CINXE.COM

<!DOCTYPE html> <html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available" lang="en" dir="ltr"> <head> <meta charset="UTF-8"> <title>Death receptor 3 - Wikipedia</title> <script>(function(){var className="client-js vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available";var cookie=document.cookie.match(/(?:^|; )enwikimwclientpreferences=([^;]+)/);if(cookie){cookie[1].split('%2C').forEach(function(pref){className=className.replace(new RegExp('(^| )'+pref.replace(/-clientpref-\w+$|[^\w-]+/g,'')+'-clientpref-\\w+( |$)'),'$1'+pref+'$2');});}document.documentElement.className=className;}());RLCONF={"wgBreakFrames":false,"wgSeparatorTransformTable":["",""],"wgDigitTransformTable":["",""],"wgDefaultDateFormat":"dmy", "wgMonthNames":["","January","February","March","April","May","June","July","August","September","October","November","December"],"wgRequestId":"8485c9b1-fe77-4f50-823c-2442e736a959","wgCanonicalNamespace":"","wgCanonicalSpecialPageName":false,"wgNamespaceNumber":0,"wgPageName":"Death_receptor_3","wgTitle":"Death receptor 3","wgCurRevisionId":1215963743,"wgRevisionId":1215963743,"wgArticleId":14772549,"wgIsArticle":true,"wgIsRedirect":false,"wgAction":"view","wgUserName":null,"wgUserGroups":["*"],"wgCategories":["Articles with short description","Short description is different from Wikidata","Wikipedia articles incorporating text from the United States National Library of Medicine","Genes on human chromosome 1","TNF receptor family"],"wgPageViewLanguage":"en","wgPageContentLanguage":"en","wgPageContentModel":"wikitext","wgRelevantPageName":"Death_receptor_3","wgRelevantArticleId":14772549,"wgIsProbablyEditable":true,"wgRelevantPageIsProbablyEditable":true,"wgRestrictionEdit":[], "wgRestrictionMove":[],"wgNoticeProject":"wikipedia","wgCiteReferencePreviewsActive":false,"wgFlaggedRevsParams":{"tags":{"status":{"levels":1}}},"wgMediaViewerOnClick":true,"wgMediaViewerEnabledByDefault":true,"wgPopupsFlags":0,"wgVisualEditor":{"pageLanguageCode":"en","pageLanguageDir":"ltr","pageVariantFallbacks":"en"},"wgMFDisplayWikibaseDescriptions":{"search":true,"watchlist":true,"tagline":false,"nearby":true},"wgWMESchemaEditAttemptStepOversample":false,"wgWMEPageLength":10000,"wgRelatedArticlesCompat":[],"wgCentralAuthMobileDomain":false,"wgEditSubmitButtonLabelPublish":true,"wgULSPosition":"interlanguage","wgULSisCompactLinksEnabled":false,"wgVector2022LanguageInHeader":true,"wgULSisLanguageSelectorEmpty":false,"wgWikibaseItemId":"Q18033239","wgCheckUserClientHintsHeadersJsApi":["brands","architecture","bitness","fullVersionList","mobile","model","platform","platformVersion"],"GEHomepageSuggestedEditsEnableTopics":true,"wgGETopicsMatchModeEnabled":false, "wgGEStructuredTaskRejectionReasonTextInputEnabled":false,"wgGELevelingUpEnabledForUser":false};RLSTATE={"ext.globalCssJs.user.styles":"ready","site.styles":"ready","user.styles":"ready","ext.globalCssJs.user":"ready","user":"ready","user.options":"loading","ext.cite.styles":"ready","skins.vector.search.codex.styles":"ready","skins.vector.styles":"ready","skins.vector.icons":"ready","jquery.makeCollapsible.styles":"ready","ext.wikimediamessages.styles":"ready","ext.visualEditor.desktopArticleTarget.noscript":"ready","ext.uls.interlanguage":"ready","wikibase.client.init":"ready","ext.wikimediaBadges":"ready"};RLPAGEMODULES=["ext.cite.ux-enhancements","site","mediawiki.page.ready","jquery.makeCollapsible","mediawiki.toc","skins.vector.js","ext.centralNotice.geoIP","ext.centralNotice.startUp","ext.gadget.ReferenceTooltips","ext.gadget.switcher","ext.urlShortener.toolbar","ext.centralauth.centralautologin","mmv.bootstrap","ext.popups","ext.visualEditor.desktopArticleTarget.init", "ext.visualEditor.targetLoader","ext.echo.centralauth","ext.eventLogging","ext.wikimediaEvents","ext.navigationTiming","ext.uls.interface","ext.cx.eventlogging.campaigns","ext.cx.uls.quick.actions","wikibase.client.vector-2022","ext.checkUser.clientHints","ext.growthExperiments.SuggestedEditSession","wikibase.sidebar.tracking"];</script> <script>(RLQ=window.RLQ||[]).push(function(){mw.loader.impl(function(){return["user.options@12s5i",function($,jQuery,require,module){mw.user.tokens.set({"patrolToken":"+\\","watchToken":"+\\","csrfToken":"+\\"}); }];});});</script> <link rel="stylesheet" href="/w/load.php?lang=en&modules=ext.cite.styles%7Cext.uls.interlanguage%7Cext.visualEditor.desktopArticleTarget.noscript%7Cext.wikimediaBadges%7Cext.wikimediamessages.styles%7Cjquery.makeCollapsible.styles%7Cskins.vector.icons%2Cstyles%7Cskins.vector.search.codex.styles%7Cwikibase.client.init&only=styles&skin=vector-2022"> <script async="" src="/w/load.php?lang=en&modules=startup&only=scripts&raw=1&skin=vector-2022"></script> <meta name="ResourceLoaderDynamicStyles" content=""> <link rel="stylesheet" href="/w/load.php?lang=en&modules=site.styles&only=styles&skin=vector-2022"> <meta name="generator" content="MediaWiki 1.44.0-wmf.4"> <meta name="referrer" content="origin"> <meta name="referrer" content="origin-when-cross-origin"> <meta name="robots" content="max-image-preview:standard"> <meta name="format-detection" content="telephone=no"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/1200px-Ideogram_human_chromosome_1.svg.png"> <meta property="og:image:width" content="1200"> <meta property="og:image:height" content="478"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/800px-Ideogram_human_chromosome_1.svg.png"> <meta property="og:image:width" content="800"> <meta property="og:image:height" content="319"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/640px-Ideogram_human_chromosome_1.svg.png"> <meta property="og:image:width" content="640"> <meta property="og:image:height" content="255"> <meta name="viewport" content="width=1120"> <meta property="og:title" content="Death receptor 3 - Wikipedia"> <meta property="og:type" content="website"> <link rel="preconnect" href="//upload.wikimedia.org"> <link rel="alternate" media="only screen and (max-width: 640px)" href="//en.m.wikipedia.org/wiki/Death_receptor_3"> <link rel="alternate" type="application/x-wiki" title="Edit this page" href="/w/index.php?title=Death_receptor_3&action=edit"> <link rel="apple-touch-icon" href="/static/apple-touch/wikipedia.png"> <link rel="icon" href="/static/favicon/wikipedia.ico"> <link rel="search" type="application/opensearchdescription+xml" href="/w/rest.php/v1/search" title="Wikipedia (en)"> <link rel="EditURI" type="application/rsd+xml" href="//en.wikipedia.org/w/api.php?action=rsd"> <link rel="canonical" href="https://en.wikipedia.org/wiki/Death_receptor_3"> <link rel="license" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en"> <link rel="alternate" type="application/atom+xml" title="Wikipedia Atom feed" href="/w/index.php?title=Special:RecentChanges&feed=atom"> <link rel="dns-prefetch" href="//meta.wikimedia.org" /> <link rel="dns-prefetch" href="//login.wikimedia.org"> </head> <body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject mw-editable page-Death_receptor_3 rootpage-Death_receptor_3 skin-vector-2022 action-view"><a class="mw-jump-link" href="#bodyContent">Jump to content</a> <div class="vector-header-container"> <header class="vector-header mw-header"> <div class="vector-header-start"> <nav class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-dropdown" class="vector-dropdown vector-main-menu-dropdown vector-button-flush-left vector-button-flush-right" > <input type="checkbox" id="vector-main-menu-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-main-menu-dropdown" class="vector-dropdown-checkbox " aria-label="Main menu" > <label id="vector-main-menu-dropdown-label" for="vector-main-menu-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-menu mw-ui-icon-wikimedia-menu"></span> <span class="vector-dropdown-label-text">Main menu</span> </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Main menu</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">hide</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Navigation </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Main_Page" title="Visit the main page [z]" accesskey="z"><span>Main page</span></a></li><li id="n-contents" class="mw-list-item"><a href="/wiki/Wikipedia:Contents" title="Guides to browsing Wikipedia"><span>Contents</span></a></li><li id="n-currentevents" class="mw-list-item"><a href="/wiki/Portal:Current_events" title="Articles related to current events"><span>Current events</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Special:Random" title="Visit a randomly selected article [x]" accesskey="x"><span>Random article</span></a></li><li id="n-aboutsite" class="mw-list-item"><a href="/wiki/Wikipedia:About" title="Learn about Wikipedia and how it works"><span>About Wikipedia</span></a></li><li id="n-contactpage" class="mw-list-item"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us" title="How to contact Wikipedia"><span>Contact us</span></a></li> </ul> </div> </div> <div id="p-interaction" class="vector-menu mw-portlet mw-portlet-interaction" > <div class="vector-menu-heading"> Contribute </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-help" class="mw-list-item"><a href="/wiki/Help:Contents" title="Guidance on how to use and edit Wikipedia"><span>Help</span></a></li><li id="n-introduction" class="mw-list-item"><a href="/wiki/Help:Introduction" title="Learn how to edit Wikipedia"><span>Learn to edit</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedia:Community_portal" title="The hub for editors"><span>Community portal</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Special:RecentChanges" title="A list of recent changes to Wikipedia [r]" accesskey="r"><span>Recent changes</span></a></li><li id="n-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_upload_wizard" title="Add images or other media for use on Wikipedia"><span>Upload file</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Main_Page" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedia" src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" style="width: 7.5em; height: 1.125em;"> <img class="mw-logo-tagline" alt="The Free Encyclopedia" src="/static/images/mobile/copyright/wikipedia-tagline-en.svg" width="117" height="13" style="width: 7.3125em; height: 0.8125em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Special:Search" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Search Wikipedia [f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Search</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Search Wikipedia" aria-label="Search Wikipedia" autocapitalize="sentences" title="Search Wikipedia [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Special:Search"> </div> <button class="cdx-button cdx-search-input__end-button">Search</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Personal tools"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Change the appearance of the page's font size, width, and color" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Appearance" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Appearance</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="https://donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_en.wikipedia.org&uselang=en" class=""><span>Donate</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:CreateAccount&returnto=Death+receptor+3" title="You are encouraged to create an account and log in; however, it is not mandatory" class=""><span>Create account</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:UserLogin&returnto=Death+receptor+3" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o" class=""><span>Log in</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Log in and more options" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Personal