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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="QcraYV03d_Jtqvtv-5HTfx2XdIsMDuwhtUMk4hNvyZhFoPRrdT9Q_7dYMnvTtkZjqqzjo41lqkd9qbzZwcAPPg" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/114143508/Anti_inflammatory_and_wound_healing_properties_of_Rubus_fairholmianus_Gard_root_An_in_vivo_study" /> <meta name="twitter:title" content="Anti-inflammatory and wound healing properties of Rubus fairholmianus Gard. root—An in vivo study" /> <meta name="twitter:description" content="ABSTRACT This study aims to develop an effective therapeutic agent from Rubus fairholmianus root acetone extract (RFRA) against inflammatory related diseases as this plant is being used in folk medicine to treat various other ailments. 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The root" /> <meta property="article:author" content="https://independent.academia.edu/BlassanGeorge" /> <meta name="description" content="ABSTRACT This study aims to develop an effective therapeutic agent from Rubus fairholmianus root acetone extract (RFRA) against inflammatory related diseases as this plant is being used in folk medicine to treat various other ailments. The root" /> <meta name="robots" content="noindex" /> <title>Anti-inflammatory and wound healing properties of Rubus fairholmianus Gard. root—An in vivo study</title> <link rel="canonical" href="https://www.academia.edu/114143508/Anti_inflammatory_and_wound_healing_properties_of_Rubus_fairholmianus_Gard_root_An_in_vivo_study" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = 'dc2ad41da5d7ea682babd20f90650302fb0a3a36'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1739790456000); window.Aedu.timeDifference = new Date().getTime() - 1739790456000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"ABSTRACT This study aims to develop an effective therapeutic agent from Rubus fairholmianus root acetone extract (RFRA) against inflammatory related diseases as this plant is being used in folk medicine to treat various other ailments. The root acetone extract (up to 2000 mg/kg b. wt.) was used to observe acute toxicity in mice for 14 days. Two doses (200 and 400 mg/kg) were used to evaluate anti-inflammatory activity using carrageenan induced paw edema in rats and croton oil induced ear edema in mice. Both the doses significantly reduced the paw and ear edema compared to indomethacin. The acute dermal toxicity studies for RFRA extract were carried out and examined for wound healing activity at two doses (1% and 2%) in excision, incision, staphylococcus aureus infected and burn wound models in rat. RFRA 2% depicted significant wound healing properties; by increasing the percentage of wound contraction thereby by decreasing the period of epithelization compared with betadine (5%) and neomycin (5%). We have assumed that the peak shown close to the standard quercetin in the extract could be quercetin like compound (20.89 min). RFRA showed significant anti-inflammatory and wound healing properties which may be due to the presence of analogues of quercetin and other related polyphenolic compounds and hence it has immense scope as an effective source to develop a drug for the treatment of inflammatory related disorders.","author":[{"@context":"https://schema.org","@type":"Person","name":"Blassan George","url":"https://independent.academia.edu/BlassanGeorge"}],"contributor":[],"dateCreated":"2024-01-28","dateModified":"2024-01-28","datePublished":"2014-03-01","headline":"Anti-inflammatory and wound healing properties of Rubus fairholmianus Gard. root—An in vivo study","image":"https://a.academia-assets.com/images/blank-paper.jpg","inLanguage":"en","keywords":["Wound Healing","In Vivo","Rubus"],"publication":"Industrial Crops and Products","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Elsevier BV"},"sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}],"thumbnailUrl":"https://a.academia-assets.com/images/blank-paper.jpg","url":"https://www.academia.edu/114143508/Anti_inflammatory_and_wound_healing_properties_of_Rubus_fairholmianus_Gard_root_An_in_vivo_study"}</script><style type="text/css">@media(max-width: 567px){:root{--token-mode: Rebrand;--dropshadow: 0 2px 4px 0 #22223340;--primary-brand: #0645b1;--error-dark: #b60000;--success-dark: #05b01c;--inactive-fill: #ebebee;--hover: #0c3b8d;--pressed: #082f75;--button-primary-fill-inactive: #ebebee;--button-primary-fill: #0645b1;--button-primary-text: #ffffff;--button-primary-fill-hover: #0c3b8d;--button-primary-fill-press: #082f75;--button-primary-icon: #ffffff;--button-primary-fill-inverse: #ffffff;--button-primary-text-inverse: #082f75;--button-primary-icon-inverse: #0645b1;--button-primary-fill-inverse-hover: #cddaef;--button-primary-stroke-inverse-pressed: 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{"work":{"id":114143508,"created_at":"2024-01-28T03:03:18.490-08:00","from_world_paper_id":248944813,"updated_at":"2024-01-28T03:26:23.494-08:00","_data":{"abstract":"ABSTRACT This study aims to develop an effective therapeutic agent from Rubus fairholmianus root acetone extract (RFRA) against inflammatory related diseases as this plant is being used in folk medicine to treat various other ailments. The root acetone extract (up to 2000 mg/kg b. wt.) was used to observe acute toxicity in mice for 14 days. Two doses (200 and 400 mg/kg) were used to evaluate anti-inflammatory activity using carrageenan induced paw edema in rats and croton oil induced ear edema in mice. Both the doses significantly reduced the paw and ear edema compared to indomethacin. The acute dermal toxicity studies for RFRA extract were carried out and examined for wound healing activity at two doses (1% and 2%) in excision, incision, staphylococcus aureus infected and burn wound models in rat. RFRA 2% depicted significant wound healing properties; by increasing the percentage of wound contraction thereby by decreasing the period of epithelization compared with betadine (5%) and neomycin (5%). We have assumed that the peak shown close to the standard quercetin in the extract could be quercetin like compound (20.89 min). RFRA showed significant anti-inflammatory and wound healing properties which may be due to the presence of analogues of quercetin and other related polyphenolic compounds and hence it has immense scope as an effective source to develop a drug for the treatment of inflammatory related disorders.","publisher":"Elsevier BV","publication_date":"2014,3,1","publication_name":"Industrial Crops and Products"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":null,"language":"en","title":"Anti-inflammatory and wound healing properties of Rubus fairholmianus Gard. root—An in vivo study","broadcastable":false,"draft":null,"has_indexable_attachment":null,"indexable":true}}["work"]; window.loswp.workCoauthors = [10849334]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "grid"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="loswp-grid--container"><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-landing_url="https://www.academia.edu/114143508/Anti_inflammatory_and_wound_healing_properties_of_Rubus_fairholmianus_Gard_root_An_in_vivo_study" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="above-fold js-swp-splash-above-fold"><div class="work-card--container js-swp-control-work-card" data-entity-id="114143508"><div class="work-cover--wrapper"><div class="work-cover--container"><div class="work-cover--no-attachment-container js-swp-splash-paper-cover"><div class="work-cover--file-icon-wrapper"><img alt="paper cover icon" src="//a.academia-assets.com/images/single_work_splash/adobe.icon.svg" /></div><div class="work-cover--title js-swp-splash-paper-cover-page-title">Anti-inflammatory and wound healing properties of Rubus fairholmianus Gard. root—An in vivo study</div><br /><div style="margin-top: 170px"><button class="work-cover--request-pdf-button js-request-pdf-button"><svg style="width: 14px; margin-right: 8px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="envelope" class="svg-inline--fa fa-envelope fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M502.3 190.8c3.9-3.1 9.7-.2 9.7 4.7V400c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V195.6c0-5 5.7-7.8 9.7-4.7 22.4 17.4 52.1 39.5 154.1 113.6 21.1 15.4 56.7 47.8 92.2 47.6 35.7.3 72-32.8 92.3-47.6 102-74.1 131.6-96.3 154-113.7zM256 320c23.2.4 