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class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="Maël Montévil" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/28744524/11941342/13306232/s200_ma_l.mont_vil.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Maël Montévil</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://ens.academia.edu/">École Normale Supérieure</a>, <a class="u-tcGrayDarker" href="https://ens.academia.edu/Departments/R%C3%A9publique_des_savoirs_USR_3608/Documents">République des savoirs USR 3608</a>, <span class="u-tcGrayDarker">Faculty Member</span></div><div><a class="u-tcGrayDarker" href="https://cnrs.academia.edu/">Centre National de la Recherche Scientifique / French National Centre for Scientific Research</a>, <a class="u-tcGrayDarker" href="https://cnrs.academia.edu/Departments/R%C3%A9publique_des_Savoirs/Documents">République des Savoirs</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Maël" data-follow-user-id="28744524" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="28744524"><span class="material-symbols-outlined" style="font-size: 20px" 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working at the crossroad of experimental biology, mathematics, and philosophy of science. His work focuses on the theoretical foundations of biology, and the role that mathematics can play in this field.  He also applies the general frameworks that he develops to current issues such as endocrine disruptors and more generally the antropocene.<br />https://montevil.org<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span><a class="ri-more-link js-profile-ri-list-card" data-click-track="profile-user-info-primary-research-interest" data-has-card-for-ri-list="28744524">View All (48)</a></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="28744524" href="https://www.academia.edu/Documents/in/Evolutionary_Biology"><div id="js-react-on-rails-context" style="display:none" 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class="profile--tab_heading_container">Papers by Maël Montévil</h3></div><div class="js-work-strip profile--work_container" data-work-id="70740145"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70740145/Conceptual_and_theoretical_specifications_for_accuracy_in_medicine_"><img alt="Research paper thumbnail of Conceptual and theoretical specifications for accuracy in medicine *" class="work-thumbnail" src="https://attachments.academia-assets.com/80362350/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70740145/Conceptual_and_theoretical_specifications_for_accuracy_in_medicine_">Conceptual and theoretical specifications for accuracy in medicine *</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Technological developments in genomics and other -omics originated the idea that precise measurem...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Technological developments in genomics and other -omics originated the idea that precise measurements would lead to better therapeutic strategies. However, precision does not entail accuracy. Scientific accuracy requires a theoretical framework to understand the meaning of measurements, the nature of causal relationships, and potential intrinsic limitations of knowledge. For example, a precise measurement of initial positions in classical mechanics is useless without initial velocities; it is not an accurate measurement of the initial condition. Conceptual and theoretical accuracy is required for precision to lead to the progress of knowledge and rationality in action. In the search for accuracy in medicine, we first outline our results on a theory of organisms. Biology is distinct from physics and requires a specific epistemology. In particular, we develop the meaning of biological measurements and emphasize that variability and historicity are fundamental notions. However, medicin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b548a1942b3b257976fa151da317f9fc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80362350,"asset_id":70740145,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80362350/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740145"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740145"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740145; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740145]").text(description); $(".js-view-count[data-work-id=70740145]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740145; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740145']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740145, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b548a1942b3b257976fa151da317f9fc" } } $('.js-work-strip[data-work-id=70740145]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740145,"title":"Conceptual and theoretical specifications for accuracy in medicine *","translated_title":"","metadata":{"abstract":"Technological developments in genomics and other -omics originated the idea that precise measurements would lead to better therapeutic strategies. 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For toft , the ‘cancer cell’ is a phlogiston, smt is an old paradigm which ought to be replaced. Recently two critics have argued that toft and smt , despite their apparent strong incompatibilities, are actually compatible. Here we review their arguments. We show that these arguments are based on interpretation mistakes that become understandable once one grants that criticizing a paradigm from the point of view of another, in which words do not have the same signification, bears the risk of strong misunderstandings. These misunderstandings, in our experience, are common. 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Biological identity can be defined either diachronically by looking at the past of individual organisms, or synchronically by referring to the relational description of their organization and interaction with the environment. A possible stance would consist in taking them as alternative and competing conceptions. In this paper, we put forward a different position, according to which there is a fundamental complementarity between them. The identity of biological objects is hybrid, insofar as it lies at the crossroad between the diachronic and synchronic conceptions. In addition, we submit that biological identity is also bounded, because the compliance with specific criteria tends to vanish as time passes, especially across generations. We spell out the resulting conceptual framework, and outline a formal representation of such hybrid and bounded identity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740143"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740143"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740143; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740143]").text(description); $(".js-view-count[data-work-id=70740143]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740143; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740143']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740143, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=70740143]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740143,"title":"Biological identity at the crossroad between historical and relational conceptions","translated_title":"","metadata":{"abstract":"We address1 the identity of biological organisms by examining two distinct conceptions at work in theoretical and empirical work. 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We spell out the resulting conceptual framework, and outline a formal representation of such hybrid and bounded identity.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}}},"translated_abstract":"We address1 the identity of biological organisms by examining two distinct conceptions at work in theoretical and empirical work. Biological identity can be defined either diachronically by looking at the past of individual organisms, or synchronically by referring to the relational description of their organization and interaction with the environment. A possible stance would consist in taking them as alternative and competing conceptions. In this paper, we put forward a different position, according to which there is a fundamental complementarity between them. The identity of biological objects is hybrid, insofar as it lies at the crossroad between the diachronic and synchronic conceptions. In addition, we submit that biological identity is also bounded, because the compliance with specific criteria tends to vanish as time passes, especially across generations. We spell out the resulting conceptual framework, and outline a formal representation of such hybrid and bounded identity.","internal_url":"https://www.academia.edu/70740143/Biological_identity_at_the_crossroad_between_historical_and_relational_conceptions","translated_internal_url":"","created_at":"2022-02-06T12:20:10.296-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Biological_identity_at_the_crossroad_between_historical_and_relational_conceptions","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[],"research_interests":[],"urls":[{"id":17384687,"url":"https://montevil.theobio.org/en/system/files/articlepdf/identity-web.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70740142"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70740142/SAMA_A_Method_for_3_D_Morphological_Analysis"><img alt="Research paper thumbnail of SAMA : A Method for 3 D Morphological Analysis" class="work-thumbnail" src="https://attachments.academia-assets.com/80362344/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70740142/SAMA_A_Method_for_3_D_Morphological_Analysis">SAMA : A Method for 3 D Morphological Analysis</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Three-dimensional (3D) culture models are critical tools for understanding tissue morphogenesis. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Three-dimensional (3D) culture models are critical tools for understanding tissue morphogenesis. A key requirement for their analysis is the ability to reconstruct the tissue into computational models that allow quantitative evaluation of the formed structures. Here, we present Software for Automated Morphological Analysis (SAMA), a method by which epithelial structures grown in 3D cultures can be imaged, reconstructed and analyzed with minimum human intervention. SAMA allows quantitative analysis of key features of epithelial morphogenesis such as ductal elongation, branching and lumen formation that distinguish different hormonal treatments. SAMA is a user-friendly set of customized macros operated via FIJI (<a href="http://fiji.sc/Fiji" rel="nofollow">http://fiji.sc/Fiji</a>), an open-source image analysis platform in combination with a set of functions in R (<a href="http://www.r-project.org/" rel="nofollow">http://www.r-project.org/</a>), an open-source program for statistical analysis. SAMA enables a rapid, exhaustive and quantitative 3D analysis of the shape of a population of ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e2f97da5c18164b2c32dfeb62d5ef6cc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80362344,"asset_id":70740142,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80362344/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740142"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740142"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740142; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740142]").text(description); $(".js-view-count[data-work-id=70740142]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740142; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740142']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740142, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e2f97da5c18164b2c32dfeb62d5ef6cc" } } $('.js-work-strip[data-work-id=70740142]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740142,"title":"SAMA : A Method for 3 D Morphological Analysis","translated_title":"","metadata":{"abstract":"Three-dimensional (3D) culture models are critical tools for understanding tissue morphogenesis. 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On t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Some authors assert that the analysis of huge databases could replace the scientific method. On the contrary, we argue that the best way to make these new technologies bear fruits is to frame them with theories concerning the phenomena of interest. Such theories hint to the observable that should be taken into account and the mathematical structures that may link them. In biology, we argue that the community urgently needs an overarching theory of organisms that would provide a precise framework to understand lifecycles. Among other benefits, such a theory should make explicit what we can and cannot predict in principle.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="16ccd3c6d106a77e4a85b9b7f2f354da" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80362343,"asset_id":70740139,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80362343/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740139"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740139"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740139; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740139]").text(description); $(".js-view-count[data-work-id=70740139]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740139; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740139']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740139, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "16ccd3c6d106a77e4a85b9b7f2f354da" } } $('.js-work-strip[data-work-id=70740139]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740139,"title":"Big Data and Biological Knowledge 12","translated_title":"","metadata":{"abstract":"Some authors assert that the analysis of huge databases could replace the scientific method. On the contrary, we argue that the best way to make these new technologies bear fruits is to frame them with theories concerning the phenomena of interest. Such theories hint to the observable that should be taken into account and the mathematical structures that may link them. In biology, we argue that the community urgently needs an overarching theory of organisms that would provide a precise framework to understand lifecycles. Among other benefits, such a theory should make explicit what we can and cannot predict in principle.","publication_date":{"day":null,"month":null,"year":2018,"errors":{}}},"translated_abstract":"Some authors assert that the analysis of huge databases could replace the scientific method. On the contrary, we argue that the best way to make these new technologies bear fruits is to frame them with theories concerning the phenomena of interest. Such theories hint to the observable that should be taken into account and the mathematical structures that may link them. In biology, we argue that the community urgently needs an overarching theory of organisms that would provide a precise framework to understand lifecycles. 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Ici, nous présentons et articulons brièvement les trois principes proposés récemment pour une théorie des organismes, à savoir : l&#39;état par défaut, prolifération avec variation et motilité, le principe de variation et le principe d&#39;organisation. Ces principes modifient profondément les observables biologiques et leur nature théorique par rapport aux cadres des théories physiques. Ce changement radical ouvre la possibilité d&#39;ancrer la modélisation mathématique à des principes proprement biologiques.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="91c6fad44f190010ef50600260b5cad4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80362341,"asset_id":70740138,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80362341/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740138"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740138"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740138; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740138]").text(description); $(".js-view-count[data-work-id=70740138]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740138; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740138']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740138, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "91c6fad44f190010ef50600260b5cad4" } } $('.js-work-strip[data-work-id=70740138]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740138,"title":"Du siècle du gène à celui de l’organisme : introduction à de nouvelles perspectives théoriques","translated_title":"","metadata":{"abstract":"Les organismes, qu\u0026#39;ils soient uni ou multi-cellulaires, sont des agents capables de créer leurs propres normes ; ils articulent continuellement leur capacité à créer de la nouveauté et de la stabilité, c\u0026#39;est-à-dire qu\u0026#39;ils combinent plasticité et robustesse. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70740137"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70740137/From_the_Century_of_the_Gene_to_that_of_the_Organism_Introduction_to_New_Theoretical_Perspectives"><img alt="Research paper thumbnail of From the Century of the Gene to that of the Organism: Introduction to New Theoretical Perspectives" class="work-thumbnail" src="https://attachments.academia-assets.com/80362339/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70740137/From_the_Century_of_the_Gene_to_that_of_the_Organism_Introduction_to_New_Theoretical_Perspectives">From the Century of the Gene to that of the Organism: Introduction to New Theoretical Perspectives</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Organisms, whether uni or multi-cellular, are agents that make their own norms; they continually ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Organisms, whether uni or multi-cellular, are agents that make their own norms; they continually express their ability to generate novelty and stability, that is to say they combine plasticity and robustness. Here, we briefly present and describe the three main principles that our group proposes for a theory of organisms, namely: the default state, proliferation with variation and motility, the principle of variation and the principle of organization. These principles profoundly modify biological observables and their theoretical nature compared to the situation in physical theories. This radical change opens up the possibility of anchoring mathematical modeling to biological principles.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="88b6b0d187150212db87d58153f7b5a0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80362339,"asset_id":70740137,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80362339/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740137"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740137"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740137; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740137]").text(description); $(".js-view-count[data-work-id=70740137]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740137; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740137']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740137, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "88b6b0d187150212db87d58153f7b5a0" } } $('.js-work-strip[data-work-id=70740137]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740137,"title":"From the Century of the Gene to that of the Organism: Introduction to New Theoretical Perspectives","translated_title":"","metadata":{"abstract":"Organisms, whether uni or multi-cellular, are agents that make their own norms; they continually express their ability to generate novelty and stability, that is to say they combine plasticity and robustness. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70740134"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70740134/Temps_biologique_et_transitions_critiques_%C3%A9tendues_Vers_une_objectivation_de_l_%C3%A9tat_vivant_de_la_mati%C3%A8re"><img alt="Research paper thumbnail of Temps biologique et transitions critiques étendues : Vers une objectivation de l’état vivant de la matière" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70740134/Temps_biologique_et_transitions_critiques_%C3%A9tendues_Vers_une_objectivation_de_l_%C3%A9tat_vivant_de_la_mati%C3%A8re">Temps biologique et transitions critiques étendues : Vers une objectivation de l’état vivant de la matière</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This work takes place in the context of a theoretical approach in biology which uses the examples...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This work takes place in the context of a theoretical approach in biology which uses the examples of objectivation in physical theories without reducing biological phenomenalities to them. We begin by investigating the empirical biological scaling relationships found in the literature (allometric relationships, fractals, …), including their variability. We will then consider two different aspects of biological time. First, we will develop the notions of protension and retention as an account of local organization of biological time. Then we consider a supplementary temporal dimension to accommodate proper biological rhythms. Since the notion of symmetry plays a foundational role in physics, we investigate its possible role in biology. In relation with the notion of extended critical transitions, we propose the hypothesis that organisms and evolution can be understood as characterized by ubiquitous symmetry changes. This transform the status of biological objects, provides an approac...