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<table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">104</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (11)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (37)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div 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Single-Cell Transcriptomic Analyses of Brain Parenchyma in Patients With New-Onset Refractory Status Epilepticus (NORSE). <em>NEUROLOGY(R) NEUROIMMUNOLOGY & NEUROINFLAMMATION</em> 2024;<b>11</b>:e200259. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38810181' target='_blank'>38810181</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139018' target='_blank'>PMC11139018</a> DOI: <a href='https://dx.doi.org/10.1212/nxi.0000000000200259' target='_blank'>10.1212/nxi.0000000000200259</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1212/nxi.0000000000200259','38810181', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(26);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(26);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(26);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1212/nxi.0000000000200259' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/31/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv26" value="10.1212/nxi.0000000000200259" /> <div style="display: none" id="articleAbstract26" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND AND OBJECTIVES</div><div class="abstract-content">New-onset refractory status epilepticus (NORSE) occurs in previously healthy children or adults, often followed by refractory epilepsy and poor outcomes. The mechanisms that transform a normal brain into an epileptic one capable of seizing for prolonged periods despite treatment remain unclear. Nonetheless, several pieces of evidence suggest that immune dysregulation could contribute to hyperexcitability and modulate NORSE sequelae. </div><div class="abstract-label">METHODS</div><div class="abstract-content">We used single-nucleus RNA sequencing to delineate the composition and phenotypic states of the CNS of 4 patients with NORSE, to better understand the relationship between hyperexcitability and immune disturbances. We compared them with 4 patients with chronic temporal lobe epilepsy (TLE) and 2 controls with no known neurologic disorder. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Patients with NORSE and TLE exhibited a significantly higher proportion of excitatory neurons compared with controls, with no discernible difference in inhibitory GABAergic neurons. When examining the ratio between excitatory neurons and GABAergic neurons for each patient individually, we observed a higher ratio in patients with acute NORSE or TLE compared with controls. Furthermore, a negative correlation was found between the ratio of excitatory to GABAergic neurons and the proportion of GABAergic neurons. The ratio between excitatory neurons and GABAergic neurons correlated with the proportion of resident or infiltrating macrophages, suggesting the influence of microglial reactivity on neuronal excitability. Both patients with NORSE and TLE exhibited increased expression of genes associated with microglia activation, phagocytic activity, and NLRP3 inflammasome activation. However, patients with NORSE had decreased expression of genes related to the downregulation of the inflammatory response, potentially explaining the severity of their presentation. Microglial activation in patients with NORSE also correlated with astrocyte reactivity, possibly leading to higher degrees of demyelination. </div><div class="abstract-label">DISCUSSION</div><div class="abstract-content">Our study sheds light on the complex cellular dynamics in NORSE, revealing the potential roles of microglia, infiltrating macrophages, and astrocytes in hyperexcitability and demyelination, offering potential avenues for future research targeting the identified pathways. </div> <a href="javascript:ShowArticleAbstract(26);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords26" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(26);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh26" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R56 AG074015 NIA NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(26);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow27"> <td style="min-width: 40px; text-align: center;"> 27 </td> <td> <div id="citation27" class="article-citation"> <b>Klein KM</b>, Mascarenhas R, Merrikh D, Khanbabaei M, Maroilley T, Kaur N, Liu Y, Soule T, Manalo M, Tamura G, Jacobs J, Hader W, Pfeffer G, Tarailo-Graovac M. Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysplasia using a novel depth electrode harvesting technique. <em class='incite-journal-name' onclick='ShowInCiteJournal(8564);'>Epilepsia</em> 2024;<b>65</b>:1768-1776. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38587282' target='_blank'>38587282</a> DOI: <a href='https://dx.doi.org/10.1111/epi.17980' target='_blank'>10.1111/epi.17980</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/epi.17980','38587282', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(27);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(27);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(27);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(27);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/epi.17980' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8564);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv27" value="10.1111/epi.17980" /> <div style="display: none" id="articleAbstract27" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Recent studies have identified brain somatic variants as a cause of focal epilepsy. These studies relied on resected tissue from epilepsy surgery, which is not available in most patients. The use of trace tissue adherent to depth electrodes used for stereo electroencephalography (EEG) has been proposed as an alternative but is hampered by the low cell quality and contamination by nonbrain cells. Here, we use our improved depth electrode harvesting technique that purifies neuronal nuclei to achieve molecular diagnosis in a patient with focal cortical dysplasia (FCD). </div><div class="abstract-label">METHODS</div><div class="abstract-content">Depth electrode tips were collected, pooled by brain region and seizure onset zone, and nuclei were isolated and sorted using fluorescence-activated nuclei sorting (FANS). Somatic DNA was amplified from neuronal and astrocyte nuclei using primary template amplification followed by exome sequencing of neuronal DNA from the affected pool, unaffected pool, and saliva. The identified variant was validated using droplet digital polymerase chain reaction (PCR). </div><div class="abstract-label">RESULTS</div><div class="abstract-content">An 11-year-old male with drug-resistant genetic-structural epilepsy due to left anterior insula FCD had seizures from age 3 years. Stereo EEG confirmed seizure onset in the left anterior insula. The two anterior insula electrodes were combined as the affected pool and three frontal electrodes as the unaffected pool. FANS isolated 140 neuronal nuclei from the affected and 245 neuronal nuclei from the unaffected pool. A novel somatic missense MTOR variant (p.Leu489Met, CADD score 23.7) was identified in the affected neuronal sample. Droplet digital PCR confirmed a mosaic gradient (variant allele frequency = .78% in affected neuronal sample; variant was absent in all other samples). </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">Our findings confirm that harvesting neuronal DNA from depth electrodes followed by molecular analysis to identify brain somatic variants is feasible. Our novel method represents a significant improvement compared to the previous method by focusing the analysis on high-quality cells of the cell type of interest. </div> <a href="javascript:ShowArticleAbstract(27);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords27" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22focal+cortical+dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">focal cortical dysplasia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mosaic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mosaic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22somatic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">somatic</a></li></ul> <a href="javascript:ShowArticleKeywords(27);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh27" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurons%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurons</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electroencephalography%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electroencephalography/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mosaicism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mosaicism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Focal+Cortical+Dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Focal Cortical Dysplasia</a></li></ul> <a href="javascript:ShowArticleMeSH(27);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant27" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22+CIHR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"> CIHR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Canada+Foundation+for+Innovation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Canada Foundation for Innovation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy+Canada%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy Canada</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22+CIHR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"> CIHR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Azrieli+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Azrieli Foundation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fondation+Brain+Canada%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fondation Brain Canada</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Health+Canada%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Health Canada</a></li></ul> <a href="javascript:ShowArticleGrant(27);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow28"> <td style="min-width: 40px; text-align: center;"> 28 </td> <td> <div id="citation28" class="article-citation"> <b>Córdoba NM</b>, Lince-Rivera I, Gómez JLR, Rubboli G, De la Rosa SO. ATP1A2-related epileptic encephalopathy and movement disorder: Clinical features of three novel patients. <em class='incite-journal-name' onclick='ShowInCiteJournal(8595);'>Epileptic Disord</em> 2024;<b>26</b>:332-340. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38512072' target='_blank'>38512072</a> DOI: <a href='https://dx.doi.org/10.1002/epd2.20220' target='_blank'>10.1002/epd2.20220</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/epd2.20220','38512072', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(28);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(28);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(28);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/epd2.20220' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8595);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv28" value="10.1002/epd2.20220" /> <div style="display: none" id="articleAbstract28" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Variants in the ATP1A2 gene exhibit a wide clinical spectrum, ranging from familial hemiplegic migraine to childhood epilepsies and early infantile developmental epileptic encephalopathy (EIDEE) with movement disorders. This study aims to describe the epileptology of three unpublished cases and summarize epilepsy features of the other 17 published cases with ATP1A2 variants and EIDEE. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Medical records of three novel patients with pathogenic ATP1A2 variants were retrospectively reviewed. Additionally, the PUBMED, EMBASE, and Cochrane databases were searched until December 2023 for articles on EIDEE with ATP1A2 variants, without language or publication year restrictions. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Three female patients, aged 6 months-10 years, were investigated. Epilepsy onset occurred between 5 days and 2 years, accompanied by severe developmental delay, intellectual disability, drug-resistant epilepsy, severe movement disorder, and recurrent status epilepticus. All individuals had pathogenic variants of the ATP1A2 gene (ATP1A2 c.720_721del (p.Ile240MetfsTer9), ATP1A2c.3022C > T (p.Arg1008Trp), ATP1A2 c.1096G > T (p.Gly366Cys), according to ACMG criteria. Memantine was p) rescribed to three patients, one with a reduction in ictal frequency, one with improvement in gait pattern, coordination, and attention span, and another one in alertness without significant side effects. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">This study reinforces the association between ATP1A2 variants and a severe phenotype. All patients had de novo variants, focal motor seizures with impaired awareness as the primary type of seizure; of the 11 EEGs recorded, 10 presented a slow background rhythm, 7 multifocal interictal epileptiform discharges (IED), predominantly temporal IEDs, followed by frontal IED, as well as ten ictal recordings, which showed ictal onset from the same regions mentioned above. Treatment with antiseizure medication was generally ineffective, but memantine showed moderate improvement. Prospective studies are needed to enlarge the phenotype and assess the efficacy of NMDA receptor antagonist therapies in reducing seizure frequency and improving quality of life. </div> <a href="javascript:ShowArticleAbstract(28);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords28" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%5cnATP1A2%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"> ATP1A2 </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NMDA+receptor+antagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NMDA receptor antagonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug%e2%80%90resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug‐resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22encephalopathies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">encephalopathies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genetic+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genetic epilepsy</a></li></ul> <a href="javascript:ShowArticleKeywords(28);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh28" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sodium-Potassium-Exchanging+ATPase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sodium-Potassium-Exchanging ATPase/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a 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target="_blank">Memantine/therapeutic use</a></li></ul> <a href="javascript:ShowArticleMeSH(28);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant28" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(28);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow29"> <td style="min-width: 40px; text-align: center;"> 29 </td> <td> <div id="citation29" class="article-citation"> <b>Kolosky T</b>, Erdemir G. A novel GRIN2B variant (p.F1340V) causes a severe neurodevelopmental disorder with refractory epileptic spasms. <em class='incite-journal-name' onclick='ShowInCiteJournal(8595);'>Epileptic Disord</em> 2024;<b>26</b>:395-397. