CINXE.COM

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illusoire », nous répondons: </div>  <div class="tp-caption tp-resizeme" id="slide-5-layer-2" data-x="['left','left','left','left']" data-hoffset="['100','120','100','61']" data-y="['top','top','top','top']" data-voffset="['200','200','190','160']" data-width="['550','550','345','266']" data-height="none" data-whitespace="nowrap" data-type="text" data-responsive_offset="on" data-frames='[{"delay":10,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[0,0,0,0]" data-paddingright="[0,0,0,0]" data-paddingbottom="[0,0,0,0]" data-paddingleft="[0,0,0,0]" style="z-index: 6; min-width: 550px; max-width: 550px; white-space: nowrap; font-size: 35px; line-height: 40px; font-weight: 700; color: #ffffff; letter-spacing: 0px;font-family:Source Sans Pro;white-space:normal;">Défi accepté! </div>  <div class="tp-caption tp-resizeme" id="slide-5-layer-3" data-x="['left','left','left','left']" data-hoffset="['100','120','100','55']" data-y="['top','top','top','top']" data-voffset="['260','260','250','220']" data-fontsize="['22','22','18','18']" data-width="['550','550','345','266']" data-height="none" data-whitespace="nowrap" data-type="text" data-responsive_offset="on" data-frames='[{"delay":10,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[0,0,0,0]" data-paddingright="[0,0,0,0]" data-paddingbottom="[0,0,0,0]" data-paddingleft="[0,0,0,0]" style="z-index: 7; min-width: 550px; max-width: 550px; white-space: nowrap; font-size: 22px; line-height: 33px; font-weight: 300; color: #ffffff; letter-spacing: 0px;font-family:Source Sans Pro;white-space:normal;">Nous mettons au point une nouvelle classe de médicaments innovants appelés <em>acides ribonucléiquesn interférents</em> (ARNi) qui, nous en avons la conviction, ont le potentiel de changer la vie desn personnes affligées de certaines maladies rares. </div>  <div class="tp-caption rev-btn " id="slide-5-layer-4" data-x="['left','left','left','left']" data-hoffset="['100','120','100','61']" data-y="['top','top','top','top']" data-voffset="['435','436','477','490']" data-width="none" data-height="none" data-whitespace="nowrap" data-type="button" data-actions='[{"event":"click","action":"simplelink","target":"_self","url":"\/fr\/apropos-alnylam","delay":""}]' data-responsive_offset="on" data-responsive="off" data-frames='[{"delay":10,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"},{"frame":"hover","speed":"0","ease":"Linear.easeNone","to":"o:1;rX:0;rY:0;rZ:0;z:0;","style":"c:rgb(255,255,255);bs:solid;bw:0 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data-frames='[{"delay":0,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[0,0,0,0]" data-paddingright="[0,0,0,0]" data-paddingbottom="[0,0,0,0]" data-paddingleft="[0,0,0,0]" style="z-index: 5; min-width: 550px; max-width: 550px; white-space: nowrap; font-size: 28px; line-height: 33px; font-weight: 400; color: #ffffff; letter-spacing: 0px;font-family:Source Sans Pro;white-space:normal;">Nous nous concentrons sur des maladies pour lesquelles il n’existe que peu ou pas d’options thérapeutiques. </div>  <div class="tp-caption tp-resizeme" id="slide-6-layer-2" data-x="['left','left','left','left']" data-hoffset="['100','120','100','61']" data-y="['top','top','top','top']" data-voffset="['220','219','155','160']" data-fontsize="['33','33','30','25']" data-lineheight="['40','40','35','30']" data-width="['550','550','345','266']" data-height="none" data-whitespace="nowrap" data-type="text" data-responsive_offset="on" data-frames='[{"delay":0,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[0,0,0,0]" data-paddingright="[0,0,0,0]" data-paddingbottom="[0,0,0,0]" data-paddingleft="[0,0,0,0]" style="z-index: 6; min-width: 550px; max-width: 550px; white-space: nowrap; font-size: 33px; line-height: 40px; font-weight: 700; color: #ffffff; letter-spacing: 0px;font-family:Source Sans Pro;white-space:normal;">Notre riche gamme de produits en développement </div>  <div class="tp-caption tp-resizeme" id="slide-6-layer-3" data-x="['left','left','left','left']" data-hoffset="['100','120','97','56']" data-y="['top','top','top','top']" data-voffset="['320','320','280','270']" data-fontsize="['22','22','18','18']" data-lineheight="['33','33','33','30']" data-width="['550','550','345','266']" data-height="none" data-whitespace="nowrap" data-type="text" data-responsive_offset="on" data-frames='[{"delay":0,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[0,0,0,0]" data-paddingright="[0,0,0,0]" data-paddingbottom="[0,0,0,0]" data-paddingleft="[0,0,0,0]" style="z-index: 7; min-width: 550px; max-width: 550px; white-space: nowrap; font-size: 22px; line-height: 33px; font-weight: 300; color: #ffffff; letter-spacing: 0px;font-family:Source Sans Pro;white-space:normal;">Nous mettons au point des ARNi thérapeutiques expérimentaux pour traiter des maladies