tools" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Personal tools</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="User menu" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_en.wikipedia.org&uselang=en"><span>Donate</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:CreateAccount&returnto=Death+receptor+3" title="You are encouraged to create an account and log in; however, it is not mandatory"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Create account</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:UserLogin&returnto=Death+receptor+3" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Log in</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Pages for logged out editors <a href="/wiki/Help:Introduction" aria-label="Learn more about editing"><span>learn more</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:MyContributions" title="A list of edits made from this IP address [y]" accesskey="y"><span>Contributions</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:MyTalk" title="Discussion about edits from this IP address [n]" accesskey="n"><span>Talk</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Contents" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Contents</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">hide</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">(Top)</div> </a> </li> <li id="toc-Function" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Function"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Function</span> </div> </a> <ul id="toc-Function-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Therapeutics" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Therapeutics"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Therapeutics</span> </div> </a> <ul id="toc-Therapeutics-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Death receptor 3</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 5 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-5" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">5 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%AF%DB%8C%D8%B1%D9%86%D8%AF%D9%87_%D9%85%D8%B1%DA%AF_%DB%B3" title="گیرنده مرگ ۳ – Persian" lang="fa" hreflang="fa" data-title="گیرنده مرگ ۳" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%A3%BD%EC%9D%8C_%EC%88%98%EC%9A%A9%EC%B2%B4_3" title="죽음 수용체 3 – Korean" lang="ko" hreflang="ko" data-title="죽음 수용체 3" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/TNFRSF25" title="TNFRSF25 – Italian" lang="it" hreflang="it" data-title="TNFRSF25" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/TNFRSF25" title="TNFRSF25 – Tatar" lang="tt" hreflang="tt" data-title="TNFRSF25" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/TNFRSF25" title="TNFRSF25 – Ukrainian" lang="uk" hreflang="uk" data-title="TNFRSF25" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q18033239#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Death_receptor_3" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:Death_receptor_3" rel="discussion" title="Discuss improvements to the content page [t]" accesskey="t"><span>Talk</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Change language variant" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">English</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Views"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Death_receptor_3"><span>Read</span></a></li><li id="ca-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Death_receptor_3&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Death_receptor_3&action=history" title="Past revisions of this page [h]" accesskey="h"><span>View history</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Tools" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Tools</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Tools</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">hide</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="More options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Death_receptor_3"><span>Read</span></a></li><li id="ca-more-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Death_receptor_3&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Death_receptor_3&action=history"><span>View history</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> General </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Special:WhatLinksHere/Death_receptor_3" title="List of all English Wikipedia pages containing links to this page [j]" accesskey="j"><span>What links here</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Special:RecentChangesLinked/Death_receptor_3" rel="nofollow" title="Recent changes in pages linked from this page [k]" accesskey="k"><span>Related changes</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_Upload_Wizard" title="Upload files [u]" accesskey="u"><span>Upload file</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Special:SpecialPages" title="A list of all special pages [q]" accesskey="q"><span>Special pages</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Death_receptor_3&oldid=1215963743" title="Permanent link to this revision of this page"><span>Permanent link</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Death_receptor_3&action=info" title="More information about this page"><span>Page information</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Special:CiteThisPage&page=Death_receptor_3&id=1215963743&wpFormIdentifier=titleform" title="Information on how to cite this page"><span>Cite this page</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Special:UrlShortener&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FDeath_receptor_3"><span>Get shortened URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Special:QrCode&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FDeath_receptor_3"><span>Download QR code</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Print/export </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=Death_receptor_3&action=show-download-screen" title="Download this page as a PDF file"><span>Download as PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Death_receptor_3&printable=yes" title="Printable version of this page [p]" accesskey="p"><span>Printable version</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In other projects </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q18033239" title="Structured data on this page hosted by Wikidata [g]" accesskey="g"><span>Wikidata item</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein found in humans</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">TNFRSF25</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/11910">TNFRSF25</a></span>, APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR, tumor necrosis factor receptor superfamily member 25, TNF receptor superfamily member 25, GEF720, PLEKHG5</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/603366">603366</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1934667">1934667</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=13202">13202</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=TNFRSF25">TNFRSF25</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000215788">TNFRSF25 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_1.svg" class="mw-file-description" title="Chromosome 1 (human)"><img alt="Chromosome 1 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/450px-Ideogram_human_chromosome_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/600px-Ideogram_human_chromosome_1.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_1_(human)" class="mw-redirect" title="Chromosome 1 (human)">Chromosome 1 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_1_ideogram.svg" class="mw-file-description" title="Chromosome 1 (human)"><img alt="Chromosome 1 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/300px-Human_chromosome_1_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/450px-Human_chromosome_1_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/600px-Human_chromosome_1_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 2.2363734155956px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for TNFRSF25"><img alt="Genomic location for TNFRSF25" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 8.2px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for TNFRSF25"><img alt="Genomic location for TNFRSF25" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">1p36.31</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">6,460,786 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">6,466,175 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_4.svg" class="mw-file-description" title="Chromosome 4 (mouse)"><img alt="Chromosome 4 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/260px-Ideogram_house_mouse_chromosome_4.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/390px-Ideogram_house_mouse_chromosome_4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/520px-Ideogram_house_mouse_chromosome_4.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 4 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_4.svg" class="mw-file-description" title="Chromosome 4 (mouse)"><img alt="Chromosome 4 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Ideogram_of_house_mouse_chromosome_4.svg/300px-Ideogram_of_house_mouse_chromosome_4.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Ideogram_of_house_mouse_chromosome_4.svg/450px-Ideogram_of_house_mouse_chromosome_4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Ideogram_of_house_mouse_chromosome_4.svg/600px-Ideogram_of_house_mouse_chromosome_4.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 280.64141857923px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for TNFRSF25"><img alt="Genomic location for TNFRSF25" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 286.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for TNFRSF25"><img alt="Genomic location for TNFRSF25" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">4|4 E2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">152,200,391 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">152,204,576 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000215788">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right hemisphere of cerebellum</li><br /><li style="line-height: 137%;">anterior pituitary</li><br /><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">skin of abdomen</li><br /><li style="line-height: 137%;">skin of leg</li><br /><li style="line-height: 137%;">right frontal lobe</li><br /><li style="line-height: 137%;">right uterine tube</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">mucosa of transverse colon</li><br /><li style="line-height: 137%;">sural nerve</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000024793">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">morula</li><br /><li style="line-height: 137%;">primary visual cortex</li><br /><li style="line-height: 137%;">embryo</li><br /><li style="line-height: 137%;">blastocyst</li><br /><li style="line-height: 137%;">superior frontal gyrus</li><br /><li style="line-height: 137%;">dentate gyrus of hippocampal formation granule cell</li><br /><li style="line-height: 137%;">embryo</li><br /><li style="line-height: 137%;">muscle of thigh</li><br /><li style="line-height: 137%;">yolk sac</li><br /><li style="line-height: 137%;">lens</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000215788">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005031">tumor necrosis factor-activated receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038023">signaling receptor activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042981">regulation of apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007275">multicellular organism development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0097190">apoptotic signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007166">cell surface receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032496">response to lipopolysaccharide</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006954">inflammatory response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033209">tumor necrosis factor-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042127">regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006955">immune response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006915">apoptotic process</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=8718&rn=1">8718</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=85030&rn=1">85030</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000215788;db=core">ENSG00000215788</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000024793;db=core">ENSMUSG00000024793</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q93038">Q93038</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks">n/a</p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_148974">NM_148974</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001039664">NM_001039664</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_003790">NM_003790</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_148965">NM_148965</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_148966">NM_148966</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_148967">NM_148967</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_148968">NM_148968</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_148969">NM_148969</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_148970">NM_148970</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_148971">NM_148971</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_148972">NM_148972</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_148973">NM_148973</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001291010">NM_001291010</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_033042">NM_033042</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001034753">NP_001034753</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_003781">NP_003781</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_683866">NP_683866</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_683867">NP_683867</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_683868">NP_683868</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_683871">NP_683871</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks">n/a</span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr1:6460786-6466175">Chr 1: 6.46 – 6.47 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr4:152200391-152204576">Chr 4: 152.2 – 152.2 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18033239" class="extiw" title="d:Q18033239">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18269920" class="extiw" title="d:Q18269920">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Death receptor 3</b> (<b>DR3</b>), also known as <b>tumor necrosis factor receptor superfamily member 25</b> (<b>TNFRSF25</b>), is a <a href="/wiki/Cell_surface_receptor" title="Cell surface receptor">cell surface receptor</a> of the <a href="/wiki/Tumor_necrosis_factor_receptor" class="mw-redirect" title="Tumor necrosis factor receptor">tumor necrosis factor receptor</a> superfamily which mediates <a href="/wiki/Apoptosis" title="Apoptosis">apoptotic signalling</a> and <a href="/wiki/Cell_differentiation" class="mw-redirect" title="Cell differentiation">differentiation</a>.<sup id="cite_ref-pmid9052839_5-0" class="reference"><a href="#cite_note-pmid9052839-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8934525_6-0" class="reference"><a href="#cite_note-pmid8934525-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_7-0" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Its only known TNFSF ligand is <a href="/wiki/TNF-like_protein_1A" class="mw-redirect" title="TNF-like protein 1A">TNF-like protein 1A</a> (TL1A).<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Death_receptor_3&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially by activated and antigen-experienced T lymphocytes. TNFRSF25 is also highly expressed by FoxP3 positive regulatory T lymphocytes. TNFRSF25 is activated by a monogamous ligand, known as TL1A (TNFSF15), which is rapidly upregulated in antigen presenting cells and some endothelial cells following Toll-Like Receptor or Fc receptor activation. This receptor has been shown to signal both through the <a href="/wiki/TRADD" title="TRADD">TRADD</a> adaptor molecule to stimulate NF-kappa B activity or through the <a href="/wiki/FADD" title="FADD">FADD</a> adaptor molecule to stimulate caspase activation and regulate cell apoptosis.<sup id="cite_ref-pmid8934525_6-1" class="reference"><a href="#cite_note-pmid8934525-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. Specifically, activation of TNFRSF25 is dependent upon previous engagement of the T cell receptor. Following binding to TL1A, TNFRSF25 signaling increases the sensitivity of T cells to endogenous IL-2 via the IL-2 receptor and enhances T cell proliferation. Because the activation of the receptor is T cell receptor dependent, the activity of TNFRSF25 in vivo is specific to those T cells that are encountering cognate antigen. At rest, and for individuals without underlying autoimmunity, the majority of T cells that regularly encounter cognate antigen are FoxP3+ regulatory T cells. Stimulation of TNFRSF25, in the absence of any other exogenous signals, stimulates profound and highly specific proliferation of FoxP3+ regulatory T cells from their 8-10% of all CD4+ T cells to 35-40% of all CD4+ T cells within 5 days.<sup id="cite_ref-Schreiber,_Taylor_H.;_Wolf,_Dietlinde;_Tsai,_Matthew;_et_al._2010_3629–40_9-0" class="reference"><a href="#cite_note-Schreiber,_Taylor_H.;_Wolf,_Dietlinde;_Tsai,_Matthew;_et_al._2010_3629–40-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Therapeutics">Therapeutics</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Death_receptor_3&action=edit&section=2" title="Edit section: Therapeutics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Therapeutic agonists of TNFRSF25 can be used to stimulate <a href="/wiki/Regulatory_T_cell" title="Regulatory T cell">Treg</a> expansion, which can reduce inflammation in experimental models of <a href="/wiki/Asthma" title="Asthma">asthma</a>, <a href="/wiki/Allotransplantation" title="Allotransplantation">allogeneic solid organ transplantation</a> and ocular <a href="/wiki/Keratitis" title="Keratitis">keratitis</a>.<sup id="cite_ref-Schreiber,_Taylor_H.;_Wolf,_Dietlinde;_Tsai,_Matthew;_et_al._2010_3629–40_9-1" class="reference"><a href="#cite_note-Schreiber,_Taylor_H.;_Wolf,_Dietlinde;_Tsai,_Matthew;_et_al._2010_3629–40-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Similarly, because TNFRSF25 activation is antigen dependent, costimulation of TNFRSF25 together with an autoantigen or with a vaccine antigen can lead to exacerbation of immunopathology or enhanced vaccine-stimulated immunity, respectively.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> TNFRSF25 stimulation is therefore highly specific to T cell mediated immunity, which can be used to enhance or dampen inflammation depending on the temporal context and quality of foreign vs self antigen availability. Stimulation of TNFRSF25 in humans may lead to similar, but more controllable, effects as coinhibitory receptor blockade targeting molecules such as <a href="/wiki/CTLA-4" class="mw-redirect" title="CTLA-4">CTLA-4</a> and <a href="/wiki/PD-1" class="mw-redirect" title="PD-1">PD-1</a>.<sup id="cite_ref-entrez_7-1" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Death_receptor_3&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000215788">GRCh38: Ensembl release 89: ENSG00000215788</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000024793">GRCm38: Ensembl release 89: ENSMUSG00000024793</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=8718">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D8718&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=85030">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D85030&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></span> </li> <li id="cite_note-pmid9052839-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid9052839_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBodmerBurnsSchneiderHofmann1997" class="citation journal cs1">Bodmer JL, Burns K, Schneider P, Hofmann K, Steiner V, Thome M, Bornand T, Hahne M, Schröter M, Becker K, Wilson A, French LE, Browning JL, MacDonald HR, Tschopp J (Jan 1997). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1074-7613%2800%2980244-7">"TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)"</a>. <i>Immunity</i>. <b>6</b> (1): 79–88. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1074-7613%2800%2980244-7">10.1016/S1074-7613(00)80244-7</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9052839">9052839</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Immunity&rft.atitle=TRAMP%2C+a+novel+apoptosis-mediating+receptor+with+sequence+homology+to+tumor+necrosis+factor+receptor+1+and+Fas%28Apo-1%2FCD95%29&rft.volume=6&rft.issue=1&rft.pages=79-88&rft.date=1997-01&rft_id=info%3Adoi%2F10.1016%2FS1074-7613%2800%2980244-7&rft_id=info%3Apmid%2F9052839&rft.aulast=Bodmer&rft.aufirst=JL&rft.au=Burns%2C+K&rft.au=Schneider%2C+P&rft.au=Hofmann%2C+K&rft.au=Steiner%2C+V&rft.au=Thome%2C+M&rft.au=Bornand%2C+T&rft.au=Hahne%2C+M&rft.au=Schr%C3%B6ter%2C+M&rft.au=Becker%2C+K&rft.au=Wilson%2C+A&rft.au=French%2C+LE&rft.au=Browning%2C+JL&rft.au=MacDonald%2C+HR&rft.au=Tschopp%2C+J&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS1074-7613%252800%252980244-7&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></span> </li> <li id="cite_note-pmid8934525-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid8934525_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid8934525_6-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKitsonRavenJiangGoeddel1996" class="citation journal cs1">Kitson J, Raven T, Jiang YP, Goeddel DV, Giles KM, Pun KT, Grinham CJ, Brown R, Farrow SN (Nov 1996). "A death-domain-containing receptor that mediates apoptosis". <i>Nature</i>. <b>384</b> (6607): 372–5. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1996Natur.384..372K">1996Natur.384..372K</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F384372a0">10.1038/384372a0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8934525">8934525</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4283742">4283742</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=A+death-domain-containing+receptor+that+mediates+apoptosis&rft.volume=384&rft.issue=6607&rft.pages=372-5&rft.date=1996-11&rft_id=info%3Adoi%2F10.1038%2F384372a0&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4283742%23id-name%3DS2CID&rft_id=info%3Apmid%2F8934525&rft_id=info%3Abibcode%2F1996Natur.384..372K&rft.aulast=Kitson&rft.aufirst=J&rft.au=Raven%2C+T&rft.au=Jiang%2C+YP&rft.au=Goeddel%2C+DV&rft.au=Giles%2C+KM&rft.au=Pun%2C+KT&rft.au=Grinham%2C+CJ&rft.au=Brown%2C+R&rft.au=Farrow%2C+SN&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></span> </li> <li id="cite_note-entrez-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-entrez_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-entrez_7-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8718">"Entrez Gene: TNFRSF25 tumor necrosis factor receptor superfamily, member 25"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+TNFRSF25+tumor+necrosis+factor+receptor+superfamily%2C+member+25&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3FDb%3Dgene%26Cmd%3DShowDetailView%26TermToSearch%3D8718&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWang2012" class="citation journal cs1">Wang EC (Sep 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449252">"On death receptor 3 and its ligands…"</a>. <i>Immunology</i>. <b>137</b> (1): 114–6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-2567.2012.03606.x">10.1111/j.1365-2567.2012.03606.x</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449252">3449252</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22612445">22612445</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=On+death+receptor+3+and+its+ligands%E2%80%A6&rft.volume=137&rft.issue=1&rft.pages=114-6&rft.date=2012-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3449252%23id-name%3DPMC&rft_id=info%3Apmid%2F22612445&rft_id=info%3Adoi%2F10.1111%2Fj.1365-2567.2012.03606.x&rft.aulast=Wang&rft.aufirst=EC&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3449252&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></span> </li> <li id="cite_note-Schreiber,_Taylor_H.;_Wolf,_Dietlinde;_Tsai,_Matthew;_et_al._2010_3629–40-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-Schreiber,_Taylor_H.;_Wolf,_Dietlinde;_Tsai,_Matthew;_et_al._2010_3629–40_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Schreiber,_Taylor_H.;_Wolf,_Dietlinde;_Tsai,_Matthew;_et_al._2010_3629–40_9-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSchreiberWolfTsaiChirinos2010" class="citation journal cs1">Schreiber TH, Wolf D, Tsai MS, Chirinos J, Deyev VV, Gonzalez L, Malek TR, Levy RB, Podack ER (Oct 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947231">"Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation"</a>. <i>The Journal of Clinical Investigation</i>. <b>120</b> (10): 3629–40. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1172%2FJCI42933">10.1172/JCI42933</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947231">2947231</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20890040">20890040</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Clinical+Investigation&rft.atitle=Therapeutic+Treg+expansion+in+mice+by+TNFRSF25+prevents+allergic+lung+inflammation&rft.volume=120&rft.issue=10&rft.pages=3629-40&rft.date=2010-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2947231%23id-name%3DPMC&rft_id=info%3Apmid%2F20890040&rft_id=info%3Adoi%2F10.1172%2FJCI42933&rft.aulast=Schreiber&rft.aufirst=TH&rft.au=Wolf%2C+D&rft.au=Tsai%2C+MS&rft.au=Chirinos%2C+J&rft.au=Deyev%2C+VV&rft.au=Gonzalez%2C+L&rft.au=Malek%2C+TR&rft.au=Levy%2C+RB&rft.au=Podack%2C+ER&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2947231&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJ_ReddySchreiberRajasagiSuryawanshi2012" class="citation journal cs1">J Reddy PB, Schreiber TH, Rajasagi NK, Suryawanshi A, Mulik S, Veiga-Parga T, Niki T, Hirashima M, Podack ER, Rouse BT (Oct 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457251">"TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions"</a>. <i>Journal of Virology</i>. <b>86</b> (19): 10606–20. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FJVI.01391-12">10.1128/JVI.01391-12</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457251">3457251</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22811539">22811539</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=TNFRSF25+agonistic+antibody+and+galectin-9+combination+therapy+controls+herpes+simplex+virus-induced+immunoinflammatory+lesions&rft.volume=86&rft.issue=19&rft.pages=10606-20&rft.date=2012-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3457251%23id-name%3DPMC&rft_id=info%3Apmid%2F22811539&rft_id=info%3Adoi%2F10.1128%2FJVI.01391-12&rft.aulast=J+Reddy&rft.aufirst=PB&rft.au=Schreiber%2C+TH&rft.au=Rajasagi%2C+NK&rft.au=Suryawanshi%2C+A&rft.au=Mulik%2C+S&rft.au=Veiga-Parga%2C+T&rft.au=Niki%2C+T&rft.au=Hirashima%2C+M&rft.au=Podack%2C+ER&rft.au=Rouse%2C+BT&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3457251&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWolfSchreiberTryphonopoulosLi2012" class="citation journal cs1">Wolf D, Schreiber TH, Tryphonopoulos P, Li S, Tzakis AG, Ruiz P, Podack ER (Sep 2012). <a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FTP.0b013e318264d3ef">"Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival"</a>. <i>Transplantation</i>. <b>94</b> (6): 569–74. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FTP.0b013e318264d3ef">10.1097/TP.0b013e318264d3ef</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22902792">22902792</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:19548386">19548386</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Tregs+expanded+in+vivo+by+TNFRSF25+agonists+promote+cardiac+allograft+survival&rft.volume=94&rft.issue=6&rft.pages=569-74&rft.date=2012-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A19548386%23id-name%3DS2CID&rft_id=info%3Apmid%2F22902792&rft_id=info%3Adoi%2F10.1097%2FTP.0b013e318264d3ef&rft.aulast=Wolf&rft.aufirst=D&rft.au=Schreiber%2C+TH&rft.au=Tryphonopoulos%2C+P&rft.au=Li%2C+S&rft.au=Tzakis%2C+AG&rft.au=Ruiz%2C+P&rft.au=Podack%2C+ER&rft_id=https%3A%2F%2Fdoi.org%2F10.1097%252FTP.0b013e318264d3ef&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-12">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSchreiberWolfBoderoGonzalez2012" class="citation journal cs1">Schreiber TH, Wolf D, Bodero M, Gonzalez L, Podack ER (Oct 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449097">"T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination"</a>. <i>Journal of Immunology</i>. <b>189</b> (7): 3311–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4049%2Fjimmunol.1200597">10.4049/jimmunol.1200597</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449097">3449097</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22956587">22956587</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=T+cell+costimulation+by+TNFR+superfamily+%28TNFRSF%294+and+TNFRSF25+in+the+context+of+vaccination&rft.volume=189&rft.issue=7&rft.pages=3311-8&rft.date=2012-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3449097%23id-name%3DPMC&rft_id=info%3Apmid%2F22956587&rft_id=info%3Adoi%2F10.4049%2Fjimmunol.1200597&rft.aulast=Schreiber&rft.aufirst=TH&rft.au=Wolf%2C+D&rft.au=Bodero%2C+M&rft.au=Gonzalez%2C+L&rft.au=Podack%2C+ER&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3449097&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Death_receptor_3&action=edit&section=4" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMetheny-BarlowLi2006" class="citation journal cs1">Metheny-Barlow LJ, Li LY (2006). "Vascular endothelial growth inhibitor (VEGI), an endogenous negative regulator of angiogenesis". <i>Seminars in Ophthalmology</i>. <b>21</b> (1): 49–58. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F08820530500511446">10.1080/08820530500511446</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16517446">16517446</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:41728328">41728328</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Seminars+in+Ophthalmology&rft.atitle=Vascular+endothelial+growth+inhibitor+%28VEGI%29%2C+an+endogenous+negative+regulator+of+angiogenesis&rft.volume=21&rft.issue=1&rft.pages=49-58&rft.date=2006&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A41728328%23id-name%3DS2CID&rft_id=info%3Apmid%2F16517446&rft_id=info%3Adoi%2F10.1080%2F08820530500511446&rft.aulast=Metheny-Barlow&rft.aufirst=LJ&rft.au=Li%2C+LY&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFChinnaiyanO'RourkeYuLyons1996" class="citation journal cs1">Chinnaiyan AM, O'Rourke K, Yu GL, Lyons RH, Garg M, Duan DR, Xing L, Gentz R, Ni J, Dixit VM (Nov 1996). "Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95". <i>Science</i>. <b>274</b> (5289): 990–2. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1996Sci...274..990C">1996Sci...274..990C</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.274.5289.990">10.1126/science.274.5289.990</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8875942">8875942</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:2348299">2348299</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science&rft.atitle=Signal+transduction+by+DR3%2C+a+death+domain-containing+receptor+related+to+TNFR-1+and+CD95&rft.volume=274&rft.issue=5289&rft.pages=990-2&rft.date=1996-11&rft_id=info%3Adoi%2F10.1126%2Fscience.274.5289.990&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A2348299%23id-name%3DS2CID&rft_id=info%3Apmid%2F8875942&rft_id=info%3Abibcode%2F1996Sci...274..990C&rft.aulast=Chinnaiyan&rft.aufirst=AM&rft.au=O%27Rourke%2C+K&rft.au=Yu%2C+GL&rft.au=Lyons%2C+RH&rft.au=Garg%2C+M&rft.au=Duan%2C+DR&rft.au=Xing%2C+L&rft.au=Gentz%2C+R&rft.au=Ni%2C+J&rft.au=Dixit%2C+VM&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBonaldoLennonSoares1996" class="citation journal cs1">Bonaldo MF, Lennon G, Soares MB (Sep 1996). <a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.6.9.791">"Normalization and subtraction: two approaches to facilitate gene discovery"</a>. <i>Genome Research</i>. <b>6</b> (9): 791–806. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.6.9.791">10.1101/gr.6.9.791</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8889548">8889548</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=Normalization+and+subtraction%3A+two+approaches+to+facilitate+gene+discovery&rft.volume=6&rft.issue=9&rft.pages=791-806&rft.date=1996-09&rft_id=info%3Adoi%2F10.1101%2Fgr.6.9.791&rft_id=info%3Apmid%2F8889548&rft.aulast=Bonaldo&rft.aufirst=MF&rft.au=Lennon%2C+G&rft.au=Soares%2C+MB&rft_id=https%3A%2F%2Fdoi.org%2F10.1101%252Fgr.6.9.791&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMarstersSheridanDonahuePitti1996" class="citation journal cs1">Marsters SA, Sheridan JP, Donahue CJ, Pitti RM, Gray CL, Goddard AD, Bauer KD, Ashkenazi A (Dec 1996). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0960-9822%2802%2970791-4">"Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B"</a>. <i>Current Biology</i>. <b>6</b> (12): 1669–76. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1996CBio....6.1669M">1996CBio....6.1669M</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0960-9822%2802%2970791-4">10.1016/S0960-9822(02)70791-4</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8994832">8994832</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:16088373">16088373</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Biology&rft.atitle=Apo-3%2C+a+new+member+of+the+tumor+necrosis+factor+receptor+family%2C+contains+a+death+domain+and+activates+apoptosis+and+NF-kappa+B&rft.volume=6&rft.issue=12&rft.pages=1669-76&rft.date=1996-12&rft_id=info%3Adoi%2F10.1016%2FS0960-9822%2802%2970791-4&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A16088373%23id-name%3DS2CID&rft_id=info%3Apmid%2F8994832&rft_id=info%3Abibcode%2F1996CBio....6.1669M&rft.aulast=Marsters&rft.aufirst=SA&rft.au=Sheridan%2C+JP&rft.au=Donahue%2C+CJ&rft.au=Pitti%2C+RM&rft.au=Gray%2C+CL&rft.au=Goddard%2C+AD&rft.au=Bauer%2C+KD&rft.au=Ashkenazi%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0960-9822%252802%252970791-4&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFScreatonXuOlsenCowper1997" class="citation journal cs1">Screaton GR, Xu XN, Olsen AL, Cowper AE, Tan R, McMichael AJ, Bell JI (Apr 1997). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20772">"LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>94</b> (9): 4615–9. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1997PNAS...94.4615S">1997PNAS...94.4615S</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.94.9.4615">10.1073/pnas.94.9.4615</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20772">20772</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9114039">9114039</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=LARD%3A+a+new+lymphoid-specific+death+domain+containing+receptor+regulated+by+alternative+pre-mRNA+splicing&rft.volume=94&rft.issue=9&rft.pages=4615-9&rft.date=1997-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC20772%23id-name%3DPMC&rft_id=info%3Apmid%2F9114039&rft_id=info%3Adoi%2F10.1073%2Fpnas.94.9.4615&rft_id=info%3Abibcode%2F1997PNAS...94.4615S&rft.aulast=Screaton&rft.aufirst=GR&rft.au=Xu%2C+XN&rft.au=Olsen%2C+AL&rft.au=Cowper%2C+AE&rft.au=Tan%2C+R&rft.au=McMichael%2C+AJ&rft.au=Bell%2C+JI&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC20772&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWarzochaRibeiroCharlotRenard1998" class="citation journal cs1">Warzocha K, Ribeiro P, Charlot C, Renard N, Coiffier B, Salles G (Jan 1998). "A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas". <i>Biochemical and Biophysical Research Communications</i>. <b>242</b> (2): 376–9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.1997.7948">10.1006/bbrc.1997.7948</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9446802">9446802</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=A+new+death+receptor+3+isoform%3A+expression+in+human+lymphoid+cell+lines+and+non-Hodgkin%27s+lymphomas&rft.volume=242&rft.issue=2&rft.pages=376-9&rft.date=1998-01&rft_id=info%3Adoi%2F10.1006%2Fbbrc.1997.7948&rft_id=info%3Apmid%2F9446802&rft.aulast=Warzocha&rft.aufirst=K&rft.au=Ribeiro%2C+P&rft.au=Charlot%2C+C&rft.au=Renard%2C+N&rft.au=Coiffier%2C+B&rft.au=Salles%2C+G&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGrenetValentineKitsonLi1998" class="citation journal cs1">Grenet J, Valentine V, Kitson J, Li H, Farrow SN, Kidd VJ (May 1998). "Duplication of the DR3 gene on human chromosome 1p36 and its deletion in human neuroblastoma". <i>Genomics</i>. <b>49</b> (3): 385–93. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fgeno.1998.5300">10.1006/geno.1998.5300</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9615223">9615223</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Duplication+of+the+DR3+gene+on+human+chromosome+1p36+and+its+deletion+in+human+neuroblastoma&rft.volume=49&rft.issue=3&rft.pages=385-93&rft.date=1998-05&rft_id=info%3Adoi%2F10.1006%2Fgeno.1998.5300&rft_id=info%3Apmid%2F9615223&rft.aulast=Grenet&rft.aufirst=J&rft.au=Valentine%2C+V&rft.au=Kitson%2C+J&rft.au=Li%2C+H&rft.au=Farrow%2C+SN&rft.au=Kidd%2C+VJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJiangWoroniczLiuGoeddel1999" class="citation journal cs1">Jiang Y, Woronicz JD, Liu W, Goeddel DV (Jan 1999). "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains". <i>Science</i>. <b>283</b> (5401): 543–6. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1999Sci...283..543J">1999Sci...283..543J</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.283.5401.543">10.1126/science.283.5401.543</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9915703">9915703</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science&rft.atitle=Prevention+of+constitutive+TNF+receptor+1+signaling+by+silencer+of+death+domains&rft.volume=283&rft.issue=5401&rft.pages=543-6&rft.date=1999-01&rft_id=info%3Apmid%2F9915703&rft_id=info%3Adoi%2F10.1126%2Fscience.283.5401.543&rft_id=info%3Abibcode%2F1999Sci...283..543J&rft.aulast=Jiang&rft.aufirst=Y&rft.au=Woronicz%2C+JD&rft.au=Liu%2C+W&rft.au=Goeddel%2C+DV&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKapteinJansenDilaverKitson2000" class="citation journal cs1">Kaptein A, Jansen M, Dilaver G, Kitson J, Dash L, Wang E, Owen MJ, Bodmer JL, Tschopp J, Farrow SN (Nov 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0014-5793%2800%2902219-5">"Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)"</a>. <i>FEBS Letters</i>. <b>485</b> (2–3): 135–41. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0014-5793%2800%2902219-5">10.1016/S0014-5793(00)02219-5</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11094155">11094155</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Studies+on+the+interaction+between+TWEAK+and+the+death+receptor+WSL-1%2FTRAMP+%28DR3%29&rft.volume=485&rft.issue=2%E2%80%933&rft.pages=135-41&rft.date=2000-11&rft_id=info%3Adoi%2F10.1016%2FS0014-5793%2800%2902219-5&rft_id=info%3Apmid%2F11094155&rft.aulast=Kaptein&rft.aufirst=A&rft.au=Jansen%2C+M&rft.au=Dilaver%2C+G&rft.au=Kitson%2C+J&rft.au=Dash%2C+L&rft.au=Wang%2C+E&rft.au=Owen%2C+MJ&rft.au=Bodmer%2C+JL&rft.au=Tschopp%2C+J&rft.au=Farrow%2C+SN&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0014-5793%252800%252902219-5&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFrankelVan_LindenRiches2001" class="citation journal cs1">Frankel SK, Van Linden AA, Riches DW (Oct 2001). "Heterogeneity in the phosphorylation of human death receptors by p42(mapk/erk2)". <i>Biochemical and Biophysical Research Communications</i>. <b>288</b> (2): 313–20. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.2001.5761">10.1006/bbrc.2001.5761</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11606045">11606045</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Heterogeneity+in+the+phosphorylation+of+human+death+receptors+by+p42%28mapk%2Ferk2%29&rft.volume=288&rft.issue=2&rft.pages=313-20&rft.date=2001-10&rft_id=info%3Adoi%2F10.1006%2Fbbrc.2001.5761&rft_id=info%3Apmid%2F11606045&rft.aulast=Frankel&rft.aufirst=SK&rft.au=Van+Linden%2C+AA&rft.au=Riches%2C+DW&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMigoneZhangLuoZhuang2002" class="citation journal cs1">Migone TS, Zhang J, Luo X, Zhuang L, Chen C, Hu B, Hong JS, Perry JW, Chen SF, Zhou JX, Cho YH, Ullrich S, Kanakaraj P, Carrell J, Boyd E, Olsen HS, Hu G, Pukac L, Liu D, Ni J, Kim S, Gentz R, Feng P, Moore PA, Ruben SM, Wei P (Mar 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1074-7613%2802%2900283-2">"TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator"</a>. <i>Immunity</i>. <b>16</b> (3): 479–92. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1074-7613%2802%2900283-2">10.1016/S1074-7613(02)00283-2</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11911831">11911831</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Immunity&rft.atitle=TL1A+is+a+TNF-like+ligand+for+DR3+and+TR6%2FDcR3+and+functions+as+a+T+cell+costimulator&rft.volume=16&rft.issue=3&rft.pages=479-92&rft.date=2002-03&rft_id=info%3Adoi%2F10.1016%2FS1074-7613%2802%2900283-2&rft_id=info%3Apmid%2F11911831&rft.aulast=Migone&rft.aufirst=TS&rft.au=Zhang%2C+J&rft.au=Luo%2C+X&rft.au=Zhuang%2C+L&rft.au=Chen%2C+C&rft.au=Hu%2C+B&rft.au=Hong%2C+JS&rft.au=Perry%2C+JW&rft.au=Chen%2C+SF&rft.au=Zhou%2C+JX&rft.au=Cho%2C+YH&rft.au=Ullrich%2C+S&rft.au=Kanakaraj%2C+P&rft.au=Carrell%2C+J&rft.au=Boyd%2C+E&rft.au=Olsen%2C+HS&rft.au=Hu%2C+G&rft.au=Pukac%2C+L&rft.au=Liu%2C+D&rft.au=Ni%2C+J&rft.au=Kim%2C+S&rft.au=Gentz%2C+R&rft.au=Feng%2C+P&rft.au=Moore%2C+PA&rft.au=Ruben%2C+SM&rft.au=Wei%2C+P&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS1074-7613%252802%252900283-2&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAl-LamkiWangThiruPritchard2003" class="citation journal cs1">Al-Lamki RS, Wang J, Thiru S, Pritchard NR, Bradley JA, Pober JS, Bradley JR (Aug 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868232">"Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants"</a>. <i>The American Journal of Pathology</i>. <b>163</b> (2): 401–11. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0002-9440%2810%2963670-X">10.1016/S0002-9440(10)63670-X</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868232">1868232</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12875962">12875962</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+American+Journal+of+Pathology&rft.atitle=Expression+of+silencer+of+death+domains+and+death-receptor-3+in+normal+human+kidney+and+in+rejecting+renal+transplants&rft.volume=163&rft.issue=2&rft.pages=401-11&rft.date=2003-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1868232%23id-name%3DPMC&rft_id=info%3Apmid%2F12875962&rft_id=info%3Adoi%2F10.1016%2FS0002-9440%2810%2963670-X&rft.aulast=Al-Lamki&rft.aufirst=RS&rft.au=Wang%2C+J&rft.au=Thiru%2C+S&rft.au=Pritchard%2C+NR&rft.au=Bradley%2C+JA&rft.au=Pober%2C+JS&rft.au=Bradley%2C+JR&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1868232&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWenZhuangLuoWei2003" class="citation journal cs1">Wen L, Zhuang L, Luo X, Wei P (Oct 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M305833200">"TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells"</a>. <i>The Journal of Biological Chemistry</i>. <b>278</b> (40): 39251–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M305833200">10.1074/jbc.M305833200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12882979">12882979</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=TL1A-induced+NF-kappaB+activation+and+c-IAP2+production+prevent+DR3-mediated+apoptosis+in+TF-1+cells&rft.volume=278&rft.issue=40&rft.pages=39251-8&rft.date=2003-10&rft_id=info%3Adoi%2F10.1074%2Fjbc.M305833200&rft_id=info%3Apmid%2F12882979&rft.aulast=Wen&rft.aufirst=L&rft.au=Zhuang%2C+L&rft.au=Luo%2C+X&rft.au=Wei%2C+P&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M305833200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHillmanGreenBrenner2005" class="citation journal cs1">Hillman RT, Green RE, Brenner SE (2005). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395752">"An unappreciated role for RNA surveillance"</a>. <i>Genome Biology</i>. <b>5</b> (2): R8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2Fgb-2004-5-2-r8">10.1186/gb-2004-5-2-r8</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395752">395752</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14759258">14759258</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genome+Biology&rft.atitle=An+unappreciated+role+for+RNA+surveillance&rft.volume=5&rft.issue=2&rft.pages=R8&rft.date=2005&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC395752%23id-name%3DPMC&rft_id=info%3Apmid%2F14759258&rft_id=info%3Adoi%2F10.1186%2Fgb-2004-5-2-r8&rft.aulast=Hillman&rft.aufirst=RT&rft.au=Green%2C+RE&rft.au=Brenner%2C+SE&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC395752&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOsawaTakamiShiozawaHashiramoto2004" class="citation journal cs1">Osawa K, Takami N, Shiozawa K, Hashiramoto A, Shiozawa S (Sep 2004). "Death receptor 3 (DR3) gene duplication in a chromosome region 1p36.3: gene duplication is more prevalent in rheumatoid arthritis". <i>Genes and Immunity</i>. <b>5</b> (6): 439–43. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.gene.6364097">10.1038/sj.gene.6364097</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15241467">15241467</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:7357230">7357230</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes+and+Immunity&rft.atitle=Death+receptor+3+%28DR3%29+gene+duplication+in+a+chromosome+region+1p36.3%3A+gene+duplication+is+more+prevalent+in+rheumatoid+arthritis&rft.volume=5&rft.issue=6&rft.pages=439-43&rft.date=2004-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A7357230%23id-name%3DS2CID&rft_id=info%3Apmid%2F15241467&rft_id=info%3Adoi%2F10.1038%2Fsj.gene.6364097&rft.aulast=Osawa&rft.aufirst=K&rft.au=Takami%2C+N&rft.au=Shiozawa%2C+K&rft.au=Hashiramoto%2C+A&rft.au=Shiozawa%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADeath+receptor+3" class="Z3988"></span></li></ul> </div> <p><i>This article incorporates text from the <a href="/wiki/United_States_National_Library_of_Medicine" title="United States National Library of Medicine">United States National Library of Medicine</a>, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</i> </p> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox,.mw-parser-output .navbox-subgroup{background-color:#fdfdfd}.mw-parser-output .navbox-list{line-height:1.5em;border-color:#fdfdfd}.mw-parser-output .navbox-list-with-group{text-align:left;border-left-width:2px;border-left-style:solid}.mw-parser-output tr+tr>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Cytokine_receptors" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cytokine_receptors" title="Template:Cytokine receptors"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cytokine_receptors" title="Template talk:Cytokine receptors"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cytokine_receptors" title="Special:EditPage/Template:Cytokine receptors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cytokine_receptors" style="font-size:114%;margin:0 4em"><a href="/wiki/Cytokine_receptor" title="Cytokine receptor">Cytokine receptors</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Chemokine_receptor" title="Chemokine receptor">Chemokine receptor</a><br />(<a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">GPCRs</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CC_chemokine_receptors" title="CC chemokine receptors">CC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CCR1" title="CCR1">CCR1</a> / <a href="/wiki/CCRL1" title="CCRL1">CCRL1</a></li> <li><a href="/wiki/CCR2" title="CCR2">CCR2</a></li> <li><a href="/wiki/CCRL2" title="CCRL2">CCRL2</a></li> <li><a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CCR3</a></li> <li><a href="/wiki/CCR4" title="CCR4">CCR4</a></li> <li><a href="/wiki/CCR5" title="CCR5">CCR5</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_6" title="C-C chemokine receptor type 6">CCR6</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_7" title="C-C chemokine receptor type 7">CCR7</a></li> <li><a href="/wiki/CCR8_(gene)" title="CCR8 (gene)">CCR8</a></li> <li><a href="/wiki/CCR9" title="CCR9">CCR9</a></li> <li><a href="/wiki/CCR10" title="CCR10">CCR10</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CXC_chemokine_receptors" title="CXC chemokine receptors">CXC</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin-8_receptor" title="Interleukin-8 receptor">IL-8</a> <ul><li><a href="/wiki/Interleukin_8_receptor,_alpha" title="Interleukin 8 receptor, alpha">CXCR1</a></li> <li><a href="/wiki/Interleukin_8_receptor,_beta" title="Interleukin 8 receptor, beta">CXCR2</a></li></ul></li> <li><a href="/wiki/CXCR3" title="CXCR3">CXCR3</a></li> <li><a href="/wiki/CXCR4" title="CXCR4">CXCR4</a></li> <li><a href="/wiki/CXCR5" title="CXCR5">CXCR5</a></li> <li><a href="/wiki/CXCR6" title="CXCR6">CXCR6</a></li> <li><a href="/wiki/ACKR3" title="ACKR3">CXCR7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>CX3C <ul><li><a href="/wiki/CX3C_motif_chemokine_receptor_1" title="CX3C motif chemokine receptor 1">CX3CR1</a></li></ul></li> <li>XC <ul><li><a href="/wiki/XCR1" title="XCR1">XCR1</a></li></ul></li> <li><a href="/wiki/CCBP2" title="CCBP2">CCBP2</a></li> <li><a href="/wiki/CMKLR1" title="CMKLR1">CMKLR1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Tumor_necrosis_factor_receptor" class="mw-redirect" title="Tumor necrosis factor receptor">TNF receptor</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">1-10</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tumor_necrosis_factor_receptor_1" title="Tumor necrosis factor receptor 1">TNFR1</a> <i>(TNFRSF1A)</i></li> <li><a href="/wiki/Tumor_necrosis_factor_receptor_2" title="Tumor necrosis factor receptor 2">TNFR2</a> <i>(TNFRSF1B)</i></li> <li><a href="/wiki/Lymphotoxin_beta_receptor" title="Lymphotoxin beta receptor">LTBR</a> <i>(TNFRSF3)</i></li> <li><a href="/wiki/CD134" title="CD134">CD134</a> <i>(TNFRSF4)</i></li> <li><a href="/wiki/CD40_(protein)" title="CD40 (protein)">CD40</a> <i>(TNFRSF5)</i></li> <li><a href="/wiki/Fas_receptor" title="Fas receptor">Fas receptor</a> <i>(TNFRSF6)</i></li> <li><a href="/wiki/DcR3" class="mw-redirect" title="DcR3">DcR3</a> <i>(TNFRSF6B)</i></li> <li><a href="/wiki/CD27" title="CD27">CD27</a> <i>(TNFRSF7)</i></li> <li><a href="/wiki/CD30" title="CD30">CD30</a> <i>(TNFRSF8)</i></li> <li><a href="/wiki/CD137" title="CD137">CD137</a> <i>(TNFRSF9)</i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">11-20</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Death_receptor_4" title="Death receptor 4">DR4</a> <i>(TNFRSF10A)</i></li> <li><a href="/wiki/Death_receptor_5" title="Death receptor 5">DR5</a> <i>(TNFRSF10B)</i></li> <li><a href="/wiki/Decoy_receptor_1" title="Decoy receptor 1">DcR1</a> <i>(TNFRSF10C)</i></li> <li><a href="/wiki/Decoy_receptor_2" title="Decoy receptor 2">DcR2</a> <i>(TNFRSF10D)</i></li> <li><a href="/wiki/RANK" title="RANK">RANK</a> <i>(TNFRSF11A)</i></li> <li><a href="/wiki/Osteoprotegerin" title="Osteoprotegerin">Osteoprotegerin</a> <i>(TNFRSF11B)</i></li> <li><a href="/wiki/TNFRSF12A" title="TNFRSF12A">TweakR</a> <i>(TNFRSF12A)</i></li> <li><a href="/wiki/TNFRSF13B" class="mw-redirect" title="TNFRSF13B">TACI</a> <i>(TNFRSF13B)</i></li> <li><a href="/wiki/TNFRSF13C" class="mw-redirect" title="TNFRSF13C">BAFFR</a> <i>(TNFRSF13C)</i></li> <li><a href="/wiki/TNFRSF14" class="mw-redirect" title="TNFRSF14">HVEM</a> <i>(TNFRSF14)</i></li> <li><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">NGFR</a> <i>(TNFRSF16)</i></li> <li><a href="/wiki/TNFRSF17" class="mw-redirect" title="TNFRSF17">BCMA</a> <i>(TNFRSF17)</i></li> <li><a href="/wiki/TNFRSF18" title="TNFRSF18">GITR</a> <i>(TNFRSF18)</i></li> <li><a href="/wiki/TNFRSF19" title="TNFRSF19">TAJ/TROY</a> <i>(TNFRSF19)</i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">21-27</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Death_receptor_6" title="Death receptor 6">DR6</a> <i>(TNFRSF21)</i></li> <li><a class="mw-selflink selflink">DR3</a> <i>(TNFRSF25)</i></li> <li><a href="/wiki/Ectodysplasin_A2_receptor" title="Ectodysplasin A2 receptor">EDA2R</a> <i>(TNFRSF27)</i></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/JAK-STAT_signaling_pathway" title="JAK-STAT signaling pathway">JAK-STAT</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Type_I_cytokine_receptor" title="Type I cytokine receptor">Type I</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Common_gamma_chain" title="Common gamma chain">γ-chain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/IL-2_receptor" title="IL-2 receptor">IL2R</a> / <a href="/wiki/IL2RA" title="IL2RA">IL2RA</a>/<a href="/wiki/IL2RB" title="IL2RB">IL2RB</a> / <a href="/wiki/Interleukin-15_receptor" title="Interleukin-15 receptor">IL15R</a></li> <li><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">IL4R</a> / <a href="/wiki/Interleukin-13_receptor" title="Interleukin-13 receptor">IL13R</a> / <a href="/wiki/Interleukin_13_receptor,_alpha_1" title="Interleukin 13 receptor, alpha 1">IL13RA1</a> / <a href="/wiki/IL13RA2" title="IL13RA2">IL13RA2</a></li> <li><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">IL7R</a> / <a href="/wiki/Interleukin-7_receptor-%CE%B1" title="Interleukin-7 receptor-α">IL7RA</a></li> <li><a href="/wiki/Interleukin-9_receptor" title="Interleukin-9 receptor">IL9R</a></li> <li><a href="/wiki/Interleukin-21_receptor" title="Interleukin-21 receptor">IL21R</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CSF2RB" title="CSF2RB">β-chain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-3_receptor" title="Interleukin-3 receptor">IL3R</a> / <a href="/wiki/IL3RA" title="IL3RA">IL3RA</a></li> <li><a href="/wiki/Interleukin-5_receptor" title="Interleukin-5 receptor">IL5R</a> / <a href="/wiki/Interleukin_5_receptor_alpha_subunit" title="Interleukin 5 receptor alpha subunit">IL5RA</a></li></ul></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">GM-CSF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">gp130</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">IL6RA</a></li> <li><a href="/wiki/Interleukin-11_receptor" title="Interleukin-11 receptor">11</a>/<a href="/wiki/Interleukin_11_receptor_alpha_subunit" title="Interleukin 11 receptor alpha subunit">IL11RA</a></li> <li><a href="/wiki/Interleukin-27_receptor" title="Interleukin-27 receptor">27</a>/<a href="/wiki/Interleukin_27_receptor,_alpha_subunit" title="Interleukin 27 receptor, alpha subunit">IL27RA</a></li></ul></li> <li><a href="/wiki/Oncostatin_M_receptor" title="Oncostatin M receptor">OSMR</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor_receptor" title="Leukemia inhibitory factor receptor">LIFR</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTFR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-12_receptor" title="Interleukin-12 receptor">IL12R</a>/<a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB1</a>/<a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB2</a></li> <li><a href="/wiki/Interleukin-23_receptor" title="Interleukin-23 receptor">IL23R</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>other <a href="/wiki/CSF_receptors" class="mw-redirect" title="CSF receptors">CSF receptors</a> <ul><li><a href="/wiki/Erythropoietin_receptor" title="Erythropoietin receptor">EPO</a></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">G-CSF</a></li> <li><a href="/wiki/Thrombopoietin_receptor" title="Thrombopoietin receptor">Thrombopoietin</a></li></ul></li></ul> <ul><li><a href="/wiki/Hormone_receptor" title="Hormone receptor">hormone receptor</a>: <a href="/wiki/Growth_hormone_receptor" title="Growth hormone receptor">GH</a></li> <li><a href="/wiki/Prolactin_receptor" title="Prolactin receptor">prolactin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Type_II_cytokine_receptor" title="Type II cytokine receptor">Type II</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-10_receptor" title="Interleukin-10 receptor">IL10R</a> / <a href="/wiki/Interleukin_10_receptor,_alpha_subunit" title="Interleukin 10 receptor, alpha subunit">IL10RA</a> / <a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">IL10RB</a> / <a href="/wiki/Interleukin-22_receptor" title="Interleukin-22 receptor">IL22R</a> / <a href="/wiki/IL22RA1" title="IL22RA1">IL22RA1</a> / <a href="/wiki/IL22RA2" title="IL22RA2">IL22RA2</a></li> <li><a href="/wiki/Interleukin-20_receptor" title="Interleukin-20 receptor">IL20R</a> / <a href="/wiki/Interleukin_20_receptor,_alpha_subunit" title="Interleukin 20 receptor, alpha subunit">IL20RA</a> / <a href="/wiki/Interleukin_20_receptor,_beta_subunit" title="Interleukin 20 receptor, beta subunit">IL20RB</a></li> <li><a href="/wiki/Interleukin-28_receptor" title="Interleukin-28 receptor">IL28R</a></li></ul></li> <li><a href="/wiki/Interferon_receptor" class="mw-redirect" title="Interferon receptor">Interferon receptors</a> <ul><li><a href="/wiki/Interferon-alpha/beta_receptor" title="Interferon-alpha/beta receptor">-α/β</a> / <a href="/wiki/IFNAR1" title="IFNAR1">IFNAR1</a>/<a href="/wiki/IFNAR2" title="IFNAR2">IFNAR2</a></li> <li><a href="/wiki/Interferon-gamma_receptor" title="Interferon-gamma receptor">-γ</a>/<a href="/wiki/Interferon_gamma_receptor_1" title="Interferon gamma receptor 1">IFNGR1</a> / <a href="/wiki/Interferon_gamma_receptor_2" title="Interferon gamma receptor 2">IFNGR2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Immunoglobulin_superfamily" title="Immunoglobulin superfamily">Ig superfamily</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li class="mw-empty-elt"></li> <li><a href="/wiki/Interleukin-1_receptor" title="Interleukin-1 receptor">IL1</a> <ul><li><a href="/wiki/Interleukin_1_receptor,_type_I" title="Interleukin 1 receptor, type I">IL1R1</a></li> <li><a