Programs - Luminary Therapeutics

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Our work is helping to deliver new standards of care for specific B cell mediated autoimmune diseases." /> <link rel="canonical" href="https://www.luminarytx.com/programs/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Programs - Luminary Therapeutics" /> <meta property="og:description" content="Luminary's solid tumor program is experiencing breakthroughs in solid tumor clearance in in vitro studies using our proprietary split-co-stim dual CAR design. This CSPG4 based dual CAR has application for a variety of solid tumor targets including but not limited to Head and Neck, Ovarian, Colorectal, Liver, Kidney, bile duct, and other cancers. Utilizing our ligand-based BAFF CAR T therapy, Luminary's B cell malignancy program has IND approval for Non-Hodgkin Lymphoma and Multiple Myeloma. We are also pursuing an autoimmune solution for Lupus using the same BAFF CAR T product. Our work is helping to deliver new standards of care for specific B cell mediated autoimmune diseases." /> <meta property="og:url" content="https://www.luminarytx.com/programs/" /> <meta property="og:site_name" content="Luminary Therapeutics" /> <meta property="article:modified_time" content="2023-04-22T01:44:17+00:00" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:label1" content="Est. reading time" /> <meta name="twitter:data1" content="4 minutes" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebPage","@id":"https://www.luminarytx.com/programs/","url":"https://www.luminarytx.com/programs/","name":"Programs - Luminary Therapeutics","isPartOf":{"@id":"https://www.luminarytx.com/#website"},"datePublished":"2023-04-08T23:29:59+00:00","dateModified":"2023-04-22T01:44:17+00:00","description":"Luminary's solid tumor program is experiencing breakthroughs in solid tumor clearance in in vitro studies using our proprietary split-co-stim dual CAR design. 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activebreadcrumbColor">PROGRAMS</h5>  <div class="bread_crumb text-lg-left"> <a href="https://www.luminarytx.com/"> Home<i class="fa fa-angle-right pl-2" aria-hidden="true"></i> </a> <span class="activeColor">PROGRAMS</span> </div>  </div> </div> </div> </div>   <div id="blog" class="blog-page section-space"> <div class="container"> <div class="row"> <div class="col-lg-12 mx-auto col-md-12 col-sm-12 col-12 "> <div id="post-417" class="post-417 page type-page status-publish hentry"> <div class="entry-content"> <section class="vc_section"><div class="vc_row section-element padding-80"> <div class="vc_col-sm-8 "> <div class=" dustrial-stitle-6746753cdc947 section-title wow "> <div class="section-thumb"><img decoding="async" src="https://www.luminarytx.com/wp-content/uploads/site-icon.png" alt="title icon"></div> <div class="section-body"> <h6 class="sub-title activeColor">Versatile Programs</h6> <h3 class="m-0 main-title">Our CARs are versatile having multiple applications for a variety of indications</h3> </div> </div> </div> <div class="vc_col-sm-4 "> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img fetchpriority="high" decoding="async" class="vc_single_image-img " src="https://www.luminarytx.com/wp-content/uploads/scientist-with-test-tube.jpg" width="2048" height="1365" alt="scientist-with-test-tube" title="scientist-with-test-tube" /></div> </figure> </div> </div> </div></section><section id="solid-tumors" class="vc_section"><div class="vc_row section-element vc_custom_1681566652906"> <div class="vc_col-sm-3 vc_col-xs-offset-1 "> <div class="wpb_text_column wpb_content_element "> <p><center></p> <h2>Solid Tumors</h2> <p></center></p> </div> </div> <div class="vc_col-sm-8 "> <div class="wpb_text_column wpb_content_element "> <p><center></p> <h2><span style="color: #ffffff;">Novel co-stimulation mechanism in a dual targeting CAR-T enhances metabolic fitness while addressing antigen escape.