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class="region region-system-messages"> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-showcase-lite-page-title" class="clearfix block block-core block-page-title-block"> <div class="content"> <h1 class="title page-title"><span class="field field--name-title field--type-string field--label-hidden">Histology and Light Microscopy Core</span> </h1> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="clearfix main-content region--dark-typography region--white-background region--no-separator"> <div class="landing-page-container" > <div class="clearfix main-content__container"> <div class="row"> <section> <div class="clearfix main-content__section" > <div class="region region-content"> <div id="block-showcase-lite-content" class="clearfix block block-system block-system-main-block"> <div class="content"> <article data-history-node-id="3269" class="node node--type-core-mini-sites node--promoted node--view-mode-full clearfix"> <div class="node__container"> <div class="node__main-content clearfix"> <header class="node__header"> </header> <div id="mini-core-tabs" class="row"> <div id="subtabs" class="subtabs"> <ul class="sudonav"> <li class="tab"><a href="#overview"><span>Overview</span></a></li> <li class="tab"><a href="#services"><span>Services</span></a></li> <li class="tab"><a href="#fees-and-scheduling"><span>Fees and Scheduling</span></a></li> <li class="tab"><a href="#publications"><span>Publications</span></a></li> <li class="tab"><a href="#equipment"><span>Equipment</span></a></li> <li class="tab"><a href="#faqs"><span>FAQs</span></a></li> <li class="tab"><a href="#contact"><span>Contact</span></a></li> </ul> <div class="content-wrap"> <section id="overview"> <div id="intro"> <div class="container"> <p class="large">The Histology and Light Microscopy Core provides technical assistance, training, consultation, and collaboration for all aspects of experimental design, sample preparation, image processing, and data analysis. Our core is equipped with state-of-the-art technologies and expertise in histology, high-resolution histological imaging, confocal microscopy, light sheet microscopy, spinning disk microscopy, and optical projection tomography.</p> <p>We strive to provide you with the knowledge and equipment you need to successfully perform your experiment. Our core also offers self service access for trained users.</p> <p>Biology is a beautiful thing, and we want to work with you to make it that way!</p> </div> </div> <div id="manager"> <div class="container"> <h2>Contact</h2> <p><a href="#" rel="noopener" target="_blank" data-mail-to=" uvfgbybtl-nqzva/ng/tynqfgbar/qbg/hpfs/qbg/rqh" data-replace-inner="@email">Email@email</a> for any information relating to POs, quotes, and administrative inquiries.<br> <a href="#" data-mail-to="uvfgbybtl-grpu/ng/tynqfgbar/qbg/hpfs/qbg/rqh" data-replace-inner="@email">Email @email </a>for any technical questions regarding projects.</p> </div> </div> <div class="core-members"> <div class="container"> <h2>Core Members</h2> <div class="views-element-container"><div class="view view-user-admin-people view-id-user_admin_people view-display-id-histology_members js-view-dom-id-56687b305313cde16ae75b5aef9f3115b76d1dd7728635ebcd59fb9569b1d855"> <div class="view-header"> <style> .view-display-id-histology_members .views-row { margin-bottom: 32px; } </style> </div> <div class="view-content"> <div class="views-view-grid horizontal cols-2 clearfix"> <div class="views-row clearfix row-1"> <div class="views-col col-1" style="width: 50%;"><article class="user user--compnomail"> <div class="user__compact"> <p><b>Rebecca Blandino</b><br>Senior Research Technologist<br></p> </div> </article> </div> <div class="views-col col-2" style="width: 50%;"><article class="user user--compnomail"> <div class="user__compact"> <p><b>Rose Guerrero</b><br>Senior Research Technologist<br></p> </div> </article> </div> </div> <div class="views-row clearfix row-2"> <div class="views-col col-1" style="width: 50%;"><article class="user user--compnomail"> <div class="user__compact"> <p><b>Alex Liu</b><br>Research Technologist I<br></p> </div> </article> </div> <div class="views-col col-2" style="width: 50%;"><article class="user user--compnomail"> <div class="user__compact"> <p><b>Jane Srivastava</b><br>Core Director, Flow Cytometry, Light Microscopy and Histology<br></p> </div> </article> </div> </div> </div> </div> </div> </div> </div> </div> <div class="corebk1">   </div> <div id="related-news"> <div class="container"> <h2>Related News</h2> <div class="owl-carousel" id="news-carousel"> <a href="/news/could-targeting-alzheimers-associated-protein-prevent-autism" title="Read more" target="_self"><div class="item"><img alt="Lennart Mucke and Chao Tai walking down the street and talking to each other" class="owl-lazy" data-src="/sites/default/files/styles/news_card/public/news-events/mucke-chao-tai.jpg?itok=VnCwP2oq " /><div class="blowpic">Could Targeting an Alzheimer’s-Associated Protein Prevent Autism?<br><div class="summy">New study shows reducing levels of the protein tau prevents core autism symptoms in animal models</div><div class="authored"><time datetime="2020-03-02T00:00:00-08:00" class="datetime">March 2, 2020</time> </div></div></div></a><a href="/news/machine-meet-stem-cells" title="Read more" target="_self"><div class="item"><img alt="Todd McDevitt and Ashley Libby standing behind David Joy who is working on a computer in the lab" class="owl-lazy" data-src="/sites/default/files/styles/news_card/public/news-events/AshleyBruceDavid.jpg?itok=ycr4Rp_m " /><div class="blowpic">Machine, Meet Stem Cells<br><div class="summy">Gladstone researchers used a machine-learning approach to discover new ways of controlling the spatial organization of induced pluripotent stem cells.</div><div class="authored"><time datetime="2019-11-20T00:00:00-08:00" class="datetime">November 20, 2019</time> </div></div></div></a> </div> </div> </div> </section> <section id="services"> <div id="capab-intro"> <div class="container"> <h2 class="tabtop">Services Provided</h2> <p>In addition to technical assistance and consultation on our services, we also provide training so that you can utilize the equipment on your own time.</p> <h3>Histology</h3> <ul> <li>Tissue processing (paraffin/FFPE and frozen/cryo)</li> <li>Tissue embedding</li> <li>Tissue sectioning</li> <li>Tissue staining and whole slide scanning <ul style="margin-bottom:-10px;list-style-image:none"> <li style='list-style-type: "–";'>H&E</li> <li style='list-style-type: "–";'>IHC, IFA</li> <li style='list-style-type: "–";'>ISH, TUNEL</li> <li style='list-style-type: "–";'>Special staining (PAS, ORO, Congo Red, Masson's Trichrome)</li> <li style='list-style-type: "–";'>Spatial Biology: 10x Visium, RNAscope</li> </ul> </li> </ul> <h3>Advanced Microscopy</h3> <p style="padding-top:10px;padding-bottom:0">On live and fixed samples</p> <ul> <li>Confocal/super-resolution</li> <li>Spinning disk</li> <li>Light-sheet, tissue clearing, volumetric imaging</li> <li>Automated whole slide scanning</li> <li>Widefield microscopy</li> </ul> <h3>Computer-Based Data Analysis</h3> <ul> <li>Mammoth: Imaris Workstation (Room 327) <ul style="list-style-image:none;margin-bottom:10px"> <li style='list-style-type: "–";'>Imaris Software</li> <li style='list-style-type: "–";'>Stitchy Software “Stitching Software”</li> <li style='list-style-type: "–";'>Imagescope, ImageJ/FIJI, OlyVia…</li> </ul> </li> <li>Gladstone Institute of Cardiovascular Disease Workstation</li> <li>Gladstone Institute of Neurological Disease Workstation</li> <li>Stereology: StereoInvestor</li> </ul> <h3>Training, consulting, and collaborations</h3> <h3>Self-services: Equipment Usage (after training)</h3> <p>If you have additional questions, check out our <a href="#faqs">FAQs</a>.