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In Rodents</a></li> <li><a href="https://www.compbio.com/subcutaneous-implants-video/">Subcutaneous Implants + Video</a></li> </ul> </li> </ul> </div> </div> </div> <div id="primary" class="content-area medium-9 columns"> <div class="header-title"> <h1 class="entry-title">Murine Model of Pulmonary Fibrosis and Chronic Inflammation</h1> </div> <main id="main" class="site-main" role="main"> <article id="post-3925" class="post-3925 post type-post status-publish format-standard hentry category-general tag-cannabis-pharmacology tag-efficacy tag-pharmacokinetics tag-tobacco-toxicity tag-toxicity tag-vaping-toxicity"> <div id="breadcrumb"> <div id="crumbs"><span class="crumb"><a href=https://www.compbio.com">Home</a></span> <i class="fa fa-angle-right"></i> <span class="crumb"><a href=https://www.compbio.com/general/">General</a></span> <i class="fa fa-angle-right"></i> <span class="current">Murine Model of Pulmonary Fibrosis and Chronic Inflammation</span></div> </div> <div class="entry-content"> <div class="the-content-contain"> <div class="row builder-row content-row"> <div class="medium-12 columns"> <p> <img class="alignleft size-medium wp-image-3942" src="https://www.compbio.com/images/355_x2-300x226.jpg?v=1713449059" alt="" width="300" height="226" srcset="https://www.compbio.com/images/355_x2-300x226.jpg?v=1713449059 300w, https://www.compbio.com/images/355_x2-768x578.jpg?v=1713449046 768w, https://www.compbio.com/images/355_x2-1024x771.jpg?v=1713449034 1024w, https://www.compbio.com/images/355_x2.jpg?v=1713449015 1360w" sizes="(max-width: 300px) 100vw, 300px"> <img loading="lazy" class="alignleft size-medium wp-image-3943" src="https://www.compbio.com/images/457_x2-300x226.jpg?v=1713449195" alt="" width="300" height="226" srcset="https://www.compbio.com/images/457_x2-300x226.jpg?v=1713449195 300w, https://www.compbio.com/images/457_x2-768x578.jpg?v=1713449187 768w, https://www.compbio.com/images/457_x2-1024x771.jpg?v=1713449178 1024w, https://www.compbio.com/images/457_x2.jpg?v=1713449169 1360w" sizes="(max-width: 300px) 100vw, 300px"> <img loading="lazy" class="alignleft size-medium wp-image-3944" src="https://www.compbio.com/images/457_x4b-300x226.jpg?v=1713449318" alt="" width="300" height="226" srcset="https://www.compbio.com/images/457_x4b-300x226.jpg?v=1713449318 300w, https://www.compbio.com/images/457_x4b-768x578.jpg?v=1713449308 768w, https://www.compbio.com/images/457_x4b-1024x771.jpg?v=1713449299 1024w, https://www.compbio.com/images/457_x4b.jpg?v=1713449292 1360w" sizes="(max-width: 300px) 100vw, 300px"> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p class="p1"><em><span class="s1">Photomicrographs showing low and high magnification of multifocal chronic granulomatous pneumonia with fibrosis and chronic inflammation and hyperplastic bronchial lymphoid tissues throughout lungs of mice with experimental sarcoidosis.</span></em></p> <p> </p> <p class="p1"><span class="s1"><b>Murine Model of </b></span><span class="s2"><b>Sarcoidosis</b></span><span class="s1"><b>: Pulmonary Fibrosis and Chronic Inflammation</b></span></p> <p class="p1"><span class="s1">Murine models of  Sarcoidosis or granulomatous pneumonia, pulmonary fibrosis and hypersensitivity are important for the assessment of novel therapeutics and diagnostics, as well as for the study of disease pathogenesis.  CBI has developed and validated a robust murine model of <i>Propionibacterium acnes-</i>induced hypersensitivity, or granulomatous pneumonia which serves a model for Sarcoidosis. In this model, the repeated intrapulmonary introduction of killed <i>P. acnes</i> induces a robust, uniform and marked inflammatory response in the lung characterized by inflammation, granuloma formation and fibrosis throughout the lung.</span></p> <p>Endpoints may include:</p> <ul> <li>Histopathology</li> <li>Immunohistochemistry and special stains</li> <li>Clinical pathology</li> </ul> <p><strong>Contact us to discuss a scientific study program to fit your Preclinical needs.</strong></p> </div> </div> </div> </div> </article> </main> </div> </div> <div class="call-out"> <h3 class="content-left"><span class="line-one">Have a question</span> <span class="line-two">or need a quote?</span></h3> <svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 100 85" style="enable-background:new 0 0 100 85;" xml:space="preserve"> <style type="text/css"> .st0{fill:#FFFFFF;} </style> <g> <path class="st0" d="M64.3,0.5H16c-8.8,0-16,7.2-16,16V44c0,8.4,6.6,15.4,14.9,16l-3.7,17.4L31.6,60h8.8V43.9 c0-8.7,7.1-15.8,15.8-15.8h24.2V16.5C80.3,7.7,73.1,0.5,64.3,0.5z"/> <path class="st0" d="M89.1,33h-33c-6,0-10.9,4.9-10.9,10.9v18.8c0,6,4.9,10.9,10.9,10.9h22.4l13.9,11.8l-2.5-11.9 c5.7-0.4,10.2-5.1,10.2-10.9V44C100,38,95.1,33,89.1,33z M85.5,49.3c2.2,0,4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1s-4-1.8-4-4.1 C81.5,51.1,83.3,49.3,85.5,49.3z M59.6,57.4c-2.2,0-4-1.8-4-4.1c0-2.2,1.8-4.1,4-4.1c2.2,0,4,1.8,4,4.1 C63.7,55.6,61.9,57.4,59.6,57.4z M68.5,53.4c0-2.2,1.8-4.1,4-4.1s4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1S68.5,55.6,68.5,53.4z"/> </g> </svg> <h3 class="content-right"><span>We can help!</span> <a href="https://www.compbio.com/contact-us/"><span class="cta-btn">Contact us</span></a></h3> </div> </div> </div> <footer id="colophon" class="site-footer row"> <div class="site-info medium-12 columns"> Comparative Biosciences, Inc. · <strong>Phone: 888-994-4879</strong><br> Copyright 2024 Comparative Biosciences, Inc. 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