</span></h2> <p></center></p> </div> </div> </div></section><section class="vc_section"><div class="vc_row section-element padding-80"> <div class="vc_col-sm-10 "> <div class=" dustrial-stitle-6746753cde383 section-title wow "> <div class="section-thumb"><img decoding="async" src="https://www.luminarytx.com/wp-content/uploads/site-icon.png" alt="title icon"></div> <div class="section-body"> <h6 class="sub-title activeColor">Solid Tumors</h6> <h3 class="m-0 main-title">Split Co-Stim Dual CAR to tackle solid tumors using CSPG4 and CD70</h3> </div> </div> </div> </div><div class="vc_row section-element"> <div class="vc_col-sm-8 "> <div class="wpb_text_column wpb_content_element "> <p>Several Dual CAR’s targeting solid tumors are being investigated in the clinic with the primary endpoint to establish safety and target selection. While admirable, an approach of dual targeting antigens leaves a fundamental challenge unanswered where the approach has likely not sufficiently planned for the most appropriate way to accommodate intracytoplasmic signaling domains of the dual CAR’s. Optimal Co-stimulation is the first critical event to counter immunosuppression within the tumor microenvironment. Luminary has exclusively in-licensed technology from the University of North Carolina where the optimal co-stimulation has been well identified. This technology has demonstrated rapid anti-tumor effects, which are sustained by optimized signaling, effector molecular signature, and metabolic fitness of the CAR-T cells. Furthermore, dual antigen targeting prevents tumor escape when antigen expression in tumor cells is heterogeneous.</p> <p>Luminary intends to establish an allogeneic dual targeting CAR that will consist of CSPG4 and CD70. We are currently demonstrating the functionality of this approach via in vitro testing of multiple solid tumor cancer lines.</p> </div> </div> <div class="vc_col-sm-4 "> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" width="826" height="755" src="https://www.luminarytx.com/wp-content/uploads/luminarytx-split-costim-dual-car-2.jpg" class="vc_single_image-img attachment-full" alt="" title="luminarytx-split-costim-dual-car" srcset="https://www.luminarytx.com/wp-content/uploads/luminarytx-split-costim-dual-car-2.jpg 826w, https://www.luminarytx.com/wp-content/uploads/luminarytx-split-costim-dual-car-2-300x274.jpg 300w, https://www.luminarytx.com/wp-content/uploads/luminarytx-split-costim-dual-car-2-150x137.jpg 150w, https://www.luminarytx.com/wp-content/uploads/luminarytx-split-costim-dual-car-2-768x702.jpg 768w" sizes="(max-width: 826px) 100vw, 826px" /></div> </figure> </div> </div> </div><div class="vc_row section-element"> <div class="vc_col-sm-10 "> <div class=" dustrial-stitle-6746753cdf246 section-title wow "> <div class="section-thumb"><img decoding="async" src="https://www.luminarytx.com/wp-content/uploads/site-icon.png" alt="title icon"></div> <div class="section-body"> <h6 class="sub-title activeColor"></h6> <h3 class="m-0 main-title">Indications</h3> </div> </div> </div> </div><div class="vc_row section-element"> <div class="vc_col-sm-9 "> <div class="wpb_text_column wpb_content_element "> <h3>Head and Neck</h3> <p>Our lead indication is Head and Neck Squamous Cell Carcinoma. We are also evaluating additional indications as potential targets for a Phase I clinical trial.</p> </div> </div> </div></section><section id="b-cell-malignancies" class="vc_section"><div class="vc_row section-element vc_custom_1681566644636"> <div class="vc_col-sm-3 vc_col-xs-offset-1 "> <div class="wpb_text_column wpb_content_element "> <p><center></p> <h2>B cell Malignancies</h2> <p></center></p> </div> </div> <div class="vc_col-sm-8 "> <div class="wpb_text_column wpb_content_element "> <p><center></p> <h2><span style="color: #ffffff;">Luminary’s BAFF CAR<br /> 3 Antigens on a Single CAR<br /> Unprecedented Versatility Across Multiple Cancer Indications<br /> </span></h2> <p></center></p> </div> </div> </div></section><section class="vc_section"><div class="vc_row section-element padding-80"> <div class="vc_col-sm-10 "> <div class=" dustrial-stitle-6746753cdff00 section-title wow "> <div class="section-thumb"><img decoding="async" src="https://www.luminarytx.com/wp-content/uploads/site-icon.png" alt="title icon"></div> <div class="section-body"> <h6 class="sub-title activeColor">B cell Malignancies</h6> <h3 class="m-0 main-title">Versatile BAFF CAR provides promising therapies for B cell disorders</h3> </div> </div> </div> </div><div class="vc_row section-element"> <div