</p> </div> </div> <div class="corebk2">   </div> </section> <section id="fees-and-scheduling"> <div class="container"> <h2 class="tabtop">Fees and Scheduling</h2> <h3>Scheduling</h3> <p>The Histology and Light Microscopy Core recharges researchers at an hourly rate for training and support with microscopes and sample preparation. Consult with our staff before preparing samples to ensure your reagents match the available equipment.</p> <p>You are required to complete an initial training session before using any equipment in the core.</p> <p><strong>If you are part of UC San Francisco:</strong></p> <ul> <li><a href="https://gladstone.corefacilities.org/account/34/signup?sc_id=2929">Create an account on iLab</a></li> <li>Add your lab or PI’s PO number to your profile or account</li> <li>Request services on iLab</li> </ul> <p><strong>If you are part of a nonprofit institution or a private company:</strong></p> <ul> <li>Contact the core at <a href="mailto:histology@gladston.ucsf.edu">histology@gladstone.ucsf.edu</a></li> <li>Complete the lab service agreement and email it to the core</li> <li><a href="https://ucsf.ilab.agilent.com/account/22/signup">Create an account on iLab</a></li> <li>Request services on iLab</li> </ul> <p><strong>Microscope Reservation</strong></p> <ul> <li><a href="https://gladstone.corefacilities.org/account/34/signup?sc_id=2929" target="_blank">Make a reservation in iLab</a></li> </ul> <p><strong>To start your session with an already existing reservation:</strong></p> <ul> <li>To access your existing reservation, visit the equipment kiosk. Use your iLab credentials to log in.</li> <li>Once logged in, you will see a list of your pre-scheduled reservations under “My kiosk sessions.”</li> <li>Once you find your session, click the green “start” button. You will see the details of your reservation as well as a timer.</li> <li>You may log out while your session is in process. To log out, click the upper right-hand side menu and select "Log out." On the logout screen, you will see your list of Active sessions.</li> </ul> <p><strong>To start your session as a walk-in:</strong></p> <ul> <li><a href="https://gladstone.corefacilities.org/service_centers/2965/equipment_kiosk/authenticate">Log in to the core kiosk</a> using your iLab credentials.</li> <li>Select the instrument you would like to use from the menu.</li> <li>Once a calendar of availability appears, select “create session." Choose your desired duration, and click “create session” again.</li> <li>A new window will appear with the details for that reservation. You may be required to enter in your payment information and the equipment use type.</li> <li>Once you fill out all the required information, click the start button to begin your session. After you click start, you will see a timer in the upper right-hand corner.</li> <li>To navigate back to your list of sessions, click in the drop-down menu where you see your name and select “my reservations.”</li> <li>To log out, click the upper right-hand side menu and select “Log out.” You may log out while your session is in process. On the logout screen, you will see your list of active sessions.</li> </ul> <p><strong>To end your session:</strong></p> <ul> <li><a href="https://gladstone.corefacilities.org/service_centers/2965/equipment_kiosk/authenticate">Login to the core kiosk</a> using your iLab credentials.</li> <li>Find your current reservation in the list under “My kiosk sessions” and click the blue finish button.</li> <li>Confirm your action and click “finish session.” Your time on the instrument has been logged.</li> </ul> <p>For questions, visit our <a href="#faqs">FAQ</a> page.</p> </div> <div class="corebk3">   </div> </section> <section id="publications"> <div class="container"> <h2 class="tabtop">Recent Publications</h2> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31873194/">Microglial microRNAs mediate sex-specific responses to tau pathology.</a> A. Hsu, Q. Duan, S. McMahon, Y. Huang, S. A. Wood, N. S. Gray, B. Wang, B. G. Bruneau and S. M. Haldar. (2020). Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. J Clin Invest, doi:10.1172/JCI133753 • L. Kodama, E. Guzman, J. I. Etchegaray, Y. Li, F. A. Sayed, L. Zhou, Y. Zhou, L. Zhan, D. Le, J. C. Udeochu, C. D. Clelland, Z. Cheng, G. Yu, Q. Li, K. S. Kosik and L. Gan (2020). <em>Nat Neurosci.</em> 23(2), 167–171. doi:10.1038/s41593-019-0560-7</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32126198/">Tau Reduction Prevents Key Features of Autism in Mouse Models.</a> C. Tai, C. W. Chang, G. Q. Yu, I. Lopez, X. Yu, X. Wang, W. Guo and L. Mucke (2020). <em>Neuron.</em> doi:10.1016/j.neuron.2020.01.038</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32111148/">Single-Cell Determination of Cardiac Microtissue Structure and Function Using Light Sheet Microscopy.</a> D. Turaga, O. B. Matthys, T. A. Hookway, D. A. Joy, M. Calvert and T. C. McDevitt (2020). <em>Tissue Eng Part C Methods. </em>doi:10.1089/ten.TEC.2020.0020</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31759947/">Self-Organized Pluripotent Stem Cell Patterning by Automated Design.</a> D. Briers, A.R.G. Libby, I. Haghighi, D.A. Joy, B.R. Conklin, C. Belta, T.C. McDevitt (2019). <em>Cell.</em> doi:10.2139/ssrn.3318933</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33054973/">A Mac2-positive progenitor-like microglial population survives independent of CSF1R signaling in adult mouse brain.</a> L.Zhan, P.D. Sohn, Y. Zhou, Y. Li, L. Gan (2019). <em>bioRxiv.</em> doi:10.1101/722090.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31271750/">Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.</a> N.R. Stone, C.A. Gifford, R. Thomas, K.J.B. Pratt, K. Samse-Knapp, T.M.A. Mohamed, E.M. Radzinsky, A. Schricker, L. Ye, P. Yu, J.G. van Bemmel, K.N. Ivey, K.S.Pollard, D. Srivastava (2019). <em>Cell Stem Cell.</em> 25(1), 87–102.e9</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31341279/">Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects.</a> T.Y. de Soysa, S.S. Ranade, S. Okawa, S. Ravichandran, Y. Huang, H.T. Salunga, A. Schricker, A. del Sol, C.A. Gifford, D. Srivastava (2019). <em>Nature.</em> 572, 120–124.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30936836/">Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System.</a> E. Samal, M. Evangelista, G, Galang, D. Srivastava, Y. Zhao, V. Vedantham (2019). <em>Frontiers in Physiology.</em> doi: 10.3389/fphys.2019.00235</p> <h2>Gladstone-led Publications</h2> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29618808/">Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.</a> M. A. Petersen, J. K. Ryu and K. Akassoglou (2018). <em>Nat Rev Neurosci.</em> 19(5), 283–301. doi:10.1038/nrn.2018.13 </p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31873194/">Microglial microRNAs mediate sex-specific responses to tau pathology.</a> L. Kodama, E. Guzman, J. I. Etchegaray, Y. Li, F. A. Sayed, L. Zhou, Y. Zhou, L. Zhan, D. Le, J. C. Udeochu, C. D. Clelland, Z. Cheng, G. Yu, Q. Li, K. S. Kosik and L. Gan (2020). <em>Nat Neurosci.</em> 23(2), 167–171. doi:10.1038/s41593-019-0560-7</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31171460/">Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?</a> L. Kodama and L. Gan (2019). <em>Trends Mol Med.</em> 25(9), 741–749. doi:10.1016/j.molmed.2019.05.001 </p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30232263/">Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.</a> F. A. Sayed, M. Telpoukhovskaia, L. Kodama, Y. Li, Y. Zhou, D. Le, A. Hauduc, C. Ludwig, F. Gao, C. Clelland, L. Zhan, Y. A. Cooper, D. Davalos, K. Akassoglou, G. Coppola and L. Gan (2018). <em>Proc Natl Acad Sci U S A.