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In Rodents</a></li> <li><a href="https://www.compbio.com/subcutaneous-implants-video/">Subcutaneous Implants + Video</a></li> </ul> </li> </ul> </div> </div> </div> <div id="primary" class="content-area medium-9 columns"> <div class="header-title"> <h1 class="entry-title">Spinal Trauma In Rodents</h1> </div> <main id="main" class="site-main" role="main"> <article id="post-5163" class="post-5163 post type-post status-publish format-standard hentry category-general"> <div id="breadcrumb"> <div id="crumbs"><span class="crumb"><a href="https://www.compbio.com/">Home</a></span> <i class="fa fa-angle-right"></i> <span class="crumb"><a href="https://www.compbio.com/general/">General</a></span> <i class="fa fa-angle-right"></i> <span class="current">Spinal Trauma In Rodents</span></div> </div> <div class="entry-content"> <div class="the-content-contain"> <div class="row builder-row content-row"> <div class="medium-12 columns"> <h3><img class="wp-image-5169 alignleft" style="font-size: 16px; font-weight: normal;" src="https://www.compbio.com/images/CBI-website-spinal-trauma.jpg?v=1713386295" alt="" width="1297" height="677" srcset="https://www.compbio.com/images/CBI-website-spinal-trauma.jpg?v=1713386295 1700w, https://www.compbio.com/images/CBI-website-spinal-trauma-300x157.jpg?v=1713386291 300w, https://www.compbio.com/images/CBI-website-spinal-trauma-1024x534.jpg?v=1713386287 1024w, https://www.compbio.com/images/CBI-website-spinal-trauma-768x401.jpg?v=1713386282 768w, https://www.compbio.com/images/CBI-website-spinal-trauma-1536x801.jpg?v=1713386277 1536w" sizes="(max-width: 1297px) 100vw, 1297px"></h3> <h3></h3> <h3><strong>Spinal Trauma in Rodent Studies at CBI</strong></h3> <p>A long-standing goal of spinal cord injury research is to develop effective spinal cord repair strategies for the clinic. Here at CBI, rat models of spinal cord injury provide an important mammalian model in which to evaluate treatment strategies and to understand the pathological basis of spinal cord injuries. These models have facilitated the development of robust tests for assessing the recovery of locomotor and sensory functions. Rat models have also allowed us to understand how neuronal circuitry changes following spinal cord injury and how recovery could be promoted by enhancing spontaneous regenerative mechanisms and by counteracting intrinsic inhibitory factors. Rat studies have also revealed possible routes to rescuing circuitry and cells in the acute stage of injury. Spatiotemporal and functional studies in these models highlight the therapeutic potential of manipulating inflammation, scarring and myelination. In addition, potential replacement therapies for spinal cord injury, including grafts and bridges, stem primarily from rat studies. Here, we discuss advantages and disadvantages of rat experimental spinal cord injury models and summarize knowledge gained from these models. Our studies also show an emerging understanding of different forms of injury, their pathology and degree of recovery has inspired numerous treatment strategies, some of which have led to preclinical trials.