génétiques, cardiométaboliques, infectieuses et oculaires ou touchant le système nerveux central (SNC). </div>  <div class="tp-caption rev-btn " id="slide-6-layer-4" data-x="['left','left','left','left']" data-hoffset="['104','120','101','52']" data-y="['top','top','top','top']" data-voffset="['490','490','480','500']" data-fontsize="['18','18','18','16']" data-lineheight="['30','30','30','25']" data-width="['none','none','none','272']" data-height="none" data-whitespace="nowrap" data-type="button" data-actions='[{"event":"click","action":"simplelink","target":"_self","url":"\/fr\/produits-d\u00e9veloppement","delay":""}]' data-responsive_offset="on" data-responsive="off" data-frames='[{"delay":0,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"},{"frame":"hover","speed":"0","ease":"Linear.easeNone","to":"o:1;rX:0;rY:0;rZ:0;z:0;","style":"c:rgb(255,255,255);bs:solid;bw:0 0 0 0;"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[12,12,12,12]" 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field--items"> <div class="field--item"> <div class="paragraph paragraph--type--callout-box paragraph--view-mode--default"> <div class="field field--name-field-callout-heading field--type-text field--label-hidden field--item">DERNIÈRES NOUVELLES</div> <div class="field field--name-field-callout-link field--type-text-long field--label-hidden field--item"><p><a href="/sites/default/files/news-articles/Oxlumo Press Release v2_FR.pdf" target="_blank">Alnylam lance troisième traitement à base d'ARNi approuvé au Canada</a></p> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--page-title paragraph--view-mode--default"> <div class="field field--name-field-page-ti field--type-text field--label-hidden field--item">NOUS ASPIRONS À CHANGER LA FAÇON DONT LA MÉDECINE TRAITE LES MALADIES</div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--centered-text paragraph--view-mode--default"> <div class="field field--name-field-centered-text field--type-text-long field--label-hidden field--item"><p>Alnylam est chef de file dans l’adaptation des ARN interférents (ARNi) en une nouvelle classe de médicaments d’avant-garde destinés aux patients dont les options thérapeutiques sont limitées ou inadéquates. Issus de travaux récompensés par un prix Nobel, les ARNi thérapeutiques constituent de puissants agents cliniquement validés pour le traitement d’un grand éventail de maladies graves et invalidantes.</p> <p>Depuis sa fondation en 2002, Alnylam concrétise la vision audacieuse de transformer le potentiel scientifique en réalité thérapeutique, avec une solide plate-forme de découverte d’ARNi et un grand portefeuille de médicaments expérimentaux comprenant trois médicaments homologué au Canada, cinq programmes aux derniers stades de développement clinique et de nombreux autres aux premiers stades de développement clinique.</p> </div> </div> </div> </div> <div class="field field--name-field-big-numbers field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>1<span>k</span></div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">employés</div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">19</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">pays</div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">11</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">programmes en développement clinique</div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">4</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">produits approuvés</div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>35</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">études cliniques menées à ce jour</div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>8</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">ans pour l’exposition la plus longue</div> </div> </div> </div> <div class="field field--name-field-big-numbers-slider field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--slideshow paragraph--view-mode--default"> <div class="slick blazy slick--field slick--field-slides slick--field-slides--default slick--skin--default slick--optionset--custom" data-blazy="" id="slick-paragraph-slideshow-slides-default-22-1"> <div id="slick-paragraph-slideshow-slides-default-22-1-slider" data-slick="{"autoplay":true,"pauseOnHover":false,"pauseOnFocus":false,"autoplaySpeed":9000,"arrows":false,"dots":true,"fade":true,"speed":1000,"waitForAnimate":false,"count":6}" class="slick__slider"> <div class="slick__slide slide slide--0"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>1<span>k</span></div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">employés</div> </div> </div> <div class="slick__slide slide slide--1"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">19</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">pays</div> </div> </div> <div class="slick__slide slide