</em> 115(40), 10172–10177. doi:10.1073/pnas.1811411115 </p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30735499/">Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.</a> L. Zhan, G. Krabbe, F. Du, I. Jones, M. C. Reichert, M. Telpoukhovskaia, L. Kodama, C. Wang, S. H. Cho, F. Sayed, Y. Li, D. Le, Y. Zhou, Y. Shen, B. West and L. Gan (2019). <em>PLoS Biol.</em> 17(2), e3000134. doi:10.1371/journal.pbio.3000134</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/24319660/">Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State.</a> J.D. Fu, N.R. Stone, L. Liu, C.I Spencer, L. Qian, Y. Hayashi, P. Delgado-Olguin, S. Ding, B.G. Bruneau, D. Srivastava (2013). <em>Stem Cell Reports.</em> 1, 235–247 </p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31271750/">Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.</a> N. R. Stone, C. A. Gifford, R. Thomas, K. J. B. Pratt, K. Samse-Knapp, T. M. A. Mohamed, E. M. Radzinsky, A. Schricker, L. Ye, P. Yu, J. G. van Bemmel, K. N. Ivey, K. S. Pollard and D. Srivastava (2019). <em>Cell Stem Cell.</em> 25(1), 87–102 e109. doi:10.1016/j.stem.2019.06.012 </p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27834668/">Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming.</a> T. M. Mohamed, N. R. Stone, E. C. Berry, E. Radzinsky, Y. Huang, K. Pratt, Y. S. Ang, P. Yu, H. Wang, S. Tang, S. Magnitsky, S. Ding, K. N. Ivey and D. Srivastava (2017). <em>Circulation.</em> 135(10), 978–995. doi:10.1161/CIRCULATIONAHA.116.024692 </p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32005867/">Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling.</a> L. Pous, S. S. Deshpande, S. Nath, S. Mezey, S. C. Malik, S. Schildge, C. Bohrer, K. Topp, D. Pfeifer, F. Fernandez-Klett, S. Doostkam, D. K. Galanakis, V. Taylor, K. Akassoglou and C. Schachtrup (2020). <em>Nat Commun.</em> 11(1), 630. doi:10.1038/s41467-020-14466-y </p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31472115/">Imaging the dynamic interactions between immune cells and the neurovascular interface in the spinal cord.</a> N. Borjini, E. Paouri, R. Tognatta, K. Akassoglou and D. Davalos (2019). <em>Exp Neurol.</em> 322(113046). doi:10.1016/j.expneurol.2019.113046 </p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31601561/">Chromatin and epigenetics in development: a Special Issue.</a> B. G. Bruneau, H. Koseki, S. Strome and M. E. Torres-Padilla (2019). <em>Development.</em> 146(19), doi:10.1242/dev.185025</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31358948/">Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards.</a> A. L. Lind, Y. Y. Y. Lai, Y. Mostovoy, A. K. Holloway, A. Iannucci, A. C. Y. Mak, M. Fondi, V. Orlandini, W. L. Eckalbar, M. Milan, M. Rovatsos, I. G. Kichigin, A. I. Makunin, M. Johnson Pokorna, M. Altmanova, V. A. Trifonov, E. Schijlen, L. Kratochvil, R. Fani, P. Velensky, I. Rehak, T. Patarnello, T. S. Jessop, J. W. Hicks, O. A. Ryder, J. R. Mendelson, 3rd, C. Ciofi, P. Y. Kwok, K. S. Pollard and B. G. Bruneau (2019). <em>Nat Ecol Evol.</em> 3(8), 1241–1252. doi:10.1038/s41559-019-0945-8</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31599722/">CTCF confers local nucleosome resiliency after DNA replication and during mitosis.</a> N. Owens, T. Papadopoulou, N. Festuccia, A. Tachtsidi, I. Gonzalez, A. Dubois, S. Vandormael-Pournin, E. P. Nora, B. G. Bruneau, M. Cohen-Tannoudji and P. Navarro (2019). <em>Elife.</em> 8, doi:10.7554/eLife.47898</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31522988/">RNA Interactions Are Essential for CTCF-Mediated Genome Organization.</a> R. Saldana-Meyer, J. Rodriguez-Hernaez, T. Escobar, M. Nishana, K. Jacome-Lopez, E. P. Nora, B. G. Bruneau, A. Tsirigos, M. Furlan-Magaril, J. Skok and D. Reinberg (2019). <em>Mol Cell.</em> 76(3), 412–422 e415. doi:10.1016/j.molcel.2019.08.015</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30660610/">A De Novo Shape Motif Discovery Algorithm Reveals Preferences of Transcription Factors for DNA Shape Beyond Sequence Motifs.</a> M. A. H. Samee, B. G. Bruneau and K. S. Pollard (2019). <em>Cell Syst.</em> 8(1), 27–42 e26. doi:10.1016/j.cels.2018.12.001</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29103804/">Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage</a>. M. A. Petersen, J. K. Ryu, K. J. Chang, A. Etxeberria, S. Bardehle, A. S. Mendiola, W. Kamau-Devers, S. P. J. Fancy, A. Thor, E. A. Bushong, B. Baeza-Raja, C. A. Syme, M. D. Wu, P. E. Rios Coronado, A. Meyer-Franke, S. Yahn, L. Pous, J. K. Lee, C. Schachtrup, H. Lassmann, E. J. Huang, M. H. Han, M. Absinta, D. S. Reich, M. H. Ellisman, D. H. Rowitch, J. R. Chan and K. Akassoglou (2017). <em>Neuron.</em> 96(5), 1003–1012 e1007. doi:10.1016/j.neuron.2017.10.008</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30478328/">Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development.</a> X. Yuan, M. Song, P. Devine, B. G. Bruneau, I. C. Scott and M. D. Wilson (2018). <em>Nat Commun.</em> 9(1), 4977. doi:10.1038/s41467-018-07451-z</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28351867/">Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites.</a> C. M. Anderson, J. Hu, R. Thomas, T. B. Gainous, B. Celona, T. Sinha, D. E. Dickel, A. B. Heidt, S. M. Xu, B. G. Bruneau, K. S. Pollard, L. A. Pennacchio and B. L. Blac. (2017). <em>Development.</em> 144(7), 1235–1241. doi:10.1242/dev.138487</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30342106/">An open-source control system for in vivo fluorescence measurements from deep-brain structures.</a> S. F. Owen and A. C. Kreitzer (2019). <em>J Neurosci Methods.</em> 311(170–177). doi:10.1016/j.jneumeth.2018.10.022</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31209378/">Thermal constraints on in vivo optogenetic manipulations.</a> S. F. Owen, M. H. Liu and A. C. Kreitzer (2019). <em>Nat Neurosci.</em> 22(7), 1061–1065. doi:10.1038/s41593-019-0422-3</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32096027/">Regulation of Tau Homeostasis and Toxicity by Acetylation.</a> T. Tracy, K. C. Claiborn and L. Gan (2019). <em>Adv Exp Med Biol.</em> 1184(47-55). doi:10.1007/978-981-32-9358-8_4</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31686033/">An Alzheimer’s-disease-protective APOE mutation.</a> K. A. Zalocusky, M. R. Nelson and Y. Huang. (2019). Nat Med, 25(11), 1648-1649. doi:10.1038/s41591-019-0634-9 23.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29402499/">Editorial overview: Neurobiology of disease (2018).</a> C. Bagni and A. C. Kreitzer (2018). <em>Curr Opin Neurobiol.</em> 48(iv-vi). doi:10.1016/j.conb.2018.01.005</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30258237/">Converging pathways in neurodegeneration, from genetics to mechanisms.</a> L. Gan, M. R. Cookson, L. Petrucelli and A. R. La Spada (2018). <em>Nat Neurosci.</em> 21(10), 1300–1309. doi:10.1038/s41593-018-0237-7</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29398356/">A Subpopulation of Striatal Neurons Mediates Levodopa-Induced Dyskinesia.</a> A. E. Girasole, M. Y. Lum, D. Nathaniel, C. J. Bair-Marshall, C. J. Guenthner, L. Luo, A. C. Kreitzer and A. B. Nelson (2018). <em>Neuron.</em> 97(4), 787–795 e786. doi:10.1016/j.neuron.2018.01.017</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30295606/">Motor thalamus supports striatum-driven reinforcement.</a> Lalive AL, Lien AD, Roseberry TK, Donahue CH, Kreitzer AC. <em>Elife.</em> 2018;7:e34032. Published 2018 Oct 8. doi:10.7554/eLife.34032</p> <p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972667/">Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination.</a> N. J. Lee, S. K. Ha, P. Sati, M. Absinta, N. J. Luciano, J. A. Lefeuvre, M. K. Schindler, E. C. Leibovitch, J. K. Ryu, M. A. Petersen, A. C. Silva, S. Jacobson, K. Akassoglou and D. S. Reich (2018). <em>Brain.</em> 141(6), 1637–1649. doi:10.1093/brain/awy082</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29527824/">Robust identification of deletions in exome and genome sequence data based on clustering of Mendelian errors.</a> K. B. Manheimer, N. Patel, F. Richter, J. Gorham, A. C. Tai, J. Homsy, M. T. Boskovski, M. Parfenov, E. Goldmuntz, W. K. Chung, M. Brueckner, M. Tristani-Firouzi, D. Srivastava, J. G. Seidman, C. E. Seidman, B. D. Gelb and A. J. Sharp (2018). <em>Hum Mutat.</em> 39(6), 870–881. doi:10.1002/humu.23419</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29425490/">Fast-Spiking Interneurons Supply Feedforward Control of Bursting, Calcium, and Plasticity for Efficient Learning.</a> S. F. Owen, J. D. Berke and A. C. Kreitzer (2018). <em>Cell.</em> 172(4), 683–695 e615. doi:10.1016/j.cell.2018.01.005</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30308164/">Pericytes: The Brain's Very First Responders?</a> V. A. Rafalski, M. Merlini and K. Akassoglou (2018). <em>Neuron.</em> 100(1), 11–13. doi:10.1016/j.neuron.2018.09.033</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30323343/">Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.</a> J. K. Ryu, V. A. Rafalski, A. Meyer-Franke, R. A. Adams, S. B. Poda, P. E. Rios Coronado, L. O. Pedersen, V. Menon, K. M. Baeten, S. L. Sikorski, C. Bedard, K. Hanspers, S. Bardehle, A. S. Mendiola, D. Davalos, M. R. Machado, J. P. Chan, I. Plastira, M. A. Petersen, S. J. Pfaff, K. K. Ang, K. K. Hallenbeck, C. Syme, H. Hakozaki, M. H. Ellisman, R. A. Swanson, S. S. Zamvil, M. R. Arkin, S. H. Zorn, A. R. Pico, L. Mucke, S. B. Freedman, J. B. Stavenhagen, R. B. Nelson and K. Akassoglou (2018). <em>Nat Immunol.</em> 19(11), 1212–1223. doi:10.1038/s41590-018-0232-x</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30415806/">Military-related risk factors for dementia.</a> H. M. Snyder, R. O. Carare, S. T. DeKosky, M. J. de Leon, D. Dykxhoorn, L. Gan, R. Gardner, S. R. Hinds, 2nd, M. Jaffee, B. T. Lamb, S. Landau, G. Manley, A. McKee, D. Perl, J. A. Schneider, M. Weiner, C. Wellington, K. Yaffe, L. Bain, A. M. Pacifico and M. C. Carrillo (2018). <em>Alzheimers Dement.</em> 14(12), 1651–1662. doi:10.1016/j.jalz.2018.08.011</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30007419/">A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice.</a> F. Sun, J. Zeng, M. Jing, J. Zhou, J. Feng, S. F. Owen, Y. Luo, F. Li, H. Wang, T. Yamaguchi, Z. Yong, Y. Gao, W. Peng, L. Wang, S. Zhang, J. Du, D. Lin, M. Xu, A. C. Kreitzer, G. Cui and Y. Li (2018). <em>Cell.</em> 174(2), 481–496 e419. doi:10.1016/j.cell.2018.06.042</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29753269/">Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease.</a> T. E. Tracy and L. Gan (2018). <em>Curr Opin Neurobiol.</em> 51(134–138). doi:10.1016/j.conb.2018.04.027</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30053424/">The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.</a> A. J. Willsey, M. T. Morris, S. Wang, H. R. Willsey, N. Sun, N. Teerikorpi, T. B. Baum, G. Cagney, K. J. Bender, T. A. Desai, D. Srivastava, G. W. Davis, J. Doudna, E. Chang, V. Sohal, D. H. Lowenstein, H. Li, D. Agard, M. J. Keiser, B. Shoichet, M. von Zastrow, L. Mucke, S. Finkbeiner, L. Gan, N. Sestan, M. E. Ward, R. Huttenhain, T. J. Nowakowski, H. J. Bellen, L. M. Frank, M. K. Khokha, R. P. Lifton, M. Kampmann, T. Ideker, M. W. State and N. J. Krogan (2018). <em>Cell.</em> 174(3), 505–520. doi:10.1016/j.cell.2018.06.016</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30413620/">Klotho controls the brain-immune system interface in the choroid plexus.</a> L. Zhu, L. R. Stein, D. Kim, K. Ho, G. Q. Yu, L. Zhan, T. E. Larsson and L. Mucke (2018). <em>Proc Natl Acad Sci U S A.</em> 115(48), E11388-E11396. doi:10.1073/pnas.1808609115</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29118209/">In Vivo Imaging of CNS Injury and Disease.</a> K. Akassoglou, M. Merlini, V. A. Rafalski, R. Real, L. Liang, Y. Jin, S. E. Dougherty, V. De Paola, D. J. Linden, T. Misgeld and B. Zheng (2017). <em>J Neurosci.</em> 37(45), 10808–10816. doi:10.1523/JNEUROSCI.1826-17.2017</p> <h2>Core-led Publications</h2> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32111148/">Single-Cell Determination of Cardiac Microtissue Structure and Function Using Light Sheet Microscopy.</a> D. Turaga, O. B. Matthys, T. A. Hookway, D. A. Joy, M. Calvert and T. C. McDevitt (2020). <em>Tissue Eng Part C Methods.</em> doi:10.1089/ten.TEC.2020.0020</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29389399/">Lightsheet fluorescence microscopy of branching human fetal kidney.</a> D. Isaacson, J. Shen, D. McCreedy, M. Calvert, T. McDevitt, G. Cunha and L. Baskin (2018). <em>Kidney Int.</em> 93(2), 525. doi:10.1016/j.kint.2017.09.010</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32111148/">Single-Cell Determination of Cardiac Microtissue Structure and Function Using Light Sheet Microscopy.</a> D. Turaga, O. B. Matthys, T. A. Hookway, D. A. Joy, M. Calvert and T. C. McDevitt (2020). <em>Tissue Eng Part C Methods.</em> doi:10.1089/ten.TEC.2020.0020</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31634681/">Imaging the developing human external and internal urogenital organs with light sheet fluorescence microscopy.</a> D. Isaacson, D. McCreedy, M. Calvert, J. Shen, A. Sinclair, M. Cao, Y. Li, T. McDevitt, G. Cunha and L. Baskin (2020). <em>Differentiation.</em> 111(12–21). doi:10.1016/j.diff.2019.09.006</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30262218/">Three-dimensional imaging of the developing human fetal urogenital-genital tract: Indifferent stage to male and female differentiation.</a> D. Isaacson, J. Shen, M. Overland, Y. Li, A. Sinclair, M. Cao, D. McCreedy, M. Calvert, T. McDevitt, G. R. Cunha and L. Baskin (2018). <em>Differentiation.</em> 103(14–23). doi:10.1016/j.diff.2018.09.003</p> <p class="cntrbutt"><a class="morepub button outline">More Publications</a></p> </div> <div class="corebk4">   </div> </section> <section id="equipment"> <div id="equip-intro" class="container"> <h2 class="tabtop">Equipment</h2> <p class="large" data-pm-slice="1 1 []">Learn how our experts can support your research.</p> </div> <div id="lightsheet" class="scopecat"> <div class="container"> <h3>Lightsheet/Single Plane Illumination Microscopy</h3> <div class="col-sm-5"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-lightsheet_img js-view-dom-id-256c50de5ff05c114a259da348bd7d5e9b6ccf086f369bda01df081204f4736e"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2021-10/zeiss_z1-lightsheet-_finwhale.jpg" id="30423042" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-3042">Fin Whale (Zeiss Z1 Light Sheet Microscope)</div></div></div></div> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2024-07/miltenyiblaze.jpg" id="93329332" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-9332">Miltenyi Blaze</div></div></div></div> </div> </div> </div> </div> <div class="col-sm-7"> <div class="accordion-wrapper"> <div class="accordion-div"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-lightsheet js-view-dom-id-56ad956c50d149e90e6d36dcd14ee123aa8806d569505bf17c87737122985657"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="3042" class="accordion"> <h4>Fin Whale Zeiss Z1 Light Sheet Microscope</h4> </div> <div class="panel"> <ul><li>Light Sheet Fluorescence Microscope<ul><li>For both aqueous and cleared samples</li><li>Dual cameras for 2-color simultaneous acquisition (405nm, 488nm, 561nm, 640nm lasers)</li></ul></li><li>Sample requirements:<ul><li>Typically embedded in agarose; either aqueous or pre-cleared (Clarity, PACT, etc.)