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740134"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740134"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740134; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740134]").text(description); $(".js-view-count[data-work-id=70740134]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740134; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740134']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740134, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=70740134]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740134,"title":"Temps biologique et transitions critiques étendues : Vers une objectivation de l’état vivant de la matière","translated_title":"","metadata":{"abstract":"This work takes place in the context of a theoretical approach in biology which uses the examples of objectivation in physical theories without reducing biological phenomenalities to them. 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In relation with the notion of extended critical transitions, we propose the hypothesis that organisms and evolution can be understood as characterized by ubiquitous symmetry changes. This transform the status of biological objects, provides an approac...","internal_url":"https://www.academia.edu/70740134/Temps_biologique_et_transitions_critiques_%C3%A9tendues_Vers_une_objectivation_de_l_%C3%A9tat_vivant_de_la_mati%C3%A8re","translated_internal_url":"","created_at":"2022-02-06T12:20:09.219-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Temps_biologique_et_transitions_critiques_étendues_Vers_une_objectivation_de_l_état_vivant_de_la_matière","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70740104"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70740104/Randomness_increases_biological_organization_a_mathematical_understanding_of_Goulds_critique_of_evolutionary_progress_1"><img alt="Research paper thumbnail of Randomness increases biological organization: a mathematical understanding of Gould's critique of evolutionary progress 1" class="work-thumbnail" src="https://attachments.academia-assets.com/80362306/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70740104/Randomness_increases_biological_organization_a_mathematical_understanding_of_Goulds_critique_of_evolutionary_progress_1">Randomness increases biological organization: a mathematical understanding of Gould's critique of evolutionary progress 1</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this text, we informally expose the mathematical analysis in [BL09] of Gould’s ideas on the in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this text, we informally expose the mathematical analysis in [BL09] of Gould’s ideas on the increase of “complexity” along biological evolution as a result of random paths. We also revisit some related theoretical investigations on randomness (contingency) and symmetry breakings in biology, following [LM12]. Gould made several fundamental observations on how phenotypic complexity increases on average, in a random evolution, without a bias towards an increase. Technically, we understand complexity as anti-entropy, a proper biological observable. Its increase, by symmetry changes, involves a strong form of randomness. In more usual biological terms, an increase of complexity involves new elements of biological organization and the latter are “contingent” because they are not determined by the current state of the life dynamics. 1 Randomness and Complexification in Evolution. Available energy consumption and transformation, thus entropy production, are the unavoidable physical proce...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="91b3a4f207679516c34da6a2572bbc20" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80362306,"asset_id":70740104,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80362306/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740104"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740104"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740104; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740104]").text(description); $(".js-view-count[data-work-id=70740104]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740104; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740104']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740104, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "91b3a4f207679516c34da6a2572bbc20" } } $('.js-work-strip[data-work-id=70740104]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740104,"title":"Randomness increases biological organization: a mathematical understanding of Gould's critique of evolutionary progress 1","translated_title":"","metadata":{"abstract":"In this text, we informally expose the mathematical analysis in [BL09] of Gould’s ideas on the increase of “complexity” along biological evolution as a result of random paths. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="64814573"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/64814573/Bifurquer_Il_ny_a_pas_dalternative"><img alt="Research paper thumbnail of Bifurquer: Il n'y a pas d'alternative" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/64814573/Bifurquer_Il_ny_a_pas_dalternative">Bifurquer: Il n'y a pas d'alternative</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ce livre – remarquablement documente tant dans les idees et les propositions que dans les pratiqu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ce livre – remarquablement documente tant dans les idees et les propositions que dans les pratiques qui essaiment deja dans certaines villes ou pays – dessine le monde tel qu’il devrait etre pour repondre aux grandes crises sanitaires, climatiques, sociales ou psychiques. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48948563"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48948563/Montevil_Entropies_Anthropocene"><img alt="Research paper thumbnail of Montevil Entropies Anthropocene" class="work-thumbnail" src="https://attachments.academia-assets.com/67346304/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48948563/Montevil_Entropies_Anthropocene">Montevil Entropies Anthropocene</a></div><div class="wp-workCard_item"><span>Ai And society</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Anthropocene crisis is frequently described as the rarefaction of resources or resources per ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Anthropocene crisis is frequently described as the rarefaction of resources or resources per capita. However, both energy and minerals correspond to fundamentally conserved quantities from the perspective of physics. A specific concept is required to understand the rarefaction of available resources. This concept, entropy, pertains to energy and matter configurations and not just to their sheer amount.<br />However, the physics concept of entropy is insufficient to understand biological and social organizations. Biological phenomena display both historicity and systemic properties. A biological organization, the ability of a specific living being to last over time, results from history, expresses itself by systemic properties, and may require generating novelties The concept of anti-entropy stems from the combination of these features. We propose that Anthropocene changes disrupt biological organizations by randomizing them, that is, decreasing anti-entropy. Moreover, second-order disruptions correspond to the decline of the ability to produce functional novelties, that is, to produce anti-entropy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="edb419bb5938366fa77cd17cd0ec6d61" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67346304,"asset_id":48948563,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67346304/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48948563"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48948563"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48948563; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48948563]").text(description); $(".js-view-count[data-work-id=48948563]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48948563; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48948563']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 48948563, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "edb419bb5938366fa77cd17cd0ec6d61" } } $('.js-work-strip[data-work-id=48948563]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48948563,"title":"Montevil Entropies Anthropocene","translated_title":"","metadata":{"doi":"10.1007/s00146-021-01221-0","abstract":"The Anthropocene crisis is frequently described as the rarefaction of resources or resources per capita. 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Moreover, second-order disruptions correspond to the decline of the ability to produce functional novelties, that is, to produce anti-entropy.","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Ai And society"},"translated_abstract":"The Anthropocene crisis is frequently described as the rarefaction of resources or resources per capita. However, both energy and minerals correspond to fundamentally conserved quantities from the perspective of physics. A specific concept is required to understand the rarefaction of available resources. This concept, entropy, pertains to energy and matter configurations and not just to their sheer amount.\nHowever, the physics concept of entropy is insufficient to understand biological and social organizations. Biological phenomena display both historicity and systemic properties. A biological organization, the ability of a specific living being to last over time, results from history, expresses itself by systemic properties, and may require generating novelties The concept of anti-entropy stems from the combination of these features. We propose that Anthropocene changes disrupt biological organizations by randomizing them, that is, decreasing anti-entropy. Moreover, second-order disruptions correspond to the decline of the ability to produce functional novelties, that is, to produce anti-entropy.","internal_url":"https://www.academia.edu/48948563/Montevil_Entropies_Anthropocene","translated_internal_url":"","created_at":"2021-05-17T05:53:16.124-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":67346304,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67346304/thumbnails/1.jpg","file_name":"2021_Montevil_Entropies_Anthropocene.pdf","download_url":"https://www.academia.edu/attachments/67346304/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Montevil_Entropies_Anthropocene.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67346304/2021_Montevil_Entropies_Anthropocene-libre.pdf?1621257434=\u0026response-content-disposition=attachment%3B+filename%3DMontevil_Entropies_Anthropocene.pdf\u0026Expires=1732221638\u0026Signature=QCiMW7g9zfsnEfFCLJc1-ZPXDeB-2XTgp1Ysi2aW60UE7nn-HhKdjvJWM1zEsp1yPveATAJ7IDnmw2gjGuY2bpWpggHmG1fFa4xHWD1BhjqilQ6O4gaXL9j8MXztdil5GV0FO2xHyIp1IIzjeb66PuKmqajYfDNC7fu3x6oS~Z4gNW-~DMBf0z9IAHOIZeBNV7FtLbvGBdIsK6trjwRLeP129pbIMQMAkn6OUHhrUKAVmY2jvFYjlZ9F5bACQq3LVXvBmCYWVjDa1dCN8QiK6kqwaTP8mFRsK8weytJsmpJv0cGY9JTfhJLgwtWePbuSPcuYyHk74opYF8bkNkYBww__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Montevil_Entropies_Anthropocene","translated_slug":"","page_count":32,"language":"en","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[{"id":67346304,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67346304/thumbnails/1.jpg","file_name":"2021_Montevil_Entropies_Anthropocene.pdf","download_url":"https://www.academia.edu/attachments/67346304/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Montevil_Entropies_Anthropocene.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67346304/2021_Montevil_Entropies_Anthropocene-libre.pdf?1621257434=\u0026response-content-disposition=attachment%3B+filename%3DMontevil_Entropies_Anthropocene.pdf\u0026Expires=1732221638\u0026Signature=QCiMW7g9zfsnEfFCLJc1-ZPXDeB-2XTgp1Ysi2aW60UE7nn-HhKdjvJWM1zEsp1yPveATAJ7IDnmw2gjGuY2bpWpggHmG1fFa4xHWD1BhjqilQ6O4gaXL9j8MXztdil5GV0FO2xHyIp1IIzjeb66PuKmqajYfDNC7fu3x6oS~Z4gNW-~DMBf0z9IAHOIZeBNV7FtLbvGBdIsK6trjwRLeP129pbIMQMAkn6OUHhrUKAVmY2jvFYjlZ9F5bACQq3LVXvBmCYWVjDa1dCN8QiK6kqwaTP8mFRsK8weytJsmpJv0cGY9JTfhJLgwtWePbuSPcuYyHk74opYF8bkNkYBww__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":2008,"name":"Machine Learning","url":"https://www.academia.edu/Documents/in/Machine_Learning"},{"id":18612,"name":"Pollination ecology","url":"https://www.academia.edu/Documents/in/Pollination_ecology"},{"id":22142,"name":"Ecosystem health","url":"https://www.academia.edu/Documents/in/Ecosystem_health"},{"id":23032,"name":"Tribology","url":"https://www.academia.edu/Documents/in/Tribology"},{"id":30347,"name":"Translation","url":"https://www.academia.edu/Documents/in/Translation"},{"id":36265,"name":"Entropy","url":"https://www.academia.edu/Documents/in/Entropy"},{"id":46378,"name":"Ore Geology","url":"https://www.academia.edu/Documents/in/Ore_Geology"},{"id":81182,"name":"Deep Learning","url":"https://www.academia.edu/Documents/in/Deep_Learning"},{"id":149474,"name":"Anthropocene","url":"https://www.academia.edu/Documents/in/Anthropocene"},{"id":262841,"name":"Endocrine Disruption","url":"https://www.academia.edu/Documents/in/Endocrine_Disruption"},{"id":394528,"name":"Disruption","url":"https://www.academia.edu/Documents/in/Disruption"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43503048"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/43503048/Historicity_at_the_heart_of_biology"><img alt="Research paper thumbnail of Historicity at the heart of biology" class="work-thumbnail" src="https://attachments.academia-assets.com/63812968/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/43503048/Historicity_at_the_heart_of_biology">Historicity at the heart of biology</a></div><div class="wp-workCard_item"><span>Theory in Biosciences </span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Most mathematical modeling in biology relies either implicitly or explicitly on the epistemology ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Most mathematical modeling in biology relies either implicitly or explicitly on the epistemology of physics. The underlying conception is that the historicity of biological objects would not matter to understand a situation here and now, or, at least, historicity would not impact the method of modeling. We analyze that it is not the case with concrete examples. Historicity forces a conceptual reconfiguration where equations no longer play a central role. We argue that all observations depend on objects defined by their historical origin instead of their relations as in physics. Therefore, we propose that biological variations and historicity come first, and regularities are constraints with limited validity in biology. Their proper theoretical and empirical use requires specific rationales.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef87d1bddc6dfa06f55d7699f3f26a1e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63812968,"asset_id":43503048,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63812968/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43503048"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43503048"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43503048; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43503048]").text(description); $(".js-view-count[data-work-id=43503048]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43503048; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43503048']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 43503048, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ef87d1bddc6dfa06f55d7699f3f26a1e" } } $('.js-work-strip[data-work-id=43503048]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43503048,"title":"Historicity at the heart of biology","translated_title":"","metadata":{"doi":"10.1007/s12064-020-00320-8","abstract":"Most mathematical modeling in biology relies either implicitly or explicitly on the epistemology of physics. The underlying conception is that the historicity of biological objects would not matter to understand a situation here and now, or, at least, historicity would not impact the method of modeling. We analyze that it is not the case with concrete examples. Historicity forces a conceptual reconfiguration where equations no longer play a central role. We argue that all observations depend on objects defined by their historical origin instead of their relations as in physics. Therefore, we propose that biological variations and historicity come first, and regularities are constraints with limited validity in biology. Their proper theoretical and empirical use requires specific rationales.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Theory in Biosciences "},"translated_abstract":"Most mathematical modeling in biology relies either implicitly or explicitly on the epistemology of physics. The underlying conception is that the historicity of biological objects would not matter to understand a situation here and now, or, at least, historicity would not impact the method of modeling. We analyze that it is not the case with concrete examples. Historicity forces a conceptual reconfiguration where equations no longer play a central role. We argue that all observations depend on objects defined by their historical origin instead of their relations as in physics. Therefore, we propose that biological variations and historicity come first, and regularities are constraints with limited validity in biology. Their proper theoretical and empirical use requires specific rationales.","internal_url":"https://www.academia.edu/43503048/Historicity_at_the_heart_of_biology","translated_internal_url":"","created_at":"2020-07-02T15:26:31.121-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":35159257,"work_id":43503048,"tagging_user_id":28744524,"tagged_user_id":null,"co_author_invite_id":4270246,"email":"m***l@univ-paris1.fr","display_order":1,"name":"Maël Montévil","title":"Historicity at the heart of biology"}],"downloadable_attachments":[{"id":63812968,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63812968/thumbnails/1.jpg","file_name":"historicity20200702-15874-129q8l7.pdf","download_url":"https://www.academia.edu/attachments/63812968/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Historicity_at_the_heart_of_biology.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63812968/historicity20200702-15874-129q8l7-libre.pdf?1593729341=\u0026response-content-disposition=attachment%3B+filename%3DHistoricity_at_the_heart_of_biology.pdf\u0026Expires=1732359830\u0026Signature=clZwrsE14wYJg5H5QJ2LaIltiGyMLtYS7yb7k9It59lxgpLiBeyoHNgQRps11XA2tHfz~IUpcWj8YilIt2pd9zbMwjKXDFsgFuhitAHx4IOpeyln1iPhUwLwMK2m0W2gflVoLWiiPf9evdA7cE7GX4vJTCxeSue5t-CUoQ0c9mARH9IjrhqGTrgozXRupsiGSlIwRmKR-0Z6pKm-~HMV~GXH1ACG9rXboPxW4Ucg-EyPK-KCeEoIYMPsM9wGGFDJoLwn9sFYRZqNTnYMl3Ch3C4JtavGTc8dXO-w~cPZE4eEJiTR5cPx5s-bMc9hmGNR0ieuStGtHZvsc-9-tsMsiA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Historicity_at_the_heart_of_biology","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[{"id":63812968,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63812968/thumbnails/1.jpg","file_name":"historicity20200702-15874-129q8l7.pdf","download_url":"https://www.academia.edu/attachments/63812968/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Historicity_at_the_heart_of_biology.