhIcQB0E2HayeuVc0p4hJZMrhdNmVM6XSar6K92AqivcoFGZp7NdVhDCyKQLWcI4I3XIjEFgdLHk2CpRR+Kz63ukzxPcgantBxyWEUsyXCKntxwoFNse0/a8/gY++DwaoTjisYWJUNPmNyHGQLNNXpqk2TcBmulgTN53sya5hq+KT0G2rkHwNL6C9cOfThX/NlQEGk51uRavbSyHlMNCkqA2Cd12CxyWVLq9DxmXUn2xx6dNw3l3uWfyJ+L3AuyUiGdcvKzHNocDUjmjVy6T7rlnTBkOjerxukH+jOuAjvXJn4feHznMc4NsV97F7qbD2N7OPuNwfluOL6DpPl6cFOxUEqZisk7zwL0a371LV3anQCFGdLoPVpyj5e8obBxdM0Qq6N1u6omfPtZ+wyXxfHLJhFC3tW/LMZkNlx7M0JhuJjTUxgtNEVi+5v2EBnggqWWAy+FIT188FRIPD/GOULZlh8cRcKpC1VC63rHOrJP/f1N/OEneDK0GBOcPNu4H6ROSqsAv8HNNebCQI3CT0v/lFiQMHFnnBxu2dtMXivcr4sWwUPZls4K90kQ488i6GqaKwU771R5bJtnEiTXa1lbCA9p5H9KFImfPyoQNiolAknEJd7xafnbxdIbrf1LGLZpWYfd3qbm9HzBgvxFokaIO6I5izFPmrwkEYtwajdUuzxeBVdXmCkBJ0CM+l26OWCxzRsjCHE1Q16bXPLBvfL6PDerQ4Th10ABxF8xjLumQIak/g4dV6SFGLV2M8DgImyjzkwqpm7d+goBSX2zrOOjIpWj9z1b+/cSweHGdv4WAXPiBEQ7Zomjlai7GY1A4ZmU9L1Qv1nweWfcSTH9IsNxgrbx7fiZIU3tLQKWzEFilwT6bpY2ZZGuCkKs4h7lmwENqmJY3Gz+Kg6Kpth/j3tIep1TMakXwwKkxO9uQ2uihPwu9GIWD/gwwUeahr4FSotLrS7Xg3BUjg9bMw7q/aRdPatMXj7zuASTZPoyUJxtyMMq4cJp9LzQQFzB7yYljzg0/P2V8tdARGTMd5TvoO7gPdLPqOrP//QOaj7xGtv02SSWpllUpbMobVIkXjKV62j50DLV22KM+ORoaZPuY62jK1c1pW+9nFk2jjUH0pt/wdtfCECLskuviJcFSEzJtbaWkB89OZ6lp58WI0bJyaoSBXie8jvZMaKsg3PbfnPh+yWaqOJt1J03JH+4FV8u+nmnwZ8vpMF3lzhmjorVOJM7Om+YAm07cbDy4ckqVRcbvj3VIUEW4c6nQoIohqktKFd1Z3T9Syo13cu9/FmICSeYy+yotgtZ0rCAJQI1Oxo6+V9GV0oCf2SIn2iwrrQvvAhfg5TjLd0mHJJ2VxoUrQYlcNkLI01ir2xJYfNcduJpQFqxBC/UR33bMpp16Mo7O/FpIstcEgElY2p9J8UiIA6r5FWYQxev0oF/wSfWUruoHE/N0BWwtTub7Qd1Q9tcTnCPez632gIdM4tVOXWz5Cfu/FRQHBiLnZhUWDGC4oLFjboXH7mCWgcTb0JBWGpDjUUb5Fl6fd7tz72EmZLdyoTFGZ9Sw1W+Wrx4sMq6j0gujrwYTUKjwVQMQ2DaNi2p6Os0dXWlDlUuVmsAhhBYOUatJCk1RGCiPkE0p3b7rbiGUUFMyPoXyYyz3CVz6VsbdOVamYWaCFOnb83RPCmxRii4zKEOr1Cre+kB8aP6Ppw/H31WzLnSPYDbaEyAil175UMDeS0O1pyBKfBhsxZ/r7vfLSfeUSrhBPqwhR2susr07192gfB9XO0hFOfTBvgVSLOXuBMbHkqKNqhYTdgEl2B8Lt+HaPkQ6OVOX0Csr0FZ44JUEGbrRrqT7ZilKBQAiY5xdt5lhm/xr3pQz/Gu753pxoTSDbvNC0JJzxZixz401+gPxtQbjNFTEmSOgLwE7AzADA7SS8fTB2bjXXbjAkp/bWD6Lj1dfXhKqrRa6KZTYUeqRox4yjiXDSZy1XfgyjgzKhrlaejxwv0Vb2WTmKC/o40JTiC8MUS3cum3VkFlSzEMTslUK0FKytfVLrcBfmLdWqF6YwydOVUdAK6OYYFJTl2zXsw2E9E+4VIZkBelHnqMrchvnBHLSGXvF7nuAlo3vsmztVWq2aTuJflgDgHbXnSGKOgNpchO1VnhbZ+JmZw3tv7D6672v66uezAJh1dqfqSsGA9elcxNd0+bd0X+K7sWLVaGA7AQkEwD4XLn0DP1jvpDgfJBZiUyrDDP1ylVtVsN7Hx0EZJgRJ/jqVaH5zOiJuxf9dXVeiAPQQ4ulTPmmgqtCypBLyIkN8qtt4ph8vLjMBhSTPAJSdGGCa0CvVjVEGsKrHB/hkD9WlWyEbEmdJEU68FcbrGx+jEnIkiQXlpPRYmnoEO0YKS1W6rHhqzff+Rr7kIby6qyUiWEH9ZUf8z176CYbqFdXQAxcrL9mfDlpjjCKpUaszDYgs3jFP0Yec0biCjKd0BOVQ4/RdiJS4eEh4lcdJsBm3g1sUX2GNgGqZ6Rdb7tQumIf8XhbnWnYoS1gBAEIBRHunuM0ZE02MReouIF30pc16CNb9M9UUdZfCbQcrix4eaoJZDTE4pA6FO5EpAb8tU7paZUTzLDX+5Ke8dKSG8zn2fEy9S//FOCT0ysjl3X0Z4tbS2lITN/KumXoKD6ts6+erZyi8KxOe/aCvqjeuCzz3PVYviRqBE6cjtwFIvTdxQyf771OAyz3SHEOwBD3cS1PFjsOc6ChPI4Mk+MP4AzsoZcO/6PGdlGDCboeXhYcIJvhIadgJEdGgd/oSxa3lPc32HwhFOIcLpaxQbImK/neLc1AFtuabdrlvvhurxtOqNtdsKrlVm1QQs3NEu2hA9tJGZFkxpdBvED7H+WzgY8pCmg+dgU33nTyL2mQ0DEB81+YEl1y86wfQEQAa/qlvM/8ZcR9sw3X454RyMMxknzI7n/vFNwMlJLEToWXKEm4wRLAKJn8lDLWP3Ggb6vYvukQId0X/hysKfW3VafMxm3pAYOz+0PO9urbWMJYOgFqqnByUW4PgfBBB8A+7dkyMP6CDT92EiKZBsBoyaQU7hPKXhMcMqRZInFkkzKEi9OAlRmNBxV0IUJxL6E7bZYpdaPfRPVAToLNg1/BodGrzbu5wbHO4cPrcQenjCDj97rjqx5VmcF9GhOE92iq3WQd3ns2D6LCQbUsOfcuchzQu0AZB/0rRMfl3OPca8wf53CDDpXZCvVc6+/qfcw6Mt3ORKBa01NAl6gF32rexYWmuGjCiUG2Bb7YyISb3wJb8KRpN7r6gi2dw4rq1EjQGFNe3S8TGInKgIaoOiPRNHnDzyyjDs7q76+IPE9kSteojwrdSJyEhrLL/H7oXFl9LFNpGuxkAz7gSuAU+nQ13ERMiTmkOgthPS0u/ZKy8Llvu6CPYAqSLlzS9ugHtYBpsjyQzNjHDtGl1n1g3op8jPPYZfkXEpM9OWVY1KB/14UHL3i8VcC0+JJO46kgt7h5v9uJMF7hPFLhWTpUfUx4oen0XylaktQNUiigOGhr1gc4pl0HoZxwPcu+LV9ZSvH8rU/OykF0lWx5Q33KiOj5h2R99RkhJd8RoVZUBIZUE/wMaxzDUJbNF0DE8tI4YN38my58JI2Pw886RLLEBi8tcM+0R/k0pIF28w+8EkPP7/h3qdFD/HBXCtI5O4uTRI2rp2UCgpojIl437dGCePip28c+sKqdM7gz3isACqUxpX+0dZ5OEQeWfLS2CPxTkCxhtonERWpLOPdZnLL1RdpTj2eZ28ZAqIBIuTi8D7w0cZem1cB3yXqK1mKcJGwsh1IkXYZNHLnMIqKfP13oMgAQ09JLhzAWmVz/QqyLDA8AnszQ8iBaoGpwUWgMUvWyyV4g1azGE1Gw/8X3dKDlvwXui+vZTLIWYA9lVTikfedMdRvCzx/INdjmL0OaG09f2bAnA2xo5IkLoPML1phEm3VBbIU3TEIXHxz66vaabGRyHXGm9VQZ5pfozcIY509oHzBtQU8thoExWS0pz5pPPooA6AGPq6IToGy3RSJzeWxr+jgvht8m5wyfRpOUEA4NgKdM85nWDiSxcHTO7dqREQejLAslTJ/P/IwDTadkJJzQypPw1mYHEYLWUZnYHc9bWmnO4FV7YL8TGWni2ghw71YIovao8stktuAhJHD3S2RLdivrVOSWtXur+EuIQiq6t2YxBvvUfQw148aymdvT6nBEztuCAYDbeCO+KYaIX76ICutqwgH+BqjOLszV+moc+ivrqCEfRi9VOfIEn1OW8wyDOI3i7XJgNcn3XzSVXuhGSmPSixcGrPbagMrxBb4J87LOPxvxeniv9w+FpSnZGd+5Lhcan4yxP139/qyrnvyiwfE1o//Qs9SwZTlfaCVr2Y69ZY7WyzsjxMZ6FzMKr0NWbBgNflo+VE/XRw3kfXMyoIqY3Vq/BUa5ugIAs9OcMCab1u6vGV72PV846/L1uGvxaqdeeRnX12TUVbb8J2Ce1SSQAhGr4fOwF4UuPefjA4dzw6YU1HOLTpkzFcfMJOQN4iG+4sy7BayREK8G8TioOu45i57OqObOprUBfECvySrHjHB/PMLdkXgF4wwS4oDNqvTPyi4pWgrwQZlcHs1QqwpsPkJZUAuIXoAHXkL/lG4Of7I3Uf830CUktdvDSwbp+z3yN8+lvCL36UsCmPEd7UH8aaRytytNEvVbWyPoWoW7e1mnxGbGbw8FQ6x1DONmiRiBj3tGJthBSyVIVzvIvG7cqgs9CJOf0mVJ5kFM22YAYg8j4w/nJSa40/ueYyVl32m70XqN6oUJoxujnOxN0HHDrdydKI3eS7IG3BxutQao+xwi8icR/o2DOfVbjz8dnFAtdsfLQ5tk/24iWVUr6pEDXi3bMzcAmOVbhDHB9EbUIEZmA57f844StgRTwzwzZf53SFE0LilYcASGGzJkyrfwMm1jArR+mx5QIZWnJt6cWOzj4QLGl1lGhXKbfEfgv+Uj17+Ab6vqw4j06sKf3E5B7JPjgP0Z04Mym9UOzApsymQ58zLngkPSsw0AhWt8Z9WQOMtuQSsmAeNTTZ5NUqN4PcfyN18pbUe5LgC4yxNO/AgwP8xC4pGxdeJ1z43ts3S2h6Qz6Aeqc/zxky71P+jslk4D6XTuO0Hucp+JJmoYzeKeGihw5Ic8vRa9Mfynxapm7SihTmIWUElw+drFht+oKEGjs2LAUIWdYAvEcwzGfk1oUquh51Ao95amdnJmY9lXMhKby83WZH99eePuiPxzh8PhtaUVXJRJ22etd7SlzDuMQkzA4vpEJOSQMM8FkAslYgzHgZ9q4yMpUIAdTFcTBc70gBNrZ1RzRvW7p1chpK7/2PFfI9deY+ub5QLKwHNT98lMKDNwmHeYFuWG8GUcR0P3SKW+Iwc460KgfEdqrO+DtrD1gVP7UPPQfabDxKQSoPodvsef3vjQ7rY+j19Igb++Gj98Wu7eCKQ3n3SH+uh9nvoo5gv+nXuKZvPVK6CDHGKQPZAagKfS2Z3Nnyfu7HrSMAfYL1GlfJGJbxzEcTh2F1g0q4ZwPU7Eg/trEeGBxBT+/NcIEKWK4jkiDgvpBbSG3STIfrrPHzAMR+oxp12Ylf/qOT13UdOWWF5Dfzt28wTJp81pFYD/z/7ENK3n2az4mroc/2s0mduDbl5jCt30Bz77LMIXvNXhVbkz9zia/sIDXZjdLj+KAeWFHDrpEm5SoB2ASYri8njL8rCGPEmKeOJW2iykh0xdxSOHeq/BKfBBLPZqzmfMo9fopuM/GeQxhnxnn3+DCkk5DR3fZmjJr4GCe8Gz8Z1KsfQJvbc9rthU70e8T3eB7OdXkTYLfUy0frGelODJFc1Hd51fjkazFWw35XTmICwKpcjROlSn1brYrA0NWIPjzSMG8iT2wc7zXXTIyr2TVduIxq/NeJ+ss73ZtxluurSFPbmJbIwwsIlUAVjCXSs3RxWkryJ1yzGs6p43sAlaeOgfyTIkJkQE2sIlXap0VkeXPzK/4/8wptromp+BAtbsaMrvoV/RS9KCeUyzGu0dAv3yWtG7CEJSh957nPHiPGIUvqVrtaxBeovcqnVo5hZjhGU4L/LG3NrLv2EVGld9CuX3ZWHIC2aKTq8+qtovd8U94jYk26RacvHpr5kybIDPueSOXRYP/VvfuphdRRLa1q248qOFh/PCAiBg7rco8ndPVxjF5sKAa/xLpRbDzmpH0DcBgtVmN+fPBFhACznRhKZMeVrpJSSGfPsJASpmVaCWQmzNhEFzn0+zc3xarPhEOkC/4tzZ56dhlv9/3fTIWW0N0fb63xapoCWIR1PQGhV0qc1rswhtYHA0njVYJsbai8Qikv/qcSX1XmbttNSofKstDkvflrVYeN6WY7cjqKAKVg3nUHmrx1v5v3TSEV/S9ZJoieJ3lIGrg5Aq/PXRn1RX36TkTRDUGrxwsLQBqwxNQLR+a1lpLaYwgO8TsHyg3hgIuTWiBk9LUysiFZDdr9VQrX+bY6AltVlwm6mUJ3dNIRoEvci+VAFynSdBJ4fNoMy8wUu0oixeXeCX/tSKef3qILUpv1xp+hQVIwxrUSVIhMjJQHNo3mwDMpLm7wxJH4oC3N1/Ad8IMu/rb8ll2kCZvFhfGOaCIvqBSnQQc7mLvXQuDG7eUSXOoG3GS2IUSB/wyOgaiRkCI3QfFYNWdMpfUpXqJvt6w9zwz2OcRPy09QDYefNcBad7w3D6JP5VMvvmO3oDAMD/Ph3OUmdK1Kj5E60ZhQUrtSThO15BTckyVRxoAXj2+vA8GREvyKcCJ1nkXM16zwzo8ANvZjIONynKBuLwVuaaumTJLjJCkDjUbI1AUXnro5niBjBjYpU3UcYi2DgbuAhk5b+k1uk+w/Ymn2/RhLiYg4DGssRm8PJbpH12wnYf+KvSC/04zAMxzaezzMSiCtJhFqiGtd19lOQVKbgsU5ix5O1P8tdlWPFSmJa1ClUIxvN9pZEskbB9cSh0vsNE5S7Vkaq2glPR3ne77hXrsJLC3/Hv1CSiTHEA93lhIT9NbRZswu7NGImOa1xOoPg/G47UDB7CoPpMIV4MenrzsWI5fCf0UAJJXxCmkBMxAHQGXYjVOTZGHgBm4TB3YvIH1M8X7QRBSFae3sa/ZKHpBPEv1u2NK5e1ehIMg2QKt3KnCu2FHzBpIh1jdfJ3U5s1fnN5MJh4HZmwC/M4NpmIhd465K6Uksjd0Akq8J+On/JHHFEJ1b5JW9YLkRkeiLA5jQuI+FapMpiIqx5whAUk8SWviy+M3cObVKK+EvCHz0UavbCzbXUYMWISAk6RmNi1JiSGVEG9DHshQmy3so/ZjBfmN2IappPR2wDwklrtjVQ8gdzVyql2RfUSQTfXETwupQaW0Swdxifm/zLi8LtvBuZjz1tfFOpHRzInDpHUL4fT9mSi6kQc0jIYNoAUnRLTZcTNtvjQb/fikJ/syW6D94AjnZPy5eX7PEx+B6dfd9z1ERMBtQ8excsPmNAbYf0ifmC5oYXD8PGlmNDPl6COZu1FNU2Ori4ifK1/++qQUnH8Aao6c6LJemRCU2J0wGVqhhGo7oTYVAPPLO9bJkWHXbNXrvaqAgoVEm9cYbQHtDForWP6v1Cj3X6ggNjPEKpwJRgg54dwBMCu7JNLqPvwsOElK9mSbCMJp4ZMmVESm3CtBWmbdk0Q+B1mNz/t4b14kdAHjeohUC/EhP2wLypfrmR2E3TTLYX6O5rfsoyzFIjjglvDeXKGj9ZX5fchuBuqAJS3jaoeTGqcrJW7Jc/emfdRFb9aCAsI+WOD0NQQ7nGO8immc2XkYYC7Hy1qqaf3iGoGrOzQIu05ymlvt6JqopBm08pynGb/UakWSybPzexRdAkWrewJBNbX5BYFtNfTMpCqP4MXct+j0DMO61HzE6VeejprpsVxycdPqZl86EqdBkCCT+g+jezC+laNzCjeCpCDRNUeNf0vH5V9a31sYb+PAeUgp9dqE1tyd/fejyY7R7ZgHtTVr7h9rXPxxypiPpVNLtZqhWXOnM3kUFarD9GygPrnVaZycpBAQaUkd0JNGxCrkdDSJIx4vAkkX+mB0H4MKrWyKJJSDJapmEoW6GgMZxbnm3m8klxBQjnXlbUNwxchSHvZPbcv4irzR283nwcTXUOs/ueGgXuNa0yRnDJDkDvgsvv7dQKeeqX4a8UQxR2wlRteDwupsRCYbSgHqYTRiT7p5jshsYKrLaaBb1YIqdKxAMO3PAI67rscLOva24SBJXIwPDrzPZvX1NWL6SiXcZtT9nwHOR4VEGkaCrOP4LhxUmOd1EvGd2uZX225fqEfyeCtLFED2tNUt4//MzbTQDkMoPSa127fih8ak12TEfSas2KofDUJWIhtMZJ/0M/b2IGZMEqoCWzWersk/K/Fb+l2PqteuPQdJyCOYFs95ZS8JObtC98g5uQQ/1GwVIHex/UkB1dbCP034jzisdkOiaWTahQhDp2tVnt0G78lkTzGYdOoMrHwZH0T6Mmulp4m4kt03I1t8GeMAaOKyqm6cxMYZyuLVnSLWLABN5P9rNIK08+HxsLvH/D8vDrlVdv63P4i7yldvB8ar9w9BgYCdOr9Pfm0NgeZ/7GW3WE1XF7Cj/0YgeTNvjsuVvFH5N1/TaDIup9YD91/rMio81/N/BM9ORoeYy5QPXHUt8wcN/T35soQwSytxRX3QUz4BTIRX0CakWVzC3Qgc1ZBeNRYUxja3x+xNnS8uHxABAXT0YzVqZCvl0WqmQ5Z9Lhq9oF5t0grICKx3pPUahzbIt4KMQTE9xoo40AT0gCEw7I6REfoeQ9OUMHu5v61Yl7qL5Z0oC88GRyz2J8R0wthwDeKEsWcaayA9LlTIhOZOoVEjJPKDNVI1ESxfxvuIoNhIVJ4Y8Cr0pnUoIFN5Fwk/kfTUyNfajl5G/RneHc4+3LEdXU7dn2VNuOvo3HrBJuN2GAK6Z9f+sBsObwOXmp8UI1FTgrSRrgIfICn0nNfIQAQHhHem7uYmvGaOF3FJGtrut1wdPF+c5T6QW5Oj0bx7EnkeaOjdNaZ4iqMsA38nS+5GuTVFk0xO+8VjD3DsejXFV3twUC4NGVpbyp8o06iPlL0bbCJqgLffoDGX3nN5rjUQU3bskhgNH4Ory0iahpbNqepsNmqUWiHM+a1FJFM0F2rxSL7SI0X9pQja6r84XYiO11U7LWUr07ZKs9P0QB7hc6V9bHo1eL6NJKfPYSwbkXMPVYJRlBprxSnizeN46gd5YfR3GduXveoSUVrCPJq1Ik3OONwewnaNw0LZWsg1vXg+8Vcm4lAxdfXcOxdi6lc1pq/tGtK6SPEkJkg8nvnx813jGAQm53+jwM6d2Ix9o6snvDxW+grsMD3wbME+I2ohmH/mx+pRdXr1ltNXrMtW59J3lx64C5JfpJ/JFTub6xFtLfCZs8ZYoRhWuaw+dQATsjsaTzf8Tg4Ze0bGXfwnWiHGhgalAqvjrDwA7ktmSwa2lgQyd39B4uY4NNS4XT4GrC7e/cnR09yKTN4j9fMsEFFebSDNm6AIeJXna18gfhdjOsD/w6IjgE8rjNgZHgZNhIewy4LAz40A7qiSQHaPg8cVCwqXHYatYS54cwBl9wsALx4PO9vBLDyO10m0SKzI0mfRl70wo4P8jKDObB4ogGKhowjcRZTkQD/nlF03XLe/zIHVbzLkKSzld6SjwPAlWf43YvJctsPkUZTNzogYpI9BuOjexEmtGSjMb18aLmTkPeCJTzzQ8xfMC2ap+h5CmUDnQAPR9uFL5D6am08wd8JSukFjJafXOLfNs72VfHbpq+S8ZWR8MCc0qhVQ2H5dqIDMRZa8obEYh1wIMCH8ktr3OBwZU3Q/nOfW4uFQZJi+untzAeLOUi3iuLfXRa/a2PtICWfqrL1E8+ToIoWQL8vrvkYQ3UXYX3aRP32ltpPxBVNk/risbtokp3VYER3hjSl/D0KLHJ5FpFvVcywugqJQZQG47JfJBdt7xs6VDW14vlGLEXoiXJd8SrzsalBmREnO1cc4+mLvCi3xRD8tDu9K0+8J1SjS55jsbxua2doSdao0O8DEjkWG68VXnJr1X/mqVIZpor3TOka1UpIVYMmwnnh0Tm+rwJ7knKWAf6WEw+kFXOs8mssXLQqXl6eEb1OjkO4OsAc26y6GUlu4bJrdyW9Bb4BKSFC5M6pxdXLfjeyVl8y+s5oqt/V/H1nFrothYiUo0HIFcY9SEs7iHi2q5n/4Q+pohoHj46352RWGIROntFk/DQ0SGwmXC54i/FGSIwJCkR5msy8+fGsF6HSIcVcqvxympKtpSorCnDuWdebp8jz0RUC9BvjESNmrnNe877FkZOtHWCQSGDq3SUILswG+FNSrZ+Cf+8+9o5ROJ8RjR4mshTSlElbC5jGh36jTok0/yCFRRcrurgJMyMjev+hvzMp/Mfy7+Fyv/jveL/8cUy4JjFkXm36gSHvzF+ISE5ZLCKo4F18JhNmk8r7Qk2AJaYl45disd+W7TZkRU30gm7wNe27FtinXwOavAkpMGc1f2/3FSMBE7vUk+5AcuUz26Jtp1clKPvnjU5kp5g26W+mjDyy4sS7sIe3aqh27Qr3suSQy1ljHT2+EJ6gswELbq5/5VI7xhbz0aRM9q75XPHHd9W/I1R8JRQ70FnBUwdhL9vJaeATH9CVC19oTWeIbDb/hwOfHHkAEP+gK+oMS2dvLWDb2R4xnLB0hcEyBmSXJgCZz3Esl883MgyGJ7yYPY6qJxKlvQ0AgiZfi/P//QHNeitHZVMCOXWLQ5McZX8X0evIWmlHcVoqtW2gKk7sMmC7xrfAfUCWbi4NB0jCDOVWjfahnRRnraR6j44dM/8tzm1kT44uCUl2fkaS3fUZQGsT4jZBMbpFcgm+QEb2+iul42TDyKQC2wPtOFNQdR+8MDzsXQgjaUGwsjkYTbkGMmHnnBzrkIx5fYVirhSxepTKcDYvS0xZgqW4iT6twuHg0vo3JLCIlaaLGl7uAptLLFr0thrm0U02ef8TT+h2uDbT23Nw0VOAXjncexCa93095PX79GK7dW7GlG38Mt9HfRUA/jtOYrPhqtsZbxzEaZlD3vq4k9acO8Al9mKLSb4w1oREh63W5LDoOehkALKEQMMnV8sbVq9nQDyyfZmFIRhBt771vmJI/vkvTzDe4qXeE03ZBn3RmBWh0U+oGoNGPVKEKyJsmRp6XRDkZcCThMGfJ8ZYoTDMAjgC9ty6uVmhenC34kAh2WBUXZP3An4aU3ynsecCoj2TOpusX8DW8cQE+9ccOTL5ywA++DaRlROFzCXhXlPZfDJiLhf6qulXDnIXUk7/ClTUnjsvW6P9D/4ha+Iloxkc+WUQ3ybEBsVulc6bqzKf2KjHur3YJRK/PB7320wKA8f/P7cbA4acb2sIn0d7o6UisKedJjPhsLIniJ5nGShVksZDC77JeEmllX/rR3d9pXuc31KSQWYM0yhMeTTod7kZ8rtmB69S1u8+MGuWADxw91iM1EaxQ+Yvdww4DRTC84b4r5746QxMdpd9EJ9cX38bOqjoNojJA2WIWAzIC3vYk+sTLnH/mS67e7NZlSmKmijRJilxBnWHw0ibdLe6TKWdLgMe4lncA8vI2eL6tQWfqCjJBf2Xsbfs4topLFC2JBKcOI2IlFN9ro5+HNRYZ1EcBd7zfgIIjfP0yV+xjI1Tg9RWooI6NPdxptEWTGJeJ8rwsXAbTqqnWi6/M/s2fNCJsxMjJdGO2EDaeWMWHSnRSIIZki76aoYpMYmg9knWZ1vH7IzPVu5zFrfKtHR0nJynit0vRm/gi4I+eriTPOMeRF/kNaMvmJ0M/FRExO2R/EedJvJ0VSlh9Wl0XfP53hG+KuIR+lWU1HzKQ1d9dMBt3L7bI0HWa9tbZlT4rXkliN7jPgUoBcoQTg2G5IYuSU3IWplIq0zAk9pQ8Uva2VSWU9awTQu/3L6cvqd7U+wD4iX2UwdkgrM/GvD5pjgAge26g6+XvGjfnbA4HZvSolHScHafuyal1JqU2zhxsT6wOjldjtLxfJAiclsZYUCSQdrVPhT+b/mUDncPVMBNo+5C/jPzd++hG1OblMrM2xrV7mEQYTFs9FGBJ3jgUuS+u2HhZF3BQmdrCcgtYfVcUUJLdxm0LGSvX8kHx2wa9y/TkJKbgG+WpB1J9GtI6u9jJ3WW4KxnQZshGQB3ETtJhmP0MSuL4e3aXzysj96/a22jRJ7H4FUHUWZSg2IH/9N63MqE+2iP7SnYCSyzEXsh9i2vvJMmQFGXHwrqm4CgAr9El0NPjBYe7eurZ2K/+4HVMlBg6YI2/STOKgqe6E5D6OIq9iMhZ2mPKf47RPLu17H+EQ5nKrU0qIifGGdAuAoFsQnCk0Sfsg07ptrN2Xd9/EnrAFxSUOuCg0vCSFxfKLMjBY5lRtZtXDqs2z9x4wD69hFB0+QORah8DS8Qwzkpo3zosMVO6j3s45sTjv2Pre1ONmsQ7Rj7fRJiHNY45CH00crdPLNk+dmN+zI7SQAoQ/PUALdQTJT8Eg2Qz+AxSZ3/3F3Jz33fd8ZIfooCA9X1ZsYvZe5r7QJ0SpYfuEBE6TYJk11zBlBLWwHpvZdNmmyQNtsWG6OsZ4XgJenYw5ONu5FRZoPcSQ0ZRuW+nLjLnyCsPwtn50796j+64mBqwNbd1CkNAVnmJX7M3mB2MZDAI8D9tZgySKGZUJXHDa7Tl1W8f8x92ltp6vPVhnIltvBiewbrRG0gDS2rlJ2MLuhtFkOKOan7Vg68rI2z6ogE4Q/T0+UcjeASMGUvVoqW77+yiDVa25RdKRFu2zW4FjHRSS0soKnZWb/e5Igw2/FjmsOQTZYqObezFSRnb79Wb5Daeap2i3hg44KZx3twjo1/4e4K1czqoBtiDC4JJufJ734qDK2g6r4pez/6NnjRMdxya1PRXENoVW39AC8M5AVxpAL5MemSFhDaXLEg0W213TU0+V2tOzPl4Lfltgn6Z/15Y8v9SPaQLW1K+93E8Kh61PJO+KDs919Nv22ixFO0juAZKiaBR765f7pgMoT6dHPGT2hCZItoL73Nbt6/qwAk9tVzT0zGorJ3kwHbJMEqr1Kt7MMbSjnWdgTkCbDZBJomhnaJUdwr75J0RFip7gxT7mkKLIzmQIYISQRumgFcnwKblffJxO6r46Djt3iunBP+vrk2DFGtM/ivK5W+hDMJZRg7XT5dV59epJwJGp/nAYd841z/2K7oaz/HaYuBRcRNtirTsdIdkg4zv/vzZ3mHPupjY7j8N0Z6eLbx4lF9zz1zEzJQsbvrfVsXMaIcRvlUNx2yZtIOZ8plAb53cEYAcGoYk7ZVevme0rrCuwbClM4hw7SaZ5ZuxpNQ0o1MAgIezdn0HK7zzU82Pn2jHj7SpuVQ4GESxOEPZvEYlpiGDGhPypCX1OCKTPQ1cjbwon7FU+EdWXwEK+tmZIVmJSVRLinvRufysBqMfuERtixacn9A3lMWbOy+X6l25Cpr9OCaJT1TLI5rVk3iTl8Yr4Hn0NZ/3CKwnPW22gC+//zYYgJwgU7RSAt3bwq0OXLefVhSQaAe8Vl0hdxDXMms9OzBht+yqiYoG4d1jSQBZev7Hva6eMRx3VoLTi41s7JvaszyeuriAC2PugpoCpC/sYOZIRZ6CoLYvRjWhaS5NtywRbbE4jlySGP60mXyH6BDLUXu0oCC32h/fJlf1Tvi5t2tvszRxtFVy/hS3j9PgdmdoKnWtcrKx73IUzD3QjQxEETO6MSqrIcbSscRpLq/ioEvFeh3qAITs4vn5qb+T43uiUvi+uh9/qLNu6/sNGPq8Zffgke9egztq8XuGjRNN44cGbFPXB4rV16EudiOYDZ7a+hSPp6L4LpPdw6CG2DVsvIIKr3ARj6Pt3kIYgWyb9k79roaQVptZI/mC5uFmWxAYamx3Qf+VOe1a4ZMW+SmQgfYrWr2YYhLpmNjYOHIRQBvYslpwmXBaQJXBJLqvPEHXxX5nwW0TvqTOn4GFhfzpluAMyc0Iou7iP7QW/LcfD7dr+QycGoTeA0f4BooKwr4Uv5yGLDNwcQbmMcpq1X0t985/FhqkeQZuog/2OCXCJnC0PTivQd7aGFCGZ5mI36cEZIYMJVLM22lREcKuKV/+WwC9KuHVR5CtDgeDLOHY08HbhZjrfbDe3zvJ8GkmDnMBqEfjuOcIjnjTSGsVvTVt5Tjdfk9/uinxRuxzaNjq4wZGN0hvAA1Ixqi+4cQ85MMCFHpdQiGShydn0F2ar5DknGpRsqxJmMyBBpn8RGifZjsnKvB/17/jcpeyw1k/lmcc2oVAY7JuGHtpdmOoBVFE5SvnfjMmArjtt7nqQEA442//p8dyYPl2zhRL7aH6zxo4v7bpPpS0xWSMT7+28YeLn8tKffKDB8xSzFBbz3wsnrPAbNk4VCNAwFP26bXUrvMu60OOZv8PAmE30JTKQpNqEASlugnPPwGKj0rQsRFjztOvYffnjBqu9UrswYvQoAo5BRH8iYOlwj2GEXC/if1NnNRbZWFQkmURvd4SV3PlPCJlX/z+WrJqNnVFRgY0mKtFwbtqMwJeE9ZoBFaPf6gUyyxPlvf41EvMFoihwif+CcPQhdlm6eVeHz/TKca+HEjxV8/U3jPIDTj9m6b2VdwdrGW+TNCwVuG68XDXcIk7664DScMM7SsKHDHvYQ3iL1SdCuwTelNleeHJHuEBrazUFaG0ecHXKPlKWt8p4qvcfBCOhgGRtAqla/ClAhNtMeITVkw1MtvOt+DCIpSLPJwcT0nB+ikXbBjI3IrEPS3tGCFBDX3HoyVXCKtQbj/9WfLt5DaWCLIGDS+eTSRN3ej7oeP8Emz4F4MUtq1Tg1niG85OUjZoWM451MYC1uWzNlRx/OUfAmEAdOuTzNGWnuInacRRu3fYROEwCwsT8JNlubIAYC2g2nk/IfB9jkg/gLfkz4A8W+aPZfO+y6tyXEwAW0suhacvXhiixDlxQAj1Pvh6MmiKcgVC7qnareKTbNQ1MzrRJLrmpEiveevNSL7tnRApEhJnXVgYj10gnJhrwZo4By6REvQpxQAGKsb0z18YYSkBD2jSDGfFEG1xCYT7ZVzEC/w3jsKFQfgFHx+UgA01VjeTcMpmHN1af+OhyGGDCjPSTECyYqLgM8WmD18G4PMaLLZ//qhdVwR+e43jbUilebCH8CbiKH/CZRUXJux+V70qFRFM3jmUUdKoE1xRr8AhMdXUi5OzaQIxQP3jgNGiCIQZjFN3fcgdULaSA/eN0mULwmfOZ0EKgH8V1o1CZwdgu8v8WbPSyYcy+mgCFTMb48eTboKYNSxHLV69GAoQX3wZ+YkAVLDx/fkGuJw60jINbEXGchdr0D/oqlkQUfZMxiQlJC61oftjuvLn2kbxusAKpLQ/u4hfULLyrTVCOb6j+NdLCR14JNVulUVNxstRxs3yZDx3dROgeQ1c9fo9+RLl/zn6gulipHCCa7hHkrSNhCR5JiIG63+fxVUsuczJ3hbj32FiYVaXxR5MACjYISP8r1zzqD5zaCdx55XbC5WowxxzmSBjgWZVC8qGskBAilCwTFNr3epufcEZ0awI6FzvblCa1qYSODDWbR68lSazncP97q795R1wDuJKrka4OluGTDPEjbePP28sm2u2VUBdlnKXPw1taUJnOgD2t5mhznu18p95mUSRWI6Qab3jQ62NA8FciaCBrpz3HKvi8nE9aAf1M4x5uP8Eg5dRbZgn8qGWEc9ywK1koXlCN5TOGnBD+8hs0byLP9mnK0kVTP61bI9DMYejmbrptJiaWSlUDKNUU+A97iQwM2u/n/OL7GodRdISs8hnIx4uWMmthCevFNvI+3DoSHLfs63AtU23zjv41CL+iTMAjiD46LsuFwqewLwKO/7OLwz5SYavXhvkY6qflNGfdgK0mAyMCADY+mHG/4QYPg+EAP08jhF0K/R/J7v1DLEEerpQOhD+pjN4bW6nOpurfxN3ihZuDs5ya/Wo1K73lTjGAawYPqXt+6quX1+E7asCSnXVakYaYsICkPGi82dsxhHhmt8UAzFSDALlef9GTpnVbNerPkCd971VKJ00318M4/ua/Tsmm/23M5n7Iw4k57iifxNZ3TKpdmv8iHDY6r/oH1XDCpo1j4ASLTtpc6ObsMvhrlayZmUwWaaWFFevd7TR+jY8UvWlMTsvezBhgGIanEEtJR7lDNhWOhdE4NB+jylum6hmzHZSWhlKO7J854vUgfbuOxxq07k2bX3G8PJL++fwAKALihbMLNS6kGXRZbpOGBLKleDrjuHH3iBIdXoN0KtF3y/Bgntw2n+yD1EXEbeKN0iBqqpUKPS64luYBCbNLfGQltj2mdqObittmeq3JeUV8yEAQLxHUjj/3hOGWH2HImNpHExOekqlL6qeMVbA7cv0bP7M820re8vqziyMGKuDhK5LRvxsMOvIQuSGU/R2KOanfILLunUj+0V7J+WQ+IZ4ydEVzcmlleCKZSE6v9C0J4LEgw1VrTmuveh8d1knObh2V42pEwCYfISZKec06MggwHA8t3ZCoXT+T0jNuP/DRlM8T9gCRs72Brgrc1OR0V7GNsh3NYbbeY3EWiyTfGU/Ko8Gt/GyMUr4AobwfeFnNQGs5LfI4uX85jo7Henr8yXIbJm0VX2JqqLbaUPG1jV2ajgKOa+Xy/WzYt/35kBCVofd+ujN+RGDbFqzVr3fsRBxfXLISOynoLLQxZdoSGdfMDxCkOWeRnm7IOkh2r/F32EetSBGp1y1yrJe9++PPLX1rRzmCDbhTBrGV2xR9RnlDQGXXHmBCMy+8Z9hJNhigKCMQP12LybGQFQtyWuobYCHH54fFf1ZccI978jA8I7LWG31GZxlNgJm4JK6xSQeyWYQQbRc5ygRXGbgJHX/e6/xUpEFrpalGEsW8pcKt2s5cCkUlM0Uel+018ftAb33wWnA2UgVk2iumyAbx4Y4143VlXy4Rn0IxbgxNSS+ekX1MIwiKOqP5M+tHZ5C9jZ1zqD5lmrE/x8vLHrvbCQnIylATgVE1T1KRYu6hhT++mlxrL/84eogeZzGUMDa0eFNay1D5bHC2+XUG64maBrY4cz3POWFPCf/+9WFye1fnPU0TyyMHErzvGzSNie2DcEe7bfHj7eXEf1sfh5W4ftA/J6d88ZFOduzxgMca/R1CmpHirg+FqhJVMpvowtKVNRAommBXeMqlMFEh8voxoHFy5HjZ3nroRFtrutF6TiR+NP4zQHF9alKyo0EGO4RD9fZTlKf/ng81QHnYi9oKrjpsEejhJEwsijAuZAA7tsaszD981syoBXBYdRyps2l1uUGyiltuvNqaJALJYBINK1gTu58vLYYNlVppoN3DwOGrnjldeCDV8kZ+bKItcSiFwJoQxkR0LjT01LncpV58beRFJ1wXCWHmZXA5kmryxkOmZPYY+adDoE4ncqQH+XwDGYiN06Y6S9ECouKXq+93N2fT8+l27KDAf78tfTc4OBDreuPEckIOWGvWYIZbWXn+QeT8udby+Nf04Fey99lKBPd4IB5HcYXZ52TOYP8IcncvWy/swQ4Vt8kWKbyipmRCbs4F/p3BhpyzOyKuHJ1qNDe2+XAUrkujXgDMK3lytDCy/0om6Mm/6Nnm64pGdX2HBJd9Jjg6pC6BVlBaP9v/GV8xvC9d68nJvW0FsRHG8xxmJ4cZOTudb1cHXxc1RlFJAtA8l8QFGRdXGn+41UWA8jMu4md3dnsVZa3wHPwd6mVTWcaRfYv4LWkoEAxufcl/mgKW9dP3FJ+COOQ2uGn/oabCMsNfceJkPuOqgGerRsN8N3pa/qYJ5vTuxo9R9delgLdSr0Ggx3tfODvduGLJTCFw+awIl4TETaiivOvM2MxZb+Qn+gWe5WQExeRFeDRsOVYGrRbNxMWGQrfAm4hXQnheR/hFxN7PznXGs/5BZFWcKgeRbs32bfKP4KJ4fwo8XuUuA3qwIV1b41820z4wNDUWJjDHBODiXocPpgjabF+qu+yV4KBPlTmWj/WDRVqQVgP/KzQvI1gMD5/BqNnmUCcLNxpvWHb/u0dG4M4GxDk8cqAlTs8bOjOld/Oe1Mb2D2zMLDNUw30lRu5v24JsR4ZoKaE8oNPLhpUlt/NckeqJs1ecpdSgZ1TO54q3FtY+3V0J6bhNud6xSo5S9ffyD0YkzFv/mAqDDmzx7OjGRs9dGMsuYvJLKNX73cHKE+PmA5v099DtKhlEij/sCuo4eBrkv7TamjX77yV5ucjMmg2ufBw3kvqnI514/BqtuWTiojCRjozb8J/5QngPKm+909dfCIf5Za+XK54kZqngjEMymx+lVQJr0tQdbcFzeGYioRgiIj2gYP1rUcTONt2DusBmLndZ9uRStCE2tNhWhsNwCY6XC026S/B37Hrm8C5qCwDoYrmx3PYf/z2efcdrIlTHLONnA0jmfCS7cqWzo18vBvyfAOOvf79H4TFt6vIV9HnC6I4gEQhLuyhuk32RhOPtTe9PUeabg53X6HMa1WCKECykYC1Z9FchH42Hx7DQrwLDffMzc03TyVZ43dKqvC92grPcATn1NrWQBibvq5nQ0ONYNXIUqEl/LpoNHa31NXuxa4Tqjx1Out5P0BcHxTGXNRoHMfeqGqZOObtz9/JTzLlFFeh0N930tu4JSMdcuI4Yxhk5RI+huthsJ7PuX3eOWWwncKDYSw8iKVSkfn135kGf9n/Bkd0UO3gLqOf2+nSpZ60Gfd+Pjy6OckexMEyxRKsh5uCtoebtUbvX6KLn0J221dYT9kol06gYUVlJYzKT9FJCHJoUNEPQ1e/CVT+u8PEKysM9tdnt10sc69kaIyWRfSri1l4s7LiFRKoEZXhKUl2vRs13+0l7+HzDfsKF1Lyvoy8WTdCKsZZ68hFvBpi1LQadYgDdV9HBLeLIZwoG0rlDeXUQTvpbJtM+mrawT+SwgnEphxx5PMGqHgFTKQ7p0ZsErzl5guWKIl4FZ6Eg3F5AR3H9hrak09Kv1U8hXeN+sGNbw6Di4t4nUXpITUVY8mYem34OfIoLM3nUN/hIkMgwViPehTZb8r9UbYozXZ+4VYwhy/PkrR8n6XLStw6M6fSRMRtyiLw2dLU0mzmJdOD0V8JI2vNhszi9BRj130N5eZLphK/Zq5Xv+ByB5oI7w3jmagvOp3wQ+TF0MY+EOFA8wpyv9DlEgOWtIFME57jl1P/wm29GngRpgLNA/HHBJvEZhrMARCVc1cb11yKfhrgEt5Dj1FE4dB3Qi/kN56lRjDU4+UWulBb4+6LfKM4KH4+h2iqlM8iRI54n56bA8zOdg/qb1PO4Br54/AIyLU+IjsIY+lF14jo7OboOLBr7QIoux53W434tKwDkPPzJfRUKq4IEfrsKHJ9QxPpMY0J0Lz9LbXBwLa0prp+VFrgJwRV4BKigqBbGGlim1OYnI+9wF6/RT/QuzicvHvbcuRTNr8pspv8ZjdOz5zL/RvIq+pD5ZMJn8lFchm1w3unhLeVLkQxWHh8Tz/HZr6n8hZhoFN30clJN28iEMrN1BO1zoi4Eubpjx8rKDfmLM/WzstxFwt48FHQw5g2Oetv1kjvegT2QFTjCLE7/rrHMIhpqnACWL1sVDGJnbGK5kufjYi5WSkd5f23ab96KVMlQqLlIfGFvvzsiCO/WTPq8ZUE5OnLB741YY60sVcReo7DLEPxKpjIP5t0KjUjnzPLdo2losnrdseV2PoWxNCA38JkVQ9jDMJZqwQ69EPQweKY18n8cwXYqhlIvTPFSJ5RdE3O1KkLRkSzjdrg1mrpJBhEmui0REiB2MAcAjNOMge4UC4B+jq06QCkdmn5IHUQIiSHz31gQIwm0fGJmfO7JgxgSV60XWy9OcnXn9wS72CK3PeFACy+ertdrg0dGGcANBUZepVnOmfq2lYS6utvETUaXWAntPfqXJ3Zi90jh7u8mRdxVn7zMONdfWBbr9590gZayVz9C8T2Y1/7tB3oepiiuNtc0gEC/CE9yDQ67W1nB6Ixgrn/Lz0KocFU67smcS8bGtPtevHHPrekkj8jYn5bX0EJW+gIyPPkicKwsQx5wUJCZ7vg8DKcz54v9g0aLGuRpKWORznLbWqJqMc5CLIl9ZHqAA1/liOtm+iO/oOJp3szbzKfk4amiFv2A7AofatMuHk359lsi6AVh1aOrwRmeJxWf3yEWDbTGXldnaDVdhXQFdwIByJmXY1uxSGdw6YoUKDqwOj/szJjnvSJNSMNn/dB2FBsPnByo6uCo3N3fp1l85vrItI7XbOzAw3M3BcJ0HtPgq9KCV10llMUNiO/kQobNhHf+WzyJ2CStmHn9E6a6Q9I7n3zwX6MGum4gbC0zqutA0adCz0ubU/WoFVSHACa+Etgr98vRQnAXy2LrBEsrx3pHPjKW+GFBCx70V9OMj1Bt9ioKpxjNDQKMiMqTqMN/EI7Ctc2FjqXBGKNwO2MzthynaK7VXhL56qo67+2A7uduXc+uhL34mlsTN2EBywwPUTYSONcu7hwBrtPl0w1UljwJupM5qHqtqToeYOHjB1iZXUSoTPq26KgWKsxDs0gqey9/B5G6P6eHaBAHCMExroCGgVWdpqISZb6jrTnAICPWfNZ80NEr3V6YY/TBB5Z+iS+LPQ1mDLqOLIlDNf4D+97gWgXvbnvcfQTSGg3QrOy54R8UjB5cB69KhtSkGfTApaQqg5x76/mR7uJRsyb5NOhPwTS8a8LlKzBA7sZ7SFgCmV3AGAjQu8A9DNZ8nqcD9oxHDytk7WRpLFdjs8kXLAGTeN7ddwZFKsHaeldoqljlgjt21WmFRSL28nBbMThfsPV9M/fK3y60X2tR+mAq81bNZYxjSJBsS/bqXTviecfwjWYGb7Jv9Ixc/P33NHzGRNlLd0Y+ewSJ3JCqMmfP3QWbp9FVYYIrVGpsMqB5dH/ID/jDlMpGrI6fzhSbXvImtErmN/ka83/ULV5jimtXVhcBzaoDwd1DoCjg8YGC4cv6HQpKN4n4ogTY/d/J+JFUu1c6D7I/NSHXFw4xDHlRUrrtp6uqZR03C4wlmBlzcy7xg0o+1bDxLQlnpH1Jndy0ob7UbYGP3mqqsMU1L0Pfb/0M3qq9/NvR91c+C4CN2bDKKgcpNgStNiOSk4HGrWEY4Hu5aR9yy0JnCkVvlQm4O3TmSZuZiuezOajT9KV3Tj0MSpmC5y5MV3UfpWa3zhr1lFg21AIMUJf1hiiNd1WMmCzAdmiw+7n9f5wQi3bJVIInKArcL7BB4v7UF73y4OE7fRIfIj/5NQPrBMGdT4NtxTJXES1VSAGeBdV77ZEBD+N7HsDVMDEsPOzrIIEwbFScALOv85u653KajhBiSsrw3ArqaBfibt7uPxpXkjBFcpc/odc7dbHEIkeo8L74yZHgkNmU29UyMjHPp5+hdrVrHDnx2KxnqKUxfsGcmROnTNdwHxG5UFWvqVUmO74zKvQ2cZY/AO3IdzE2BFYhMYc3mbH/mjzSp8eM/FnE8uspMCbgIIEjh146q03C4pICryLjCxWnPpBW7aQBaZRkiDaSCXsEGBJtVthiTwKS91H5KG/TKjpYkzRSgO+XuB+jRrLOJF2gurJFvSH2Wh1SCsjz4efFuv1NvSa2vwBB6Emsx6+bbIU2JjX2TQavcjrBxhqnU88quBTxrRJJHwE6qF2au4SC5WW+knrDSW9SHbBY+eBYKgctx5hKondYoqLSMfnf5hlqrLdKhMr453s8mtSaFO26PaVAGAmjmic90ZDVg9q39SDDxqyaroC69NCQ0rhcCIauA+p103e++SLGvqEIjUUbo9/hZwjw1fnObYHG5V6NTQtqkp0eHAqE1+8zBZ09FsjtqbboC8J3nH+/eyO/LY9S6E/zMnMYTOMmp4RvVnVB0MLLpcTsGnI2AAulddRsjV4ePyUPrBywVrl58kFOP2GnOxUIk66+zpqnPnW0tIfJbmFpg4vypdwvPMLu7XG5ASqa+wypT9CLIHaitM7VAtgrbYtmBvA1pcJOgiRp4wZaf9wDh6KoYzo48/VK6pyTQi9w16dHBzMZIY4RnDRtyCDJts5K5KX4xDx5YkthbMy42KRp8qPv2BsMhipzYGQWwAxP6lrJ8X/xO2rdHR05hXaGxnVK4yu0R0uF8gctEXcd/QlHz9VqSKYnfr7dWC6smBQSPYaKVBdy6Wz2nbeelOXNOrq4GlLYpcQvEnDwzP+5byL08Mljglq0GdP9w6ts2MLhghg3WZJWStxd+dXsstmuVCAmwtGxwG1lAPdmGnBl7pq54SPZaGeFYiUUbP/75+4LkEK3l73tgXvy3V/iPwztZyZk25e3wUVnVDbSRHlDas94pgfkMmUUi1rDK8EEFpUDfk+JxgV2Iha2eTiEBw/1+Uy+poiOguKcE6+6wVmSC6toDEKKkmAF+3UZ+GBMubDajhhGcVsYx/ZdYvHwaaKXEHeQSlnKxGyn3QE3yB1p+xH5LDKvNTg82cFFqVYfMLOIAMnJtZo2jEC2TDyy4q5dLieUuEz21BkuOhQBMjBXMlNr1UkZ9Sj6cfKRx5Bag5IVEpHbQ2lJIFYs9O3wTPbSt5qVtkTtQFxCeeVJN38Bbr1/bIdO/SLdEhT3ns4o7+aqEFnii6i6O0gdq94uooiSNOBd0LXkuM6obNDDLnavP0GsdG6S65V2MEY2DPcV2SEZFRZsxo/bTPouCG5E6V8ppQH16WvKS8a6nIWAw0ed+Iebc+z5ZcB4SyIWsAZZPGgMoKT3NnWEDwHAM9raC3tyIdDDvU3jy90e/oCUA9hCqOl0wfBZnNNuvyV4yZaHD/1if0tSlx8LY/Xzplq5JVjbRxBJoPgKJw1VKfZdft5vouGW7EbPtWcVzX8ceUE6CY03iUd1Fvg42BE7XhyGiNpVCzkvwvb/6iBFggIVmLl/u46zdxtJo4EXPjnDvb+sAySKrqxL/aFDIV0dxRseAr38KY4GIrbGAW3U8G9uOvOFSAx9i/UYi/z/zZ1UXAfBPiyoDerApUXhTszpHjpuiazTRJY5XbERDqQuBLdDWO0EQ5gkl/o1HxpOWRTQpxXR/4Zp7dtTxnOydt9bTFLwt5cmAOi66iIklrnpyEX/+sIla+A0H6nBj8BcvYxNvrDJzIxyg/v6FXmc3GqYEduQmJq2/CHgQeJPp9dwvHcSN11DeQ2TlyMhP6DJwvWONRljKZdv5Ob7XYSahRVfcjKQpHoUxGXhad1zm43zeGXweQgy94nAxRe080B6m6FwpW/V4At7wINU57gXtla/UzAtk0vZAng0yNGJS86qwo0t1bGWvePGZ8kAZ2cjHhggQfFfsn7YkpsdpYNyQGyRfGqHMm2WtW469E18hj49ipRYkqcIl8t/DCY8U1ZcH7TKU+LSHk50lRnP/IQnRsmq6T8JPjdYRL1kBwsE/M2ZqMYbad+pYNFPLPKoIKSEQNeJcLpb2z4/KRzcuZGzaRQ9Z1mzD0j3UDUuO096cniO03xyDhTY5+nkPvcWZA/7yX5ZIs+dCs+/7qDrMDK4HxdsZGlSKhIhucy8ssAU4hfDDPBIBC3qw2ci/ZnlBl+raf/3DnPQPWY1NfwmrZ34iPcydMtxdgXKhY8BAK6JFnXviYSLfYD2SOQpRCLmv9JHbs6PZOJNhm0DClWvCN+JID49PGhkzklbOQuBfijwS9uiomiFcg33iHtWj8jMVmyPHqY4A0etsFQvP3jqQ3ZFJc51DQCwRcevaxX/eu++GTHksCBF8OmCnKnFhLM8ny6i4Sj57jeG6g45shV/FhRrUTuTYF5ssDSEFBQz5rBbELRu6sVO1SpXJfrxt2ReRAS08CXd3p2IaIUTnuaI+PAsUVDUfMn6gQlVcKXIv7+/qCI+NAg+2vo+/4kZiSXazQXITtOesQkm/XJoFDWhhrGMljPeZa3Z1XrHjCdXbwAiFeJ2J+xQPhUa6aqVMbVAms5Pkjh8JS8LdqOIsRfPpVihNsO0SVopqfYsDZoOH4LyAwwGZ+g9Ww08/7oOVmQxQTU3dmTrw3BieZ+c0ahCAOs5IKkYxdr3mPPVPVrpOOlWawU+vSm0Hwqep7XDtnXbd1yClLi7Am3m5NPgSAePJdpMJO5MF+oxA4dyXu7XEhzzRkQ+uX4kOPZPctIYnEmqrlyRFTowbrKh3q4iAMWAwLo0VcBeOR4EebI4Tpj15E8wb809nNqOE3fF3besY3oFAGXzn7gcSKoOvCDohsVy/ZIXBpQuhj0omwtctI9rK7Nm+RilNKWzagkRm5WGPKF/+4yKqHYg8b+5xFHKCgiHU63HH5auziE6HcWtiGly6UKUhJvXNz1wd7B3uopwva3NKxZZRYixVqkyvQWTQLbVOcKMWJi2zwqY1Lv3r0P07FNBficLh9dpgdbZ7aqLRGdzWgEeg6j7UysnydG1fmxwvjPNvq0cGSExL6hQECXirbWd12BIBaX2i0sFXyRI4X/1Nqy7o2S78prCQ4FD5ZsUwE3862zA0ZrtEYZ8eMTOErcg+NtjeOBJQhBweauqB1+6lpoH6eTMDblHGhfAy8Q82FrFyZ3B8pLPFaccfpP9fRvrzzYIOqQA7tyZXYUA2Vqy3lMFIz2VWCTkhyTBk1vR+LpE6mY2z73/sMtkYaXo1UhkaGnPqHso6KDevmGgIejZHGi5A1OfEsKpG7VCPyv39zopZxhvKcv7EXi8lWYWRmVuoO53BOCp/rDK/tETuP9A3aknHpWDhIsqbtsVwPAQAukz8mLqgiWLCb5WHSb+sK8Aw9XRf02WhfdcZKUwfkWAtfu48b/M741aXjEd5qyNGCMfNtaItaTcZZQReWDyeQFKV7j/cgqCA10jKVHpL1Omb+/SJEzp9dj6b+Xq0Lc0bcc+iSKfhtwKWXwR+NyqhD6fZ5Bx1WgfyY2uCWRpcJIVId62M147DhLbKBsvQHRKJibj4LSBmVcBiophAT7na/TpYrO43oVeOAUDA1ssKUtCbAj3NH69HcRzlZjjHa/nDB+ZxFn9FNNJIFh9YmnzUy9Ngs71ILXx2w01Ywm19Esz1Cehebpj9Eu2XFlYa9A9J1MvmzoFhaLrO7FDQqoJQzm+6Gd+a5miw2FhKF3alz6sYgsQu/jLcKLXx+ty3gapVqTdKcuACgGsn3PLbgz8+ZEjBlcFCnS9PTBeHdvIPxTRaH8aTQuSJk/EUvf7utzd8uTCJ1q4nXuQxvSBrKntQbb4xdTX90aat5ILJOnxHwizr+0MQrZZy0ISswgm4VhRBKzrrUpNZVixC2iEvVsRkEXi3i8pPIwSKNxMSqNlAhN7Os0vpo/dsEs2GfI+3Kew+lmLmfWD1VLtL+Wyu7NAA5lmfGHh8lJPbiE5Qg4smuKqCL8New8YG/In+UxAt8WF3ZazmNQjR2ksyZ1cmOeULhqyf6cvfYGCMR8MtJSanGW5LjX+FxTbnPlOy9qBJxEqZiZUVGzT/BZQpIXyEXFawZtUaz9vGLqJ8ps0XNL0Y6yJyDcNmsOOMEmBhkJpvRUTImsvgzd3TU7fxwRr6IR1+obc+VnZmrOnMSWgAZ2Tfp9ny7cCgY3W0Al68o3mtp0RbI/41cVS8F9rFlRzZwd751EaYU7IO+Ca2bew+tGu88Y4chpXgOCq9WAw2wp5D6PxoFP7ovfAVNhUAw09wgvZ9w4C8KQ6m2TjLl6qC9Y6a/e98xbY8eap/GsGwOj29KVPfoENFY1v3t0ivxU3akGRIsFTd3t1wJg7DHIgBvQzQ846cm+DlrBw4PBIumraf8eXuROZEiZzBx3tEiwfrVccY7A66Zi9ccP07M8LENZOWWYRN+Ey8yHs0Don6RyX3C8+0iXXUZ8k9H9zeq8DO4BTJOt63TwFV/g8ZzlfnZ2edztcvE5Tq/EaJ2zOu3xZE+FfQoTB1+Ll7ojcaVVhNfmMZ7ky/1Qz1r4m0n807ddkA7NLPO6Mgqrh+sE1f1SyuL1xRc0bsNs9shHCS2vSBuwBp7+LVdz//e+cB8KgIk2C7W+2bEZnFjFHvHiMBUNE/NqlUeH+plbrLY0Xsy9t1Dr2sX1Cw4eMoS3XFn3ZNcpPAEky+Bh3EJ4XbWBXzX6txg9fQIosXyhmlbupwO8dMqz7cnwS/Kz1G3z5LN2XtJUzd3NhDlCRKVXNCWllflecL9vXiqNQxQYIjm5d2vFoAUhMXLWhMH0aiBRN0UpV0FN5yQ83chhzSnnN+eI0OO3w9bUGS7j+btsORsc4/zUgbMNvYnzodITUrTXcZ7i3/UGmJ4PRTf0C6EzNafsVDXgrOYTACPb9n5ZUtoSB7tQiwCBv0kueqWXpDXWExe8Wv2BPLvHXsaqXa1hhdfCjE7zkw/ySBTapFMWQ85lnZ5TmldBT19CBfnH1Pd+3w1QbkrjeL0hiOAEzjDf6IbA2bKsK6r/PZk6yIEmVZJLsAwATAEmsRMp2k+vThcLpXvUt2Pj8Kvg7XpiBKZaBvXLaGmgqyqpxCKvCBL+tSwgJn9/d99hJiHjh2ZjnRqe+VwwVRcpQVTSFStxqQDS+Up52v8hfahfSDug8UWRAHvxaZM297/VOxf/ayDarpOywbIlKaYvsYlF2SaUw4/yDDyb2f+LSwEyBCkxy5UOR+v3kFWc0tqQvGSa1bfDrtnYFS0Aus6o8+e7JIdVl1JWRZASoLXMMgt/kWpltuQhR+t/xBS4uYb6g3o4xeaaEdtcxqVfBGIcn3HS7GV4k6yxp3UCo/cimKyMCZoOAHuqUrvgAPA75D+aWq0t597JgrtCesjVY31XHob83DTvRdbrHNAjGoSN2wSvirEXCL+N4jQ0gQkcSk/AJybZf6ilPOQ6EHfDnYiOAczWsXT0adgTF8cXU6yPysMmKATxRG5vxYlKae4rWbx5V5IRG0o3RkqIBu0Xo1aL5ZnazbeOYx6G2D4w7HoPEgZx13gdt01x4V5cJBVRe7cL+5ayAjggo7SjUSRhkvgSXtICU1c2Qtvy0Dwbqq+aeM6VcZ5umkm4vCCsMtaA7eRMJDVcyK/fJByboRfx/iyTgxkwY4OeJlHzieFGvUdN0lCluUgFd/2kYNcfQAlnRh36+b3QfZ3Z18OlO2nmTAcFyjlUwLEfKZfrmEnlB8RFksXn0iBakjL1wv79iDOZV4aQbLTCWqlqu7/bs3gUZc+lX9xxEsG/gq4BNhMINyK/+uMISDx5+21B4gWuNastxZw5/m6KEs2L0I0f60GgJrINeHSPV9r4Kmt3afeOTBQwtOVXBAx42LnH7+/gf3c0/WfDxbrxtmz3bgwEMBkyQoz8+Zwq/F0iq2vzg2IQF9YQU+sm485Zzkx/rvXgrggf2NJsJNcIGaaOkKW6nUBAH9zdBWN9YCAyP+r0cHxwFCWgbTPyFPI5Sb9W9iqK920je6vR+93RcLWD4j3Ah9ziUOTFDSzXaY0A7H3BfAeo3Znx7bfpkA4EvKgJFFuC2fX3PzgOipU9gwff7npboVn+3HHZ6EGX2C3IIdmixvjOWmu3N5edArx3WwRBgTcyWsSyu1T4RPbFObQvrxQ5ek9cdYLNrT4e/O3UuQXS+vHDEGr/bo9gfOlNuY1r2gklMK2ZuKloY3AUhMZMQ362VEerfFGAMnrnpjwxF7dRxA9jEnaaALUV9vwdFP8YYahs9VpVHaYoTpkYms2c2+uMK9H/rghNQGE8A4ihtSb3M9qz8xpjLCz94/2BK/+BG/9/Wyqip/a2cBDPWOyuVTkohAtKWOjTelkV1zXrJ9HsMlRkLcr/cklh74phUFXhiJXL7K5oqm9r+wz5X1vrXlnFVIcEY7npzetCMOCKVCKh2rsRB7vypPapAG+MdaE79qw/BwiuCek2n3aKq0PRa+vCFQWQXPjitld8CEUljhYBeYVzlbDYCAve7RJf5lqhnTMi2ia6OJFvXyVuWpSeGucygfCrUlBx1XQb4R8dPhFgkKgoifo6XQIioSa6JaYzDPEOvN+rg+6SICCpis3bvmPKFUhGLoNJHPUCu/bk3qm9mk+jnQDBR4/VRL0oLoVpQhmAG8a2bVt4j8VvTNtgse6m2mUo8g0+SUhog0Ykswy2/q1F1yi5am/zeWWlBAGXcuNTMKZ7JQDPIV/y7aEg5SH5tutXHcTsuLSXLKAMIMJiIafAsYmdc0/mY1GbUUSYNpdeMrXlBEe7pTeR+ZG/AigMYh1WDTT90PLuWfn1uIX+kPpb7Sh+n2iaGupOLry3Oa6iL8cvn3Nn7aZ25G+g1bScTfTNKWQtZ37LCAcngUHu5lJvHV7LpS+I8726bUCqzIktbvdaPRtd8i3mAy9i7hdh8Hj34+EYkMg5K4Gzb4J4EejcweriTOdir6bzjbXfHrGY437qOrkjQkinTMJUvuPZEU7z54qsmD4dBSptBnvkIXVWaolOs4cS9A5hE5HZ7NAGnjpISBv9rV0NhiEyvZmCj2qkm3VhILUGTajYBphSErJgm/4L+aAcktQNMsTbJlRY53syBcWD8AULw1bO1Njr3ub6+pGxBQOLyIhWRrUbRif4WmIICHtI2eMy7FdF+lnuFGx/8wFd3O606yhz0JB9lC4mq+6evnN765YiZ1DTBCFuYRiRTmIV7KaqlCnRl/DPDbxIIsOEMNr+/I4/iVZkIBENsX+1pCFMEgx/xelJ3U9TWzQR4s/pTbSuVPYpEuycBcJ0g04x6xc8hSePOOQXwkgBppdv3l9FeHvugjXHUpLvOE9z8DGM+B2PZIl9QEy/8DZBeiBpbr3F4EELBkLWiOVa8oCZJzaF9NB0lIpgL2TckRgGRmLWr1qigak7PmZWNbEiRmNzRa3kyyiamJ7fDj90aGt81B41bX0UMC8EkV4AKKcEVfSbC2pwqJsi/sXAFYRHISC19fNGf9ZZ2AcizJb6e/2svSTAkJnMD3mLi+5DhNUZzWwMKuilPdcVU2d7ljo+bFyahev77ltcBVdokezmxQkgB1TD1TZ1efjHNmGwjmeE9pU484DZyqLGVgALz4soemyMC2nisnYIoJMj7dMCoh09bRKnK5vAx3x8/DKFHrcGFeLEAcpmu1Qyvp1uWra/j14gri0RcnTlS0tn52IrKUPUS7hBPt+rL893W+HM0MzJhm3sJxl6NVzrSpn+8U9DU/ZBihIY5k99zL3zjSeR1jCt2V8xgd8saIa7FzwIFJkSlsSyMtpb8WX6aMuRcJf/d/5hwC3zsv2flRJF0iwtmGo/PjG5wNPYeK0lRV05681kVi95kqc0u36NQadC0rUtf7ZToScKfI4BOVx3TIb3nxyNd3l5MCEfO/Arct6YKpvy7yoilFcOsib58D/j+pzoTHD8Dqwd+GVTmS1L/nz7wdM8bWT8XiiiLtl7zh1CpbUZCxwDGSIIP+gcrKB2eGTFykBe5Nuz+32SZdoGi7hcAIeJZY8TC7Hc+OVjh9h5vkj/zULmRY4r1YBWiITDB/P7BP4UnakrMOkYJSJUK81aBt7e3srRXbBaUlxhkTMFGNqNN04ilaGdjOpqCbS1iu2nTiBOsKMXmt9XbrgI+p7Fs7ZASJaA+MIOgaZdRVU83NA4yZzkTAZXTW+9z2O8H66lMQIgbNh6vR/9lqg4lYZnpq9q5tq+Unmqe/ZRlw3UGm4G2nKFuMibJwY5Nj5WcG9dRuwq9d/rXuwD2LXTGYx83jGXSeJIN6iYOCUfj8S7QUM5udG77oESeZhOd8xrLHBnkQPyZaeg4HJcupDVDRJ6GTyOmee0J2SBCgtKNXRMLJzYC+yaNuD6ZAmfAD9vAvbCTHOEdBriLnM8g6tjjF/V3ZqNVlvDQsG879D87oWWHfezXFV6Fc9CITSg1z0m05dUyk2GidmOT1w8g8U7lyBirdKOWpcfFwaaOxtmfQZFeo5JboOcu8T35y/IGrhWX57qAKNZ130B2s3BKCtt24j6kDM8hUsALj6ggCkMfANqFe1VTFcwJOdz9cmiu1mqinx0KM4eeoskufxcoh/dUdviJDqLtBbxdGRPpFnbG4Lg8FojFvQ4cS37enF6hD0ot5BY5DSC1asU56fVbwrLz3EeqxJ7pIHP492u5C8QCCW0ogVv4EQ/73PL6E1fO0LISEBZYb1jNW94wdXFHi77CIB71H7yyLTfwBDHajnsIQ3lXaovn9hfn96h1yP6LRS+Bhn24d0LqXTpQZZUlKuaJWVw6vZB0d6lnosPTHrkiO6P04Uz9r+J9wVw2e9OfM+/xnNjJt5MTajbd1CD9/Yp9kaSTMQb2R42imzc7I7KshVliD0/zRmkNC6RrbB3W2bkLKizfcI0CgkUg5nhhdrBJ0P4CPjtYE4gmro0wAs6gnxI3M7J5mIpGjgiHALlNzWrxiINSWvCQUNudCEvCFSPBSoMZZYqfvo37rjcBreNBNbobLAikqQ/mxjVwum6v55Qr7VwY0Ac8W3Ggaj7J1+i821o3l7ZCIx9x60xajSr+CX4iKDAKz/96/Rpc6qQaXWKYC8thbyp/A15W9iFNTc9dixa2Rbdg4JCH403CoS5Fm1kf98GOnEpUCGqS+9J1d+x8ko8ML6UfAW3cPvXFxak7Hm0km6chKaJmtDgo4ovR4OUqye3yIK4F/9Ooh5LJGjYsfRsnZNcmHph9ZIA3V4YaoxR4Cs0pWiwoinuStCcLI7ufn6JJ8u3b2qVrTOHVGd2YP8Ql9uK8XLUeVIRHbGU41kYhBfKlB2PUGTOFhLEnj6EyT6AuIllRoVbOCN7Vmd8g1MO+jW9wSI4Us5xTbnOkGhxrf97gtP8G/FqbXgCIcC0vsG5sJDIJ5p9Mn1yaB86pmkRCUJg/bP4VmJ8+KJh5VSkWCS0FLhcYcc+GnpXMVHk2njHH4/y2mB33BsBD1SSOFcmvAwnC2FBFxK1sOuJbnITo1LIsNWHLb9ZmbeOHsRpzlbM4ju85LaFXyRfMo7jTV+X7JZplZLJogB/Y5+QXIb3f+2d0o3qkkYK1SE3XFJrE6Qa1o5OWOjot/xTg8VqoB4sPWunsDMHoIclXyfCOI4IfCOWwbcmsyZxPE4x9b/wI+WCdGIonY816aZlRrpCcXTqJCrYkbIUT0cyuktNkmT4T7PkZsocVGoFhX8i1GGgxf56q0FGemuCVDNdvE98aHKyXSmutqvhesvl6bq1NlpjmMa/b5VNciGcYmvWumVfd4x/XYBBlUtynaO+EfPsnIBOQFmSFi59zG7bEmeeMV4vi+k92Nj8Lt3RCs1y1ZKtJJt3OBAQkdY/ouSese8+JVImhUGZ1V68ODTIC4jjBuZCmk5Jyywbz+1e6g20GegFOL6YnQMqwP0br/F02+tquRxWPa/YIFAPn5woshHgP7nWx/P9m4/A3lN1zhZhrSswFajIHmMZxcax9bl/HmKX+O+PqZ7G2cIZ7DZ35XJ6Vl6LOW+SCpHKK5hbDsxpDMbEi6ACxNN46RaIKRtNkjAJv3o6sPuotjkqX7QxqrNnKun4OA3DUtjkCXAcrTBSF5kyH0S3RhCwu7BpD/Y7LgMxZwgbAOlgBjc9i/MTEV4FfSIyzI+ArCNzac+QvwmZRy5sljMK2dvnJp9s95dPKRQt5/AETNq5GWfTiXTqrlgqdAx9XX1OQTxb7QR31RbPKX3zzUCz3oDGPoPnaC9M9QjuDvVAKI8v8Znu7kqfOVc4gJfCEC77gBJlLRQko1IDwQqkHz9dpV2x13+KccYy7ZqqteQUxbv0DiU3Iz7FIkgwuOrioIOpWpA3gEieym3EFq4e0Sb/SSlbwfDvrKCXLaaraQULLIHUu8+ZOhNqnb9x2+6SxKmnM3YrTCyL7d/MpxX4MNgGmelXJyBMRhQi53T9jpLDHcFJKYBurKmWLLwcV5975Xh1UNIbL+TknwvRsRuK1yo3YMVPf+AZUpAuTVV0SvUIkrJ0pV7YBbKa9SNXHTbbIsn6qWM+gp/78quCihy9/uvtojNiGtL4bAin8HVEXyXkJkQ45ICZxKnBLwYgXb9ZqGAUOpJPt6Ol5WqW2GqM8qlgWdZMuMu9JkWUPccoEQoGa1enwta6vbIjKDgdXvljh08OlKDWNjF68i2v+95uOfNQy1nzoTTRop1s3gHUAZ+KnTkazPC2qstZyKLkxvzWsAG/x6rvrA3O2h34gCWLdXyOA+ursCRs3vjniNmi1TiOislamNdWmgTwtA32UhUrijQbQpnAGE++n+WW9vnw9I0/oxbpYoaw1bayb4rixSOtUW2qutFvdX4EOcr/xHSznyLXaec8jsl7wbd0Cf8juG6BDpTfI+ZVNJ2QuD96W41jpq7OXzOga2FtOPRP5VWNyRRf4E60+EOoSKmMClEfHEuZceHQOILGK0XzZKerAZpJsSQzbVHSI+3DGVwZja+tlZjShvfsCmcSSUFoG9S7aNadpl+nNAHKVrSqPgfdQD93ATkKhwx2Jd7jyaBB0vNy3LXpYgSLLwml2jc21vArdYf1sQCwkzTW7XyG2Mtq6eYYCf4E37MdSY2sOv13H9NyiPi6NTxkKSoxpllNw5fuz/MahYH/ntc9cZNVQK6U1TgjwjQqJ4Xvs0kytmAGMWXUf7rV3GBmxjt8fI2Zbl9RE8jdvihqG9d7jQo5pp+Oh2oofMsGAUnsVrc9B+rlVz3GkFTWR+4MiBVWYi2jpFIuobw1MEb6ScjRKKbhc1gu23wWqwUgGeJFQ0j5xpyq2910ZbieyXHagmAYNZrNegLSB0/ZElFFefNKNpJ7UodC07LAUNt8ig5z/yIn2BAyXHve0xkaZVxRHDlrMZJQ6yyWCMvPPf5eMIFaU+x6wq9JcX03gyLHPvpzBYLqg5KIyIaWhP4lyqNp0tK3iyRP4ZZxnrbyaQdpuJl5L99rRnkWWF17N7hfF7ZgjNU0Ixi0K1oNLyfNGroJYsOTpjh/psUJXuUDMfoc0NcrWAL503k9/bxsw62OzL2fzs4Y9t64k8w+SwpvQwzbclDZwQesUzo8YSVYiJdrbpe4F/oKuqRa7qxG7Iriz2P3hCAmKYH+h+rQVJqJsm7Md88PPQrc/hsP1iconF3vi9mWxPu8+a9v+f8/MzgOgx6Nc4z7OPY2cR3pGymNOj5j06a+4r+crcjB5ytSTnzphSk4mkVX9Vewbvr97Tnmuy4TJ3o/5d9hrin0ezTtQjfr7h1keE5hAsYWLDqekxzhsib5klj+f8KuHSqhNyof+97hs3YuozslQjzCDy3avjjQ++MEzX8iFD9Eh60nbjaVL1k1q5Sk8yx4WSk8jqJTSN3awYBFnOhywCj7Cw1IMsPIIQtuggG+Ut8uOvVOHEis2gqybirCJ7/d5GwDZvYBo69shjnNVKSxziFb1toxo64MKyj5Mv3ILGiWd5hmWI++PJoHfiJvf6L/jTx4hNLjisG2TDtrAqRpXnExkpvmBGSS4Vb/66Hmu9cN421UW6iobR2D0tnARVSlruoi+a5v0o35ETltXkehqjPUaIVLK5q74jV+QoRvjisP9z8SyW3QsStcOQSMgA7W/imm0Fo7bXkjkzgya/GG6N2YJfblb+lfz5LpxMAIaZt0eLgvui8Dludnsdzlrkpkn8z3gUIWia7rEYMHRoFR4j91Q95AijC8r22kbWn5s3mYiO9LmtaESfcoX8isS6IgbfH/b3yAbWqc1s/ES1OdfF9KGExTBFfCKgHZBXKs/UEmQZcu4vf1o52wqbAtkkirTYqHZrddPLZDWbvzrkYnEdwngKAjdENsUvl2p/5wfbLDCVn1Twa1yJDw3WoqrsxGkkrZM/SxKmqQoqkpLXbzkLsn3OGhcdeMtA83LZD0t4WbLrbkAfE7GTqqv7HXhR6RfIud0nNLuiGnaZxSkB1q8WKiFWMABKfZLHm7awmnGDBALjnOfV2pOcH7PxxK3myHFvQz/rHW4lM+HzONKzysixGQUxboQcivDWwQTLDN79tpVvR8GdfGbtQ+2D+QqkuhAi8mtgEiNL08ExUL1lube9RLeNW/48+tA7cjAXUslZ7UImd53P25w8Qe2MGXuE0/Bk6BvJILXmiIE+uItbcJ7mzs6wJETDnrWKmsHpVYPl9JEBamff5GGWsU3cMNWFekooEDjqO32qE0GjB7knmP2/jhHEsk1YYwa7JerwZxPxxLIIvHll2g2rMO3VJnGJjQ1Vv0QlrUT6xcEzIQjuunlUa9ipPFLjOUhD2M3sR5SGOjBe8SqkTH9mfsrMCmDnA/dvK+nBi1x/U0YHNwBDdpgzUYQRn2G4HbIdQ5YYyUGJNNLd67Nf/LGeHyE5JOTpZ6VyfUX5R+xhPD0cL4CMgJmdmU3Q0ZW5zlnemEghAQPvrIgsGRYe0ICrCaDsz97CyRyOLlDM0rTnWvfI91YeZQV8DbJVfQJcsopP6JNLRd9Te6/lzkrtjFpVKgE2hqyk/ltvOlG9UOTt1eugnSq5ZYRGn19OO8L953TRe+IpuZ5p/W6hs5k3/pMKfwOdexJxd+hNFDr4+UiVzuN40BTscY/muKPcz5QMuFA6MGOGXS25fCbMZCOGvAVBzlYWB4G+Koh0pjvKuzzesCxuFg1aI89Ue26HsSMbxAG0qSqfAvYZDbV+U4P+CTK6jOLC+YNO8DeySxqMR9+n3TlDG1xmHUaFNQCAdzeTa3qOKlxLZxpnwdjdqe3VRjQmQoQJiRGKbsORBlZx0OEIGxfFLHHhqAmcmJt2h0Y2sARddV+xcdOkF8XL9bx4nBHYc2OZE4eD3DJT7At80cMf6669rbK2sYoEXy9CE27z/gPTU8xaq8vEvMTn6lsuYNZSJSA25v2C44pY0sPOz0kpF2E7ldLsFCwIjt8dRY64ZlFNYMDiEq5yxYAScttNgztpNPKjMTMeViBJ/JeB24xNf6l7CyzStMOfDU3tkCASr5ESTCTvb7ICNIjvv26KD7MVeuOwvJ4EBfi47GNwXpkKWrrODGsmlEmIiT1yNsxswb88adICea/Gy1FVvKU6Po9KElKaAOW/hqQfDiMEAaK6caXr2yhPhfeyU1V6Ga9X+nDuCK8bADJxRaw6+Dpd7sBGRBHIzSQopjqJ2akN+lJYnT2J2mciHX1LpXvwp3PxIFtWEqCtCPfd72qkpGhWkZ3hGajw4SdR6c4xqkN7rRSfEM8v1AP4C1cB8C3bQO8HmtlsFFv3OWfqNLq4fdPZMb6YAAkIEojMTkjLxbN2FhCn+q3HQPCzFSsNCBP2EdV4LmeOrVM2s7vEu9QephWP2ixvs/OMW8OqbgHP/3fteEknmzTiKREgYoYUOfYnXPEIDl+7fjomiCE8s3ypTPdiH4m3ciFX+Tlril8HP52u7JE/hTcQhMaRwfYTpoZMfumU7BTKNQc9r92BFhhO6856QXC+Nfxv/40FodGQTCKidBhZvZ9RuH/zwP6Du9C7Hp4YgYXeNkGPxgOTyG7rVuKNgH3mJ0AGeyVLiGqG5H8tLRUV9hAry54vKg08q+Z3ZVHBVrS6lcTCLKigQz06yQmVW+MdiWOAKMDB4heW5LRT+HP6jjdrfZv72wdv4+uNqBMUvuFXaR2whvczX1hAzzRdjrkYsDSVdOPShWQh/SWYH/oR6oczPsGuqJI+Zp1O56uMVkX+0i7isYHhLDPCgqcVqv6OnZAlfiDiJ5ssSFFXQUqdA1O0xpxCzxaj8Pz18P6Xvhge72kTKfKRWtCfuPZ94hEcRIv8C6b4BZgkW/9TaWtFVvs3RTQG61fZs+x+jcoywmZIjj9jDRRPr80x+EgWMx8VeHzF5ZLH6iw6a68AlUSDRRBUGPz//VYYEaulEUFA2TruiiDs9G+N9J3OduG6kXIjVVeG5lHgF7CjBizUO1qbDnscVWJN+iDbt3fyihSdYq50HXLLhxwc8P9JxrE0JAJSec9J/Vt6eUx4lK6OW4nS4C6uaE9vvn3+S2Q3hZa/uzuFyswPIKZpaG23Y0VDFetHfNeqNFxZ5jRGq225PxyNXIcDb07vm9nEpwRR4bVjXyBTzI5uC2Gyzu4jYWAOG5T6nITjDVed/1iC1BuzTmE8j6orXapoJ++dFyB9v66a74g3j1Qnm+aGfN9x3QbvSAP1GLcsDUdUT7LRdmfZ3MuJhjtw7oNhiDB3Tfbr5PClWqW3MWphhGHK3lm9F8eGwnd5SA/ax3SsnIxc3NkP6GuobuEXSlelt7zGH8w91bp7VrXCTK/GHbw9JBi6mm1cjKwjWLyn3bjnMd/YHl2WQM+oSy8u2PtFoxtpZOUvTvy7DG4FvPTt1/km/qEdscW57TvU7Jj8ew1k0IiN2jmGXX1Zpo907kq400uYbAIF12akMJQzujGtdAvR1OU9De3qOPeKVYp68CR2TlLKtOM7QL1uVArgyTJ0ecrbcdrN8sG0IihUcRKGM+7BQn1XNUkCBCwqkunEWfXnAQ5yDfAoLjTsTVsHddnLfZUZkjf1OeSlOaJnR935WE6Vvj+QkUcneUz0KWigbZmNkcUDP+oe6IcyianYFx1Bq2Vdzimi3vW93ExJqHpX2BInxDbLvwXgFOi83sgZO3K/2TKjaR93AKl7gYjSc7rBcl3AdDnDYFmWJPsMZksVY8SVkZvdQvZqZw/N68rKQmz0uDYlc9zgTze3tZm4EE9SzPwtH8D/ZyKyvFR2xTA6Q+gXapxso22Mr2+fIQ5FgEDyqDR/uGnzd4l3DTTaRCXDzak35vCuIeHuOYuNqF+u7otM2XbDItKUGlb5cNQH3pNBnvrRvBVg4sK1wSrekRDXtq9/LLOorwDh1zf3A8774UW563njdCNgsGwePFiNgvJ8eRk6NG+R3KpbcsICDj7RFbX19SsTZ3Ie6DKNkHrRZQ9/9bBn1kEtGbulPmnzR6XtbSAiKQ3xi3Lc3EqGDaTQaKbaQKmLDFSMCOr7fVNMQnU6PmtFGHrAn1GE+vYlwJMRyGKkN+XrGYBfmvn8FCbAZ+bnoTJeT1jN/c4urklzADybi3GLYDM/hd0cP4Sq6MNoxtuW6lmcrI5YWgNvhcjFpfp/++vK+v/XDyat9RZ/UApZdZXiqu0878mI46uyiyGqreiSvagTkjQJ5xkSl31aRg2iuYvwEHPLvKfMgOseSxmUWo7BPPr1eisv1p9w9+GOX/eUlNtTYwJCSuPo19BdZClfFi2+78v5NrFc9M3cDF4F+MBiTcw9E8nXWLyx6LhBfDfQBr/Acj38SyxbiaGBJRBuvpPv1/rmZCmPlVYmUGsukci8tn/0/EGRlyfUki3oBqsxMZVYyCel4BgIXgZYdoVIAlhpLUJHuS9xRVRMNSw8+1V5VkTdWnG7+vY9vbLMkvK33YZmUMyIj9NltksZVrmJ1dZ2RtRTqMSfZi6lNGihZglA9uKIePjYQmNZ1Z5LZl0N5PBCYlF9U3yKGRgzVijAnAnrvuWmyJMLp09mc1OoPMSUut07nE7KTAoQjnLbL+TALlRlJAqIynUMA5cbhuGZL0B18M2xEJHamN1/cHAcHfimcHnr/YZUVRifv8uvipX7IyDaSntPrUXA9xzbk4Ls2RXgq/v+RrX+bdeQtA/zCFy4yBCSnZr24lEWHHCBX+m1hW/Sp4r9r9xzxfUDynvaNzzMRAPMsvpbLwW2RE+Gx73JwA9n3I9wPaHjaV3o+FU3W0lBzmGPCMlg6qQyZSOH+l3CoXaaHBa5DYiRIeXqcT20Wd8SFE+BPELPPHT/GaSmviryYX36vMQr1TPIYnCW5kEuUpkRJK1ArTC5vtdJbKuLwuWjBVQ/VXn97DQx60GXjpEGm5ilch7Amx2im7jKJRz+TmzoNIR3628xJIQ0qg4QImXhMH3Bs8dkmTWwuuN5ZfBKUk+4lalxDE3xiX8gdbTt7fmL78QjbJpssEP3ZmwOndolac3WOkP70G884oW8D3Lf9gHsu2Nd1Cs7LLDUHCoedew5VGE01LwEjWFZ9Fjx5qNqup03NMCkBCmOGZ9icqnoju5lbWq7oLuWqtPje/AJkh9JoXQD0OweRdgzFiUHWbmQQRr1KJ8lDD1cODn2kSVU4XHuosbvwB+/2pK1OGSY2TQfV+0ktLGCNbdvuaF+aVTr81hMqe11TSqqJrx7WXiLmNEw2S0fnBnHop9qlk75g8pyolng69cWh+2iuaXQ3gs/wsg2oYIlzM4+6x1eimE+93AmlHVkPQtcXkwcGFqHrUeTfEPU50a/hy32NBtEvZXQlwF7d+sMMiX75MQKfh1XgpQ0FjN5nqUKgKMPkm1EY1dgOOwV5y/6LhkhXeovrdnpq9MUq00XdFxDuXwK9fJ3h3vvGWlk8vPO9Zy1Cgi2gvW7ibblpKkCVcmtGklYAfb/K2v5HVH/vSWuGI9lmwrzbQQun0pmw/z8ICgAcIQrYOL49YeQXpLiP9nnI6h4Qo0ejhy/u1RXxczbKwd5ecGkatNd3x4vrZUNebwjuYtjoTSFyAzxtlO16c6hbWCdtJm9D58YJxHV/oR120TF/+RYOkeI6DhjqcpFpyjkjZuuiCZfANOZlBoiapPhcR8FF/fmnWCgFmyEsjt0H6uRa7Q23M2RLLb+pkO9lNFwLvuRmELdm1dyOT7HT7H3XiJ8Z3ef1LZryprI90plUSwUfWHy/qc2x9GWmnbuHAJXSwhMD6Kv7aOGUdMdzfwxZyy/uEp1+3GRH9xvddpyMM6mIaKTlCtMPZsr5+JJ3Sv1caaBHY5Qk5Qxl1A2ktiFN/7ysglsF57ga65dP40jyBD/ojPmDduZNHGNTjqiWwEeKQMlifQq7o7pRhq/6ionW79X+xKE3r1rhmjgwwGLTCXnDWrq7ovI828jpBPUs3MlzxE6dazG5sJ+ju8xzppr3YFGJEjZ6OvMsyO6YkaGgAeX0Ie2RsmkwfiCYrKTzJlWe71OFEj/HCDCgTAfGorrxFLjZfutDc3iMK9jzHzVWZQv6er0UGIMuzUOgzwa5QEQbs3KoHWM3tTF8wPYjzhqtFDBob2wr8weHMIcPUXL3SX17WcUIHuSdAiWWf/SzytJCJVLzUdTOONph9f0GQI2+osbg9aATBmupDk7FOURR9XF02cN4YeGzmKluiragjlN0ZDv10Y+YzhMzfWdgWN6SQAESTehInaVoVNtyXTfp67NFD+uuTU0U2ZIpHmWRguQV4TdcoFk993WMMWUWo2xUvbPA6dck2/sbl+YwARZknuVANcAQiwjz48658OVsVpvqM/5e+bzCO1BYTgkE2hCvCayYKhrsrxtNJCOn6l9Bkbn5rv6dv2BmFDLuM+ZgtM5WjXRRS/W/6bCbxo4bsJ9458FSPTl0er10lbWardLHxA1Pc2xpbLCymY9/gJVqO2Beb4DCHw4Fr7k6/yZ7fJTK5+06sWjtiM341gvA6b806Pm/5Ncm2fX8kCfSZcHkemCvIcLbw78DecILiD/ABUNDoHUCLX9Wom/Rpe6+O3AMA0w79yaLepnkgZ9SRfHeVMkJnLRyZD1ldXR/BiZwzpU9JAoZBt9KaNasZOq+yCginuvFaNhmXBMZc7GhA0DVwDfJNUAHpee0F7CwBRl5PPmGg6cU+H8dY4Qo59Aq1EI9x+LfqmQPLz8TNZMsPVL9ncmSJRC+IaWuvPgVIVa5yVR5pxz89awjEaU6kW9KAcfGHhm7IsoORD0ndc4uxIj/ep5NXBZUGZRSQY4u7vSFbrbuqx6+Ac6UpHLYrGch2UK1ABEfN/DHan9AFG+6mm8ziN0B8iJCw5stI2hd+bYTb1HfDLqINPfnZDItgODk3iBTkwjFu+PpMXKdw3/sHPAmnzo18eJDWhe7aQOoLX+8gvJgEjDj5mn0TRBN75UPuPz0DVV3mOd9+K9q2iso29ajNOOq5XtW5VKHGklbSGV2gASxOU77qsLUVqBMGGi8I26Je2bcUS8620+VIip599ZFqtb/CYN1cakMtoMPoJv9gVGVYDEdFNBi0BqZAzU7JpINdEWCQLWjI3Do2s8jYn1Zj8ehai4sgFONHFuzZRnjDxRpgAGHvUs94Xj22xakVcqk/cCkZy7WtQZj2BjZ74Rm2nTWELzvAaSYMJXggQp+5GcRpJPeUzrqYV1UnXp7+IUUh9m5ywq0gcB9ElpEJOGNjiP5Wm8394R5Qd9Bm21BPPJxm3QGhgFKyIpJqGUzuAcFYWWCAFjE3lauxva7csTI7wpEWomUnmYkA08AlItkvQHSIUsYVhhdh0jUOk5yN+OSnsZsZJAdPU4Qpl9P8XnfvUwiR6aKop+R4SwgkzAbpp307Mn2ENf11mVyUuzo2LQmipac/eVe7QVctN2zIDNyZwJa88hIXbh8fi+fh6sTUYq9CILg70j6d8ycUuEtRV2IvxWHeUq3c0Vccmix9TEC7etquhxg2Xkdc7dfiDmjrcrjiZmmcKJdLm9600z5AvQSMV6plTPAghDP/4Z7kwKPyRnEyAC0P+Pdno+Cpm0rOe5hZiIChidvq1RPjNj15SGHyQNnMT7fFvQnSEPu9ljJzYsIEfULW3A1Q1l12XqSmdNSKQ9L+Q3C8gMemT245++Qqdjpu5OR/BdO1WQbDdm+1rQZTEP9/r7bKLUS9+RHMJoAADGrXI2AVtLE+/itZegCuVL/Zgdnmj3onHy8m0SUjEAaIDrBF28KQGx50+sJe4FGgYABGGyMKyM8gmRmxrst8ZV1lnG85PkXZGGEq0+UwIXrjp1n/3KmsgLZUaTt1rqvOK5t+eaQ3dFrY5nCMjmL+C0wchiCOG51c5u8uVKs50q0URVPN0LR5n22n6Y7ss1jDXQzb8ZSfrzNhFN+KeQxKwsZOrRyrJDRUNyDtLWE7M1KqKo+CtP5ST1bpJjNLUGUTP1aE6Ff2FbbJKqQuDLByG6oAbpXQUMtDpoGraIcBpBAxLp24xNPHg/EWZvJslpR/NBfrZs2vzuuiLZ9/xCWgGcZA5m4spstVr0yPhMIpzcAP+7XGVbwdClmIj5bUU+Vo9a8hs1lhK66UcS4uxAWZvDykQtWil+4o0FSF1M/ZM6Tz4b7ii4a+akVoinYdDHYgJb/Nm6d8i4BGEDv2VUf7T6wsV3YsSGZOzISecYE3U0EtIPo0I5DVCSGdYknCAkgrswWo1Ke8glSTKWljG8VHzzXfLb0PAsdNR/zqF+MSDljw2L0TS3K7dV+h1YSDY2BDvjf2zWnx0iFBfGaFePNn3zIrxo54g9xTG8ZP8f0M3Pm98OrtxlZosZtVwRrp+0/XksyPU41jfT+7pEEMfmDVhHMY2/QUgVo4TCCUJStZGg53acMrF6fT+BIPtmpVDgpS+0jwniCcd+P10vKYdc/1EIN5XIkBhR25mWwx5ceUvYVLBAHPNA+bOhOpL+dwVb5GOuWQRGe6cJZSdqyH4fS8dB688iNfsCpzyB+0ZDS2H2D4IVxopB3j9vusPQzw1c3w/luvS+cku4fc0qjxxXPL2yVwW6XM/wDNFWWLA0umklX8KXGwecHes9VWNpLAyhIW8/6uhiaqz0iZM1FXuNx/GAc0A7t6RaymD4GqBIFegAzTe9IMVs2rdmoeHDSLlleV16yu2Mh5nrJHBdf0MVGmBhvm1OmpeU7g3tawPmPTY/pU9LSRxAkrJDqQJ+msymUR3GXm3u1lYYbcsgXX0hyfnbnaGYHHSfBo+7PdS64U/2cfAuT+a3JemG86/LT23w2AXtP/mQ3ISjJXyl8kEfHEHJHnglt0eqxsC3Shs50XIVhSw2rJ0XALzMSIMA/US2OYQMNLl1QeE97QLH9B16s/DQVg5r3R3Gfa3HwkVUz7bgZtstpIDqJ3zz0pUkKXuGeCIh283WtJf+lhNJk3272gknxj1jrP0qY/F/fNIkpLp/oWyqXBgNtColgJUAZNOXDGAwL58CrlIEMdRXz1ql4ZDPBsZ3NT0vaKJWQWYYmIOlLN6OyfrorJF4WAnCIpkIi6rAk71BgDF07hylgpum9gK+5PbhxYkO0TIyFxVKxLQ6OWMATD88Zrvwf87eee1U1RT7cDiHoDe5RaIiaaJRmKnZ222Ab84DGWpV20lFtDh0jhCdwYAsX1V+k1hfTG2C3XfuaHtv7uH6g5mkcstO9CdQyx9FGfQAfZbW6kkobv8EN1h3090Ru1Ral9C434PCsy5s+P+29pInRX46lyDenC+LnJVRsiuvBx6R4MRKPQNKsQHRB53TXVLPc0/hXa+HDrSM3n/wNZvE5Ra+h1at6P4qUS73KQhLvS8Gm533iDvYi4XcKQyKYgX/jkk7biCG6bYHnGjmluZhKLBzLhBqvfWsjgPJk7c96dX+L1eRV06CUWJ04/o6JC0QZzJqnj/vdI2o6gVXCSVRwgUda02EPzD5mx9iUg0XdlIk4fBBFdioVFhi9tzD2uyd3bFGmjCYq5EjYcx1CmtAWVTIvApq+yWMwMYen4CK4ZHEp9OcQyhkZbhwAf4fG4oynbBKYJ/IUNyw6BIAX8iYlVlN7mO8KoLo8GIthH5WpEpn7ptz+dzJWRRgrXHD9E7z1VdL/kNjWH9ofv/jlU/vdiHw0xCsEIOluFYzhi9VZEksMIxOzdlfOov+x1EhzAmQ+lJQGShTRnqOgg108oq/IbONmWHgjA7MDmPXWSkdWEzblIpaR83JKWRVbnRKiK7cAbSeR8BTpYz+b1hSXOQTuq1SqZRhN4+3yZG4VP3vzEc2FDVE+9WmMQVIIHLp+tuzp3/CuiZflIvf7CKmP4zRtWrKtiVg6+omwxB5S/uoSHPXfSs/O0zJTKbYfU7LDWLMJpIIxDxyqRbsDQi2mjVsoMgO25pyEpLNDNRqjssNRHzo4y7o66ZO0Sr6oCsrEiniVYnQjhhKjcwWLY+dg9BUrpDwiedJDOx5CSHezxe4XlpV5Go//8fwa5tnyzkGoiJJxzDdank/7ryDpN3t59F5JdrzcldF6sirpnET4xe0UJnoZgJD9SpkmuH2c9sUZJndCcd2v/cb6uAB0zU3oY3YwZXAFLXW6MzKUHpFw9mWia8HQ8bipjp9+/JtWJhvmJtPoMtis8q/6dIvIw2iuV2f0o2f+gEUpcazK+vxzEMvu3o8sNnPEslC1RbWORTBTZY6N/9p06vG8jLun/uLtG/PmDwLldpxjpp2Bo2QXK786uG29+wzIxfcmtC/SN4KqG/HrByB1BEK/ixDB2de2wf/kSUF4jGpxKDhcKkwe+2Gn4llX33oy4ooZ8f4Nrx2FCzHfEWrWD7Gzbruxl0p8G7pYSXdQus7Txf2odgZYuuPws74tNwfwZo2H8TBAfgFccEpuKG296vZ5G4ROLshBWDmXs7C8/gMUDK7KORx+JJrv7WXnaXDxoMjNudP8e2QgW18vbFp7Y9yhNoX8WYHvcXaGxOu5RU5MPy9M5UANpDU4bNtYDsxce08MhgoJ0P1iOF4LOhZIEXe1ngOB8O5yGqiNaj7OwCFvxwHheSVejZYwjxwyWlTUU+uTcF4g3t838jyATD/HIHgHbwbSW4FR8PotuKyvE8lIGHJMTqLNz7PvjvYWA5XuzmTVWlUraZSGLXeQtt7nuAUBnKHHiqsp7GGArQQ2fXmwJfMgCtzGt7F5HbDYht8IMymy8znVZMnWPT7KJuP+DBstSvxC7G/NucBtbmZZh0ybp0rK+OC5OgLxXmHBFmTsn9vVkxsvlPjVx8I1JPe0JpC9GEaMTF08j2PM9ofD9Fo+AmNtXnYIFwOVlCq14YL3ckjVZQSMg+FpNFZmcfrFI4xk88kdniv40kOzwvOCDwCvCL4tRfY6MJ7gTwZcvQxFH/elgitwy4ifkuh/mQ+bb+rN+zZvnutbkvPITWRjbVXqKk6EZ9iOACJG7QFh/fJepiABatyAjKJRB6NScHQ+Y6tmfNZ1oAbNv8nmsLKskA6R5ZpJI+bNbvJLRHEMLX5lSu/GytuaOOy2piG4MU0GUcLZXrB8D6799gOWlGAr8uIRJIlq9ftoymnDIe6b0GC8yFRel3zHDfCr92AGHpewTffcoY/De0JTOJNv+k/v5GjMLnKIQgb/UDIVcE0lRiCdBDFEZasOQGW0W6PvxDWvLPIITXjRV/j/V9g4SQ/gM8fx8+GM89Ls+jPDE8jmUhOIw6ZsZcgwd/YcUqqQeH/FYe5LCgIqDA0ahMRzPQ7GY0FyjbtMkcdwKUClgHW0PMyUnLA2287P0tFmiJp2Gb48myhFvxgfj8EjUaO7T57MJGUTL9RjrTzN8YYpQ2G8urUTvU5TOTceyBFLkZXD1B+c7FgjSidvYeA3KsQ//Z6Zno9bze+pX18+PDKLNlpLV/owuuEfqCvMAGJzXSo24vXVHhGy4uKgAPdasw/t6jKL1lXLe3F7B5Lo2LPgOMi9JVL/Lk1HpEXCBJMXVT9GqvU7bvvussZ0n++LEBUzaMDPt2kPAhTWUPshIgnMY1fG8RlTyuN3RL3swaAeYNiDwd8wYo2tmYIMYLdNHUVTlDQUGuHNU5rvwFYeq4b7fFHvJguk9m+qvXOJrdwyG/gSgyV4j5EnlLHg8l03ZAbqnpkehnPWLphBTqg7eSngn/sgD1RLwrViPJpsG3qjyF/1G0Z2vz+I0KXPsOK2wyWRS4i3o4zISwN8PQ9OIpS8V/vObJzdGsM85NuWz0EqpJIGXVJGgqZi5bhQvwfmJ3gmYQV6dUIPRWzkjBFRGR7qJEL8UkCPxZV17NbYEAkQW1NcUBQXu2FmeuYimO40XeVYUFrU7rLCSVLAmFIVOMUOXoxdnJZP0L50wpPLiROVYMxjK+pxtYYz3pzLv40u43E5+ucRq0shUzJTKk+PvkyPyPX3bRWGW+2sc0sSjyl9LJ1ZqccRAwHMv5p6Ro++t6Wd9Y/Jm3i1RuIdfGrVAJy1Q1yH41hM2FpNQibyEI9SDYFCC+lmGpONceNBxAsAKO6KkOwOo0Pek3FsEv3sMX+j2HDkj+5r1VpOkUS4BBMQ5zleDGBHV2+lQ9JcAGEAhkdA2104NPcbd5qZt1aV0wzCuQUN53KbpLcAyXciqLtsAmpBs9SUxp+vHkrmbiqskVpveHjvm+LhjOop8+FFSYrEyWD60HRMBjUZ1/6GLLCHnKTrZ9csGmugTZxiaCDstYTU7l9Mc+DNUcTtmigoOfAMJscDh4g/VflOQIRLuB9yY3mPxoyieiJfSUf/rbrm5lff8oaSds/tFTxzFZHtLWlN/WsrZ46Vnrs58jtQ/dq5HbNFQLI4D0c3RYB/BnkwmFduO10GATkdMEqSeO+uwLi2n2cDKofk6zGuvL+fxime9wcQUYT4WjozSunbIre7E2mokHuKOW7cgj6vJAW0SqPlH/DXtZalej/MCaN/2Twqip+8kYwuERqm8o0EL6GrP0pVcOmhcZWpJGP7FicaT6NtFrSMXqYmCXq/DcI/BlY8ZjOz1beNfQ3vyKl8Gs1OeckS0XCQh+2sfLiGUAYwIOVv2NFmvbfR+oBjeCag4pZBYOD/Zidf6Qo+3y2Udx+s0R27gdOkjPDAPv1lI7eTBbnZWGvGZVMKQdt6+/eGbjmWs0m4DfS3Upuo6idKJGeC5WTrmskrbgYnoBOra+9nWLm5WtALLrXVNtV+rjJFmmb9L2lexGBjNWuWdtzofDfPvI2ChG3z9Kk1XrVTJEa4uCtbEZSB6TSphNdEIbFdJag1icgk6/YqCBSDh0lXqbuDC9X7bel/0awGdriYPdmU9BLTFPKE1r9xRFavNHjLrX9mNdr22VebFoc0gXWLmmuK0ScwuB7pkToCuF4CmCpgZOUpDL0m37TndnvmEI+yFj5Ho+SB69oBcxJlvfPwIx2VceDe8SKnysp0bGNs+yu8BWu+8ziWnVQYt/34stcTU3ENDVfVVFebBPJo4djlL+wf3cYZHGkkGhF6RlS9Un/9o6xzIRDgW2iOHb6gFd+DiMpd8b2c8/iyC6ngbGX/mDlKkdUOYFccGw0xbHKYRkB/9H8tzoNdSEd5VDCXa9A/zJh/dWmrRCfcG71eklKAJLqzy82kj8YT0Nn2m8e3vCzUpmKutiCZ7//GFA0odHZYoh9ui9MRnNzx6GO1bqAkZQCoDGjVSQjXAOVCwpj6la5KbtQlgWrM8u/heBaumiNW8BZ6IH5tJmdZnYleG3XbZeJL6Tv2rm392vy94T9c8B/XPeqllw09O1r0RXVUAq4C82H+ziI0yUf45K07aM2I1SQp2+zJhvZ6gxWnmtn/L5DeZG9MdFTav/oT2nluL9ayGb3PVa8sbfT+VPp+d+rcpLivT+rlfVk0zNSIYsIjI6ZpFTrHJ/RostqgbBvHmNein2eC+1ws1+66sh+i0p3RA5BadHslHjnT3G7G1L3NBZNMf81RgyfZAccKMvqe3BpLDYDojAGUnpQOmtt9XHaZ0z8kIYnlJ0VYa9YEmS7tXHVhob9WL6+A0Nyy/OszrUj0wV2zPSl3WV6w8TwHIU9tY5FogEiTWkXjG0z5qt0ZNZBCmNCpnd3tEL/kGmdQPN+HRTxCjm6xukLlbpoq78bkfeK7ECdhMrg+ZlbVxzaSGczgLAMU7mFpYWdV0tH005wQB5Fzkn209CSdKM4lwYSzxwTZ8S2Ney/s8FmkN9vZbpo7/nj7mrh3IV69DSsW5pZRQ34mxvVbftQ46WTYFBFz1Yf2TmJd5HDFN5RXYz7xyV4G3qzkK4WEucUPUriPKy/Wdi9sSbrMmvoPKJpSbSWLO39nq60bu+zG4fMBRJchnPJ5reQKjLW5E0h745sG/cupE7G21EKAg3gRJN0t/eYNit9ntp1nZSPD1Ii5hP3FWMQj9Ct2V3CKrehdSpGp5vTQ+FlYoPU4n4ofbb+X3eWEQwhrGAusnA2ERfUSjYNEgLNFDv0sGGsJB4diWa7scFjiVmEffWGYWWwNMfBQjv+AKkJDh35epH4Gy71ziKwCU1/8zshUFbneWvjVpvdYQwWf2Gq+05ymL3hAF827dWtTdgZh7ULAcbtjV8GIlqwwAVPBr5JBHLsPZWE1ruplQMWiFFkNMDTIT/wlFlCFqD85B/aL3ADNftAR9em2r6cN1Yw6VkDcOEP4XPULcbZjcBCS4UMLlAVCiNxOdfarCySJbRWBjKxd6Znv8GblE32qyMi4R5JiEXdGo22r3T752ybNVT+Q5qre1g+uRVw83VUalWGyM2PWqH4gDlGnZv0hzWyfvMA8R2xKSxo/kiSdM5xcjTOtqe7stnEayv+cw/FW9yB8j+q/S6h2DtRFUfKxGXhC0ybo/amfvEusUrEefvsFgNS1GzfinDyX4pg6ScTizG8LBqXyTsZ5EBFV8lbUJe2jaHvDtjwOEkXduEETJ7+hZt+NMCLefVOvbBEpkvyZ7qF1qTyDXVsuognu5l2h+gPYLy1As+A2bKWm0IZlWv9TQ2SKcg5ATczkUAGhBjgog+hkQ642YsaZ3fD7sahlSYXD3yK/Xk/QEjQDUJO8eT/GYbZgyQmIym7VK5XhFUK+yGsXF5pevbvex3c2SRRPCgNiWlFeIYRkrY9Zs5PVDk4bVs5e7smdpq/Bl0JScPqn2PA8tOxrU4JjOkV4WCvV8tMcRfsudoJ4RRWX/CcnuhtOVt6rbEG6+l/hpfb+AsrtkwWDOqDzTuHVa/R98orMkOwIEcFK9EuH1F4bfHLLruuwDtZPElk6LWryTO3SeSctThZ/yG650cSAlSaeqMCeqr94cWRATS8p3noehJxUFKmmLjUg6nwI5tqlBqfaKRISUC5ytwnk7TU5oRdExmqct8ZtvPDoa/QRCk57tLcAVv61fXDn3tuvoPM5W7jhlK/mKHtEpT0QGFwr/8jWFRhLWWLveiZxwzn6cVUQ3EVIuduIe4jteMChwjsICnYPwPNtDQUFjOP2iGV8Pb6vzoJaHNzeF01coIIiFNq7jhf3UnQYztSRXhWAZV83bay0ldTgwGo+u9lcRJIqpkonATpNCPjrkNDDDPoUw+4BnN3K/Jf1ol1KLbI1ieBf2qotX8eDoqNX5eoRLUG3vNLItXtqaqu/R3vvffgPwv2wHbKYB06Ap/Li0KwTWTESRGEtghxESsDKUlcYCShCI8JbwqEeYzwb0y/4HgPGcRjhiuoC4quKDMdzdGwn4Vw0n+vz8AJmMw6Bs0Cj4RLXTw2H1Eb2L5LSbeUmJxtBpkDqYML+kTzQIuBakvEP8dxMh/j4gVA02itaHFSM2yqgpvYVHttHa9bO0xUD/+7/pqDotG/ibZEkQWvXnWqETlIakBZOpo4SAnGdosFxdqlerrkQ08avvgfwvTisgf0TCN0ZgjaCLYWykls3o3qW0CpWcGX1sNTUXYE1F442CfovBxbQVpZonkmsI3SHhYhBb9NQ9HmTmQAVUqcp2a8UzJZ+Odd9IDs5Z8qadxSUZ+nbh7HQ1eDrFgzdjwPp7VaJRvY9Dmm7G0QA2aRCTH5rOLfFE7QzthUiKfv2VFTFRzuwf/Qvs2MF5enVcmg0poYIeOUJ8JKVR6rNtRTa4nNqkzx+WseSBLR8re8DI4OcTSL1bCrww05rK2EPyGIJJC6y/Zq3SMLyw82R24U/U2lWfvRlGhCqGDSQiUCEhHxDx3tD1Z3zeTmnn8nmSXGWIi81wEP5tgpW95H0+3nFYJMuQbGejGMjSI+HJxQ3VnBJchb7ma0m+zOjIqwbHEVK5Y8fkGx+yuFYvJM5Nyq1xmsNb87JvaEJN4sbBz20soaU+U2RVFAf2JUNILUajCNaFf/9s9iVA/mVp7/ORoJv1vnTTRuiMYD3ilPzdJQzVKq8Biewys0xRq9hN1153x1CV5XZY8KiIcvMEpN6hNBJmE9sDUPqq9jrTiacCct+hOrsIFIIEVL7VG+w8vWKqYRUKnbqZXtaCOJ6hViBD9mc6wHKAWfKZVUfcJTA80cF+QaL8ARF76tr1+MP/9MGxK1EscQEuF8IC8RhtJM7yumL1h7dK9g2HJ0zDZ++Bu5S8TONX0FShcR5ANgVs6+6lpFwLefrkoQ5UiA9JtkcqstLUlS/UJbB2wzbJrCQKBj9zbY0vbmd0sqAsDlEbRwtGtODd+V6tAqP69d+Il4r1UlJDG142tl2DU/O+r5l9XnzNYmeD/UtEjZJ5NHshqF4lgQXwHoPoCdf8hGZsR1X7/PccqK3PDHzxmZ5EiSgT24a4zkkJ/PRyisp4IeXIwWlvEAhXsa/L6pb/flociryX8S9DZxQiyKj2aUNEJDqknAAZaNqy9JDktySF7KnIuh78xrrgqdhTZMTU9n3PbxN/6mvQc9gIL00bkDudj4EcyNqyTmbyxZJqDtXt61VyiHcqWoneALLltDFBD8jhfNwPQEeM7csSQxkBeuhvh3wKXwIwtXti8lSJvQ1UJiFD5fL2UYzjGtVF3TQ7SV6x6t9sgDvmtp4sqbNov6BIxL30z0KeU9vDigod54S3EdPKHOvprReTVER2o6cG4i5xZXu1WRz/AE6NV81rRBKp0hwfysXdMY+oscyql+YvEo5XvWjaJ+fjGloL6IK+IEwLqtYl21Y5c+sBFinirOpgBHEevMsBKPjKsltQnojIidvPW7/ynyxxfrIaTRJzq7b4icpUwFVTHHst5G0L8o//a/tY2DpTwOEytlKrWJDD+NKAw/mce0NIVu+TpFKLn4i4ycGzU9RTw4Gv+jLpzWh7VekzT1JYrANbj1hy7M9ArQgn67NgthX2oYK6RbZ84vT8lf6/Di3Ihwc62p0d+Ldf4RpqeBoFfwOg3LOQ/njGkdmMgJk6gv17Md4FyOHK7H+pgG41neQWT1EBm7S2A6X0u1GJmWMa/zXlug5qqb4xU6QZsyqHg9erWi9KHG4tPyc/tVGY/KDOTcM+/nZ1KG9rhAZ8thC5V/W1cNYaLluOz5EpEe62smYoXSm4dVSlKpjTD6uliTEGuvauqs67PdE4bOOUC4hV1DjGvs5i4x0KlpgA4toR+LeYYartaFEr2cJVeJvjgAOCfmfBO4j6xKR677GZrDHfTVZWYc+j8M0czfuKOo4YK3tbCkdJiwdtqAaZWv3n/k/q7SBShfLgLy+af6/+m1mtpfx9z00SwBpcfMKLJ3K4Gk98281sCkf4PYfq8by4eyNNLX4S6vqWoI/fePTUNE2TEQnmOZfDL9MRAi1CL+fIS2278aEd/iLMuBMCQLQP5rjt99DfrJ3mFyppfOHWWglp7EEW+RbNhRM4q1kMT7947S2NfCD8VFqhXaeaZH4EFPY1K1xJju8LxtnLEHa2F90PB0ejmtQFT+QReyvC1zX9ca9BizNlY+vK9WlHFmAG0NwghkjIvJWgLl0zTrkVUcgQi1/vq4d3+mfCC4RMZUfXytTYPl3Emj+te7Z2IDzoRkJEamg7d1LV5LyuEXpGrHtwjc26L5a2+5yHii+pgg0OSrDC3lDq6taS5KzLP25No+ma7LF6F/ZUXNEd4Loct09C1xvWXSjGFyJUly29gNy4jiU4ZgA5JXR3GGMBcc6jmrDW057PIodxkigo0wh1IIjpABCbcWIGv8EmpuU0Gb7tPSBLAT1J6jDkDBfVHUTfPRZBE+lDnxiu0+kX+5VCE7NyGyfhU7F7cbrM0Qsp8CkO4IG6UKk9WmpfewLJ7izuuQ46NAMIe51dluCLrHGULepn5Kt85Rcrhxx0uY9Bgi7BF1F/Aje2vsn+DHxcz4PifNpN3Anhre8U+NB6/XHHh4wtsihP3v4y4EKhpeUI9G5kVljxkUqo70nWCb8Dk/nzjIXfgwRzBp0+xBsveM8WaGiEcXmNu2CkfApwVevGt+mCUTDPXzy5OkJyUGIKU/UJ1kPbeXDBewyQXdVVPKonkOpXe0TBNi1lPnoAm1w13NA25rn/gjQP9GdxfV5Efhx4E1TEXNikPIEcNn9CYQOeeR3m3mYsinVRxA4WX79U1/zuL+i2jlJcfLATyc69JL3r5y7aCORrq5HB+2E79Mkg/uUK2V/Zo04w9YYKYpKOxlIxz/E4J7uLr1NLBT2vndTPnc9zwKRfpmTz6uaYwfaOeQGusU5o6mOhkbep1rIh5+5r0Xopv2byB5wsaw/+kvQ+o5w5pzivQGff60eKT90fm5lOjrM4JJjnifcoKBQ+xFxzt8fBnBM2N1G6aACdyhabkpbTITmTjj+FSgsDZ/wY84mRhTbpRbENT/sDaXmN/s78O/iTJ2Uhlqc1KvsZfizRK2dJ/fN88zh1QFvc/2lU2MoxJzzvO5psHW54qGMOo76UMczD/+wxMxc6hL3rt6Ch3QcMmwP4LfzXaCtwq9Imnusxn/kB6WloJLbTiEmXTEfWCLIKVoWlWjFpunknUt3YPPhSSefha2ic9X+a/p+uvgW18Eygxow/zsZudkKZnqVn7JmA0icZMJIYGwEtXx+UGJ7dK2PMOUlyWCeInzaUBNHdbOIlfJUYWxsnD9eI5ktw+AHiNQ2S9QWJOl/zuW1BswICbD0LNEn64ChHf6SJbaR2BGzu1UY2TjOLVm2hcJHy2UEwQYo8HQoCDB+ouujEQY5TR0lMF++Za0yMUFPoR8w972mUrY0C4G4UXtkxUSQlzVXmj1v6MPjdcXfeGPiusn+cfj1lBshxJNga0nw85nId3DFjHeKi10cy+TrI+a+NiMyW1TEMI60/7P7uF1h5abW2D2fwiz+ja9LFVGJwmpS0s4V349n/duymsvJdOUlmlDx5QmzZ6RISdVdTaqIjZ8RVrMKYJU7TzgVPeDSIYlkowQjkN/hr4lEMDfvP9c6yqBp2lHvEMLH+UO47Wq7RxhQRXZDwFhbNs5f7K704v11BpK/XcWVm3SP8Jij4Rd4FNnjhD3oZAMp7RSKX7EIS46oqdpY/m2kLutN3vW3vL8NmaWm5aiYOKKSwsKes4rQBQ/Ss62tG5Cm0UmLr+zad6SRPxISMWBV4KWj1bLXTFXqpWEqnoum8/qwK1YQmNZ8h4t44dKX2w7gIT87XvLMbUZX36wLnlkLx/JES3Nz80fFe9aGhWb/KgzLGtFLwJisxK4ZC6csIe8CkzCwQLWFhSb2vOw2KQZJW24B3rg7R2Rd3my+r6MubR25DrRznka57RMmRaNJQoj4Oh0JHOHbVfC/wMWEpFUMswgvQCALwvdr5x3fz+AKRjsAMVU8yR8aGIJPoSlFTF+7Nms0R4L5/JhSOLF43WM1OdVL1tXJvGbVfU8f/v4is1TJ0oxXmfEAqlNFel/KNRUoIClkdRmObnV91R/zNJyYKRkKyL9CSlDrN0qyIa1vMrftTXnDXx68uuTJvVB6dybHxzfd8A+ZfuwMcTT/1d6FuL+i64nJHRfIbbKnskSLGIvz05g5YHAfV/VzRuruPtSyrXdSt+Lm6FPZ0dy5yw+gvJCMRHAsphUQpdM655lnNEjnLm/4SwE2wkz/ff165oAsrSL6ga5e6V0xgHY/XPrsHuWqtkkItJIBLcwJYwQvbruOAIqNuK+x0GGB0vRNNkJmYrzUpQpr5oKHv14H2EEoQgiD2FGi5QVv6qeNt0vTRVL3HLG/ih0BttPUPU3E7UVJdKWxVbOxu/EY72zzkqHIPvPtSTs0GeKMT798ZHu0ksoEDLwtyvorD5JcsgiDPwLGAJOhqX7L9ubvH2raVefCpyeGe00GFRRz3+aFPCFEl5aLaxukzdPZZeVW9wPD/lrAbKK4Ky/vWw8JNVrUtGfK4xIuwfsm8TMY6ftLcw6zJ9uW4yUHv9cRc77WpIf6uMKQKW3zDmFZiGbr6+Z0YitIGt5SmoORdvkPnYu0oyzRd9I/rfulhJGZGTcfMmXTnHHnNB4epSRPr57vDQ0/K4Sx2tOQ9WyHNG/8GZlaj0m5KtccsUbfysL6BF4rSOt92hIV5ClJ0eXJ7NfDX8kC+hnppFXEYgr6L4jrQJXSTCUkOVso09ONfTTygI2NbQiIMGc/vdUcNck5dxCjHcFdu81MCHQifYMWnufrg6+Y1nB8AmteHRQu9mAW+ukP+iJVGdzFiOwTcdtLHvJQMwJi9SWi7PnZHDPjir/YNK5+EYbwTG9tdlmU6W6nTMPHNfL4m41DUAnMrSiPs58Yuc/n+SdoPnj6UbjLfUHmKbu5xSKUyGesNvE4EXupeJyRFur3/Ud0YU7g9WKvyWcjADYt/CAsZXZOK+goDHOsoqeuZcd63dJABQpp1EZ1wJtAgvk3vT9tM8gmunIYIsFndZiUoNS3wzcT7xwZH+QF0c34PjLK9FPS8WJpbY7BROCB9rH6feytKVGnMpGQsYH48oFaAnmF0dsxxS8YBCCbYjtWHNxHlMpC2ANJCer76caWoMxA8023zLQ06Fmi3A9doSLiwqWUBAjAkJDCVJsoLIWqvBMO/QCYBMWJbc47euu+B5DkAiOO3iJW2hdatV8H70qAVg9INr1YEJ+WeyAAH/jjkRhFbcb/YnGfZvW3HUf3yVSh6gee6A3zCwaRXnKgXYrGEO6qq/ti3y7+E6s9GifyaZ/AFv/m64xembZaceItZ9jz8uYP4/1oeEYbTvvTSKNM9UzGOEdtxc0T071BC2rNQQkgQEYYnd77mmChYfp4nUK7WC2zXHYbgVP7BOXMG+el9tBKs+1Jnqg+UvP1erfPpRCwsXibEpIB84fMj3U+eyCcN6MxJOxbgPihxl4sPwKIKQwVQzrFFFyGgl7sdiy63Y85OzHr55bGOxS8BG83FyOwMvX5gBSCU6AyaTXhIN/ag0HedjZp1X6GfkvoLYLX7BGCPzK0Ce6lrMnIaVdKZOyjOd01W6lg7HQT1HCWcj0ivXSAZ9j6oo3pNa2PCAGeC5/nK1/EJFfN19WIZFlY+tSWC/MUMplyqUYrFLLRNIfb/7uR555TdrV9mB9IoLvpLjqg0+OeAtpPqdQVXk1GJx/7fEOvry2KWfnXKKlfz42ZVAhsYvrlg7Sd0RkAcnB9I73DXI7J1FY2WOAdjBVfffR/DtUgBXMsnt26MNlq+uQoYmElh+AFMCbYvkVKC7ZPz1PDkxNvuUt1oGSRC3xgL2cPzGfusXwMrn5Hx2qR0L3EUgm7UJkr+bSKcEmZqU4Dbef4GUX1COQWSAfiyYzWojAdVk9dlSxEhqwcM2v4KUQbdIhCV872f4Tfs0qXkb8eNq8Af0tWBxbvc/SXrp/e4iOb9Zs+LWmSh7IHOSs+Yo//6XX6sN4hRCI4CfStsyxs+CCOhpHl6BhXyTS04F6HrWu4g89NdeSdA0DCE9YIW5NqyLXRu3cUgiZ06E1DcrRYgX/rzqP3Dg82W+O04mb6wG6MGzETgbwnibhiy8fC/6MBaofmF2+4LtyS5CEktbE/fhThG5ltiCv2Bri1DPUR9zCsFyrLJTErvcNOhphXfcktDR0co26iBMIEq30KXOrPlWBsLbzCCizSV4bEdIj8cyVR+6WnKDzm8nsCB2aQ4ZBPXZLNyh/oqzryv45ZCAjPUmNWzgV8ysZMsokL39jUyC/G6ljTHMgoIt3aWX9MxaWWJ3F/JXHpx8ARWxHdH49JxhanOOcTG7BnYzfjk1DKvsvcfVjAv0bTK3gJ8syODE0G0b+zjTzdBDs/0eLsFekJ+zaapN/uINjHhpFKeblvXEZe9V8RHkpBHJjXA53OIvmKinpfAUUoD/1r1pQrstjCUvW0PIs0RGVogxPuyY+jZp4xuYxdg6pTSPjbQK2CFqALUhz7+E2LiiLa9+OnMe8dVgZ6nH8Aw9HUxmwR1qyamcPGu7Ov0emq8D2lu9OFBLCbz2ZCQLMZdLQRl/EZG8GqAboXakntUk4lo87+HSeZKExsWw6aWAYZhHBFY6VKxZmG436TaNryuSIWn6AYuy00jzSezCBq6PUAAfn7hPAWzB3VowN9VBnSn6cIDxVVZLwcBPFtUcJdH72jVftSytG2vo2Wil7TWs/B/fVCiCKvgWZFsAAA3iMupqGRLNgm5tPB3c/LSyooFRzisZBDi7v6AcwSnXsVpzD6IMsR4w16z83ILJizT8T6vk4gGUHuNrjKFZ/Gy+LRXoOLenvcZR5+ePs0HWd+A3McRhWTzLq4d3bJ3RU0xXPRtlq2XU6228xpZKdM8Ujdp1yADIDDQx61weN3Q4pn3nzM0Iqga8UKlAaMRsmZUpnSBORYLSao0OU5O4mYLPOHrlNlHza/NLb0u2Gi530ndajEa7Ztu1QQM1n/i8pxDDl8tqYq0u+vdeAqlbg7ly/y07fHUk22/N3Bm8rssvHhKCT6Cd+1s1lKZJmokKj/RZC6pA+YUi0wxEBKsbS3RwGki+N9BrS9BfiVONDDclE3GvuKXOT3Y9XYwgGNiRGeGq1V3OBoiTJpfanv1/j7s26bryYNxtmFynEYjWBlDP0B/yxjmYaGIPGOEH5JpyqWcQBF7752aCGC7p7ZvtYe3/YtsK2Q+ef7nh64TzacaqRyWHuzEF1LNj++AS64/Q+0dz4TFV4bYlMy6q+Ao8MGf/IcAR8XZgr1ZWoBcnInfqqkCxS62bM0UVx8E5mYSiFb95FVCxOKchTiG0DwM6Cwah7HaMgv9ZQcEjh0clfPZbvlF0dYqkgStgLHuHcihy1bOUKl8gtx+dOaqnKsj9w1vlPd8j8a34OBr3dm1NpqHug64kbpNuEKrtEFvTI/HkAc2UN/Fn9CVhD2pmh/RtUujZzx0N5Vi4lbM6BGKLLTXvoHozDQGh3O+IA2Rxvu6VMwMWU7RyyVDDRjnaxmfI6cxX8sW85yvMjCaHbM1ctxaf6I1B3Rf5hR0T2hOS3jInfooRQFyOnXsdjtOilesk7NmbetDHm9L0nBM5ZN4p7AQXrS+RvDMSYp00/eWff6qr2EpX6f05uYl2336GRJhrq0ED9dmV7Cw0UxrfDN3RWyavXBPLRiB9/2YnaxzBQZkkNOtJPfSJk4JHEeN7Yx54keo0Rtmq9OwgHzOevAFiMXN+Pb0Hs4NOSqFUWYkrkgwYfQV5tQxMmGP+U+lN3BiIsOkStl65tEd6dLExt5SIRj5EYHutb4wm81Dyn4KNi2J1uFw8OFf4y7U5wOvd654+bg4d02fcEtHRzzRY9T+Vze0rV2Nb9dl7iISO9ywHHe4PvfSro0syizWmbk1AbuJBYCBqkPZorZqutQvQ8PMSvwyzyQxbXgX9d+MZGsIzB3AU31zzKZHfypro8MG+UZLsfmDeQGljEqO6KxplOo0qlH5DOvOQ/ILTa4Qd53PuCZXjmUCVcf9sSDdB30yq7+VpB4asTE1+6o3t11TNzIpTKv3qgquzj6qlDiOsn5PVwhYRksYBRfRIoKg9vYVl5jCcM8v11eOFnepXCBYKS724/hdSqE8lzTP1DOSDUz5kHXr0zp6ArUEys5y0b5cznZmJqTT2fdgmg1hGJPy3gNoGgRrPzs8YyiPtnhhtTmLUo19oKqRt0PFRt/7rDDp7LwA+3OjPxmrs/eg3zKjdV5S9ouuIC/SIdJxsr4eUqw/k+kKaz6zLrw3kpezcSlI8l9iYiGr9lfpdqDUiubWD+8IkqTOxzxZtE1PhwXkZus2XBPzwR4gmfEiUiQ4a2Jr7QJ0QlJLafmG81DmSlg74/AsXaatif0SKWAqCNfwClJeqCcXObvHruCyPrLThwRFwZZ/GFFSfKu0eyx48o33aTQzTae46FDDSZAocSGsnI/dHGf+brWL9lmYcr0SsaEGqCLzmiSyqKl3DnF45AnreWvf5b6cZ0ragzs4/iHwv441RQ6LexlIbdAQL5Hgb/Wgjrhaj3LM0FuA8GjtQzQjmwmP1SBF7C5yYhz/EsiUngGxlm8AnjHLM3LksTBglv9mR28RXnKGgAiGXjGubRYl2XHdjZ01j2Ey6kSw5G3wTAqvq0LzsWGhe0QH1XIGxfdddOrvBkxDEeR8CCFKiOIiq/EMvnbVofYI69SLbhoyguYFyYf/7aC6NSElPmrCW2yGWnPDyQ9KezC60SRbVlWCt6IXOkSAQ9htFHnZPe7qhRjgcM4rUIjjWK1qT+ZeYHs6B0HlsoOsML1XEjpXJ6iRJFZKskHcnLZCsa7jIhhSEInltkSTjMEQIm4thZ7VFikiSIbCMyu/metjLUYnCZjXnKOo4/p7bPWqsK/suWChZM/ck4k/2WRUIqOBQMQTNpmYeoVEKihkMK/dZICOzoofFPeDojvgFJsb2OXA4Ojkpvos8g8jCQuWJFXzEHCin4/cN2reZv0lEjjQj7fOCkbjk3BiFCxnxqiBSe8jrJKNl4dwPdXJs3N9bMETUh2uY1qGinG5RD4G5wn24tL76mkFNfG72C0C53nKRdJE0nFCnLI2jvBndLpMUF52n0hpGK1omiRpVHXei7hUGHKReby9GRZjNPz7tFPwdTX0Bf8IP23rMzjMMulqbhohOIJ1wVT5vl+9ueU0AUE0YV/Beqe7ufaJZX7GPgIae65eH8Jd419D7FVVuYNOGQHJYdMlAosKQk0UA0WU3tP824C9yvj+cF9EkrFG9NK3DNORVmSMfX+fHalSx2B1QljN93htdVV93T2lpqpEjyFk1MHOYC4WziK5wbcR7JGJMP22wCuguV6yZL173y7ceXyHVYPQiL69l7kmy4il0w/J6TUbzjkc4YYlk6fhLT0l7QrjSSily9ijqeNeOdEUpfyc3NRZgJFGTZpFFVOoV2CNo3K8t7YcK3yj5etlnLOSc4Syc3f6/Mgs7SFRGb6fwe2WMHncZXXmDF2Auqfi6TPpMgPcOAPZte9m/eEFZEfCWlDhw0dBgrOSj/zgNtzIQEd0R5YgVU2LdxnjFYojWU/7RSfEGsGjzZfdOdCLv9lxoDYOVfbr7WHE4J83WQoR4crhH/hXNL0v1ls/j1DZqczdHOaTse5c2/+Io7EqT7dkIldUalpEyjONoLZ/WPTG6JQZx54S3xyE43faNhhEkJmZhRF4/FvxY/pETGpCdUj10+CD9VFCegwAsynTqL6lwcIHzfBea+dvSlV7Fxk6zYLzTlkUHa5WlJ630AnTEPASIRr0E/2HGH9R5ueMyMUvARehJnFjpZ35iYolX4brHe8g/Y95He2WDYQqLF5XT0tXVogK6sJXaZMs2y8EUG7BbtLbJ9rH+oFT4khNjPcDSZHqlAo5QaNUPicE8OA9OyQh1QDNSLGEa9e7rsYYHeJe2TUY8+70YCLLBHXkGNq2hREXMeRDKeyxNfdaAGziqGQQXVQAJG4c9Fm2AnQ5UAyLi3cmSwBxyBys+AoZBlb+OsXvxOT6dlZmUnCZQu85/pl4pZlWV+5V/1HSHqY+6/qcz/Fqy0CFXYLD0T5rP5+fIjnyF92mMvvmXx04Kk5UkbIC3Q6sAwqNqwOWO4fc4M8ro92DfF84OHUpLMhcknkBvsPEmi0qIkq9vji/qNEkJRZGuaCwTNPjBoM1l4BbeO/3yOxpAK04CnHseGVb2qI50ZgZgxA7SQoHI4aogUSd3HCRwU+LUyrpmi9Y8aALNU2MREt90oGN/jqKtVOSbciaEtMUU6FEcHtvL4q5hoeqcAK/NJkrLdKClIxYFdpfMkvNANLHQpX3W2gpkpL4OzMwEVPsJSt0g8rzcpfBtK05XRoUr3oEBFMd0Z+AL3YE2IDZt3adJiSRwmEq+wkDfJAjU6w+taS5YSc1F1odp0Wot/yUzIZfDkOdsAdLruigFBsNasy4GWhT4LIoGyAt7p229UUlqIgJ/fdm22R+hjj87oBHZri2RHturbLXnLdkKjVKXxopOwTiwkhOMcY7N99aH+txD26myaFdwoqunyJDTmQXfjKe+95isOAF0Op/ZohecXIf0P+lDwKi/DiBSg8fkvQVtiNUyKaDT7FdZyXhaEBJyk9VzL3mIspWC5JWo14PCHeEkWb8uwukHWPII8rqJm79/MgaTOga37cpH3kL+EHFQYuHHOjuvKHJqWIWdS1PFFibWwgx8cpchjkz/58nOTd6tklwcV2v38PrpkZ4sNZiOTlaoz0QfQs019coaQyVXQxdN6JF0OTzJsRwPA9YYdtFt2TXD3/P4iF+/ShpkUy1wiWSSywt8aogjmj9OWgmUxU9TueUbGkVGQH0ByFmj812zIOieWewn9yVeY4+uHxJc0lmGS/sejJ0QvJQonZLBE3qnbL8g8L1cxzne0eZ1rxjlTlVTg5fwIB7l6Pu2kAJJeFSjfkMl02UeMJGYZgtYKSQ8m67DQMT3KjBaf72cYI+m/xkTNb9tFOCk/kkU3wrbqvm2N6kGwaNTi59HhabOWbdfmlI1jJ7Nhu9L+ImMW8YDrq7tsQBLSub+dksOP4fsMTA+2fjvwU9NGOBqrnNYJE3Aw8vcAS/iy6vHlFNXqmCKsy0K3GudNm4MBGIGxpcjNG41PD6IVGONXk96p/f9OjjPZU9XljMPqNfrHJ2fmLSj5QTYRtVoO6qjyLENJ8AORcVrtkNQjfO/frGQ2MQP5L6miS2b3kPGc50U9VNsjpQEqkfiXhmXRPKAD2pbULqG3ZymWZsW2ty9qakzMSprBAjYO99IfoToFh3uZKFwow0n4XEkuucMcYvURiYpDZNTEkHUts4yH/NcWoA+KmNjAGRoSqr+D1ir2fSdZ/HohAfbdXUQ7nBBDkgAYTARrucY5oqW7sneDWinhhW/eb74dEku3ZEGEv8NG01kzcou3RTPNTQJNaSL+fMgJXpcI51gXdK5gq6pW6ohdnNHDJufCpBFigQAINj24DQpFoTgUaHuP5yb/TMwlglW7f28sJS6rcxjeEriqBLdiS6Vk6RUL3T5LoeU/LyFJ5V9lO3IFc/WXvFrAN2tcC56oZ1F5Gk8T9nbe50z0ovsTRGqy0IoJ1YuSf3OmwdsDl7TsBIiRXa9PYg5wj4YRUivKuEPgKxqwpKLQ9voB4eE2JBsWc1u2j6cDH6/pplSiMgFc+WriwdfabSCqhDB85v1YlNrPXqXVQ8H9DjgZ9I2WDt+0BWKPGFz4jCasz+qGbb3c+nqWlaE9NtExr2IuiRHVGo7lPSHXBMru4M/TGutM3ViLs6NvgI1O5/UyP0NSbFT8N8sYoWoyKhahkj+DymJHFKGRGsEmncyKtqyrlJP2R+ICNkvffZN8OLP7RqA4BJ2hbiG7XFS9Rmp3xnb8dl0dKCgGevq4ycyofQO+pxvIuI2rrRj/Eel31/vv/Kh2CezPNzEEtlodvCzpPIGsYvWCGtf1sIBgEwXU7x1ovE1CGZvDn7BoVUZD2zOetnxhQgO8f0Uyip6B33DaF6Rf0ZbcQDW4m6YgVCeNtw06l/rL8VFwwh2ohkdbahkRa7z/a/T2ycQziHZKtQr/vnsHdkJZepOeszjvigGKeDam7kp8gTU2lYAHUokETPSaBKCFXTJeavhb6mXXQYc2C/9QElMa0ieGNX7huQ19zf1rJMpByFPJ84BtIjrQkTbyha9fYCQscJixstLYfRWs9znCOM66SFhz02uX71oCNteBWERr3hqe/EhoKXhTLDOM9KNVeQCMJW5Osp6DuDXwIytC6Rh6zrGi/LRqb7fZQ05Pt7rt+F0R3hyh/KWzV53D98TOucDfX30VVJB5Pkk46tgzXEdutaiIicRDtGbt2VdC+3W84+UI474MfauHaltBLIOTxDz9sGiI60PK8qsxEcfN8Epn3m8TQOiBycg4nbfF81neN0pN2h+UGUgyDg3lr9dxMzhL7c46oZud5pXw5oa6lqCr2SDVSyNrk3mUjPQRrbdUWjC0DhdIKFVdKKJg5l+R+/eABVBV83rPMs2dssShn23tlcVROWkrseaDyLQlYsbkadqU6aQwKqaVwirYseMYPh1AfvaXpswmQ+dmoPqab6S+Z6exqIE3Cb0I7ofnXgRFCR7RYiD23ldvvKy+2TEI3SLj2+7VdPi1wqulFyKy9/KZN77FVrH7s1UGpDRxrQF7PNxWxVh57Mg6gQ6JloYtYx6hyTe7ZkRxvzW9UVh62cVb7JGsP9nhsFIZaYH6HhoVDDyJh72tiVVprnXG7SeUrgZL1iX0UrEOkyt4Km55vqoLaJKBu1+/iq4SgLjk3VtyfYc9EGLRUozVQetUc2Fm+xpornSJl3vrSbeA8zhwOHLGipGDrrNAn+PE+p3gzvpykoVX46JdjOe4u+h3CkMPhyof9cK3IvvjgUMRaYdqV/CUWY0rzUwx9YEDiPvkzl3mZFZuVUPvfcEjuY2BNWW9CTUSkhK5IZ/MSILouiTWuO4L0tFG9HlYzSlv5OuElBL7WxKzkUTbE2og50mKU9j3CJnLQMu62Yucnc00ov9ug8rYIZCTqVeFyqbXeFa9l3cuBcGk+drFgbrMXhzMPayGzrhxcNeQssuy4sEF9Clm581oCuU5GYA9vF2DURh4WFUh7v4eF5ttYLnEqJ/674UM2gBipzzu+SOXaybBsv20Eat8lYNwtefsvwjYt7Ow/mPeswp902ieDuvcxG+Jl+0gZGYHXQ+tLlrmpjzVH1URXcp/1fpGqjburo+Hg+5qEOkilaEsXlT4wH4Dmh4FU/86co/TJpjUkU+wKlnXC/YiPbYUHPlx1euEJApAGrfF+2HNsoW35WQ7NBNy3QUMokReCJeM44J+SrfBw6QqVx/S1M6JtFGuC7qdgQHY3aeMOFJGDrP/d8yJkWFZjyWlthtbBu8FX8kHUonVoqoIyJGuPhSGHdgIXFoaNFvVde5SlflS3EaisFRbRr+qfsERUQijwPQnuEDShUUujxlrocdSyj9/hzp85R2cawuZjjuzdBIJujdwUncF5WLQgtzAT2S95mF/t9k9NT9R9ZvN33hecuJuY5otlqn8/U5O8Ke2HSZwfD0pvEEvwwii+2BIipnTFItoG6EmEU3ZkdlPyJtFfPVhiEF6shS3mBhNC2TttGxqRljmE5kn+So0S7G07ulN/M9pz1jf+lJb8YPaFWOYBfcWukqsLyfgtfM0tnoCZeBMJp5FIU6IDQ9qEttr9QGQ18QsLH3cm2q9Md0w1Azf/DVn6YZarDQej6YW1dtxuDvTamFzlAhLh+L6pBE1GlgxdF1De8AAggOVJrQIICOvEPPXv3KViLPYT77sODhfjp2nqBG6S0YKsMb4/Ei39q8luVpfiQCjX32ppQeER9Ruv+kbfSyPkVfHhANeL7mgw+NganLlJj/6zN7NsBJQY1HDs5MSbUcQW+YJQ94437Yd1OWapQMF7zKJyv4CzCFJAChYGamV3m97w+JuwzFa3zRiFjnbJzyfIry2wb2QLMHb+AJdiSks8U7N/p4aL7dPha8BrQTnUqGyA2h6hB7XfuS3m6tYOp2cmVkfvX4NqvK8ujV/ISomqvCniidcFQ6YdBQRF7MI5H8qJAna20hLhfW1ZNGgulhYizc9WVXW8VgYlQ+KJznD93j0PxVHrYk0dwl71+n5lLhYAxf/Jq0RNcyckmcNeLdj3gUqQ+7/wyMX5aov30hKY918cKA91ajI0xCFsw8NV6PokHrRpE48MCfZWmzf7Ro0wAqYqNBat0kb8zRnaH7/90xAzw4KXZsYUm+88Bdn67Lv3yubNHXLSFw90z536m6kRnynJSXg9Sv8XctI+/TMRTJDr3lyfo61TlGJ44438QV9q0RG6WfhumD6iscHSPo+x91mxC+3eSLI/4bL4UJxKWFQKLP1PIHEQeh2+rQo0MBaTeteiGn30IQiPufMjbFMRJ2vLFrDTL2YiRBvgY8mtBNk2s0f8kEEWf+ExnIeJBMjD5ObMFYJqoHUEQGDolzhmd4uX1SKWB4p+Aa4lMoJi0hgQXVXJdOq9hfo0Nw96YoHSYWLUwVuyDFj4cUO6JDKNxMjtHlvAHI8+4MyFXEHJnjJvywV+ijHlzwyjAbMVcm1tg6o0LBzdxZx/M5veBDya7KeuKUw75Ifa6mBKyCkmpmzrIgBOHY6FdjuGmXKJhLLYZzXOFdZCX4cy7N/25Bf9h0WVPovbbC84suSZ9Q18zEmTDeBaH0IBeSIzUsHq7TIsJ+c7T9FvYPQcyTxIb0O53dswfxHZaHgH4mbgtf6fUFGMVWnM1tDU2Gy/VwPedTuZGCeYZ2