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38411992' target='_blank'>38411992</a> DOI: <a href='https://dx.doi.org/10.1002/epd2.20210' target='_blank'>10.1002/epd2.20210</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/epd2.20210','38411992', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(29);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/epd2.20210' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8595);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/25/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv29" value="10.1002/epd2.20210" /> <div style="display: none" id="articleAbstract29" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(29);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords29" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(29);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh29" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+N-Methyl-D-Aspartate%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, N-Methyl-D-Aspartate/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodevelopmental+Disorders%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodevelopmental Disorders/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodevelopmental+Disorders%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodevelopmental Disorders/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spasms%2c+Infantile%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spasms, Infantile/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spasms%2c+Infantile%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spasms, Infantile/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li></ul> <a href="javascript:ShowArticleMeSH(29);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant29" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(29);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow30"> <td style="min-width: 40px; text-align: center;"> 30 </td> <td> <div id="citation30" class="article-citation"> <b>Feroze N</b>, Karim T, Ostojic K, Mcintyre S, Barnes EH, Lee BC, Dale RC, Gill D, Kothur K. Clinical features associated with epilepsy occurrence, resolution, and drug resistance in children with cerebral palsy: A population-based study. <em class='incite-journal-name' onclick='ShowInCiteJournal(7881);'>Dev Med Child Neurol</em> 2024;<b>66</b>:793-803. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38059324' target='_blank'>38059324</a> DOI: <a href='https://dx.doi.org/10.1111/dmcn.15807' target='_blank'>10.1111/dmcn.15807</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1111%2fdmcn.15807%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1111%2fdmcn.15807')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/dmcn.15807','38059324', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(30);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(30);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(30);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/dmcn.15807' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7881);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://mc.manuscriptcentral.com/dmcn?=' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/08/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/17/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/08/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv30" value="10.1111/dmcn.15807" /> <div style="display: none" id="articleAbstract30" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">AIM</div><div class="abstract-content">To investigate clinicoradiological features associated with epilepsy, its resolution, and drug resistance in children with cerebral palsy (CP). </div><div class="abstract-label">METHOD</div><div class="abstract-content">Data were gathered from the New South Wales/Australian Capital Territory CP Register, encompassing children with CP born between 2003 and 2015 (n = 1916). Clinical features and the severity of impairments were compared among three groups: children with current epilepsy (n = 604), those with resolved epilepsy by age 5 years (n = 109), and those without epilepsy (n = 1203). Additionally, a subset of the registry cohort attending Children's Hospital Westmead (n = 256) was analysed to compare epilepsy and treatment characteristics between drug-responsive (n = 83) and drug-resistant groups (n = 147) using logistic regression and hierarchical cluster analysis. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Manual Ability Classification System levels IV and V, intellectual impairment, and vision impairment were found to be associated with epilepsy in children with CP on multivariable analysis (p < 0.01). Moderate to severe intellectual impairment and bilateral spastic CP were independent positive and negative predictors of epilepsy persistence at the age of 5 years respectively (p < 0.05). Microcephaly and multiple seizure types were predictors of drug-resistant epilepsy (area under the receiver operating characteristic curve of 0.83; 95% confidence interval 0.77-0.9). Children with a known genetic cause (14%) and CP epilepsy surgery group (4.3%) formed specific clinical subgroups in CP epilepsy. </div><div class="abstract-label">INTERPRETATION</div><div class="abstract-content">Our study highlights important clinical associations of epilepsy, its resolution, and treatment response in children with CP, providing valuable knowledge to aid in counselling families and identifying distinct prognostic groups for effective medical surveillance and optimal treatment. </div><div class="abstract-label">WHAT THIS PAPER ADDS</div><div class="abstract-content">Severe motor and non-motor impairments in cerebral palsy (CP) increase epilepsy risk. Epilepsy more likely resolves in bilateral spastic and milder CP impairments. Epilepsy in CP often manifests at an early age with multiple seizure types and high drug resistance. Children with a known genetic cause and CP epilepsy surgery group represent distinct clinical subgroups. </div> <a href="javascript:ShowArticleAbstract(30);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords30" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(30);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh30" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Palsy%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Palsy/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intellectual+Disability%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intellectual Disability</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticonvulsants%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticonvulsants/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Registries%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Registries</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22New+South+Wales%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">New South Wales/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Severity+of+Illness+Index%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Severity of Illness Index</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vision+Disorders%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vision Disorders/etiology</a></li></ul> <a href="javascript:ShowArticleMeSH(30);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant30" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Palsy+Alliance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PG01418 Cerebral Palsy Alliance</a></li></ul> <a href="javascript:ShowArticleGrant(30);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow31"> <td style="min-width: 40px; text-align: center;"> 31 </td> <td> <div id="citation31" class="article-citation"> <b>Zhang K</b>, Yao H, Yang J, Jia T, Shan Q, Li D, Li M, Gan L, Wang X, Dong Y. Analysis of clinical characteristics and histopathological transcription in 40 patients afflicted by epilepsy stemming from focal cortical dysplasia. <em class='incite-journal-name' onclick='ShowInCiteJournal(168119);'>Epilepsia Open</em> 2024;<b>9</b>:981-995. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38491953' target='_blank'>38491953</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11145614' target='_blank'>PMC11145614</a> DOI: <a href='https://dx.doi.org/10.1002/epi4.12928' target='_blank'>10.1002/epi4.12928</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/epi4.12928','38491953', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(31);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(31);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(31);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/epi4.12928' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168119);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/05/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/18/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv31" value="10.1002/epi4.12928" /> <div style="display: none" id="articleAbstract31" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">This study aims to comprehensively analyze the clinical characteristics and identify the differentially expressed genes associated with drug-resistant epilepsy (DRE) in patients with focal cortical dysplasia (FCD). </div><div class="abstract-label">METHODS</div><div class="abstract-content">A retrospective investigation was conducted from July 2019 to June 2022, involving 40 pediatric cases of DRE linked to FCD. Subsequent follow-ups were done to assess post-surgical outcomes. Transcriptomic sequencing and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used to examine differential gene expression between the FCD and control groups. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Among the 40 patients included in the study, focal to bilateral tonic-clonic seizures (13/40, 32.50%) and epileptic spasms (9/40, 22.50%) were the predominant seizure types. Magnetic resonance imaging (MRI) showed frequent involvement of the frontal (22/40, 55%) and temporal lobes (12/40, 30%). In cases with negative MRI results (13/13, 100%), positron emission tomography/computed tomography (PET-CT) scans revealed hypometabolic lesions. Fused MRI/PET-CT images demonstrated lesion reduction in 40.74% (11/27) of cases compared with PET-CT alone, while 59.26% (16/27) yielded results consistent with PET-CT findings. FCD type II was identified in 26 cases, and FCD type I in 13 cases. At the last follow-up, 38 patients were prescribed an average of 1.27 ± 1.05 anti-seizure medications (ASMs), with two patients discontinuing treatment. After a postoperative follow-up period of 23.50 months, 75% (30/40) of patients achieved Engel class I outcome. Transcriptomic sequencing and qRT-PCR analysis identified several genes primarily associated with cilia, including CFAP47, CFAP126, JHY, RSPH4A, and SPAG1. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">This study highlights focal to bilateral tonic-clonic seizures as the most common seizure type in patients with DRE due to FCD. Surgical intervention primarily targeted lesions in the frontal and temporal lobes. Patients with FCD-related DRE showed a promising prognosis for seizure control post-surgery. The identified genes, including CFAP47, CFAP126, JHY, RSPH4A, and SPAG1, could serve as potential biomarkers for FCD. </div><div class="abstract-label">PLAIN LANGUAGE SUMMARY</div><div class="abstract-content">This study aimed to comprehensively evaluate the clinical data of individuals affected by focal cortical dysplasia and analyze transcriptomic data from brain tissues. We found that focal to bilateral tonic-clonic seizures were the most prevalent seizure type in patients with drug-resistant epilepsy. In cases treated surgically, the frontal and temporal lobes were the primary sites of the lesions. Moreover, patients with focal cortical dysplasia-induced drug-resistant epilepsy exhibited a favorable prognosis for seizure control after surgery. CFAP47, CFAP126, JHY, RSPH4A, and SPAG1 have emerged as potential pathogenic genes for the development of focal cortical dysplasia. </div> <a href="javascript:ShowArticleAbstract(31);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords31" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biomarker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22clinical+features%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">clinical features</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug%e2%80%90refractory+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug‐refractory epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22focal+cortical+dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">focal cortical dysplasia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22transcriptome+sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">transcriptome sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(31);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh31" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Positron+Emission+Tomography+Computed+Tomography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Positron Emission Tomography Computed Tomography</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Focal+Cortical+Dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Focal Cortical Dysplasia</a></li></ul> <a href="javascript:ShowArticleMeSH(31);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant31" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(31);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow32"> <td style="min-width: 40px; text-align: center;"> 32 </td> <td> <div id="citation32" class="article-citation"> <b>Babunovska M</b>, Cepreganova Cangovska T, Kuzmanovski I, Noveski P, Plaseska-Karanfilska D, Cvetkovska E. Novel Variant ANKRD11 Gene Mutation Associated With Drug-Resistant Epilepsy in KBG Syndrome Phenotype. <em class='incite-journal-name' onclick='ShowInCiteJournal(18814);'>Pediatr Neurol</em> 2024;<b>155</b>:51-54. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38593730' target='_blank'>38593730</a> DOI: <a href='https://dx.doi.org/10.1016/j.pediatrneurol.2024.03.011' target='_blank'>10.1016/j.pediatrneurol.2024.03.011</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.pediatrneurol.2024.03.011','38593730', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(32);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(32);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.pediatrneurol.2024.03.011' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18814);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/pnu/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/30/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv32" value="10.1016/j.pediatrneurol.2024.03.011" /> <div style="display: none" id="articleAbstract32" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(32);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords32" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ANKRD11+gene+mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ANKRD11 gene mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Combined+generalized+and+focal+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Combined generalized and focal epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug-resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug-resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22KBG+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">KBG syndrome</a></li></ul> <a href="javascript:ShowArticleKeywords(32);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh32" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Repressor+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Repressor Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intellectual+Disability%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intellectual Disability/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Facies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Facies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Abnormalities%2c+Multiple%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Abnormalities, Multiple/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Diseases%2c+Developmental%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Diseases, Developmental/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Megalencephaly%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Megalencephaly/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tooth+Abnormalities%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tooth Abnormalities</a></li></ul> <a href="javascript:ShowArticleMeSH(32);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant32" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(32);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow33"> <td style="min-width: 40px; text-align: center;"> 33 </td> <td> <div id="citation33" class="article-citation"> <b>Buainain RP</b>, Sodré AR, dos Santos JS, Takazaki KAG, Queiroz LDS, de Oliveira CTP, de Aguiar PHP, Marson FAL, Ortega MM. Single-Base Gene Variants in <i>MIR-146A</i> and <i>SCN1A</i> Genes Related to the Epileptogenic Process in Drug-Responsive and Drug-Resistant Temporal Lobe Epilepsy-A Preliminary Study in a Brazilian Cohort Sample. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2024;<b>25</b>:6005. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38892194' target='_blank'>38892194</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172889' target='_blank'>PMC11172889</a> DOI: <a href='https://dx.doi.org/10.3390/ijms25116005' target='_blank'>10.3390/ijms25116005</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms25116005','38892194', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(33);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(33);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(33);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(33);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms25116005' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/21/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv33" value="10.3390/ijms25116005" /> <div style="display: none" id="articleAbstract33" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The drug-resistant temporal lobe epilepsy (TLE) has recently been associated with single nucleotide variants (SNVs) in microRNA(miR)-146a (MIR-146A) (rs2910164) and Sodium Voltage-Gated Channel Alpha Subunit 1 (SCN1A) (rs2298771 and rs3812718) genes. Moreover, no studies have shown an association between these SNVs and susceptibility to drug-resistant and drug-responsive TLE in Brazil. Thus, deoxyribonucleic acid (DNA) samples from 120 patients with TLE (55 drug-responsive and 65 drug-resistant) were evaluated by real-time polymerase chain reaction (RT-PCR). A total of 1171 healthy blood donor individuals from the Online Archive of Brazilian Mutations (ABraOM, from Portuguese Arquivo Brasileiro On-line de Mutações), a repository containing genomic variants of the Brazilian population, were added as a control population for the studied SNVs. MIR-146A and SCN1A relative expression was performed by quantitative RT-PCR (qRT-PCR). The statistical analysis protocol was performed using an alpha error of 0.05. TLE patient samples and ABraOM control samples were in Hardy-Weinberg equilibrium for all studied SNVs. For rs2910164, the frequencies of the homozygous genotype (CC) (15.00% vs. 9.65%) and C allele (37.80% vs. 29.97%) were superior in patients with TLE compared to controls with a higher risk for TLE disease [odds ratio (OR) = 1.89 (95% confidence interval (95%CI) = 1.06-3.37); OR = 1.38 (95%CI = 1.04-1.82), respectively]. Drug-responsive patients also presented higher frequencies of the CC genotype [21.81% vs. 9.65%; OR = 2.58 (95%CI = 1.25-5.30)] and C allele [39.09% vs. 29.97%; OR = 1.50 (95%CI = 1.01-2.22)] compared to controls. For rs2298771, the frequency of the heterozygous genotype (AG) (51.67% vs. 40.40%) was superior in patients with TLE compared to controls with a higher risk for TLE disease [OR = 2.42 (95%CI = 1.08-5.41)]. Drug-resistant patients presented a higher AG frequency [56.92% vs. 40.40%; OR = 3.36 (95%CI = 1.04-17.30)] compared to the control group. For rs3812718, the prevalence of genotypes and alleles were similar in both studied groups. The MIR-146A relative expression level was lower in drug-resistant compared to drug-responsive patients for GC (1.6 vs. 0.1, p-value = 0.049) and CC (1.8 vs. 0.6, p-value = 0.039). Also, the SCN1A relative expression levels in samples from TLE patients were significantly higher in AG [2.09 vs. 1.10, p-value = 0.038] and GG (3.19 vs. 1.10, p-value < 0.001) compared to the AA genotype. In conclusion, the rs2910164-CC and rs2298771-AG genotypes are exerting significant risk influence, respectively, on responsive disease and resistant disease, probably due to an upregulated nuclear factor kappa B (NF-kB) and SCN1A loss of function. </div> <a href="javascript:ShowArticleAbstract(33);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords33" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MIR-146a+gene%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MIR-146a gene</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SCN1A+gene%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SCN1A gene</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug-resistant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug-resistant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug-responsive%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug-responsive</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22single+nucleotide+variant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">single nucleotide variant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22temporal+lobe+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">temporal lobe epilepsy</a></li></ul> <a href="javascript:ShowArticleKeywords(33);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh33" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NAV1.1+Voltage-Gated+Sodium+Channel%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NAV1.1 Voltage-Gated Sodium Channel/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymorphism%2c+Single+Nucleotide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymorphism, Single Nucleotide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brazil%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brazil</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Predisposition+to+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Predisposition to Disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cohort+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cohort Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alleles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alleles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Frequency%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Frequency</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Case-Control+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Case-Control Studies</a></li></ul> <a href="javascript:ShowArticleMeSH(33);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant33" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Council+for+Scientific+and+Technological+Development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">100050/2023-9 National Council for Scientific and Technological Development</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coordination+of+Superior+Level+Staff+Improvement+(CAPES)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">88887464813/2019-00 Coordination of Superior Level Staff Improvement (CAPES)</a></li></ul> <a href="javascript:ShowArticleGrant(33);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow34"> <td style="min-width: 40px; text-align: center;"> 34 </td> <td> <div id="citation34" class="article-citation"> <b>Fu YJ</b>, Piao YS. [Advances of pathological research and classification in malformations of cortical development associated with refractory epilepsy]. <em>ZHONGHUA BING LI XUE ZA ZHI = CHINESE JOURNAL OF PATHOLOGY</em> 2024;<b>53</b>:419-424. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38678320' target='_blank'>38678320</a> DOI: <a href='https://dx.doi.org/10.3760/cma.j.cn112151-20240304-00147' target='_blank'>10.3760/cma.j.cn112151-20240304-00147</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3760/cma.j.cn112151-20240304-00147','38678320', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(34);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(34);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(34);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/29/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv34" value="10.3760/cma.j.cn112151-20240304-00147" /> <div style="display: none" id="articleAbstract34" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">With rapid development of genetic testing techniques, neuroimaging and neuroelectrophysiological technologies, our understanding of malformations of cortical development continues to be deepened and updated. In particular, mutations in genes related to the mammalian target of rapamycin (mTOR) signaling pathway have been successively discovered in focal cortical dysplasia (FCD). At the same time, the classification consensus on FCD issued by the International League Against Epilepsy (ILAE) in 2011 has encountered problems and challenges in diagnostic practice. Therefore, in 2022, ILAE proposed an updated version of the FCD classification based on the progress in molecular genetics over the past decade. The main addition to the classification system is "white matter lesions, " and it is also suggested to integrate histopathological, neuroimaging, and molecular testing results for multi-level integrated diagnosis to achieve reliable, clinically relevant, and therapeutic targeted final diagnosis. </div> <a href="javascript:ShowArticleAbstract(34);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords34" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(34);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh34" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Cortex%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Cortex/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Cortex%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Cortex/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Cortex%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Cortex/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22White+Matter%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">White Matter/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22White+Matter%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">White Matter/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroimaging%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroimaging/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(34);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant34" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Beijing+Natural+Science+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">7242070 Beijing Natural Science Foundation</a></li></ul> <a href="javascript:ShowArticleGrant(34);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow35"> <td style="min-width: 40px; text-align: center;"> 35 </td> <td> <div id="citation35" class="article-citation"> <b>Carton RJ</b>, Doyle MG, Kearney H, Steward CA, Lench NJ, Rogers A, Heinzen EL, McDonald S, Fay J, Lacey A, Beausang A, Cryan J, Brett F, El-Naggar H, Widdess-Walsh P, Costello D, Kilbride R, Doherty CP, Sweeney KJ, O'Brien DF, Henshall DC, Delanty N, Cavalleri GL, Benson KA. Somatic variants as a cause of drug-resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(8564);'>Epilepsia</em> 2024;<b>65</b>:1451-1461. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38491957' target='_blank'>38491957</a> DOI: <a href='https://dx.doi.org/10.1111/epi.17943' target='_blank'>10.1111/epi.17943</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/epi.17943','38491957', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(35);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(35);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(35);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(35);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/epi.17943' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8564);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/29/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/18/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv35" value="10.1111/epi.17943" /> <div style="display: none" id="articleAbstract35" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">The contribution of somatic variants to epilepsy has recently been demonstrated, particularly in the etiology of malformations of cortical development. The aim of this study was to determine the diagnostic yield of somatic variants in genes that have been previously associated with a somatic or germline epilepsy model, ascertained from resected brain tissue from patients with multidrug-resistant focal epilepsy. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Forty-two patients were recruited across three categories: (1) malformations of cortical development, (2) mesial temporal lobe epilepsy with hippocampal sclerosis, and (3) nonlesional focal epilepsy. Participants were subdivided based on histopathology of the resected brain. Paired blood- and brain-derived DNA samples were sequenced using high-coverage targeted next generation sequencing to high depth (585× and 1360×, respectively). Variants were identified using Genome Analysis ToolKit (GATK4) MuTect-2 and confirmed using high-coverage Amplicon-EZ sequencing. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Sequence data on 41 patients passed quality control. Four somatic variants were validated following amplicon sequencing: within CBL, ALG13, MTOR, and FLNA. The diagnostic yield across 41 patients was 10%, 9% in mesial temporal lobe epilepsy with hippocampal sclerosis and 20% in malformations of cortical development. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">This study provides novel insights into the etiology of mesial temporal lobe epilepsy with hippocampal sclerosis, highlighting a potential pathogenic role of somatic variants in CBL and ALG13. We also report candidate diagnostic somatic variants in FLNA in focal cortical dysplasia, while providing further insight into the importance of MTOR and related genes in focal cortical dysplasia. This work demonstrates the potential molecular diagnostic value of variants in both germline and somatic epilepsy genes. </div> <a href="javascript:ShowArticleAbstract(35);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords35" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug%e2%80%90resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug‐resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mesial+temporal+lobe+epilepsy+with+hippocampal+sclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mesial temporal lobe epilepsy with hippocampal sclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22somatic+variants%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">somatic variants</a></li></ul> <a href="javascript:ShowArticleKeywords(35);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh35" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+Foundation+Ireland%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">16/RC/3948 Science Foundation Ireland</a></li></ul> <a href="javascript:ShowArticleGrant(35);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow36"> <td style="min-width: 40px; text-align: center;"> 36 </td> <td> <div id="citation36" class="article-citation"> <b>Alsubhi S</b>, Berrahmoune S, Dudley RWR, Dufresne D, Simard Tremblay E, Srour M, Myers KA. Utility of genetic testing in the pre-surgical evaluation of children with drug-resistant epilepsy. <em class='incite-journal-name' onclick='ShowInCiteJournal(14710);'>J Neurol</em> 2024;<b>271</b>:2503-2508. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38261030' target='_blank'>38261030</a> DOI: <a href='https://dx.doi.org/10.1007/s00415-023-12174-3' target='_blank'>10.1007/s00415-023-12174-3</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00415-023-12174-3','38261030', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(36);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(36);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(36);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(36);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00415-023-12174-3' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14710);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/27/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/24/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv36" value="10.1007/s00415-023-12174-3" /> <div style="display: none" id="articleAbstract36" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">We evaluated the utility of genetic testing in the pre-surgical evaluation of pediatric patients with drug-resistant focal epilepsy. This single-center retrospective study reviewed the charts of all pediatric patients referred for epilepsy surgery evaluation over a 5-year period. We extracted and analyzed results of genetic testing as well as clinical, EEG, and neuroimaging data. Of 125 patients referred for epilepsy surgical evaluation, 86 (69%) had some form of genetic testing. Of these, 18 (21%) had a pathogenic or likely pathogenic variant identified. Genes affected included NPRL3 (3 patients, all related), TSC2 (3 patients), KCNH1, CHRNA4, SPTAN1, DEPDC5, SCN2A, ARX, SCN1A, DLG4, and ST5. One patient had ring chromosome 20, one a 7.17p12 duplication, and one a 15q13 deletion. In six patients, suspected epileptogenic lesions were identified on brain MRI that were thought to be unrelated to the genetic finding. A specific medical therapy choice was allowed due to genetic diagnosis in three patients who did not undergo surgery. Obtaining a molecular diagnosis may dramatically alter management in pediatric patients with drug-resistant focal epilepsy. Genetic testing should be incorporated as part of standard investigations in the pre-surgical work-up of pediatric patients with drug-resistant focal epilepsy. </div> <a href="javascript:ShowArticleAbstract(36);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords36" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CHRNA4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CHRNA4</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug-resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug-resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy+surgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+testing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic testing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NPRL3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NPRL3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SCN2A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SCN2A</a></li></ul> <a href="javascript:ShowArticleKeywords(36);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh36" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Testing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Testing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electroencephalography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electroencephalography</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Preoperative+Care%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Preoperative Care</a></li></ul> <a href="javascript:ShowArticleMeSH(36);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant36" class="article-abstract"> <b style="display: block; 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Association between Genetic Polymorphism of <i>SCN1A</i>, <i>GABRA1</i> and <i>ABCB1</i> and Drug Responsiveness in Vietnamese Epileptic Children. <em>MEDICINA (KAUNAS, LITHUANIA)</em> 2024;<b>60</b>:637. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38674283' target='_blank'>38674283</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11052159' target='_blank'>PMC11052159</a> DOI: <a href='https://dx.doi.org/10.3390/medicina60040637' target='_blank'>10.3390/medicina60040637</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/medicina60040637','38674283', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(37);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(37);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(37);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(37);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/medicina60040637' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv37" value="10.3390/medicina60040637" /> <div style="display: none" id="articleAbstract37" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Background and Objectives: Drug resistant epilepsy (DRE) is a major hurdle in epilepsy, which hinders clinical care, patients' management and treatment outcomes. DRE may partially result from genetic variants that alter proteins responsible for drug targets and drug transporters in the brain. We aimed to examine the relationship between SCN1A, GABRA1 and ABCB1 polymorphism and drug response in epilepsy children in Vietnam. Materials and Methods: In total, 213 children diagnosed with epilepsy were recruited in this study (101 were drug responsive and 112 were drug resistant). Sanger sequencing had been performed in order to detect six single nucleotide polymorphisms (SNPs) belonging to SCN1A (rs2298771, rs3812718, rs10188577), GABRA1 (rs2279020) and ABCB1 (rs1128503, rs1045642) in study group. The link between SNPs and drug response status was examined by the Chi-squared test or the Fisher's exact test. Results: Among six investigated SNPs, two SNPs showed significant difference between the responsive and the resistant group. Among those, heterozygous genotype of SCN1A rs2298771 (AG) were at higher frequency in the resistant patients compared with responsive patients, playing as risk factor of refractory epilepsy. Conversely, the heterozygous genotype of SCN1A rs3812718 (CT) was significantly lower in the resistant compared with the responsive group. No significant association was found between the remaining four SNPs and drug response. Conclusions: Our study demonstrated a significant association between the SCN1A genetic polymorphism which increased risk of drug-resistant epilepsy in Vietnamese epileptic children. This important finding further supports the underlying molecular mechanisms of SCN1A genetic variants in the pathogenesis of drug-resistant epilepsy in children. </div> <a href="javascript:ShowArticleAbstract(37);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords37" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ABCB1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ABCB1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GABRA1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GABRA1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SCN1A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SCN1A</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug-resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug-resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy</a></li></ul> <a href="javascript:ShowArticleKeywords(37);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh37" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NAV1.1+Voltage-Gated+Sodium+Channel%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NAV1.1 Voltage-Gated Sodium Channel/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vietnam%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vietnam</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATP+Binding+Cassette+Transporter%2c+Subfamily+B%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATP Binding Cassette Transporter, Subfamily B/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymorphism%2c+Single+Nucleotide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymorphism, Single Nucleotide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+GABA-A%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, GABA-A/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticonvulsants%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticonvulsants/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Southeast+Asian+People%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Southeast Asian People</a></li></ul> <a href="javascript:ShowArticleMeSH(37);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant37" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22This+study+was+partially+supported+by+the+Department+of+Science+and+Technology+of+Nghe+An+province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NgheAn_Epi This study was partially supported by the Department of Science and Technology of Nghe An province</a></li></ul> <a href="javascript:ShowArticleGrant(37);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow38"> <td style="min-width: 40px; text-align: center;"> 38 </td> <td> <div id="citation38" class="article-citation"> <b>Macdonald-Laurs E</b>, Warren AEL, Francis P, Mandelstam SA, Lee WS, Coleman M, Stephenson SEM, Barton S, D'Arcy C, Lockhart PJ, Leventer RJ, Harvey AS. The clinical, imaging, pathological and genetic landscape of bottom-of-sulcus dysplasia. <em class='incite-journal-name' onclick='ShowInCiteJournal(4140);'>Brain</em> 2024;<b>147</b>:1264-1277. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37939785' target='_blank'>37939785</a> DOI: <a href='https://dx.doi.org/10.1093/brain/awad379' target='_blank'>10.1093/brain/awad379</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1093%2fbrain%2fawad379%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 3</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1093%2fbrain%2fawad379')">Impact Index Per Article: 3.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/brain/awad379','37939785', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(38);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(38);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(38);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(38);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1093/brain/awad379' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4140);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/30/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/20/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/22/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/10/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv38" value="10.1093/brain/awad379" /> <div style="display: none" id="articleAbstract38" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Bottom-of-sulcus dysplasia (BOSD) is increasingly recognized as a cause of drug-resistant, surgically-remediable, focal epilepsy, often in seemingly MRI-negative patients. We describe the clinical manifestations, morphological features, localization patterns and genetics of BOSD, with the aims of improving management and understanding pathogenesis. We studied 85 patients with BOSD diagnosed between 2005-2022. Presenting seizure and EEG characteristics, clinical course, genetic findings and treatment response were obtained from medical records. MRI (3 T) and 18F-FDG-PET scans were reviewed systematically for BOSD morphology and metabolism. Histopathological analysis and tissue genetic testing were performed in 64 operated patients. BOSD locations were transposed to common imaging space to study anatomical location, functional network localization and relationship to normal MTOR gene expression. All patients presented with stereotyped focal seizures with rapidly escalating frequency, prompting hospitalization in 48%. Despite 42% patients having seizure remissions, usually with sodium channel blocking medications, most eventually became drug-resistant and underwent surgery (86% seizure-free). Prior developmental delay was uncommon but intellectual, language and executive dysfunction were present in 24%, 48% and 29% when assessed preoperatively, low intellect being associated with greater epilepsy duration. BOSDs were missed on initial MRI in 68%, being ultimately recognized following repeat MRI, 18F-FDG-PET or image postprocessing. MRI features were grey-white junction blurring (100%), cortical thickening (91%), transmantle band (62%), increased cortical T1 signal (46%) and increased subcortical FLAIR signal (26%). BOSD hypometabolism was present on 18F-FDG-PET in 99%. Additional areas of cortical malformation or grey matter heterotopia were present in eight