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63812968/historicity20200702-15874-129q8l7-libre.pdf?1593729341=\u0026response-content-disposition=attachment%3B+filename%3DHistoricity_at_the_heart_of_biology.pdf\u0026Expires=1732359830\u0026Signature=clZwrsE14wYJg5H5QJ2LaIltiGyMLtYS7yb7k9It59lxgpLiBeyoHNgQRps11XA2tHfz~IUpcWj8YilIt2pd9zbMwjKXDFsgFuhitAHx4IOpeyln1iPhUwLwMK2m0W2gflVoLWiiPf9evdA7cE7GX4vJTCxeSue5t-CUoQ0c9mARH9IjrhqGTrgozXRupsiGSlIwRmKR-0Z6pKm-~HMV~GXH1ACG9rXboPxW4Ucg-EyPK-KCeEoIYMPsM9wGGFDJoLwn9sFYRZqNTnYMl3Ch3C4JtavGTc8dXO-w~cPZE4eEJiTR5cPx5s-bMc9hmGNR0ieuStGtHZvsc-9-tsMsiA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":155,"name":"Evolutionary Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology"},{"id":502,"name":"Biophysics","url":"https://www.academia.edu/Documents/in/Biophysics"},{"id":821,"name":"Philosophy of Science","url":"https://www.academia.edu/Documents/in/Philosophy_of_Science"},{"id":823,"name":"Philosophy of Biology","url":"https://www.academia.edu/Documents/in/Philosophy_of_Biology"},{"id":1074,"name":"Organizational Theory","url":"https://www.academia.edu/Documents/in/Organizational_Theory"},{"id":8988,"name":"Instrumentation and Measurement Science","url":"https://www.academia.edu/Documents/in/Instrumentation_and_Measurement_Science"},{"id":16682,"name":"Mathematical Modelling","url":"https://www.academia.edu/Documents/in/Mathematical_Modelling"},{"id":24124,"name":"Morphogenesis","url":"https://www.academia.edu/Documents/in/Morphogenesis"},{"id":42465,"name":"Organizational Development","url":"https://www.academia.edu/Documents/in/Organizational_Development"},{"id":54023,"name":"Fine-Tuning","url":"https://www.academia.edu/Documents/in/Fine-Tuning"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43409703"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/43409703/The_Identity_of_Organisms_in_Scientific_Practice_Integrating_Historical_and_Relational_Conceptions"><img alt="Research paper thumbnail of The Identity of Organisms in Scientific Practice: Integrating Historical and Relational Conceptions" class="work-thumbnail" src="https://attachments.academia-assets.com/63709483/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/43409703/The_Identity_of_Organisms_in_Scientific_Practice_Integrating_Historical_and_Relational_Conceptions">The Identity of Organisms in Scientific Practice: Integrating Historical and Relational Conceptions</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://cnrs.academia.edu/MatteoMossio">Matteo Mossio</a></span></div><div class="wp-workCard_item"><span>Frontiers in physiology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We address the identity of biological organisms at play in experimental and modeling practices. W...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We address the identity of biological organisms at play in experimental and modeling practices. We first examine the central tenets of two general conceptions, and we assess their respective strengths and weaknesses. The historical conception, on the one hand, characterizes organisms' identity by looking at their past, and specifically at their genealogical connection with a common ancestor. The relational conception, on the other hand, interprets organisms' identity by referring to a set of distinctive relations between their parts, and between the organism and its environment. While the historical and relational conceptions are understood as opposed and conflicting, we submit that they are also fundamentally complementary. Accordingly, we put forward a hybrid conception, in which historical and relational (and more specifically, organizational) aspects of organisms' identity sustain and justify each other. Moreover, we argue that organisms' identity is not only hybrid but also bounded, insofar as the compliance with specific identity criteria tends to vanish as time passes, especially across generations. We spell out the core conceptual framework of this conception, and we outline an original formal representation. We contend that the hybrid and bounded conception of organisms' identity suits the epistemological needs of biological practices, particularly with regards to the generalization and reproducibility of experimental results, and the integration of mathematical models with experiments.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="71d0e745be6282b446daee399fdab2b7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63709483,"asset_id":43409703,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63709483/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43409703"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43409703"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43409703; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43409703]").text(description); $(".js-view-count[data-work-id=43409703]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43409703; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43409703']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 43409703, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "71d0e745be6282b446daee399fdab2b7" } } $('.js-work-strip[data-work-id=43409703]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43409703,"title":"The Identity of Organisms in Scientific Practice: Integrating Historical and Relational Conceptions","translated_title":"","metadata":{"doi":"10.3389/fphys.2020.00611","abstract":"We address the identity of biological organisms at play in experimental and modeling practices. We first examine the central tenets of two general conceptions, and we assess their respective strengths and weaknesses. The historical conception, on the one hand, characterizes organisms' identity by looking at their past, and specifically at their genealogical connection with a common ancestor. The relational conception, on the other hand, interprets organisms' identity by referring to a set of distinctive relations between their parts, and between the organism and its environment. While the historical and relational conceptions are understood as opposed and conflicting, we submit that they are also fundamentally complementary. Accordingly, we put forward a hybrid conception, in which historical and relational (and more specifically, organizational) aspects of organisms' identity sustain and justify each other. Moreover, we argue that organisms' identity is not only hybrid but also bounded, insofar as the compliance with specific identity criteria tends to vanish as time passes, especially across generations. We spell out the core conceptual framework of this conception, and we outline an original formal representation. We contend that the hybrid and bounded conception of organisms' identity suits the epistemological needs of biological practices, particularly with regards to the generalization and reproducibility of experimental results, and the integration of mathematical models with experiments.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Frontiers in physiology"},"translated_abstract":"We address the identity of biological organisms at play in experimental and modeling practices. We first examine the central tenets of two general conceptions, and we assess their respective strengths and weaknesses. The historical conception, on the one hand, characterizes organisms' identity by looking at their past, and specifically at their genealogical connection with a common ancestor. The relational conception, on the other hand, interprets organisms' identity by referring to a set of distinctive relations between their parts, and between the organism and its environment. While the historical and relational conceptions are understood as opposed and conflicting, we submit that they are also fundamentally complementary. Accordingly, we put forward a hybrid conception, in which historical and relational (and more specifically, organizational) aspects of organisms' identity sustain and justify each other. Moreover, we argue that organisms' identity is not only hybrid but also bounded, insofar as the compliance with specific identity criteria tends to vanish as time passes, especially across generations. We spell out the core conceptual framework of this conception, and we outline an original formal representation. We contend that the hybrid and bounded conception of organisms' identity suits the epistemological needs of biological practices, particularly with regards to the generalization and reproducibility of experimental results, and the integration of mathematical models with experiments.","internal_url":"https://www.academia.edu/43409703/The_Identity_of_Organisms_in_Scientific_Practice_Integrating_Historical_and_Relational_Conceptions","translated_internal_url":"","created_at":"2020-06-22T15:05:43.673-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":35071270,"work_id":43409703,"tagging_user_id":28744524,"tagged_user_id":235670,"co_author_invite_id":null,"email":"m***o@univ-paris1.fr","affiliation":"Centre National de la Recherche Scientifique / French National Centre for Scientific Research","display_order":1,"name":"Matteo Mossio","title":"The Identity of Organisms in Scientific Practice: Integrating Historical and Relational Conceptions"}],"downloadable_attachments":[{"id":63709483,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63709483/thumbnails/1.jpg","file_name":"fphys-11-0061120200622-105744-1u0eb8h.pdf","download_url":"https://www.academia.edu/attachments/63709483/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Identity_of_Organisms_in_Scientific.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63709483/fphys-11-0061120200622-105744-1u0eb8h-libre.pdf?1592864278=\u0026response-content-disposition=attachment%3B+filename%3DThe_Identity_of_Organisms_in_Scientific.pdf\u0026Expires=1732221638\u0026Signature=CSnWcDa4ZnQEliSJuKj3iw9Vrse7dEMpm3Hp1GUPbOhhkmDn5EACYJWcS-iUPpZyRWzG11JLe5DbG-v9aflBqVdEAw-iJp6qoBUmOWIfKuals30NnyOOhgFyp9~jCNhLrtEWlADxR51x9FYyTx~mrFNhgL1X0nq94cY00PiWVkaWc16lvjbWP~IQAfUSUVsJBI8Uz8r~q6U3F4-YzvRLNy7J1HEb9UyIa7fjmDUfjXurt97o-5B0~8XISBII6rbuIT~MQ1qlJJtnV5VQAXTMgLS9lF~fw~TdfCbRY5X4BsA~bTfemd2zMtHIR1U9NtOENP3BbE1FwJcgSoMB9l-b-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Identity_of_Organisms_in_Scientific_Practice_Integrating_Historical_and_Relational_Conceptions","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[{"id":63709483,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63709483/thumbnails/1.jpg","file_name":"fphys-11-0061120200622-105744-1u0eb8h.pdf","download_url":"https://www.academia.edu/attachments/63709483/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Identity_of_Organisms_in_Scientific.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63709483/fphys-11-0061120200622-105744-1u0eb8h-libre.pdf?1592864278=\u0026response-content-disposition=attachment%3B+filename%3DThe_Identity_of_Organisms_in_Scientific.pdf\u0026Expires=1732221638\u0026Signature=CSnWcDa4ZnQEliSJuKj3iw9Vrse7dEMpm3Hp1GUPbOhhkmDn5EACYJWcS-iUPpZyRWzG11JLe5DbG-v9aflBqVdEAw-iJp6qoBUmOWIfKuals30NnyOOhgFyp9~jCNhLrtEWlADxR51x9FYyTx~mrFNhgL1X0nq94cY00PiWVkaWc16lvjbWP~IQAfUSUVsJBI8Uz8r~q6U3F4-YzvRLNy7J1HEb9UyIa7fjmDUfjXurt97o-5B0~8XISBII6rbuIT~MQ1qlJJtnV5VQAXTMgLS9lF~fw~TdfCbRY5X4BsA~bTfemd2zMtHIR1U9NtOENP3BbE1FwJcgSoMB9l-b-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":155,"name":"Evolutionary Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology"},{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology"},{"id":821,"name":"Philosophy of Science","url":"https://www.academia.edu/Documents/in/Philosophy_of_Science"},{"id":823,"name":"Philosophy of Biology","url":"https://www.academia.edu/Documents/in/Philosophy_of_Biology"},{"id":972,"name":"Self and Identity","url":"https://www.academia.edu/Documents/in/Self_and_Identity"},{"id":1324,"name":"Organizational Change","url":"https://www.academia.edu/Documents/in/Organizational_Change"},{"id":2061,"name":"Genealogy","url":"https://www.academia.edu/Documents/in/Genealogy"},{"id":6288,"name":"Measurement and Evaluation","url":"https://www.academia.edu/Documents/in/Measurement_and_Evaluation"},{"id":16682,"name":"Mathematical Modelling","url":"https://www.academia.edu/Documents/in/Mathematical_Modelling"},{"id":26977,"name":"Theoretical biology","url":"https://www.academia.edu/Documents/in/Theoretical_biology"},{"id":37870,"name":"Organismal Biology","url":"https://www.academia.edu/Documents/in/Organismal_Biology"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43137804"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/43137804/A_Combined_Morphometric_and_Statistical_Approach_to_Assess_Nonmonotonicity_in_the_Developing_Mammary_Gland_of_Rats_in_the_CLARITY_BPA_Study"><img alt="Research paper thumbnail of A Combined Morphometric and Statistical Approach to Assess Nonmonotonicity in the Developing Mammary Gland of Rats in the CLARITY-BPA Study" class="work-thumbnail" src="https://attachments.academia-assets.com/63396940/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/43137804/A_Combined_Morphometric_and_Statistical_Approach_to_Assess_Nonmonotonicity_in_the_Developing_Mammary_Gland_of_Rats_in_the_CLARITY_BPA_Study">A Combined Morphometric and Statistical Approach to Assess Nonmonotonicity in the Developing Mammary Gland of Rats in the CLARITY-BPA Study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://tufts.academia.edu/AnaMSoto">Ana M Soto</a></span></div><div class="wp-workCard_item"><span>Environmental Health Perspectives</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND: The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND: The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES: We aimed to a) determine whether BPA showed effects on the developing rat mammary gland using new quantitative and established semiquantitative methods in two laboratories, b) develop a software tool for automatic evaluation of quantifiable aspects of the mammary ductal tree, and c) compare those methods. METHODS: Sprague-Dawley rats were exposed to BPA, vehicle, or positive control [ethinyl estradiol (EE2)] by oral gavage beginning on gestational day (GD)6 and continuing with direct dosing of the pups after birth. There were two studies: subchronic and chronic. The latter used two exposure regimes, one stopping at postnatal day (PND)21 (stop-dose) the other continuing until tissue harvest (continuous). Glands were harvested at multiple time points; whole mounts and histological specimens were analyzed blinded to treatment. RESULTS: The subchronic study's semiquantitative analysis revealed no significant differences between control and BPA dose groups at PND21, whereas at PND90 there were significant differences between control and the lowest BPA dose and between control and the lowest EE2 dose in animals in estrus. Quantitative, automatized analysis of the chronic PND21 specimens displayed nonmonotonic BPA effects, with a breaking point between the 25 and 250 lg=kg body weight (BW) per day doses. This breaking point was confirmed by a global statistical analysis of chronic study animals at PND90 and 6 months analyzed by the quantitative method. The BPA response was different from the EE2 effect for many features. CONCLUSIONS: Both the semiquantitative and the quantitative methods revealed nonmonotonic effects of BPA. The quantitative unsupervised analysis used 91 measurements and produced the most striking nonmonotonic dose-response curves. At all time points, lower doses resulted in larger effects, consistent with the core study, which revealed a significant increase of mammary adenocarcinoma incidence in the stop-dose animals at the lowest BPA dose tested.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ebfc76ff7cbfffce083eb496e6328f77" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63396940,"asset_id":43137804,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63396940/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43137804"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43137804"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43137804; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43137804]").text(description); $(".js-view-count[data-work-id=43137804]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43137804; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43137804']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 43137804, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ebfc76ff7cbfffce083eb496e6328f77" } } $('.js-work-strip[data-work-id=43137804]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43137804,"title":"A Combined Morphometric and Statistical Approach to Assess Nonmonotonicity in the Developing Mammary Gland of Rats in the CLARITY-BPA Study","translated_title":"","metadata":{"doi":"10.1289/EHP6301","abstract":"BACKGROUND: The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES: We aimed to a) determine whether BPA showed effects on the developing rat mammary gland using new quantitative and established semiquantitative methods in two laboratories, b) develop a software tool for automatic evaluation of quantifiable aspects of the mammary ductal tree, and c) compare those methods. METHODS: Sprague-Dawley rats were exposed to BPA, vehicle, or positive control [ethinyl estradiol (EE2)] by oral gavage beginning on gestational day (GD)6 and continuing with direct dosing of the pups after birth. There were two studies: subchronic and chronic. The latter used two exposure regimes, one stopping at postnatal day (PND)21 (stop-dose) the other continuing until tissue harvest (continuous). Glands were harvested at multiple time points; whole mounts and histological specimens were analyzed blinded to treatment. RESULTS: The subchronic study's semiquantitative analysis revealed no significant differences between control and BPA dose groups at PND21, whereas at PND90 there were significant differences between control and the lowest BPA dose and between control and the lowest EE2 dose in animals in estrus. Quantitative, automatized analysis of the chronic PND21 specimens displayed nonmonotonic BPA effects, with a breaking point between the 25 and 250 lg=kg body weight (BW) per day doses. This breaking point was confirmed by a global statistical analysis of chronic study animals at PND90 and 6 months analyzed by the quantitative method. The BPA response was different from the EE2 effect for many features. CONCLUSIONS: Both the semiquantitative and the quantitative methods revealed nonmonotonic effects of BPA. The quantitative unsupervised analysis used 91 measurements and produced the most striking nonmonotonic dose-response curves. At all time points, lower doses resulted in larger effects, consistent with the core study, which revealed a significant increase of mammary adenocarcinoma incidence in the stop-dose animals at the lowest BPA dose tested. ","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Environmental Health Perspectives"},"translated_abstract":"BACKGROUND: The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES: We aimed to a) determine whether BPA showed effects on the developing rat mammary gland using new quantitative and established semiquantitative methods in two laboratories, b) develop a software tool for automatic evaluation of quantifiable aspects of the mammary ductal tree, and c) compare those methods. METHODS: Sprague-Dawley rats were exposed to BPA, vehicle, or positive control [ethinyl estradiol (EE2)] by oral gavage beginning on gestational day (GD)6 and continuing with direct dosing of the pups after birth. There were two studies: subchronic and chronic. The latter used two exposure regimes, one stopping at postnatal day (PND)21 (stop-dose) the other continuing until tissue harvest (continuous). Glands were harvested at multiple time points; whole mounts and histological specimens were analyzed blinded to treatment. RESULTS: The subchronic study's semiquantitative analysis revealed no significant differences between control and BPA dose groups at PND21, whereas at PND90 there were significant differences between control and the lowest BPA dose and between control and the lowest EE2 dose in animals in estrus. Quantitative, automatized analysis of the chronic PND21 specimens displayed nonmonotonic BPA effects, with a breaking point between the 25 and 250 lg=kg body weight (BW) per day doses. This breaking point was confirmed by a global statistical analysis of chronic study animals at PND90 and 6 months analyzed by the quantitative method. The BPA response was different from the EE2 effect for many features. CONCLUSIONS: Both the semiquantitative and the quantitative methods revealed nonmonotonic effects of BPA. The quantitative unsupervised analysis used 91 measurements and produced the most striking nonmonotonic dose-response curves. At all time points, lower doses resulted in larger effects, consistent with the core study, which revealed a significant increase of mammary adenocarcinoma incidence in the stop-dose animals at the lowest BPA dose tested. 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href="https://www.academia.edu/40232744/Which_first_principles_for_mathematical_modelling_in_biology"><img alt="Research paper thumbnail of Which first principles for mathematical modelling in biology" class="work-thumbnail" src="https://attachments.academia-assets.com/60463460/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/40232744/Which_first_principles_for_mathematical_modelling_in_biology">Which first principles for mathematical modelling in biology</a></div><div class="wp-workCard_item"><span>Rendiconti di Matematica e delle sue Applicazioni</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Like theoretical physics, theoretical biology is not just mathematical modeling. Instead, theoret...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Like theoretical physics, theoretical biology is not just mathematical modeling. Instead, theoretical biology should strive to find suitable first principles to ground the understanding of biological phenomena and ultimately frame biological experiments and mathematical models. First principles in physics are expressed in terms of symmetries and the associated conservations, on the one side, and optimization on the other side. In biology, we argue instead that a strong notion of variation is fundamental. This notion encompasses new possibilities and the historicity of biological phenomena. By contrast, the relative regularity of some aspects of biological organisms, which we call constraints, should be regarded as the consequence of a mutual stabilization of the parts of organisms. We exemplify several aspects of this framework with the modeling of allometric relationships. Our change of perspective leads to reconsider the meaning of measurements and the structure of the space of description.