</li><li>Samples usually fluorescently labeled</li><li>Sample preparation can require extensive optimization</li></ul></li><li>Suitable applications:<ul><li>High-speed fixed or live-cell imaging (>100fps)</li><li>Imaging large, thick samples at high resolution with extremely low-bleach, low phototoxicity</li><li>Long-term live-cell imaging (>6 hours)</li><li>Isotropic resolution- best possible 3D reconstruction</li></ul></li><li>Not good for:<ul><li>High magnification (max = 40x)</li><li>Imaging large, thick samples at high resolution with extremely low-bleach, low phototoxicity</li></ul></li><li>Does the core provide training on this equipment? Yes</li></ul> <p id="manu-butt"><a href="https://www.zeiss.com/microscopy/us/products/imaging-systems/lightsheet-z-1.html" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="9332" class="accordion"> <h4>Miltenyi Blaze Ultra-Imaging 3D Light Sheet Microscope</h4> </div> <div class="panel"> <p>Light Sheet Microscope:</p> <ul> <li>Immersion objectives: 1.1X and 4X (0.6X – 10X total range) Camera: 4.2 Mpx sCMOS (2048 x 2048 pixels)</li> <li>5 lasers: 405, 488, 561, 639, 785nm</li> <li>Sample travel range : 24mm (X) x 50 mm (Y) x 23mm (Z)*</li> <li>Up to 6 light sheets (3 x 2 dual side) for optical sectioning</li> <li>Adjustable light sheet thickness: 4 – 24 μm (NA 0.0135 – 0.135)</li> </ul> <p>*Z-range constrained by objective working distance (≥16 mm for 1.1X, ≥15 mm for 4X)</p> <p>Sample types:</p> <ul> <li>Pre-cleared sample (aqueous buffers and organic solvents with RI 1.33 – 1.57)</li> <li>Organoids to adult mouse</li> </ul> <p>Application:</p> <ul> <li>Imaging (multiple) small to large samples in 3D with low photobleaching and high relative speed</li> </ul> <p>Not good for:</p> <ul> <li>Live imaging</li> <li>Structures needing to be resolved with greater that 10X magnification.</li> </ul> <p id="manu-butt"></p> </div> </div></div></div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="confocal" class="scopecat"> <div class="container"> <h3>Confocal Microscopy</h3> <div class="col-sm-5"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-confocal_img js-view-dom-id-107690ffb2ac10b6aaf6c363fab87adca7ab29fbd6c63aa1d174d0bfb3aba533"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2021-10/olympus_fv3000rs-snow_leopard.jpg" id="65836583" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-6583">Snow Leopard (Olympus Fluoview FV3000)</div></div></div></div> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2021-10/zeiss_lsm880_with_airyscan-tarsier.jpg" id="33063306" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-3306">Tarsier (Zeiss LSM880 Super-Resolution AiryScan Confocal Microscope)</div></div></div></div> </div> </div> </div> </div> <div class="col-sm-7"> <div class="accordion-wrapper"> <div class="accordion-div"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-confocal js-view-dom-id-e8d5b46b9fbdf049e7303d3258adeb51b28735f3c3459654e89d59257cd8c6b0"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="6583" class="accordion"> <h4>Snow Leopard (Olympus Fluoview FV3000)</h4> </div> <div class="panel"> <ul> <li>Specifications: <ul> <li>Point-scanning confocal microscope</li> <li>Both Galvo & Resonance scanning for high speed imaging</li> <li>Multiple laser lines (405nm, 445nm, 488nm, 514nm, 594nm, 561nm, 638nm)</li> <li>Definite focus with Z drift correction function</li> <li>Inverted microscope with motorized (x,y,Z) stage</li> <li>>Incubation chamber (CO2, Temperature & Humidity) for both short & long live cell/tissue imaging</li> </ul> </li> <li>Sample types <ul> <li>Chamber slides, 35mm dishes or optical-quality well plates</li> <li>Combo 35mm & Chambered slide holder</li> <li>Both live & fixed tissues/cells</li> </ul> </li> <li>Applications: <ul> <li>Scanning confocal imaging for live and fixed -cell, organoid and tissue imaging</li> <li>Live-cell fluorescence dynamics (i.e. FRAP, FRET, GCaMP)</li> <li>Imaging individual cells at high resolution, any magnification</li> <li>Multipositional acquisition and tiling multiple images for large sample areas</li> </ul> </li> <li>Not good for: <ul> <li>Very thick samples (>100µm)</li> <li>Very high-speed imaging (>10fps)</li> </ul> </li> </ul> <p id="manu-butt"><a href="https://www.olympus-lifescience.com/en/laser-scanning/fv3000/" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="3306" class="accordion"> <h4>Tarsier (Zeiss LSM880 Super-Resolution AiryScan Confocal Microscope)</h4> </div> <div class="panel"> <ul><li>Specifications:<ul><li>Point-scanning confocal microscope</li><li>Airyscan detector for increased resolution (>120nm lateral), sensitivity</li><li>Multiple laser lines (405nm, 445nm, 488nm, 514nm, 561nm, 638nm)</li><li>Definite focus</li><li>Objective inverter for using dipping lenses</li></ul></li><li>Sample types:<ul><li>Chamber slides</li><li>35mm dishes</li><li>Optical-quality well plates</li></ul></li><li>Applications:<ul><li>Scanning confocal imaging for mid-speed (13 fps) live-cell imaging</li><li>Live-cell fluorescent dynamics (i.e. FRAP, FRET, GCaMP)</li><li>Imaging individual cells at high resolution, any magnification</li><li>Multipositional acquisition and tiling multiple images for large sample areas</li></ul></li><li>Not good for:<ul><li>Very thick samples (>100µm)</li><li>Very high-speed imaging (>10fps)</li></ul></li></ul> <p id="manu-butt"><a href="https://www.zeiss.com/microscopy/us/products/confocal-microscopes/lsm-880-with-…" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> </div> <div class="view-footer"> <style> #33093309,#33083308{display:none} </style> </div> </div> </div> </div> </div> </div> </div> </div> <div id="widefield" class="scopecat"> <div class="container"> <h3>Widefield Microscopy</h3> <div class="col-sm-5"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-histology_widefield_image js-view-dom-id-55eaf08f571e6aeba9c29ce3923329b42453db6609ed78845be32883034434fb"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2021-10/leica_aperio-slide_scanner-octopus.jpg" id="33093309" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-3309"> Octopus: Leica Versa 200 Automated Slide Scanner</div></div></div></div> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2021-10/keyence_microscope-coyote1.jpg" id="30433043" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-3043"> Coyote 1 (Keyence epifluorescence BZX810 )</div></div></div></div> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2021-10/keyence_microscope-_coyote3.jpg" id="65846584" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-6584"> Coyote 2 and 3 (Keyence epifluorescence BZ9000 )</div></div></div></div> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2021-10/zeiss-_cuttlefish.jpg" id="65856585" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-6585"> Cuttlefish (Zeiss AxioObserver Z1 Inverted Microscope)</div></div></div></div> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2021-10/michael_short_-_galdstone8-3-30_028.jpg" id="33083308" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-3308"> Tortoise (Zeiss Live Cell Inverted Epifluorescence Microscope)</div></div></div></div> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2021-10/nikon_microscope-_chameleon_0.jpg" id="30393039" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-3039"> Cameleon (Nikon Eclipse E600 Upright Microscope)</div></div></div></div> </div> </div> </div> </div> <div class="col-sm-7"> <div class="accordion-wrapper"> <div class="accordion-div"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-histology_widefield