class="vc_col-sm-4 "> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" width="1500" height="1370" src="https://www.luminarytx.com/wp-content/uploads/flexibility-with-application-to-many-indications.jpg" class="vc_single_image-img attachment-full" alt="" title="flexibility-with-application-to-many-indications" srcset="https://www.luminarytx.com/wp-content/uploads/flexibility-with-application-to-many-indications.jpg 1500w, https://www.luminarytx.com/wp-content/uploads/flexibility-with-application-to-many-indications-300x274.jpg 300w, https://www.luminarytx.com/wp-content/uploads/flexibility-with-application-to-many-indications-1024x935.jpg 1024w, https://www.luminarytx.com/wp-content/uploads/flexibility-with-application-to-many-indications-150x137.jpg 150w, https://www.luminarytx.com/wp-content/uploads/flexibility-with-application-to-many-indications-768x701.jpg 768w" sizes="(max-width: 1500px) 100vw, 1500px" /></div> </figure> </div> </div> <div class="vc_col-sm-8 "> <div class="wpb_text_column wpb_content_element "> <h3>Flexibility with Application to Many Indications</h3> <p>Luminary’s unique ligand-based CAR targets three antigen receptors. This enables the development of several different cancer and autoimmune therapies without the need to alter the product or the manufacturing process. These receptors (BAFF, BCMA, & TACI) are found on many of the most prevalent hematological cancers. Some are orphan designated indications such as CLL and HCL allowing for quicker regulatory pathways to approval.</p> <p>Luminary is in the final development stages of scaling our the manufacturing platform with the BAFF CAR on our Gamma 2.0+ platform providing a pathway to better patient access for these life-saving therapies!</p> </div> </div> </div><div class="vc_row section-element"> <div class="vc_col-sm-8 "> <div class="wpb_text_column wpb_content_element "> <h3>Solution to Antigen Escape</h3> <p>In the vast universe of CAR-T immunotherapies, there are still challenges to overcome. Our R&D team has recently put forth some eye-opening results. Leading the way is our novel single CAR. Using three receptors, it is designed to overcome a major deficiency of the single antigen CAR – Antigen Escape. This single antigen approach results in failure rates between 25% and 30%, depending on the type of cancer.</p> <p>Our 3-receptor CAR first identifies multiple targets on cancer cells. It then surrounds and attaches to these cells in three ways instead of one, allowing fewer escape routes and increasing overall cancer-killing effectiveness.</p> </div> <div class=" dustrial-stitle-6746753ce0e73 section-title wow "> <div class="section-thumb"><img decoding="async" src="https://www.luminarytx.com/wp-content/uploads/site-icon.png" alt="title icon"></div> <div class="section-body"> <h6 class="sub-title activeColor"></h6> <h3 class="m-0 main-title">Indications</h3> </div> </div> </div> <div class="vc_col-sm-4 "> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img loading="lazy" decoding="async" class="vc_single_image-img " src="https://www.luminarytx.com/wp-content/uploads/solution-to-antigen-escape.jpg" width="732" height="340" alt="solution-to-antigen-escape" title="solution-to-antigen-escape" /></div> </figure> </div> </div> </div><div class="vc_row section-element"> <div class="vc_col-sm-8 "> <div class="wpb_text_column wpb_content_element "> <h3>Non-Hodgkin Lymphoma</h3> <p>Lymphoma is a cancer of the lymphatic system. Lymphoma begins when healthy B cells, T cells, or NK cells in the lymphatic system change and grow out of control, which may form a tumor. Non-Hodgkin lymphoma (NHL) is a term that refers to a group of cancers of the lymphatic system. These cancers can have different symptoms and signs, findings on a physical examination, and treatments.</p> <p>Because lymphatic tissue is found in most parts of the body, NHL can start almost anywhere and can spread, or metastasize, to almost any organ. It often begins in the lymph nodes, liver, spleen, or bone marrow. However, it can also involve the stomach, intestines, skin, thyroid gland, brain, or any other part of the body.</p> <p>Luminary Therapeutics supports the development of our BAFF-CAR-T, a first-of-its-kind CAR-T cell therapy that targets three distinct antigens present on Non-Hodgkin Lymphoma.