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2fa5ce5891169d127b7e33ca881a9615" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":60463460,"asset_id":40232744,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/60463460/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="40232744"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="40232744"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 40232744; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=40232744]").text(description); $(".js-view-count[data-work-id=40232744]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 40232744; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='40232744']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 40232744, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2fa5ce5891169d127b7e33ca881a9615" } } $('.js-work-strip[data-work-id=40232744]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":40232744,"title":"Which first principles for mathematical modelling in biology","translated_title":"","metadata":{"abstract":"Like theoretical physics, theoretical biology is not just mathematical modeling. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="38904550"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/38904550/Measurement_in_biology_is_methodized_by_theory"><img alt="Research paper thumbnail of Measurement in biology is methodized by theory" class="work-thumbnail" src="https://attachments.academia-assets.com/59003420/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/38904550/Measurement_in_biology_is_methodized_by_theory">Measurement in biology is methodized by theory</a></div><div class="wp-workCard_item"><span>Biology & Philosophy</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We characterize access to empirical objects in biology from a theoretical perspective. Unlike obj...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We characterize access to empirical objects in biology from a theoretical perspective. Unlike objects in current physical theories, biological objects are the result of a history and their variations continue to generate a history. This property is the starting point of our concept of measurement. We argue that biological measurement is relative to a natural history which is shared by the different objects subjected to the measurement and is more or less constrained by biologists. We call symmetrization the theoretical and often concrete operation which leads to considering biological objects as equivalent in a measurement.  Last, we use our notion of measurement to analyze research strategies. Some strategies aim to bring biology closer to the epistemology of physical theories, by studying objects as similar as possible, while others build on biological diversity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="791c42a7e5b365e0e6ab745bf839a912" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":59003420,"asset_id":38904550,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/59003420/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="38904550"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="38904550"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 38904550; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=38904550]").text(description); $(".js-view-count[data-work-id=38904550]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 38904550; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='38904550']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 38904550, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "791c42a7e5b365e0e6ab745bf839a912" } } $('.js-work-strip[data-work-id=38904550]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":38904550,"title":"Measurement in biology is methodized by theory","translated_title":"","metadata":{"doi":"10.1007/s10539-019-9687-x","issue":"3","volume":"34","abstract":"We characterize access to empirical objects in biology from a theoretical perspective. 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Some strategies aim to bring biology closer to the epistemology of physical theories, by studying objects as similar as possible, while others build on biological diversity. 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="2800723" id="papers"><div class="js-work-strip profile--work_container" data-work-id="70740145"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70740145/Conceptual_and_theoretical_specifications_for_accuracy_in_medicine_"><img alt="Research paper thumbnail of Conceptual and theoretical specifications for accuracy in medicine *" class="work-thumbnail" src="https://attachments.academia-assets.com/80362350/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70740145/Conceptual_and_theoretical_specifications_for_accuracy_in_medicine_">Conceptual and theoretical specifications for accuracy in medicine *</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Technological developments in genomics and other -omics originated the idea that precise measurem...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Technological developments in genomics and other -omics originated the idea that precise measurements would lead to better therapeutic strategies. However, precision does not entail accuracy. Scientific accuracy requires a theoretical framework to understand the meaning of measurements, the nature of causal relationships, and potential intrinsic limitations of knowledge. For example, a precise measurement of initial positions in classical mechanics is useless without initial velocities; it is not an accurate measurement of the initial condition. Conceptual and theoretical accuracy is required for precision to lead to the progress of knowledge and rationality in action. In the search for accuracy in medicine, we first outline our results on a theory of organisms. Biology is distinct from physics and requires a specific epistemology. In particular, we develop the meaning of biological measurements and emphasize that variability and historicity are fundamental notions. However, medicin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b548a1942b3b257976fa151da317f9fc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80362350,"asset_id":70740145,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80362350/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740145"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740145"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740145; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740145]").text(description); $(".js-view-count[data-work-id=70740145]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740145; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740145']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740145, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b548a1942b3b257976fa151da317f9fc" } } $('.js-work-strip[data-work-id=70740145]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740145,"title":"Conceptual and theoretical specifications for accuracy in medicine *","translated_title":"","metadata":{"abstract":"Technological developments in genomics and other -omics originated the idea that precise measurements would lead to better therapeutic strategies. However, precision does not entail accuracy. Scientific accuracy requires a theoretical framework to understand the meaning of measurements, the nature of causal relationships, and potential intrinsic limitations of knowledge. For example, a precise measurement of initial positions in classical mechanics is useless without initial velocities; it is not an accurate measurement of the initial condition. Conceptual and theoretical accuracy is required for precision to lead to the progress of knowledge and rationality in action. In the search for accuracy in medicine, we first outline our results on a theory of organisms. Biology is distinct from physics and requires a specific epistemology. In particular, we develop the meaning of biological measurements and emphasize that variability and historicity are fundamental notions. However, medicin...","publication_date":{"day":null,"month":null,"year":2020,"errors":{}}},"translated_abstract":"Technological developments in genomics and other -omics originated the idea that precise measurements would lead to better therapeutic strategies. However, precision does not entail accuracy. Scientific accuracy requires a theoretical framework to understand the meaning of measurements, the nature of causal relationships, and potential intrinsic limitations of knowledge. For example, a precise measurement of initial positions in classical mechanics is useless without initial velocities; it is not an accurate measurement of the initial condition. Conceptual and theoretical accuracy is required for precision to lead to the progress of knowledge and rationality in action. In the search for accuracy in medicine, we first outline our results on a theory of organisms. Biology is distinct from physics and requires a specific epistemology. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70740144"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70740144/The_Hitchhiker_s_Guide_to_the_Cancer_Galaxy_How_two_critics_missed_their_destination"><img alt="Research paper thumbnail of The Hitchhiker’s Guide to the Cancer Galaxy: How two critics missed their destination" class="work-thumbnail" src="https://attachments.academia-assets.com/80362346/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70740144/The_Hitchhiker_s_Guide_to_the_Cancer_Galaxy_How_two_critics_missed_their_destination">The Hitchhiker’s Guide to the Cancer Galaxy: How two critics missed their destination</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Two main theories aim at understanding carcinogenesis: the reductionist smt locates cancer in can...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Two main theories aim at understanding carcinogenesis: the reductionist smt locates cancer in cancer cells, while the organicist toft locates cancer at the tissue level. For toft , the ‘cancer cell’ is a phlogiston, smt is an old paradigm which ought to be replaced. Recently two critics have argued that toft and smt , despite their apparent strong incompatibilities, are actually compatible. Here we review their arguments. We show that these arguments are based on interpretation mistakes that become understandable once one grants that criticizing a paradigm from the point of view of another, in which words do not have the same signification, bears the risk of strong misunderstandings. These misunderstandings, in our experience, are common. We hope that this discussion will help clarifying the differences between toft and smt .</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5686200fa7b585235454282cb945a3c2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80362346,"asset_id":70740144,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80362346/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740144"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740144"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740144; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740144]").text(description); $(".js-view-count[data-work-id=70740144]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740144; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740144']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740144, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5686200fa7b585235454282cb945a3c2" } } $('.js-work-strip[data-work-id=70740144]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740144,"title":"The Hitchhiker’s Guide to the Cancer Galaxy: How two critics missed their destination","translated_title":"","metadata":{"abstract":"Two main theories aim at understanding carcinogenesis: the reductionist smt locates cancer in cancer cells, while the organicist toft locates cancer at the tissue level. 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Biological identity can be defined either diachronically by looking at the past of individual organisms, or synchronically by referring to the relational description of their organization and interaction with the environment. A possible stance would consist in taking them as alternative and competing conceptions. In this paper, we put forward a different position, according to which there is a fundamental complementarity between them. The identity of biological objects is hybrid, insofar as it lies at the crossroad between the diachronic and synchronic conceptions. In addition, we submit that biological identity is also bounded, because the compliance with specific criteria tends to vanish as time passes, especially across generations. We spell out the resulting conceptual framework, and outline a formal representation of such hybrid and bounded identity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740143"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740143"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740143; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740143]").text(description); $(".js-view-count[data-work-id=70740143]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740143; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740143']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740143, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=70740143]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740143,"title":"Biological identity at the crossroad between historical and relational conceptions","translated_title":"","metadata":{"abstract":"We address1 the identity of biological organisms by examining two distinct conceptions at work in theoretical and empirical work. Biological identity can be defined either diachronically by looking at the past of individual organisms, or synchronically by referring to the relational description of their organization and interaction with the environment. A possible stance would consist in taking them as alternative and competing conceptions. In this paper, we put forward a different position, according to which there is a fundamental complementarity between them. The identity of biological objects is hybrid, insofar as it lies at the crossroad between the diachronic and synchronic conceptions. In addition, we submit that biological identity is also bounded, because the compliance with specific criteria tends to vanish as time passes, especially across generations. 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In addition, we submit that biological identity is also bounded, because the compliance with specific criteria tends to vanish as time passes, especially across generations. We spell out the resulting conceptual framework, and outline a formal representation of such hybrid and bounded identity.","internal_url":"https://www.academia.edu/70740143/Biological_identity_at_the_crossroad_between_historical_and_relational_conceptions","translated_internal_url":"","created_at":"2022-02-06T12:20:10.296-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Biological_identity_at_the_crossroad_between_historical_and_relational_conceptions","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[],"research_interests":[],"urls":[{"id":17384687,"url":"https://montevil.theobio.org/en/system/files/articlepdf/identity-web.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70740142"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70740142/SAMA_A_Method_for_3_D_Morphological_Analysis"><img alt="Research paper thumbnail of SAMA : A Method for 3 D Morphological Analysis" class="work-thumbnail" src="https://attachments.academia-assets.com/80362344/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70740142/SAMA_A_Method_for_3_D_Morphological_Analysis">SAMA : A Method for 3 D Morphological Analysis</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Three-dimensional (3D) culture models are critical tools for understanding tissue morphogenesis. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Three-dimensional (3D) culture models are critical tools for understanding tissue morphogenesis. A key requirement for their analysis is the ability to reconstruct the tissue into computational models that allow quantitative evaluation of the formed structures. Here, we present Software for Automated Morphological Analysis (SAMA), a method by which epithelial structures grown in 3D cultures can be imaged, reconstructed and analyzed with minimum human intervention. SAMA allows quantitative analysis of key features of epithelial morphogenesis such as ductal elongation, branching and lumen formation that distinguish different hormonal treatments. SAMA is a user-friendly set of customized macros operated via FIJI (<a href="http://fiji.sc/Fiji" rel="nofollow">http://fiji.sc/Fiji</a>), an open-source image analysis platform in combination with a set of functions in R (<a href="http://www.r-project.org/" rel="nofollow">http://www.r-project.org/</a>), an open-source program for statistical analysis. SAMA enables a rapid, exhaustive and quantitative 3D analysis of the shape of a population of ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e2f97da5c18164b2c32dfeb62d5ef6cc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80362344,"asset_id":70740142,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80362344/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740142"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740142"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740142; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740142]").text(description); $(".js-view-count[data-work-id=70740142]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740142; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740142']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740142, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e2f97da5c18164b2c32dfeb62d5ef6cc" } } $('.js-work-strip[data-work-id=70740142]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740142,"title":"SAMA : A Method for 3 D Morphological Analysis","translated_title":"","metadata":{"abstract":"Three-dimensional (3D) culture models are critical tools for understanding tissue morphogenesis. A key requirement for their analysis is the ability to reconstruct the tissue into computational models that allow quantitative evaluation of the formed structures. Here, we present Software for Automated Morphological Analysis (SAMA), a method by which epithelial structures grown in 3D cultures can be imaged, reconstructed and analyzed with minimum human intervention. SAMA allows quantitative analysis of key features of epithelial morphogenesis such as ductal elongation, branching and lumen formation that distinguish different hormonal treatments. SAMA is a user-friendly set of customized macros operated via FIJI (http://fiji.sc/Fiji), an open-source image analysis platform in combination with a set of functions in R (http://www.r-project.org/), an open-source program for statistical analysis. SAMA enables a rapid, exhaustive and quantitative 3D analysis of the shape of a population of ...","publication_date":{"day":null,"month":null,"year":2016,"errors":{}}},"translated_abstract":"Three-dimensional (3D) culture models are critical tools for understanding tissue morphogenesis. A key requirement for their analysis is the ability to reconstruct the tissue into computational models that allow quantitative evaluation of the formed structures. Here, we present Software for Automated Morphological Analysis (SAMA), a method by which epithelial structures grown in 3D cultures can be imaged, reconstructed and analyzed with minimum human intervention. SAMA allows quantitative analysis of key features of epithelial morphogenesis such as ductal elongation, branching and lumen formation that distinguish different hormonal treatments. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70740139"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70740139/Big_Data_and_Biological_Knowledge_12"><img alt="Research paper thumbnail of Big Data and Biological Knowledge 12" class="work-thumbnail" src="https://attachments.academia-assets.com/80362343/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70740139/Big_Data_and_Biological_Knowledge_12">Big Data and Biological Knowledge 12</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Some authors assert that the analysis of huge databases could replace the scientific method. On t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Some authors assert that the analysis of huge databases could replace the scientific method. On the contrary, we argue that the best way to make these new technologies bear fruits is to frame them with theories concerning the phenomena of interest. Such theories hint to the observable that should be taken into account and the mathematical structures that may link them. In biology, we argue that the community urgently needs an overarching theory of organisms that would provide a precise framework to understand lifecycles. Among other benefits, such a theory should make explicit what we can and cannot predict in principle.