js-view-dom-id-2ad65c5004a35365be1ece52b0dba0f89a6268da3bf507437178cbb0c4f33fe2"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="3309" class="accordion"> <h4>Octopus: Leica Versa 200 Automated Slide Scanner</h4> </div> <div class="panel"> <ul> <li>Specifications: <ul> <li>Automated slide scanner with wide-field fluorescence and brightfield imaging</li> <li>Metal halide illumination; filters for DAPI, GFP, RFP, and Cy5</li> <li>High sensitivity RGB and monochrome camera</li> <li>5x, 10x, 20x, 40x air objectives and 63x oil objective (with auto-oiler)</li> </ul> </li> <li>Sample types: <ul> <li>Slides / high throughput</li> </ul> </li> <li>Applications: <ul> <li>Automated whole slide imaging for up to 200 slides per run</li> <li>Multipositional acquisition and tiling for large sample areas</li> </ul> </li> <li>Not good for: <ul> <li>Long term live-cell imaging</li> <li>Thick samples (>50um)</li> </ul> </li> <li>Does the core provide training on this equipment? Yes</li> </ul> <p id="manu-butt"><a href="https://www.leicabiosystems.com/digital-pathology/aperio-digital-pathology-slid…" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="3043" class="accordion"> <h4>Coyote 1 (Keyence epifluorescence BZX810 )</h4> </div> <div class="panel"> <ul> <li>Specifications: <ul> <li>Automated inverted wide-field epifluorescence and brightfield imaging system</li> <li>Metal halide illumination; filters for DAPI, GFP, RFP, and Cy5</li> <li>High sensitivity RGB and monochrome camera</li> </ul> </li> <li>Sample types: <ul> <li>Slides or 35mm dishes</li> <li>Tissue culture plates</li> <li>Petri dishes</li> </ul> </li> <li>Applications: <ul> <li>Epifluorescence imaging for fixed and live-cell samples</li> <li>Multipositional acquisition and tiling multiple images for large sample areas</li> <li>Structured illumination for increased resolution (pseudo-confocal)</li> <li>Phase contrast and oblique illumination for high contrast brightfield imaging</li> </ul> </li> <li>Not good for: <ul> <li>Long term live-cell imaging</li> <li>Thick samples (>50um)</li> </ul> </li> </ul> <p id="manu-butt"><a href="https://www.keyence.com/ss/products/microscope/bz-x700/index.jsp" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="6584" class="accordion"> <h4>Coyote 2 & 3 (Keyence epifluorescence BZ9000)</h4> </div> <div class="panel"> <ul> <li>Specifications: <ul> <li>Automated wide-field epifluorescence system</li> <li>Metal halide illumination; filters for DAPI, GFP, RFP, and Cy5</li> </ul> </li> <li>Sample types: <ul> <li>Slides</li> <li>35mm dishes</li> </ul> </li> <li>Applications: <ul> <li>Epifluorescence imaging for fixed and live-cell samples</li> <li>Tiling multiple images for large sample areas</li> </ul> </li> <li>Not good for: <ul> <li>Long term live-cell imaging</li> <li>Thick samples (>50um)</li> <li>Plastic tissue culture plates</li> </ul> </li> </ul> <p id="manu-butt"><a href="https://www.keyence.com/ss/products/microscope/bz-casestudy/" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="6585" class="accordion"> <h4>Cuttlefish (Zeiss AxioObserver Z1 Inverted Microscope)</h4> </div> <div class="panel"> <ul> <li>Specifications: <ul> <li>Wide-field epifluorescence system for fixed and live-cell imaging</li> <li>Metal halide illumination; filters for DAPI, GFP, RFP, and Cy5</li> <li>Definite focus, motorized stage, and stable incubation (temperature and CO2 control)</li> <li>Polarizing filter for imaging birefringence</li> </ul> </li> <li>Sample types: <ul> <li>Slides</li> <li>35mm dishes</li> <li>Tissue culture well plates</li> </ul> </li> <li>Applications: <ul> <li>Long-term live-cell imaging experiments</li> <li>Multipositional acquisition and tiling multiple images for large sample areas</li> </ul> </li> <li>Not good for: <ul> <li>High-speed live-cell imaging</li> <li>Thick samples (>50um)</li> </ul> </li> </ul> <p id="manu-butt"><a href="https://www.zeiss.com/microscopy/us/products/light-microscopes/axio-observer-fo…" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="3308" class="accordion"> <h4>Tortoise (Zeiss Live Cell Inverted Epifluorescence Microscope)</h4> </div> <div class="panel"> <ul> <li>Specifications: <ul> <li>Wide-field inverted epifluorescence system for fixed and live cell imaging</li> <li>Metal halide illumination; filters for DAPI, GFP, RFP, and Cy5</li> <li>Motorized stage and full incubation (temperature and CO2 control)</li> <li>Flash4.0 sCMOS camera for low-light and high-speed imaging</li> </ul> </li> <li>Sample types: <ul> <li>Slides</li> <li>35mm dishes</li> <li>Tissue culture well plates</li> </ul> </li> <li>Applications: <ul> <li>Epifluorescence imaging for fixed and live-cell samples</li> <li>Short term time-lapse imaging</li> <li>Multipositional acquisition and tiling multiple images for large sample areas</li> </ul> </li> <li>Not good for: <ul> <li>Long term live-cell imaging</li> <li>Thick samples (>50um)</li> </ul> </li> </ul> <p id="manu-butt"><a href="https://www.zeiss.com/microscopy/us/products/light-microscopes/axio-observer-fo…" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="3039" class="accordion"> <h4>Cameleon (Nikon Eclipse E600 Upright Microscope)</h4> </div> <div class="panel"> <ul> <li>Specifications: <ul> <li>Wide-field upright epifluorescence and full-color brightfield imaging system</li> <li>Metal halide illumination; filters for DAPI, FITC, and Texas Red</li> <li>RGB and monochrome Retiga camera with Qcapture acquisition software</li> </ul> </li> <li>Sample types: <ul> <li>Slides</li> </ul> </li> <li>Applications: <ul> <li>Epifluorescence and brightfield imaging for fixed samples</li> </ul> </li> <li>Not good for: <ul> <li>Live-cell imaging</li> <li>Tissue cultures plates and dishes</li> <li>Time-lapse microscopy</li> <li>Low-light fluorescence imaging</li> </ul> </li> </ul> <p id="manu-butt"><a href="https://microscopecentral.com/products/nikon-eclipse-e600-fluorescence-microsco…" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> </div> <div class="view-footer"> <style> #33093309,#33083308{display:none} </style> </div> </div> </div> </div> </div> </div> </div> </div> <div id="tissue-processor" class="scopecat"> <div class="container"> <h3>Tissue Processor: AS</h3> <div class="col-sm-5"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-tissue_proc_img js-view-dom-id-381401277b383684972cf7d3486cf328f2c409a0501532a508b6a0dcf15e6160"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2023-09/shandon-histocenter-3.jpg" id="86268626" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-8626"> . </div></div></div></div> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2023-09/excelsioras-tissue-processor.jpg" id="86278627" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-8627"> A82300001A Excelsior AS Tissue Processor with Line Conditioner</div></div></div></div> </div> </div> </div> </div> <div class="col-sm-7"> <div class="accordion-wrapper"> <div class="accordion-div"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-tissue_proc js-view-dom-id-34ee54cb7a2317b2d73165400535b3050492e46b282b87b75e7a4a442c5ed586"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="8626" class="accordion"> <h4>Epredia Histostar Embedding Station </h4> </div> <div class="panel"> <ul> <li>Specifications: <ul> <li>Smart histology embedding module</li> <li>Paraffin machine</li> <li>Paraffin Wax embedding station</li> </ul> </li> <li>Sample types: <ul> <li>All types of tissues including fatty tissues</li> </ul> </li> <li>Applications: <ul> <li>Alcohol quality measurement enables you to extend your reagent life and provides significant cost savings</li> <li>Automatic reagent rotation further extends reagent life using a proven system</li> </ul> </li> <li>Does the core provide training on this equipment? No</li> </ul> <p