href="/wiki/Interleukin_1_receptor,_type_II" title="Interleukin 1 receptor, type II">IL1R2</a></li></ul></li> <li><a href="/wiki/Interleukin-18_receptor" title="Interleukin-18 receptor">IL18R</a> / <a href="/wiki/IL18R1" title="IL18R1">IL18R1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/IL_17_family" class="mw-redirect" title="IL 17 family">IL 17 family</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">IL17</a> <ul><li><a href="/wiki/IL17RA" title="IL17RA">IL17RA</a></li> <li><a href="/wiki/IL17RB" title="IL17RB">IL17RB</a></li> <li><a href="/wiki/IL17RC" title="IL17RC">IL17RC</a></li> <li><a href="/wiki/IL17RD" title="IL17RD">IL17RD</a></li> <li><a href="/w/index.php?title=IL17RE&action=edit&redlink=1" class="new" title="IL17RE (page does not exist)">IL17RE</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Enzyme-linked_receptor" title="Enzyme-linked receptor">Enzyme-linked receptor</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">Tyr</a> <ul><li><a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">CSF1R</a></li> <li><a href="/wiki/CD117" class="mw-redirect" title="CD117">KIT</a></li></ul></li> <li><a href="/wiki/Receptor_protein_serine/threonine_kinase" title="Receptor protein serine/threonine kinase">Ser/Thr</a>: <a href="/wiki/TGF_beta_receptors" class="mw-redirect" title="TGF beta receptors">TGF-beta</a> <ul><li><a href="/wiki/TGF_beta_receptor_1" title="TGF beta receptor 1">TGFBR1</a></li> <li><a href="/wiki/TGF_beta_receptor_2" title="TGF beta receptor 2">TGFBR2</a></li> <li><a href="/wiki/TGF-beta_receptor_family" title="TGF-beta receptor family">family</a></li></ul></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Cytokine_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cytokine_receptor_modulators" title="Template talk:Cytokine receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cytokine_receptor_modulators" title="Special:EditPage/Template:Cytokine receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cytokine_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Cytokine_receptor" title="Cytokine receptor">Cytokine receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Chemokine_receptor" title="Chemokine receptor">Chemokine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Chemokine_receptor_modulators" title="Template:Chemokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Colony-stimulating_factor_receptor" class="mw-redirect" title="Colony-stimulating factor receptor">CSF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Erythropoietin_receptor" title="Erythropoietin receptor">Erythropoietin</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=ARA-290&action=edit&redlink=1" class="new" title="ARA-290 (page does not exist)">ARA-290</a></li> <li><a href="/w/index.php?title=Asialo_erythropoietin&action=edit&redlink=1" class="new" title="Asialo erythropoietin (page does not exist)">Asialo erythropoietin</a></li> <li><a href="/w/index.php?title=Carbamylated_erythropoietin&action=edit&redlink=1" class="new" title="Carbamylated erythropoietin (page does not exist)">Carbamylated erythropoietin</a></li> <li><a href="/w/index.php?title=CNTO-530&action=edit&redlink=1" class="new" title="CNTO-530 (page does not exist)">CNTO-530</a></li> <li><a href="/wiki/Darbepoetin_alfa" title="Darbepoetin alfa">Darbepoetin alfa</a></li> <li><a href="/wiki/Epoetin_alfa" title="Epoetin alfa">Epoetin alfa</a></li> <li><a href="/wiki/Epoetin_beta" title="Epoetin beta">Epoetin beta</a></li> <li><a href="/w/index.php?title=Epoetin_delta&action=edit&redlink=1" class="new" title="Epoetin delta (page does not exist)">Epoetin delta</a></li> <li><a href="/w/index.php?title=Epoetin_epsilon&action=edit&redlink=1" class="new" title="Epoetin epsilon (page does not exist)">Epoetin epsilon</a></li> <li><a href="/w/index.php?title=Epoetin_gamma&action=edit&redlink=1" class="new" title="Epoetin gamma (page does not exist)">Epoetin gamma</a></li> <li><a href="/w/index.php?title=Epoetin_kappa&action=edit&redlink=1" class="new" title="Epoetin kappa (page does not exist)">Epoetin kappa</a></li> <li><a href="/w/index.php?title=Epoetin_omega&action=edit&redlink=1" class="new" title="Epoetin omega (page does not exist)">Epoetin omega</a></li> <li><a href="/wiki/Epoetin_theta" title="Epoetin theta">Epoetin theta</a></li> <li><a href="/wiki/Epoetin_zeta" class="mw-redirect" title="Epoetin zeta">Epoetin zeta</a></li> <li><a href="/wiki/Erythropoietin" title="Erythropoietin">Erythropoietin (EPO)</a></li> <li><a href="/w/index.php?title=Erythropoietin-Fc&action=edit&redlink=1" class="new" title="Erythropoietin-Fc (page does not exist)">Erythropoietin-Fc</a></li> <li><a href="/wiki/Methoxy_polyethylene_glycol-epoetin_beta" title="Methoxy polyethylene glycol-epoetin beta">Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)</a></li> <li><a href="/wiki/Peginesatide" title="Peginesatide">Peginesatide</a></li> <li><a href="/w/index.php?title=Pegol_sihematide&action=edit&redlink=1" class="new" title="Pegol sihematide (page does not exist)">Pegol sihematide (EPO-018B)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">G-CSF (CSF3)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Filgrastim" title="Filgrastim">Filgrastim</a></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor" title="Granulocyte colony-stimulating factor">Granulocyte colony-stimulating factor</a></li> <li><a href="/wiki/Lenograstim" title="Lenograstim">Lenograstim</a></li> <li><a href="/w/index.php?title=Leridistim&action=edit&redlink=1" class="new" title="Leridistim (page does not exist)">Leridistim</a></li> <li><a href="/wiki/Lipegfilgrastim" title="Lipegfilgrastim">Lipegfilgrastim</a></li> <li><a href="/w/index.php?title=Nartograstim&action=edit&redlink=1" class="new" title="Nartograstim (page does not exist)">Nartograstim</a></li> <li><a href="/wiki/Pegfilgrastim" title="Pegfilgrastim">Pegfilgrastim</a></li> <li><a href="/w/index.php?title=Pegnartograstim&action=edit&redlink=1" class="new" title="Pegnartograstim (page does not exist)">Pegnartograstim</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">GM-CSF (CSF2)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ecogramostim&action=edit&redlink=1" class="new" title="Ecogramostim (page does not exist)">Ecogramostim</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor">Granulocyte macrophage colony-stimulating factor</a></li> <li><a href="/w/index.php?title=Milodistim&action=edit&redlink=1" class="new" title="Milodistim (page does not exist)">Milodistim</a></li> <li><a href="/wiki/Molgramostim" title="Molgramostim">Molgramostim</a></li> <li><a href="/w/index.php?title=Regramostim&action=edit&redlink=1" class="new" title="Regramostim (page does not exist)">Regramostim</a></li> <li><a href="/wiki/Sargramostim" title="Sargramostim">Sargramostim</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Mavrilimumab" title="Mavrilimumab">Mavrilimumab</a></li> <li><a href="/wiki/Namilumab" title="Namilumab">Namilumab</a></li> <li><a href="/wiki/Otilimab" title="Otilimab">Otilimab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Macrophage colony-stimulating factor receptor">M-CSF (CSF1)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Cilmostim&action=edit&redlink=1" class="new" title="Cilmostim (page does not exist)">Cilmostim</a></li> <li><a href="/wiki/Interleukin-34" class="mw-redirect" title="Interleukin-34">Interleukin-34</a></li> <li><a href="/w/index.php?title=Lanimostim&action=edit&redlink=1" class="new" title="Lanimostim (page does not exist)">Lanimostim</a></li> <li><a href="/wiki/Macrophage_colony-stimulating_factor" title="Macrophage colony-stimulating factor">Macrophage colony-stimulating factor</a></li> <li><a href="/w/index.php?title=Mirimostim&action=edit&redlink=1" class="new" title="Mirimostim (page does not exist)">Mirimostim</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CD117" class="mw-redirect" title="CD117">SCF (c-Kit)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Growth_factor_receptor_modulators" title="Template:Growth factor receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Thrombopoietin_receptor" title="Thrombopoietin receptor">Thrombopoietin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Eltrombopag" title="Eltrombopag">Eltrombopag</a></li> <li><a href="/w/index.php?title=Pegacaristim&action=edit&redlink=1" class="new" title="Pegacaristim (page does not exist)">Pegacaristim</a></li> <li><a href="/wiki/Promegapoietin" title="Promegapoietin">Promegapoietin</a></li> <li><a href="/wiki/Romiplostim" title="Romiplostim">Romiplostim</a></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin (THPO, MGDF)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon_receptor" class="mw-redirect" title="Interferon receptor">Interferon</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon-alpha/beta_receptor" title="Interferon-alpha/beta receptor">IFNAR (α/β, I)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Albinterferon" title="Albinterferon">Albinterferon</a></li> <li><a href="/wiki/Interferon_alpha" class="mw-redirect" title="Interferon alpha">Interferon alpha (interferon alfa, IFN-α)</a></li> <li><a href="/wiki/Interferon_alfa" title="Interferon alfa">Interferon alfa</a> (<a href="/wiki/Interferon_alpha_1" class="mw-redirect" title="Interferon alpha 1">IFNA1</a>, <a href="/wiki/IFNA2" title="IFNA2">IFNA2</a>, <a href="/wiki/IFNA4" title="IFNA4">IFNA4</a>, <a href="/wiki/IFNA5" title="IFNA5">IFNA5</a>, <a href="/wiki/IFNA6" title="IFNA6">IFNA6</a>, <a href="/wiki/IFNA7" title="IFNA7">IFNA7</a>, <a href="/wiki/IFNA8" title="IFNA8">IFNA8</a>, <a href="/wiki/IFNA10" title="IFNA10">IFNA10</a>, <a href="/wiki/IFNA13" title="IFNA13">IFNA13</a>, <a href="/wiki/IFNA14" title="IFNA14">IFNA14</a>, <a href="/wiki/IFNA16" title="IFNA16">IFNA16</a>, <a href="/wiki/IFNA17" title="IFNA17">IFNA17</a>, <a href="/wiki/IFNA21" title="IFNA21">IFNA21</a>)</li> <li><a href="/wiki/Interferon_alfa_2a" class="mw-redirect" title="Interferon alfa 2a">Interferon alfa 2a</a></li> <li><a href="/wiki/Interferon_alfa_2b" class="mw-redirect" title="Interferon alfa 2b">Interferon alfa 2b</a></li> <li><a href="/w/index.php?title=Interferon_alfa_n1&action=edit&redlink=1" class="new" title="Interferon alfa n1 (page does not exist)">Interferon alfa n1</a></li> <li><a href="/wiki/Interferon_alfacon-1" title="Interferon alfacon-1">Interferon alfacon-1</a></li> <li><a href="/wiki/Interferon_alpha-n3" title="Interferon alpha-n3">Interferon alpha-n3</a></li> <li><a href="/wiki/Interferon_beta" class="mw-redirect" title="Interferon beta">Interferon beta (IFN-β)</a> (<a href="/wiki/IFNB1" title="IFNB1">IFNB1</a>, <a href="/w/index.php?title=IFNB3&action=edit&redlink=1" class="new" title="IFNB3 (page does not exist)">IFNB3</a>)</li> <li><a href="/wiki/Interferon_beta_1a" class="mw-redirect" title="Interferon beta 1a">Interferon beta 1a</a></li> <li><a href="/wiki/Interferon_beta_1b" class="mw-redirect" title="Interferon beta 1b">Interferon beta 1b</a></li> <li><a href="/wiki/Interferon_kappa" class="mw-redirect" title="Interferon kappa">Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)</a></li> <li><a href="/wiki/Interferon_omega" class="mw-redirect" title="Interferon omega">Interferon omega (IFN-ω, IFNW1)</a></li> <li><a href="/wiki/Peginterferon_alfa-2a" title="Peginterferon alfa-2a">Peginterferon alfa-2a</a></li> <li><a href="/wiki/Peginterferon_alfa-2b" title="Peginterferon alfa-2b">Peginterferon alfa-2b</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Anifrolumab" title="Anifrolumab">Anifrolumab</a></li> <li><a href="/wiki/Faralimomab" title="Faralimomab">Faralimomab</a></li> <li><a href="/w/index.php?title=MEDI-545&action=edit&redlink=1" class="new" title="MEDI-545 (page does not exist)">MEDI-545</a></li> <li><a href="/wiki/Rontalizumab" title="Rontalizumab">Rontalizumab</a></li> <li><a href="/wiki/Sifalimumab" title="Sifalimumab">Sifalimumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=Bifarcept&action=edit&redlink=1" class="new" title="Bifarcept (page does not exist)">Bifarcept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon-gamma_receptor" title="Interferon-gamma receptor">IFNGR (γ, II)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interferon_gamma" title="Interferon gamma">Interferon gamma (IFN-γ)</a></li> <li><a href="/wiki/Interferon_gamma_1b" class="mw-redirect" title="Interferon gamma 1b">Interferon gamma 1b</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Emapalumab" title="Emapalumab">Emapalumab</a></li> <li><a href="/wiki/Fontolizumab" title="Fontolizumab">Fontolizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon-lambda_receptor" class="mw-redirect" title="Interferon-lambda receptor">IFNLR (λ, III)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See IL-28R (IFNLR) <a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators">here</a> instead.