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="16ccd3c6d106a77e4a85b9b7f2f354da" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80362343,"asset_id":70740139,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80362343/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740139"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740139"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740139; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740139]").text(description); $(".js-view-count[data-work-id=70740139]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740139; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740139']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740139, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "16ccd3c6d106a77e4a85b9b7f2f354da" } } $('.js-work-strip[data-work-id=70740139]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740139,"title":"Big Data and Biological Knowledge 12","translated_title":"","metadata":{"abstract":"Some authors assert that the analysis of huge databases could replace the scientific method. 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Ici, nous présentons et articulons brièvement les trois principes proposés récemment pour une théorie des organismes, à savoir : l&#39;état par défaut, prolifération avec variation et motilité, le principe de variation et le principe d&#39;organisation. Ces principes modifient profondément les observables biologiques et leur nature théorique par rapport aux cadres des théories physiques. 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they continually ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Organisms, whether uni or multi-cellular, are agents that make their own norms; they continually express their ability to generate novelty and stability, that is to say they combine plasticity and robustness. Here, we briefly present and describe the three main principles that our group proposes for a theory of organisms, namely: the default state, proliferation with variation and motility, the principle of variation and the principle of organization. These principles profoundly modify biological observables and their theoretical nature compared to the situation in physical theories. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70740134"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70740134/Temps_biologique_et_transitions_critiques_%C3%A9tendues_Vers_une_objectivation_de_l_%C3%A9tat_vivant_de_la_mati%C3%A8re"><img alt="Research paper thumbnail of Temps biologique et transitions critiques étendues : Vers une objectivation de l’état vivant de la matière" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70740134/Temps_biologique_et_transitions_critiques_%C3%A9tendues_Vers_une_objectivation_de_l_%C3%A9tat_vivant_de_la_mati%C3%A8re">Temps biologique et transitions critiques étendues : Vers une objectivation de l’état vivant de la matière</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This work takes place in the context of a theoretical approach in biology which uses the examples...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This work takes place in the context of a theoretical approach in biology which uses the examples of objectivation in physical theories without reducing biological phenomenalities to them. We begin by investigating the empirical biological scaling relationships found in the literature (allometric relationships, fractals, …), including their variability. We will then consider two different aspects of biological time. First, we will develop the notions of protension and retention as an account of local organization of biological time. Then we consider a supplementary temporal dimension to accommodate proper biological rhythms. Since the notion of symmetry plays a foundational role in physics, we investigate its possible role in biology. In relation with the notion of extended critical transitions, we propose the hypothesis that organisms and evolution can be understood as characterized by ubiquitous symmetry changes. This transform the status of biological objects, provides an approac...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740134"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740134"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740134; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740134]").text(description); $(".js-view-count[data-work-id=70740134]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740134; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740134']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740134, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=70740134]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740134,"title":"Temps biologique et transitions critiques étendues : Vers une objectivation de l’état vivant de la matière","translated_title":"","metadata":{"abstract":"This work takes place in the context of a theoretical approach in biology which uses the examples of objectivation in physical theories without reducing biological phenomenalities to them. 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In relation with the notion of extended critical transitions, we propose the hypothesis that organisms and evolution can be understood as characterized by ubiquitous symmetry changes. This transform the status of biological objects, provides an approac...","internal_url":"https://www.academia.edu/70740134/Temps_biologique_et_transitions_critiques_%C3%A9tendues_Vers_une_objectivation_de_l_%C3%A9tat_vivant_de_la_mati%C3%A8re","translated_internal_url":"","created_at":"2022-02-06T12:20:09.219-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Temps_biologique_et_transitions_critiques_étendues_Vers_une_objectivation_de_l_état_vivant_de_la_matière","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70740104"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70740104/Randomness_increases_biological_organization_a_mathematical_understanding_of_Goulds_critique_of_evolutionary_progress_1"><img alt="Research paper thumbnail of Randomness increases biological organization: a mathematical understanding of Gould's critique of evolutionary progress 1" class="work-thumbnail" src="https://attachments.academia-assets.com/80362306/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70740104/Randomness_increases_biological_organization_a_mathematical_understanding_of_Goulds_critique_of_evolutionary_progress_1">Randomness increases biological organization: a mathematical understanding of Gould's critique of evolutionary progress 1</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this text, we informally expose the mathematical analysis in [BL09] of Gould’s ideas on the in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this text, we informally expose the mathematical analysis in [BL09] of Gould’s ideas on the increase of “complexity” along biological evolution as a result of random paths. We also revisit some related theoretical investigations on randomness (contingency) and symmetry breakings in biology, following [LM12]. Gould made several fundamental observations on how phenotypic complexity increases on average, in a random evolution, without a bias towards an increase. Technically, we understand complexity as anti-entropy, a proper biological observable. Its increase, by symmetry changes, involves a strong form of randomness. In more usual biological terms, an increase of complexity involves new elements of biological organization and the latter are “contingent” because they are not determined by the current state of the life dynamics. 1 Randomness and Complexification in Evolution. Available energy consumption and transformation, thus entropy production, are the unavoidable physical proce...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="91b3a4f207679516c34da6a2572bbc20" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80362306,"asset_id":70740104,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80362306/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70740104"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70740104"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70740104; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70740104]").text(description); $(".js-view-count[data-work-id=70740104]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70740104; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70740104']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70740104, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "91b3a4f207679516c34da6a2572bbc20" } } $('.js-work-strip[data-work-id=70740104]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70740104,"title":"Randomness increases biological organization: a mathematical understanding of Gould's critique of evolutionary progress 1","translated_title":"","metadata":{"abstract":"In this text, we informally expose the mathematical analysis in [BL09] of Gould’s ideas on the increase of “complexity” along biological evolution as a result of random paths. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="64814573"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/64814573/Bifurquer_Il_ny_a_pas_dalternative"><img alt="Research paper thumbnail of Bifurquer: Il n'y a pas d'alternative" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/64814573/Bifurquer_Il_ny_a_pas_dalternative">Bifurquer: Il n'y a pas d'alternative</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ce livre – remarquablement documente tant dans les idees et les propositions que dans les pratiqu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ce livre – remarquablement documente tant dans les idees et les propositions que dans les pratiques qui essaiment deja dans certaines villes ou pays – dessine le monde tel qu’il devrait etre pour repondre aux grandes crises sanitaires, climatiques, sociales ou psychiques. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48948563"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48948563/Montevil_Entropies_Anthropocene"><img alt="Research paper thumbnail of Montevil Entropies Anthropocene" class="work-thumbnail" src="https://attachments.academia-assets.com/67346304/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48948563/Montevil_Entropies_Anthropocene">Montevil Entropies Anthropocene</a></div><div class="wp-workCard_item"><span>Ai And society</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Anthropocene crisis is frequently described as the rarefaction of resources or resources per ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Anthropocene crisis is frequently described as the rarefaction of resources or resources per capita. However, both energy and minerals correspond to fundamentally conserved quantities from the perspective of physics. A specific concept is required to understand the rarefaction of available resources. This concept, entropy, pertains to energy and matter configurations and not just to their sheer amount.<br />However, the physics concept of entropy is insufficient to understand biological and social organizations. Biological phenomena display both historicity and systemic properties. A biological organization, the ability of a specific living being to last over time, results from history, expresses itself by systemic properties, and may require generating novelties The concept of anti-entropy stems from the combination of these features. We propose that Anthropocene changes disrupt biological organizations by randomizing them, that is, decreasing anti-entropy. Moreover, second-order disruptions correspond to the decline of the ability to produce functional novelties, that is, to produce anti-entropy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="edb419bb5938366fa77cd17cd0ec6d61" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67346304,"asset_id":48948563,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67346304/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48948563"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48948563"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48948563; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48948563]").text(description); $(".js-view-count[data-work-id=48948563]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48948563; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48948563']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 48948563, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "edb419bb5938366fa77cd17cd0ec6d61" } } $('.js-work-strip[data-work-id=48948563]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48948563,"title":"Montevil Entropies Anthropocene","translated_title":"","metadata":{"doi":"10.1007/s00146-021-01221-0","abstract":"The Anthropocene crisis is frequently described as the rarefaction of resources or resources per capita. 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Moreover, second-order disruptions correspond to the decline of the ability to produce functional novelties, that is, to produce anti-entropy.","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Ai And society"},"translated_abstract":"The Anthropocene crisis is frequently described as the rarefaction of resources or resources per capita. However, both energy and minerals correspond to fundamentally conserved quantities from the perspective of physics. A specific concept is required to understand the rarefaction of available resources. This concept, entropy, pertains to energy and matter configurations and not just to their sheer amount.\nHowever, the physics concept of entropy is insufficient to understand biological and social organizations. Biological phenomena display both historicity and systemic properties. A biological organization, the ability of a specific living being to last over time, results from history, expresses itself by systemic properties, and may require generating novelties The concept of anti-entropy stems from the combination of these features. We propose that Anthropocene changes disrupt biological organizations by randomizing them, that is, decreasing anti-entropy. Moreover, second-order disruptions correspond to the decline of the ability to produce functional novelties, that is, to produce anti-entropy.","internal_url":"https://www.academia.edu/48948563/Montevil_Entropies_Anthropocene","translated_internal_url":"","created_at":"2021-05-17T05:53:16.124-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":67346304,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67346304/thumbnails/1.jpg","file_name":"2021_Montevil_Entropies_Anthropocene.pdf","download_url":"https://www.academia.edu/attachments/67346304/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Montevil_Entropies_Anthropocene.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67346304/2021_Montevil_Entropies_Anthropocene-libre.pdf?1621257434=\u0026response-content-disposition=attachment%3B+filename%3DMontevil_Entropies_Anthropocene.pdf\u0026Expires=1732221638\u0026Signature=QCiMW7g9zfsnEfFCLJc1-ZPXDeB-2XTgp1Ysi2aW60UE7nn-HhKdjvJWM1zEsp1yPveATAJ7IDnmw2gjGuY2bpWpggHmG1fFa4xHWD1BhjqilQ6O4gaXL9j8MXztdil5GV0FO2xHyIp1IIzjeb66PuKmqajYfDNC7fu3x6oS~Z4gNW-~DMBf0z9IAHOIZeBNV7FtLbvGBdIsK6trjwRLeP129pbIMQMAkn6OUHhrUKAVmY2jvFYjlZ9F5bACQq3LVXvBmCYWVjDa1dCN8QiK6kqwaTP8mFRsK8weytJsmpJv0cGY9JTfhJLgwtWePbuSPcuYyHk74opYF8bkNkYBww__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Montevil_Entropies_Anthropocene","translated_slug":"","page_count":32,"language":"en","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[{"id":67346304,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67346304/thumbnails/1.jpg","file_name":"2021_Montevil_Entropies_Anthropocene.pdf","download_url":"https://www.academia.edu/attachments/67346304/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Montevil_Entropies_Anthropocene.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67346304/2021_Montevil_Entropies_Anthropocene-libre.pdf?1621257434=\u0026response-content-disposition=attachment%3B+filename%3DMontevil_Entropies_Anthropocene.pdf\u0026Expires=1732221638\u0026Signature=QCiMW7g9zfsnEfFCLJc1-ZPXDeB-2XTgp1Ysi2aW60UE7nn-HhKdjvJWM1zEsp1yPveATAJ7IDnmw2gjGuY2bpWpggHmG1fFa4xHWD1BhjqilQ6O4gaXL9j8MXztdil5GV0FO2xHyIp1IIzjeb66PuKmqajYfDNC7fu3x6oS~Z4gNW-~DMBf0z9IAHOIZeBNV7FtLbvGBdIsK6trjwRLeP129pbIMQMAkn6OUHhrUKAVmY2jvFYjlZ9F5bACQq3LVXvBmCYWVjDa1dCN8QiK6kqwaTP8mFRsK8weytJsmpJv0cGY9JTfhJLgwtWePbuSPcuYyHk74opYF8bkNkYBww__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":2008,"name":"Machine Learning","url":"https://www.academia.edu/Documents/in/Machine_Learning"},{"id":18612,"name":"Pollination ecology","url":"https://www.academia.edu/Documents/in/Pollination_ecology"},{"id":22142,"name":"Ecosystem health","url":"https://www.academia.edu/Documents/in/Ecosystem_health"},{"id":23032,"name":"Tribology","url":"https://www.academia.edu/Documents/in/Tribology"},{"id":30347,"name":"Translation","url":"https://www.academia.edu/Documents/in/Translation"},{"id":36265,"name":"Entropy","url":"https://www.academia.edu/Documents/in/Entropy"},{"id":46378,"name":"Ore Geology","url":"https://www.academia.edu/Documents/in/Ore_Geology"},{"id":81182,"name":"Deep Learning","url":"https://www.academia.edu/Documents/in/Deep_Learning"},{"id":149474,"name":"Anthropocene","url":"https://www.academia.edu/Documents/in/Anthropocene"},{"id":262841,"name":"Endocrine Disruption","url":"https://www.academia.edu/Documents/in/Endocrine_Disruption"},{"id":394528,"name":"Disruption","url":"https://www.academia.edu/Documents/in/Disruption"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43503048"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/43503048/Historicity_at_the_heart_of_biology"><img alt="Research paper thumbnail of Historicity at the heart of biology" class="work-thumbnail" src="https://attachments.academia-assets.com/63812968/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/43503048/Historicity_at_the_heart_of_biology">Historicity at the heart of biology</a></div><div class="wp-workCard_item"><span>Theory in Biosciences </span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Most mathematical modeling in biology relies either implicitly or explicitly on the epistemology ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Most mathematical modeling in biology relies either implicitly or explicitly on the epistemology of physics. The underlying conception is that the historicity of biological objects would not matter to understand a situation here and now, or, at least, historicity would not impact the method of modeling. We analyze that it is not the case with concrete examples. Historicity forces a conceptual reconfiguration where equations no longer play a central role. We argue that all observations depend on objects defined by their historical origin instead of their relations as in physics. Therefore, we propose that biological variations and historicity come first, and regularities are constraints with limited validity in biology. Their proper theoretical and empirical use requires specific rationales.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef87d1bddc6dfa06f55d7699f3f26a1e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63812968,"asset_id":43503048,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63812968/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43503048"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43503048"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43503048; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43503048]").text(description); $(".js-view-count[data-work-id=43503048]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43503048; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43503048']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 43503048, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ef87d1bddc6dfa06f55d7699f3f26a1e" } } $('.js-work-strip[data-work-id=43503048]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43503048,"title":"Historicity at the heart of biology","translated_title":"","metadata":{"doi":"10.1007/s12064-020-00320-8","abstract":"Most mathematical modeling in biology relies either implicitly or explicitly on the epistemology of physics. The underlying conception is that the historicity of biological objects would not matter to understand a situation here and now, or, at least, historicity would not impact the method of modeling. We analyze that it is not the case with concrete examples. Historicity forces a conceptual reconfiguration where equations no longer play a central role. We argue that all observations depend on objects defined by their historical origin instead of their relations as in physics. Therefore, we propose that biological variations and historicity come first, and regularities are constraints with limited validity in biology. Their proper theoretical and empirical use requires specific rationales.