ySKtBxpCkq09DCZvb7DuXtKxQgq2GedZipuQZS6wrJ1Akr9eVx/3FxkljHdBp53cW5Ia4HPNIHIRT/psDVqTMXaKOl7s1nudUkFlH/kFVXlLKKpQBypbbdHiXyASNt04ihUlpKpaqyGAQbPs/zmIYZ+G4R3afka77x04+SO+P9Bxq23tncPSax5P1NnpBHRK9FDZrkgbLZ0et34BNqfDmnyXb6Mx0GQTSaWlik5rDf1ySX55Lf+6tc2Bc1jJw6jXwl1ml6xFlh7EO5Xl1FeV/LoHq7LNxdE6uPyDh7hqMDN/RPTne+FGle4MYXGPeBMDTSYD2iiHwkaSxhIbRuCNwN41bxN81wUcprvC0t0ixzFqT8JVsSvGftmz0R1k2IOSJujBLga7jjs8Hj164dbPpnel5GmIeFE3+DCW5OkSdTpdJPsK3KhHSIiwei1PWAf4ViZlOFipANKBcr3lgtLh8+fzNw8beANdFyZKNsu9rwJRWNm4fUkM/KbzVcgUN/ZCgifKXsYWng9s63pjIHhxwrSccDjII1B698YGm+Z3iFpr1quX9kI6rbF+DWxRyZwNlPmZmWnOF20MMrUzyc6AWFdyWr69uj3DfAkAngmhO3PTrqjIf/yj6z0ApzJGCo7oeGYC9LSb2QVHl+rs0mE7/uG/VlNwh3QC2z4Nv/ZyzLcTVFyiJcNbcv/WWCQrHoh57D1HB95CvKMgR7CEdQay3SjBWjZY2i4gX22L5xlAAqi3M9xtlXwGh/2Envu7Ee3umxceszBPr2frQR14E2UtfJWdVV+oZomG2oW4n1rdAvTMV0+SDGkOCczEe8iKYY1yTQ1omTqTEShkTMr2eQh3yayamB/EJI3VstbJVlOk9t0HaqkEksrbCwwFID898QzCv0m9H/qPg1c9Yq0czWFQQLxpa3zqnMXwUW+vu5niQkzdq3UFKKavS7/0lqpF7ZyJTlu+5H8OGWXTcwujtvL1U096Rw/2N5n5HDELD8PfWg2RJmtqtVvOx+TTtchDAEe6+VuhutNDaaC3kVWoFdI2IkaBDH1jhCtghj8I76ASkA0BuqSLC9VqF74jlBys/D2UO43NrxMCDWdYwpyal0SlCPLyOvky7IsQ/9T3kGfiPQSPZm6w5TeUDf/sWuGMOJX/l4ieWU/kLQy0OQOcCyH2JEvi/TXCyVLVd0pgJyCvGXnN6NHwvO1KoIgg/mUbeSi5dnlMQpe07DIN+0EdkL69lORuKfTy2QPWBaqRWB6I5iw7a3Pr74QGYWIk4A1QvRGPT5QAH4n0/ggUyaBQggAsj7R7+vFJUM4gR4KxhCGw/7RJoqaVpGv2euAYPY7sTOOZaYLt5RTYLERSTFNz5wRgItAJYVGK4USExqoTvQ3Gpr+Bwf57NX7iKmN2ikG5e2WIOTXvt9drpVXDlLPf7q9TP6wevwaG+10vLCsYcNji0hePvU6VzLUY8UrwSMZPQkUTIKD4IaIlrDCf/bYFSv91gtAq28O44mZsdxtai4xB5zHOgMTtRKywAwsvQy3N7dKXRUyVFyCHoFzhRJ5OJY22U7iim9NfyCh99b6S17r9xhdNDw3QsplXuvhqHNfSu9wzAe+zMSMMnL6IkY2Zto+MDf0RRlEDBFvy7T4WA/h/Q9yOstUziXXFQfCqJG0fDm8zgGnZGPEMeSY5BRKDWz9iNfharnhX5iFihWVcvkcbdgReAosR6jvfl2o6XDIM9AIP1u4GSUko9EQbdYnN0iRRUf0HQH/yfTrJfJtz9ekMuJYB5Ogo4x/aYh2+ECup0dyaMDkrLEZov1QcCTjtY+7umerJsM9O3Emk/3vQcZre5e1sQA+Rha4iqkNt0nBhhxZIlm5hXOuZPasQs687JZXlbe42xSm+XZm5pPOa/HyBn+zbXwpwwR0sFEEbNijdmeaQ5MfRZNCmK7/gdXUqaAT2uBgetalRQ8ftqt8GIaA+2v4r0KCc79oVXCnvlyD+2/r10OTmyjoLO0wHN5vJVqWYYn2DabjYfN1uwv8Ogx50BaTivvJ/G8cG42F3L/7lxCpm3YvLiUFVq5IZFIjdViyE9hezxxChqG/UzsGmHZ86CYu4KrQSETDNQPA63Jj0sYyit+j7UdiJ6dJ3XN7T27s3yQdJ/fRlznVXeZpU5Pxj/FSJkF8XpcI0/SljRs7B+6dTxvIO37LPdLlMFSwaJSfnSuc2daFTSOpdXCwHop5Bs84nhKQmR8sF8ewji2UJDp8OnlWd0CnDqEeoJe/k7c7xxSft3GcOTVuyLF5SebAhU3e922R+MPIdEid5V+OaY32hm7QAApEQj/bRRAos1kD/FQ5ji63FMyrSsGokyYKCy6CaO6lo09K3wpbjJrNtVFenjE3NoG40WfiUM498sOwlGgA6gyTuFmJiq7L0S3kZR5rjygI9OFi9lyQ7YJ8aV+NiFVHkcbfb4VExWH/Gv/D3f76oMzOMNbSj/CkilQWWT27e91BZjYcx/b0cuBkyfC/znlYpUpCT7xankhzB0qRXSXRcVYTJMLf2SspIqapg5G37tHQoXZPoZSDvOK6QHayC+D8BKsCUbhUQ/8YUMkX1vaeLhd5cQA3V2x1GCMjQyB3WGzTx5fg/p95qMHYPrV7FpOKOcYUcWSO0fBoalbiWJZ/r8FkqlpAOVU1CsmnN0LJq4QfK5H5HrnqZ1nQWghzHB9EJUH89lkSi8tRD/FMQ/qcA2l4zawwQ4UWPhV9lWKueC/mhydtZGX3bJz52T3yH0mYZMu/BBHaaMI+5xg7e+7idyrT6fx1lDAHT7nm4crMbN+qdwW9hS2yYpO4fGR3nnnZYE5hXLXZwp8ku/vSpnsSZ7lamQedInWX/E6+dgPnIUstSJs7r+YJyYJOdvsaz9wwtQmFS6Em+F5dYiCLlWJf2LM8Oy2fuGnocY8gfKoPT7JiHUcPWw6Swi6K9KH0LLrfLj3/0U9KZszHJ61scjAS/yEMju3eOuTLMlq5pEm5uvR1kpI76zdX5RaxzM8hni5YC5Kx76MVVgZowkF4gf04C8AmwZ9ITJXxJy9H14o50wRfmC+zREYFsG40dxsGWnhvCtylvNEkdDiPZ8x2jaZbAOKtP/txFpIlU2WjMThYiapz0Yebx416fiJvSW1NJK9COAwRM7e/dE+BJ5ULplInfpzD0hKo8F7GsQ7YE1RQCcYAGP3L7FbZVtpzN+oqRvTF3IVDc7CQVQ90ZGDCY1wL27bq7sb2Dv0ZVbSEYnjx9PD/D6x66noZvlj/tSyf9qGpKtQN8LfNowstcZTNqlYzuUFOpXHd4RIq28lboJneSdtfAom44S6dyzXvbOa6hW/hACyGum7kqsMc5Al7NVwbrlOTRtlFDgi2zfGMoj0OYEa62bMXzd+uY6/lLCyYq92sf3Vju8D1PMxfpTn6ySvPGCnoSI5FPRw7ORCDaCzoZaMbaTroSEWzTWiUs4RZ3gTziUsgS8zJGLnItzNIdcniSbTI3VU1rwWChFI4UlZRiGOvMJ2jkP1NDopGPdQw7X/QuuxunNsSxV4q1AXcbqvgjdAqVnCDXGL5GOaa3ZO7wxanhn+8aqIeSef/VNfqHMygFI+RssVDhU+OLMdBE21akhuEotFNoMUGxNkBto4TwrCdxhuz5q78fo5nKIwm7lSQ2DdA+vl2AWihbxYpNRiQ0497pvyaAOtAsHiXMUuqZiFrNLXaGHdfRxIYFhabBlHRS7Rgx0aWRrDiW6Ys9AOjYWMFw5e+EyYDYUn3MrbTeNE262yL/n/d3Fcnygs/QKY113Naho/698yDodfT0MIunlMqkZ/fXcekob+E7aB/uzabP0jZX28HnQObPSQ45CBifm2XB1KDiPWKTfPQRNnwPQ120U/+p9PELhOUuDvfL8JWrNYqKD1FLLlNIqGDueIHORLDakRSq4Os/9BFGnlEMINjfME2tiMihchjsNJ6E+hYpBMw530+fEdpokOc50+Sq2+Ty7gcbjAOdSscggQburHr0amAywyke2N9UytUPedpU03ErtjRl2+8PVmA4/PAbG+QDda5bP0Pk7FBTilyHj6j+UK8iHaTVcTNDpufYnGD76DTMM/N8enFuc2IKIJqup28gZfKOAurGksGz8nwAG1ipkiyXghzp5nv3iooV0EpKQC30eOpynHhTmC3iFnPY1T5AV6NerY+goXL259l8fNCxLS2m45V/K62nCCQ8PnlsrrMDpnS+bTt1fdRTBf3gYZ0WysUgQOAc3Jw/E3KtzgTyrk0uQVx65OGOPXavwYlcSJxcnY70mpk4KPh8ggG51avd2caMgCFbVAaShC6tDeA8y4IaFB+KFi3PbudJHbS9YXhCkqoZWAUefl+iGDgQ4tea3YySJr6Lvt2nl/i+X33LbRW2gUAvnjBYfb/6gdydqcVcpGauiPZrKvgSbHYbcMamdLklKcSrSlcbAS/GBpJRyOebgunPnKRxYoRZ3ltbZs6Skf7eUMXj4M/b12S6RgtSfHk7oTRC/d+qajm5fMLSmTLvdHFPVM/rdR4/5eY0KCYE5z1c4k1hz+4uWvCA9r2/7/Ln7XnILU9yyLmS1MoliwtxrDTu49+ArFJ0jgx8bkZbweo2RvnvJsX6pj3+iesJHOzqKTZJIGJDeGQ4lrzsVDPfsFDTE5mVN8LKahoycEoQqxtRbkReoa9MVYYHDOn1mxbXMxwWQYSFLVsr/atNnXb6cXX3zFZsTb9guRj6AJijCIKTiaJB441hxf5sg89BskzzQIVye+lAaqHZcyYJMezMtDAK03qXa4jq11ozigdqEpiiP7+lpHeBmuqqbAXLhFn6jrazjhxdSpv7coKWING+kpnYS6pmVeLlOZpfEWY14E2y7nJwl/ZSCMDWleHB/wDatZf91eS5z4GWIXlouSzeOVImHvSNFKSq1KamixzAZDJ6F6jhDXrJreplcftV0k1g6+TRm3yP3OsY4L++ytIqmLKPM9m+hPVV34/t9U9w+tJhc4BfJofJRT4vejKKjkKYagW8SOD/1zFmSY31ZOfTHslzgi1RNcZy2dQO3o69VOOs9ZjpbXiXp0zvBoOxW31TV9BusCEIE4FpwQ/iEJOghnZ5femh620FN4/HdW1vgkiVlDJB/k8KWBsCAQZ85vEFjouyUmiMA7jRpNNsA+Tge6caO3xm54VBph8qxjlBOgI0c30m1UBYzDh/jGY7BPKf9NJCgc1jadV/ZX9d2H9CAhTynOGcFLcbaHL6H5JmGqZBHcjgKpZUvNptPZCf+sNk/5w5qA8m9y0OCmjo2JJKdZ9M5Tf+OPRF9X9WQ8CqFnXGj7/7VSE1OysUuZVk1RHj8r3/p1IP4DIjGZQEYHxo6lJpgTvwBRe5udqjAPbam/M7Lb2ucXzqMoK09Uh2scyLoqZKvmQjvZeVd/NNJAu4PzIs+PJi8CcX30DErIvZDU5e6G1EWVdSJSYFUdlahwMHvOCEZkPe9H5BQb1KkxURTqw6cdTRnIG8ezLQy3eHddjC+vGyyZt1nsTSBXitKmvUoBKptzCmrOHIcoejay2fQBvGAFC6/u1Y1LAZZn19U1TUxGGxu+gkSyaJm5xAkafFINjaAdbofQvEq9Bir5VxnQZEfaX717G5oQqumbSmohHF+kIkG99PJKE4Xmj9ZHgsWCSR0JIjU6BEdLyXWvJ2H1ymfHPN5auwkhGig//Ct9qcuk7amu+BfcDWOYYRJIKd2B72hY9rBqdO88pz7MYeCsigIjE5rbgxNS+jZCbo6ZHQhMnsA8reSVza4Cxfujfhy6eotk+HC4XJe8N1hBA/YfZMlC2I1nr4IFdun7qwLQHEWDsqgicwJcrDJWhjK8FmCUsbSRAaOMavuG1V16RfjRS0j9itS/MBNp70mKk87OJmk/sdINxDcm3Xw6Y+8ruBm6+g/xkURgMWcoHj3vrsBENIIA8ieEth4iN+D45xhW/5QFf98jfqzzBeEy9BeYL+IKaIOg4M416K0Dp7NQGK/izHEierD7Jqpt8jJyDYKN2pROKJ+ojN46DvXtkee4ECXxaYjngcF6o53spTCm5VY/S5hx9F8SVlmAcsz8AyF1kmUj/MqRQiI7/V5X3NhMEAZUcCISt3MfW5T8oqDX4CvWWyvrnlYMg4pqARy7cSL8nemI1jAoRBx1qf9QYnjXxEzkv3Ov7mf21+/PbdaBJG/NzI7Gfh+b4i/7x54lUhkfGwmPG6c0k7zdawo9YPTYi/grbB6lEcDVa8tmoSJG/IUoJ7yIO74alo94qYn94L868VFSUOg3NaN6FrFc/IIcmj/rFIwUSpRd9m4J4YwVCFAq13zFvj8ueRb8iSKZAlaK/dudnYfLqL3aUeh1YZd5W9gsa+OhFTVqxxoPFfMmD7LLBDACBztQsBXCGjdgtQoaALVrIaKFgBg0c6Dj6wgNms3oGeqBwVlQjFQn2FGMdnUTo6B+lgtHBQHGN5u6TAjvrm5ljK7/iWzuCUDq80+46TxV9xebZcaBTlfQk37Fhq9oJLBKsvwpb5mxE9uYOeY0e098DDGEOJhy4Xgb4cwuJ9EEIy4v2tg2WhY0x42RF0XhvWpZE+TukG6vI/kaCVwMRGSdtbCa5P8an9mYvT5C9AcR8f+hr+8OfdZCfQn2j4Ff1ZMH/PP4e5taTSUSHNRBIdUp4yuDqylGMCUMSDg+xkAq94NLx6/fQAlSSbLHTYjtWaEQ4Gc7vpjz2fIB1d4O6PfOoOZDlWjze2s+U6lqWqDROjhrRl+IkYHkCsmVqGOKi+S93k2LPp2DuMwwsYw+KnHxhSO5oBUCbHUQ1VI1/TkidpeC9BoNt9JpdXYsv8xEuBwZxqlCbNWH19GDSr4LB1HEXKDFOKkpqiHUoTwTx/1pU/ANw2aB+GfKy2n7RinXvn9wG0/mVmilZCHo4u4UVOn5IfvC45iavx9k39yNOOAj7T3ILz3c81kM2nv3HalhdmZx3+LJY47fzCPKQ/iYdTtl0TtRfTWRP700B3+iy+TaR2O/t3EJxwiwScWOPqKsTihKuzh8Wpngu8BeBYI1YyZdcdlozWKSVng0sS4L+oHbB8qHEtYWigHqrCL5/Ss414m+SsCsMnhiuirQ2VW8ZKay9qC1vP5voBKl+oJEs5r6YvcNJfQ6wYAjYVrD8XUD4I96BpPNFRmshKXnshahj0GvPZfunPxu1KoTLmaZT+AcgRN9tfMhNBCSunYA1JCPTVg4Wkvq6Cx2u77nFPPLFHtF6tmWEx9pNwkzoAkEjD/FNbBw3+rQ/PrbyOkSePQ9I3gjVME3UdoVSdkGk87ntHseBrLsIi+cGplYHlygZW0yUhv1T0knRZPk5K3zGz6wOVb5w5SiPbDyPt9pM1fOGSH2E0JCMitmqoM14GZz7NfSCudIXK0Fb2OYsiVFbAhPm4VEnshlqIAlbzE5nJ6O1fQ2F/b2zY5XPPOv7NZfghJL4W42Oa2kBC5bJ1S/YjPs8VhfmIAfgIsLNC4q56hf5+8eePI2KrXlPoOx0nd36NKzl7SLBvDLI2+QPtEAuKt9tFK42JZLMx8/F8SMHxsn5IE4tRHslAlFpAOeThlwDCUjM7Dx2hDb+QSWA9CgGvhLEplodV9sK6uhce8NEoHDDzcUAAIpTEVrM09BeNsAzCOmXp0bqdpIWmXC5SNi6xITg8rS8E6g511gtrVUUgFzbppr+PCkv4uK2+cpIxhUdyDSYDwoN9gFumqc7C5l9UvkfmZ9bs58GLoYMHQ4Ju66dVk32MG319f+lVMnwBxtI8XW4AqzImdUXSfmRpFzwcwDMcgpLBiT/i0tDiOBmpotQKDmQod//UzPbmtORpK7s90KMu4WxJ2MHtHgZbzXnigEXuWTjs28LkZGBM9sQH5Oinu7PeiUE/g7Grruh+5xxh34iVtIM1caSsokDegDXZYgXMT3WczZy+8PaDadiwQmS4EQsCep5XeZQqBmIElyVk9dgl5en91fG+StxaYu5Ky4bNJZrRFG37US+qnroLh3Y/UJdgQPssb6LwXrzk38lH/DLVWv43zAwJL7wLLzikgRsqKCDqeUXZSTmofIwYTkxvnq1FZ67YQn2ZVVxjSmIMjmzrLRDmV7Y87uSC0094JVWnVm7R2vuahQabP8iatiPzmJQr304r04WetVWJ50X+bWEgJiijsY2glZyexsGoVggLNycTComNp51KwnuCFtJauii7rnNDQFoYAQaodaJMJS4WGC4oNI9T6jim5PrdQBchV4VPLPmEjyKc5WQHW1m7puZmJd4yDXqgNWdHHtqKoskJBZy1UvoRH9vDHmld4L2sFMAkmrO8P1RAKf4psHApO19OOHsX5ZVIPSV/3xa6qPoJ7cAS3+IfupFmRo5X4p34FTEqplvAdidC/AJn6D26Pd5kx4gu5RklWHJr+NMgDyw2eK99TyCnb1S7IYMA9keNsHNigtcdzjgQxUO9rLaGq9fCN/NBiX4P2b2jtfZlPRlB7G2iXCXLtBdLOpOfI+DXJOhIGitJnT1QAsOYeYrqhW2cxSVxVytE0gFDfMfl6Wroh1GO5l/a0vp7bmi7AdJD+YwQ5J3Auynj2bpH6DU7dP876aWg6f9ZYYT9EYpr2Lwv55/NU8I+qMi7GYK447qNclb/8NCAJCDoZIqP7FvQlm3SE+qD4yMgEVGcyYAryp0PlSgXbOcn59hNoyPUInva7gpoDBj3xwMEQBOsHikk4cPAEdd8GkEVtHyvyHNrwe1UmQksTazpp9QmuvWZ+AGfWV0VVM6psBktCiiI1X6lY3upAFma/MSqNysaay5p8UVBcRXu+o2NLXSkMuSU0PuOuWIqRE4z9uBy7LXrEBt1lrYonZKzq3GfxL6hWwck/jBVlt5ojs/qzwp7aFmCe6D3eoLYTptMX25gFul2/Xjom1zgHVMmwsk6gFeS93jVdv6R+GTCk2RkiNrPbEtED5xc45weJPKqIMYuapb28C/+TWFv39npnM9H2rPFnooFQ5mKAnC7LURA8yplPjFsueF1DX0tFSJGKjMIU+ZETZxWZKLvlJgscut0AHI0+wfO6O+iHjRhUaI1ElkPUv20nQAKfjov2FquMEO+9ox7S5aF7MhHRL3itfZykP2y17iIRijaVglp0NjlZtorz5+frN92eChcSU3FsGPeL8GKkMbbmxuSPlKIOkqrprMXjxa41GqUnm6X7EFCuTOClG7xbR26xzwvyR7darE4Gmdh9U6EOdl0BM8Ba1fuiFNIrmqnw82WliJapjowpTwlU2khlAiKZkWLYFdHMRpTDm2ZNHwUJTBEyfbhlRjRKRYUp5OMw5N0YJYMdSlY71Dl+pN0GJ+t3yKQVuxdihjwVubGSqYMV7iLhXOP2EAMxLLfAjK6klVBcV/eS8r2ckclfAvrhDwuhAmi2Cz+uw1aNry2GVl/MGIYITL5/xvcQICR62gUlBxqHfMdvP/q/0JcWjvlW7ai2RxV/UkT8XHoa0+LwSq7CFQ9RXZT7YussE6ILsQS8zHQcgbGbtqzUzUAVY0lIBENP7zS6Zuz80arCw57mrhloB8M3BrXYIRODJjSUJKN076K5eMJIADwW2GhLnA4DLWtI5ZHvPNhMDrG1Hzbr22HwNwJVqWhKwvXazX6ZCpY/2obmwc3KQl3327b0ZfjIvPy02B7bRVkLr8GTHqBRyWWVh7B5+mOjuMK/bxjcRfftF83dbFJVA/vojQqsWeBw7ii2xsEU1ttrahply4zNq703k2MK4V7r1DdxwpeYFtNUCFJzaT/q+JxOBWLA0EsgrePjXiKFhbyibXq/ug4pd50vSd8HqwaumLoZeJxLvVpoO6m5rHdSrfGdcJT6tO2DZOXY7Sva9IQT14vTu/XO71WDaIYJas9acWtLppVhimsX413wBrL04y+cZ4H5BH8lyouorExgLHXTnD0uI6BaMTLRTAA+eg6nOWai28hC/7bUFrYGvn1TJ8aISihmcuD2ekO+go68IBVRJ+nUJZ/qZ450sy+POKXgJENcrRlVv6szq9O5UgrC+SY7jcXuSUgaYNGr/woeI8SyG41pWhwxmfszK2ZAUIWzXBWnaNI4ILtC3J+yxIkHdeFqkUKhL56l7SJ2Y7jbo0wF2UXucMV73SdA6cIXVXKEqmdy7EIlUEl/i8puH0eF2MtaWCq0M1+Bk46qTHQvAVQdRPVDyjFEkjUzvgHmM4QyGh99k6nTasyhYsUvtdYTCGZqxlippSVmMG7x6VTaMzaTL1BOU0U7+ndHvD1YIoBeQ4W16AdErjH9H+tc/G2AqNxuQH+YS19ScOa9QFSQ3ekx7ex7QSEqxcExTNbvXL/YJotdU+FwCbwj0X6PHlGQNDhlC5js+Bl/gcLYNTivAwL1WrPZfSznWy+TZTESdUnM5Ey+mPt/xu+jhjDJ43Qltfd+9gNTZNu9lg7BvRKpdnINFO9n7uHzJsK6XuCP1oF4H+1HydmU9RdZAJUPzRjq+YXsNs8rMYWZUZkBThzIpUlEYZeY4BLPYxKgguyJmtZoba86c2QGFujtHvBmaISitf6FxBGhCklvfOHCYKvsBc2jD4oeMZOA7SGhryljSiP0xD7aeyOQXHzudkVg+BGQzb0REcrbKsUE9BUd6qf7lQ9fFjN3D0T9jw6nLsctS/4hvzc+a1z1fta33wIs3D4K7l0OJ+/fUQZ5GiQ3Zaxrij/NJSphJe/WfYFhNQowSFIGfPaqH3fTk4/1U4cZJouP41A2kyMs0kX0T21sEVPeN7MO6okl9luKJ/vaBuFvuwAaDlwu0T0MkoyYl582sBwV9f5mpGBzJBetj8NGS2CnhqJ8WVm5IGZhzZ9ZZBsJL0o1fYnkZMnfh+35X4A4KI6gCBOGoFySPM3Ybii6bppvcb4xVppzIth2TECQG3Bjh1NuvvzqZhYrQFmTKKCUnTrE5yPlYyQzTs2BlbHT5Hf+0Jly0If31PWGiSNBSlDUm3YXxZeR+GaDLL6Wzf+pBtu00YKpu2MGec9Li9zF4yA7e07ja5nDFcbuapG5AXYik8QSqdqjeQ8DX6awTfi8qo1N1CmdJJu2kGxcXODs1qpkM+Mm+yV6vTiWrQxmjqDcW4FJErx3dxYM59v9B8bU2y+f8YuOYfA1oI74TG0NX6cMfWc6ol1GpDTLamZatmfavzq3cNchpn6PaGdo9iDob0kUsWJXZSE7VliGde8X15VWwGtSRB2AP1J159oWpyZz2rk2nOqYgp74SG1pq43kKLNpPCvQIVPi6W7IU+97804QPJR7a/taMkkTqiE/QPaw29CHGI1J3pPYlD49M1ThKIV3SY068+Uedis2OVZM3WF6xV83IZRujumg9xSQWUZC72L4JeMXLIDMjhvNDrnbLm29maA0kgfMwHWzQ+4oSo1bZ1kbGzEHHeQhbhMax9060nJsvSybvFZYRRejjaSpc2r9EsRiajPCg7kd4jaL1zdwczEf/JYq0T7EuO5vdbTLr84W8WLr4mkh7Ma3RLxE+9dJYWzHosLIejzNU8969TSAyOjt7xQWS57Zhg1AJ98dQJqbayDfiIRAPjUGrfoGeFe7MQ+2XSEh8OcV8Ydo7Tms3HP1TFtJA131g8X+awf4E9RlL4mxqLhpVSy0jqr+76ZbG56wADb314/4OX6aYOLT+W41PYdYknLJpO2oXMbZkRBP9ezXDn0EIiQ/hpGlDJmcz6Qk6Pw9ec8YgeAlZLwTHkGy+IAGtpxzdzwBy/bE4YF0x8KHuawh6aYuw+/2Yj3IFO+KXEFjVHb6fZ2oUjGy56gmefILk+tkW/TIx40aKn/einjNhI2ANOpszAhywWa8yp3tqbSBFM6PbPRQ45FsTS+4JeTLMifEgCU38HPr5TtKiCDH3rVx8yN1ncQLDe8pRVpJB1cNtBwxhL776bitqZ0YNv6Qi0mrEODtd81HR3ySGpEN39F5pxbElKRn61MGrNkj0m/wfWzn3Ea4B/dQWaVHsPg7yJCEyeFoAOTa5G2c/4vhuexxcM8xo20Vwt8DN9cpYMW9QnRfEOw78tNe1CW5o6g9KGYt2sWZ2RnYmYA6wCr9iRcLH3N+cMq+Z0+b6i2/oGzqy49GOB0nKq4I70xRYyVwpwUsI8azO2eUjXa9E1xDEiRKnn4D7v67V6Ha7XioK8G7eg75bsFyTAWk+ZyQjVVaz/20G9tcHAMlGUduuCXwU0s7KgXNv5mqR539sJ0fORQp4WFOXVmdDcFQa9QIJzzD9Uh4yVCMpIoQUqkr5QiP3/i1zGAoksYvEM7mZzGBNiAArGQbdFXfENpd+gQNLWyze/DlYuBsQ9X3gFFki/0D8Vssr+GQLAS8R82vehVRcdh44TMa9yi6BsF9nYsfTIhTCobZ6yVh4nzn7yRoG1uv+q7g+8al/jm3wo4rnnaqgC6meXuj1QMjy5rNzw6A9/o4J6vUGRokLXBnXHQdy6++Rea6+4+4JK+jkDXC9+KzW+Koq48i2lsfYJr9c48ZTWkof0v4+FJsKjAvLFrW9K4KrTKHuX96oDQghxIiDvqAVW3Bui1p49+0SJOcFL1efy4Lq/0lrt2kfLkInyIPksIS2hWyD4TsGAXg3gWrJ8sEcILSMkxG27aa8JdClHXXknBlYJO0ayxVaD+vl1ZejjXqfO9uJTeikzsraphE0SvR2EsfjMXbNZEEg6XeiEYAY3wJmyRv+tBwNup1iRwZWrpl5IlpvZZ9a2yVAB6rfBT7AlAd+T18lC/rJnTAbhYk/cUCMPYkyrFnPJVYDyJlW5SrihN2SJx57sEXTyYXwa/yCwI//Mygp/a1AMQ+AIVivXLZBvs8s9GzlvV7aWPhVETgsIX2t8M8ZMelMTN4fHVtmqBDHFjZxlyTLFb4HFQtI7cOgXmkDKEq1bAoQp2WOu1S2pUPinz2wDSBl1SllG41dOort9EE4a0xNZOAjiqw0Jv31A+mHSLR0CWT48QCdf12/eh+MLW+VkMN7crtuT1nKHYR1S65ugh5PlLlO7V+/BTY/8OCje1xWQWF6eRFnWlwQeAusrhIa7RRwtlnlA09JSXml7MZCKXyEtMUFGfczL9IlB7ZAtTSmhH4aE1+rNzL6Q1kr5fTvlMORIwfMx2pQ1DrcNEsq47kgewLiPRIWq9DMmtifwq+DfvAlF/sewyEt7+qUqlw9eDNHGmdo9/9jkW1FZcg2W5PVnYNx6BEAK3GC4Lyhg8BMkeUBJCe+405bxt81a7KjAzkFz5CNKmsaVuckvaBVXp8OMQx4d0YJqg8v/BJOVPpnRVPYVndY8i6A/msaDXZCPu8dDwQCq8E5iOwR6/X3ArWKHFiFW0IiPZvLtYHTLXI0lz8I+rb6zRadxFq066LkCJs9umuRxEvC7QGFj9yieidhNyLiR4NItN2ki0x5TtoEaEvArJ19PRL4taLf3vG95GcWhFmiowKjHiy8YW+chK6s7HaOumaa7Vdzo6SczlY/WzCreWFfSKQmhy+uLL1+lA8TTPr3fuqkzv8QmqZZ7kg0XRG3gl+RcgnewjVyae3zxNcDSKuUIXFL8xhJVqDBwHmTaiKP/AeuC8xMNZk+p+LPRy0sAKhjSSm9/JUDCr9AxoUkbkEjDchR4jdHYD+Khu1jdu2pGxB42GFu8hG9f2a6izmzvxKwAPTZGggRrgfQycJiRQ4crCwAqPjcMgQ3ey/qkON+ojYvoN9GShM8C2PhyjZYxFXPIRowUCXmY0/SJ7U/HZyqedj3G9knHBHOKDaVdRkwVC6tAQ0cnmwZ/RvF4Kolu6hHnkH55lRv7adv5wq/ns1kMz2eCirCL1JnwbajPq7p5I67GfYig+3RnOe/fnzdueok7otETbqxp7YNhWCUhly3S1l0qIShXxydCMByHjnsmy9ZKcWVVSmo+lUAPQfpyYvIv83wX1kiuAhUrBuUdK9w5e1AGTAOwCXv2uJvuyOExjutZaDAVEa29X4L8gtdAQoKWP0xMhMnzHzbnq0CRE2E8jp+AEadnbEET+7qRssORy5BD7T4PhFImxi2DQZRoczMYX37fItj4Zd0IGwB+clM6zAwsrBBb4oNpo6VSpPv6KEM5+E0joVpokqKFihFdfKNhN9gKR58ArqsBqLLxC1GVo5z7TY0hlOfUnuHYWZeecW4AKNicMhfM2x+BXI/c8812Nes5FB5I05uE2+6J8eM0ujhi4zqo9iAewbecywUEzyBOTLAn4p+cfnVcFl8QjCET2Rl34/VyEr0yrkSsEv35d0TPrJqn6/oze6MC8J1c/nzc8ZoW/NeUrkPvn/PB++98izGqktOdc0i/uo3mORvsHfnw3y1q8O1M2tiatUPMRHlc77YfJTon9nExRAPJHmbHH70JCJee1qNeJxC6xL6IJhToCjdqMC3jU5WYt+5U4TM50M9Xrda7b2QaMLF5cwGch+SPbG9d5SWeL8qP27G6lLdg7qBq4kpGdFl/6hR3IIPIYEUPQWeGw0dFLtEWh71GHPC5zz+mHJWCtmSS6znKJ6Xm5zdkSN1KzPZwkhckdsNeGWVfiDZVbOE6tHbxbzS5gB4ZYGnD8obUSNWoH4VCVKKoos56k0+fpb3FSwmEg2Vx6UXn/0enIxbr4hVbaP0v+QkI1Zyk8ZYMTSRh18cN54tnB2OsYAqoZtBNmkQvG/+5S1EZCuRpBwTxCxyzI+xTve539PtlNfvWqdWXiBBi/QKGgba0YrH+q/2n6AAxAtjFv7ACPYYnrIN2edKEMWyI/w3j9Y9nbFeyhRGaJtx+bLzLo+2c9bDQaWwahPALn4dp8SyQrq5OYzrHasmpyOg4B0oeIL+YBfGkM72JZDykEycOwrzJeIe2J0JEg0Y2Ybgrkl16fz+tSFn2O/TEVj5dJqJi2ueBOD2bvlaHoI2lcjICI6QVqzCbC+kJH1Ypbv8FIZ6NMMGXVo77V+7dKzjk/TkLfgqdIG+TKi6byKH+qbQOQmW4DgIaAkZ+WHWryhCWTsUxRFwEE1sOeKIsLQXT8m1fQcDegxltfR1ftivixK32v60Ki0pA7JnWL/5UwVFGHzk6jJc1bKic71s3UA/fvds+jVZWpeBOohThVEpfBYZV607bgJqe/uG/EFOPYl7Bt59W5x7c/2RV6XfwzQCTdX7C1lu2pmFW/NTnSxlfJs+fL1gCXVjcaexUXum5YtbWxMgHX+97iXoHW7o/2tB5nR28gc3yBRgOEV3pnbvWDkQFPlXMFnNK/2z4gnMyLcSpd+AG4q8QgfJBKIPGVqVz0v4p1BDJbf8WyYsA1XTB3bwAa7aUMoPdPPf89iVI0GW1tdfB0+YMXz5cyOo6S52mClXqktZ3qd8OGxGRHDzXjP9EsG1Rqx2rrsbwUV6pbQ6HdHO16l5coVj/7MbBoUiVTFIZpyg9BakPKHU1VRAE/2tTcZGwBNZbB9NJFY8ou5pDhEdi0Xi6k/OH6mHPIlwgznNVuZlbS2WpELvBoHsr64URnVQ1so/P84ZWxwCX57Qup4WgVVu0BC6/xVD60gWrkmyjQyTBZwtFifX4FNns5dES4N9os8VI6I4mj0kxfSYBdmZEC9cGo5XzH5eqbJubVbCQYJzgPLxU2q39PWkUee+0JEdz95lEQ+a4+EDUWK5iV7dUB/QBnnkyzCvXWYXjKGxReUdY3oIUVD+zSym+YzxJnekyiXjGAGDa6TR718StCfR4h7mcCO1omEgGuPs3EeOTfO54SHH9X1nPg+xKM50avnSHWRb/Aejv44Gci1pD6d3zCm3+Sn1WyYSFsfBh3+NRKBljTVg0H+ZfWaiOVkKdjFRd373hPDw4B9Nsi85wMNYoDkx5gsrugymWRqv7nUnUVmu0tnFYf3MZfPzu423KiIY7Fb2jGwkmQ0+Co4rz86DHlasP0Mf1Zg8NVppKGe9mJxTMR9xiPvJlrYaokS5Nb/l4rm87+EpDOLAPE+Xait6Z7NfxbcbRL+jPKBK/aHkcdlPOSZRm2hqyT5+r8ZxcQWB5X7bH2ixMBN3arB+z1ZM20LDloFbahWr02YKv+oUZp+QEgAEURYvVBAhBZP+NhdxX8BJ5qLFWqHIxBdj9i6aQMXOeTpC8VX3q2S/iMJ2TuogKyUdoTXKhh1/R0vzGke5HoQA56hnWeF2qV2lPaCwIm5Y1QCdbkkCTfKNs2HN0cu/oZRI9fYEbMst2A7V24W1MMevkygEDvEa0IFKo75riDaq1yL80+jR3qoRyQHb+/38UZhVJwD80CQ1NbDjuaSNEuYjO3Zfq2wVSPfuqCMEZDHeqeYP8ndzG//mLkSMvFHIavN3fAHCCu4VfqkXFPzh8rAmtpGCoYJg9O80SQjOPR8Vn1ZfFj+46DFhUNNDCuX/NcMjOGUMnXYUjv56HInNCSrM4/r1Xx3VrtgAjL+Cknah9ww2gJ12zklBOJaQks/RbmZeg01c+tSPYWrgnsvAYsRZpCAFkejKMOID/AEaP86bkHIUhiVXi/CDWLI1+CPsabG1Kh5r4x83SWgQ3e9w7NtNo4TAmhAOsd0lT4yMs8s49LaRhe2GE1MbRit6ZuaZexUvmVi72pJ/0O7C/nIcbXNCdJSR9D7s9wudf/wy4anUwuX1bUk6hTZdAjka7Li2f9Cv6v9jF/fUGpIBDFappzLvgQIlMa7x253E9nZYg6rk3U6L8LTmuyNe37sbTyGPPgrllWUafvgmiFrisrjp/NcgBH5SAlarnDIQfgwjOncl9ZVuYmUVVt2F6UoPo+2CZRgFgK+2i28MTxRFjlWen++ASppu96vZAHYPYBxarpUDKNNe6aPD45gjaHgKkcmbOQlYxMQuEtzIr/pinF6pLw7AQp3HUEKnPBPDhkPNd6BH0gSUb2+bdbS9cq9ITD+4A/p6lzSyY4Fs2+o2vSrgKP/IKdpNTFP0jt0wYCK4k5xWj6l9ddDH9MnkMq1Cumxc7A9ZwhRDw7t4UHBbEoGSJSr0dmVTlc5wumIYsUr6q5MDRsDMJAZv+r0wzt6KYSc8AOzHiLS9Mdb8Mf5XwSs6Vev3EcNLFSUAus222Cuaw91IfolHYnappj7kNX40bP9UQBbXYVGTPsdK2HdoaxRaDmQ3vKmM/8gKu+6e8dPmh/UwaA5vpK3LUzAVZObLxwcbiXOTtH4PoXxdNbQvcoeDUd95bSDq2qM7qPZ3N2C+LsLLG+Cm/w+/rzOXN/09bSOvHCnlaDR5RezH6wzUCbIl6/nO1vTfcwE0zU8SAA0L4wBETBGzzfyfXMOcaPGna4RLsLGyt2QqD3gzPhKe3EjyAbp07QnfOyeRM88vdnOEljfBy14hV95HN3hww64AGhqbSHcL3pVcy7u8fbpdExIOrD8SXnEMKsZ9uMMz0rpm7bgayiSYvxecuAAYz0BCPSx/yRLOYvyOdS4puYtR+YCZJAmS+Uox361xLto4gGIFIfEv4KTshBNBSpkGXVJ9OrrAYVHHtlMWWA3hJjPKXNEeZzppTJHGX7z9WUsg5sUBP2zlTm6r/Z7eJ+S06gIdbzYmwQkIwLRxryB9wRCcS3fKrMQLPVIwlOXjsQMPWHCyZpTmpiC622blXppMhLP9BJAbZvZaaIvbCZaGBpfKCDm9EIoPABBc687xaBkwVUD0dPxupD7cM8EZT1Hk8kL6Oxm0B80zj9uuez6BftBtWtdix1+GjfyNP5b0Yhhz54cVYt9rfpbEKW0+HIOtFlZzwdUE6wkte89rM6T+H7RCI7NICjHoKKRWWSzwCNVb1Uvj8Ty3xIYRUwa8qusZ8G42m1oEP0jmgUg3nLrBnh75hhz/1+0Dl2e2eD34nkvobK23dFY2/9Ninm3DCSI1bGiURIaEX219eSv8U2LTKe+xRDgpLiwfnz2xDEMeubnczCGhn1/p5mQ4BgFbNWlJKhCujff2OpbD5Vmmiwh30ytceopUfIKxaWv1VhkBVEeAbCs/1vOiBYHVrLcyMB4MOfdmXi7Lnbggt9KO14SewVnwb1zJ48hROqLddY0BypjVMcKAEFQbyGXy2shooVzHPuRGcqXd4sfYsG/1JVx5gVFJqyCMrmphgnVQ0bRzR0M8HwFEi9hKcePa/vpg6rfYGMxtWIfrs1UsacJE2oRC8HYyLTa/cyCOfkpRfSEdFoA6cWUsJ8TNaN5WnSF+2lu7LIW9WyJhehu2iwTncR7xq96+CQxsrNFXrF5B7U362WqTtlwMcknJsGw25i+WyrUhWZ02ow8IEUgCnckaYO5cCsUrGZFn9QS/BJy7FeTCr9/owCKxMkM2c31bJALCWgojnHI/7itMC870UZ8UmR1MMzy9bzyiFWWTxlpANCg/iznK7YDX8rpJIol7+K400N96Ll22MnZfygRNKO0Z6O4CxOcHAeShuQz+zO9K7rNJ3r2ZvhV7FU76czFClS1nX8vB3gZQb4PuzlIOVHp29kN/2SjtbzR/jgMyJ7kf16lzwwuBpzmIjEzpGn6bVQHODqqrbwg8ybQkVSP4EQCiUkTOB3vY/aUkRyl8lWwcllCpjjwcdXJmBUU8Jglz9lHzPuRfLxWkYjNHWJkOt3Kov40lwhFMGxuBDjggumqbfk3JJiCzHsZH2e+se8+oa7CBYu9EN+yxD+MtzoNqrxzYA7qYn7zgvudBq8D4NuNYgZqtn9lYc/xhxUQW/Swqsxn7wk3jS94JXmjOpalRASddpgDdmExVb4Q26v+wB4at1RmsHW4PvA597+sTvWEkB72wz8P+LZkStv+M/iUBGd9U/DUrsoXdKfpGIDj3ZqTHRdkoA2nGvwaEQmItSE6FlUZqkn1bD8z4ghjDE9rmb0hUSECtl+EafHIfmaJRhe7bxxR47Ql4bGPp7C0TXhQ3G2JM9GeRDx3AuFKbp65n2ymv/GV/MolA59I2da19b44nclvV4DJAXNcBJ0+6z05aO2NM5cypLjxMnatstyf4uTNE+TrXQZ2B228QDMvrk9fvSONrZ6ciTn+6gt93IPF54Vpv2yR+1a2q0ATLdRVVOor0ymLCc8AdNNv2U5DbUUcrVRzrlqxWEMXEVLfi2rv8byguqyo/trKeMHoiCHPN+KmWJn8JuWV/eSRdQxXjrQFLojD9lKJS26a5unAsDQf3oq7nrx2moYn+OtOgOiaLxtd0q0jY0krdsju639eiV0oq2iOvlt229xQduw6Ni8PaJM9caW2jKru8x+0HEzMNOXbNSVdioBge1plqYmKWx2r8MOQtVp5EmwQ5bbUzb0w/iC/xfRtXFL5ccOz7L1BlW8K4uXDmDXCQf/tq0wj+UXrxHiNeNo8iPtdBbvh4P+kk2fG9xTReFSSmyo/SMFfRPFMuBsazmVJDngfdzZHOCR+NjC7zHEtMGXSuYuNxNw/rmecjD9V20pjiW1fU5lYf/trISJ2TvsBQY3w/25GtUG1oLgkQv8ABvKNsSIHQ5JyznDFR6UWdNkRMcW79h8MutXNBdkQwGGZe5LxXhM6VIqpM04hEZCvS2q3t2WwdISk1/Hcjp6dpsKBi/J6hC31fnTSvL+BjkqxygjmOAVy6M7upuH6cz7eazQX3AxsrKSG7N6bfQoiPV+JPPxqQ8R5hrhWQs+wXYzjefheeIfIHsoP9x8t/AXZ4B6giP86Y9oXUAyMKFC0xtig5hqlMWXeabMm+G3T4AHN/XknhFPKAyHVAhq2IqgqsJm6tR6bugRY1iTqj4LAFH2k0DyC2nhaSkQUjQvSgS0rD+bBc9EGOI87jj7dGM8fv2WZaTV/r1NCWdgjdNdyqSTZop90ah9pn/oGQQ0rno1ploE1A1PRJ4GaZx+n4KZ48VMNnwZjgaY4FbCPqED7uDij1jKJVaumzrSdc6IwvqZj8c6CX/Myr+erdMdB/koaYXyo66mj5AaoUiLW2W5/3Mof+wRpW7LmbC3VAcgrH2mz3VSKRLoFBJNv8YAiW0+VJY2oND5Ikyzw1/gYe5ODXl2EV+FLAtqfca8BHxMxxiIxitt4VcpBw1h9Mtg7G/ewcoWtNNmuN/ONATrPSJaiI5Wx9ci06kp1dIcsKlcKt8PRkVe0liCXFYZm8hatls6kS1HzE1cyc/aMNpNqxL/Km0BLuw6zZyadx1HReulU3vajhkumWDVt+gLPmmjRdKSN/f5AThT7KTmpsChNEh0AQJCqngyUu6xpU+hkkMF7kOZbzC4gSoeIIZI8LaQ9ZIITg/5DKqaQuvaaaCIibTDXiZw/bjcdbYRmy0xk6AYs22OrU7mg3EtjK10vJ7YLxxpD4od8yXvb/P7hi32ZPMCy4Xia9pdT8uAwnNgY6ekiYrTMma+ZN742wGVEdxhJhlvLmkdpI0OU+ZWO7hwhmpfNiW+2MV8BQ+n9Ovrw4M8aD9GEweEygLsSeyrusstRWrKjuTlMUPHadD92gBleoqiovOMJOvKppzWKSc7OkpJyUnHb+GXNbFvVvtjyaODzwuawLiJZWkClf+ha2KjHOs6Q5b8hAzANTUtlPw9o3mdB7jrM5J4O3fTu40qRe2z1+j5XoWcLYRMx5P/cor1/QK9DrxQ+hijIH/0NCt7oVVUX7jGXJ+e+P2ck7vWXBNIkfY+Isl7CeqhSnIf8J3vQUeudgmi+/+qoLl4fqxoQTuEvKNg980SqkBCHoorf3EbCy0MKniuOsATjE90bAQMjFaU47Pt+jS/FToO1KwsJBaHGSX27CBWJbvRmqHWP9PUmU1ZmhX5HvIQggrtgfmQnEsnPbZjD55Db0iM57hrcWN0xBEWr+vHLjO1UDA2AYS1h76fDVhI97OTa9aT+l6f7J8cEcH5R+j2aKFWyTEv9olTYW8AkGYdRZGo7aE4l9Jn1clX2lj24E9kjFeKO2Wy00yM789E9/uBBubelEKRSo9CgcSzbXDWnGEe+uc+zUr+aa5IQQH6dLBGtpiXoSuyrQ1rkWUDuhWv22nh49gEkCHp2/trk01M9lpIZoKOP+mD5EqujSAH4Vh4hBHwP+HXonVea7Wbcr6ae3NT/VttAL3EV/nj22Dq1nGtWx8WknM1gU5hVmSZyQggDBBAF/jzmAYVk5pKvjI2GtW74w9T9R5KJOJ5p+cS9vvKGWxM5VloQ+Tiz18QJh9CBTdkOCc1Pci8VOk0M8b/WzvY7mjNph1D0KXLK1HQXOWhqBRvJLVTwtI5SD1Ph3Xim+1W8DW/+99e5pgzqpr3tCDzrYRlqAkzkvxmy73wuVTjt7bQr+hKm75PStptqTIYz8Whw7oVi8o8/g5HD+vdObfbODZSReKFAZ0PbEcLJB0tX3t8cQa9Rs/Q7cpz+qtSiaXzo6vCUeHD8Rm1Rvv0KSnuMFf1BFex1NTgN4sUUirZjVvY7mc7SzD6WIC9eRa4WRJZp+OHFuD1ML7UsCB4WUZH3VH9n/T+LLPICurYJ5uX+Poc6zGusYqCeS0i8I95OL0rxTwNoXQ56MxeTgmSPhQmh3f4QsHcA8aPLn2GIGGkB8WUalLnG7nIa2ogG3GMAqqjD5b5O/SOH6mScXClCdBFU7C3wRwhyNVuoL81CSdNzIKu3nfuFk+F/UZAWy2Keh92NFYHotSO65AEQtewOsMGfqKaLinoOYORHT4nOePqWYBaEpZt51lTsz50tHNtfDZ0PYYjQeExwm2YozsM1QTqNsXYg9MjseSlywYIthBs2pkN1kpSTBuO3eZvfoEzmqRSURDSNWxDrPoYYPfj8Qg18mOH47Uyr+JZjDd9H8zZFsWURRp22fCDtCtf9rEAHi4A3hjYwglXtnBajvfu22Gyli3HC8isN5BCboJ3s5j5J7I3y+smCyzd87FwEn0ocqUfDx0Qjv9VOPWn6sgfyRk0xhxn0ReWFg88iWxum/VMRO2k/N3q+eWs8AUJ8eLWMgFsAV12LzzUpNgniW5Epp0DtzgMBByr4ujLvhz/nn5IT+w75hO4ooYC3O5b68tJ7a+ShY2rB8C7mLjDRyTGuhkhbhJBk/GWCd0cRQE/UCmb3WHFh+QPRf6WNIjUFGrLjIcNFShiwZBHUBPNPHL7zkbwushxniHvv+SV6T3+Or3HCjZMJCaPalaZr/x6H6lbfqnyHunBlli2iuGWSMd/Z/s1SwY0a1GgG4/j9hoEumH5iZ5xnRg1U3fK4HH/a10dYAktgKETxEoe+YTIDgcpSq7KahNWX4uE1SKS92sICyy5Do2nu20WxaAXcCxZMJZIyIKa3cEUpsVeBhKCOOEdylS6KpuDYhUtenu+yMSosjaM12bssgsV+VTF/mCwVnaKlVZNNJGPsTzaQk+y8ay4HOZLYGYNo7jSKDkqV5ZVEJy9O4ppj0+arYL7+1+I41SJ69v66j8avglnqdMmm6zprmwo41ZKhvgiH/0+V0Gcu6J4XLOF0AOdLhO1kXZjrmuU3436C+EmXlhwJLpcAKehD3yoUfwiVdsT4ouB+PgSrHGu77a02OZU8l61YXT9xTFZBGZDtnvLTMxc6RDJgXd95+7FJmSTnxqTyjIpnPFX/BGMju6V643xMNEueF6OHKa3O1ysHcY5PZ2zqNuRZ1mXtubvO661IGeIpcCjad+9pece5ynjBQ73fTpHkOeeSHaznooz19OlrTUYwgV1ns4eos1UNPjHW5ddri2QyLdeEggRvCKwHIW2ctw6OPpU2w3vT/AOVbisQCQy7s/LwXIzU6/wRrGHBYSi3tyvZj3a9c69jsQ39ROrXfC6kVLTr2Bp3zeqIO8V4ktIhC6Z7mzmejZ2wzTQQkeFdvbUu60p0ucHcEnqrLwIPWxy4zKc4UmhHfIhizvcEqKLHd4e6NpmJ3+y3xOqrAjq7KRyUm4Wypy8+DWQN044dO1AMmdCD0teDPBsXHMwfH25W7zU6LDmm/Lo91gTU83lJUDkIKQo8z8n/4eiK1cJ31H5EIkMy0D9uYXO1/9hLr7ava3NmC4Prp9f8T2/bB15IRC/Kcb92f4x9GZNwh7rbpzLNZHvZtLi4YwC/VYKEIQpPaUI8ACotJQeff0Fsb0LBCCGM+uL6o9Olm4fxcoFq0JSSwMXwyVnF7LHbxROpR9qcsnZeSusVi+S4SfZelQCYLPRmT41zoHbVzImueM1uYExMilrE0y7iEtQlSUeeFNPPmUaO18zQ90GsKfEMWxjZV/dJ4JfJhlP8g3lQdGaorKM//eOJ4eaXgmadNlqOFRNi5j68lCQfsoBNq75eO2IRdAMafIsbAF6dGJRYl1/nFx6DIAOfPAbVGn/ktQsTGw8qnkqngSTPJj4I/qPOYzVI6fQKmiC79ow8/HZ1/l9gvtg1hH12K9Sp1TwvOL4z+3VnuIsTQRMfh1wgTQeh8XXkKYr1WclyJRlOcH3Peg/O4uZbzido3Hr8FnTysIGPmovt1B9kVGTMIXl1iFCBQaVcPhPmFh9Vt67CFgQFB5G/r6ACvmJD49cwfitNlBMzJflJ8MYCxqNUzsWqjIkj803a6KNoE2ocnnj0f7z/2WzZTiYhILiSOYwOE8MjVnh7Z885+H+56gyDr6SXNIU58m6pPPT4serTRW85x+Bud9qwYEqQMtglOuacdv/HXholc4c9ZEMPJMHfRWxZyfHCz0ha+qP9vOdcJXG4NJMGmzBpkMCmiNiU/AXZ/o6tq8Vb3fgFQdcYDbxQNhUEIDP9sezMzxNQDUDHILHOnrsCj29UZs6MYtm8aQdTODgOMs2gLETNI9XfF5eVBtb+kNWUR/JEhzGgkJF9DQytqbQ2m2Cw46alMj4pG2S03EItQRbVUyKd5B92CqDYVH89aSFGIT8l6Z3valuL3MKDL8yGpvmCJAqZ0Bje27uh8wmzECCC2sUsB5a90S+1IHhIwzKoImNvSnrVnsHyA+5OvSnTv51YO9uU5FphsDFvn/SUvmL33IXu6MIgDSv/QbcJZ7GhZNd5WKWTw4PZ2UPGQ7anYgKGA+VIXySjqiO4a5VS3Uh54hvKGUkLi7/eMUVTM4TEl71c57hDNOktq3gv9EFyiPW22Bp0Ma9mxmEHMM+85TLv4ZwaLOM58aX1LDLLhRkfEI/9j35d4oGMDvPSQ2yjGo2PgvoetxG77OgaQwjUOAOScu+zGTlOsngWKxx9rI5bVo1IunsAVwIE0Mo3NTYmlIPI1HQhMMsp60ChDaVn3rMjHDCH8CkIaic/uYFoC9yv3CViPDedki0dUhIyQOF8il2GFxrD37GwI4feQmMFcTm4IQTeHhG4/9zW6Xk0M2kqByCt8lJabe6MvvMWr+FzgLw+4PqEM4T0bpR91Bkon2XhCm7WB8VYpENF9azUBopsP+amUzvbtYx3fX+Y8iEBPfaLVxM2A7zc2K3Tvxoca6A8dHjVW+7iNKtMtFaIYtITpKR0H8fQkpxKcLr4+/XCAWfO3kEZWWqeSjqcv/rJnR8BBl0VXJFwLf91yiuKdTMyrDpgowx8AmZJRiHrFsXehJhQFwkuwHrIqNCpaEs/vvCMo9IlB87DaJatxmOgytPUurFt7gKZdY82Xic03xw3taox6R64F2ys3t7zQ6KSlsBDCG6ynEsO+0lGFlQifxY8QiObdzJvL/lSAAmTNQxLrlAr9UDBA7WzMCXRDsLWTN2NvyjsjbquXA6h0owbbi3WW5GXGHbsFF1RPJ3Idecy1NeOCiZvZKQ5ywAvzl2nparuXlLB0FMzIMPT/g7+U8QK3HNYHu4BIpbivFMT6guz/8VrsS9CCBvbVCq3Iy/I9lhkeRoIOnuag9DxSx8aPKMFEPgPEQxfLzVSr0jsFhu/mVo0obeNguDTP8bgLDAso6gjv7GEWJDuWYe0GMNsrfbOS00UzG6xBkkAHnz+ZosFTEF94lg55BA2CidmKL5IIOAyyBj2OV/gEGSXh87rPFGva+tLnRnkoU+cjTeVRAcUI9yMLNdRrvR8t600IL7HQOzzm54sOh3fG7T5KJlyszQZstdaL5+S7ZTRBAInWz3gtgMAadKsY9j0Kx/g8SSJGBE5riSxjbrU3Hb8o69+JJGLhuVV9GTNR9nmzc6XC3UdADudMgcnPFyMSW5VanbphbQOg95uFmy4ir7p0/e9omRjjk1v5yPhsLEO7y+dE0ppblaxNzCsUp4cTRGU+/jNqDZGyBnz0ofxfr7/giCo61gYWa5y8OG3aaxJHE+j6TES7oxb2cDdMvgQAPZHOklbIXgf599jCWWhO+DPJVLrBFcJ1ME5fi56dQRhSQXtcx7UYSq1v0tXeA3P2WZESEGv1fKbvf+dzly051BNCYMtgi2aCRQVDgHNBlFGYCq9rsfRj5RhQ4TiCvxmYVOj1Z8+ZG2V/kV8luSVF0EUi3jjgRKB4VUfJjfcn0SQ5M8D4Oc8WGz9bOsdn0YVddRcYQFgQX6xDSimpfsQBcTNWRE5BrWb8ZNqv4B2KiVkc/dsu6RCRuCgedJaA0tUGsl0VqJ4mk+4Iaso7Wzb+d08u/M9+6ZjV8R7nlY+jkVnSlsV5WSmPbVe5+LeU3Yw6wudltYqx6r4qihUCTemBGp/5JL+dHhJfeuAUgeqq0IMqhM6bmgnD27n2xXhEOzDxrObdQjLKUKkdrPF2/hzMZ3UYeBO31UZbTnTAIb1zEfx2lX+//L+mmumZal6+SwJXIMg5a4JLySHL7dbNGtz3H6E0BbEFnWPIqqtY1Wh8z7+dNMm/r+3NjD+NkD9uzgxSy7AFGhXnHeGqUh0rr9wAZLW5eyClsfzIDf91d1IsrOLRmPOU+C9tMjEotJnGypO+Pl+U+Ar6ZoFg02/3C8Vt1+W0mvE/44g8bcGU7rVud+MJixoiDreLXYTEk5eq2ipm0juou07BA5baxD++wt/vXgOmKIOVDxN8t83whtQMLAIIcQsu0K/lWJxjqeAHIDM3mV/TPJv6t/5EV5S5+q0EBYPBh1J0r4bR7ZmsVZDI0k3n+JnsvqICUXnybYaSx52oajQdthqg5ExzZDaHxfli/b+T3p0cVDzyzJrNf1U/LC6bJQ6NgnI4bMqT2IQipTTBMKWb13XXljpnavKdHQIRzBxjaxqnmOdS3SnBSSP/Hu8uS/OTR4d1H9p8uwcbNSYm1iiqtvcVKmXFedU1Pym4kDqyGRMGlRX1QwhI3ZvDkMUHWEbzBsN3i+XFlzDBylQCv5jPCjHIfGyGnqah0dyIVOJIPdT2Gp6OuTioTTHKG+sbQFFHQvmTVEcN7sm3XtDIRmL6/H4iEEjnmBCXZ2trinxz7lSpzHb6b8bak2AWreEyNykOvnLXTd8gsV+QPdTQ5SKVsw4TiUn5kDYQ6fmQnUzCAWxp0GT0jfJAZZWKzl31wZxXooQeDjwdzvb2Gtijg9mvfZ+gAXJMZngROa5vBHyE+5CX5fciAovuth6lqH/sD/kInAjIAsZtq3Vw/OIrZZ6RPmgE1mKsvnNkBESYnjnfHEV4ht/ZDiqZxkmzI706c4ikSab48oR8Hrb6vFwq0M4/P6s3/TcsZYuS5+2l4nKnQG3MaYMZQjCUaMuI+iWZ4B2WF4CyINcwdV2LgLVI09YLY8n0ta71/jaAAoHByo7gUMfD0e/K6tPUQVvmFsknJ0gHBolfdq5OzVQRBbcXTj1Jp0hME6bIArFg6qJ/fwYOtt4wMFIEDaFf+J5yT/+ZeDhGoGf1TyyUj6xBv5BrYTnyGu3DJ1G/4bWYlWBEH7VjrY8sjeSbeRRr2wAt+N5ocw55Vh8HhEjU5YIMeWQ/tx9F7ic1OsJt0nIm5QREYEXXLghNuTwnshzmrMnuDJ+fURxVSH2TnbFpjgZAqc7F6dioqgFZzbRlaTgPbtWc1nFwrP+StYAq/m3eR4ZzWtqxl6n6LSKWai2uhTP/SXMPR9dPFLrlZfUr19S+yCIFP19nPRU1svuB4PqGXG805rjlxOVTxkYKvcxnkNu9vMthaDdX5+eolaCYxQQbJKlKyZWnm0p77cL+IF7tPGVe/UUgTF7zZe6DKHZ++EtAIUnjN8N9e5Mj9RjsdxF0779MW8tqv1nEt6oQXZLKjyHfRM6p95SddKxK8e49QVfC7lEUwvhIwRVnvEp1cataJjiT7ObMmXz7UYxXTDKZZDLjP2tgeSmFjY8YW2A7ncFRRy29F6PxhepGdEhXo9zr3NbnC91N0LN++YXvBhlUKOSYKyQIn6OwTUYjQxdRXibLA17qjfuvPGmDe4cwHtEZDaM2lyTmg2UaTcZV7UWFAvxG8z6FvgDYtl7lKfMgH58UAwxg78GBo5bHqs+L2Cq835jxInq4RaCmKob9OWicPT9LoP+3GWbxHWh24Ulwl11jwRZoEcY0nXlNt7gmy4SnBNRW0S32X5xNM/BMuDXleLt4sgyp6U+ACCm8gbG1aY4XYY/nS8+/KBxGdSo/WLdAY8lDTiZKAxJ/uLgZ8JNnk4wUKiHm//6mwYf1Fr2XRtMMhemq/S4ZprAjmpcsbhJOOIiZTXSUvHpqdtZNfpF3/mWI+LINqWq9rhtlyQW0/fDV27L7qB9mODrbqeNIrnsSRDT4YaKYHjpN0eQGerY6hHPbY0Ditny1qkK33f0y6ZNL7E9USLLH4UxQmEBCuXh2nO9dEGoZkdFCCaFUmyBTQH9Nl/EdquR/bY5N0gA5TWA0kEvE7Pgv9ON/3SKHbgDS3LT5tjKi7dU9prxj+H3onDt0pHJ5HYNSyciLiT9C+shoB+3uZmyNH8ttXc5hgDev2RAQUDAuWx2HNx69WTx5Wqy6cT9Ooa/H5rAtV/Nr0fYug6m+WPeEJt3AfyvyfPQ5aE2pFhA5+L0xTYZI117aqgohktTvB0AnIaiioqPZFM5lFSqbTf+4k6Tw1GJAd50u1+iHjOb4FcPUYwLOYopOZXnuD2NlsSxppc30tQHTc4tgGiFV2/XXNtSaM4BEHsXHeNdB4qV813HVCidHj6/iZOg+Pqrp0S4/dM8Itc/6R/lt5Oh/4em29cc2+BetExvmy2x2HwBSFAWxqzQ2YONiCHsqbJBnA0NgbAcMkvK95xipPqCW32vuaojFVzOSpDCj5BZueQAZ7PLMk4uMxfYJhHdAyEcvXpoKcq0L7bob4wMtrVyayfhWolbmi/xC9NV2sWfl5tECMJDvWO8JGlpRGvhBmiEWcEOoZh/ItLyx+l/NBA6w0eZ4AgV9tcXZmMXo1VT1enokK8LILS3jMsU+TUqGKxh9hRzmTS4h1srS3ff1Ya5IMn0OeSgRrEUiYwTJaET48XvKoLi1m4Y7fFiS+81Su3kTIgZpn+fLCdLFa0N43Xdd1SxvsP/WLZLclSg93Tu77ZwkRVodkSC88exSeMWf2b+fVE3DWw8EZYXGC6tsdOmaL8SwAxG/nvtw2ncs80jlXnKlfhHJtGTvEAF/t35Qi1nGl3ZEccxGBSB6wPoSvMFEMoKA2WxubOHA2O85T/GNQzCGw8Ba91X8BOARJukOFTTdy2/MDxOXi9OE1llyFekXP8Sd3F/cH2tIpIIrYLuNe9x7NxgTWa+adfQfdc/V2nYyZ6B4SxqFW8DT7v1306ELuVfaXYKpjtl4cbi7NBTfy3atXjC9D7BvBfLpw1qUwOImY0hOeY1zoLrxXrmhPokTe2yv7QvR+mdzysfGn3ooyGXJLMGIz5tAKLXkyBHMvbeMcfVxvbzzqdpa41hWKVLuFh8j8++hce4Vo55k8hZkEKH1x6/A+rnsEEabd7dWYaXGcfo2SdMHeDqESS73PjUS3XSXWBbCM0fXqera/s5SC2pP7INdF1eiH6MpD4Ft2KxylmkQr8mzud07bWFQVPpDXfeBgBkHgfhkiT5F9YgyYYFdWEX8fH8seajZR1/4cwfb/nuk54wkJDYYbEzC0oqYwqk5Iw0w3L3sVsDkztl0O9C6Qakv4xq0YNmnWOLfvaVlZYp/Jl6KCKSkOfQQFtIR6kHnUmLlyzFLENNKt8Um8TYmhJBLWyuSHj4rsH7wIdlS0d3X/SFHjpybgOwE8RqHcCr6WL1k5a5EsUQdAyKK2INW4GaA9K0fn6aQXnbJDHCTMHmnZHBLOt/FWON4E1lr/F2z8vM0DSODAH7rPjuo3cfET5qMDiXPxeY6ffz29AoKOsjUoqBlBYvxiMzFIt/mZEhELKNnVJPOGLCSnvaF6nN1hJHNu+fTl2+4q8XkO13ltRp0E557r4YOFdZMEAuEOQHUPyOxD9QQ/L1N4DiyJJUd3jeF1p4zv6NxVMaPf7akM0onYHc080kndqfGwTfMWfIAVXkPLVfCz1167Y7H3apSzX4unNu3AI7XyJVdp/Hd+ncjcnLvuc+EMpnEDb1xJtmYxpb2j4pIAYvzKzChJ3X9H4cTFPKAknQNl54en0XMyBBuAeOyqKestPI4xt25d8IL44FO5kHNl866oKP4P+jE4KbOyrBmQ9W8t3xmRRRdt5RAc1QjjZvxhOdBaiBun8+w/VUXyTP/h9a6e658qdqstdhFfB3ryDcoFtT77F1cFK+YQJ3cAdc6eDVeGkb1ABrnUOOovyTOYsq/ubSnXlSxO1MrMC4z/mqvd8YdvtN76pG2Dn3ZcMBMjDHjH2pQvFHZ/jRjDUaQHNKaXqPYWQ7p2dRHASD2SOPBAnPAUdgOjNkD0V2B0bCnh+d2krKhGAnJNf+oE8YS12gpqMboZ8Gbigp+LE5aCDtFUHb9aSpIgMOjLgT7QnS+kdCAjdGidkmIDZ0skU9z0RDKw0EOiPmYu2cxmsnVXSCajH5++NGWEa9SjfzJJajnecifACJLdHE6WKdb28gxAqIrHdUGpLGSBw/z8mMVpwvj6b6Im4kAbZanzxZ2oz40m2t8PRrJ+rb1nUoltGNO/obHi66hk5gCCrhSFoo3fB3KegScD60dXMFtKOOlLCLhYTZavwVPs3sLWG9Y38BuPkRi/IVR5Ka7pBIChZ+drgmNJwB3yNAl5/fcokLJGMLsLkmf6PcRoRiW2earSK8qrY0O706RPpKD1/YtUUZi/b9p0EF4YY26VUnRGrWw24CgILE2p+QHHJejf7dCojHli94r+bFUcq6Wo1jX4GzZ4MPiAgNLV8yDx0Rf4TritJ8aNm57VddVK31yFcLL5fRvGcODK2QVVYPCbPIRUINmHssckk2Pos7qBubIJrMHucOSzE2+ruzQl7H+Ptl7pNRXY2kqQ34610sUDQkH81Zl2YI6BHG6o3Hpc06acnCudt1ppTXLdra53SFqNmsr0JV5sOyQk/OZvIde21k+33VYzQa4pI+q+u7+2mjQJU/hMVV4q7yWr/ZA61J3yZGtou3vfcuQ1WhzfT1B6T2UO7djOo6arfG3Sb5mTC4x3qmruspIbb3jY73yy4KQ5zv2g6Hx0Svkx9Bzi4dEELk8sAenbGZIsDD+FRvXfs5apC/12zqGiSRt4+k9fF7MgyrZLhtS+lqehswwPsLY98jPqaekuryoHhm1It8NQUz4DzgSsZjP6mOtcoctP+780NeOKsH90DTod3WsXRRJ9BEY4j7npcXaUAuBad6gDyjYU1wgMqn4uBUbTDWypxXe3sXbyKtu3osiRIpJM39pX2iNY5rSs01Qq2ibz20fD2wybsPRMjrnXyZn2CGhw5t39RcFrtfI1KMtXH2Zp0nXSl+xAHeSxFYo140nEzFtZtFV+iR4THFypVTGycACKNlD5sgFPRC9s3/aA2DGgM088BgLRHuExwEuD/dL9bLaoh2tr5MvfTYzCQMhlMgeATiKSBN6zgr6xKj0Ktuzhoz6J2TyyKS/Kn8PC7PZBX9Vr97lZi26GapNhydP1W5X060lLWh/hyDIu0eklFDqGZTqkTHpkKOoblV7aqAuYwN3LoulkvPb5PK3pfSOGirUh/2JgkRMnYmm3+eXQe5ED3oa9F2egEFibg1223tRcbNbIm3iHGGVrRuZAix06hDtBglVAfkERaKb19wPF6ZPiWP7j7aahNe4oR0KCfVvdzLgb+LDCLdAwGJfPfkOkSkFehevL0ywhZ21es2L6Cvfsgb33xeqHZAb0oS6pC2DSNMDdcx3apIH5GyYkTY35UGqP2BanPd7l1beYaal1Xh7yE8AsdgyPVW7piopGAjNOq4ca444aMbJhGfvoctI84+e9/TxmHtaikWooUzdHDzAw2C4GWvDBfHXU6NT0QFB5rlOSL6kjEiF29lj53UUPRcYddzynsao7SNdhdEn5d6Vy4NdQg3dlchuz5wtf5hId67a2X7yvpIWpESGMkVPUt/0R9c5X5kZhclvq0IWMAH2eCX5PzMYdiC+cILRr2nWDcD1EAjH/dxciHLlnADcyEGz+XywL0DlCSk06XoF3jFB1YFwTsAJKUxpabZnS2H7d31liQ6ei66PdRDGRIQIySMkF26izExzYFhPkrNS37ZsNcFIC7uc82Cp2OATo5lhyXuv3NJkbiMpbCdevIme4qybyxsFZUzsl+I67s4qINOu5hrBXINYegeoZ4ykdbSA7IhgEjeSP2gRGolObeCD9l7LptzSDB8wmg8TMMfM7LUyKYw2xWa2/+Md9dindQ6ulA+qPxkZiFIJ72ZovLG30PgnTRrdFPjG396fM/MSvt42qtE/rA3XmlWR4Ik7Tv4ei1i3SxIaMqy3UQI418+3xb9HBwb+/jk9Uida0rqajueeEs2V7Rhjtr0cX2PPLYJ/WksWKcJaGQQCDfZetSCvthA4OLEPx9rqkJ0ADeZTgbBNb3G8ZtGzAlMBvQm58YjxjgIUOJbT+jBef6Jy5cSDUfL0QeosjX1kwgPm9AWRnHVaQ5dGpIg873W52zW5ha1UYBIcqGEcl8sb8nUoSREFsCBOPATxvs2fJvL+TYmqIf8yy9OM14xnh4bMN06fm5ETlee+wcTEADvmkmWim0OkaZeTueCQ1b4H8mnJxZaLFYI3gRFrn578Ol3CupbyYw+j9oYYfojqs2xxC0mf0OjFRWf9k5lKK1JgIUCnPEbj7l6nt5DbHQ5/pT5yFcK2FI0n9+TvCUM4ajxOGk9qDTXyx2E0MfIgBPf+wBJQzwypcKq2e5Q+4z86lRCMu5lw9+cCRXETTNHTE0iHyhqnFhpVunv3Qyb8Gd8oV4eb39E9GOBlifK7fHQf+3aAXMS0bzRxrk5tkgMMnJM3C53KChFWGG/X7B3ucFHAUJ7GLDQaxPCGEXyd56OMVVdkRJ/NO9Kzf+Rr+8zSDhNbvuJcdb6TndBdvZL/T6V4MmJANa2zBpzVW+lg8iZOXdTaVoKonbg5eHZjhgTsHGihJw9qqZCWeT+HsNohHXxV28oSmVlbElYzOJCIgH9vXeZFfgBwq0MyRc7RWZUgn9AXxgEFgBGCZCPf4sRHKXGVLvF2kBL94ldXBrmB1cOP6bkrlKqZhCjEAVo4fQ9PYCLfcIrZxkJ5nh8XvJ3C986DXDrA2OQ3OBYNGju1LUiggDb9Ia+M+drMif6Gu3fsmXZf5cqH36oonWV4enL5zmooqlZsP4XCk6MhZGmyZBTemitWSAD67jYGlwcpjUO7XZBD8138xyZpIFDBYY3oYHC13IqO6indYk2cMR9xg/nJNceFlahAXwcJb0V7rfuA0b+rhYRfKx/jnEoEXMfmc4nOROc9VUi/fBlkzv1ja3fNpJznwfH3TchNzOd4DUo098uQRrFEW43JKooELrkAOkev1EPdxlcHuusfUp7K7+ki7afn1ltN5MaMOC+M2WrJ2dlkYjawLRa7lojViqzMwqpGhz+22kAiGgLLX10ujRQiQTdoYQJ6tqVuOMWoU3nhMDTpglwxPtOG9hnWqy23Mtp7Okyy3+CtspFrUq0yFrxwD4a5vUthIHUYT43AjnkGQcDTxeK7pEjDbA0Isp0w6G7U9UelCBMHsrmfXdBLpxbBAAusZgiuqQNDe4j9uy4bY45WLwPW7+TjCQtdf1aROJzrV5DLVqtxDv7Xxvq5EtHhAoAGN1MO3aQm8nEWTPfTjaW2Jycrzh+4E+7a1ZeDgvmX+yNwhWH90TLTNgAqpgX+i9+HKspWVd0Pd/jf5aFHAWHFo0ikUF9VLCxogi+TzgJUoWFUC1QPuj2TLWB/cdIDrBLuOumQv9PAJpSSbPZSvjkaVgXq98cT/nS9DJNRKzGiG8abSJlTkEkG0E47BF/G4k2KiROrm9pQQGi0AkJWOhDWsOpI2dQ5XRL4VZHYE1Dh24BUeeU+B2OabTPyYACzJ3dIKB4nrShUdxvD+yUbEGomqsWAFG97MtJS0jixNjMdQS650GeAJR8ViDSeS4lXW96jQiUN+zWlooBlzabXADGhIkZRc63Uoz0ukFqLI5au5/r07Cel/tQ4Y7/0efW4QH5ISMp/JzGKV09EKwbHsnmaY4oVyUJ/BdH1ZferNzGN++YJSA5hZ6FLjW8AJAbI1SdwBO/sf4iw5YPdGl+LETbIIqnKog2D0XprUPpZ7JuzZEXsZCcbKrFFQIOybORNbz2x2b+0ieuyC+/m0Fgz1vBvKjLHNHWr0Thmb+lHX2+gaKmFfzj9MAFl1ZzosyB+rBxiUy7hPP7DWoczYOGSFVcPJwnU94zJ5htizn4UG4zqaw0Biag0IzUbv4IrHPhrKg+4EvVBTVJQJyFJ+fSANxO1GPTEwtmDCHjBxY2iEl517vUn5ly691RUqTvSYyudV3HpXzmqJyOI5kwhBmOZBh7YQw3bt8mZyafSzya1lSA5mo6VN2n4APqOz9KQzZSszdRgBYohKMBT34SiD/JOeSoNhgFExtQKLA0BqfZRGqQMaJNHTTGh0Avkjcbr3QwsaSnlkUPA/juPuVmEUg12zvhWvY0Y3RGQ4YkZkVmYi2wOjjYECe7hrxe6o+6BePwdHGnKmlbMjF6hVAlLEGRNNJju0SELj4de4gLQ0vg8zxPwXNSoKeJP1YAHddD9wTOJ67zFyRQN4XkFeAyKqpZAGLI2aZAIgWLnWTuBH5FdXEaNDPwJEfq1rrY9PsN2JWs7sDm+DW8SxeERLCT0wlD6/kkhinCKHBjAEKvUqMuqsYNH2b4lgeWypClAyzZ47L3LOXHa3no+E9uF4tdGFXSP5PLKCgOuW6mq5eTpDWC1F2xLX3AQrZ9JQdKyP/iTxo7hHttENfhiK0rd+D3zhy4P13Wym3cp1Ap9rlC8h8gVVIbtk9f+pqxChP3KoHOran/lQb0w66PmSXNqr2Hfo0qPwKwpNX6LD4kG3WapTCkkAX2WMZC+uJw6k8ZlfBqgKHo3NSQS82wfGFXBDaGeG/E57B998Jlh+vTsm9is15oP4lTDq4Hzho7Ac6DUCxl0E7JzzyJKcnqd4FbZKlXunS+kkpgAKezQoqkbUKX6I5WHJCR4vh/c0KwZNThUsZVxWzgtn9tEGa9pLe3yB3CA21BSL2K36HEFTV9fpFF7ML58+thUtSRLhP2DGE0uHjNFuEKtHCbcoCsxeUwfgL/TIzPJejbXw3OTzAbSTrdlY6AhaVwSgMO7a9yeHgF2TYsSNoraISd6OQ8ASwOaVIeRcB8VY5N+cIBG6HajxCyZR8YTFdrFWGXymz7bfluYGiauji71GDcnEgJ++qAyweVPC54u+pPEVC3RM8CNRMLaPHLUOi36CbGsBSWrTy64dLGcTXRxlZdg/kQwJ5deFQpfmDRRvx/MScDza63t+dJT+Mm7pwRhOiwePz4HFP5p2wvJoG6WfK6XkkoqZ1qTDvYQv8bL5jo4FulIp5fF+I/k/JcZaAgL7QJCfL6al/zTYhYyK1+E4n3OC0+N2zyMn6nI3L4E0+NegArPlxnFe5JpAzP+6f3p8mct/wxcK4S/q9R8bQe0K9RxYYLCfr6DMVdRTn69SVD5vcROCTchitOhQds2Ybn1BQKBMHIf1W7WxKKpi6z1QvWuyyENxitumrdmvkDGO7Bjs3iX8iaUSNmV6UMGbCRVayC1kIWOlXBDM38lt8TQlVj8kw99ZUM6irbavqHZGLS9TEqwvBVIlNpN5Z7c6Ll2K7HLXlsSUmpJPp0LOCz/qozzd1pqf0R+TeuAW/OBGqXiaasbI1OP5Hcc4r6M6gvfC8NCUEM7W4bdLDAQa3lsryRccECBiTTrUHXZzbv+eLYRiI8XIxjvYXJ4CjgVZDSkDg6uwXEpqq1zBtj5eKD4NkfZJ+oR9+nc6CclysxVy9AYePwjcbi9P7DE17/oMUqiHKHplprWOkyHwoaq7FbKtlgD0pxQksgzDv1TkBXODLUm4388yyhppgwNbviQBa2kEYebFUrIZjcCWKhBY06EvNIHO8QiavFIcecCk8wYH6QGrPELIiKvAJqVyXT2/3ijxllJ7Kw2yLww6l+pJm06LVY2XKTqMmMDln+FcbHD//7RqwAkCVXG3cDKSHBF1HU5D1OFsMzWjuo5ZVZnTWRQJVYcoPPubx5pIGcNBaCR/c//zuD7FhStXeQOuHtGPNtXub8gJqIiqj2W34E/GvosK11Pxr6qijV7S63mVn9v8WXZ2/qIx1lm3DwA/KTY9iGb9y8bLOxrmiGZ9OWNgFTMqjXkpN+JpOuKDPCK25w3pqH95sh4/ffRlMtCFq1LdGMX4nbWSKMfYKK+hnTNga1I08e08IOkXkr2nBDF0ZHD9JA2YmTbzgWh9O4sg2/l4lqfE78AlspxjyAl4bsho1lKoVkgbNVOrskYXXSa8yXep4yWmxIAKPqgBnit12OQDmp0q3PH19EO3mvqmvei8136QhWSgT751u/HbMIl2C6eQRPYQmscAAuPXjddoGUz0Jxc/9gDm0uKNop0VxW9K/tuVrY+X1bE6rJaxjko7wUQ7LBf4tKe72oQuZpU2TUnBDT1iWjeImxaZ77QxvMqra7EqwY8tlWcndqIWoCtaR7SN7RIW+toSLurZ7kwLjV3MLKddwjElitDbvR1nUI3Jiu5Nna9a+ovM6m5aVTa3KqEgwFGX4SzitCQpkNrxim86NJJ6iap5wtCo8ZCMIOcsMiEu3PDVDk9PU3dXtVB314kzVL8lQnnST29nYt3F14xSLVWgRqQJSxcONaHO1v95CMeEy1JyGqmhi2dDVrw54a1dSVdxjJx1wAUS5km7NKnfPFraxdONiysxiNFedXpofAeNZahriWbJgK5LTft9kW05kfpe5xDqOqtqFLsJTnFP0rmI1jgWFYB7ggggahRLGLIZVmpNigPiyg2HxFy3bYh6sOK6BCN/RnK3tiSCzRd1B56WbCAgF1olmDizzqK2M8UpjDytzADGmjkca//iLnDuYoQxnrbVZwqZDfREjykpyfOo1MOk3Ye0tLkkTB97ZnA6B6I2iWFJuwrqxr0qV0NFYfPgXAlwitNzVHL0LQzxxlGbDqEMeb2vqzYSjrK4fa4LhA/sXSqvKiAgIVxaXaswXVuFWBX51V29bKcJLbPosmcm7Nwee+kQmzy6/Aez8u7XFyQtunJCs/W9jRq4e8sDryMArT4JfDqzb/ZF+bQEOg4AajsOzzBVE6JfQJVSg2iIWHszxiNBCUL8fbvWEgczGIIHQzEyfWzBTdNMtiTlsbu8vT4icOjOTctkhgrhMpbi1mZ7mwSFwtkpl9zZZZ8T50n0hWBsfY3vI6LGhOJJcZ1plEdFDjeByrfS3robrkAs+Uik+EQxFQzLHkBZV7icDED1QqJSnukWPLR/+Y1tLxLgz2vKS2ScUychMKyCcBYHSm2d2qq5YPq4/kyuMSeRv8pfRfQYJ9bE7DyxBE9SELRT6woFTKs/BrCq7hcIWwAsbTbXla1TsA201qe1CIvgzkXA7mbYMO65m4HvylZqHRIeMCeuLGU4zj2/PSIDjOZ8/LKxu3gyIqlXwcBnC/DlDBqC9C0sZcMc8qVTtihb6362QxOOgaEK+MkwFj/1PllV2eTxcrMr5ZGvcNF2K+HYoEO/SLafCtfMXaqpzSF2G2DCMYuJY8eWcK5eIjNz9SfhQIKiBfjn9ZUbiW5/GWkvHqj+4df9fAfhi3MoWsDoFSe9RAMii7fvKj9+bQuQd9BZFPYWx50dq4STsX8xpp0YZK6k5C25bx3P9Ci++/dg4Hm9WvzByKSGEmfQiZoEiEHElDwWMJct9sAsLVsnQaQ5Im7JMgdrIr1JUbeAw/lJo7lagcVwHvv9NGnGAf8Nyg43dOerp6OqoF4SCfNYYyE945TLo+t0Qkw5vkKm6Hx0anF7plat0JNH6QSYWRKmNtHA++TBbK7EKHyZ37NVJxX6j0CZd5QDzKAvOJlWJ4IGYr0zXMKrlvcDdP8wB3WnMsUK1mqelkDizeYVsiTco0sIKLc4zWxZuOkiREyYW7qIvdUGQj8kRhmZUJ7Qa/J3OhFP3Ao+bEjBvEXmEafup1f6aWsb2f00swpqkj84AgvCppCuNchefEz8uyQ75ITOpkXqFKIMUDep4AXOolxUQdUeBPSxhKHzQ+d++i/P/Z9hAXvDz6dnLrsKbmj7x207l64zCXP6cSdSU7Vif9Y6/eqi0aIFSOUVJNcLsU/nGE0KJcs5v8p10pz2h6/+fX371J5aomcHvcSniS5/dm8KjFkALZsLL41R8IRBLlQUIZ4cerX0bwY1FNG75b5R6GKgyt0c6knOk9CKBeXRm0kQrjuHl8Cko6tt1EuVORT3FITNvIfyF6ytxpBIMzyYXwJOb2GnlMDLjx671VHLl2GW86nvrGhPdXNWGkrltTDYO/mnpsX3NYBv3f/FzaRCIMr3nm/g5caX+jRuMBRR+aGEkCRUcLY2sAx7PQypuG8jDsYuR6y8dx48LMkBUP4tXxjNYrrFhG9yucociaMPRxcT2Fn1/0H2+IAAd5vW/RKKmQ7qY/6HYpatTPB9Gqbx9hMZiEilZjJLl2swVL3AUSNPUZKEf91fA1vT4szpP+mCKUHE2Qw4klag8FrwXkfkcTO3l8T09Z78z63sjadZcHWk6T8A5mDELfZgIJH8ka8e1x386QUBIYjprPsOhODBfWq3MrkO6np4KweCDZNn6tDYbigKgVOFskqSiIlUB3KllMqjlkjbfrSfkmfWp+32v7fMwvkG525bBppkwyEravSTJ9aGltklt0sRmG231LbUSAVcJVdqlrnzsO6Oar7NmkwGnA+N5RNDrPhUhIZpVdZeJgcBajuMUvaBLPbtCg4WKqrRqc+ayOsFrQuktPOfhXOUN/+PrIWMaNQe24peTV7U+9CGbBzlMdoa3PGnbco++WRrFvk7M56YCE7Rw8yIwkGx5fjhKlu6iDdFNCfXvrb2nPwUROlz+0c2y6rcEfa6CrarUpFhY5vr0cZybHmKMFQc/oxf7SJFYQcpj5sUUrfG3MvPIbGzlfyphOA1bNXBHfyM126Ytzd2pGwVXM06QK9DafvlaKOCYZ4R1sivLB8HZ56sgsEE3bmYqeGoXKcI0ma500Gc3Z93qteuFlmfSx5udf9UwrO0HzO+ko9wK7ZgE4K14SXl8iwNiKvtTUpKmOFrlUIzii1nBHhR46sghdgjfLJCm5LCZ9P+gfBoisjKxrTShBtV/ocOUzcV+SERDbIPcnag0dy+IfolkSkq75MtQ9tU/ZvLQwddPoYR/yGCY+h4Q9QuQYRqHPtvySMZQrPMfQ9oFt79L1X7VbjJX8RSgMjQnZ5h5d+7DhjX1dxpDNUngPaZ7+47UtooU4PJFvBotlV2mhnSIRz0FF/IjJKysF2Q0GmP/NsjSaBRRqPk28k/vTJ0YQOc3qamxlxeW/Q6XMJsagnm9Ni3ce6nf3CVlA3BRqvAn5P9lCG6qFTWfeqRrJ1Y2+DCe7YuW9ZV52vDibjq4542szRITwzrWcLKERIo4soynQeXTiD8r5dxiIaDWXCCG1xy045wJfHwJ6m2s/xSMsNtZIgAiHdXXDxgQhSCHr/0rdGWU8heCpbbMmK4niGYx86JjKp/CH4ErB/xloI6QR/zA9uc+wXCDdwcIPKeXYCtEuPimUg97KHdlT1mT8KnOKyyiEtmhdlfCcpB0PX0WZCsD3R1phuf+X7C+tU6YufbsmvXVwcpZeYhfsvt742YlsWqtBsZQAW/TClnCyUm+J9x0oGfM2FCBs15YWthucq9EB1dvLdWpDD81M3W4BfEKZgqk0Biu28AsYDOFAQknOnvRNlQTl/ePKJCFLmdyqfQN2NlO6dtrj2PljzhnETL0t19cm/RTkDRohxb7M/4Ayp+EXzGgoPmPcfq++KuDqRvpRL/AyoIrFHVMx54cwWx7YXWTlQmoFr3HzNJFfk4/j7iduJ1kxZo6i1XT5MG27YKUHr62lQC0DOPSquWM2bPXDotHUs8+luZojAmgAuOTkBMdg4neDBbU3Jf2IVZ1EzvVkQU8Ta2YIrnl31GoXYp8F0UClANRzqMApV3KBHZKfl0huozi/iddmVunwwnzg4ojFFgNEDrasI71BwQzHwiZx9P0/jojiVfGuQCLaxm31BenB0J82wOfYDnVQvkpbu379bLWTzG3qjGhBkiLueWu7SqCg2Vemes/SjnHLaqhVqFpzHun+bU8e320+M0NxcguyFLyjjYmLSUsg1uH3xo2xajMGaw/y7PJhkNNGRcAGalof14NhBi/gajJo+SWaZFW2ypnd7oDmnkzhEwYXQVj0GF0UjZBECAZgZdW+dnt/4Q4bkh6d5gyGP+vCDq9HrrDdelHu/9XfP9YfXktHziT9Tk2Td0RG5unXNfhEac0IyyBuRjMYj+ZS1pFWhG3WjT9/wvo8a8iGZAWLIYjYGf+bb+wOHeFNlH7s2zLwi0ekysfb3MFmkcDBermEmc/XikCfeHWay9f11JBfTHLUaGQuuTPey/zK/gGaUULjAsgyqjwYb4UebHYO5r1xK25A0YjsDdcfoxWYUwKCTi+2HTkjrS1jJYATiXldw5QWTEPcsn7mG24HxRcrWerEP62HnuDvBzkYMWSkDE3BMj7tViybXzQ0pU7J5uZEUyAmPNXAB9lhv9oYzheMMZNQyHCAg0PFoK8iQSO/ojkTTzI3bLKzSjaGuc6SiFltu+BqA9dSVuDDHmyxrQ11KjmStiMWUgO0RAVxqaNuTlNuanvMxrVqYzdGXtrWQLu5NisWCk18RbFwxG1WLynxApXV3goM7S+I/JFoAXZTWfRpw9oU0uvBffQbmzBzvv+Pkxac/f6AAGvzHtOhvfXqyPDcQYxEzHDu7Xw039eLhiZhzfUxjUoncWO6NUwXJNZk1p6llB9sh3GEU9AoPnqBwTRJfhSTS94XHjnJL1vJqbeJHN5R3ZfKOfPnl/w9H+HfLa9ONn1iP9x954C1bPH1f/KByJKnJu3dvjPwYBTvr87utuMvHFxLEr6oVlaSRtY/fz9oM6ZldHZOkgOm35RxNNZg/CdEU2aoCCalEbUq0Q76KMA4hrDkACOqS5LMzUanLKpoZetwLPgALh0Q7d/db1WH3JgQGd8ZLTyt8TPzXYqll5m8460dxwnq1XaEfoL91pedBi9PABZb+rrtjUINXKlU3+4bH1vbCPeorElvn7Z9BzfOjlKKx45fIz19x51itSGK09GYAPY+8ElCO1QMcAS0YYTSEy+HEaj3q8xPMyX54Gw+2wC0HAOlFIi0uyDVSDn+RM+iOjKZPUOW2bWE2SWBLR2PUzw+/HIP2qp9/vXCsSeq1gxG+0ba/D85GIanGuBgHSPgkmyvSuR3H7MF65O8/fadokcROfVOQi/eRRm3FSVDS7PnWUZBCqTNEQgPuKi8nmDlwr/sHpMDIxtAIYhKsWtJwk/3+PId6oeayody8bxia8KAV18VYtc/QcAerJ9667wSexkviIR1QULAVZBLX7MZFWkW8Fx7JJ2QgcMXkg06l7INxKE5zBTjLz2pmjOQx4CnYMW5hzTmipcw688YsNPm6Ikei/lYMULjzlsJPTf9Q3jKo7Cf4XvsJh2+NqymrwIp9namujg4L+4rsEGlf3oRF7sELghzo4CEbbH0jaQHURvBn9ycG704e2nWamTT0SnR1ox/1igDvKWmdRVvPMsdsQuKLGtXnnXGk18k+3otc8c/F5NON4z+IgkYsZ8EsUCVWYrJpOkcU5nqAwdlSu5helTewEIRO+0+qVcOshCuIN8IVuWe3PRIqXRoANaeci3DEnGAVDwV1WOFaRDh5BPpvgBZkOkYb41jTCNHeSSXcnTTM6Il6sx5x8O9So1zq0rt8+xjLEQyH+7Ywy9YChXc4gOvwEFkawENd0LJEX9hXq4Bb5GZYjURJJJ7yxKN+SrJC6LuXHJxYDxMI0s5jjCXmLUnI4NMKT4IzLv+2CbjIxeO2KltMDq5e/fxUVK6qw5QIbObnxqo1FsLdgZrUASHrw0wXpvUqCS7zIrfBtRoeEh731nZ3IMpR7v7wUmEqwGFoCIyVwgKdxwZQ7m060ZXWF3j7LlKQ0TrhpnKramtbGq70NVpTDZeOxpYTCcZ7c0J2t24+BVMovCMYWr5TCiA9qenIuJGyzTCqzM23PN6ji0g8Oxfc4yg2wkCe2VWaQ0UJfNWU43JJOkhEd37HIem4MOvgDJADOMvjSynysPy72AjjvzTA9o+n6SnOAdliQ2e2RbDWXosab4x0ZwbRcseFyX5g5Q5RQNqb8vt7YA0beRKUJXAtbWSBu5B4/44SaFB12zX9hK4rzncV94oc0p8cyWdIH9KQdT0PsVl14qjOlfQReeUMd7JRVtw3CJO3PJDn9vheIsi5LR/20e3Q36OmdStLiMzH3tzyBnol23UrC0fr4cEtw3yY5q0euG2lPVoeTpobnYmJ7kcUE/6Qur5/MMwlkKH0cG0/aRf47mkWi6lM6U3cZrSoAtBNH8J0QeM+r/WEbm6J9R+CG1+HNKCn1xHPl9av3uwlP03UDqHdDzPJyyEDGPd2bW5WCzxh2L1EsZdkbruAwRzDGOhm78svsSjSIB6w8c7pYvCENQpi9Fip6P3YKNxIovj1y6+VqE+XlU1VBa99vEgjXZ4/16awsx9Y+10MLcRk+Bn0CI499ULzwi/kNZXMu4r4QrUUyIH91F3jJeiBSmnNRrqa0MLGDEUBnLQmBZeWUZAOVc27mq5JrBlXerZU+RUFOW9Va6G9a5qm1mt9cVcvwzqWQ6HToOEGPgwM85KDcGvQlzYRR1tJSzugAiAt20LIBiChk7+6yCYeyNrND5Q71LqYqA+2iIIzhgMV3tkKdweLkCyOedBQ919e6X+uicUolxEeBDa6swz8HohRVSrKSO9ci1xucRPALo87ZUURf1R+kyfEHEyD7pPHE6kyrTufFaBcOtT0JOf5fdRvfuxSdDZwDR/w44cGRuv4PKgv/B5Pw8w38HJY4zpqbF3k3glENVrJ7ma66kUWirV+NLgr9sbOe1CJbEJonwvGqsn4B2+1Kpj7dF42mc6L7qFni7lyiirI1w+jkWZHolQDbwm+3+kV6VgZVg19FVwyV6Hm7r7yeG8cDJxf1FuYk9EVwRv+LXDtEniuvFuXOrYGeIuJwB0VZy1NsQv6kN50XHmVXNDsoCrvlZnquRWhtHm0oVKOMhcF5OlVa9IjJBTmJAYsbcyoAMqsi9jWZBTAfMQ7jZ511NHcmVfE/qne+35B2IJgg9yvhZ0jWvcM+Ev6+w3rXmYthBQNo8qUOTjLr4t+J5lJIPjPgxoqtIW4AGL60y40/BFBEO7bli2fKccKSAE9bLkr4rRiSqCb1GgPujgqc/cqtS2y98qqZtkUL0YMwdpw73qGGDvi9ErP6aWrb2iR5jARTEMKhkYq0GT5V3twHlmtsejsOFiAAl5uFu6zNk87snbZtegQkls56v4FO1Ir90CCmDZdtm2bNZlFCn2d9UKw5bEIfRzri4bEvc2Y0WuZNJGtdrtER0t6aw6l4URqUSSgA9vev7qk2FEffbDLuNUbbBlnZn+39zMvE7TtS7yuW38YL3h0u3/rB088MbJNgcdJsvX04LihGSjXb8vhjzZP7YsxvHLP51Ii9Ev1was/uCLLMx317xB7abfNHuqk7RqfQnyrqodaXjQm4QRq4UXnwcpz2faVolOnhqiDSafXptjPBqEPAOW3gfJm2aoRjJXJwjnhkzN8Sransufe1NEykTTQdP7HAdw6+i6iWeJGwJCrE7OJSN5D6ViQ2xGreLbMAnK8AgOcobddbQa7VoPvsmaaAzy3woPnJQjhp2BhkNy5Hqr/zPG0U6SdF+P7aXQxNyTJRfBG05q0nKiCyEipGkVoZc6P90YQnOU0x1YwM+urOBg8Wn+HWulqPjebIw6lMEH1JiuVdTn3XRC8aqEIlqyMeoZgFV5zWMwIVPkRRcqtw11JP3ZBsRp5w9OripJTi3wgYo1S+DFa8z7FyfBeFxwAjcJRXalaehPK+vzWBpZmuSUgMWO5UV0J6qV+3qgzQKvHB18LZtpow5+rJxPdxFrEz8hG04J1x8wdbx1mzVIKzfjy0pkNxBeUdMWVlGOE3A2LesjJxLUu4gvH2aNHcycZO1696/DzhSRWEJMs/ypvmGZEN8p84VBSmikUXHpp9kTOqCyIMqmK9k07H8rCQfdPawTRj1s4ajMjN1nD7Rk/peQKDCToXK0xwz2fLsUZpbM///lh5i60D9C3I7cpC770hFvGTVeHy1AeNxt3V6egNor8yiFdlvhnMl/xWQbs3nJ8R9XH3ZnaMZgLh/pkT/094t2LD9TLEExD1VhSuLVqh1f6NMxy8vyUJyNwckhwhUcdgbKQ5Af2l5wD5lN+j59mFynkRdZrnSTnIiU4eTe6+LkeaGcYEw3ZyLGxFr0C/DhozeeoGUYJyJEXZz9+iTgmzrdn4HV5LnN4KqO0zR3yo8u5v6RmPxYqzAN+pktIq8IqFWPTDRrPb8q1aUba3//LYu9TDme+ImZNrlTSLLGjtBmlLP693HWk9aAJe+1GmllikAw9s8D2c6yQDZQhdvj7MY3HH/Q0Zro1JG2Hw3twMF6fyUAT8XKkqqkNkcXnWa5rX8OcH1WYT4pFiYKwSCt+QP4FfPdbkqf9IB1KmOqu3xnl6SnU0KgCM+r1AWC4/CJy21tl1w8H65Bbv66xfJxECqSKkMoxEqCwcY5E4gqOPNkgIFh7AeqdxmbgeSTMsoHGgBh0CKxxgWdw4IL5fYptqzjLnjILQ6sJjqLyeqpQIJaVDPy8P3M2piwq2aFtJz2RS8cDd04Mr7MWfLYhll8FuCV/t0Wiz6tZiAfQYWhYSpBw5M8uPMVIaP0V0lwklL8JIMvZQc5ZVlo1RPMdsNhL5fNL5lbztaATIyOw9zi+A0/WVnBb/UUVPYiwkZihnRICmeh/oH4X2uIxdOHSXLQTqmbRDVnClmdRyXVOPNgRrE13+YmXQejmb5njywJM2BFa3BWR8+x1oNVxeXEGewxsPgpfqSqBf6ydCEswoun1z4rgwjW1w1s3r8goTDjF60quy0xXThk4dYiyCsVPujuBohobs0u8Pd16ApdlKtFP/WA+VnYQGMpX/d5ndMcL7rH1OPjyLhcki/3sSKIAYZeFY9CgE0TTyT99C4y1qMUUff1unWQdyy/Azb0bYMBM8sjxmQ3SeKPuttiwnPWiG83bvOr84/SE3QZsek4lU911z3hulla760BbeKTnHr+wB7y+8BaZ7rsjDQpT8dJ7v3ZOml/+vCPS58I63W0KnnJdkkigPPbw6wdIQj62mEt2+9PD71bcWyw1XBwMLCYx2hlHqDyUMkKs65Z7MFQIXaoAMEeKD7gkE1rHLA6ATDqXWrcOp0+/mBttI/Ye4+eeFMPwkL5PINJ6Vvh8ZKG7R9h8/QnR3LCs/pEEubgdmVprOLYaqMB+LxxlmYsb/8hl/XDiScOO7iBUyBv9HSntAc7DesoBMgEVtrY9yx3Lz8+A/G8hcOJJv+Wx9emnWPsRkh7HtNCdxyWqYdw+6mykh4JjpNTvfxeqORHdBltkSK6PaMNGgmKZGNxVTBVBnaDLC50IDzpopLPgJyhJ1chR71zs8f07bvdnF/oEAnmw5WB6JDC6DHEd0T04/8EeiL0vPDIOUSSX6P6aTraQAOvsHFz61qNHNz4bZZkcmWd1dKADrZIJELhJFM4uUon54B9mr5a0ASKDb2usg9YBQJ7ul77UXyRSNrjTVLQLwU48J6WUAnWS03w7GkPY/YNrAycxdN6pV0Ui2mwdwz7zKkNMUckPmyRRjWy7sxgi/zqe7EjO0sfyR2q6e8hD/wQt2zKfRoN5BZm+odAdtjaK1aFQtTM5V9Jfit86bqQYpOhrXnKACARbHOZfv1qS93vk5W7tz7N8JumbnCyfSP9mKa/clObQdslUzZZOgKjmuT7sY2SYGO7ZLZqNIoJ19dGyh/almhlK0pHS5CdyGAjVPVvqbiDC1r5Tb3cO0PiWaULmksY+Ax3jc1pCnJUNPzcDe3VYBhIqILvkFYOi5IqcwGrCETqYwP4PaFvUJlfeAI5WkiyLG2LkswFaEuYtQvp6QmJfdtccqcV2k8USom/17ESXChgVk1Fv6Ei+xTaByKyTKClLMEhBulNlN70aG/CRLQEMfdOz36vEd+ZNcKtOgajheT89d23eG1E8prkQ1UhWf2VAUoMNp/Ez/TdtxLsI5eFXaWZA5suWcSu3oPrlrl0BWKoHJjGiz1k6T+RBSfWKAs/B7X7f5TfE8rpL7CQy2TJVx4m+NN0y4UvThLsFzfquXL6AVdu0IPhLFjbgWYGWL24MavsoT+17r8vq4a3P6zrQhv80WzMpYjaES9Pdj2zwIyledwA20PrhUDFqZ6MGFUZy+kBDFxwQ8533XcbU0lZ1JQlNyTHeis03LZ4RxwL0tBJF+oVz9APiPzO8ms3rgUTGQsmZ1a4xBrpjSsUuM3lW5Ntg7zsWbWA4SYYM/fspt5zxVbBoR0M7vim0HxsQHi1QgARtzqIZDVMsqBHrAGBohBq2fOVSKbscJso8LW4l/tnOR4f4R/m/pPJmsDppISvMLZK8Eoii+pJCJwvFhNZV85+k6pcoPnNAw/w0km5oCRlR5QCKuSOU+7yMY00w31V9UgK2aE82x7gkARMv8Et27oBt8naz5kGus/w0eH7TZ5ebx9QlG8fb68V9z//ovOgTJcwbLev00nWQ8rgGl1pHbMLBIqh2UuvlZyXPbhhqAxIRIISv3h9Z2KruhV7VE4QXf6cC/Ff3N8KDtR46XznmhsPSShV4UhI2cuz4EQhIhaQo/DcuWwT87jKvmVJn+r0MEPUqC4k0wUFmHIS3KR4zKbMvmEgBuY42mRDzcF6lA/nSNukSLoQHQyiltSloyE/v/1BwDGvR/81YUDza3a6atlHyrtFJqlpq2dBdnJQnfFALbBOnifOMiaK86qkgK7SsgNwN4LVsl7dIRrJkSopTq3Y0tEZ6odxQ5zKQ307WPoGCC+B4mdEJldgZYaM6ESWR4TzW9YWs+5Mn7tgjUzDPcVC1kt85kdWfbKJ8mAe8OwGjkxkdIWA9bq+v0f2KwMjOQ9oo544uTmu0EOFZPnkzI46pd37LwE84DPScJt0JZQ1w/kHDgAr15xjc8NaZN4JBYjlrLpLGUWt0LLmJvptIORGnNaE7heTc48T4Gi3EgyCTyupv3mNNeeCOy31fUss316hTGefDRzsFReFFUMK25WecOCW+MbiTOFAYN6cykjWg2j1P0Rmm28HlGlO+3yzO5Z584lOpB4z6yEu3DdEthKoVLK60V90JNZ8y7HGF6EcE4753hg5a7oySKXsV5RQhjfFNYkiQFbxtDUHbDhdx9N/TtqIvzDcu0YJDt1KDKXd9Yqp/zOepTUY8aNFvr97jIDnBan7s+leBpPelzKYdeBAA8MRouUQ5DZDpYIr7yygCL59u3OLIWIr2SFXNgV55Kx1BETdHXOg1Ov1gYo2x/iNAP3K9lqSKuNxNYV51hRkHoSqT9xRRzRPsqAfcjOy+b+oto5uVrZsGekrl55FLvEwiKMyOaw2GZgxBe7wSJ1ZQy68zW+kY0iZf1bihD61T30moxLDcZ8DR8reVDMPpP5tAFKab+TK4fX6vnqwYqPUdy3A3Z5qcjul85jwFbNlmKG8rbb6piJWN40pdoINHepaF3p6m/UxSnF9pZ62D+J7YMA93OlS/vhKSM/4aT9wkrhk+vziveSzNGLg0ZoYnVOYQG3dy4Qffon5gXQmJjI0z/u8eFt4ie+WPr6a3V1Khbp+DA1JjIo7BwHvMZqlm/jt+2656qCb37PTBh5IbslUPFBXw+qk/Rx0kP8s20R9mHmxNsTpfHzcXLChpu0CyxX6F28TuahWPnLjSn+vh0xloe5aaHNuSKZ01nGW/gkOOo95TCj1twW3PLYs8JJ4Vygke85k+llYBXD3S0VhAyX2oTaHBIPzVnPqFEZ98HJ0GfciHKoM6Z74q5SJI9LX2wnZ16RTu7Kz7fBN7oMxhTR/oYoNPVPoOe8fThzTKA2o8SLk2GTBj5ZlOuth3l2GyYGYIuP3q+UodncJo7Qdsi5n0vi5SRwh1T3W3KMvEUDRNas5M1nsCpVPo3bbIACrzt0MB59c+zRT9xLzrmPlTuMr8+EQfsDZAp8EkWEdo49CGg4tXLhsmLmruDmHRCC14rwm4zGd8JacwEAlR+5Xq1DAglfqcu/CIeT6JWUhcyied9yH2UTHT7TICet5cpjP2shpPV3ipaTu/CIxixl6WKQj/JHDRYACZeCSc/O0ADrVdkfKLNWLsoKAypazHa+5cIK9fFBBo3rZgq53jWU06PtDSx5UodzVAvTCKGbci7yswbQ+bg8SMXyMURevHds9QTrlVJubAvcjYSgbHk9cpBBa7e6152TjK/A3DnJ+dLzLe8afn+F3lnazAgQAcLL4yL0qS3VAvXvADRemx8NSO4aHDMKR6JzduNgwYM7SbvRrdd3rPMEJANR78KdyaaTg9n6Man7tdCx7+QiN69/jYTK8v+4aUu/khVxfZuad1otdbwkOZU581ocHWeLATrdiXxCYD6hxXI0bBbn3FaT7rLyML5DMp5gsIYiRlPBuyRjnsnI6sRxCf/uz2U6VM6qFOIkMMkzMrzjK9DvVvsVDpz6SU4fi/HTzI7SGhJTkqNPv2PFG2czREqttVSCYfWeS3zwkb5ZkriZGGc3BNseZKlpR4/Ss2UlqQwLjYNzOYMui6j8bTy/NLaWKNzNKiZsvv4dZeltbqYM6KOiOt0DO3nzR/VD125vwc6U5Cuq8jprHt5enh8efur9NY68F4+1TsyMdODG6Iofj2BKG/5pYK768v6MH9amvatI37JDEW8ASYd4GOGHatdwQ0msMdy+fGMAzLPoPOmHw7cUkGld8MEmvTuIOEp0qpWAnksA7I09sJQLa/UhQzFCaPtjzHgyyO02bJCPaskF5FbWEc5zxZc2/VSkt2wIrB9zcrZ5EcPXnQu5mPUOwiWz/tYm2EFBKuLwTmV1zrrhsq17Afuf4q62z+YyHDlP5nr6/XUmQUV16SbECgTtOTRXFU6mNOTGM3oV4krYZBI/B5AJjCl3i1SZuJp+DnUnpFvi69sw7l8IKGsmdCFcrz5EOT3vx8xZ4QSmkIsLqtbFoViQY2CNXcR7FVZEzTauOEWPhwfQ5iba91QXoN0zw5thB/nohAXdREy6pkW/AHh8nHQ0LuzYb+BrskVOc47i7ESzjAHJq9BxTXvqwlC1VJ+V+J9bttDwkeLbU2uVmMP+2QXPlS88oROAPTgyNkHfPC0nx+OsTs7ZS5zLDPP52/r5jutNXaaqCqhWAaCjXQHv/IM3SyN/BW0dubqxhHLLso8D2eDKHFuKzwDENGXIViZe4B5gQ3gQEUYy82QJYDhgkMU4bZFwO+I+7QFmoM4W5jJmJLchO6z00cDGm3kDPoA/BfPvkaRkLcMC7/BhDHRkh68OcO36Xe5PqoqqhCMWiG2zoOClb9fx7Mqu8I/CQGmwqwHVcQU9h4kXUEiBnk28rA1zFQq8svPnoCMIz3nyH5fgD6njaZYGNA+yWyw5atPuPhOMPo6fmhRixmtFgsragNg6akPB0kykfEAX0huISHnXWTsZKu3jETZdh7npiTYCojANR/FN77PJCsJISbg9o+6sPmX+kPuogE8UBdrJI+SUNrAfsnKZV6Qdkmp77hHQcQ0obodvVqBLDrM+i4dg6cY3CN2bI4cd96Cj9OZIcExK932XVgXXQ1DiY5JVF2sFC09yIeiB1L9xLiLsJkEwxzCRGX9cWM05vZ75L+F1QFP25x5a540DpDyb7Keytu0jCPC+qjPue8Jvxo/HjnbHuYTOtKkRXd6mkE54Fifmyj9LVV3SrsPbKrvZm/qQ8XrlVOwF9kOED43Ujf1hWBATWx5hEK87JeVMKUk7JONZLlGFB2ssoW7mIW83qc91pngO1pc9psZsdvZ5zgnfxrG4Ywg6xACg1yqVZxM8G6+UjDQRjpS2L+Kkz/LlrJTKaXrpq2T3jSbEayj9HxSdoAxpPAz6VSfjYps9emiVZNMdeZIG+HWdacmy8Tsqf+molSj2f5JjfaR4x+H69Zx5tGV9qaFEVdqgEathxvOKOOcsIqG9zdeq3xQoPuiEHKnFaKvMuBPEhpRRnu8CLZtSYk6bNaCYeRHr9CfM/gAPZ2L97bZ1N/JZJQLdOsVaPo5Eij9omZZugP2br3jlJMEOR3jU1GJKkufbQldDZti2tfqjNV8O6ECBgT0ILGwV/R/nxpay62I1e74A4/fFXYsh5nh8FQjF27WXXOU/0flFtI4td4laJEXj2f5sJM8XxcKAbOfyImpVDfbt0Yzv48BtoaPeXHGFUID1nSZu2otAZGmbH78Y49unEpPn7RxMX6Wb4Jvbk4EPkoAwZdOZgT25CeBWvF5PNEIcdAIjDx21+DGhYtDMWhvIx13RnB24liujOo9qzeopmE/KIGpUiafrybdnWyH7s/DNEegybfRIly+C1rQbQzXkJ5tat2vQznqUSpt+ITq58BgONawUay5mqFE/JK8KJFuKsz5+UirMCV3mbblruvAEUVLBaS7plEU+jYPWxRoh/ewwVkH+RUsBvZB28JRj2T4o37Vy4hsTLcqDJ+pKoAl5ZkT8aVz8AmNxoEOEpckLErDZKMiDB4TU0WQUon6Y1d8qnn6AgMx65Xfl3WnnWYr7QC6MsIx8uTR8APfTOd2Yzbipjf8lWfJutdT97gwLKXkNRcAILqitMJ/CfIYA2u+rlr6LMS2y6icz4emEKPL8FJCf+99ATP6/McmEYnZzlB6kbexMuQcx1mUUNm6NESXC9vUcUdx0QlM+k2KLvbte91y28AI94hK1C0OJ0WNiBgiYC4izT+Cyy8HEUpGCbfK7220/zgZKQ7HzTczH/Tl1i8ZLx/zDjdI/5x/5Kc01QgTtXPSjKZsELys3mX2j4GerQQZv2oMMQ43fVVWMF2FaaXKqeSo44T1ouZGK/8Pdhb9pJHHRRWrbPEEfvfhoF4uDYY9YXkoi3RExQXSryVSi9UHreJ8uObBineEqTVK1Uxzmjhe/yBbLy60HIuW+0XuPUIMVQN7RrLJMBs0P14HkPGi9psJDHYNXK2LYIsDGfBo78+mWJNllyaj0ckkJquPYkenJiFEfOkUZRfbAGTO+rHFdc2nNvPvxjyMe9GHbZeRbiOIAUJ+TkwuJsgsYOTFSZV2SF2hXCeqksa2SfUkxvNRo10GVn53ikRnIyqP9uEMvpu/48b9A2VOcMs+hOTDVD8xo+AwprjEj6bXmYi9IXOi0N4vLiVNVlHWRMsvI1wmf3QmKwrZMjnrwuZOn7q+t+9crICavsEgeX4hZ324vMTVluJQelc/z3nP+1Qi5VgqPp9lGhrn51Acumvjrsv7nLOlVaV5uuCnvULJxUqDM7sA2KtyscXnLokzSqkk2adozQy3y5V2lrPSxegLv4q5Wl3cVmvL6GrOqWLAv0Bd0Vau+B2Gqr6Rbc9qrkqMfg29ixGQuXRxTELtayuXQtoLH+/KcE29eJCFfzyqAZRX0lRNOPgQJse/NTUuu4Eg4nSuXQMIvvpWF0Ce4RmnQQZsAKqM2JSPD3xcWAC+i9roIVaotxrYlyoH3DLgIirvCeB00bf0yqSKqdi9++nsuYF4jJgyelBBo8sDFqV2XJ+8PnQ3y9IJ5NWBIZEVQRqaAV0WBnhYXNzNUFwHSbTdd+gcPsuz0baya+vQe/2fVFndm6DjveuiRYcvEu1rxE2mSPOL04Fj/qxyYRTLQUCrxcCksqy8cMGsVFy68Uac9LbhINiywzXljh6ljSXAQeRK2y88Pu4l2fy3B9YffHdYXXCwYLIUFJ3ilG217jXiNsM+CPPTp2Ki8LYxsJXYxC6E00syatyuEWwRcM8LcZ54zfOZeC2D9MvyJ8nDAz3r14tNX2pG2e38aFR65CUXAdaxI9J/wMWOj0Ki9zr5LhIvB50einpZ08/D81JoIx4BLBwo8NtR55o30LMfKupFDbB8rb7DtvHAizPLuFZxvk1XDMV4YlyqWfWqRSUUbQOkiGYDH7Y09x0IDCoLOQeqCz8Bsk9nbzTxY4nhFhx02K+P0GqXaDpXP5kJRisHMkGCyMmRaWlpkx1RND+IS8X0kwlYBg9e2jWiMPdsRpF7Tr4ZV2cxioR7zmeBvgGhhPcz6IkWqAeJweY9/u/1Xk91s/AVK35dcO8Og0asvS6awE7EVR8KdxNzlKIEX0zZL1Jn/WCEhice9/bk0vGKUoQhR+zmz8A73Ra3jSi4olTYa2KF/JfGyJ6Sb+kbBMi1AdiicY0tJUHe4TchGRUsgioU+q+/2n2yRpz4uRc7KG+rggbNwcPdeVTYkvQnqPUY4OzMvpO16c2k8ThqI+Y5sVuwQI4OA3AYTDrB/rqcR5yBJ0cckZDHMP4y4gxGRUzJ2TjUhQ5SqOFA1HpHPNQedzJ4ktigH3nZLQXzQhniWY2AdDZ0kEjPcoHWMr17MJyvkqx1TC5bQf73m4vYKkW2OX0Vf0xVEsIj3fcCD+2bvIWEdlnJODKs0YilhzId7DxyuANPVFRhMMZKdcGOTnyCR3XfEYkFhzv5C5mia5LFQCWJwuoMpC4gKIe2IxsSNpLvr8BHtpSqahV2TMK93w6qR95jDWwJWBz2JB5UNtS3AP0jOpBNRBDCEAFMn1R+owRyhpUCpxNV08s3eJSYiVhTm5CocSoPSwXx5BeBfPf6NXGk729UXEWEsDzW4qfSeI4awvq0c9ASJYPfO5ySIPc/lLdZy2ImVmaFSiJyXIZeuGcz0W1HAjv3bcO33iI7Kt2uRjmskKt8Ut6WmxcxNUSQJGoNTNc/xyC7NBfyYD4wYwd7Gng8Q6U/Zc9uj2ki29PCHinyq6TSRujxtToJ8oaIAQ9Lyg62dT+R5RBZHdVNQKyC6IdGT2sWMgFpQIDJx7oR4c3X1VTHCVsjmvdJzYzchZCF1Wlj00HL0w3kmw5p7fYr2Qq/zVvlFQwZv8kGhxopR9SgKlIkNoXF+OoDj9jPQK9JxS58pKux1/hNuZV+9bsOPVUPapzcNUJ99gNH4XSr4E9yCFGereFX/lBPNBl1VFP9D6anbvvpFbFNKZlvW4DdAIrU18O3ojFeZJ0POrNSK4ASVFclTzNicO0D8HPHYIu/YVWjQO5dAdWvkMxXJNEd273mVgg0saZlCDk6/ZtMWdRxWJc76hGY6lw6mGM3Tve0Eb+8AfUfGe1Pw+LvS0BQOUDvuM8ZIA/Us8Xj4aqP57yja+mwVarYkLt0p7ro0ubGLyxzTYekRIsFdj1+dxvrogO2QuqEiYkbf3jIhn3GIVGNeWyynAftqKdM8o6wju2oZdM0TJPJpYdmcxd2yfB8NlAHLyMibnXnh/vk8PpmA8GWVld7g2+kIl+OeXUITLVpPpojGo//Omsoti8z9dL+FBqhiwAro91Lb91D0AaVb4g3D0RiN5AKOgDdvHS4trEvKzpfRyscyxz7PhnMKJDo25wn+7x7mrHHrnby2uLaRal7lyXIOOKF0R31oZ4CeG/5/37ZarQpX//hAJfaWvNQv4LQOnO3vPBcYtSmB7TwfDEJJBqrP5f6wR34/G1Ldo896IRIfgmaaXib1lfyqCyLIT+pw0e2KV5nffP/BOstCAi5CVSDxMnwA4pSnTgrXXiNoxd3mv4j02r3IzRov1jplvTY1orTuUyxugAwgui0Atm+hZCrm0cjJ1wTjSjtwPp8kfxwFqAJvCy6dnat9RYrrmrQcfaFOQ6UBrRLd8YH9DFT0sLad32ExAiuNJNJH4xBB63zIqmxXvuEYHu31igbIPTpGWDYI/8jJAZ6UM9yEPSGnuP3CkSGegKj3ghVtZnI9+YSowoO+r2k1wwVjC7qSyKhAELLqhpCXzFpPomeL4DQYM+gpBUdP9pjWO/ss1JrEFWkmnFRxjY5G5GqpACaD2k3AK3OlHoRV8dtnmqZLgiatCzlDRZHmZdxNPYP2UVTubw4cdFO4Lt6ITjrrfPwwaMyguaOSGJhvhVPtekUxbHwXQKyZKPffw032k340I87OnfWvAgiVHVcM30FJaz4JsUzzWTKtXmn62XN60SDwPtlaJgRPlcbCVP+PqOU9aHoVUC8OX3bSipjDy/pFgkooaF3GodPaa0jH2g6g2NwFd+C3sDGIwHjr/sfX/7tBHjcuwl8pGx5g0Iay9B0TDCAM6BcpldiaJ7dcjUDJ6js2mAoASjqChuC1VKeylMMIKcIVEvp1v4R90eVpL4Bz8O9vVz62sNIf9egqD0Y3W6AFeDglZXGa2eWtwPPoAHjuaBkhOWj7bTjMbxqY8eWArP9oV7PU+J/L90WK+ci+rzksuJaGHFCsXc9BcnS0VJA4vI+qQ5svJXQH9WXSZ4zlXqE+Qjkl5IcUn9t6FvG8yWygCO2iuoOWJLYkWSAWn6YtzdviBaJ4dPZPAaB82SDVERFKj0MNP+qeaZ+3tqKYVSlEFEud70CfSiOx1oIFoD8AB/4ZdBG1L1PFBWFxu+WrBIdEl7NvEJ6lyZ9t3ZbE7BEG+2gvMxsisNZv7x9/74JnwHHPIYVI3gZTlv81/DHxgKJ2UNIMLVsKYL/oAgW3MF6HAvMujd6g0Fqy/wydQYrHPICx1eL0wCqePTtU0qXUJCv08MnyRCOwyjenjLxOfTgo1Ks6J9bscFGuTP0tbUn6TgFqEpSaKA9594jOuDnGwJE6skVtAkZP2la2WMCKdrsUjzCCJe5dE0HAYJAIvHkOQkpdWOki4wCye+wiakXyEajeLJXvYSZe1unJGhL7HzvOif7J4jtxCinxF8G6+r80sKAb4fo35nKII2ras+BfwWq296crR7GvONi1Z/N55mGjtSjcSa95Y0MHi63TAGOpGJkTbuE4oncQa386lVce11WQ2/wovDEMPqwDM1azmp5GSShOQywYkZPVNg6cQpD/L5ex9bIlWCNdz2MjjwN2n+emAjMOqt7hFs3zyORdGvQVvGSeNvv0LTiTY+/jV93w6ch1agmKJdgWRplss/ZhuynsRm0WhGPG9RgD47VZ1AfnPV6qLU2F/gAfvcdLC7uZZO5sVoJRDfRSWEiBCAfzk+qIl7g1/bPiky1AV2VtplrfC94btIVH8OapWxgEfrvSBXWu5BXtrjckbh40zvuwvmUgaiTRPnLZdqzLNqrXKAGa1bpoYkHEzDmpBea3A6qIE6sc5eZarCIOM1dWHQtX/62vItX3jjNTLKBxT4sK4d0XlmHQdOF0IkWyK/73ZXGEcm6gfCewQHFO/hxD8pbmIPuc86SMJXEuoTbzXtVrj1LQa2ZLLrv2rFujLK0RU23PVgQsf+ODBIvpny/3TIiKNlDJa7QG8yQqiiMVI/hOL2sH07bfOXlvQOLzsgcGKQH4Aj//qnNeQE8VfZFvNwiQZDC/nr9s4h0FCvdn/eEdW7zKTUG6wbfBSH7ZoYi47K69LFeqHbU5jHd3qt6lscXcP4E0rVev2VnH51ZZ/0nfuBe3OlDzFlz8wVKUB3LINlaWeJfkX14DPGJP4O1OrwQe4HAFZDj1kZ80hEOu8sYQI5MarZrOTY65KWO2u4F/IOeOJBW5kd9bT4uhwodHZx/zeXmuMVNj8lmNm4wMwVqmcYRi0x+jQeS1F0q3Njqk892a1KZW4RnL+jXapAFGyFBFWzmK5oKDVX8jO+87JotS0r7jTBpeCWBFfcsXaEuOC+cYRZgHgTyG2lWWiuMh/Nf9VefMS4K0oR7NzRGrDib5Axqnv4sIYlvq+PppBa5SwwoYDRgVRKiTvQC4eGTKaZVYAq/Td26rn17/gt9TWkRfHvmBxRMqsNwa73RCUp3SscYN/YP1BrSBm66miU1ay30zwQP0qSP7kkkQxQSw1xHaGoKjclqpbFofM1H96AKwNVbheJAQQnMcqMcw1SCEsG2WpQ/FKvvjUlO/pxgG7ahPP21wPKCXvaEHO68bz8TpCgImI0AJfu0xgAv6UTicmVQrDt+N3Lu5ebLxdIg526gT+qBX4lYHcvNrZuz5zHVBu3LVpHm2q3m7I492GA8z5qhQtUzamSlL2jUBpl97wgH0CV9lOWFwH9a8zbPVpXVku2uVYMVd2iSGZ2KNDowvIcqksQsvY1uioz0ZSRf52xbBYo81JzWwSCuJ+8DmPwnirRmMsotm/CgtuN38TA44su78fPh7749at0nHKBv1hfvfob8MkaA8CYQF8CIw6I3HxUPGKZCajsGJXr7hQMqWr/Bo42CedCC6lc5fMfutTfP2+vjbKcZBeQZ3znKSfv8tGqgQOdtRz/JGoxmT712vdZmRV7zdEPUcizxnEyCi/YEpqxmndy6xQkNUDmevUotP3SedJA99mDQ/wubZNIySZR8sSw59ECLqyEeNvbXFKlAhaoggWcMDJIQ/3Izmp8xJv/YHZGwZHSHCPIpn8b4A2C5JPSoLF30ZskLb9PxWmN5BZyADWWwwDr3ZPRM5Owipo5IPCvbdY9xtoDWA/biQPfywgteigTHDzImz3Xau8Q8dgfbm0OpLCB/YUJwCLf67z/DpJ8PKe7IPnQKHGl5ZsPxtDPYKjtOzCyRu7YroepSIWcxL8wdnb6HyYihPBh0A/qUro70AhOnlPQtyAtWuwTybZXpz7Fa0IZ4hHNNAAog71lZ9beivQ9OfjT7MoNLVyyOc/kTqRJDKYYgJ/rx4I/FYdGuLhcN27y0kR2jubuDNB5XivJNkQ5sKfNAlpZPpx/fvBm3FowB038lMeNi0oCkVx9Saj88Q+Lehjm54P/ZDIuU9hkdtJhVjtht7DaF38KnF8nnzUY6VGOsP3ATX3Fgrk0IQUyPrYykt40qVS49Goht2x9rqmA2ODPm8ecrLkGh3SkVeVLECkNy5dNYZPvnbOTbILedV0i9dV136IX8S1auxPKrXgC7CyIsyUHD1od9UIrLg+M/1ElA1mb9aOFzRYC4a2BoqI6X2LWWM5c0BQnSNtj6Oy6LXZRHhk+i8GVSfSNlWOT1HGs43c+9s3zDA+ga4evPJOyeb7eW0EE2/8zA2QmbwkxkC3dvFXj8wOg3dMcVQJewRaJwg5ONnVVmnned18FDwwC9xMwoue+fvhrmvMRozigsSO9oB+ZS6/gbcNEEz7lZGFIH7UcMxWZ7lmeew+JqKolicdDZXFreGCeD22nzNjgmd+ybVSanBQiEx8mqnM/EBm2QnISB89Pwh8012QmG52fFx9e7Bt6rOCnos13pEfSgWJSUh4JSuO9GdW/EeY1HrHKTjM6u+DZB3xPSJG/uVFl8aEZ94KnwqdaXq4dvcBwdwLvLW/r+b5qIvm0C08t9EVQlZC/9NanCxjSUAvlvvoro2CemQQLjhbGcuhAxBbubyJ8V6lXh6rAVrQnxoBPNGtYBDhu0oUrtqbmjZN76yHHnS3Ka59/AunM/UiZvOEFEEOEEBcVnHQqOLTCs3i7XzDd1dogtz0pfKlkHrhG06cd50gcgn31mZ3dwQTBv13f4rXgETQQVFFWbKG/O/3r15jjc66WwMi7A+Dn7UvHVvkZciXz1pKnEMJgmOVHeChuEWcXasFtqNEvzAOV9CKc0oXu5V8t6yFjrbgg6lY7dQbwSUypv3Zc1FLtyYeWCaoAQGXTdZfKWa/GJ09iyycJFwL0iQqauqWosK6y1ktKIOtBrCamzWMMv1m8WFZgNm9yYLgt7uFdeUpVCLDloPeWEUvERzAtwewhzD0UOHCLxrwM7sZaD7EuRqUqKK+1nWQsxERJcS13+9wCcgQFi+yyoWcmOQdYu83EIWvFZCJ2MLzr26i6EgDxH+NkqHii81VQs6obMOI/+UBFMLd3YP7lU8sQGs0BX1EcOj7S8EeAldya+oYw+0r2k6QLfDT+BmoTB6YYswOuolLs2HVYaXIvV8ViDqEeeEVUwuOCFCi/CzOVuOq8wMAnfoICwMFAIV6uN+2Cqe0iC8q+NLdSynj+TgezziKSoCfRg4UEilQDkC9juBztnRDbvMGPlORvqGb+5GIWTIMujwth5JEDO30TB3YtC8M6BzJO/ZA8PX60ewo0tpGEdgs2ybnDFESNp46tiiRMdmXuwP2OVaxuYeYwDjeA447G85aOGz4XDvTnpKNvN03nltqzOlNma/oBcUeuRNH9X7/g5fQeieXszwCtqHWllbdTD18ezYxsaGiLJtpFzPU7wJmGseCXgdBJy9bYdvGyosSH154TOzczyvd3uBdk6RTMc8PkEvLVzSzdEcc92UT3fh5rRXFdQtORnatUEJCbL65RTUwyhMBKQurHL9EzrUHxBveJKnKHx3hnn6ru4Gk/uggEq8W+P+s+/wJtGco5UNpC/guu+HVjJJJMPs9mHk8L3Ert9ewmQPgvTaUi12gps4Plf9MwfbnGkfKtDGtMfkKHQ1LAdIOshZT6uqkHDEelhpyYf4lFoFFUkbB8mX9N9J6OcoMc/W5xknoFsDWQqDdOGsEMN0InOqr/Pr1cRa644wNV95u6ozqhNDGfdKwoAS5kiCqSxhAvj1nxCuKWOnXUTqUrLu4gSlXz5GBMgS7zXJpuFex8vbJVtEUBKEYSzJShhrdfW3NGzxPY7YYdRJwDonkhRoBmduSYVbFs4PFBAlzdDeeoapY1vG6d4d9zErqS6pUGMZ4BSx+KSsC0YmwGXsulpkTqTQerPNGHbaBd9XtFOKv7amRi9Mi2QqpKc4UPBb1l1HmxpoodWVtCH/GW72zEl4Id3jLxeFYSkWRYPiYDHf0x2qsH8NTOgd1/il005/KIHu13mIRh2ViBh3c2gkC437CR3HTl+Z65fwFRvW1VEr1tDUOTXLLRRxOx70w9jZwXS9YBRerZFTutaqWyrE8LrJmiFMU5xUYRfgxOla+CKWYn8W4dZtViONA6afNO6FrH979fTSqJb12LL+TB96vax2xAo5u2IDCWemvp6CrlFF1oBeQoEFYQ/+Vm45uCGsQL5/ALgzXdIbMIBKHPMGJ6m4BRknJPteYn1N4lkeBHtmMHIiogPoMq40YOnzQkF+TJjj2O6y/0hCYpqa3gV+inWxulUKSvxn7FPYrhtJhtxw0tS56fXQoIzUuawIsCDuxScooMBIGdbsN0uAHWIb9F53NPJ77bHvXHpBvCfBzkUwJv9BKZTBvo0YTaZGhSPeeKOpSx9ZQCdNGBkdu0dLxjWFcL/gxMkrdn3COC7aU9vFyV31WPVDcJLlEXqxnEWJoTP03Tf82lWOaRkAhDv9YFVggznU7RsFslIP2j5PYO+czyxvZOSzUJmeBMVQbDEVUcgpi3FvuGFE4sw/+toQwOhlxHwGXsTGyq8QjUDrZXAtpbocRB10yrlDo/CYFV1RfyUMf/XgXgk+mg9/KfIfHopL/exhsrOwfrd302YW4FoOU8mgZu+S/RGrJrFdGewSnPRSvu9Xo8UqOOmZIP6bOcwmKbMcV1ZqhcTTWvFTSdKHky4fOiKyR4oBHp0wiaQz4lCL08DPgxUdo+vPf5UaM9n0o1+pw2xs7k6a9T4uDvYHrSO5ptHBvB1Lf0PyHsiFoz2q97exc17IeLsyn7Sxqn3OMhDa4qrVDcgBgFV7GomogPeUEHbvKsN/KHZY8A4Byils/djFvAvJDwC2xROkCpyuTJVZuPxff78MOSWOQqkiEo6tKr8e2hOJYsSfvZVWSf49JEroEIpBptlkOQHvuYxqnk6/kpCxuQ/7+dqF383FNb4h6E5XHNdOEpGiN3UR8TtponQAkVM/Qh4e0YGuPj5nrqGyPZmfq/v1kBFaS3kU8Nh5o2AKcTis5gD8SUvxbAjge2ULfylUu71IB3JYefTvCRchjXLp7mlSB6CbbilkDT79lny0/xnB/aAoGZsKi3AyL0PA9wzLqWokh+JtY4gg+9lRjUQm9puIzKkM2x8Tvs0GOCNyhnZjZ8RpTB9E/WeZZVs67QVcZrzpfy17AAm4SxGGqy0zzZSpp9emHmTs+w7TW+K9owlA2QYhr4cfsfLMEmeKfuhQcy/2f2scc0CSbGBzaK99qjNKmVyK/HZUCof/cIcbSunZmhmmb+VraSCAM1MqpEZ37HlcdaAVTnu9BKZDfzO1/zN8kScS0dA+bZC9M5EIK/sCmGZ/yRNkeqqCXEKAVfp7POKRbjJJL07br1wh1TT+OWK3ZKF4By1z/enJuYEc3oI8SaQW9U8dYk5Iob+niFOVdw8nE7Lant7LxF8M4huZANrMDSl7DaC1X2hqjN7QXHM1giKL8CHCeixt45it0UFlg9vR9L54FgB3+MWWc7ngQpQsS6hsmSA80lJFt4IBH0no+RdMlayircx5eQAzgVwtNjIcp4xS2SCRoNh+++IkOiSfwVxCskn0xaukGqruy2sc+Qf2LNd8Goz3fqFVf5PbW0CTAxbZOIf9R0FIgZHGwYvhEIykt9VkH6oX0+i6oE+mQXe7us0b3tdhD9hnesEFOt2mg5wdiVP0vm9GaaoELCVNfgKc8rgU2S9V0rUuAMlXKDIAl4OXiBj/WBhWdWWxZoDjtWi1DQ2Mz76BV57pxDFc/HyIuL6UiMNliSIrWKKuxZI70qAAr1wZjKggHGlH0QK47F/Lyz2e21fUqQ4kyadowgkhywpBLylavOzT5d4n3hWZSc/WbTT02oKHJMBVWf0lBwWI06XJ43VZIme1bgXiHaJ/fUwB32GlTID24GCudjT9esYnKHWMHF64fkhRALKjEPHNshE/RqM4Rxns0GMtjJ1ixxpGy8ME0nb09Ir9gmk+/TRWXuXknrZY8JtpCM29jlmav9Jm4tzthKwxdwruLs+C8m3Az68ezaJFau/nABwhulk8KQs2RSoHSiB+UtErsgkTSW5mnxZ+4uc1Gn8cdqmuDnhCAU3iBXmmfNw550b1KQEcuiyzEiZzc2gOn+mbiUmbq5pBp2cbaL1kb5edU7mVvwu4SXD0sB5L0wmzkeauXa+5URWTBp4H/aO9FkcgO8vfjJthBiOQLDcFHhP7v9kqZs2sXPDzsHweufwC/dDqEIXZIG33XiPtp01Vsi9EcmAebuxlM6+Pj+jYtYuU82sAxsd03XvfOjntAx7GRMdJXL6mDzFh3zosOE92viytqjqwsVtcJ1P+5dSV9IyKGHWls3TWA4H2uO0Bd+Mv5rwW9zKiYqw/kMIcKZf2pvzwtCwYi5DhYjQyGPeCycooO5CHCCTpqUvSDrC84A1z1pJ25wIzzTVsSigCH0TfxLNgZ5qopzh853oUBBNt25cZlNSvVsNd4NOe9GhgpJbrCVFky0SxnLYX08ehDjZC45LXFnu1TVmMcM71C2nEe7jj3vfI/V1UDuKa7Ro9iD1nvKpPD0Y+vnc5fdFEb3M7mylkZxJ1WYaYcbULIlkqkbnKvqrBnVMXD65grsLSTKXr2p0u6uPnOip3AmmnuHezAYTOCT040aHJNBprUYOVfdQkGZM2uWMAnowpVkyPRNjtng0C1cIfxy3PeY73dFJHbvVWO/PG0UoYNJZsYZe2+kIw+egSCIC12xBFgtc9acqf+stMn34cc7s6g6jb84UhzliGagnfCzkmU41+4i2uKCslL7YxxlnjkUiDcQDSnl9mLlI5gYrUMXWPZkImESkkJoPqOx73PlIYMO8GMsVNNZQd/g99Tv+PMveYYEf81s8Qxp8S23TPPo5kRKRs2N51t+SqNnIbHmQa0oMSSYptFdLxFW3UZYmO+irtDSrRLt1Ag6MqDXcelN4uXmP/AKxt0zgwmNoGx+gZ5POnFTIVnufDytO9Ifz7PYVdBcwdHLnkh2ZSkzLOzDCKFFFE2zHlLLTUmlW5wfOP4WrRpDn/AXZelfCv2KTqWc997vjGj/K/65w08NWE1Q+6g4+0bzrcYlPDhBqDqj8b+UHaTD0p+8plKyWHLJDswwPPQqCQCeN3DR/L83mTBs86wfhZYKh5QdJV2vqEDW9TVyNNi+sg4XXeAYqnUaLUUpgHaYn0tlCBZSzr+flB3dlP/oVULcAA1a0xwdzQg4iNG04lSy2Sl7A9Vvr9YXMTDoduD18vvlVPXrFNHfrPvdX7yM8ivOG1WEgBsK66WSJOnu+vU5tsXDagBgkwWEaUqF0CiiKeWZGUkdoOYxoGxIbtEqOtvTscbYyNNtXpTnix0IgR/MpWOMvPocNLvZKh4wlM+iepW22aSllxCO0AwEHW9/HVqUgxTe7Ac09QyheIGN56a5Pi4N4PFmckzaP15nwtvQ24QuqP93KBM/bcD5uXB6M8vrQePgK7iR1gL3IaXem6Yxmpcp8CyPujjoEN2m2aJ+OOMTJEj+CJfWEt84ptBNUf/HB/6Mthh6DDAPflHc7zk1P9tJPK6U7BiqB0sxQ3o9YEEvPm+P9qplgezhysyLODjRPnFShIJyvHlWVn6JRLu3JoU2sEtaCK+750F7PcvKWT0MYEvgO+0db7ZhbooRfjt2CqqPeqkhsXu4ioC033agdw1VbrWnVsa6Sl+uyortuaBDQoADB0vom+XaswDIyfdGT6X0KfLl9J/GB+jnBN51VgXpIxOenwOxPrRqQjsnpfM59tPzFwThI+a0ne925ArR0fNEcZNtSTAnt8ErZXerYKiT9EfDMgK97VJAqAMMENPp5msbCjWmtFv0K6YvYxOQxYEqE5aNTtpH49+BNWrBw8xtlS11TGFYF2Qz5orvJN/U7TN7bk/z4+G9HKGZ7oMvXSGDXr/rwU3QL0ZIWEF4mKTUG5FF3wGhV1gokdGpMxL/oN+oW9WLN3dGfwUKYLXnkbtZrRxNinXY+gdC2qIS+ov9tTcDpcIL5oCMJJf+P3GlWNa/T5m3/o7pqjRTrUke+EInGEz0+/Vv8hNyI+bnAIKgMIQYvCDXjJs8VomJy/hl8dzs2PBiY0npAQNz88qGb1XIRjSTMKlWJLpAJVYv6lC9u1t1eA3tFPaDyY04J90/ILhjjzyWJUq4G4UfgJ0WwuTNTArOqn1bkGlqwXgh+DnZ7r2U/fC629+7VK66jHOFf+NgDIM0CbypqswOaIcUJT56CXaTJJ7pzRu70DFIW6sGG1aQr8552z5s1nH4NV1hhYUDZYsSN2Ng100L13zAnjs03Zia2KdDeuWC/6PiMp1zbtSq39kB6rN2EFHKWuf3neklEAwVYYDCc2TPOFxksNykAGC0eOIN1UUB48iwFkNZujkMH9KRIPI6QpBtpfPaRvNsfVKpVIz1eQI1cd3Jz7rNQCC9luigQiiVZ2fJXGJY+KblpB4vyGzw9iSBiaovH73+uM4Mnj2NRMiOXpt+uWFqm+UX14cys5FRdV+i0sDVtQ7GX3x40XAUWCnARPpMCYO0TNWeRd9dMlnX9r5iHt3qJhLSxSHDp5VDrQXnDIGX846JY7+5QVtoF7mhR+iNnoWkqfpvfVj37Ym10iUcQO9076iEqY+eN2rJqsjK3xoFva4uzxBCRhg4i5NhfnhdsNkz2+9wbBizN7ZYpY0wBo1D/rcUEt7nxNSfgTPZ7VHjK4Oq+3KEvRfwbNFx3bRpCE4Ut6GcOR7wzhnp5A+1EQbI90TrNtBneTfsgLuHatBAfZESkKcm6252oYBF7Slxk/e4xjHOrRtji6Kvz1CvOSQmlJnShXiK6xovnx3JrESKa4MNHp5LZVB9li3MH0D9ctA1l0HHTmnlPvgxNKsvx9bxzmQvRsqV9gaLNBpEzdlF44CUH1stfky/GM3bx+kNJSKD7lrDAGW/Esl3HQRQu1taZ4XJ6gpd5Dew4yPFOkmB0qZpTMsVot/5ltSxN31akNK5IV1AgOrGJ40YW6mC+LwLkF75dqq60vFUGVPhnjw3UQWbr08BvDJxvmhD7bWVtJVB/29K4VPvO1YETsbQik3NBD0VwB2Oi53SJh27/WcqQAR8ok75Qs7AkuhqPoTSgchNpCe4KKF/cGrvcnuwRlsyqhZ1HYXMgfY7nOtzqrizvKqpB6jLZl4IGvqxHAjsL9PctUET4WPJJ/nzXVSrH2AyPhrpVYgRcchadgICiCEGUj8set52n615dNmyenPUAPwKqYzIaO3V4dchTvVZQ65BeV99nVhESaNTdj3U3g4G734/uapzhLXOBL4zdC84ki2LuS9XBU91QI/PRitU1HXXDEXMa3TWRJD7jaZp7uHrqIZSszbhborTg8iL4ecTL5cx035oLci8+HPQ149quFKeNdpvVYRrjBoyO3VK8s1bTgwdmAv2c90SGtBKDgLkrLUX/w+Tt7ufe4ooCr3xiCJTF9aOT43e1/4PJ7Wf1Z2ExheZVGqzQFpKz5HYBx4bPlGxP8iJ/FRw0+cqOEMeTJu1Y30vNfd+r96APbsHLDDeoB/pQlS0yxthlP+zSZ15mIckF7kMyTtITEsgnjuzF2qDVxfMRH05C/mKv1mmAxeiTuMSwQMO6y5BU1JZ3MzBDVhz85q98Aukzh2Sn1tuZumM/Abg1+EfJ6Jl1scFSenPQ/WxCCyHD31eBd3Rvv1kOdxeM73+9RMBX3PQRrY6Epm+QsNWjCHOSqLf8VTBuAaIW79mZH7/JLTb9GZPcHfPJIYKYyYWJTgLJ98B7yxFSysw7hG9irFsyP8TKabu5d2Q6Kvw7shYxMfUdK0p6rxQ/BkOqXI8I+N+f6bC9bCFu4mD6XDSCbDb8Db6GsF2Nx1S5nWzuQa1Ci/3RW19iBZbdUmLM+TdGJO/3RjFu58nf/ISdxHhr+x7pCe+AeM71J7PP9XyOWRQc07ixL5lVUDhKqymKcFz505TXea8iTJ8h8zlRQKEf4AslFbafIApZYMJ5FIdGrSBYi9OM599vgbS7yANfnA1eTCe4wE+63444GSQwcj2Zj7ByL7Jlh8PE09E2NksuSzKU4z1738AYniO/RN2OnLrHtub/a3iZpzNItaIhYNN+T5DgpfHr0t0Wifj+jfxaWsuqKWxkJgWi7yxhzvtuJjjIt/QVYPXhMS/0YmQGjOlo7jO759zswah4zjAA4qdOHZnepIjbm3gZC7ZafptR52bCNjRnz6IzG2HnO3wnzKvVefywFKdnzjyloTb3WrjQjR7fsHRu1H8QN2KYu8xT901j7MBMXcB+OTBykiV9hCx7PcTQ+uSkUDJohevytW4dpy4NMwM48VQygtoTFIO1Enf3l2zC6P1H0BncgPxRwA3CfT0k8H4793q+zwxdTDqGpruuCllPaYlQF9GuQvTTUegZP/Sb9X5Ehiawi9wmCRdW+wmwTSm2RMk44/JEqHzgpvHsi3JuWePjhM7nFwi5xPg5mv9fkps0uSC5J08QbEsMgADY/HOvq9ycApy/Il9cJySTrAkTVkWMvI2UI57i9Cqsdduzo6y1vxrmHtoJ51Dn2atoGKvpXp+qseLOnFKplSHCLasuyFj4/Mi+kDzbXOLRO/0/VQ32u0YYlKa0aqgvXBPGFlwAcyprU6LncxzCIFpFwHQq6TKOBeOsN6UL01wJ4vOfU1pYLNoxQ8TMud+VwBusIK7aI61qkBSYniExomgXXuNSBusFc/B8kiUnFYSzX21lefbNPEjeF59YFjcynVaB6X1UWtyzSR+bcI50kgqXUyNKrZp+cka3QH4w6hXV2/iC0D3nVc/46XVvgkbyXmtbsdj2z3s3pZRZuAs3cJbgeJvb8zaTT08iH5ekrFXX9y4UpJtOAsEDL41oVb6Mk2LI09BYTmKZgxYC490bOfa/hzOoUJRngA3n78VY4rTbL6ZHYyKySw/Lh9YoSWjeaSIyPNGdxOQeKXZkQuR3z/zOb+0UzJK1jkC7O702Yo37PkOOXkmU69QPr0LKTnHjl2mcEUNJu5D9vi8pVWb4Tg5Sr/GVHcYkX73H4R0Br1+Cm801PUJN52Fyge20zQo6iM+u5VKY//f4TQ8mSZXqJJqkwrw8xH+H6Reuus/DLj4AEbfcp2zXE1Eetv8+TOHWner+NtPgyiOoaFdCsApDCnOvXcB8VZvMI++XLf5fX0kc3H40g0C4As1tLwXy/RFQtpTaeKTWg3TMuHSbGZVszAjDQZNtKuYGzE/92IO7XhPjTwyO2p1v0MQyrMCiAxEYJya99jFSqDJ1xPZuiQ6uTJMzxZ3M2+PEI1yRyuPmxIqqyBxLLAV+iES1rg6tsHVQ9YaHicH10PlgZIJcAeJilpkT8lAPZSs4XfOg3PQVCNXhf1EGyg/wJkcfCTJVr0helPqgcLxEYMKbU7JeJNRqR6u2ADPTrJceJphtVD1Iv/BgxpMkD3I0714o3G9EcY7+Sn+dxHeSDvH37wQmfYMNIUduacgy8WFCg/PrrK8v465ZmTBNRD2r+GWUsc9kwEb0H9sGKTggte6SmWf1O5xZGgi94FvF41XS1k5A2SxrudAZf9UT40Vj7hsJVXJ5AfATLKuPAlsqNi7OR/MQp1LLFkSgCwjy5aKkWIxUQt+sGz3wIPaczc049NjAgU7e+LYIqIaj4UIFvt335LROSNztErZ5hKspW50YMqhKyXaL207/7rjUFSgoje6Q8Yktweg85Hh07B2swTGsYn6GMSyDVOBRbO99VLSpA0Y64q0GsWwtUiYy3gHW+OfCE6ZdDt8Zzq3QfLXTOotpHgps75+wkG6CG37KE1f83B6O6eIOAZv2TiXB6L1iQ4JnnXY4tJTFealO+Ey/rA3JYJNX9yQ4ZU0uFKacv6UZXKdPCbKtmNg2U6EWjf/kTWXaC1aKhxr2N7FtqmHy+/9nFQdYhihNqN1LghDfPRi8cDLP0GVYZ6Xyr+IszbQPVe2e4bb5h4IV01iNf9QGh1SVqpd8g+w/jqYP2X84jaOaXIaeVOFYQTnPrUIbUEYcjM7mGFmMdzBgaCwKt9EiZZn+FO508Mmyk6SMzTmDgbRnohJyqAKBGADfJPLVPRhQ==" /> </div> <script type="text/javascript"> //<![CDATA[ var theForm = document.forms['form1']; if (!theForm) { theForm = document.form1; } function __doPostBack(eventTarget, eventArgument) { if (!theForm.onsubmit || (theForm.onsubmit() != false)) { theForm.