</p> <p> </p> <div id="_VA4jYP-PJo--0PEPiIipoA852" class="mWyH1d hide-focus-ring FXMOpb" tabindex="0" role="button" aria-controls="_VA4jYP-PJo--0PEPiIipoA851" aria-expanded="true"> <div id="_VA4jYP-PJo--0PEPiIipoA862" class="mWyH1d hide-focus-ring FXMOpb" tabindex="0" role="button" aria-controls="_VA4jYP-PJo--0PEPiIipoA861" aria-expanded="true"> <h3 class="hide-focus-ring cbphWd" data-kt="Ki_DnczvudS1qdIB-6_a0pKwxtIJ8oH2_b_uhYmcAbL8w4DCuO3mccTQle7WsJTjHg" data-hveid="CBcQEA" data-ved="2ahUKEwj_iavL7t3uAhUPHzQIHQhECvQQuk4oAHoECBcQEA">• What is Spine Trauma?</h3> </div> <div id="_VA4jYP-PJo--0PEPiIipoA861" class="gy6Qzb oNjtBb V1sL5c" aria-labelledby="_VA4jYP-PJo--0PEPiIipoA862"> <div> <div id="_VA4jYP-PJo--0PEPiIipoA863" class="y8URue" data-hveid="CBcQEQ" data-ved="2ahUKEwj_iavL7t3uAhUPHzQIHQhECvQQu04oAXoECBcQEQ"> <div class="mod" data-md="61"> <div class="LGOjhe" role="heading" data-attrid="wa:/description" aria-level="3" data-hveid="CBUQAA"><span class="ILfuVd NA6bn"><span class="hgKElc"><b>Spinal trauma</b> is damage to the spinal cord caused by an injury. The spinal cord contains nerves that carry messages between the brain and the body, so damage can cause permanent changes in bodily functions.</span></span></div> </div> </div> <div role="heading" data-attrid="wa:/description" aria-level="3" data-hveid="CBUQAA"></div> </div> </div> <h3 data-kt="Ki_rm6e_p4yEzZwBw6aauPuzurJ2torDobW1-sINlsu_7PG6y9mfAdeCl7zeh42DFw" data-hveid="CBcQCA" data-ved="2ahUKEwj_iavL7t3uAhUPHzQIHQhECvQQuk4oAHoECBcQCA"></h3> <h3 data-kt="Ki_rm6e_p4yEzZwBw6aauPuzurJ2torDobW1-sINlsu_7PG6y9mfAdeCl7zeh42DFw" data-hveid="CBcQCA" data-ved="2ahUKEwj_iavL7t3uAhUPHzQIHQhECvQQuk4oAHoECBcQCA"></h3> <h3 class="hide-focus-ring cbphWd" data-kt="Ki_rm6e_p4yEzZwBw6aauPuzurJ2torDobW1-sINlsu_7PG6y9mfAdeCl7zeh42DFw" data-hveid="CBcQCA" data-ved="2ahUKEwj_iavL7t3uAhUPHzQIHQhECvQQuk4oAHoECBcQCA">• What has been done with Rats and Spinal Cords?</h3> </div> <div id="_VA4jYP-PJo--0PEPiIipoA851" class="gy6Qzb oNjtBb V1sL5c" aria-labelledby="_VA4jYP-PJo--0PEPiIipoA852"> <div> <div id="_VA4jYP-PJo--0PEPiIipoA853" class="y8URue" data-hveid="CBcQCQ" data-ved="2ahUKEwj_iavL7t3uAhUPHzQIHQhECvQQu04oAXoECBcQCQ"> <div class="mod" data-md="61"> <div class="LGOjhe" role="heading" data-attrid="wa:/description" aria-level="3" data-hveid="CBQQAA"><span class="ILfuVd NA6bn"><span class="hgKElc"><b>Rats</b> whose spinal cords had been severed can regain movement by reorganizing brain circuits associated with muscle control. The rats partially recovered the ability to move their hind limbs unassisted, and brain circuits associated with activation of the rats’ trunk muscles were found to be reorganized.</span></span></div> </div> <div role="heading" data-attrid="wa:/description" aria-level="3" data-hveid="CBQQAA"> <div id="_ChAjYLiNM4zO0PEP16elyAE14" class="mWyH1d hide-focus-ring FXMOpb" tabindex="0" role="button" aria-controls="_ChAjYLiNM4zO0PEP16elyAE13" aria-expanded="true"> <h3 class="hide-focus-ring cbphWd" data-kt="Ki--ssDhy4rf7p8B35W3v62P_aBfv9b1w4fMpoo0mNy50eW5g7p_4Py11eqpweLIAQ" data-hveid="CAcQAQ" data-ved="2ahUKEwi4uqWc8N3uAhUMJzQIHddTCRkQuk4oAHoECAcQAQ">• Can Spinal Nerve Damage be Repaired?