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Theory in Biosciences "},"translated_abstract":"Most mathematical modeling in biology relies either implicitly or explicitly on the epistemology of physics. The underlying conception is that the historicity of biological objects would not matter to understand a situation here and now, or, at least, historicity would not impact the method of modeling. We analyze that it is not the case with concrete examples. Historicity forces a conceptual reconfiguration where equations no longer play a central role. We argue that all observations depend on objects defined by their historical origin instead of their relations as in physics. Therefore, we propose that biological variations and historicity come first, and regularities are constraints with limited validity in biology. Their proper theoretical and empirical use requires specific rationales.","internal_url":"https://www.academia.edu/43503048/Historicity_at_the_heart_of_biology","translated_internal_url":"","created_at":"2020-07-02T15:26:31.121-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":35159257,"work_id":43503048,"tagging_user_id":28744524,"tagged_user_id":null,"co_author_invite_id":4270246,"email":"m***l@univ-paris1.fr","display_order":1,"name":"Maël Montévil","title":"Historicity at the heart of biology"}],"downloadable_attachments":[{"id":63812968,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63812968/thumbnails/1.jpg","file_name":"historicity20200702-15874-129q8l7.pdf","download_url":"https://www.academia.edu/attachments/63812968/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Historicity_at_the_heart_of_biology.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63812968/historicity20200702-15874-129q8l7-libre.pdf?1593729341=\u0026response-content-disposition=attachment%3B+filename%3DHistoricity_at_the_heart_of_biology.pdf\u0026Expires=1732359830\u0026Signature=clZwrsE14wYJg5H5QJ2LaIltiGyMLtYS7yb7k9It59lxgpLiBeyoHNgQRps11XA2tHfz~IUpcWj8YilIt2pd9zbMwjKXDFsgFuhitAHx4IOpeyln1iPhUwLwMK2m0W2gflVoLWiiPf9evdA7cE7GX4vJTCxeSue5t-CUoQ0c9mARH9IjrhqGTrgozXRupsiGSlIwRmKR-0Z6pKm-~HMV~GXH1ACG9rXboPxW4Ucg-EyPK-KCeEoIYMPsM9wGGFDJoLwn9sFYRZqNTnYMl3Ch3C4JtavGTc8dXO-w~cPZE4eEJiTR5cPx5s-bMc9hmGNR0ieuStGtHZvsc-9-tsMsiA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Historicity_at_the_heart_of_biology","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[{"id":63812968,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63812968/thumbnails/1.jpg","file_name":"historicity20200702-15874-129q8l7.pdf","download_url":"https://www.academia.edu/attachments/63812968/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Historicity_at_the_heart_of_biology.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63812968/historicity20200702-15874-129q8l7-libre.pdf?1593729341=\u0026response-content-disposition=attachment%3B+filename%3DHistoricity_at_the_heart_of_biology.pdf\u0026Expires=1732359830\u0026Signature=clZwrsE14wYJg5H5QJ2LaIltiGyMLtYS7yb7k9It59lxgpLiBeyoHNgQRps11XA2tHfz~IUpcWj8YilIt2pd9zbMwjKXDFsgFuhitAHx4IOpeyln1iPhUwLwMK2m0W2gflVoLWiiPf9evdA7cE7GX4vJTCxeSue5t-CUoQ0c9mARH9IjrhqGTrgozXRupsiGSlIwRmKR-0Z6pKm-~HMV~GXH1ACG9rXboPxW4Ucg-EyPK-KCeEoIYMPsM9wGGFDJoLwn9sFYRZqNTnYMl3Ch3C4JtavGTc8dXO-w~cPZE4eEJiTR5cPx5s-bMc9hmGNR0ieuStGtHZvsc-9-tsMsiA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":155,"name":"Evolutionary Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology"},{"id":502,"name":"Biophysics","url":"https://www.academia.edu/Documents/in/Biophysics"},{"id":821,"name":"Philosophy of Science","url":"https://www.academia.edu/Documents/in/Philosophy_of_Science"},{"id":823,"name":"Philosophy of Biology","url":"https://www.academia.edu/Documents/in/Philosophy_of_Biology"},{"id":1074,"name":"Organizational Theory","url":"https://www.academia.edu/Documents/in/Organizational_Theory"},{"id":8988,"name":"Instrumentation and Measurement Science","url":"https://www.academia.edu/Documents/in/Instrumentation_and_Measurement_Science"},{"id":16682,"name":"Mathematical Modelling","url":"https://www.academia.edu/Documents/in/Mathematical_Modelling"},{"id":24124,"name":"Morphogenesis","url":"https://www.academia.edu/Documents/in/Morphogenesis"},{"id":42465,"name":"Organizational Development","url":"https://www.academia.edu/Documents/in/Organizational_Development"},{"id":54023,"name":"Fine-Tuning","url":"https://www.academia.edu/Documents/in/Fine-Tuning"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43409703"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/43409703/The_Identity_of_Organisms_in_Scientific_Practice_Integrating_Historical_and_Relational_Conceptions"><img alt="Research paper thumbnail of The Identity of Organisms in Scientific Practice: Integrating Historical and Relational Conceptions" class="work-thumbnail" src="https://attachments.academia-assets.com/63709483/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/43409703/The_Identity_of_Organisms_in_Scientific_Practice_Integrating_Historical_and_Relational_Conceptions">The Identity of Organisms in Scientific Practice: Integrating Historical and Relational Conceptions</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://cnrs.academia.edu/MatteoMossio">Matteo Mossio</a></span></div><div class="wp-workCard_item"><span>Frontiers in physiology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We address the identity of biological organisms at play in experimental and modeling practices. W...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We address the identity of biological organisms at play in experimental and modeling practices. We first examine the central tenets of two general conceptions, and we assess their respective strengths and weaknesses. The historical conception, on the one hand, characterizes organisms' identity by looking at their past, and specifically at their genealogical connection with a common ancestor. The relational conception, on the other hand, interprets organisms' identity by referring to a set of distinctive relations between their parts, and between the organism and its environment. While the historical and relational conceptions are understood as opposed and conflicting, we submit that they are also fundamentally complementary. Accordingly, we put forward a hybrid conception, in which historical and relational (and more specifically, organizational) aspects of organisms' identity sustain and justify each other. Moreover, we argue that organisms' identity is not only hybrid but also bounded, insofar as the compliance with specific identity criteria tends to vanish as time passes, especially across generations. We spell out the core conceptual framework of this conception, and we outline an original formal representation. We contend that the hybrid and bounded conception of organisms' identity suits the epistemological needs of biological practices, particularly with regards to the generalization and reproducibility of experimental results, and the integration of mathematical models with experiments.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="71d0e745be6282b446daee399fdab2b7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63709483,"asset_id":43409703,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63709483/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43409703"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43409703"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43409703; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43409703]").text(description); $(".js-view-count[data-work-id=43409703]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43409703; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43409703']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 43409703, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "71d0e745be6282b446daee399fdab2b7" } } $('.js-work-strip[data-work-id=43409703]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43409703,"title":"The Identity of Organisms in Scientific Practice: Integrating Historical and Relational Conceptions","translated_title":"","metadata":{"doi":"10.3389/fphys.2020.00611","abstract":"We address the identity of biological organisms at play in experimental and modeling practices. We first examine the central tenets of two general conceptions, and we assess their respective strengths and weaknesses. The historical conception, on the one hand, characterizes organisms' identity by looking at their past, and specifically at their genealogical connection with a common ancestor. The relational conception, on the other hand, interprets organisms' identity by referring to a set of distinctive relations between their parts, and between the organism and its environment. While the historical and relational conceptions are understood as opposed and conflicting, we submit that they are also fundamentally complementary. Accordingly, we put forward a hybrid conception, in which historical and relational (and more specifically, organizational) aspects of organisms' identity sustain and justify each other. Moreover, we argue that organisms' identity is not only hybrid but also bounded, insofar as the compliance with specific identity criteria tends to vanish as time passes, especially across generations. We spell out the core conceptual framework of this conception, and we outline an original formal representation. We contend that the hybrid and bounded conception of organisms' identity suits the epistemological needs of biological practices, particularly with regards to the generalization and reproducibility of experimental results, and the integration of mathematical models with experiments.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Frontiers in physiology"},"translated_abstract":"We address the identity of biological organisms at play in experimental and modeling practices. We first examine the central tenets of two general conceptions, and we assess their respective strengths and weaknesses. The historical conception, on the one hand, characterizes organisms' identity by looking at their past, and specifically at their genealogical connection with a common ancestor. The relational conception, on the other hand, interprets organisms' identity by referring to a set of distinctive relations between their parts, and between the organism and its environment. While the historical and relational conceptions are understood as opposed and conflicting, we submit that they are also fundamentally complementary. Accordingly, we put forward a hybrid conception, in which historical and relational (and more specifically, organizational) aspects of organisms' identity sustain and justify each other. Moreover, we argue that organisms' identity is not only hybrid but also bounded, insofar as the compliance with specific identity criteria tends to vanish as time passes, especially across generations. We spell out the core conceptual framework of this conception, and we outline an original formal representation. We contend that the hybrid and bounded conception of organisms' identity suits the epistemological needs of biological practices, particularly with regards to the generalization and reproducibility of experimental results, and the integration of mathematical models with experiments.","internal_url":"https://www.academia.edu/43409703/The_Identity_of_Organisms_in_Scientific_Practice_Integrating_Historical_and_Relational_Conceptions","translated_internal_url":"","created_at":"2020-06-22T15:05:43.673-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":35071270,"work_id":43409703,"tagging_user_id":28744524,"tagged_user_id":235670,"co_author_invite_id":null,"email":"m***o@univ-paris1.fr","affiliation":"Centre National de la Recherche Scientifique / French National Centre for Scientific Research","display_order":1,"name":"Matteo Mossio","title":"The Identity of Organisms in Scientific Practice: Integrating Historical and Relational Conceptions"}],"downloadable_attachments":[{"id":63709483,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63709483/thumbnails/1.jpg","file_name":"fphys-11-0061120200622-105744-1u0eb8h.pdf","download_url":"https://www.academia.edu/attachments/63709483/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Identity_of_Organisms_in_Scientific.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63709483/fphys-11-0061120200622-105744-1u0eb8h-libre.pdf?1592864278=\u0026response-content-disposition=attachment%3B+filename%3DThe_Identity_of_Organisms_in_Scientific.pdf\u0026Expires=1732221638\u0026Signature=CSnWcDa4ZnQEliSJuKj3iw9Vrse7dEMpm3Hp1GUPbOhhkmDn5EACYJWcS-iUPpZyRWzG11JLe5DbG-v9aflBqVdEAw-iJp6qoBUmOWIfKuals30NnyOOhgFyp9~jCNhLrtEWlADxR51x9FYyTx~mrFNhgL1X0nq94cY00PiWVkaWc16lvjbWP~IQAfUSUVsJBI8Uz8r~q6U3F4-YzvRLNy7J1HEb9UyIa7fjmDUfjXurt97o-5B0~8XISBII6rbuIT~MQ1qlJJtnV5VQAXTMgLS9lF~fw~TdfCbRY5X4BsA~bTfemd2zMtHIR1U9NtOENP3BbE1FwJcgSoMB9l-b-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Identity_of_Organisms_in_Scientific_Practice_Integrating_Historical_and_Relational_Conceptions","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[{"id":63709483,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63709483/thumbnails/1.jpg","file_name":"fphys-11-0061120200622-105744-1u0eb8h.pdf","download_url":"https://www.academia.edu/attachments/63709483/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Identity_of_Organisms_in_Scientific.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63709483/fphys-11-0061120200622-105744-1u0eb8h-libre.pdf?1592864278=\u0026response-content-disposition=attachment%3B+filename%3DThe_Identity_of_Organisms_in_Scientific.pdf\u0026Expires=1732221638\u0026Signature=CSnWcDa4ZnQEliSJuKj3iw9Vrse7dEMpm3Hp1GUPbOhhkmDn5EACYJWcS-iUPpZyRWzG11JLe5DbG-v9aflBqVdEAw-iJp6qoBUmOWIfKuals30NnyOOhgFyp9~jCNhLrtEWlADxR51x9FYyTx~mrFNhgL1X0nq94cY00PiWVkaWc16lvjbWP~IQAfUSUVsJBI8Uz8r~q6U3F4-YzvRLNy7J1HEb9UyIa7fjmDUfjXurt97o-5B0~8XISBII6rbuIT~MQ1qlJJtnV5VQAXTMgLS9lF~fw~TdfCbRY5X4BsA~bTfemd2zMtHIR1U9NtOENP3BbE1FwJcgSoMB9l-b-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":155,"name":"Evolutionary Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology"},{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology"},{"id":821,"name":"Philosophy of Science","url":"https://www.academia.edu/Documents/in/Philosophy_of_Science"},{"id":823,"name":"Philosophy of Biology","url":"https://www.academia.edu/Documents/in/Philosophy_of_Biology"},{"id":972,"name":"Self and Identity","url":"https://www.academia.edu/Documents/in/Self_and_Identity"},{"id":1324,"name":"Organizational Change","url":"https://www.academia.edu/Documents/in/Organizational_Change"},{"id":2061,"name":"Genealogy","url":"https://www.academia.edu/Documents/in/Genealogy"},{"id":6288,"name":"Measurement and Evaluation","url":"https://www.academia.edu/Documents/in/Measurement_and_Evaluation"},{"id":16682,"name":"Mathematical Modelling","url":"https://www.academia.edu/Documents/in/Mathematical_Modelling"},{"id":26977,"name":"Theoretical biology","url":"https://www.academia.edu/Documents/in/Theoretical_biology"},{"id":37870,"name":"Organismal Biology","url":"https://www.academia.edu/Documents/in/Organismal_Biology"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43137804"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/43137804/A_Combined_Morphometric_and_Statistical_Approach_to_Assess_Nonmonotonicity_in_the_Developing_Mammary_Gland_of_Rats_in_the_CLARITY_BPA_Study"><img alt="Research paper thumbnail of A Combined Morphometric and Statistical Approach to Assess Nonmonotonicity in the Developing Mammary Gland of Rats in the CLARITY-BPA Study" class="work-thumbnail" src="https://attachments.academia-assets.com/63396940/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/43137804/A_Combined_Morphometric_and_Statistical_Approach_to_Assess_Nonmonotonicity_in_the_Developing_Mammary_Gland_of_Rats_in_the_CLARITY_BPA_Study">A Combined Morphometric and Statistical Approach to Assess Nonmonotonicity in the Developing Mammary Gland of Rats in the CLARITY-BPA Study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://tufts.academia.edu/AnaMSoto">Ana M Soto</a></span></div><div class="wp-workCard_item"><span>Environmental Health Perspectives</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND: The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND: The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES: We aimed to a) determine whether BPA showed effects on the developing rat mammary gland using new quantitative and established semiquantitative methods in two laboratories, b) develop a software tool for automatic evaluation of quantifiable aspects of the mammary ductal tree, and c) compare those methods. METHODS: Sprague-Dawley rats were exposed to BPA, vehicle, or positive control [ethinyl estradiol (EE2)] by oral gavage beginning on gestational day (GD)6 and continuing with direct dosing of the pups after birth. There were two studies: subchronic and chronic. The latter used two exposure regimes, one stopping at postnatal day (PND)21 (stop-dose) the other continuing until tissue harvest (continuous). Glands were harvested at multiple time points; whole mounts and histological specimens were analyzed blinded to treatment. RESULTS: The subchronic study's semiquantitative analysis revealed no significant differences between control and BPA dose groups at PND21, whereas at PND90 there were significant differences between control and the lowest BPA dose and between control and the lowest EE2 dose in animals in estrus. Quantitative, automatized analysis of the chronic PND21 specimens displayed nonmonotonic BPA effects, with a breaking point between the 25 and 250 lg=kg body weight (BW) per day doses. This breaking point was confirmed by a global statistical analysis of chronic study animals at PND90 and 6 months analyzed by the quantitative method. The BPA response was different from the EE2 effect for many features. CONCLUSIONS: Both the semiquantitative and the quantitative methods revealed nonmonotonic effects of BPA. The quantitative unsupervised analysis used 91 measurements and produced the most striking nonmonotonic dose-response curves. At all time points, lower doses resulted in larger effects, consistent with the core study, which revealed a significant increase of mammary adenocarcinoma incidence in the stop-dose animals at the lowest BPA dose tested.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ebfc76ff7cbfffce083eb496e6328f77" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63396940,"asset_id":43137804,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63396940/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43137804"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43137804"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43137804; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43137804]").text(description); $(".js-view-count[data-work-id=43137804]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43137804; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43137804']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 43137804, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ebfc76ff7cbfffce083eb496e6328f77" } } $('.js-work-strip[data-work-id=43137804]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43137804,"title":"A Combined Morphometric and Statistical Approach to Assess Nonmonotonicity in the Developing Mammary Gland of Rats in the CLARITY-BPA Study","translated_title":"","metadata":{"doi":"10.1289/EHP6301","abstract":"BACKGROUND: The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES: We aimed to a) determine whether BPA showed effects on the developing rat mammary gland using new quantitative and established semiquantitative methods in two laboratories, b) develop a software tool for automatic evaluation of quantifiable aspects of the mammary ductal tree, and c) compare those methods. METHODS: Sprague-Dawley rats were exposed to BPA, vehicle, or positive control [ethinyl estradiol (EE2)] by oral gavage beginning on gestational day (GD)6 and continuing with direct dosing of the pups after birth. There were two studies: subchronic and chronic. The latter used two exposure regimes, one stopping at postnatal day (PND)21 (stop-dose) the other continuing until tissue harvest (continuous). Glands were harvested at multiple time points; whole mounts and histological specimens were analyzed blinded to treatment. RESULTS: The subchronic study's semiquantitative analysis revealed no significant differences between control and BPA dose groups at PND21, whereas at PND90 there were significant differences between control and the lowest BPA dose and between control and the lowest EE2 dose in animals in estrus. Quantitative, automatized analysis of the chronic PND21 specimens displayed nonmonotonic BPA effects, with a breaking point between the 25 and 250 lg=kg body weight (BW) per day doses. This breaking point was confirmed by a global statistical analysis of chronic study animals at PND90 and 6 months analyzed by the quantitative method. The BPA response was different from the EE2 effect for many features. CONCLUSIONS: Both the semiquantitative and the quantitative methods revealed nonmonotonic effects of BPA. The quantitative unsupervised analysis used 91 measurements and produced the most striking nonmonotonic dose-response curves. At all time points, lower doses resulted in larger effects, consistent with the core study, which revealed a significant increase of mammary adenocarcinoma incidence in the stop-dose animals at the lowest BPA dose tested. ","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Environmental Health Perspectives"},"translated_abstract":"BACKGROUND: The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES: We aimed to a) determine whether BPA showed effects on the developing rat mammary gland using new quantitative and established semiquantitative methods in two laboratories, b) develop a software tool for automatic evaluation of quantifiable aspects of the mammary ductal tree, and c) compare those methods. METHODS: Sprague-Dawley rats were exposed to BPA, vehicle, or positive control [ethinyl estradiol (EE2)] by oral gavage beginning on gestational day (GD)6 and continuing with direct dosing of the pups after birth. There were two studies: subchronic and chronic. The latter used two exposure regimes, one stopping at postnatal day (PND)21 (stop-dose) the other continuing until tissue harvest (continuous). Glands were harvested at multiple time points; whole mounts and histological specimens were analyzed blinded to treatment. RESULTS: The subchronic study's semiquantitative analysis revealed no significant differences between control and BPA dose groups at PND21, whereas at PND90 there were significant differences between control and the lowest BPA dose and between control and the lowest EE2 dose in animals in estrus. Quantitative, automatized analysis of the chronic PND21 specimens displayed nonmonotonic BPA effects, with a breaking point between the 25 and 250 lg=kg body weight (BW) per day doses. This breaking point was confirmed by a global statistical analysis of chronic study animals at PND90 and 6 months analyzed by the quantitative method. The BPA response was different from the EE2 effect for many features. CONCLUSIONS: Both the semiquantitative and the quantitative methods revealed nonmonotonic effects of BPA. The quantitative unsupervised analysis used 91 measurements and produced the most striking nonmonotonic dose-response curves. At all time points, lower doses resulted in larger effects, consistent with the core study, which revealed a significant increase of mammary adenocarcinoma incidence in the stop-dose animals at the lowest BPA dose tested. 