</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Transforming_growth_factor_beta_receptor" class="mw-redirect" title="Transforming growth factor beta receptor">TGFβ</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Template:TGFβ receptor superfamily modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Tumor_necrosis_factor_receptor" class="mw-redirect" title="Tumor necrosis factor receptor">TNF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:TNF_receptor_superfamily_modulators" title="Template:TNF receptor superfamily modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a><br /><small>(<a href="/wiki/Janus_kinase_inhibitor" title="Janus kinase inhibitor">inhibitors</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/JAK1" class="mw-redirect" title="JAK1">JAK1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abrocitinib" title="Abrocitinib">Abrocitinib</a></li> <li><a href="/wiki/Baricitinib" title="Baricitinib">Baricitinib</a></li> <li><a href="/wiki/Deuruxolitinib" title="Deuruxolitinib">Deuruxolitinib</a></li> <li><a href="/wiki/Filgotinib" title="Filgotinib">Filgotinib</a></li> <li><a href="/wiki/Momelotinib" title="Momelotinib">Momelotinib</a></li> <li><a href="/wiki/Oclacitinib" title="Oclacitinib">Oclacitinib</a></li> <li><a href="/wiki/Peficitinib" title="Peficitinib">Peficitinib</a></li> <li><a href="/wiki/Ruxolitinib" title="Ruxolitinib">Ruxolitinib</a></li> <li><a href="/wiki/Tofacitinib" title="Tofacitinib">Tofacitinib (tasocitinib)</a></li> <li><a href="/wiki/Upadacitinib" title="Upadacitinib">Upadacitinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/JAK2" class="mw-redirect" title="JAK2">JAK2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Atiprimod" title="Atiprimod">Atiprimod</a></li> <li><a href="/w/index.php?title=AZD-1480&action=edit&redlink=1" class="new" title="AZD-1480 (page does not exist)">AZD-1480</a></li> <li><a href="/wiki/Baricitinib" title="Baricitinib">Baricitinib</a></li> <li><a href="/wiki/CHZ868" title="CHZ868">CHZ868</a></li> <li><a href="/wiki/Cucurbitacin_I" class="mw-redirect" title="Cucurbitacin I">Cucurbitacin I (elatericin B, JSI-124)</a></li> <li><a href="/wiki/CYT387" class="mw-redirect" title="CYT387">CYT387</a></li> <li><a href="/wiki/Deuruxolitinib" title="Deuruxolitinib">Deuruxolitinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=NSC-7908&action=edit&redlink=1" class="new" title="NSC-7908 (page does not exist)">NSC-7908</a></li> <li><a href="/w/index.php?title=NSC-33994&action=edit&redlink=1" class="new" title="NSC-33994 (page does not exist)">NSC-33994</a></li> <li><a href="/wiki/Pacritinib" title="Pacritinib">Pacritinib</a></li> <li><a href="/wiki/Peficitinib" title="Peficitinib">Peficitinib</a></li> <li><a href="/wiki/Ruxolitinib" title="Ruxolitinib">Ruxolitinib</a></li> <li><a href="/w/index.php?title=SD-1008&action=edit&redlink=1" class="new" title="SD-1008 (page does not exist)">SD-1008</a></li> <li><a href="/wiki/Tofacitinib" title="Tofacitinib">Tofacitinib (tasocitinib)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/JAK3" class="mw-redirect" title="JAK3">JAK3</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Cercosporamide&action=edit&redlink=1" class="new" title="Cercosporamide (page does not exist)">Cercosporamide</a></li> <li><a href="/wiki/Decernotinib" title="Decernotinib">Decernotinib (VX-509)</a></li> <li><a href="/wiki/Peficitinib" title="Peficitinib">Peficitinib</a></li> <li><a href="/wiki/Ritlecitinib" title="Ritlecitinib">Ritlecitinib</a></li> <li><a href="/w/index.php?title=TCS-21311&action=edit&redlink=1" class="new" title="TCS-21311 (page does not exist)">TCS-21311</a></li> <li><a href="/wiki/Tofacitinib" title="Tofacitinib">Tofacitinib (tasocitinib)</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li> <li><a href="/w/index.php?title=ZM-39923&action=edit&redlink=1" class="new" title="ZM-39923 (page does not exist)">ZM-39923</a></li> <li><a href="/w/index.php?title=ZM-449829&action=edit&redlink=1" class="new" title="ZM-449829 (page does not exist)">ZM-449829</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Tyrosine_kinase_2" title="Tyrosine kinase 2">TYK2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Deucravacitinib" title="Deucravacitinib">Deucravacitinib</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Additional cytokines:</i> <a href="/wiki/Cardiotrophin_1" title="Cardiotrophin 1">Cardiotrophin 1 (CT-1)</a></li> <li><a href="/wiki/FMS-like_tyrosine_kinase_3_ligand" title="FMS-like tyrosine kinase 3 ligand">FMS-like tyrosine kinase 3 ligand (FLT3L)</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">Leukemia/leukocyte inhibitory factor (LIF)</a></li> <li><a href="/wiki/Oncostatin_M" title="Oncostatin M">Oncostatin M (OSM)</a></li> <li><a href="/wiki/Thymic_stromal_lymphopoietin" title="Thymic stromal lymphopoietin">Thymic stromal lymphopoietin (TSLP)</a></li></ul> <ul><li><i>Additional cytokine receptor modulators:</i> <a href="/w/index.php?title=Emfilermin&action=edit&redlink=1" class="new" title="Emfilermin (page does not exist)">Emfilermin</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/wiki/Midostaurin" title="Midostaurin">Midostaurin</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Death_receptor_3&oldid=1215963743">https://en.wikipedia.org/w/index.php?title=Death_receptor_3&oldid=1215963743</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_1" title="Category:Genes on human chromosome 1">Genes on human chromosome 1</a></li><li><a href="/wiki/Category:TNF_receptor_family" title="Category:TNF receptor family">TNF receptor family</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:Articles_with_short_description" title="Category:Articles with short description">Articles with short description</a></li><li><a href="/wiki/Category:Short_description_is_different_from_Wikidata" title="Category:Short description is different from Wikidata">Short description is different from Wikidata</a></li><li><a href="/wiki/Category:Wikipedia_articles_incorporating_text_from_the_United_States_National_Library_of_Medicine" title="Category:Wikipedia articles incorporating text from the United States National Library of Medicine">Wikipedia articles incorporating text from the United States National Library of Medicine</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 28 March 2024, at 05:47<span class="anonymous-show"> (UTC)</span>.</li> <li id="footer-info-copyright">Text is available under the <a href="/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License" title="Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License">Creative Commons Attribution-ShareAlike 4.0 License</a>; additional terms may apply. By using this site, you agree to the <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Terms_of_Use" class="extiw" title="foundation:Special:MyLanguage/Policy:Terms of Use">Terms of Use</a> and <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy" class="extiw" title="foundation:Special:MyLanguage/Policy:Privacy policy">Privacy Policy</a>. Wikipedia® is a registered trademark of the <a rel="nofollow" class="external text" href="https://wikimediafoundation.org/">Wikimedia Foundation, Inc.</a>, a non-profit organization.</li> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy">Privacy policy</a></li> <li id="footer-places-about"><a href="/wiki/Wikipedia:About">About Wikipedia</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Wikipedia:General_disclaimer">Disclaimers</a></li> <li id="footer-places-contact"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us">Contact Wikipedia</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">Code of Conduct</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">Developers</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/en.wikipedia.org">Statistics</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Cookie statement</a></li> <li id="footer-places-mobileview"><a href="//en.m.wikipedia.org/w/index.php?title=Death_receptor_3&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">Mobile view</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://wikimediafoundation.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/static/images/footer/wikimedia-button.svg" width="84" height="29" alt="Wikimedia Foundation" loading="lazy"></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/w/resources/assets/poweredby_mediawiki.svg" alt="Powered by MediaWiki" width="88" height="31" loading="lazy"></a></li> </ul> </footer> </div> </div> </div> <div class="vector-settings" id="p-dock-bottom"> <ul></ul> </div><script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.main-f69cdc8f6-hppzn","wgBackendResponseTime":157,"wgPageParseReport":{"limitreport":{"cputime":"0.612","walltime":"0.900","ppvisitednodes":{"value":1894,"limit":1000000},"postexpandincludesize":{"value":204985,"limit":2097152},"templateargumentsize":{"value":429,"limit":2097152},"expansiondepth":{"value":8,"limit":100},"expensivefunctioncount":{"value":25,"limit":500},"unstrip-depth":{"value":1,"limit":20},"unstrip-size":{"value":94428,"limit":5000000},"entityaccesscount":{"value":25,"limit":400},"timingprofile":["100.00% 766.877 1 -total"," 52.05% 399.162 1 Template:Infobox_gene"," 15.30% 117.345 10 Template:Navbox"," 14.35% 110.012 1 Template:Short_description"," 13.56% 104.016 22 Template:Cite_journal"," 11.85% 90.845 1 Template:Tumor_necrosis_factor_receptor_superfamily"," 8.14% 62.426 3 Template:Main_other"," 7.89% 60.524 1 Template:SDcat"," 7.24% 55.491 1 Template:Reflist"," 4.81% 36.883 2 Template:Pagetype"]},"scribunto":{"limitreport-timeusage":{"value":"0.431","limit":"10.000"},"limitreport-memusage":{"value":8261074,"limit":52428800}},"cachereport":{"origin":"mw-web.eqiad.main-5dc468848-8bmpv","timestamp":"20241122152224","ttl":2592000,"transientcontent":false}}});});</script> <script type="application/ld+json">{"@context":"https:\/\/schema.org","@type":"Article","name":"Death receptor 3","url":"https:\/\/en.wikipedia.org\/wiki\/Death_receptor_3","sameAs":"http:\/\/www.wikidata.org\/entity\/Q18033239","mainEntity":"http:\/\/www.wikidata.org\/entity\/Q18033239","author":{"@type":"Organization","name":"Contributors to Wikimedia projects"},"publisher":{"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":{"@type":"ImageObject","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-hor-googpub.png"}},"datePublished":"2007-12-18T22:32:10Z","dateModified":"2024-03-28T05:47:47Z","image":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/d\/d6\/Ideogram_human_chromosome_1.svg","headline":"protein-coding gene in the species Homo sapiens"}</script> </body> </html>