</h3> </div> <div id="_ChAjYLiNM4zO0PEP16elyAE13" class="gy6Qzb oNjtBb V1sL5c" aria-labelledby="_ChAjYLiNM4zO0PEP16elyAE14"> <div> <div class="y8URue" data-hveid="CAcQAg" data-ved="2ahUKEwi4uqWc8N3uAhUMJzQIHddTCRkQu04oAXoECAcQAg"> <div class="mod" data-md="61"> <div class="LGOjhe" role="heading" data-attrid="wa:/description" aria-level="3" data-hveid="CAQQAA"><span class="ILfuVd NA6bn"><span class="hgKElc">The <b>spinal cord</b> rarely repairs itself when <b>damaged</b>, but ways of encouraging <b>nerves</b> to regrow are on the horizon.</span></span></div> </div> </div> </div> </div> </div> </div> </div> </div> <h3 class="hide-focus-ring cbphWd" style="text-align: left;" data-kt="Ki--ssDhy4rf7p8B35W3v62P_aBfv9b1w4fMpoo0mNy50eW5g7p_4Py11eqpweLIAQ" data-hveid="CAcQAQ" data-ved="2ahUKEwi4uqWc8N3uAhUMJzQIHddTCRkQuk4oAHoECAcQAQ">                                           Our Surgical Options.</h3> <p style="text-align: left;">At CBI, one of our surgical treatment options for the most common form of chronic SCI (at the stage of formed structural defects) requiring surgery is to create favorable conditions for axonal growth by providing “free” space in the structural defect area via the removal of mechanical barriers (scars) by their excision to healthy tissue. This idea has served as the basis for a number of studies on the surgical creation of a structural defect of the spinal cord in rats by complete transection of the cord with a scalpel and partial resection with microsurgical scissors</p> <p> </p> <p><strong>Contact Comparative Biosciences, Inc. to discuss a scientific study program for Spinal Trauma Studies and Services.</strong></p> <p><strong>Comparative Biosciences, Inc.    ·    Phone: 408.738.9260</strong></p> <p> </p> <p>– CUSTOM INTRAVESICULAR TOXICOLOGY, PHARMACOKINETICS AND EFFICACY STUDIES UPON REQUEST –</p> </div> </div> </div> </div> </article> </main> </div> </div> <div class="call-out"> <h3 class="content-left"><span class="line-one">Have a question</span> <span class="line-two">or need a quote?</span></h3> <svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 100 85" style="enable-background:new 0 0 100 85;" xml:space="preserve"> <style type="text/css"> .st0{fill:#FFFFFF;} </style> <g> <path class="st0" d="M64.3,0.5H16c-8.8,0-16,7.2-16,16V44c0,8.4,6.6,15.4,14.9,16l-3.7,17.4L31.6,60h8.8V43.9 c0-8.7,7.1-15.8,15.8-15.8h24.2V16.5C80.3,7.7,73.1,0.5,64.3,0.5z"/> <path class="st0" d="M89.1,33h-33c-6,0-10.9,4.9-10.9,10.9v18.8c0,6,4.9,10.9,10.9,10.9h22.4l13.9,11.8l-2.5-11.9 c5.7-0.4,10.2-5.1,10.2-10.9V44C100,38,95.1,33,89.1,33z M85.5,49.3c2.2,0,4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1s-4-1.8-4-4.1 C81.5,51.1,83.3,49.3,85.5,49.3z M59.6,57.4c-2.2,0-4-1.8-4-4.1c0-2.2,1.8-4.1,4-4.1c2.2,0,4,1.8,4,4.1 C63.7,55.6,61.9,57.4,59.6,57.4z M68.5,53.4c0-2.2,1.8-4.1,4-4.1s4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1S68.5,55.6,68.5,53.4z"/> </g> </svg> <h3 class="content-right"><span>We can help!</span> <a href="https://www.compbio.com/contact-us/"><span class="cta-btn">Contact us</span></a></h3> </div> </div> </div> <footer id="colophon" class="site-footer row"> <div class="site-info medium-12 columns"> Comparative Biosciences, Inc. · <strong>Phone: 888-994-4879</strong><br> Copyright 2024 Comparative Biosciences, Inc. 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