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href="https://www.academia.edu/40232744/Which_first_principles_for_mathematical_modelling_in_biology"><img alt="Research paper thumbnail of Which first principles for mathematical modelling in biology" class="work-thumbnail" src="https://attachments.academia-assets.com/60463460/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/40232744/Which_first_principles_for_mathematical_modelling_in_biology">Which first principles for mathematical modelling in biology</a></div><div class="wp-workCard_item"><span>Rendiconti di Matematica e delle sue Applicazioni</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Like theoretical physics, theoretical biology is not just mathematical modeling. Instead, theoret...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Like theoretical physics, theoretical biology is not just mathematical modeling. Instead, theoretical biology should strive to find suitable first principles to ground the understanding of biological phenomena and ultimately frame biological experiments and mathematical models. First principles in physics are expressed in terms of symmetries and the associated conservations, on the one side, and optimization on the other side. In biology, we argue instead that a strong notion of variation is fundamental. This notion encompasses new possibilities and the historicity of biological phenomena. By contrast, the relative regularity of some aspects of biological organisms, which we call constraints, should be regarded as the consequence of a mutual stabilization of the parts of organisms. We exemplify several aspects of this framework with the modeling of allometric relationships. Our change of perspective leads to reconsider the meaning of measurements and the structure of the space of description.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2fa5ce5891169d127b7e33ca881a9615" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":60463460,"asset_id":40232744,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/60463460/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="40232744"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="40232744"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 40232744; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=40232744]").text(description); $(".js-view-count[data-work-id=40232744]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 40232744; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='40232744']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 40232744, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2fa5ce5891169d127b7e33ca881a9615" } } $('.js-work-strip[data-work-id=40232744]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":40232744,"title":"Which first principles for mathematical modelling in biology","translated_title":"","metadata":{"abstract":"Like theoretical physics, theoretical biology is not just mathematical modeling. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="38904550"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/38904550/Measurement_in_biology_is_methodized_by_theory"><img alt="Research paper thumbnail of Measurement in biology is methodized by theory" class="work-thumbnail" src="https://attachments.academia-assets.com/59003420/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/38904550/Measurement_in_biology_is_methodized_by_theory">Measurement in biology is methodized by theory</a></div><div class="wp-workCard_item"><span>Biology & Philosophy</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We characterize access to empirical objects in biology from a theoretical perspective. Unlike obj...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We characterize access to empirical objects in biology from a theoretical perspective. Unlike objects in current physical theories, biological objects are the result of a history and their variations continue to generate a history. This property is the starting point of our concept of measurement. We argue that biological measurement is relative to a natural history which is shared by the different objects subjected to the measurement and is more or less constrained by biologists. We call symmetrization the theoretical and often concrete operation which leads to considering biological objects as equivalent in a measurement.  Last, we use our notion of measurement to analyze research strategies. Some strategies aim to bring biology closer to the epistemology of physical theories, by studying objects as similar as possible, while others build on biological diversity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="791c42a7e5b365e0e6ab745bf839a912" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":59003420,"asset_id":38904550,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/59003420/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="38904550"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="38904550"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 38904550; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=38904550]").text(description); $(".js-view-count[data-work-id=38904550]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 38904550; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='38904550']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 38904550, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "791c42a7e5b365e0e6ab745bf839a912" } } $('.js-work-strip[data-work-id=38904550]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":38904550,"title":"Measurement in biology is methodized by theory","translated_title":"","metadata":{"doi":"10.1007/s10539-019-9687-x","issue":"3","volume":"34","abstract":"We characterize access to empirical objects in biology from a theoretical perspective. 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href="https://www.academia.edu/35883104/Big_Data_and_Biological_Knowledge">Big Data and Biological Knowledge</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/GiuseppeLongo">Giuseppe Longo</a></span></div><div class="wp-workCard_item"><span>Predictability and the Unpredictable: Life, Evolution and Behaviour</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Some authors assert that the analysis of huge databases could replace the scientifc method. On th...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Some authors assert that the analysis of huge databases could replace the scientifc method. On the contrary, we argue that the best way to make these new technologies bear fruits is to frame them with theories concerning the phenomena of interest. Such theories hint to the observable that should be taken into account and the mathematical structures that may link them. In biology, we argue that the community urgently needs an overarching theory of organisms that would provide a precise framework to understand lifecycles. Among other benefts, such a theory should make explicit what we can and cannot predict in principle.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="11d2f43a7a81785b34ad62db607c8d30" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":56130026,"asset_id":35883104,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/56130026/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="35883104"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="35883104"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 35883104; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=35883104]").text(description); $(".js-view-count[data-work-id=35883104]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 35883104; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='35883104']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 35883104, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "11d2f43a7a81785b34ad62db607c8d30" } } $('.js-work-strip[data-work-id=35883104]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":35883104,"title":"Big Data and Biological Knowledge","translated_title":"","metadata":{"abstract":"Some authors assert that the analysis of huge databases could replace the scientifc method. 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href="https://www.academia.edu/33091779/A_primer_on_mathematical_modeling_in_the_study_of_organisms_and_their_parts"><img alt="Research paper thumbnail of A primer on mathematical modeling in the study of organisms and their parts" class="work-thumbnail" src="https://attachments.academia-assets.com/55164830/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/33091779/A_primer_on_mathematical_modeling_in_the_study_of_organisms_and_their_parts">A primer on mathematical modeling in the study of organisms and their parts</a></div><div class="wp-workCard_item"><span>Systems Biology.</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mathematical modeling is a very powerful tool to understand natural phenomena. Such a tool carrie...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mathematical modeling is a very powerful tool to understand natural phenomena. Such a tool carries its own assumptions and should always be used critically. In this chapter we highlight the key ingredients and steps of modeling and focus on their biological interpretation. In particular, we discuss the role of theoretical principles in writing models. We also highlight the meaning and interpretation of equations. The main aim of this chapter is to facilitate the interaction between biologists and mathematical modelers. We focus on the case of cell proliferation and motility in the context of multicellular organisms.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0b6e836bfe44bd458ffcab1bfd691a2b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":55164830,"asset_id":33091779,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/55164830/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="33091779"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="33091779"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33091779; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=33091779]").text(description); $(".js-view-count[data-work-id=33091779]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 33091779; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='33091779']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 33091779, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0b6e836bfe44bd458ffcab1bfd691a2b" } } $('.js-work-strip[data-work-id=33091779]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":33091779,"title":"A primer on mathematical modeling in the study of organisms and their parts","translated_title":"","metadata":{"doi":"10.1007/978-1-4939-7456-6_4","abstract":"Mathematical modeling is a very powerful tool to understand natural phenomena. 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}); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27624428"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27624428/Repetition_and_Reversibility_in_Evolution_Theoretical_Population_Genetics"><img alt="Research paper thumbnail of Repetition and Reversibility in Evolution: Theoretical Population Genetics" class="work-thumbnail" src="https://attachments.academia-assets.com/53062670/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27624428/Repetition_and_Reversibility_in_Evolution_Theoretical_Population_Genetics">Repetition and Reversibility in Evolution: Theoretical Population Genetics</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Repetitiveness and reversibility have long been considered as characteristic features of scientif...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Repetitiveness and reversibility have long been considered as characteristic features of scientific knowledge. In theoretical population genetics, repetitiveness is illustrated by a number of genetic equilibria realized under specific conditions. Since these equilibria are maintained despite a continual flux of changes in the course of generations (reshuffling of genes, reproduction…), it can legitimately be said that population genetics reveals important properties of invariance through transformation. Time-reversibility is a more controversial subject. Here, the parallel with classical mechanics is much weaker. Time-reversibility is unquestionable in some stochastic models, but at the cost of a special, probabilistic concept of reversibility. But it does not seem to be a property of the most basic deterministic models describing the dynamics of evolutionary change at the level of populations and genes. Furthermore, various meanings of ‘reversibility’ are distinguished. In particular, time-reversibility should not be confused with retrodictability.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ec0dac1c104e7e2b023383264759b736" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53062670,"asset_id":27624428,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53062670/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27624428"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27624428"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27624428; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27624428]").text(description); $(".js-view-count[data-work-id=27624428]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27624428; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27624428']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27624428, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ec0dac1c104e7e2b023383264759b736" } } $('.js-work-strip[data-work-id=27624428]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27624428,"title":"Repetition and Reversibility in Evolution: Theoretical Population Genetics","translated_title":"","metadata":{"abstract":"Repetitiveness and reversibility have long been considered as characteristic features of scientific knowledge. 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in knowledge construction. In this paper, we fi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Computer simulations brought remarkable novelties in knowledge construction. In this paper, we first distinguish between mathematical modeling, computer implementations of these models and purely computational approaches. In all three cases, different answers are provided to the questions the observer may have concerning the processes under in- vestigation. These differences will be highlighted by looking at the different theoretical symmetries of each frame. In the latter case, the peculiarities of Agent Based or Object Oriented Languages allow to discuss the role of phase spaces in mathematical analyses of physical vs. biological dynamics. Symmetry breaking and randomness are finally correlated in the various contexts where they may be observed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b9e08bb6eeb3d893d6797f99cd6fec4b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44147093,"asset_id":11720594,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44147093/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="11720594"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="11720594"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11720594; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11720594]").text(description); $(".js-view-count[data-work-id=11720594]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11720594; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='11720594']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 11720594, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b9e08bb6eeb3d893d6797f99cd6fec4b" } } $('.js-work-strip[data-work-id=11720594]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":11720594,"title":"Comparing Symmetries in Models and Simulations","translated_title":"","metadata":{"abstract":"Computer simulations brought remarkable novelties in knowledge construction. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="11720584"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/11720584/Scaling_and_Scale_Symmetries_in_Biological_Systems"><img alt="Research paper thumbnail of Scaling and Scale Symmetries in Biological Systems" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/11720584/Scaling_and_Scale_Symmetries_in_Biological_Systems">Scaling and Scale Symmetries in Biological Systems</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/GiuseppeLongo">Giuseppe Longo</a></span></div><div class="wp-workCard_item"><span>Lecture Notes in Morphogenesis</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="11720584"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="11720584"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11720584; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="11720591"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/11720591/Randomness_increases_order_in_biological_evolution"><img alt="Research paper thumbnail of Randomness increases order in biological evolution" class="work-thumbnail" src="https://attachments.academia-assets.com/43955384/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/11720591/Randomness_increases_order_in_biological_evolution">Randomness increases order in biological evolution</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/GiuseppeLongo">Giuseppe Longo</a></span></div><div class="wp-workCard_item"><span>Computation, Physics and Beyond, Lecture Notes in Computer Science</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this text, we revisit part of the analysis of anti-entropy in Bailly and Longo (2009) and deve...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this text, we revisit part of the analysis of anti-entropy in Bailly and<br />Longo (2009) and develop further theoretical reflections. In particular, we analyze<br />how randomness, an essential component of biological variability, is associated to<br />the growth of biological organization, both in ontogenesis and in evolution. This<br />approach, in particular, focuses on the role of global entropy production and pro-<br />vides a tool for a mathematical understanding of some fundamental observations<br />by Gould on the increasing phenotypic complexity along evolution. Lastly, we an-<br />alyze the situation in terms of theoretical symmetries, in order to further specify<br />the biological meaning of anti-entropy as well as its strong link with randomness.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fb304a048fdca179984440eb1b396417" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43955384,"asset_id":11720591,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43955384/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="11720591"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="11720591"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11720591; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11720591]").text(description); $(".js-view-count[data-work-id=11720591]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11720591; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='11720591']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 11720591, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fb304a048fdca179984440eb1b396417" } } $('.js-work-strip[data-work-id=11720591]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":11720591,"title":"Randomness increases order in biological evolution","translated_title":"","metadata":{"abstract":"In this text, we revisit part of the analysis of anti-entropy in Bailly and\nLongo (2009) and develop further theoretical reflections. 