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Platform - Luminary Therapeutics
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This allogeneic manufacturing platform has three components, gamma delta 1 and gamma delta 2 T cells are combined in the final therapeutic product, a non-viral gene modification process, and an immune cloaking capability." /> <link rel="canonical" href="https://www.luminarytx.com/platform/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Platform - Luminary Therapeutics" /> <meta property="og:description" content="Luminary is keenly focused on overcoming the key challenges facing the CAR T industry namely solid tumor resistance, manufacturing hurdles, and antigen escape. Luminary has a novel one-of-a-kind allogeneic T cell manufacturing platform. Luminary's allogeneic solution is built on a manufacturing platform called Gamma 2.0+. 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class="page_title breadcrumb-overlay header1" style="background-image: url(https://www.luminarytx.com/wp-content/uploads/luminary_header-e1650052735702.png);"> <div class="container"> <div class="row"> <div class="col-md-12"> <h5 class="page_tittle activebreadcrumbColor">PLATFORM</h5> <!-- Breadcrumb --> <div class="bread_crumb text-lg-left"> <a href="https://www.luminarytx.com/"> Home<i class="fa fa-angle-right pl-2" aria-hidden="true"></i> </a> <span class="activeColor">PLATFORM</span> </div> <!-- End Breadcrumb --> </div> </div> </div> </div> <!-- breadcumb-area-end --> <!-- blog section start --> <div id="blog" class="blog-page section-space"> <div class="container"> <div class="row"> <div class="col-lg-12 mx-auto col-md-12 col-sm-12 col-12 "> <div id="post-425" class="post-425 page type-page status-publish hentry"> <div class="entry-content"> <section class="vc_section"><div class="vc_row section-element padding-80"> <div class="vc_col-sm-6 "> <div class="wpb_text_column wpb_content_element "> <div class="section-title"> <div class="section-thumb"><img decoding="async" src="https://www.luminarytx.com/wp-content/uploads/site-icon.png" alt="title-icon" /></div> <h6 class="sub-title activeColor" style="padding-left: 60px;">State of the Art Platform</h6> <h1 class="m-0 main-title" style="padding-left: 60px;">We engineer immune cells to be warriors</h1> <p> </p></div> <h6 style="text-align: center;">Our Gamma 2.0+ platform decreases dosing delays while improving manufacturing economies of scale. It is designed to cost effectively deliver large, complex DNA cargo. And, combined with our cloaking technology evades T and NK cell clearance.</h6> </div> </div> <div class="vc_col-sm-6 "> <div class="wpb_single_image wpb_content_element vc_align_center"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img fetchpriority="high" decoding="async" width="300" height="209" src="https://www.luminarytx.com/wp-content/uploads/PlatformGraphic-300x209.png" class="vc_single_image-img attachment-medium" alt="" title="PlatformGraphic" srcset="https://www.luminarytx.com/wp-content/uploads/PlatformGraphic-300x209.png 300w, https://www.luminarytx.com/wp-content/uploads/PlatformGraphic-1024x714.png 1024w, https://www.luminarytx.com/wp-content/uploads/PlatformGraphic-150x105.png 150w, https://www.luminarytx.com/wp-content/uploads/PlatformGraphic-768x535.png 768w, https://www.luminarytx.com/wp-content/uploads/PlatformGraphic-1536x1070.png 1536w, https://www.luminarytx.com/wp-content/uploads/PlatformGraphic-2048x1427.png 2048w" sizes="(max-width: 300px) 100vw, 300px" /></div> </figure> </div> </div> </div></section><section id="allogeneic-gamma-2+-Platform" class="vc_section"><div id="baff" class="vc_row section-element"> <div class="vc_col-sm-10 "> <div class=" dustrial-stitle-67b2de0ecda1c section-title wow "> <div class="section-thumb"><img decoding="async" src="https://www.luminarytx.com/wp-content/uploads/site-icon.png" alt="title icon"></div> <div class="section-body"> <h6 class="sub-title activeColor">Allogeneic Gamma 2.0+ Platform</h6> <h3 class="m-0 main-title">Allogeneic is the holy grail. We have broken the code.</h3> </div> </div> </div> </div><div class="vc_row section-element"> <div class="vc_col-sm-9 "> <div class="wpb_text_column wpb_content_element "> <h3>Gamma Delta V未1 and V未2 T cells</h3> <p>Patients need “off the shelf” therapies to reduce time for treatment and cure. Allogeneic solutions are being highly sought. Luminary Therapeutic’s promising Gamma 2.0+ platform is currently in nonclinical evaluation. Expansion rates are high; in vivo pilot studies are underway. Results are very promising.