id="manu-butt"></p> </div> </div></div></div> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="8627" class="accordion"> <h4>A82300001A Excelsior AS Tissue Processor with Line Conditioner</h4> </div> <div class="panel"> <ul> <li>Specifications: <ul> <li>Automatically prepare tissue samples for laboratory testing, by fixing, dehydrating, clearing, and infiltrating them with paraffin</li> <li>Enhanced tissue quality</li> <li>Preheating reagents up to 35°C, minimizing tissue shock and facilitating reagent penetration</li> </ul> </li> <li>Sample types: <ul> <li>All types of tissues including fatty tissues</li> </ul> </li> <li>Applications: <ul> <li>Alcohol quality measurement enables you to extend your reagent life and provides significant cost savings</li> <li>Automatic reagent rotation further extends reagent life using a proven system</li> </ul> </li> <li>Does the core provide training on this equipment? No</li> </ul> <p id="manu-butt"><a href="https://www.fishersci.com/shop/products/excelsior-as-tissue-processor-3/A82300001A" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> </div> <div class="view-footer"> <style> #33093309,#33083308{display:none} </style> </div> </div> </div> </div> </div> </div> </div> </div>  <div id="microtomes" class="scopecat"> <div class="container"> <h3>Microtomes</h3> <div class="col-sm-5"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-microtomes_img js-view-dom-id-32b24d3a8bbd47e5e2dc808c495ac5cf84d766ffe216a540360b3371cec50fb6"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2024-07/leicarm2245.jpg" id="86308630" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-8630"> Leica RM2245 Automatic Microtome</div></div></div></div> </div> </div> </div> </div> <div class="col-sm-7"> <div class="accordion-wrapper"> <div class="accordion-div"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-microtomes js-view-dom-id-f89ed3d07c05c941930c4b8e77c27f119a7c5f03cff4f28fb6071833cedfaef3"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="8630" class="accordion"> <h4>Leica RM2245 Automatic Microtome</h4> </div> <div class="panel"> <ul> <li>Specifications: <ul> <li>The RM2245 is a semi-motorized rotary microtome, designed for routine in histopathology</li> <li>Manual sectioning is enhanced by a high-precision motorized specimen feed, which results in efficient operation with maximum section quality and reproducibility</li> </ul> </li> <li>Application: <ul> <li>Choose between conventional, full-hand-wheel rotation, manual sectioning or "rocking mode".</li> <li>Motorized sectioning and meets the many requirements of modern laboratories</li> </ul> </li> <li>Does the core provide training on this equipment? Yes</li> </ul> <p id="manu-butt"></p> </div> </div></div></div> </div> <div class="view-footer"> <style> #33093309,#33083308{display:none} </style> </div> </div> </div> </div> </div> </div> </div> </div> <div id="cryostats" class="scopecat"> <div class="container"> <h3>Cryostats</h3> <div class="col-sm-5"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-cryostats_img js-view-dom-id-b1cff016d2c6b3175f75eb151cf14caf9cab2b993b732e9d7a62e25b16d0e393"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2023-09/cryostar-nx50.jpg" id="86328632" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-8632"> CryoStar NX50 Cryostat Instrument (Epredia)</div></div></div></div> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2023-09/epredia-cryostar-nx70.jpg" id="86318631" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-8631"> CryoStar NX70 Cryostat Instrument (Epredia)</div></div></div></div> </div> </div> </div> </div> <div class="col-sm-7"> <div class="accordion-wrapper"> <div class="accordion-div"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-cryostats js-view-dom-id-44c2a4a432d25af192c626a556282d7505002f9a0a2f90e958f50de53199181a"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="8632" class="accordion"> <h4>CryoStar NX50 Cryostat Instrument (Epredia)</h4> </div> <div class="panel"> <ul> <li>Does the core provide training on this equipment? Yes</li> </ul> <p id="manu-butt"></p> </div> </div></div></div> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="8631" class="accordion"> <h4>CryoStar NX70 Cryostat Instrument (Epredia)</h4> </div> <div class="panel"> <ul> <li>Specifications: <ul> <li>A form-fitting design, integrated height control, and motorized sectioning</li> <li>Adjustable cutting speed from 0 mm/s to 256 mm/s</li> <li>Section thickness from 0.5 µm to 500 µm</li> <li>Vertical stroke length of 64 mm</li> <li>48 mm horizontal feed range</li> <li>20 µm specimen retraction on return stroke, with optical indication</li> </ul> </li> <li>Applications: <ul> <li>Mounting tissue to ready-to-cut with quick freeze and setup features</li> <li>Section tissue samples more efficiently with improved stability and individually controlled temperature settings on both the object holder and blade carrier</li> </ul> </li> <li>Does the core provide training on this equipment? No</li> </ul> <p id="manu-butt"><a href="https://epredia.com/pdf/cryotomy/cryostar-NX70/" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> </div> <div class="view-footer"> <style> #33093309,#33083308{display:none} </style> </div> </div> </div> </div> </div> </div> </div> </div> <div id="stainer" class="scopecat"> <div class="container"> <h3>Coverslipper</h3> <div class="col-sm-5"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-stainer_img js-view-dom-id-88e0fbc12f0543d76a7eef78d6fa663c7d08afd7c3639ae93dff09a771155e3a"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-equipment-image"><div class="field-content"><img src="/sites/default/files/2023-09/Leica-CV-5030.jpg" id="86348634" /></div></div><div class="views-field views-field-field-equipment-image-1"><div class="field-content"><div class="caption" id="caption-8634">Leica Cover Slipper</div></div></div></div> </div> </div> </div> </div> <div class="col-sm-7"> <div class="accordion-wrapper"> <div class="accordion-div"> <div class="views-element-container"><div class="view view-equipment view-id-equipment view-display-id-stainer js-view-dom-id-31bfe7b6427dc7d7cb13104a05dcc31c61415a8b6519c00e268033ff68816c19"> <div class="view-header"> <style> .view-display-id-confocal #3040 {visibility:hidden !important} </style> </div> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-description"><div class="field-content"><div id="8634" class="accordion"> <h4>Leica ST5020 Cover Slipper</h4> </div> <div class="panel"> <ul> <li>Specifications <ul> <li>Integration into staining/coverslipping workstations to form a fully automated</li> <li>Coverslips at a rate of 300 slides per hour using standard microscope slides and glass coverslips of different sizes to increase productivity and efficiency in the lab.</li> </ul> </li> </ul> <p id="manu-butt"><a href="https://www.leicabiosystems.com/us/histology-equipment/he-slide-stainers-special-stainers-coverslippers/leica-cv5030/" class="button navy" target="_blank">Manufacturer Site</a></p> </div> </div></div></div> </div> <div class="view-footer"> <style> #33093309,#33083308{display:none} </style> </div> </div> </div> </div> </div> </div> </div> </div>  <div id="block-donate" class="clearfix block block-block-content block-block-content088590df-5b08-415b-9ea8-aba4578a4a67"> <div class="content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="container"> <h2>Support Discovery Science</h2> <p>Your gift to Gladstone will allow our researchers to pursue high-quality science, focus on disease, and train the next generation of scientific thought leaders.</p> <p><a class="button magenta" href="https://gladstone.org/make-a-gift">Donate Now</a></p> </div> </div> </div> </div> </section> <section id="faqs"> <div class="accordion-wrapper"> <div class="container"> <h2>FAQs</h2> <div class="accordion accord1"><h3>How Do I Create an iLab Account?