slide--2"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">11</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">programmes en développement clinique</div> </div> </div> <div class="slick__slide slide slide--3"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">4</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">produits approuvés</div> </div> </div> <div class="slick__slide slide slide--4"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>35</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">études cliniques menées à ce jour</div> </div> </div> <div class="slick__slide slide slide--5"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>8</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">ans pour l’exposition la plus longue</div> </div> </div> </div> <nav role="navigation" class="slick__arrow"> <button type="button" data-role="none" class="slick-prev" aria-label="Previous" tabindex="0">Previous</button> <button type="button" data-role="none" class="slick-next" aria-label="Next" tabindex="0">Next</button> </nav> </div> </div> </div> </div> <div class="field field--name-field-body-lower field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--footnote paragraph--view-mode--default"> <div class="field field--name-field-footnote field--type-text field--label-hidden field--items"> <div class="field--item">Mis à jour en Avril 2022</div> </div> </div> </div> </div> <div class="field field--name-field-body-full-width field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--rnai paragraph--view-mode--default"> <div class="field field--name-field-rnai-text field--type-text-long field--label-hidden field--items"> <div class="field--item"><h3>ARNi : UNE RÉVOLUTION EN BIOLOGIE FONDÉE SUR DES RECHERCHES RÉCOMPENSÉES PAR UN PRIX NOBEL</h3> <p>La découverte des ARN interférents (ARNi) constitue une percée dans la compréhension de la façon dont les gènes sont régulés dans les cellules. Elle a aussi donné lieu à une approche totalement nouvelle appliquée à la découverte et au développement de médicaments. Le prix Nobel 2006 de physiologie ou de médecine, décerné à Craig Mello et à Andrew Fire, a reconnu l’importance des ARNi en tant que découverte scientifique majeure.</p> <p><a href="/fr/notre-science">En savoir plus ›</a></p> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--focus paragraph--view-mode--default"> <div class="field field--name-field-focus field--type-text-long field--label-hidden field--items"> <div class="field--item"><h2>NOTRE PRIORITÉ</h2> <p>Nos recherches sur les ARNi thérapeutiques visent à combler d’importants besoins médicaux dans quatre domaines thérapeutiques stratégiques : médicaments génétiques, maladies cardiométaboliques, maladies infectieuses et maladies oculaires ou touchant le système nerveux central (SNC).</p> <p><a href="/fr/produits-développement">Voir nos produits en développement ›</a></p> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--join-our-team paragraph--view-mode--default"> <div class="field field--name-field-join-our-team field--type-text-long field--label-hidden field--items"> <div class="field--item"><h2 class="show-mobile">JOIGNEZ-VOUS <span style="white-space:nowrap;">À NOUS</span></h2> <div class="join-img wpb_animate_when_almost_visible wpb_left-to-right left-to-right wpb_column vc_column_container vc_col-sm-5 vc_col-lg-7 vc_col-md-6 vc_col-xs-12"><img alt="Canda FR" data-entity-type="file" data-entity-uuid="6ee6510a-a0d2-41ce-8164-0e3ae895696e" height="auto" src="/sites/default/files/inline-images/cpl-canada-frenchbadge.png" width="2088" loading="lazy" /></div> <div class="join-text"> <h2 class="hide-mobile">JOIGNEZ-VOUS <span style="white-space:nowrap;">À NOUS</span></h2> <p>Notre entreprise est en pleine croissance et nous recrutons partout en Amérique du Nord, en Europe, en Asie et en Amérique latine afin de pourvoir des postes dans divers domaines. Nous sommes à la recherche de gens intelligents, passionnés, déterminés à changer le monde et prêts à répondre « défi accepté » pour nous aider à accomplir notre mission.</p> <p><a data-target="#NachrichtenModal" data-toggle="modal" href="http://jobs.alnylam.com/" target="_blank">Consulter les occasions de carrière ›</a></p> </div> </div> </div> </div> </div> </div> </div> </article> <section id="block-externalmodal" class="block block-block-content block-block-contentd9368e1b-3d21-4012-b93b-f06d3a4e1bfa clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div aria-labelledby="myModalLabel1" class="modal fade in" id="leave-modal" role="dialog" tabindex="-1"> <div class="modal-dialog modal-lg" role="document"> <div class="modal-content"> <div class="modal-header"><button aria-label="Close" class="close" data-dismiss="modal" type="button"><span aria-hidden="true">X</span></button></div> <div class="modal-body"> <h3>REDIRECTION VERS 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