patients. BOSDs predominated in frontal and pericentral cortex and related functional networks, mostly sparing temporal and occipital cortex, and limbic and visual networks. Genetic testing yielded pathogenic mTOR pathway variants in 63% patients, including somatic MTOR variants in 47% operated patients and germline DEPDC5 or NPRL3 variants in 73% patients with familial focal epilepsy. BOSDs tended to occur in regions where the healthy brain normally shows lower MTOR expression, suggesting these regions may be more vulnerable to upregulation of MTOR activity. Consistent with the existing literature, these results highlight (i) clinical features raising suspicion of BOSD; (ii) the role of somatic and germline mTOR pathway variants in patients with sporadic and familial focal epilepsy associated with BOSD; and (iii) the role of 18F-FDG-PET alongside high-field MRI in detecting subtle BOSD. The anatomical and functional distribution of BOSDs likely explain their seizure, EEG and cognitive manifestations and may relate to relative MTOR expression. </div> <a href="javascript:ShowArticleAbstract(38);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords38" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MRI-negative%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MRI-negative</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy+surgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22focal+cortical+dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">focal cortical dysplasia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mechanistic+target+of+rapamycin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mechanistic target of rapamycin</a></li></ul> <a href="javascript:ShowArticleKeywords(38);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh38" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fluorodeoxyglucose+F18%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fluorodeoxyglucose F18</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epileptic+Syndromes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epileptic Syndromes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GTPase-Activating+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GTPase-Activating Proteins/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(38);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant38" class="article-abstract"> <b style="display: block; 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text-align: center;"> 39 </td> <td> <div id="citation39" class="article-citation"> <b>Xie Y</b>, Su T, Liu Y, Xu S. ATN1-related infantile developmental and epileptic encephalopathy responding to Ketogenic diet. <em class='incite-journal-name' onclick='ShowInCiteJournal(169208);'>Seizure</em> 2024;<b>117</b>:1-5. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38262122' target='_blank'>38262122</a> DOI: <a href='https://dx.doi.org/10.1016/j.seizure.2024.01.012' target='_blank'>10.1016/j.seizure.2024.01.012</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.seizure.2024.01.012','38262122', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(39);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(39);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(39);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.seizure.2024.01.012' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169208);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/23/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/25/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv39" value="10.1016/j.seizure.2024.01.012" /> <div style="display: none" id="articleAbstract39" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Research has shown gene ATN1 to be associated with the nuclear receptor signaling. Its mutations in an evolutionarily conserved histidine-rich motif may cause CHEDDA, short for congenital hypotonia, epilepsy, developmental delay and digital anomalies, a recently identified neurodevelopmental syndrome that could evolve into developmental and epileptic encephalopathy (DEE). Up to date, there have been reported less than 20 cases, whose clinical features and treatment are worth in-depth exploring. </div><div class="abstract-label">METHODS</div><div class="abstract-content">The clinical characteristics and genetic data of an infant with CHEDDA and further DEE were analyzed, who carried a de novo ATN1 variant identified by trio whole-exome sequencing. The alike patients with such a neurodevelopmental syndrome and epileptic seizures were reviewed on the literature. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The infant harboring a de novo missense mutation in ATN1 (c.3155A>C; p.His1052Pro) held almost all features of CHEDDA and presented with drug-resistant epileptic spasms, differing from one case previously reported with the same gene variant exhibiting milder seizures controlled easily. We further reviewed 11 CHEDDA patients with epileptic seizures in the literature and compared the correlation between abnormal cerebral structure and the incidence of intractable epilepsy among CHEDDA patients. Fortunately, this patient's seizures decreased remarkably after administering ketogenic diet (KD). </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">CHEDDA patients have significant phenotypic differences, especially in the epilepsy severity and their drug resistance, even if they carry the same mutation hotspot. Ketogenic diet and other treatments like Topiramate should be recommended for ATN1-related refractory epilepsy based on their regulation on expression of cation-chloride cotransporters and cellular hyperpolarization. </div> <a href="javascript:ShowArticleAbstract(39);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords39" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATN1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATN1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CHEDDA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CHEDDA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Developmental+and+epileptic+encephalopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Developmental and epileptic encephalopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epileptic+spasms%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epileptic spasms</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ketogenic+diet%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ketogenic diet</a></li></ul> <a href="javascript:ShowArticleKeywords(39);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh39" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+Ketogenic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, Ketogenic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spasms%2c+Infantile%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spasms, Infantile/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spasms%2c+Infantile%2fdiet+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spasms, Infantile/diet therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%2c+Missense%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation, Missense</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdiet+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/diet therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nerve+Tissue+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nerve Tissue Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fdiet+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/diet therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(39);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant39" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(39);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow40"> <td style="min-width: 40px; text-align: center;"> 40 </td> <td> <div id="citation40" class="article-citation"> <b>Ferri L</b>, Menghi V, Licchetta L, Dimartino P, Minardi R, Davì C, Di Vito L, Cifaldi E, Zenesini C, Gozzo F, Pelliccia V, Mariani V, de Spelorzi YCC, Gustincich S, Seri M, Tassi L, Pippucci T, Bisulli F. Detection of somatic and germline pathogenic variants in adult cohort of drug-resistant focal epilepsies. <em class='incite-journal-name' onclick='ShowInCiteJournal(8567);'>Epilepsy Behav</em> 2024;<b>153</b>:109716. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38508103' target='_blank'>38508103</a> DOI: <a href='https://dx.doi.org/10.1016/j.yebeh.2024.109716' target='_blank'>10.1016/j.yebeh.2024.109716</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.yebeh.2024.109716','38508103', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(40);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(40);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(40);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.yebeh.2024.109716' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8567);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/eb/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/18/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv40" value="10.1016/j.yebeh.2024.109716" /> <div style="display: none" id="articleAbstract40" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">This study investigates the prevalence of pathogenic variants in the mechanistic target of rapamycin (mTOR) pathway in surgical specimens of malformations of cortical development (MCDs) and cases with negative histology. The study also aims to evaluate the predictive value of genotype-histotype findings on the surgical outcome. </div><div class="abstract-label">METHODS</div><div class="abstract-content">The study included patients with drug-resistant focal epilepsy who underwent epilepsy surgery. Cases were selected based on histopathological diagnosis, focusing on MCDs and negative findings. We included brain tissues both as formalin-fixed, paraffin-embedded (FFPE) or fresh frozen (FF) samples. Single-molecule molecular inversion probes (smMIPs) analysis was conducted, targeting the MTOR gene in FFPE samples and 10 genes within the mTOR pathway in FF samples. Correlations between genotype-histotype and surgical outcome were examined. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">We included 78 patients for whom we obtained 28 FFPE samples and 50 FF tissues. Seventeen pathogenic variants (22 %) were identified and validated, with 13 being somatic within the MTOR gene and 4 germlines (2 DEPDC5, 1 TSC1, 1 TSC2). Pathogenic variants in mTOR pathway genes were exclusively found in FCDII and TSC cases, with a significant association between FCD type IIb and MTOR genotype (P = 0.003). Patients carrying mutations had a slightly better surgical outcome than the overall cohort, however it results not significant. The FCDII diagnosed cases more frequently had normal neuropsychological test, a higher incidence of auras, fewer multiple seizure types, lower occurrence of seizures with awareness impairment, less ictal automatisms, fewer Stereo-EEG investigations, and a longer period long-life of seizure freedom before surgery. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">This study confirms that somatic MTOR variants represent the primary genetic alteration detected in brain specimens from FCDII/TSC cases, while germline DEPDC5, TSC1/TSC2 variants are relatively rare. Systematic screening for these mutations in surgically treated patients' brain specimens can aid histopathological diagnoses and serve as a biomarker for positive surgical outcomes. Certain clinical features associated with pathogenic variants in mTOR pathway genes may suggest a genetic etiology in FCDII patients. </div> <a href="javascript:ShowArticleAbstract(40);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords40" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy+surgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Focal+Cortical+Dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Focal Cortical Dysplasia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histopathological+diagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histopathological diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Somatic+mutations%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Somatic mutations</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Surgical+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Surgical Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mTOR+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mTOR pathway</a></li></ul> <a href="javascript:ShowArticleKeywords(40);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh40" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsies%2c+Partial%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsies, Partial/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Germ+Cells%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Germ Cells/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malformations+of+Cortical+Development%2c+Group+I%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malformations of Cortical Development, Group I</a></li></ul> <a href="javascript:ShowArticleMeSH(40);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant40" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(40);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow41"> <td style="min-width: 40px; text-align: center;"> 41 </td> <td> <div id="citation41" class="article-citation"> <b>Becker L</b>, Makridis KL, Abad‐Perez AT, Thomale U, Tietze A, Elger CE, Horn D, Kaindl AM. The importance of routine genetic testing in pediatric epilepsy surgery. <em class='incite-journal-name' onclick='ShowInCiteJournal(168119);'>Epilepsia Open</em> 2024;<b>9</b>:800-807. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38366963' target='_blank'>38366963</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984286' target='_blank'>PMC10984286</a> DOI: <a href='https://dx.doi.org/10.1002/epi4.12916' target='_blank'>10.1002/epi4.12916</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/epi4.12916','38366963', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(41);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(41);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(41);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(41);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/epi4.12916' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168119);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/19/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv41" value="10.1002/epi4.12916" /> <div style="display: none" id="articleAbstract41" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Genetic variants in relevant genes coexisting with MRI lesions in children with drug-resistant epilepsy (DRE) can negatively influence epilepsy surgery outcomes. Still, presurgical evaluation does not include genetic diagnostics routinely. Here, we report our presurgical evaluation algorithm that includes routine genetic testing. We analyzed retrospectively the data of 68 children with DRE operated at a mean age of 7.8 years (IQR: 8.1 years) at our center. In 49 children, genetic test results were available. We identified 21 gene variants (ACMG III: n = 7, ACMG IV: n = 2, ACMG V: n = 12) in 19 patients (45.2%) in the genes TSC1, TSC2, MECP2, DEPDC5, HUWE1, GRIN1, ASH1I, TRIO, KIF5C, CDON, ANKD11, TGFBR2, ATN1, COL4A1, JAK2, KCNQ2, ATP1A2, and GLI3 by whole-exome sequencing as well as deletions and duplications by array CGH in six patients. While the results did not change the surgery indication, they supported counseling with respect to postoperative chance of seizure freedom and weaning of antiseizure medication (ASM). The presence of genetic findings leads to the postoperative retention of at least one ASM. In our cohort, the International League against Epilepsy (ILAE) seizure outcome did not differ between patients with and without abnormal genetic findings. However, in the 7/68 patients with an unsatisfactory ILAE seizure outcome IV or V 12 months postsurgery, 2 had an abnormal or suspicious genetic finding as a putative explanation for persisting seizures postsurgery, and 3 had received palliative surgery including one TSC patient. This study highlights the importance of genetic testing in children with DRE to address putative underlying germline variants as genetic epilepsy causes or predisposing factors that guide patient and/or parent counseling on a case-by-case with respect to their individual chance of postoperative seizure freedom and ASM weaning. PLAIN LANGUAGE SUMMARY: Genetic variants in children with drug-resistant epilepsy (DRE) can negatively influence epilepsy surgery outcomes. However, presurgical evaluation does not include genetic diagnostics routinely. This retrospective study analyzed the genetic testing results of the 68 pediatric patients who received epilepsy surgery in our center. We identified 21 gene variants by whole-exome sequencing as well as deletions and duplications by array CGH in 6 patients. These results highlight the importance of genetic testing in children with DRE to guide patient and/or parent counseling on a case-by-case with respect to their individual chance of postoperative seizure freedom and ASM weaning. </div> <a href="javascript:ShowArticleAbstract(41);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords41" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy+surgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pediatrics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pediatrics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22variant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">variant</a></li></ul> <a href="javascript:ShowArticleKeywords(41);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh41" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Testing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Testing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Suppressor+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Suppressor Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Suppressor+Proteins%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Suppressor Proteins/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ubiquitin-Protein+Ligases%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ubiquitin-Protein Ligases/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kinesins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kinesins</a></li></ul> <a href="javascript:ShowArticleMeSH(41);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant41" class="article-abstract"> <b style="display: block; 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text-align: center;"> 42 </td> <td> <div id="citation42" class="article-citation"> <b>Kasaiyan M</b>, Basiri M, Pajouhanfar S. The role of miRNA134 in pathogenesis and treatment of intractable epilepsy: a review article. <em>NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS</em> 2024;<b>44</b>:222-237. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38531025' target='_blank'>38531025</a> DOI: <a href='https://dx.doi.org/10.1080/15257770.2024.2331046' target='_blank'>10.1080/15257770.2024.2331046</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15257770.2024.2331046','38531025', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(42);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(42);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(42);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1080/15257770.2024.2331046' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/12/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv42" value="10.1080/15257770.2024.2331046" /> <div style="display: none" id="articleAbstract42" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">MicroRNA-134 (miRNA134) has emerged as a critical regulator in the pathogenesis of epilepsy, particularly in intractable cases resistant to conventional therapies. This review explores the multifaceted roles of miRNA134 in epileptogenesis, focusing on its influence on dendritic spine morphology and synaptic plasticity. Through its interactions with proteins such as LIM kinase 1 (LIMK1), Pumilio 2 (PUM2), and Tubby-like protein 1 (TULP1), miRNA134 modulates various molecular pathways implicated in epilepsy development. Preclinical studies have shown pro-mising results in targeting miRNA134 for mitigating seizure activity, highlighting its potential as a therapeutic target. Furthermore, miRNA134 holds promise as a biomarker for epilepsy diagnosis and prognosis, offering opportunities for personalized treatment approaches. However, further research is warranted to elucidate the precise mechanisms underlying miRNA134's effects and to translate these findings into clinical applications. </div> <a href="javascript:ShowArticleAbstract(42);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords42" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNA134%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNA134</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22brain+restricted+microRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">brain restricted microRNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22intractable+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">intractable epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microRNAs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microRNAs</a></li></ul> <a href="javascript:ShowArticleKeywords(42);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh42" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuronal+Plasticity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuronal Plasticity</a></li></ul> <a href="javascript:ShowArticleMeSH(42);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant42" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(42);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow43"> <td style="min-width: 40px; text-align: center;"> 43 </td> <td> <div id="citation43" class="article-citation"> <b>Zuo RR</b>, Jin M, Sun SZ. Etiological analysis of 167 cases of drug-resistant epilepsy in children. <em class='incite-journal-name' onclick='ShowInCiteJournal(12782);'>Ital J Pediatr</em> 2024;<b>50</b>:50. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38481309' target='_blank'>38481309</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938754' target='_blank'>PMC10938754</a> DOI: <a href='https://dx.doi.org/10.1186/s13052-024-01619-8' target='_blank'>10.1186/s13052-024-01619-8</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s13052-024-01619-8','38481309', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(43);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(43);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(43);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(43);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s13052-024-01619-8' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1186/s13052-024-01619-8');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12782);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/itjp/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/09/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/17/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv43" value="10.1186/s13052-024-01619-8" /> <div style="display: none" id="articleAbstract43" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">To analyze the etiological distribution characteristics of drug-resistant epilepsy (DRE) in children, with the aim of providing valuable perspectives to enhance clinical practice. </div><div class="abstract-label">METHODS</div><div class="abstract-content">In this retrospective study, clinical data were collected on 167 children with DRE who were hospitalized between January 2020 and December 2022, including gender, age of onset, seizure types, video electroencephalogram(VEEG) recordings, neuroimaging, and genetic testing results. Based on the etiology of epilepsy, the enrolled children were categorized into different groups. The rank-sum test was conducted to compare the age of onset for different etiologies. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Of the 167 cases, 89 (53.3%) had a clear etiology. Among them, structural factors account for 23.4%, genetic factors for 19.2%, multiple factors for 7.2%, and immunological factors for 3.6%. The age of onset was significantly earlier in children with genetic causes than those with structural (P < 0.001) or immunological (P = 0.001) causes. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">More than half of children with DRE have a distinct underlying cause, predominantly attributed to structural factors, followed by genetic factors. Genetic etiology primarily manifests at an early age, especially among children aged less than one year. This underscores the need for proactive enhancements in genetic testing to unveil the underlying causes and subsequently guide treatment protocols. </div> <a href="javascript:ShowArticleAbstract(43);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords43" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Children%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Children</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug-resistant+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug-resistant epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Etiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li></ul> <a href="javascript:ShowArticleKeywords(43);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh43" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electroencephalography%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electroencephalography/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(43);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant43" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Key+research+and+development+plan+of+Hebei+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">22377756D Key research and development plan of Hebei Province</a></li></ul> <a href="javascript:ShowArticleGrant(43);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow44"> <td style="min-width: 40px; text-align: center;"> 44 </td> <td> <div id="citation44" class="article-citation"> <b>François L</b>, Romagnolo A, Luinenburg MJ, Anink JJ, Godard P, Rajman M, van Eyll J, Mühlebner A, Skelton A, Mills JD, Dedeurwaerdere S, Aronica E. Identification of gene regulatory networks affected across drug-resistant epilepsies. <em class='incite-journal-name' onclick='ShowInCiteJournal(17180);'>Nat Commun</em> 2024;<b>15</b>:2180. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38467626' target='_blank'>38467626</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928184' target='_blank'>PMC10928184</a> DOI: <a href='https://dx.doi.org/10.1038/s41467-024-46592-2' target='_blank'>10.1038/s41467-024-46592-2</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41467-024-46592-2','38467626', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(44);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(44);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(44);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41467-024-46592-2' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17180);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/01/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/13/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv44" value="10.1038/s41467-024-46592-2" /> <div style="display: none" id="articleAbstract44" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Epilepsy is a chronic and heterogenous disease characterized by recurrent unprovoked seizures, that are commonly resistant to antiseizure medications. This study applies a transcriptome network-based approach across epilepsies aiming to improve understanding of molecular disease pathobiology, recognize affected biological mechanisms and apply causal reasoning to identify therapeutic hypotheses. This study included the most common drug-resistant epilepsies (DREs), such as temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), and mTOR pathway-related malformations of cortical development (mTORopathies). This systematic comparison characterized the global molecular signature of epilepsies, elucidating the key underlying mechanisms of disease pathology including neurotransmission and synaptic plasticity, brain extracellular matrix and energy metabolism. In addition, specific dysregulations in neuroinflammation and oligodendrocyte function were observed in TLE-HS and mTORopathies, respectively. The aforementioned mechanisms are proposed as molecular hallmarks of DRE with the identified upstream regulators offering opportunities for drug-target discovery and development. </div> <a href="javascript:ShowArticleAbstract(44);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords44" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genetics+of+the+nervous+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genetics of the nervous system</a></li></ul> <a href="javascript:ShowArticleKeywords(44);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh44" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Regulatory+Networks%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Regulatory Networks</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(44);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant44" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(44);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow45"> <td style="min-width: 40px; text-align: center;"> 45 </td> <td> <div id="citation45" class="article-citation"> <b>Yang N</b>, Chen L, Zhang Y, Wu X, Hao Y, Yang F, Yang Z, Liang J. Novel NARS2 variants in a patient with early-onset status epilepticus: case study and literature review. <em class='incite-journal-name' onclick='ShowInCiteJournal(4088);'>BMC Pediatr</em> 2024;<b>24</b>:96. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38310242' target='_blank'>38310242</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10837881' target='_blank'>PMC10837881</a> DOI: <a href='https://dx.doi.org/10.1186/s12887-024-04553-0' target='_blank'>10.1186/s12887-024-04553-0</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s12887-024-04553-0','38310242', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(45);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(45);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(45);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(45);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s12887-024-04553-0' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4088);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://submission.nature.com/new-submission/12887/3' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv45" value="10.1186/s12887-024-04553-0" /> <div style="display: none" id="articleAbstract45" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">NARS2 as a member of aminoacyl-tRNA synthetases was necessary to covalently join a specific tRNA to its cognate amino acid. Biallelic variants in NARS2 were reported with disorders such as Leigh syndrome, deafness, epilepsy, and severe myopathy. </div><div class="abstract-label">CASE PRESENTATION</div><div class="abstract-content">Detailed clinical phenotypes were collected and the NARS2 variants were discovered by whole exome sequencing and verified by Sanger sequencing. Additionally, 3D protein structure visualization was performed by UCSF Chimera. The proband in our study had early-onset status epilepticus with abnormal EEG and MRI results. She also performed global developmental delay (GDD) and myocardial dysfunction. Next-generation sequencing (NGS) and Sanger sequencing revealed compound heterozygous missense variants [NM_024678.6:exon14: c.1352G > A(p.Arg451His); c.707T > C(p.Phe236Ser)] of the NARS2 gene. The proband develops refractory epilepsy with GDD and hyperlactatemia. Unfortunately, she finally died for status seizures two months later. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">We discovered two novel missense variants of NARS2 in a patient with early-onset status epilepticus and myocardial dysfunction. The NGS enables the patient to be clearly diagnosed as combined oxidative phosphorylation deficiency 24 (COXPD24, OMIM:616,239), and our findings expands the spectrum of gene variants in COXPD24. </div> <a href="javascript:ShowArticleAbstract(45);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords45" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Global+developmental+delay%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Global developmental delay</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperlactatemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperlactatemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardial+creatine+kinase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardial creatine kinase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NARS2+protein%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NARS2 protein</a></li></ul> <a href="javascript:ShowArticleKeywords(45);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh45" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Status+Epilepticus%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Status Epilepticus/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Status+Epilepticus%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Status Epilepticus/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%2c+Missense%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation, Missense</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Transfer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Transfer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aspartate-tRNA+Ligase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aspartate-tRNA Ligase/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(45);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant45" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+Natural+Science+Foundation+of+Jilin+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">No. YDZJ202201ZYTS090 the Natural Science Foundation of Jilin Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+National+Nature+and+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">No.82271509 & No.81771396 the National Nature and Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+Foundation+of+Jilin+Provincial+Key+Laboratory+of+Pediatric+Neurology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">No. YDZJ202102CXJD021 the Foundation of Jilin Provincial Key Laboratory of Pediatric Neurology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+Project+of+Jilin+Provincial+Science+and+Technology+Development+Plan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">No.YDZJ202201ZYTS676 the Project of Jilin Provincial Science and Technology Development Plan</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+Project+of+Jilin+Medical+and+Health+Talents%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">No.JLSWSRCZX2021053 the Project of Jilin Medical and Health Talents</a></li></ul> <a href="javascript:ShowArticleGrant(45);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow46"> <td style="min-width: 40px; text-align: center;"> 46 </td> <td> <div id="citation46" class="article-citation"> <b>Straka B</b>, Koblížek M, Splítková B, Valkovičová R, Krsková L, Kalinová M, Vlčková M, Zámečník J, Laššuthová P, Sedláčková L, Staněk D, Maulisová A, Tichý M, Kynčl M, Kršek P. A 5-year-old boy with super-refractory status epilepticus and RANBP2 variant warranting life-saving hemispherotomy. <em class='incite-journal-name' onclick='ShowInCiteJournal(168119);'>Epilepsia Open</em> 2024;<b>9</b>:424-431. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37943122' target='_blank'>37943122</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839359' target='_blank'>PMC10839359</a> DOI: <a href='https://dx.doi.org/10.1002/epi4.12863' target='_blank'>10.1002/epi4.12863</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1002%2fepi4.12863%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1002%2fepi4.12863')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/epi4.12863','37943122', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(46);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(46);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(46);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(46);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/epi4.12863' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168119);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/04/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/05/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/10/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv46" value="10.1002/epi4.12863" /> <div style="display: none" id="articleAbstract46" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Focal cortical dysplasia (FCD) represents the most common cause of drug-resistant epilepsy in adult and pediatric surgical series. However, genetic factors contributing to severe phenotypes of FCD remain unknown. We present a patient with an exceptionally rapid development of drug-resistant epilepsy evolving in super-refractory status epilepticus. We performed multiple clinical (serial EEG, MRI), biochemical (metabolic and immunological screening), genetic (WES from blood- and brain-derived DNA), and histopathological investigations. The patient presented 1 month after an uncomplicated varicella infection. MRI was negative, as well as other biochemical and immunological examinations. Whole-exome sequencing of blood-derived DNA detected a heterozygous paternally inherited variant NM_006267.4(RANBP2):c.5233A>G p.(Ile1745Val) (Chr2[GRCh37]:g.109382228A>G), a gene associated with a susceptibility to infection-induced acute necrotizing encephalopathy. No combination of anti-seizure medication led to a sustained seizure freedom and the patient warranted induction of propofol anesthesia with high-dose intravenous midazolam and continuous respiratory support that however failed to abort seizure activity. Brain biopsy revealed FCD type IIa; this finding led to the indication of an emergency right-sided hemispherotomy that rendered the patient temporarily seizure-free. Postsurgically, he remains on antiseizure medication and experiences rare nondisabling seizures. This report highlights a uniquely severe clinical course of FCD putatively modified by the RANBP2 variant. PLAIN LANGUAGE SUMMARY: We report a case summary of a patient who came to our attention for epilepsy that could not be controlled with medication. His clinical course progressed rapidly to life-threatening status epilepticus with other unusual neurological findings. Therefore, we decided to surgically remove a piece of brain tissue in order to clarify the diagnosis that showed features of a structural brain abnormality associated with severe epilepsy, the focal cortical dysplasia. Later, a genetic variant in a gene associated with another condition, was found, and we hypothesize that this genetic variant could have contributed to this severe clinical course of our patient. </div> <a href="javascript:ShowArticleAbstract(46);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords46" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%5cnRANBP2%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"> RANBP2 </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy+surgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22focal+cortical+dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">focal cortical dysplasia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hemispherotomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hemispherotomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22refractory+status+epilepticus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">refractory status epilepticus</a></li></ul> <a href="javascript:ShowArticleKeywords(46);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh46" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Progression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Focal+Cortical+Dysplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Focal Cortical Dysplasia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Midazolam%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Midazolam</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Chaperones%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Chaperones</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nuclear+Pore+Complex+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nuclear Pore Complex Proteins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Status+Epilepticus%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Status Epilepticus/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Status+Epilepticus%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Status Epilepticus/surgery</a></li></ul> <a href="javascript:ShowArticleMeSH(46);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant46" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Grantov%c3%a1+Agentura%2c+Univerzita+Karlova%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">94121 Grantová Agentura, Univerzita Karlova</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministerstvo+%c5%a0kolstv%c3%ad%2c+Ml%c3%a1de%c5%bee+a+T%c4%9blov%c3%bdchovy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LX22NPO5107 Ministerstvo Školství, Mládeže a Tělovýchovy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministerstvo+Zdravotnictv%c3%ad+Cesk%c3%a9+Republiky%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">00064203 Ministerstvo Zdravotnictví Ceské Republiky</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministerstvo+Zdravotnictv%c3%ad+Cesk%c3%a9+Republiky%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NV19-04-00369 Ministerstvo Zdravotnictví Ceské Republiky</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Grantov%c3%a1+Agentura%2c+Univerzita+Karlova%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Grantová Agentura, Univerzita Karlova </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministerstvo+%c5%a0kolstv%c3%ad%2c+Ml%c3%a1de%c5%bee+a+T%c4%9blov%c3%bdchovy%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ministerstvo Školství, Mládeže a Tělovýchovy </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministerstvo+Zdravotnictv%c3%ad+Cesk%c3%a9+Republiky%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ministerstvo Zdravotnictví Ceské Republiky </a></li></ul> <a href="javascript:ShowArticleGrant(46);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow47"> <td style="min-width: 40px; text-align: center;"> 47 </td> <td> <div id="citation47" class="article-citation"> <b>Khalilov VS</b>, Kislyakov AN, Kuznetsova AA, Ryleva OA, Kholin AA, Zavadenko NN. [Ganglioglioma with an atypical histopathological phenotype or a new entity of the LEAT group?]. <em class='incite-journal-name' onclick='ShowInCiteJournal(169151);'>Zh Nevrol Psikhiatr Im S S Korsakova</em> 2024;<b>124</b>:67-73. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39575962' target='_blank'>39575962</a> DOI: <a href='https://dx.doi.org/10.17116/jnevro202412410167' target='_blank'>10.17116/jnevro202412410167</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.17116/jnevro202412410167','39575962', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(47);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(47);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(47);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.17116/jnevro202412410167' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169151);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/20/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv47" value="10.17116/jnevro202412410167" /> <div style="display: none" id="articleAbstract47" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The article reports the discovery of pathological substrates with an atypical histopathological phenotype in the brains of patients undergoing surgery for drug-resistant structural epilepsy. A complete panel of histopathological staining and immunohistochemical analysis with a wide range of antibodies were available at pathological examination. In addition to pathomorphological verification, molecular genetic testing was performed for the presence of mutations in the BRAF genes at codon 600 and BRAF/KIAA1549. MRI was performed at 3.0 Tl tomography using a standard protocol and an epileptic scanning protocol. During pathomorphological examination, the patients showed mixed signs of ganglioglioma CNS WHO grade 1 and focal cortical dysplasia type IIb. This mixed combination of pathological processes in one substrate has not yet been described in publicly available sources and does not fit the definition of double pathology, when they can coexist next door, but have clear differentiation. On MRI, the pathological substrates were localized in the frontal and temporal lobes, did not demonstrate typical radiological criteria of a tumor, had a "transmantle" distribution from the the lateral ventricles to the cortex with local and regional smoothing of the gray-white demarcation and uneven thickening of the cortical plate in the area of interest. In one case, large calcification associated with cavitation of the white matter was found in the structure of the pathological substrate. In another case, the substrate showed decreased blood flow in the substrate structure on perfusion maps. The described epileptogenic substrates differ markedly from classical gangliogliomas with two cell pools according to pathomorphological, molecular genetic and radiological criteria. The published results may indicate a completely new subgroup of gangliogliomas with cellular atypia, or a previously unknown combination of two pathological processes, or argue in favor of a common origin of neuronal-glial tumors and FCD. These data require prospective verification on a larger cohort of patients and an in-depth study of the molecular genetic profile of the described pathological substrates in order to reliably verify their origin. </div> <a href="javascript:ShowArticleAbstract(47);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords47" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22focal+cortical+dysplasia+type+IIb%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">focal cortical dysplasia type IIb</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ganglioglioma+with+atypical+histopathological+phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ganglioglioma with atypical histopathological phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22structural+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">structural epilepsy</a></li></ul> <a href="javascript:ShowArticleKeywords(47);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh47" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+B-raf%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins B-raf/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(47);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant47" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(47);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow48"> <td style="min-width: 40px; text-align: center;"> 48 </td> <td> <div id="citation48" class="article-citation"> <b>Bertoli G</b>, Fortunato F, Cava C, Manna I, Gallivanone F, Labate A, Panio A, Porro D, Gambardella A. Serum MicroRNAs as Predictors of Diagnosis and Drug-resistance in Temporal Lobe Epilepsy: A Preliminary Study. <em class='incite-journal-name' onclick='ShowInCiteJournal(7502);'>Curr Neuropharmacol</em> 2024;<b>22</b>:2422-2432. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39403059' target='_blank'>39403059</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11451323' target='_blank'>PMC11451323</a> DOI: <a href='https://dx.doi.org/10.2174/1570159x22666240516145823' target='_blank'>10.2174/1570159x22666240516145823</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.2174/1570159x22666240516145823','39403059', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(48);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(48);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(48);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.2174/1570159x22666240516145823' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7502);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/14/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/18/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/19/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv48" value="10.2174/1570159x22666240516145823" /> <div style="display: none" id="articleAbstract48" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Temporal lobe epilepsy (TLE) is the most common form of refractory focal epilepsy, and the current clinical diagnosis is based on EEG, clinical neurological history and neuroimaging findings. </div><div class="abstract-label">METHODS</div><div class="abstract-content">So far, there are no blood-based molecular biomarkers of TLE to support clinical diagnosis, despite the pathogenic mechanisms underlying TLE involving defects in the regulation of gene expression. MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene expression. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Recent studies show the feasibility of detecting miRNAs in body fluids; circulating miRNAs have emerged as potential clinical biomarkers in epilepsy, although the TLE miRNA profile needs to be addressed. Here, we analysed the diagnostic potential of 8 circulating miRNAs in sera of 52 TLE patients and 40 age- and sex-matched donor controls by RT-qPCR analyses. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">We found that miR-34a-5p, -106b-5p, -130a-3p, -146a-5p, and -19a-3p are differently expressed in TLE compared to control subjects, suggesting a diagnostic role. Furthermore, we found that miR-34a-5p, -106b-5p, -146a-5p and miR-451a could become prognostic biomarkers, being differentially expressed between drug-resistant and drug-responsive TLE subjects. Therefore, serum miRNAs are diagnostic and drug-resistance predictive molecules of TLE. </div> <a href="javascript:ShowArticleAbstract(48);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords48" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TLE%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TLE</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Temporal+lobe+epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Temporal lobe epilepsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22circulating+biomarkers.%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">circulating biomarkers.</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22diagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miRNAs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miRNAs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microRNAs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microRNAs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prediction+of+therapy+response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prediction of therapy response</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prognosis</a></li></ul> <a href="javascript:ShowArticleKeywords(48);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh48" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2c+Temporal+Lobe%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy, Temporal Lobe/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticonvulsants%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticonvulsants/therapeutic use</a></li></ul> <a href="javascript:ShowArticleMeSH(48);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant48" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(48);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow49"> <td style="min-width: 40px; text-align: center;"> 49 </td> <td> <div id="citation49" class="article-citation"> <b>Horvat D</b>, Kaminski M, Ma Y. A case of drug-resistant epilepsy and autism with de novo SLC6A8 gene variant. <em class='incite-journal-name' onclick='ShowInCiteJournal(169208);'>Seizure</em> 2023;<b>113</b>:16-18. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37924775' target='_blank'>37924775</a> DOI: <a href='https://dx.doi.org/10.1016/j.seizure.2023.10.009' target='_blank'>10.1016/j.seizure.2023.10.009</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.seizure.2023.10.009','37924775', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(49);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.seizure.2023.10.009' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169208);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/22/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/19/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/22/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/06/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv49" value="10.1016/j.seizure.2023.10.009" /> <div style="display: none" id="articleAbstract49" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(49);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords49" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(49);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh49" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autism+Spectrum+Disorder%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autism Spectrum Disorder/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autism+Spectrum+Disorder%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autism Spectrum Disorder/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nerve+Tissue+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nerve Tissue Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plasma+Membrane+Neurotransmitter+Transport+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plasma Membrane Neurotransmitter Transport Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li></ul> <a href="javascript:ShowArticleMeSH(49);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant49" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(49);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow50"> <td style="min-width: 40px; text-align: center;"> 50 </td> <td> <div id="citation50" class="article-citation"> <b>Hansen SN</b>, Holm A, Kauppinen S, Klitgaard H. RNA therapeutics for epilepsy: An emerging modality for drug discovery. <em class='incite-journal-name' onclick='ShowInCiteJournal(8564);'>Epilepsia</em> 2023;<b>64</b>:3113-3129. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37703096' target='_blank'>37703096</a> DOI: <a href='https://dx.doi.org/10.1111/epi.17772' target='_blank'>10.1111/epi.17772</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1111%2fepi.17772%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 3</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1111%2fepi.17772')">Impact Index Per Article: 1.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/epi.17772','37703096', 'Drug Resistant Epilepsy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(50);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(50);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(50);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(50);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/epi.17772' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8564);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/14/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/04/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/11/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/14/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv50" value="10.1111/epi.17772" /> <div style="display: none" id="articleAbstract50" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Drug discovery in epilepsy began with the finding of potassium bromide by Sir Charles Locock in 1857. The following century witnessed the introduction of phenotypic screening tests for discovering antiseizure medications (ASMs). Despite the high success rate of developing ASMs, they have so far failed in eliminating drug resistance and in delivering disease-modifying treatments. This emphasizes the need for new drug discovery strategies in epilepsy. RNA-based drugs have recently shown promise as a new modality with the potential of providing disease modification and counteracting drug resistance in epilepsy. RNA therapeutics can be directed either toward noncoding RNAs, such as microRNAs, long noncoding RNAs (ncRNAs), and circular RNAs, or toward messenger RNAs. The former show promise in sporadic, nongenetic epilepsies, as interference with ncRNAs allows for modulation of entire disease pathways, whereas the latter seem more promising in monogenic childhood epilepsies. Here, we describe therapeutic strategies for modulating disease-associated RNA molecules and highlight the potential of RNA therapeutics for the treatment of different patient populations such as sporadic, drug-resistant epilepsy, and childhood monogenic epilepsies. </div> <a href="javascript:ShowArticleAbstract(50);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords50" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ASO%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ASO</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA+medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA medicine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22seizures%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">seizures</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22siRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">siRNA</a></li></ul> <a href="javascript:ShowArticleKeywords(50);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh50" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistant Epilepsy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Discovery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Discovery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistance</a></li></ul> <a href="javascript:ShowArticleMeSH(50);" 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page-number" href="/Search?page=4&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">4</a><a class="dxp-num page-number" href="/Search?page=5&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">5</a><a class="dxp-button dxp-bi" onclick="ASPx.PGNav(event);" href="/Search?page=3&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistant+Epilepsy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;"><img class="dxWeb_pNext_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Next" /></a> </div><b class="dx-clear"></b><script id="dxss_1510059330" type="text/javascript">  </script> </div> </div> <div class="cl"></div> </div> </div> </div> <table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="RootHolder_LeftLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="text-align:Center;vertical-align:Top;"><span id="RootHolder_LeftLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="RootHolder_LeftLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1950550554" type="text/javascript">  </script> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleCitationPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleCitationPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1115091042" type="text/javascript">  </script> <div id="RootHolder_chartPopupControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Drug Resistant Epilepsy/genetics (104 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="104" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Drug Resistant Epilepsy/genetics (104 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="104" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:455px;width:420px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:14pt;font-style:italic;border-bottom-style:Solid;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Welcome to Reference Citation Analysis</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1691100642" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>