</h3></div> <div class="panel"> <p>If you're a UC San Francisco user, <a href="https://help.ilab.agilent.com/99540-getting-started-with-ilab/325013-registering-with-ilab" target="_blank">learn how to create an account with iLab.</a></p> <p>If you’re part of a nonprofit organization or a for-profit company, you’ll need to sign a legal service agreement (LSA). Once the LSA is signed by both organizations, you’ll receive instructions on how to set up an iLab account to request services. <a href="mailto:histology@gladstone.ucsf.edu" rel="noopener" target="_blank">Contact the core</a> to start the LSA process.</p> </div> <div class="accordion"><h3>How Can I Get a Quote for My Project?</h3></div> <div class="panel"> <ol> <li><a href="https://my.ilabsolutions.com/account/login">Login into your iLab account</a></li> <li>Initiate a service request</li> <li>Use the temporary PO number 11111 to finalize and submit your service request</li> <li><a href="mailto:histology@gladstone.ucsf.edu">Email the core</a> after your service request is submitted with the temporary PO to receive a formal quote</li> <li>Use the quote to generate a formal PO by your lab or organization’s financial department</li> <li>Use the valid PO to update your iLab account profile and billing or financial information</li> <li><a href="mailto:histology@gladstone.ucsf.edu">Email the core a PDF copy of your formal PO</a></li> </ol> <p>If you need help generating or submitting your PO, reach out to your lab’s grant or financial manager.</p> </div> <div class="accordion"><h3>How Do I Get a Consultation?</h3></div> <div class="panel"> <p><a href="mailto:histology@gladstone.ucsf.edu">Contact the core to schedule a consultation</a></p> </div> <div class="accordion"><h3>How Do I Pay for Services?</h3></div> <div class="panel"> <p>When you <a href="https://gladstone.corefacilities.org/account/signup/34?sc_id=2929" rel="noopener" target="_blank">create an iLab account</a>, you will provide a valid PO. We do not accept credit cards or cash.</p> </div> <div class="accordion"><h3>Who Can Access the Core’s Services and Instruments?</h3></div> <div class="panel"> <p>The core’s services are available to both Gladstone and outside researchers.</p> </div> <div class="accordion"><h3>Can I Use the Core Equipment Independently?</h3></div> <div class="panel"> <p>Users can use some of the core equipment once they are trained and granted access by the core’s staff. Only formally trained users are allowed to use our core’s equipment.</p> </div> <div class="accordion"><h3>What If I Already Have Experience Using Microscopes and Other Instruments?</h3></div> <div class="panel"> <p>In order to independently use the core’s microscopes and instruments, you must schedule a training session during which core staff will evaluate your experience and determine whether a second session is needed before gaining full access to the core’s equipment.</p> </div> <div class="accordion"><h3>How Do I Request Services or Training?</h3></div> <div class="panel"> <p>Visit iLab and <a href="https://help.ilab.agilent.com/37179-using-a-core/265959-request-services" rel="noopener" target="_blank">fill out the instrument training request.</a> After you send the request, it typically takes 1–2 weeks to schedule a training session.</p> <p>Our training protocol is a 2-step process. The first session is more general and covers care and handling of the microscope. The second session is focused on your specific project needs. At the end of these two training sessions, the core will evaluate your comfort level with the microscope before granting “assisted/dependent” or “unassisted/independent” user status with full access to the calendar.</p> </div> <div class="accordion"><h3>How Do I Schedule or Make an Equipment Reservation?</h3></div> <div class="panel"> <p><a href="https://help.ilab.agilent.com/37179-using-a-core/264636-schedule-equipment" target="_blank">Visit iLab to schedule a reservation.</a></p> </div> <div class="accordion"><h3>How Do I Drop Off and Pick Up My Samples?</h3></div> <div class="panel"> <p>Sample drop-off<br /> To drop off your samples, stop by the core located in room 367 at Gladstone Institutes, between 10am–3pm.</p> <ul> <li>FFPE samples:  <ul> <li style="list-style-type:circle;">You should fix your samples (in 4 percent PFA or 10 percent formalin), rinse (3x) in 1x PBS, and store in 70 percent EtOH, before bringing to the core.</li> <li style="list-style-type:circle;">Gradually increase EtOH ethanol concentration: 25 percent, 50 percent, and finally 70 percent EtOH approach is preferable or recommended.</li> </ul> </li> <li style="list-style-type:disc;">Frozen tissues: Samples can be brought to the core in one of the following conditions: <ul> <li style="list-style-type:circle;">In 30% sucrose (transported on ice)</li> <li style="list-style-type:circle;">In OCT blocks or tissues slides (transported on dried ice)</li> </ul> </li> </ul> <p><a href="mailto:histology@gladstone.ucsf.edu" rel="noopener" target="_blank">Contact the core</a> for the 10x Genomics Visium sample preparation</p> <p>Sample pick-up<br /> The core will let you know when your samples are ready. When they are ready for pick-up, stop by room 367 at Gladstone Institutes, between 10am–3pm.</p> </div> <div class="accordion"><h3>Can Samples Be Sent by Mail?</h3></div> <div class="panel"> <p>All samples must be dropped off in person. To drop off your samples, stop by the core located in room 367 at Gladstone Institutes, between 10am–3pm</p> </div> <div class="accordion"><h3>How Do I Know When My Samples Are Ready?</h3></div> <div class="panel"> <p>You will be notified by iLab mail. Pick up by the drop-off area, in room 367 at Gladstone Institutes. Remember to pick up your antibodies as well!</p> </div> <div class="accordion"><h3>How Long Will It Take for My Request to Be Completed?</h3></div> <div class="panel"> <p>Standard turn-around time is typically 10–20 business days from the date the samples are dropped off and received by the core (not the project submission date via iLab), depending on the size of the order and how many requests we have in our queue.</p> <p>Rush order turn-around is 5–10 days</p> <p>Note that these are estimates and turn-around times can be longer due to the complexity and size of the project and our current workload.</p> </div> <div class="accordion"><h3>Does the Core Provide Pathology Assessment?</h3></div> <div class="panel"> <p>Our core does not provide pathology assessment.</p> </div> <div class="accordion"><h3>What Type of Tissue Can Be Submitted to the Core for Processing?</h3></div> <div class="panel"> <p>We accept a large variety of tissue types including regular soft tissues as well as bones, cells, and organoids pre-embedded in histogel or in suspension. All tissues must be fixed prior to submission.</p> </div> <div class="accordion"><h3>Should I Fix My Samples Prior to Submitting Them to the Core, and What Is the Best Way to Fix Them?</h3></div> <div class="panel"> <p>Yes, all tissue should be fixed prior to submission. Most tissues do well with fresh perfusion followed by 4 percent PFA or 10 percent formalin fixation overnight in the fridge. Common exceptions are brain and bone samples, which require extended fixation.</p> </div> <div class="accordion"><h3>Will Paraffin Blocks Be Returned after Completing the Request? </h3></div> <div class="panel"> <p>Yes.</p> </div> <div class="accordion"><h3>When Should I Cite a Core Facility in a Publication, Presentation, or Poster?</h3></div> <div class="panel"> <p>We ask that you be generous with your citations. 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