__EVENTTARGET.value = eventTarget; theForm.__EVENTARGUMENT.value = eventArgument; theForm.submit(); } } //]]> </script> <script src="/WebResource.axd?d=pynGkmcFUV13He1Qd6_TZDkCPVD1CEgIJIwX-djYyD12MdD7MbGguneDtbgL0T4_DTGNirF3uaaW3m5irAIXOA2&t=638628207619783110" type="text/javascript"></script> <script id="dxis_725862373" src="/DXR.axd?r=1_304-HCSds" type="text/javascript"></script><script id="dxis_117419880" src="/DXR.axd?r=1_185-HCSds" type="text/javascript"></script><script id="dxis_2117664241" src="/DXR.axd?r=1_188-HCSds" type="text/javascript"></script> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATEGENERATOR" id="__VIEWSTATEGENERATOR" value="54D499A9" /> <input type="hidden" name="__EVENTVALIDATION" id="__EVENTVALIDATION" value="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" /> </div> <input type="hidden"/><script id="dxis_1899801520" src="/DXR.axd?r=1_298,1_211,1_221,1_182,1_277,1_198,1_209,1_217,1_190,1_223,1_208,1_290,1_206,1_288,1_212,1_286,1_296,1_299,1_224,1_201,1_216-HCSds" type="text/javascript"></script><table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="ASPxLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="width:0px;vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="ASPxLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="ASPxLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1948350305" type="text/javascript">  </script> <div class="top-part cl"> <div class="top-content" id="top"> <ul class="ul"> <li class="logo fl"> <a href="https://www.wjgnet.com" target="_blank"> <img src="/Contents/Images/Bpg-logo-new.svg" /> </a> </li> <li class="rca-title fl"> <a href="/" class="clearlink"> <img src="../Contents/Images/RCA-Logo.svg" alt="Reference Citation Analysis" /> </a> </li> <li id="PageTopControl_loginContainer" class="logined fr"> <table> <tr> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_Login" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_Login_I" class="dxb-hb" value="Login" type="submit" name="ctl00$PageTopControl$Login" /><span class="dx-vam">Login</span> </div> </div><script id="dxss_309739120" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_AuthorRegist" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_AuthorRegist_I" class="dxb-hb" value="Scholar Register" type="submit" name="ctl00$PageTopControl$AuthorRegist" /><span class="dx-vam">Scholar Register</span> </div> </div><script id="dxss_216236472" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_BusinessRegist" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_BusinessRegist_I" class="dxb-hb" value="Business Register" type="submit" name="ctl00$PageTopControl$BusinessRegist" /><span class="dx-vam">Business Register</span> </div> </div><script id="dxss_1760396766" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_Subscribe" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_Subscribe_I" class="dxb-hb" value="Subscribe" type="submit" name="ctl00$PageTopControl$Subscribe" /><span class="dx-vam">Subscribe</span> </div> </div><script id="dxss_1089838522" type="text/javascript">  </script> </td> </tr> </table> </li> </ul> </div> </div> <div class="main-part cl"> <div class="main-search-container"> <div class="search-form search-centered"> <div class="search-component-container"> <ul class="ul cl"> <li class="fl"> <table id="FieldItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="FieldItems_TL">Loading…</span></td> </tr> </table><div id="FieldItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox FieldItems" id="FieldItems"> <tr> <td style="display:none;"><input id="FieldItems_VI" name="FieldItems_VI" type="hidden" value="mesh" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="FieldItems_I" name="ctl00$FieldItems" onfocus="ASPx.EGotFocus('FieldItems')" onblur="ASPx.ELostFocus('FieldItems')" onchange="ASPx.ETextChanged('FieldItems')" value="MESH Heading" type="text" /></td><td id="FieldItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="FieldItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="FieldItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="FieldItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="FieldItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="FieldItems_DDD_L_VI" type="hidden" name="ctl00$FieldItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="FieldItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="FieldItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="FieldItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Article Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Abstract</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Keyword</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Category</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">MESH Heading</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Grant Agency</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">RCAID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">DOI</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMCID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Author</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Affiliation</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Email</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Journal Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">ISSN</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Publisher</td> </tr> </table> </div></td> </tr> </table><script id="dxss_153608340" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1280586772" type="text/javascript">  </script><script id="dxss_14646264" type="text/javascript">  </script> </li> <li class="fl"> <table id="OpeartorItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="OpeartorItems_TL">Loading…</span></td> </tr> </table><div id="OpeartorItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox OpeartorItems" id="OpeartorItems"> <tr> <td style="display:none;"><input id="OpeartorItems_VI" name="OpeartorItems_VI" type="hidden" value="Equals" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="OpeartorItems_I" name="ctl00$OpeartorItems" onfocus="ASPx.EGotFocus('OpeartorItems')" onblur="ASPx.ELostFocus('OpeartorItems')" onchange="ASPx.ETextChanged('OpeartorItems')" value="Equals" type="text" /></td><td id="OpeartorItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="OpeartorItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="OpeartorItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="OpeartorItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="OpeartorItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="OpeartorItems_DDD_L_VI" type="hidden" name="ctl00$OpeartorItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="OpeartorItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="OpeartorItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="OpeartorItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Contains</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Equals</td> </tr> </table> </div></td> </tr> </table><script id="dxss_597138281" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_24426426" type="text/javascript">  </script><script id="dxss_1793334323" type="text/javascript">  </script> </li> <li id="TermInputContainer" class="fl TermInputContainer"> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue input-text SearchTermText dxeTextBoxDefaultWidthSys" id="SearchTerm"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="SearchTerm_I" name="ctl00$SearchTerm" onfocus="ASPx.EGotFocus('SearchTerm')" onblur="ASPx.ELostFocus('SearchTerm')" onchange="ASPx.EValueChanged('SearchTerm')" value="Drug Resistant Epilepsy/genetics" type="text" /></td> </tr> </table><script id="dxss_543298418" type="text/javascript">  </script> <span class="search-icon-container"> <a class="search-icon" href="javascript:openCategorySelector(1);"><img src="/Contents/Images/search.png" /></a> </span> </li> <li class="fl"> <div class="dxbButton_MetropolisBlue SearchButton dxbButtonSys dxbTSys" id="SearchArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="SearchArticle_I" class="dxb-hb" value="Find an Article" type="submit" name="ctl00$SearchArticle" /><span class="dx-vam">Find an Article</span> </div> </div><script id="dxss_842240986" type="text/javascript">  </script> </li> </ul> <div class="cl"></div> <div class="search-menu"> <span>Find an Article (55822924)</span>   <a href="/Categories" target="_blank">Find a Category (125)</a>   <a href="/SearchJournal" target="_blank">Find a Journal (6158)</a>   <a href="/searchscholar" target="_blank">Find a Scholar (3749)</a>   <a href="/searchacademicassistant" target="_blank">Find an Academic Assistant (18)</a> </div> <div class="search-menu" style="text-align:center;"> <span>Find an Article PDF (4649766)</span>   <a href="/TodayArticles" target="_self">Today's Articles (0)</a>   <span>Subscriber (50856)</span> </div> </div> </div> </div> <script src="/bundles/UserAcademicAchievement?v=QYKvd9c2mOpOgKt90go7osO6NdxcNzivChzWAq_gw3g1"></script> <script type="text/javascript"> $(function () { try { var sort = getQueryString2('sort'); if (sort != null && sort != '') { if ($("[field='st" + sort + "']").length) { $("[field='st" + sort + "']").addClass("sort-highlight"); } if ($("#" + sort + "sortedCheck").length) { $("#" + sort + "sortedCheck").prop("checked", true); } } $("a.readmore").click(function () { $(this).parent().toggle().next().toggle(); }); $("a.readless").click(function () { $(this).parent().toggle().prev().toggle(); }); var action = getQueryString2('action'); if (action != null && action != '') { if ($("a[name='" + action + "']").length) { $("a[name='" + action + "']").first().click(); } } InitializeResultAnalysisBtn(); } catch (e) { } try { $(".file-container-btn").each(function () { var itemCount = parseInt($(this).attr("item-count")); if (itemCount > 0) { $(this).click(function () { var controlId = $(this).attr("aria-controls"); $("#" + controlId).toggle(); var fa = $(this).children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } }); } }); InitAchievementContents(true); InitYearFacets(); setTimeout(() => setUserContainerBorder(), 1000); setTimeout(() => setUserContainerBorder(), 2000); setTimeout(() => setUserContainerBorder(), 5000); } catch (e) { } AddVisitRecord(2); }); function DeleteArticle(doi) { if (confirm("Confirm Delete the Artilce?")) { LoadingPanel.Show(); try { if (doi != '') { var uri = "/api/BpgUser/DeleteArticle?doi=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, async: false, success: function () { window.location.href = window.location.href; } }); } } catch (e) { } finally { LoadingPanel.Hide(); } } } function Refresh() { CloseEdit(); window.location.href = window.location.href; } function CloseEdit() { pcEditArticleControl.Hide(); } function EditArticle(doi) { pcEditArticleControl.SetContentUrl("/EditUserArticle?Id=" + encodeURIComponent(doi)); pcEditArticleControl.Show(); } function setUserContainerBorder() { try { var leftContainerHeight = $('.user-info-center-container .left-part').outerHeight(); var rightContainerHeight = $('.user-info-center-container .right-part').outerHeight(); if (leftContainerHeight > rightContainerHeight) { $('.user-info-center-container .left-part').css('border-right', '1px solid #C0C0C0'); $('.user-info-center-container .right-part').css('border-left', ''); } else { $('.user-info-center-container .right-part').css('border-left', '1px solid #C0C0C0'); $('.user-info-center-container .left-part').css('border-right', ''); } } catch (e) { } } function ShowUserFriendList() { var expandContainer = $(".expandUserFriend"); $(".user-friend-list").toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function ShowUserContainerList(className, listClassName) { var expandContainer = $("." + className); $("." + listClassName).toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function OpenMessage(id, friendId) { OpenFriendMessage(friendId); $("div[name='countcontainer" + id + "']").hide(); } function DeleteFriend(id) { if (confirm("Confirm Delete the Friend?")) { LoadingPanel.Show(); var uri = "/api/BpgUser/DeleteFriend?id=" + id; $.ajax({ type: "get", url: uri, async: false }).done(function () { window.location.href = window.location.href; }); } } function SelectAllFriend() { $("input[name='checkfriend']").each(function () { $(this).attr("checked", $('#selectAllFriend').prop("checked")); }); onCheckFriendClick(); } function onCheckFriendClick() { var itemArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); }); if (itemArray.length > 0) { $("#BatchMessageContainer").show(); } else { $("#BatchMessageContainer").hide(); } } function SendBatchMessages() { var itemArray = new Array(); var idArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); idArray.push($(this).attr("data-id")); }); if (itemArray.length > 0) { if (itemArray.length == 1) { OpenMessage(idArray[0], itemArray[0]); } else { var friendIds = JSON.stringify(itemArray); OpenBatchFriendMessage(friendIds); } } } function ImportSingleArticle(doi, controlId) { if (doi != '') { LoadingPanel.Show(); var uri = "/api/BpgUser/ImportArticle?doiPmid=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function (data) { LoadingPanel.Hide(); if (data) { alert("Import Successfully!"); var currentControl = $("#" + controlId); currentControl.parent().hide(); } }).always(function () { LoadingPanel.Hide(); }); } } function ImportAllArticles() { LoadingPanel.Show(); var term = getQueryString2('term'); var uri = "/api/BpgUser/ImportArticlesFromSearch?term=" + term; $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function () { LoadingPanel.Hide(); alert("Imorting is executing!"); }).always(function () { LoadingPanel.Hide(); }); } </script> <input type="hidden" name="ctl00$RootHolder$RCAId" id="RCAId" /> <input type="hidden" name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">89</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (10)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (35)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Drug Resistant Epilepsy/genetics</label> </div> <div id="yearFacetContainer"> <div class="mnavbar"> <div> Year Published </div> </div> <div class="mnavbox"> <div id="yearFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('year');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refineyearcheck" target="_self">Refine</a> </div> </div> </div> <div id="jsFacetContainer"> <div class="mnavbar"> <div> Article Statistics </div> </div> <div class="mnavbox"> <div id="jsFacetItemContainer"> </div> <div class="refine-btn-container cl" name="refinejscheck"> <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejscheck" target="_self">Refine</a> </div> </div> </div> <div class="mnavbar"> <div> Ranked By </div> </div> <div class="mnavbox"> <ul class="ul sortedby-list"> <li> <input type="radio" id="aisortedCheck" onclick="SetSorted('ai')" name="sortedbycheck" value="aisorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('ai')" id="aisorted">Impact Index Per Article</a> </li> <li> <input type="radio" id="citedf6sortedCheck" onclick="SetSorted('citedf6')" name="sortedbycheck" value="citedf6sorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('citedf6')" id="citedf6sorted"> Citation(s) in <i>RCA</i> </a> </li> </ul> </div> <div id="RootHolder_ResultsAnalysisContainer"> <div class="mnavbar"> <div> Results Analysis </div> </div> <div class="mnavbox"> <ul class="ul analysis-list"> <li> <input type="checkbox" id="YearAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="year" />  <label for="YearAnalysis">Year Published Analysis</label> </li> <li> <input type="checkbox" id="ArticleTypeAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="at" />  <label for="ArticleTypeAnalysis">Article Type Analysis</label> </li> <li> <input type="checkbox" id="JournalTitleAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="journal" />  <label for="JournalTitleAnalysis">Publication Title Analysis</label> </li> <li> <input type="checkbox" id="CategoriesAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="subject" />  <label for="CategoriesAnalysis">Category Analysis</label> </li> </ul> <div class="refine-btn-container cl" name="analysis-check-btn-container"> <a href="javascript:ResultAnalysis();" class="refine-link-btn refine-link-btn-right" target="_self">Results Analysis</a> </div> </div> </div> <div class="refine-btn-container-n cl" id="showFacetsContainer"> <a href="javascript:InitAllFacets();" class="refine-link-btn-right" target="_self">Show more</a> </div> <div id="facetsContainer" class="cl" style="display: none;"> <div class="mnavbar" id="PubDateFacetTitle"> <div> Indexed Articles </div> </div> <div class="mnavbox" id="PubDateFacetContainer"> <ul class="ul sortedby-list"> <li> <a href="javascript:SubmitSingleFacetSearch('create','6');">Today (<span id="indexCount6"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','5');">Yesterday (<span id="indexCount5"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','4');">This Week (<span id="indexCount4"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','3');">Last Week (<span id="indexCount3"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','2');">Current Month (<span id="indexCount2"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','1');">Last Month (<span id="indexCount1"></span>)</a> </li> </ul> </div> <div id="journalFacetContainer"> <div class="mnavbar"> <div> Publication Titles </div> </div> <div class="mnavbox"> <div id="journalFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('journal');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejournalcheck" target="_self">Refine</a> </div> </div> </div> <div id="fundFacetContainer"> <div class="mnavbar"> <div> Grant Agencies </div> </div> <div class="mnavbox"> <div id="fundFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('fund');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinefundcheck" target="_self">Refine</a> </div> </div> </div> <div id="subjectFacetContainer"> <div class="mnavbar"> <div> Category </div> </div> <div class="mnavbox"> <div id="subjectFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('subject');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Samões R</b>, Cavalheiro A, Santos C, Lopes J, Teixeira C, Tavares MM, Carvalho C, Lemos C, E Costa PP, Cavaco S, Chaves J, Leal B. MicroRNAs as potential biomarkers of response to modified Atkins diet in treatment of adults with drug-resistant epilepsy: A proof-of-concept study. <em class='incite-journal-name' onclick='ShowInCiteJournal(8659);'>Epilepsy Res</em> 2024;<b>208</b>:107478. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39536682' target='_blank'>39536682</a> DOI: <a href='https://dx.doi.org/10.1016/j.eplepsyres.2024.107478' target='_blank'>10.1016/j.eplepsyres.2024.107478</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.eplepsyres.2024.107478','39536682', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.eplepsyres.2024.107478' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8659);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.eplepsyres.2024.107478" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Accurate predictors of response to modified Atkins diet (MAD) are needed. MicroRNAs are potential biomarkers in epilepsy. This study aimed to explore the value of circulating miR-146a, miR-155, miR-22, miR-21 and miR-134 levels in predicting response to MAD. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Patients who completed 3 months of MAD were selected from a prospective cohort of adults with DRE followed in a specialized MAD outpatient clinic. Patients were classified as responders if any reduction in seizure frequency at follow-up, calculated through seizure-calendars). The >50 % seizure reduction cut-off was also explored. Qualitative benefits in seizures and cognition were analysed. Blood samples were collected prior to initiate MAD and microRNAs were quantified by qRT-PCR. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Thirty-nine patients were included (56 %males, mean age=33.1±8.5yo, 62 %focal epilepsies, 59 %structural aetiology): 20(51 %) were responders [mean reduction in seizure frequency=54 %(17-100 %); 10 had ≥50 % reduction]; 25(64 %) reported qualitative benefit in seizures and 21(54 %) reported cognitive benefits. At pre-treatment baseline, a panel combining serum levels of all studied microRNAs predicted seizure reduction (AUC=0.839, p<0.0001), qualitative benefit in seizures (AUC=0.683, p=0.048) and in cognition (AUC=0.751, p<0.01) at 3months. miR-146a was the only significant microRNA when evaluated in isolation. There was no statistical correlation in the biomarkers when a ≥50 % seizure reduction was compared to <50 %. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">A panel combining pre-treatment serum levels of miR-146a, miR-155, miR-134, miR-21 and miR-22 predicted any reduction in seizures with MAD in adults with DRE at 3months. This panel may be a promising biomarker and a useful tool in the selection of patients. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+response+biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug response biomarkers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ketogenic+diet%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ketogenic diet</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mechanism+of+action%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mechanism of action</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdiet+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/diet therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Protein+Low-Carbohydrate%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Protein Low-Carbohydrate/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proof+of+Concept+Study%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proof of Concept Study</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%2fdiet+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures/diet therapy</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Liu T</b>, Wang S, Tang Y, Jiang S, Lin H, Li F, Yao D, Zhu X, Luo C, Li Q. Structural and functional alterations in MRI-negative drug-resistant epilepsy and associated gene expression features. <em class='incite-journal-name' onclick='ShowInCiteJournal(17813);'>Neuroimage</em> 2024;<b>302</b>:120908. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39490944' target='_blank'>39490944</a> DOI: <a href='https://dx.doi.org/10.1016/j.neuroimage.2024.120908' target='_blank'>10.1016/j.neuroimage.2024.120908</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.neuroimage.2024.120908','39490944', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.neuroimage.2024.120908' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17813);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.neuroimage.2024.120908" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neuroimaging techniques have been widely used in the study of epilepsy. However, structural and functional changes in the MRI-negative drug-resistant epilepsy (DRE) and the genetic mechanisms behind the structural alterations remain poorly understood. Using structural and functional MRI, we analyzed gray matter volume (GMV) and regional homogeneity (ReHo) in DRE, drug-sensitive epilepsy (DSE) and healthy controls. Gene expression data from Allen human brain atlas and GMV/ReHo were evaluated to obtain drug resistance-related and epilepsy-associated gene expression and compared with real transcriptional data in blood. We found structural and functional alterations in the cerebellum of DRE patients, which may be related to the mechanisms of drug resistance in DRE. Our study confirms that changes in brain morphology and regional activity in DRE patients may be associated with abnormal gene expression related to nervous system development. And SP1, as an important transcription factor, plays an important role in the mechanism of drug resistance. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug-resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug-resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+expression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene expression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gray+matter+volume%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gray matter volume</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Regional+homogeneity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Regional homogeneity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription-neuroimaging+association+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription-neuroimaging association analysis</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gray+Matter%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gray Matter/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gray+Matter%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gray Matter/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Tong X</b>, Wang Q, Yang J, Zhou J, Chen X, Gan J, Cai Q, Yu T, Luo R. Optimizing ketogenic diet therapy for childhood epilepsy: Identifying key factors for seizure control and psychomotor enhancement. <em class='incite-journal-name' onclick='ShowInCiteJournal(8564);'>Epilepsia</em> 2024;<b>65</b>:2959-2972. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39190400' target='_blank'>39190400</a> DOI: <a href='https://dx.doi.org/10.1111/epi.18098' target='_blank'>10.1111/epi.18098</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/epi.18098','39190400', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(3);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/epi.18098' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8564);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1111/epi.18098" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">To identify key factors influencing the therapeutic efficacy of the ketogenic diet (KD) for children with drug-resistant epilepsy and elucidate their interconnected relationships to optimize clinical practice. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Participants were selected from children receiving KD treatment at West Second University Hospital of Sichuan University from September 2015 to October 2023. Clinical factors pre-KD and post-KD (at the third month) were analyzed systematically using an analytical framework. Descriptive analyses, univariate analyses, and multivariate regression analyses were performed for the entire cohort and subgroups of genetic and non-genetic (i.e., structural and unknown) etiologies. Thereby, the most significant predictors were identified for each relevant dependent variable. Path analysis diagrams were used for visual representation. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Of 156 patients, genetic etiology was prevalent (38.5%). In the genetic subgroup, channelopathies predicted lower baseline seizure frequency and increased chance of seizure freedom with KD. Frequent seizures and complex history of anti-seizure medications (ASMs) predicted severe baseline psychomotor abnormalities. Younger age at KD initiation benefited psychomotor improvement. In the non-genetic subgroup, lower baseline seizure frequency increased the likelihood of seizure freedom post-KD. Concurrent use of multiple ASMs helped achieve ≥50% seizure reduction. Boys were more likely to experience psychomotor improvement. A significant correlation was found between ≥50% seizure reduction and psychomotor improvement in both subgroups. Delayed KD initiation (longer epilepsy duration at KD start) was related to a greater number of ASMs used, infrequent seizures, and older age at epilepsy onset. In addition, patients with channelopathies had delayed initiation of KD. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">Children with genetic epilepsy display more pronounced characteristics of epileptic encephalopathy. Early KD intervention is crucial for channelopathies, notably SCN1A variants. For other drug-resistant epilepsy cases, KD alongside diverse ASMs may improve seizure control and developmental outcomes. However, the patient population benefiting most from early KD tends to start the treatment later, urging a re-evaluation of KD decision-making paradigms. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug%e2%80%90resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug‐resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22etiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ketogenic+diet%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ketogenic diet</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22predictive+factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">predictive factors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22therapeutic+efficacy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">therapeutic efficacy</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+Ketogenic%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, Ketogenic/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdiet+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/diet therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%2fdiet+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures/diet therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticonvulsants%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticonvulsants/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Psychomotor+Performance%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Psychomotor Performance/physiology</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82101523 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Key+Research+and+Development+Program+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2021YFC1005305 National Key Research and Development Program of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Horizontal+Scientific+Research+Project+of+Sichuan+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">20H0072 Horizontal Scientific Research Project of Sichuan University</a></li></ul> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Marques P</b>, Moloney PB, Ji C, Zulfiqar Ali Q, Ramesh A, Goldstein DB, Barboza K, Chandran I, Rong M, Selvarajah A, Qaiser F, Lira VST, Valiante TA, Bazil CW, Choi H, Devinsky O, Depondt C, O'Brien T, Perucca P, Sen A, Dugan P, Sands TT, Delanty N, Andrade DM. Do germline genetic variants influence surgical outcomes in drug-resistant epilepsy? <em class='incite-journal-name' onclick='ShowInCiteJournal(8659);'>Epilepsy Res</em> 2024;<b>206</b>:107425. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39168079' target='_blank'>39168079</a> DOI: <a href='https://dx.doi.org/10.1016/j.eplepsyres.2024.107425' target='_blank'>10.1016/j.eplepsyres.2024.107425</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.eplepsyres.2024.107425','39168079', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.eplepsyres.2024.107425' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8659);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/23/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.eplepsyres.2024.107425" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">We retrospectively explored patients with drug-resistant epilepsy (DRE) who previously underwent presurgical evaluation to identify correlations between surgical outcomes and pathogenic variants in epilepsy genes. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Through an international collaboration, we evaluated adult DRE patients who were screened for surgical candidacy. Patients with pathogenic (P) or likely pathogenic (LP) germline variants in genes relevant to their epilepsy were included, regardless of whether the genetic diagnosis was made before or after the presurgical evaluation. Patients were divided into two groups: resective surgery (RS) and non-resective surgery candidates (NRSC), with the latter group further divided into: palliative surgery (vagus nerve stimulation, deep brain stimulation, responsive neurostimulation or corpus callosotomy) and no surgery. We compared surgical candidacy evaluations and postsurgical outcomes in patients with different genetic abnormalities. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">We identified 142 patients with P/LP variants. After presurgical evaluation, 36 patients underwent RS, while 106 patients were NRSC. Patients with variants in ion channel and synaptic transmission genes were more common in the NRSC group (48 %), compared with the RS group (14 %) (p<0.001). Most patients in the RS group had tuberous sclerosis complex. Almost half (17/36, 47 %) in the RS group had Engel class I or II outcomes. Patients with channelopathies were less likely to undergo a surgical procedure than patients with mTORopathies, but when deemed suitable for resection had better surgical outcomes (71 % versus 41 % with Engel I/II). Within the NRSC group, 40 underwent palliative surgery, with 26/40 (65 %) having ≥50 % seizure reduction after mean follow-up of 11 years. Favourable palliative surgery outcomes were observed across a diverse range of genetic epilepsies. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">Genomic findings, including a channelopathy diagnosis, should not preclude presurgical evaluation or epilepsy surgery, and appropriately selected cases may have good surgical outcomes. Prospective registries of patients with monogenic epilepsies who undergo epilepsy surgery can provide additional insights on outcomes. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy+surgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Germline%c2%a0variants%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Germline variants</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Surgical+assessment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Surgical assessment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Surgical+genomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Surgical genomics</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Germ-Line+Mutation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Germ-Line Mutation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurosurgical+Procedures%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurosurgical Procedures/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Variation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Variation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Favaro J</b>, Iodice A, Nosadini M, Asta F, Toldo I, Ancona C, Cavaliere E, Pelizza MF, Casara G, Parmeggiani L, Sartori S. PPP3CA gene-related developmental and epileptic encephalopathy: Expanding the electro-clinical phenotype. <em class='incite-journal-name' onclick='ShowInCiteJournal(169208);'>Seizure</em> 2024;<b>121</b>:253-261. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39305655' target='_blank'>39305655</a> DOI: <a href='https://dx.doi.org/10.1016/j.seizure.2024.08.017' target='_blank'>10.1016/j.seizure.2024.08.017</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.seizure.2024.08.017','39305655', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.seizure.2024.08.017' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169208);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/08/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.seizure.2024.08.017" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">PURPOSE</div><div class="abstract-content">The objective of this study is to characterize the electro-clinical phenotype of individuals affected by the rare PPP3CA gene-related developmental and epileptic encephalopathy (DEE). </div><div class="abstract-label">METHODS</div><div class="abstract-content">We provide a detailed electro-clinical description of four previously unreported subjects, with unremarkable structural brain MRI and a normal screening for inborn errors of metabolism, who carry pathogenic variants within the regulatory domain of the PPP3CA gene, which encodes for calcineurin. We also conducted a literature review via PubMed and SCOPUS (up to December 2023) to collect all the studies reporting clinical details of subjects with PPP3CA pathogenic variants within the regulatory domain. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Our in-depth investigation reveals two distinct electro-clinical phenotypes with unique interictal and ictal patterns. Pathogenic variants within the calmodulin-binding domain result in childhood-onset epilepsy with focal and generalized seizures, developmental and intellectual impairments. Pathogenic variants within the regulatory domain lead to early onset drug-resistant severe epilepsy and potentially fatal outcomes. Comparative analysis with existing literature corroborates the notion that truncating mutations, prevalent in the regulatory domain but also possible in the calmodulin-binding domain, consistently associate with more profound disabilities and drug-resistant epilepsy. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Our study emphasizes the critical role of pathogenic variants' type and location on the severity of PPP3CA-related DEE. We also speculate, based on peculiar EEG patterns, on potential pathophysiological mechanisms involving calcineurin dysfunction and calcium homeostasis. In order to improve our understanding of this rare DEE, we need both collaborative efforts to gather larger cohorts and further experimental studies. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcineurin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcineurin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcium-related+epileptogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcium-related epileptogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Developmental+and+epileptic+encephalopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Developmental and epileptic encephalopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug-resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug-resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genotype-phenotype+correlation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genotype-phenotype correlation</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcineurin%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcineurin/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Developmental+Disabilities%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Developmental Disabilities/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Developmental+Disabilities%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Developmental Disabilities/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Developmental+Disabilities%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Developmental Disabilities/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electroencephalography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electroencephalography</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Farach LS</b>, Richard MA, Wulsin AC, Bebin EM, Krueger DA, Sahin M, Porter BE, McPherson TO, Peters JM, O'Kelley S, Taub KS, Rajaraman R, Randle SC, McClintock WM, Koenig MK, Frost MD, Werner K, Nolan DA, Wong M, Cutter G, Northrup H, Au KS. Drug-Resistant Epilepsy in Tuberous Sclerosis Complex Is Associated With TSC2 Genotype: More Findings From the Preventing Epilepsy Using Vigatrin (PREVeNT) Trial. <em class='incite-journal-name' onclick='ShowInCiteJournal(18814);'>Pediatr Neurol</em> 2024;<b>159</b>:62-71. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39142021' target='_blank'>39142021</a> DOI: <a href='https://dx.doi.org/10.1016/j.pediatrneurol.2024.06.012' target='_blank'>10.1016/j.pediatrneurol.2024.06.012</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.pediatrneurol.2024.06.012','39142021', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(6);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.pediatrneurol.2024.06.012' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18814);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/pnu/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.pediatrneurol.2024.06.012" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Children with tuberous sclerosis complex (TSC) are at high risk for drug-resistant epilepsy (DRE). The ability to stratify those at highest risk for DRE is important for counseling and prompt, aggressive management, necessary to optimize neurocognitive outcomes. Using the extensively phenotyped PREVeNT cohort, we aimed to characterize whether the TSC genotype was associated with DRE. </div><div class="abstract-label">METHODS</div><div class="abstract-content">The study group (N = 70) comprised participants with TSC enrolled at age less than or equal to six months with detailed epilepsy and other phenotypic and genotypic data, prospectively collected as part of the PREVeNT trial. Genotype-phenotype correlations of DRE, time to first abnormal electroencephalography, and time to epilepsy onset were compared using Fisher exact test and regression models. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Presence of a TSC2 pathogenic variant was significantly associated with DRE, compared with TSC1 and participants with no pathogenic mutation identified. In fact, all participants with DRE had a TSC2 pathogenic variant. Furthermore, TSC2 variants expected to result in no protein product were associated with higher risk for DRE. Finally, TSC1 pathogenic variants were associated with later-onset epilepsy, on average 21.2 months later than those with other genotypes. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Using a comprehensively phenotyped cohort followed from infancy, this study is the first to delineate genotype-phenotype correlations for epilepsy severity and onset in children with TSC. Patients with TSC2 pathogenic variants, especially TSC2 pathogenic variants predicted to result in lack of TSC2 protein, are at highest risk for DRE, and are likely to have earlier epilepsy onset than those with TSC1. Clinically, these insights can inform counseling, surveillance, and management. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug-resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug-resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tuberous+sclerosis+complex+(TSC)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tuberous sclerosis complex (TSC)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vigabatrin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vigabatrin</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tuberous+Sclerosis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tuberous Sclerosis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tuberous+Sclerosis%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tuberous Sclerosis/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tuberous+Sclerosis+Complex+2+Protein%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tuberous Sclerosis Complex 2 Protein/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tuberous+Sclerosis+Complex+1+Protein%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tuberous Sclerosis Complex 1 Protein/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Association+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Association Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vigabatrin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vigabatrin</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NINDS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">U01 NS092595 NINDS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NINDS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">U54 NS092090 NINDS NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Krygier M</b>, Ziętkiewicz S, Talaśka-Liczbik W, Chylińska M, Walczak A, Kostrzewa G, Płoski R, Mazurkiewicz-Bełdzińska M. The epilepsy phenotype of KCNK4-related neurodevelopmental disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(169208);'>Seizure</em> 2024;<b>121</b>:114-122. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39146707' target='_blank'>39146707</a> DOI: <a href='https://dx.doi.org/10.1016/j.seizure.2024.08.008' target='_blank'>10.1016/j.seizure.2024.08.008</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.seizure.2024.08.008','39146707', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.seizure.2024.08.008' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169208);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/17/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.seizure.2024.08.008" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">INTRODUCTION</div><div class="abstract-content">Potassium ion channels play a crucial role in maintaining cellular electrical stability and are implicated in various epilepsies. Heterozygous pathogenic variants in KCNK4 cause a recognizable neurodevelopmental syndrome with facial dysmorphism, hypertrichosis, epilepsy, intellectual disability (ID), and gingival overgrowth (FHEIG). To date, no more than nine patients with FHEIG have been described worldwide and still little is known about epileptic phenotype in KCNK4-related disease. </div><div class="abstract-label">METHODS</div><div class="abstract-content">We identified a novel de novo p.(Gly139Arg) variant in KCNK4 in a patient with drug-resistant nocturnal seizures, mild ID, and dysmorphic features. In silico analyses of the variant strongly suggest a gain-of-function effect. We conducted a retrospective review of previously published cases, focusing on the epileptic features and response to various treatments. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">To date, epilepsy has been reported in 8/10 patients with KCNK4-related disease. The mean age of seizure onset was 1.8 years, and the most common seizure type was focal to bilateral tonic-clonic (5/8). Sodium channel blockers and valproate were effective in the majority of patients, but in 3/8 the epilepsy was drug-resistant. Our patient showed improved seizure control after treatment with the carbonic anhydrase inhibitor sulthiame. Interestingly, the patient showed features of peripheral nerve hyperexcitability syndrome, a phenomenon not previously described in potassium channelopathies caused by increased K+ conductance. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Gain-of-function variants in KCNK4 cause a spectrum of epilepsies, ranging from benign isolated epilepsy to epileptic encephalopathy, with focal to bilateral tonic-clonic seizures being the most commonly observed. Importantly, a subgroup of patients present with a mild extra-neurological phenotype without characteristic facial dysmorphism or generalized hypertrichosis. This report expands the phenotypic spectrum of KNCK4-associated disease and provides new insights into the clinical heterogeneity of this rare neurodevelopmental syndrome. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Demyelinating+neuropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Demyelinating neuropathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FHEIG%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FHEIG</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gain-of-function%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gain-of-function</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22KCNK4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">KCNK4</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peripheral+nerve+hyperexcitabilty+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peripheral nerve hyperexcitabilty syndrome</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodevelopmental+Disorders%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodevelopmental Disorders/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodevelopmental+Disorders%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodevelopmental Disorders/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intellectual+Disability%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intellectual Disability/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intellectual+Disability%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intellectual Disability/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/physiopathology</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Toral-Rios D</b>, Pichardo-Rojas P, Ruiz-Sánchez E, Rosas-Carrasco Ó, Carvajal-García R, Gálvez-Coutiño DC, Martínez-Rodríguez NL, Rubio-Chávez AD, Alcántara-Flores M, López-Ramírez A, Martínez-Rosas AR, Ruiz-Chow ÁA, Alonso-Vanegas M, Campos-Peña V. Synergistic Effect between the <i>APOE ε4</i> Allele with Genetic Variants of <i>GSK3B</i> and <i>MAPT</i>: Differential Profile between Refractory Epilepsy and Alzheimer Disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2024;<b>25</b>:10228. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39337715' target='_blank'>39337715</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11432663' target='_blank'>PMC11432663</a> DOI: <a href='https://dx.doi.org/10.3390/ijms251810228' target='_blank'>10.3390/ijms251810228</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms251810228','39337715', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms251810228' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/30/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.3390/ijms251810228" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Temporal Lobe Epilepsy (TLE) is a chronic neurological disorder characterized by recurrent focal seizures originating in the temporal lobe. Despite the variety of antiseizure drugs currently available to treat TLE, about 30% of cases continue to have seizures. The etiology of TLE is complex and multifactorial. Increasing evidence indicates that Alzheimer's disease (AD) and drug-resistant TLE present common pathological features that may induce hyperexcitability, especially aberrant hyperphosphorylation of tau protein. Genetic polymorphic variants located in genes of the microtubule-associated protein tau (MAPT) and glycogen synthase kinase-3β (GSK3B) have been associated with the risk of developing AD. The APOE ε4 allele is a major genetic risk factor for AD. Likewise, a gene-dose-dependent effect of ε4 seems to influence TLE. The present study aimed to investigate whether the APOE ɛ4 allele and genetic variants located in the MAPT and GSK3B genes are associated with the risk of developing AD and drug-resistant TLE in a cohort of the Mexican population. A significant association with the APOE ε4 allele was observed in patients with AD and TLE. Additional genetic interactions were identified between this allele and variants of the MAPT and GSK3B genes. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22APOE+%ce%b54+allele%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">APOE ε4 allele</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SNP%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SNP</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug-resistant+Epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug-resistant Epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hippocampal+sclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hippocampal sclerosis</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tau+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tau Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tau+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tau Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycogen+Synthase+Kinase+3+beta%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycogen Synthase Kinase 3 beta/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycogen+Synthase+Kinase+3+beta%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycogen Synthase Kinase 3 beta/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alleles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alleles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apolipoprotein+E4%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apolipoprotein E4/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Predisposition+to+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Predisposition to Disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymorphism%2c+Single+Nucleotide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymorphism, Single Nucleotide</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FONSEC+SSA%2fIMSS%2fISSSTE-CONACYT%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">069899 and 273182 FONSEC SSA/IMSS/ISSSTE-CONACYT</a></li></ul> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Nguyen YTM</b>, Vu BQ, Nguyen DK, Quach NV, Bui LT, Hong J, Bui CB. Genotype-driven therapeutics in DEE and metabolic epilepsy: navigating treatment efficacy and drug resistance. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2024;<b>14</b>:21606. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39285222' target='_blank'>39285222</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11405402' target='_blank'>PMC11405402</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-024-72683-7' target='_blank'>10.1038/s41598-024-72683-7</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-024-72683-7','39285222', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(9);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/a6fc3a547b6d10887a95a322bf1bd4ef/41598_2024_Article_72683.PMC11405402.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1038/s41598-024-72683-7');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/22/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1038/s41598-024-72683-7" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neonatal intensive care unit (NICU), particularly in treating developmental and epileptic encephalopathy (DEE) and metabolic epilepsy (ME), requires a deep understanding of their complex etiologies and treatment responses. After excluding treatable cases such as infectious or autoimmune encephalitis, our focus shifted to a more challenging subgroup of 59 patients for in-depth genetic analysis using exome sequencing (ES). The ES analysis identified 40 genetic abnormalities, significantly including de novo variants. Notably, we found structural variation as duplications in regions 2q24.3, including SCN1A and SCN2A were observed in 7 cases. These genetic variants, impacting ion channels, glucose transport, transcription regulation, and kinases, play a crucial role in determining medication efficacy. More than one-third (34.2%) of patients with DEE had an unfavorable response to anti-seizure medications (ASMs) in the chronic phase. However, since the ketogenic supplementary diet showed a positive effect, more than three-quarters (80%) of these drug-resistant patients improved during a 3-month follow-up. In contrast, the ME had a lower adverse reaction rate of 9.1% (2/22) to specialized medications, yet there were 5 fatalities and 10 cases with unidentified genetic etiologies. This study suggests the potential of categorizing drug-resistant variants and that a ketogenic diet could be beneficial in managing DEE and ME. It also opens new perspectives on the mechanisms of the ketogenic diet on the discovered genetic variants. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clinical+sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clinical sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DEE%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DEE</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug response</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ketogenic+diet%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ketogenic diet</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic epilepsy</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exome+Sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exome Sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%2c+Newborn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant, Newborn</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+Ketogenic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, Ketogenic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticonvulsants%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticonvulsants/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NAV1.1+Voltage-Gated+Sodium+Channel%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NAV1.1 Voltage-Gated Sodium Channel/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NAV1.2+Voltage-Gated+Sodium+Channel%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NAV1.2 Voltage-Gated Sodium Channel/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NAV1.2+Voltage-Gated+Sodium+Channel%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NAV1.2 Voltage-Gated Sodium Channel/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistance%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistance/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+Vietnam+National+Foundation+for+Science+and+Technology+Development+(NAFOSTED)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IZVSZ3.203431 the Vietnam National Foundation for Science and Technology Development (NAFOSTED)</a></li></ul> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Wang J</b>, Wu W, Wan J, Zhan L, Chen Y, Yun F, Ji Y, Suo G, Zheng Y, Shen D, Zhang Q. Preliminary study on the mechanism of SAHA in the treatment of refractory epilepsy induced by GABRG2(F343L) mutation. <em class='incite-journal-name' onclick='ShowInCiteJournal(3279);'>Biochem Pharmacol</em> 2024;<b>227</b>:116449. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39053637' target='_blank'>39053637</a> DOI: <a href='https://dx.doi.org/10.1016/j.bcp.2024.116449' target='_blank'>10.1016/j.bcp.2024.116449</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bcp.2024.116449','39053637', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bcp.2024.116449' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3279);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.bcp.2024.116449" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Mutations in the γ-amino butyric acid type A (GABAA) receptor γ2 subunit gene, GABRG2, have been associated with refractory epilepsy. Increasing evidence indicates that suberoylanilide hydroxamic acid (SAHA), a broad-spectrum histone acetyltransferases (HDACs) inhibitor, can inhibit seizure onset. However, the mechanisms involved remains unknown. The present study aimed to explore the anti-epileptic effect and underlying mechanisms of SAHA in the treatment of refractory epilepsy induced by GABRG2 mutation. In the zebrafish line expressing human mutant GABRG2(F343L), Tg(hGABRG2F343L), SAHA was found to reduce seizure onset, swimming activity, and neuronal activity. In both Tg(hGABRG2F343L) zebrafish and HEK293T cells transfected with GABAA receptor subunits, SAHA could improve the pan-acetylation level and reduce the expression of HDAC1/10. The decreased expressions of GABAA receptor subunits could be rescued by SAHA treatment both in vivo and in vitro, which might be the result of increased gene transcription and protein trafficking. The up-regulated acetylation of histone H3 and H4 as well as Bip expression might be involved in the process. Taken together, our data proved that both histone and non-histone acetylation might contribute to the anti-epileptic effect of SAHA in refractory epilepsy caused by GABRG2(F343L) mutation, demonstrating SAHA as a promising therapeutic agent for refractory epilepsy. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GABA(A)+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GABA(A) receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GABRG2+mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GABRG2 mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histone+deacetylases+(HDACs)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histone deacetylases (HDACs)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Refractory+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Refractory epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Suberoylanilide+hydroxamic+acid+(SAHA)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Suberoylanilide hydroxamic acid (SAHA)</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zebrafish%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zebrafish</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+GABA-A%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, GABA-A/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+GABA-A%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, GABA-A/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HEK293+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HEK293 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vorinostat%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vorinostat/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vorinostat%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vorinostat/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticonvulsants%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticonvulsants/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticonvulsants%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticonvulsants/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histone+Deacetylase+Inhibitors%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histone Deacetylase Inhibitors/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histone+Deacetylase+Inhibitors%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histone Deacetylase Inhibitors/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%2c+Genetically+Modified%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals, Genetically Modified</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Panda PK</b>, Mandal S, Gupta SK, Gupta D, Sharawat IK. Low Glycemic Index Therapy in Drug-Refractory SLC6A1 Gene-Related Myoclonic-Astatic Epilepsy. <em class='incite-journal-name' onclick='ShowInCiteJournal(11021);'>Indian J Pediatr</em> 2024;<b>91</b>:985. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38443714' target='_blank'>38443714</a> DOI: <a href='https://dx.doi.org/10.1007/s12098-024-05089-y' target='_blank'>10.1007/s12098-024-05089-y</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12098-024-05089-y','38443714', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s12098-024-05089-y' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11021);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/ijpe/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/07/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1007/s12098-024-05089-y" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticonvulsants%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticonvulsants/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Myoclonic%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Myoclonic/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Myoclonic%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Myoclonic/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycemic+Index%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycemic Index</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Cui TY</b>, Wu H, Tang CY, Wang XF, Li TF, Zhou J. Surgical outcomes of patients with genetically refractory epilepsy: A systematic review and meta-analysis. <em class='incite-journal-name' onclick='ShowInCiteJournal(169208);'>Seizure</em> 2024;<b>120</b>:124-134. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38959583' target='_blank'>38959583</a> DOI: <a href='https://dx.doi.org/10.1016/j.seizure.2024.06.027' target='_blank'>10.1016/j.seizure.2024.06.027</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.seizure.2024.06.027','38959583', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.seizure.2024.06.027' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169208);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.seizure.2024.06.027" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">To summarize the surgical outcomes of genetically refractory epilepsy and identify prognostic factors for these outcomes. </div><div class="abstract-label">METHODS</div><div class="abstract-content">A literature search of the PubMed, Web of Science, and Embase databases for relevant studies, published between January 1, 2002 and December 31, 2023, was performed using specific search terms. All studies addressing surgical outcomes and follow-up of genetically refractory epilepsy were included. All statistical analyses were performed using STATA software (StataCorp LLC, College Station, TX, USA). This review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, 2020 (i.e., "PRISMA") reporting guidelines. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Of the 3833 studies retrieved, 55 fulfilled the inclusion criteria. Eight studies were eligible for meta-analysis at the study level. Pooled outcomes revealed that 74 % of patients who underwent resective surgery (95 % confidence interval [CI] 0.55-0.89; z = 9.47, p < 0.05) achieved Engel I status at the last follow-up. In the study level analysis, pooled outcomes revealed that 9 % of patients who underwent vagus nerve stimulation achieved seizure-free status (95 % CI 0.00-0.31; z = 1.74, p < 0.05), and 61 % (95 % CI 0.55-0.89; z = 11.96, p < 0.05) achieved a 50 % reduction in seizure frequency at the last follow-up. Fifty-three studies comprising 249 patients were included in an individual-level analysis. Among patients who underwent lesion resection or lobectomy/multilobar resection, 65 % (100/153) achieved Engel I status at the last follow-up. Univariate analysis indicated that female sex, somatic mutations, and presenting with focal seizure symptoms were associated with better prognosis (p < 0.05). Additionally, 75 % (21/28) of patients who underwent hemispherectomy/hemispherotomy achieved Engel I status at the last follow-up. In the individual-level analysis, among patients treated with vagus nerve stimulation, 21 % (10/47) were seizure-free and 64 % (30/47) experienced >50 % reduction in seizure frequency compared with baseline. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Meticulous presurgical evaluation and selection of appropriate surgical procedures can, to a certain extent, effectively control seizures. Therefore, various surgical procedures should be considered when treating patients with genetically refractory epilepsy. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+refractory+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic refractory epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuromodulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuromodulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Surgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Surgery</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurosurgical+Procedures%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurosurgical Procedures</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vagus+Nerve+Stimulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vagus Nerve Stimulation</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Fearns N</b>, Wagner M, Borggräfe I, Kunz M, Rémi J, Vollmar C. Good Outcome of Resective Epilepsy Surgery in a 1-Year-Old Child with Drug-Resistant Focal Epilepsy with a Novel Pathogenic COL4A1 Mutation. <em class='incite-journal-name' onclick='ShowInCiteJournal(17838);'>Neuropediatrics</em> 2024;<b>55</b>:255-259. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38167978' target='_blank'>38167978</a> DOI: <a href='https://dx.doi.org/10.1055/a-2236-7066' target='_blank'>10.1055/a-2236-7066</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1055/a-2236-7066','38167978', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1055/a-2236-7066' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17838);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://mc.manuscriptcentral.com/neuped' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1055/a-2236-7066" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pathogenic variants in COL4A1, encoding the α chain of type IV collagen, have been associated with cerebrovascular pathology as well as malformations of cortical development, thereby causing structural epilepsy. This case illustrates successful resective epilepsy surgery in a 12-month-old girl with left occipital focal cortical dysplasia (FCD) associated with a heterozygous splice-donor variant in COL4A1. She presented with drug-resistant focal epilepsy with daily seizures from the age of 2 months, refractory to several combinations of antiseizure medications, as well as mild right-sided hemiparesis and developmental delay. All presurgical diagnostic modalities, including ictal and interictal electroencephalography, magnetic resonance imaging, and ictal fluorodeoxyglucose positron emission tomography, showed congruent findings, pointing toward one single left occipital epileptogenic zone (EZ). We performed a left occipital lobectomy, using intraoperative electrocorticography to confirm the boundaries of the EZ. After surgery, the patient has remained seizure free, and both cognitive and motor developments have improved. Histopathology of the resected brain tissue showed FCD type Ia. Resective epilepsy surgery can have a very good outcome, also in patients with genetic mutations in COL4A1, constituting a less invasive option than the previously used more radical surgical procedures such as hemispherectomy. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Collagen+Type+IV%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Collagen Type IV/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electroencephalography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electroencephalography</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Garcia‐Uzquiano R</b>, Barcia G, Losito E, Chemaly N, Kaminska A, Desguerre I, Blauwblomme T, Boddaert N, Nabbout R. Genetic testing, another important tool in presurgical evaluation of focal epilepsies in childhood. <em class='incite-journal-name' onclick='ShowInCiteJournal(168119);'>Epilepsia Open</em> 2024;<b>9</b>:1589-1596. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38829689' target='_blank'>38829689</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11296104' target='_blank'>PMC11296104</a> DOI: <a href='https://dx.doi.org/10.1002/epi4.12964' target='_blank'>10.1002/epi4.12964</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/epi4.12964','38829689', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/epi4.12964' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168119);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/07/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1002/epi4.12964" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Epilepsy surgery may be a curative therapy for patients with drug-resistant epilepsies when focal lesions or foci are identified. Genetic testing is not yet routinely included in many presurgical evaluation programs although recent evidence support that finding a germline genetic mutation could help to better delineate the patient candidacy to surgery and provide valuable information on the expected surgery outcome. In this study, we report nine patients presenting drug-resistant focal epilepsy enrolled in presurgical evaluation. We show how the identification of genetic pathogenic variant in epilepsy known genes led to the interruption of the presurgical work-up and ruled out surgery in 7 of them. We observed that the co-existence of some recurrent clinical characteristics as early seizures' onset, frequent precipitating factors including fever, and developmental delay or intellectual disability may be useful markers for germline genetic pathogenic variants. In this group, genetic assessment should be mandatory during presurgical work up, mainly in patients with negative magnetic resonance imaging (MRI) or doubtful structural lesions. The integration of next generation targeted sequencing into the presurgical evaluation can improve the selection of candidates for resective surgery and fosters a personalized medicine approach with a better outcome. PLAINE LANGUAGE ABSTRACT: Genetic testing is not yet systematically included in the pre-surgical assessment of patients with drug-resistant focal epilepsies. In this study, through the description of nine patients, we underline how the integration of genomics into the presurgical work up can help in evaluating the patient candidacy to surgery and provide valuable information on expected surgery outcome. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MRI+negative%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MRI negative</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug%e2%80%90resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug‐resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy+gene+panel%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy gene panel</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy+surgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22focal+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">focal epilepsy</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Testing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Testing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Preoperative+Care%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Preoperative Care</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Hanin A</b>, Zhang L, Huttner AJ, Plu I, Mathon B, Bielle F, Navarro V, Hirsch LJ, Hafler DA. Single-Cell Transcriptomic Analyses of Brain Parenchyma in Patients With New-Onset Refractory Status Epilepticus (NORSE). <em>NEUROLOGY(R) NEUROIMMUNOLOGY & NEUROINFLAMMATION</em> 2024;<b>11</b>:e200259. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38810181' target='_blank'>38810181</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139018' target='_blank'>PMC11139018</a> DOI: <a href='https://dx.doi.org/10.1212/nxi.0000000000200259' target='_blank'>10.1212/nxi.0000000000200259</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1212/nxi.0000000000200259','38810181', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1212/nxi.0000000000200259' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/31/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1212/nxi.0000000000200259" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND AND OBJECTIVES</div><div class="abstract-content">New-onset refractory status epilepticus (NORSE) occurs in previously healthy children or adults, often followed by refractory epilepsy and poor outcomes. The mechanisms that transform a normal brain into an epileptic one capable of seizing for prolonged periods despite treatment remain unclear. Nonetheless, several pieces of evidence suggest that immune dysregulation could contribute to hyperexcitability and modulate NORSE sequelae. </div><div class="abstract-label">METHODS</div><div class="abstract-content">We used single-nucleus RNA sequencing to delineate the composition and phenotypic states of the CNS of 4 patients with NORSE, to better understand the relationship between hyperexcitability and immune disturbances. We compared them with 4 patients with chronic temporal lobe epilepsy (TLE) and 2 controls with no known neurologic disorder. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Patients with NORSE and TLE exhibited a significantly higher proportion of excitatory neurons compared with controls, with no discernible difference in inhibitory GABAergic neurons. When examining the ratio between excitatory neurons and GABAergic neurons for each patient individually, we observed a higher ratio in patients with acute NORSE or TLE compared with controls. Furthermore, a negative correlation was found between the ratio of excitatory to GABAergic neurons and the proportion of GABAergic neurons. The ratio between excitatory neurons and GABAergic neurons correlated with the proportion of resident or infiltrating macrophages, suggesting the influence of microglial reactivity on neuronal excitability. Both patients with NORSE and TLE exhibited increased expression of genes associated with microglia activation, phagocytic activity, and NLRP3 inflammasome activation. However, patients with NORSE had decreased expression of genes related to the downregulation of the inflammatory response, potentially explaining the severity of their presentation. Microglial activation in patients with NORSE also correlated with astrocyte reactivity, possibly leading to higher degrees of demyelination. </div><div class="abstract-label">DISCUSSION</div><div class="abstract-content">Our study sheds light on the complex cellular dynamics in NORSE, revealing the potential roles of microglia, infiltrating macrophages, and astrocytes in hyperexcitability and demyelination, offering potential avenues for future research targeting the identified pathways. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Status+Epilepticus%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Status Epilepticus/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Single-Cell+Analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Single-Cell Analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcriptome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcriptome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GABAergic+Neurons%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GABAergic Neurons/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Profiling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Profiling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Klein KM</b>, Mascarenhas R, Merrikh D, Khanbabaei M, Maroilley T, Kaur N, Liu Y, Soule T, Manalo M, Tamura G, Jacobs J, Hader W, Pfeffer G, Tarailo-Graovac M. Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysplasia using a novel depth electrode harvesting technique. <em class='incite-journal-name' onclick='ShowInCiteJournal(8564);'>Epilepsia</em> 2024;<b>65</b>:1768-1776. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38587282' target='_blank'>38587282</a> DOI: <a href='https://dx.doi.org/10.1111/epi.17980' target='_blank'>10.1111/epi.17980</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/epi.17980','38587282', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(16);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/epi.17980' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8564);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1111/epi.17980" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Recent studies have identified brain somatic variants as a cause of focal epilepsy. These studies relied on resected tissue from epilepsy surgery, which is not available in most patients. The use of trace tissue adherent to depth electrodes used for stereo electroencephalography (EEG) has been proposed as an alternative but is hampered by the low cell quality and contamination by nonbrain cells. Here, we use our improved depth electrode harvesting technique that purifies neuronal nuclei to achieve molecular diagnosis in a patient with focal cortical dysplasia (FCD). </div><div class="abstract-label">METHODS</div><div class="abstract-content">Depth electrode tips were collected, pooled by brain region and seizure onset zone, and nuclei were isolated and sorted using fluorescence-activated nuclei sorting (FANS). Somatic DNA was amplified from neuronal and astrocyte nuclei using primary template amplification followed by exome sequencing of neuronal DNA from the affected pool, unaffected pool, and saliva. The identified variant was validated using droplet digital polymerase chain reaction (PCR). </div><div class="abstract-label">RESULTS</div><div class="abstract-content">An 11-year-old male with drug-resistant genetic-structural epilepsy due to left anterior insula FCD had seizures from age 3 years. Stereo EEG confirmed seizure onset in the left anterior insula. The two anterior insula electrodes were combined as the affected pool and three frontal electrodes as the unaffected pool. FANS isolated 140 neuronal nuclei from the affected and 245 neuronal nuclei from the unaffected pool. A novel somatic missense MTOR variant (p.Leu489Met, CADD score 23.7) was identified in the affected neuronal sample. Droplet digital PCR confirmed a mosaic gradient (variant allele frequency = .78% in affected neuronal sample; variant was absent in all other samples). </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">Our findings confirm that harvesting neuronal DNA from depth electrodes followed by molecular analysis to identify brain somatic variants is feasible. Our novel method represents a significant improvement compared to the previous method by focusing the analysis on high-quality cells of the cell type of interest. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22focal+cortical+dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">focal cortical dysplasia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mosaic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mosaic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22somatic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">somatic</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurons%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurons</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electroencephalography%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electroencephalography/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mosaicism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mosaicism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Focal+Cortical+Dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Focal Cortical Dysplasia</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22+CIHR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"> CIHR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Canada+Foundation+for+Innovation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Canada Foundation for Innovation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy+Canada%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy Canada</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22+CIHR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"> CIHR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Azrieli+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Azrieli Foundation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fondation+Brain+Canada%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fondation Brain Canada</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Health+Canada%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Health Canada</a></li></ul> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Córdoba NM</b>, Lince-Rivera I, Gómez JLR, Rubboli G, De la Rosa SO. ATP1A2-related epileptic encephalopathy and movement disorder: Clinical features of three novel patients. <em class='incite-journal-name' onclick='ShowInCiteJournal(8595);'>Epileptic Disord</em> 2024;<b>26</b>:332-340. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38512072' target='_blank'>38512072</a> DOI: <a href='https://dx.doi.org/10.1002/epd2.20220' target='_blank'>10.1002/epd2.20220</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/epd2.20220','38512072', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/epd2.20220' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8595);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1002/epd2.20220" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Variants in the ATP1A2 gene exhibit a wide clinical spectrum, ranging from familial hemiplegic migraine to childhood epilepsies and early infantile developmental epileptic encephalopathy (EIDEE) with movement disorders. This study aims to describe the epileptology of three unpublished cases and summarize epilepsy features of the other 17 published cases with ATP1A2 variants and EIDEE. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Medical records of three novel patients with pathogenic ATP1A2 variants were retrospectively reviewed. Additionally, the PUBMED, EMBASE, and Cochrane databases were searched until December 2023 for articles on EIDEE with ATP1A2 variants, without language or publication year restrictions. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Three female patients, aged 6 months-10 years, were investigated. Epilepsy onset occurred between 5 days and 2 years, accompanied by severe developmental delay, intellectual disability, drug-resistant epilepsy, severe movement disorder, and recurrent status epilepticus. All individuals had pathogenic variants of the ATP1A2 gene (ATP1A2 c.720_721del (p.Ile240MetfsTer9), ATP1A2c.3022C > T (p.Arg1008Trp), ATP1A2 c.1096G > T (p.Gly366Cys), according to ACMG criteria. Memantine was p) rescribed to three patients, one with a reduction in ictal frequency, one with improvement in gait pattern, coordination, and attention span, and another one in alertness without significant side effects. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">This study reinforces the association between ATP1A2 variants and a severe phenotype. All patients had de novo variants, focal motor seizures with impaired awareness as the primary type of seizure; of the 11 EEGs recorded, 10 presented a slow background rhythm, 7 multifocal interictal epileptiform discharges (IED), predominantly temporal IEDs, followed by frontal IED, as well as ten ictal recordings, which showed ictal onset from the same regions mentioned above. Treatment with antiseizure medication was generally ineffective, but memantine showed moderate improvement. Prospective studies are needed to enlarge the phenotype and assess the efficacy of NMDA receptor antagonist therapies in reducing seizure frequency and improving quality of life. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%5cnATP1A2%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"> ATP1A2 </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NMDA+receptor+antagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NMDA receptor antagonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug%e2%80%90resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug‐resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22encephalopathies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">encephalopathies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genetic+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genetic epilepsy</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sodium-Potassium-Exchanging+ATPase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sodium-Potassium-Exchanging ATPase/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Movement+Disorders%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Movement Disorders/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Movement+Disorders%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Movement Disorders/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Movement+Disorders%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Movement Disorders/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Movement+Disorders%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Movement Disorders/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spasms%2c+Infantile%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spasms, Infantile/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spasms%2c+Infantile%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spasms, Infantile/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spasms%2c+Infantile%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spasms, Infantile/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intellectual+Disability%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intellectual Disability/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intellectual+Disability%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intellectual Disability/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Memantine%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Memantine/therapeutic use</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Kolosky T</b>, Erdemir G. A novel GRIN2B variant (p.F1340V) causes a severe neurodevelopmental disorder with refractory epileptic spasms. <em class='incite-journal-name' onclick='ShowInCiteJournal(8595);'>Epileptic Disord</em> 2024;<b>26</b>:395-397. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38411992' target='_blank'>38411992</a> DOI: <a href='https://dx.doi.org/10.1002/epd2.20210' target='_blank'>10.1002/epd2.20210</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/epd2.20210','38411992', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/epd2.20210' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8595);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/25/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1002/epd2.20210" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+N-Methyl-D-Aspartate%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, N-Methyl-D-Aspartate/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodevelopmental+Disorders%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodevelopmental Disorders/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodevelopmental+Disorders%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodevelopmental Disorders/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spasms%2c+Infantile%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spasms, Infantile/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spasms%2c+Infantile%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spasms, Infantile/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Feroze N</b>, Karim T, Ostojic K, Mcintyre S, Barnes EH, Lee BC, Dale RC, Gill D, Kothur K. Clinical features associated with epilepsy occurrence, resolution, and drug resistance in children with cerebral palsy: A population-based study. <em class='incite-journal-name' onclick='ShowInCiteJournal(7881);'>Dev Med Child Neurol</em> 2024;<b>66</b>:793-803. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38059324' target='_blank'>38059324</a> DOI: <a href='https://dx.doi.org/10.1111/dmcn.15807' target='_blank'>10.1111/dmcn.15807</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1111%2fdmcn.15807%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1111%2fdmcn.15807')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/dmcn.15807','38059324', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(19);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/dmcn.15807' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7881);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://mc.manuscriptcentral.com/dmcn?=' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/08/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/17/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/08/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1111/dmcn.15807" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">AIM</div><div class="abstract-content">To investigate clinicoradiological features associated with epilepsy, its resolution, and drug resistance in children with cerebral palsy (CP). </div><div class="abstract-label">METHOD</div><div class="abstract-content">Data were gathered from the New South Wales/Australian Capital Territory CP Register, encompassing children with CP born between 2003 and 2015 (n = 1916). Clinical features and the severity of impairments were compared among three groups: children with current epilepsy (n = 604), those with resolved epilepsy by age 5 years (n = 109), and those without epilepsy (n = 1203). Additionally, a subset of the registry cohort attending Children's Hospital Westmead (n = 256) was analysed to compare epilepsy and treatment characteristics between drug-responsive (n = 83) and drug-resistant groups (n = 147) using logistic regression and hierarchical cluster analysis. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Manual Ability Classification System levels IV and V, intellectual impairment, and vision impairment were found to be associated with epilepsy in children with CP on multivariable analysis (p < 0.01). Moderate to severe intellectual impairment and bilateral spastic CP were independent positive and negative predictors of epilepsy persistence at the age of 5 years respectively (p < 0.05). Microcephaly and multiple seizure types were predictors of drug-resistant epilepsy (area under the receiver operating characteristic curve of 0.83; 95% confidence interval 0.77-0.9). Children with a known genetic cause (14%) and CP epilepsy surgery group (4.3%) formed specific clinical subgroups in CP epilepsy. </div><div class="abstract-label">INTERPRETATION</div><div class="abstract-content">Our study highlights important clinical associations of epilepsy, its resolution, and treatment response in children with CP, providing valuable knowledge to aid in counselling families and identifying distinct prognostic groups for effective medical surveillance and optimal treatment. </div><div class="abstract-label">WHAT THIS PAPER ADDS</div><div class="abstract-content">Severe motor and non-motor impairments in cerebral palsy (CP) increase epilepsy risk. Epilepsy more likely resolves in bilateral spastic and milder CP impairments. Epilepsy in CP often manifests at an early age with multiple seizure types and high drug resistance. Children with a known genetic cause and CP epilepsy surgery group represent distinct clinical subgroups. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Palsy%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Palsy/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intellectual+Disability%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intellectual Disability</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticonvulsants%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticonvulsants/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Registries%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Registries</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22New+South+Wales%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">New South Wales/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Severity+of+Illness+Index%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Severity of Illness Index</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vision+Disorders%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vision Disorders/etiology</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Palsy+Alliance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PG01418 Cerebral Palsy Alliance</a></li></ul> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Zhang K</b>, Yao H, Yang J, Jia T, Shan Q, Li D, Li M, Gan L, Wang X, Dong Y. Analysis of clinical characteristics and histopathological transcription in 40 patients afflicted by epilepsy stemming from focal cortical dysplasia. <em class='incite-journal-name' onclick='ShowInCiteJournal(168119);'>Epilepsia Open</em> 2024;<b>9</b>:981-995. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38491953' target='_blank'>38491953</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11145614' target='_blank'>PMC11145614</a> DOI: <a href='https://dx.doi.org/10.1002/epi4.12928' target='_blank'>10.1002/epi4.12928</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/epi4.12928','38491953', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/epi4.12928' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168119);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/05/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/18/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1002/epi4.12928" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">This study aims to comprehensively analyze the clinical characteristics and identify the differentially expressed genes associated with drug-resistant epilepsy (DRE) in patients with focal cortical dysplasia (FCD). </div><div class="abstract-label">METHODS</div><div class="abstract-content">A retrospective investigation was conducted from July 2019 to June 2022, involving 40 pediatric cases of DRE linked to FCD. Subsequent follow-ups were done to assess post-surgical outcomes. Transcriptomic sequencing and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used to examine differential gene expression between the FCD and control groups. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Among the 40 patients included in the study, focal to bilateral tonic-clonic seizures (13/40, 32.50%) and epileptic spasms (9/40, 22.50%) were the predominant seizure types. Magnetic resonance imaging (MRI) showed frequent involvement of the frontal (22/40, 55%) and temporal lobes (12/40, 30%). In cases with negative MRI results (13/13, 100%), positron emission tomography/computed tomography (PET-CT) scans revealed hypometabolic lesions. Fused MRI/PET-CT images demonstrated lesion reduction in 40.74% (11/27) of cases compared with PET-CT alone, while 59.26% (16/27) yielded results consistent with PET-CT findings. FCD type II was identified in 26 cases, and FCD type I in 13 cases. At the last follow-up, 38 patients were prescribed an average of 1.27 ± 1.05 anti-seizure medications (ASMs), with two patients discontinuing treatment. After a postoperative follow-up period of 23.50 months, 75% (30/40) of patients achieved Engel class I outcome. Transcriptomic sequencing and qRT-PCR analysis identified several genes primarily associated with cilia, including CFAP47, CFAP126, JHY, RSPH4A, and SPAG1. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">This study highlights focal to bilateral tonic-clonic seizures as the most common seizure type in patients with DRE due to FCD. Surgical intervention primarily targeted lesions in the frontal and temporal lobes. Patients with FCD-related DRE showed a promising prognosis for seizure control post-surgery. The identified genes, including CFAP47, CFAP126, JHY, RSPH4A, and SPAG1, could serve as potential biomarkers for FCD. </div><div class="abstract-label">PLAIN LANGUAGE SUMMARY</div><div class="abstract-content">This study aimed to comprehensively evaluate the clinical data of individuals affected by focal cortical dysplasia and analyze transcriptomic data from brain tissues. We found that focal to bilateral tonic-clonic seizures were the most prevalent seizure type in patients with drug-resistant epilepsy. In cases treated surgically, the frontal and temporal lobes were the primary sites of the lesions. Moreover, patients with focal cortical dysplasia-induced drug-resistant epilepsy exhibited a favorable prognosis for seizure control after surgery. CFAP47, CFAP126, JHY, RSPH4A, and SPAG1 have emerged as potential pathogenic genes for the development of focal cortical dysplasia. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biomarker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22clinical+features%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">clinical features</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug%e2%80%90refractory+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug‐refractory epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22focal+cortical+dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">focal cortical dysplasia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22transcriptome+sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">transcriptome sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Positron+Emission+Tomography+Computed+Tomography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Positron Emission Tomography Computed Tomography</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Focal+Cortical+Dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Focal Cortical Dysplasia</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Babunovska M</b>, Cepreganova Cangovska T, Kuzmanovski I, Noveski P, Plaseska-Karanfilska D, Cvetkovska E. Novel Variant ANKRD11 Gene Mutation Associated With Drug-Resistant Epilepsy in KBG Syndrome Phenotype. <em class='incite-journal-name' onclick='ShowInCiteJournal(18814);'>Pediatr Neurol</em> 2024;<b>155</b>:51-54. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38593730' target='_blank'>38593730</a> DOI: <a href='https://dx.doi.org/10.1016/j.pediatrneurol.2024.03.011' target='_blank'>10.1016/j.pediatrneurol.2024.03.011</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.pediatrneurol.2024.03.011','38593730', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.pediatrneurol.2024.03.011' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18814);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/pnu/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/30/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1016/j.pediatrneurol.2024.03.011" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ANKRD11+gene+mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ANKRD11 gene mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Combined+generalized+and+focal+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Combined generalized and focal epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug-resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug-resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22KBG+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">KBG syndrome</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Repressor+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Repressor Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intellectual+Disability%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intellectual Disability/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Facies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Facies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Abnormalities%2c+Multiple%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Abnormalities, Multiple/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Diseases%2c+Developmental%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Diseases, Developmental/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Megalencephaly%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Megalencephaly/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tooth+Abnormalities%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tooth Abnormalities</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Buainain RP</b>, Sodré AR, dos Santos JS, Takazaki KAG, Queiroz LDS, de Oliveira CTP, de Aguiar PHP, Marson FAL, Ortega MM. Single-Base Gene Variants in <i>MIR-146A</i> and <i>SCN1A</i> Genes Related to the Epileptogenic Process in Drug-Responsive and Drug-Resistant Temporal Lobe Epilepsy-A Preliminary Study in a Brazilian Cohort Sample. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2024;<b>25</b>:6005. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38892194' target='_blank'>38892194</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172889' target='_blank'>PMC11172889</a> DOI: <a href='https://dx.doi.org/10.3390/ijms25116005' target='_blank'>10.3390/ijms25116005</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms25116005','38892194', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(22);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms25116005' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/21/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.3390/ijms25116005" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The drug-resistant temporal lobe epilepsy (TLE) has recently been associated with single nucleotide variants (SNVs) in microRNA(miR)-146a (MIR-146A) (rs2910164) and Sodium Voltage-Gated Channel Alpha Subunit 1 (SCN1A) (rs2298771 and rs3812718) genes. Moreover, no studies have shown an association between these SNVs and susceptibility to drug-resistant and drug-responsive TLE in Brazil. Thus, deoxyribonucleic acid (DNA) samples from 120 patients with TLE (55 drug-responsive and 65 drug-resistant) were evaluated by real-time polymerase chain reaction (RT-PCR). A total of 1171 healthy blood donor individuals from the Online Archive of Brazilian Mutations (ABraOM, from Portuguese Arquivo Brasileiro On-line de Mutações), a repository containing genomic variants of the Brazilian population, were added as a control population for the studied SNVs. MIR-146A and SCN1A relative expression was performed by quantitative RT-PCR (qRT-PCR). The statistical analysis protocol was performed using an alpha error of 0.05. TLE patient samples and ABraOM control samples were in Hardy-Weinberg equilibrium for all studied SNVs. For rs2910164, the frequencies of the homozygous genotype (CC) (15.00% vs. 9.65%) and C allele (37.80% vs. 29.97%) were superior in patients with TLE compared to controls with a higher risk for TLE disease [odds ratio (OR) = 1.89 (95% confidence interval (95%CI) = 1.06-3.37); OR = 1.38 (95%CI = 1.04-1.82), respectively]. Drug-responsive patients also presented higher frequencies of the CC genotype [21.81% vs. 9.65%; OR = 2.58 (95%CI = 1.25-5.30)] and C allele [39.09% vs. 29.97%; OR = 1.50 (95%CI = 1.01-2.22)] compared to controls. For rs2298771, the frequency of the heterozygous genotype (AG) (51.67% vs. 40.40%) was superior in patients with TLE compared to controls with a higher risk for TLE disease [OR = 2.42 (95%CI = 1.08-5.41)]. Drug-resistant patients presented a higher AG frequency [56.92% vs. 40.40%; OR = 3.36 (95%CI = 1.04-17.30)] compared to the control group. For rs3812718, the prevalence of genotypes and alleles were similar in both studied groups. The MIR-146A relative expression level was lower in drug-resistant compared to drug-responsive patients for GC (1.6 vs. 0.1, p-value = 0.049) and CC (1.8 vs. 0.6, p-value = 0.039). Also, the SCN1A relative expression levels in samples from TLE patients were significantly higher in AG [2.09 vs. 1.10, p-value = 0.038] and GG (3.19 vs. 1.10, p-value < 0.001) compared to the AA genotype. In conclusion, the rs2910164-CC and rs2298771-AG genotypes are exerting significant risk influence, respectively, on responsive disease and resistant disease, probably due to an upregulated nuclear factor kappa B (NF-kB) and SCN1A loss of function. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MIR-146a+gene%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MIR-146a gene</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SCN1A+gene%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SCN1A gene</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug-resistant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug-resistant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug-responsive%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug-responsive</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22single+nucleotide+variant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">single nucleotide variant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22temporal+lobe+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">temporal lobe epilepsy</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NAV1.1+Voltage-Gated+Sodium+Channel%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NAV1.1 Voltage-Gated Sodium Channel/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymorphism%2c+Single+Nucleotide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymorphism, Single Nucleotide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brazil%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brazil</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Predisposition+to+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Predisposition to Disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cohort+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cohort Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alleles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alleles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Frequency%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Frequency</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Case-Control+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Case-Control Studies</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Council+for+Scientific+and+Technological+Development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">100050/2023-9 National Council for Scientific and Technological Development</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coordination+of+Superior+Level+Staff+Improvement+(CAPES)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">88887464813/2019-00 Coordination of Superior Level Staff Improvement (CAPES)</a></li></ul> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Fu YJ</b>, Piao YS. [Advances of pathological research and classification in malformations of cortical development associated with refractory epilepsy]. <em>ZHONGHUA BING LI XUE ZA ZHI = CHINESE JOURNAL OF PATHOLOGY</em> 2024;<b>53</b>:419-424. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38678320' target='_blank'>38678320</a> DOI: <a href='https://dx.doi.org/10.3760/cma.j.cn112151-20240304-00147' target='_blank'>10.3760/cma.j.cn112151-20240304-00147</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3760/cma.j.cn112151-20240304-00147','38678320', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(23);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/29/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.3760/cma.j.cn112151-20240304-00147" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">With rapid development of genetic testing techniques, neuroimaging and neuroelectrophysiological technologies, our understanding of malformations of cortical development continues to be deepened and updated. In particular, mutations in genes related to the mammalian target of rapamycin (mTOR) signaling pathway have been successively discovered in focal cortical dysplasia (FCD). At the same time, the classification consensus on FCD issued by the International League Against Epilepsy (ILAE) in 2011 has encountered problems and challenges in diagnostic practice. Therefore, in 2022, ILAE proposed an updated version of the FCD classification based on the progress in molecular genetics over the past decade. The main addition to the classification system is "white matter lesions, " and it is also suggested to integrate histopathological, neuroimaging, and molecular testing results for multi-level integrated diagnosis to achieve reliable, clinically relevant, and therapeutic targeted final diagnosis. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Cortex%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Cortex/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Cortex%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Cortex/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Cortex%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Cortex/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22White+Matter%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">White Matter/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22White+Matter%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">White Matter/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroimaging%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroimaging/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Beijing+Natural+Science+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">7242070 Beijing Natural Science Foundation</a></li></ul> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Carton RJ</b>, Doyle MG, Kearney H, Steward CA, Lench NJ, Rogers A, Heinzen EL, McDonald S, Fay J, Lacey A, Beausang A, Cryan J, Brett F, El-Naggar H, Widdess-Walsh P, Costello D, Kilbride R, Doherty CP, Sweeney KJ, O'Brien DF, Henshall DC, Delanty N, Cavalleri GL, Benson KA. Somatic variants as a cause of drug-resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(8564);'>Epilepsia</em> 2024;<b>65</b>:1451-1461. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38491957' target='_blank'>38491957</a> DOI: <a href='https://dx.doi.org/10.1111/epi.17943' target='_blank'>10.1111/epi.17943</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/epi.17943','38491957', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/epi.17943' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8564);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/29/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/18/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1111/epi.17943" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">The contribution of somatic variants to epilepsy has recently been demonstrated, particularly in the etiology of malformations of cortical development. The aim of this study was to determine the diagnostic yield of somatic variants in genes that have been previously associated with a somatic or germline epilepsy model, ascertained from resected brain tissue from patients with multidrug-resistant focal epilepsy. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Forty-two patients were recruited across three categories: (1) malformations of cortical development, (2) mesial temporal lobe epilepsy with hippocampal sclerosis, and (3) nonlesional focal epilepsy. Participants were subdivided based on histopathology of the resected brain. Paired blood- and brain-derived DNA samples were sequenced using high-coverage targeted next generation sequencing to high depth (585× and 1360×, respectively). Variants were identified using Genome Analysis ToolKit (GATK4) MuTect-2 and confirmed using high-coverage Amplicon-EZ sequencing. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Sequence data on 41 patients passed quality control. Four somatic variants were validated following amplicon sequencing: within CBL, ALG13, MTOR, and FLNA. The diagnostic yield across 41 patients was 10%, 9% in mesial temporal lobe epilepsy with hippocampal sclerosis and 20% in malformations of cortical development. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">This study provides novel insights into the etiology of mesial temporal lobe epilepsy with hippocampal sclerosis, highlighting a potential pathogenic role of somatic variants in CBL and ALG13. We also report candidate diagnostic somatic variants in FLNA in focal cortical dysplasia, while providing further insight into the importance of MTOR and related genes in focal cortical dysplasia. This work demonstrates the potential molecular diagnostic value of variants in both germline and somatic epilepsy genes. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug%e2%80%90resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug‐resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mesial+temporal+lobe+epilepsy+with+hippocampal+sclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mesial temporal lobe epilepsy with hippocampal sclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22somatic+variants%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">somatic variants</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Filamins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Filamins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Variation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Variation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampal+Sclerosis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampal Sclerosis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampal+Sclerosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampal Sclerosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+Foundation+Ireland%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">16/RC/3948 Science Foundation Ireland</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Alsubhi S</b>, Berrahmoune S, Dudley RWR, Dufresne D, Simard Tremblay E, Srour M, Myers KA. Utility of genetic testing in the pre-surgical evaluation of children with drug-resistant epilepsy. <em class='incite-journal-name' onclick='ShowInCiteJournal(14710);'>J Neurol</em> 2024;<b>271</b>:2503-2508. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38261030' target='_blank'>38261030</a> DOI: <a href='https://dx.doi.org/10.1007/s00415-023-12174-3' target='_blank'>10.1007/s00415-023-12174-3</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00415-023-12174-3','38261030', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(25);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00415-023-12174-3' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14710);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/27/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/24/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1007/s00415-023-12174-3" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">We evaluated the utility of genetic testing in the pre-surgical evaluation of pediatric patients with drug-resistant focal epilepsy. This single-center retrospective study reviewed the charts of all pediatric patients referred for epilepsy surgery evaluation over a 5-year period. We extracted and analyzed results of genetic testing as well as clinical, EEG, and neuroimaging data. Of 125 patients referred for epilepsy surgical evaluation, 86 (69%) had some form of genetic testing. Of these, 18 (21%) had a pathogenic or likely pathogenic variant identified. Genes affected included NPRL3 (3 patients, all related), TSC2 (3 patients), KCNH1, CHRNA4, SPTAN1, DEPDC5, SCN2A, ARX, SCN1A, DLG4, and ST5. One patient had ring chromosome 20, one a 7.17p12 duplication, and one a 15q13 deletion. In six patients, suspected epileptogenic lesions were identified on brain MRI that were thought to be unrelated to the genetic finding. A specific medical therapy choice was allowed due to genetic diagnosis in three patients who did not undergo surgery. Obtaining a molecular diagnosis may dramatically alter management in pediatric patients with drug-resistant focal epilepsy. Genetic testing should be incorporated as part of standard investigations in the pre-surgical work-up of pediatric patients with drug-resistant focal epilepsy. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CHRNA4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CHRNA4</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug-resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug-resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy+surgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+testing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic testing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NPRL3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NPRL3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SCN2A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SCN2A</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Testing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Testing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electroencephalography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electroencephalography</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Preoperative+Care%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Preoperative Care</a></li></ul> <a href="javascript:ShowArticleMeSH(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fonds+de+Recherche+du+Qu%c3%a9bec+-+Sant%c3%a9%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">282228 Fonds de Recherche du Québec - Santé</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fonds+de+Recherche+du+Qu%c3%a9bec+-+Sant%c3%a9%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">295639 Fonds de Recherche du Québec - Santé</a></li></ul> <a href="javascript:ShowArticleGrant(25);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> </tbody></table> <div class="search-pager-container"> <div class="dxpLite_MetropolisBlue" id="RootHolder_SearchResultPager" style="margin-top: 20px; margin-bottom: 20px;"> <b class="dxp-lead dxp-button dxp-bi dxp-disabledButton"><img class="dxWeb_pPrevDisabled_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Prev" /></b><b class="dxp-summary" style="margin-left:0px;">Page 1 of 4 </b><b class="dxp-num dxp-current page-number" style="margin-left:0px;">1</b><a class="dxp-num page-number" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">2</a><a class="dxp-num page-number" href="/Search?page=3&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">3</a><a class="dxp-num page-number" href="/Search?page=4&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">4</a><a class="dxp-button dxp-bi" onclick="ASPx.PGNav(event);" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;"><img class="dxWeb_pNext_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Next" /></a> </div><b class="dx-clear"></b><script id="dxss_1137877684" type="text/javascript">  </script> </div> </div> <div class="cl"></div> </div> </div> </div> <table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="RootHolder_LeftLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="text-align:Center;vertical-align:Top;"><span id="RootHolder_LeftLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="RootHolder_LeftLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1950550554" type="text/javascript">  </script> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleCitationPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleCitationPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1115091042" type="text/javascript">  </script> <div id="RootHolder_chartPopupControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Drug Resistant Epilepsy/genetics (89 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="89" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Drug Resistant Epilepsy/genetics (89 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="89" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>