</p> <p>Unlike other single subset approaches, our Gamma 2.0+ platform is a two subset (V未1 and V未2) solution creating double the response to cancer killing that is both innate and adaptive.</p> </div> </div> <div class="vc_col-sm-3 "> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="https://www.luminarytx.com/wp-content/uploads/v-delta-t-cells-215x204.jpg" width="215" height="204" alt="v-delta-t-cells" title="v-delta-t-cells" /></div> </figure> </div> </div> </div><div class="vc_row section-element"> <div class="vc_col-sm-9 "> <div class="wpb_text_column wpb_content_element "> <h3>Immune Cloaking Capabilities</h3> <p>Our novel “stealth” immune cloaking approach reduces both MHC class I & II. These stealth cells evade both T and NK cell targeting. This approach does not require nuclease editing (e.g., B2M knockout). These cells are highly functional.</p> </div> </div> <div class="vc_col-sm-3 "> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" width="931" height="495" src="https://www.luminarytx.com/wp-content/uploads/mhc-class-i-and-ii-graphs.jpg" class="vc_single_image-img attachment-full" alt="" title="mhc-class-i-and-ii-graphs" srcset="https://www.luminarytx.com/wp-content/uploads/mhc-class-i-and-ii-graphs.jpg 931w, https://www.luminarytx.com/wp-content/uploads/mhc-class-i-and-ii-graphs-300x160.jpg 300w, https://www.luminarytx.com/wp-content/uploads/mhc-class-i-and-ii-graphs-150x80.jpg 150w, https://www.luminarytx.com/wp-content/uploads/mhc-class-i-and-ii-graphs-768x408.jpg 768w" sizes="(max-width: 931px) 100vw, 931px" /></div> </figure> </div> </div> </div><div class="vc_row section-element"> <div class="vc_col-sm-9 "> <div class="wpb_text_column wpb_content_element "> <h3>Non-Viral Gene Modification Process</h3> <p>Compared to virus-based systems, non-viral gene editing systems have dramatically changed the manufacturing landscape and improved safety. With higher integration rates and faster manufacturing cycles, these systems are rapidly gaining acceptance in the industry. Luminary Therapeutics utilizes a non-viral gene editing system, TcBuster, to manufacture CAR-T cells. TcBuster was developed by B-MoGen, a company formed by the founders of Luminary, and sold to Bio-Techne prior to the creation of Luminary.</p> <p>Benefits of TcBuster’s non-viral gene modification:</p> <ul> <li>Allows for stable integration of large cargo (>10kb)</li> <li>Preferred integration profile compared to retro/lentiviral vectors</li> <li>Generated GMP grade tranposon reagents in <4 months</li> <li>Lower engineering cost than viral vectors by 75-90%</li> </ul> </div> </div> <div class="vc_col-sm-3 "> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img loading="lazy" decoding="async" width="878" height="596" src="https://www.luminarytx.com/wp-content/uploads/tcbuster-platform.jpg" class="vc_single_image-img attachment-full" alt="" title="tcbuster-platform" srcset="https://www.luminarytx.com/wp-content/uploads/tcbuster-platform.jpg 878w, https://www.luminarytx.com/wp-content/uploads/tcbuster-platform-300x204.jpg 300w, https://www.luminarytx.com/wp-content/uploads/tcbuster-platform-150x102.jpg 150w, https://www.luminarytx.com/wp-content/uploads/tcbuster-platform-768x521.jpg 768w" sizes="auto, (max-width: 878px) 100vw, 878px" /></div> </figure> </div> </div> </div></section><div class="vc_row section-element"> <div class="vc_col-sm-12 "> <div class="vc_grid-container-wrapper vc_clearfix vc_grid-animation-fadeIn"> <div class="vc_grid-container vc_clearfix wpb_content_element vc_media_grid" data-initial-loading-animation="fadeIn" data-vc-grid-settings="{"page_id":425,"style":"all","action":"vc_get_vc_grid_data","shortcode_id":"1739164561263-99b905784ac740bf27e52bbf2b3bc264-10","tag":"vc_media_grid"}" data-vc-request="https://www.luminarytx.com/wp-admin/admin-ajax.php" data-vc-post-id="425" data-vc-public-nonce="d4168c5528"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <!-- blog section End --> <!-- start footer section --> <div class="copyright"> <div class="container"> <div class="row"> <div class="col-md-12 text-center"> <div class="copyright-content"> <p> <html> <div style="background: color url('https://www.luminarytx.com/wp-content/uploads/Footer.jpg')"> <p>Copyright 漏 2022 All Rights Reserved by Luminary Therapeutics.</p> <br> <p><img src="https://www.luminarytx.com/wp-content/uploads/cropped-luminary-therapeutics-logo-1.png"</p> </div> </html> </p> </div> </div> </div> </div> </div> <!-- footer section end --> <script> window.RS_MODULES = window.RS_MODULES || {}; 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