56.6-29.2 73.4-41.4 132.7-96.3 142.8-104.7 173.4-128.7 5.8-4.5 9.2-11.5 9.2-18.9v-19c0-26.5-21.5-48-48-48H48C21.5 64 0 85.5 0 112v19c0 7.4 3.4 14.3 9.2 18.9 30.6 23.9 40.7 32.4 173.4 128.7 16.8 12.2 50.2 41.8 73.4 41.4z"></path></svg>Request PDF</button></div></div></div></div><div class="work-card--content"><h1 class="work-card--title">Anti-inflammatory and wound healing properties of Rubus fairholmianus Gard. root—An in vivo study</h1><div class="work-card--pub-info">Industrial Crops and Products, 2014</div><a class="js-profile-link work-card--single-author" data-has-card-for-user="10849334" href="https://independent.academia.edu/BlassanGeorge?swp=tc-au-114143508"><div class="work-card--single-author-photo"><img class="Avatar--circle s65 Avatar--circle s65 Avatar--xxxs" alt="Blassan George" shape="circle" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s65_no_pic.png') this.src = '//a.academia-assets.com/images/s65_no_pic.png';" width="65" height="65" src="https://0.academia-photos.com/10849334/14985311/15729857/s65_blassan.george.jpg" /></div><div class="work-card--author-name-wrapper" style="max-width: 125px; font-weight: 500; color: #4b4b4b;"><div class="u-textTruncate"><span itemprop="author">Blassan George</span></div></div></a><script data-card-contents-for-user="10849334" type="text/json">{"id":10849334,"first_name":"Blassan","middle_initials":null,"last_name":"George","page_name":"BlassanGeorge","domain_name":"independent","created_at":"2014-04-06T00:31:18.566-07:00","display_name":"Blassan George","url":"https://independent.academia.edu/BlassanGeorge","photo":"https://0.academia-photos.com/10849334/14985311/15729857/s65_blassan.george.jpg","has_photo":true,"interests":[{"id":698878,"name":"莊子 Zhuangzi，畢來德Jean François Billeter，跨文化研究，跨文化批判，台灣民主政治","url":"https://www.academia.edu/Documents/in/_Zhuangzi_Jean_Francois_Billeter_"}]}</script><div class="work-card--no-attachment-details"><div style="font-weight: 700; font-size: 14px;">Abstract</div><div class="work-card--abstract js-swp-splash-abstract">ABSTRACT This study aims to develop an effective therapeutic agent from Rubus fairholmianus root acetone extract (RFRA) against inflammatory related diseases as this plant is being used in folk medicine to treat various other ailments. The root acetone extract (up to 2000 mg/kg b. wt.) was used to observe acute toxicity in mice for 14 days. Two doses (200 and 400 mg/kg) were used to evaluate anti-inflammatory activity using carrageenan induced paw edema in rats and croton oil induced ear edema in mice. Both the doses significantly reduced the paw and ear edema compared to indomethacin. The acute dermal toxicity studies for RFRA extract were carried out and examined for wound healing activity at two doses (1% and 2%) in excision, incision, staphylococcus aureus infected and burn wound models in rat. RFRA 2% depicted significant wound healing properties; by increasing the percentage of wound contraction thereby by decreasing the period of epithelization compared with betadine (5%) and neomycin (5%). We have assumed that the peak shown close to the standard quercetin in the extract could be quercetin like compound (20.89 min). RFRA showed significant anti-inflammatory and wound healing properties which may be due to the presence of analogues of quercetin and other related polyphenolic compounds and hence it has immense scope as an effective source to develop a drug for the treatment of inflammatory related disorders.</div></div><div class="request-upload--container"><p class="request-upload--title">Blassan George hasn't uploaded this paper.</p><div class="request-upload--info-text"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="info-circle" class="request-upload--info-icon svg-inline--fa fa-info-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z"></path></svg><p class="no-margin hide-on-small-mobile">Let Blassan know you want this paper to be uploaded.</p><p class="no-margin hide-above-small-mobile">Ask for this paper to be uploaded.</p></div><button class="work-cover--request-pdf-button small js-request-pdf-button hide-on-desktop"><svg style="width: 14px; 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