</p> </div> </div> <div class="vc_col-sm-4 "> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img loading="lazy" decoding="async" width="970" height="570" src="https://www.luminarytx.com/wp-content/uploads/non-hodgkin-lymphoma-graphic.jpg" class="vc_single_image-img attachment-full" alt="" title="non-hodgkin-lymphoma-graphic" srcset="https://www.luminarytx.com/wp-content/uploads/non-hodgkin-lymphoma-graphic.jpg 970w, https://www.luminarytx.com/wp-content/uploads/non-hodgkin-lymphoma-graphic-300x176.jpg 300w, https://www.luminarytx.com/wp-content/uploads/non-hodgkin-lymphoma-graphic-150x88.jpg 150w, https://www.luminarytx.com/wp-content/uploads/non-hodgkin-lymphoma-graphic-768x451.jpg 768w" sizes="(max-width: 970px) 100vw, 970px" /></div> </figure> </div> </div> </div><div class="vc_row section-element"> <div class="vc_col-sm-8 "> <div class="wpb_text_column wpb_content_element "> <h3>Multiple Myeloma</h3> <p>Myeloma is a blood cancer of cells found in the bone marrow specifically the plasma cells. Plasma cells produce antibodies that help the body fight infection. Myeloma begins when healthy plasma cells change and grow out of control. This may result in multiple bone lesions that increase the risk of bone fractures.</p> <p>Luminary Therapeutics supports the development of our BAFF-CAR-T, a first-of-its-kind CAR-T cell therapy that targets three distinct antigens present on multiple myeloma tumors.</p> </div> </div> <div class="vc_col-sm-4 "> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img loading="lazy" decoding="async" width="724" height="426" src="https://www.luminarytx.com/wp-content/uploads/multiple-myeloma-graphic.jpg" class="vc_single_image-img attachment-full" alt="" title="multiple-myeloma-graphic" srcset="https://www.luminarytx.com/wp-content/uploads/multiple-myeloma-graphic.jpg 724w, https://www.luminarytx.com/wp-content/uploads/multiple-myeloma-graphic-300x177.jpg 300w, https://www.luminarytx.com/wp-content/uploads/multiple-myeloma-graphic-150x88.jpg 150w" sizes="(max-width: 724px) 100vw, 724px" /></div> </figure> </div> </div> </div><div class="vc_row section-element"> <div class="vc_col-sm-8 "> <div class="wpb_text_column wpb_content_element "> <h3>Autoimmune – Lupus</h3> <p>Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease with no cure which affects 1.5 million Americans. Autoreactive B cells and the antibodies they produce have emerged as primary drivers of the disease, and therapies targeting B cells have shown promise but require long term treatment and eventually lose efficacy. The BAFF CAR therapy at Luminary identifies and removes autoreactive B cells by directly targeting the B cell activating factor receptors, eliminating the cause of inflammation at the source. The clearance of B cells through the use of the engineered BAFF CAR therapy could be the key to the complete remission of Lupus inflammation in the future.</p> </div> </div> <div class="vc_col-sm-4 "> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img loading="lazy" decoding="async" width="673" height="378" src="https://www.luminarytx.com/wp-content/uploads/lupus-graphic.jpg" class="vc_single_image-img attachment-full" alt="" title="lupus-graphic" srcset="https://www.luminarytx.com/wp-content/uploads/lupus-graphic.jpg 673w, https://www.luminarytx.com/wp-content/uploads/lupus-graphic-300x168.jpg 300w, https://www.luminarytx.com/wp-content/uploads/lupus-graphic-150x84.jpg 150w" sizes="(max-width: 673px) 100vw, 673px" /></div> </figure> </div> </div> </div></section> </div> </div> </div> </div> </div> </div>   <div class="copyright"> <div class="container"> <div class="row"> <div class="col-md-12 text-center"> <div class="copyright-content"> <p> <html> <div style="background: color url('https://www.luminarytx.com/wp-content/uploads/Footer.jpg')"> <p>Copyright © 2022 All Rights Reserved by Luminary Therapeutics.</p> <br> <p><img src="https://www.luminarytx.com/wp-content/uploads/cropped-luminary-therapeutics-logo-1.png"</p> </div> </html> </p> </div> </div> </div> </div> </div>  <script> window.RS_MODULES = window.RS_MODULES || {}; 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