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class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/11720588/No_entailing_laws_but_enablement_in_the_evolution_of_the_biosphere">No entailing laws, but enablement in the evolution of the biosphere</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/GiuseppeLongo">Giuseppe Longo</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Biological evolution is a complex blend of ever changing structural stability, variability and em...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Biological evolution is a complex blend of ever changing structural stability, variability and emergence of new phenotypes, niches, ecosystems. We wish to argue that the evolution of life marks the end of a physics world view of law entailed dynamics. Our considerations depend upon discussing the variability of the very ''contexts of life'': the interactions between organisms, biological niches and ecosystems. These are ever changing, intrinsically indeterminate and even unprestatable: we do not know ahead of time the "niches" which constitute the boundary conditions on selection. More generally, by the mathematical unprestatability of the "phase space" (space of possibilities), no laws of motion can be formulated for evolution. We call this radical emergence, from life to life. The purpose of this paper is the integration of variation and diversity in a sound conceptual frame and situate unpredictability at a novel theoretical level, that of the very phase space. Our argument will be carried on in close comparisons with physics and the mathematical constructions of phase spaces in that discipline. The role of (theoretical) symmetries as invariant preserving transformations will allow us to understand the nature of physical phase spaces and to stress the differences required for a sound biological theoretizing. In this frame, we discuss the novel notion of ''enablement". Life lives in a web of enablement and radical emergence. This will restrict causal analyses to differential cases (a difference that causes a difference). Mutations or other causal differences will allow us to stress that ''non conservation principles" are at the core of evolution, in contrast to physical dynamics, largely based on conservation principles as symmetries. Critical transitions, the main locus of symmetry changes in physics, will be discussed, and lead to ''extended criticality" as a conceptual frame for a better understanding of the living state of matter.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="afd003a10253ec3e1abac07c7a4e6e6b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":40842851,"asset_id":11720588,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/40842851/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="11720588"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="11720588"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11720588; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11720588]").text(description); $(".js-view-count[data-work-id=11720588]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11720588; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='11720588']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 11720588, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "afd003a10253ec3e1abac07c7a4e6e6b" } } $('.js-work-strip[data-work-id=11720588]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":11720588,"title":"No entailing laws, but enablement in the evolution of the biosphere","translated_title":"","metadata":{"doi":"10.1145/2330784.2330946","abstract":"Biological evolution is a complex blend of ever changing structural stability, variability and emergence of new phenotypes, niches, ecosystems. 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class="work-thumbnail" src="https://attachments.academia-assets.com/66561412/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47501935/De_l_oeuvre_de_Turing_aux_d%C3%A9fis_contemporains_pour_la_compr%C3%A9hension_math%C3%A9matique_du_vivant">De l' oeuvre de Turing aux défis contemporains pour la compréhension mathématique du vivant</a></div><div class="wp-workCard_item"><span>Intellectica</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Turing distingue soigneusement l'imitation de la modélisation d'un phénomène. Cette dernière vise...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Turing distingue soigneusement l'imitation de la modélisation d'un phénomène. Cette dernière vise à saisir la structure causale du phénomène étudié. En biologie, il n'y a cependant pas de cadre théorique bien établi pour encadrer la pratique de modélisation. Nous partons de l'articulation entre la compréhension du vivant et la thermodynamique, en particulier le second principe. Ceci nous conduira à expliciter les défis théoriques et épistémologiques pour la compréhension mathématique du vivant. En particulier, l'historicité du vivant est un défi rarement abordé explicitement dans ce domaine. Nous pensons que ce défi nécessite un renversement complet de l'épistémologie de la physique afin d'aborder de manière théoriquement précise les organismes vivants. Ce changement épistémologique est pertinent tant pour la pratique théorique que pour l'interprétation des protocoles et résultats expérimentaux.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0ac866becfb384ba4ddab8e642bb4426" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66561412,"asset_id":47501935,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66561412/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47501935"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47501935"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47501935; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47501935]").text(description); $(".js-view-count[data-work-id=47501935]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47501935; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47501935']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47501935, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0ac866becfb384ba4ddab8e642bb4426" } } $('.js-work-strip[data-work-id=47501935]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47501935,"title":"De l' oeuvre de Turing aux défis contemporains pour la compréhension mathématique du vivant","translated_title":"","metadata":{"abstract":"Turing distingue soigneusement l'imitation de la modélisation d'un phénomène. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="46911617"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/46911617/Sciences_et_entropoc%C3%A8ne"><img alt="Research paper thumbnail of Sciences et entropocène" class="work-thumbnail" src="https://attachments.academia-assets.com/66284160/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/46911617/Sciences_et_entropoc%C3%A8ne">Sciences et entropocène</a></div><div class="wp-workCard_item"><span>EcoRev’ </span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated"> En examinant le second tome de Qu’appelle-t-on panser (1), le théoricien de la biologie et épist...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">En examinant le second tome de Qu’appelle-t-on panser (1), le théoricien de la biologie et épistémologue Maël Montévil, qui a collaboré avec Bernard Stiegler à la fois sur des questions théoriques et sur des expérimentations territoriales, s’arrête sur le rôle des sciences dans l’Anthropocène pour souligner leur difficulté à penser cette ère et, ce faisant, à prendre soin des vivants, humains et non-humains, des techniques et des sciences elles-mêmes. Stiegler soulignait l’importance de la question de l’entropie, conduisant au concept d’entropocène. L’auteur introduit et illustre ce concept pour montrer sa pertinence d’un point de vue physique, biologique et social. Ce faisant, il insiste sur la parenté mais aussi sur les différences entre ces phénomènes. 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Allons directement à la citation de Bergson tirée de La Pensée et le Mouvant 2 . La question posée est : qu'est-ce que l'événement d'une symphonie et qu'est-ce que l'événement en général ? Je suis absolument d'accord avec ce que tu dis dans ce texte parfaitement clair et convaincant. J'ai moi-même travaillé sur la musique. C'est la musique qui sert de matrice à la phénoménologie du temps de Husserl. Elle est aussi le champ idéal pour étudier l'irréductible technicité de cette phénoménologie. Là plus que nulle part ailleurs, il faudrait parler de phénoménotechnique en élargissant la notion de Bachelard 3 . Si la mélodie d'où part Husserl n'est certes pas toute la musique, c'est déjà de la musique. Et un instrument de musique est un objet technique -un organe exosomatique -à faire du temps, au sens où il (co)produit avec le musicien (c'est-à-dire par l'agencement des organes endosomatiques avec l'organe exosomatique qu'il est pour le musicien) des bifurcations anti-anthropiques. Il « fait » du temps au sens où Bergson et toi le disent, et ce n'est pas n'importe quel temps. C'est un temps qui n'est pas soluble dans le devenir, parce qu'il y ouvre un avenir d'où il revient. Cette revenance, qui est celle d'un esprit du temps, donne lieu et fait événement en ce sens : elle donne lieu à un temps (c'est l'événement) qui ouvre un espace du nouveau. Cette localité est néguanthropique en cela qu'elle procède de ce qu'Aristote appelle une poïésis. La musique, c'est ce temps bien spécifique. Sa spécificité relève d'une problématique de la quasi-causalité et de la performativité (je parle évidemment ici de performativité au sens du philosophe John Austin dans Quand dire c'est faire 4 )","publication_name":"Links","grobid_abstract_attachment_id":59513555},"translated_abstract":null,"internal_url":"https://www.academia.edu/39370702/Entretien_sur_lentropie_le_vivant_et_la_technique_Deuxi%C3%A8me_partie","translated_internal_url":"","created_at":"2019-06-04T09:21:11.411-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":32674054,"work_id":39370702,"tagging_user_id":28744524,"tagged_user_id":32379167,"co_author_invite_id":null,"email":"s***d@wanadoo.fr","affiliation":"Université de Technologie de Compiègne","display_order":1,"name":"stiegler bernard","title":"Entretien sur l'entropie, le vivant et la technique : Deuxième partie"},{"id":32995309,"work_id":39370702,"tagging_user_id":28744524,"tagged_user_id":31923226,"co_author_invite_id":null,"email":"b***r@centrepompidou.fr","display_order":4194304,"name":"Bernard Stiegler","title":"Entretien sur l'entropie, le vivant et la technique : Deuxième partie"}],"downloadable_attachments":[{"id":59513555,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/59513555/thumbnails/1.jpg","file_name":"entretien_sur_lentropie_2-web20190604-80344-1030psi.pdf","download_url":"https://www.academia.edu/attachments/59513555/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Entretien_sur_lentropie_le_vivant_et_la.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/59513555/entretien_sur_lentropie_2-web20190604-80344-1030psi-libre.pdf?1559665495=\u0026response-content-disposition=attachment%3B+filename%3DEntretien_sur_lentropie_le_vivant_et_la.pdf\u0026Expires=1732359830\u0026Signature=KqrT553VsryG9R4gOBc-W9bRoA11PLyIlerh-YRF9MBts-OJ~IQkJ2Cbpx2avKUP~wVt6PYEzMfwenv~guwUH4oC1MdFddTCxwPxFCPjmcpJhRr1cEkp~P1S1YrpmHqx2s9OgXwGMQGy43Qkt8j1MlX158ktJOGbDyryeFgWjITwxwZ-Vz75XvMKp24xMeOOqQqHwnJjEoSO4QcVBL3w5n3qmD2JlWjDLiDlGZHDFaFTC12EREY0JcYOH6cezvF2e7oUP-cWqsOdBsSDV-twaHjW5O3msXUfvQttqxkdBcwPvzC5e1DzaS1WvFacJM6rTJuKIc2MMqipYDxUinKMiA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Entretien_sur_lentropie_le_vivant_et_la_technique_Deuxième_partie","translated_slug":"","page_count":8,"language":"fr","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[{"id":59513555,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/59513555/thumbnails/1.jpg","file_name":"entretien_sur_lentropie_2-web20190604-80344-1030psi.pdf","download_url":"https://www.academia.edu/attachments/59513555/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Entretien_sur_lentropie_le_vivant_et_la.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/59513555/entretien_sur_lentropie_2-web20190604-80344-1030psi-libre.pdf?1559665495=\u0026response-content-disposition=attachment%3B+filename%3DEntretien_sur_lentropie_le_vivant_et_la.pdf\u0026Expires=1732359830\u0026Signature=KqrT553VsryG9R4gOBc-W9bRoA11PLyIlerh-YRF9MBts-OJ~IQkJ2Cbpx2avKUP~wVt6PYEzMfwenv~guwUH4oC1MdFddTCxwPxFCPjmcpJhRr1cEkp~P1S1YrpmHqx2s9OgXwGMQGy43Qkt8j1MlX158ktJOGbDyryeFgWjITwxwZ-Vz75XvMKp24xMeOOqQqHwnJjEoSO4QcVBL3w5n3qmD2JlWjDLiDlGZHDFaFTC12EREY0JcYOH6cezvF2e7oUP-cWqsOdBsSDV-twaHjW5O3msXUfvQttqxkdBcwPvzC5e1DzaS1WvFacJM6rTJuKIc2MMqipYDxUinKMiA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":803,"name":"Philosophy","url":"https://www.academia.edu/Documents/in/Philosophy"},{"id":821,"name":"Philosophy of Science","url":"https://www.academia.edu/Documents/in/Philosophy_of_Science"},{"id":823,"name":"Philosophy of Biology","url":"https://www.academia.edu/Documents/in/Philosophy_of_Biology"},{"id":855,"name":"Philosophy of Technology","url":"https://www.academia.edu/Documents/in/Philosophy_of_Technology"},{"id":923,"name":"Technology","url":"https://www.academia.edu/Documents/in/Technology"},{"id":6631,"name":"Economics of Innovation","url":"https://www.academia.edu/Documents/in/Economics_of_Innovation"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":36265,"name":"Entropy","url":"https://www.academia.edu/Documents/in/Entropy"}],"urls":[{"id":8781117,"url":"https://montevil.theobio.org/en/stiegler-montevil-entropie-vivant-technique-partie2"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37523252"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37523252/R%C3%A9p%C3%A9tition_et_R%C3%A9versibilit%C3%A9_dans_l%C3%89volution_La_g%C3%A9n%C3%A9tique_des_populations_th%C3%A9orique"><img alt="Research paper thumbnail of Répétition et Réversibilité dans l'Évolution: La génétique des populations théorique" class="work-thumbnail" src="https://attachments.academia-assets.com/57496544/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37523252/R%C3%A9p%C3%A9tition_et_R%C3%A9versibilit%C3%A9_dans_l%C3%89volution_La_g%C3%A9n%C3%A9tique_des_populations_th%C3%A9orique">Répétition et Réversibilité dans l'Évolution: La génétique des populations théorique</a></div><div class="wp-workCard_item"><span>Temps de la nature & nature du temps. Études philosophiques sur le temps dans les sciences naturelles.</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">La répétitivité et la réversibilité ont longtemps été considérées comme des traits caractéristiqu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">La répétitivité et la réversibilité ont longtemps été considérées comme des traits caractéristiques de la connaissance scientifique. Dans la génétique des populations, la répétitivité est illustrée par un certain nombre d'équilibres réalisés dans des conditions spécifiques. Étant donné que ces équilibres sont maintenus en dépit du renouvellement des générations (réarrangement de gènes, reproduction ...), on peut légitimement dire que la génétique des populations révèle d'importantes propriétés d'invariance par transformation. La réversibilité est un sujet plus controversé. Ici, le parallèle avec la mécanique classique est beaucoup plus faible. La réversibilité est incontestable dans certains modèles stochastiques, mais au prix d'un concept probabiliste particulier de réversibilité. Par contre, elle ne semble pas être une propriété de la plupart des modèles déterministes classiques décrivant la dynamique des changements évolutifs au niveau des populations. Nous distinguons plusieurs sens de la « réversibilité ». En particulier, la symétrie par inversion du temps ne doit pas être confondue avec la rétrodiction.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d70153c2e2e474ff5a57bfb02705e409" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57496544,"asset_id":37523252,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57496544/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37523252"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37523252"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37523252; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=37523252]").text(description); $(".js-view-count[data-work-id=37523252]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 37523252; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='37523252']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 37523252, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d70153c2e2e474ff5a57bfb02705e409" } } $('.js-work-strip[data-work-id=37523252]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":37523252,"title":"Répétition et Réversibilité dans l'Évolution: La génétique des populations théorique","translated_title":"","metadata":{"abstract":"La répétitivité et la réversibilité ont longtemps été considérées comme des traits caractéristiques de la connaissance scientifique. Dans la génétique des populations, la répétitivité est illustrée par un certain nombre d'équilibres réalisés dans des conditions spécifiques. Étant donné que ces équilibres sont maintenus en dépit du renouvellement des générations (réarrangement de gènes, reproduction ...), on peut légitimement dire que la génétique des populations révèle d'importantes propriétés d'invariance par transformation. La réversibilité est un sujet plus controversé. Ici, le parallèle avec la mécanique classique est beaucoup plus faible. La réversibilité est incontestable dans certains modèles stochastiques, mais au prix d'un concept probabiliste particulier de réversibilité. Par contre, elle ne semble pas être une propriété de la plupart des modèles déterministes classiques décrivant la dynamique des changements évolutifs au niveau des populations. Nous distinguons plusieurs sens de la « réversibilité ». En particulier, la symétrie par inversion du temps ne doit pas être confondue avec la rétrodiction.","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Temps de la nature \u0026 nature du temps. Études philosophiques sur le temps dans les sciences naturelles."},"translated_abstract":"La répétitivité et la réversibilité ont longtemps été considérées comme des traits caractéristiques de la connaissance scientifique. Dans la génétique des populations, la répétitivité est illustrée par un certain nombre d'équilibres réalisés dans des conditions spécifiques. Étant donné que ces équilibres sont maintenus en dépit du renouvellement des générations (réarrangement de gènes, reproduction ...), on peut légitimement dire que la génétique des populations révèle d'importantes propriétés d'invariance par transformation. La réversibilité est un sujet plus controversé. Ici, le parallèle avec la mécanique classique est beaucoup plus faible. La réversibilité est incontestable dans certains modèles stochastiques, mais au prix d'un concept probabiliste particulier de réversibilité. Par contre, elle ne semble pas être une propriété de la plupart des modèles déterministes classiques décrivant la dynamique des changements évolutifs au niveau des populations. Nous distinguons plusieurs sens de la « réversibilité ». En particulier, la symétrie par inversion du temps ne doit pas être confondue avec la rétrodiction.","internal_url":"https://www.academia.edu/37523252/R%C3%A9p%C3%A9tition_et_R%C3%A9versibilit%C3%A9_dans_l%C3%89volution_La_g%C3%A9n%C3%A9tique_des_populations_th%C3%A9orique","translated_internal_url":"","created_at":"2018-10-03T08:08:21.376-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":31926547,"work_id":37523252,"tagging_user_id":28744524,"tagged_user_id":17717194,"co_author_invite_id":null,"email":"j***n@gmail.com","affiliation":"Centre National de la Recherche Scientifique / French National Centre for Scientific Research","display_order":1,"name":"Jean Gayon","title":"Répétition et Réversibilité dans l'Évolution: La génétique des populations théorique"}],"downloadable_attachments":[{"id":57496544,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/57496544/thumbnails/1.jpg","file_name":"GayonMontevil-reversibilite.pdf","download_url":"https://www.academia.edu/attachments/57496544/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Repetition_et_Reversibilite_dans_lEvolut.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/57496544/GayonMontevil-reversibilite-libre.pdf?1538579603=\u0026response-content-disposition=attachment%3B+filename%3DRepetition_et_Reversibilite_dans_lEvolut.pdf\u0026Expires=1732359830\u0026Signature=SDufSLHN-Vv38jF46vEujsvIdZU18xwATKA21WawamUJwcIG3DHnrY9iRr1ejLwFEKFcazoEBYRlj1~rJNeiViUndi52VJjLPBXy3vzLj7h~eyTuAhJUZGvx496~rvd~tg4mZcXt0-X4hGq53s4xqIu-qZm5mi2Cl6fzZcXJF7MyEKPuw4eTdyk0-lRBK7Aj2SCVZcvYvBwM4kQVFk56ya1ba68YkAu5PYoespQOCxmFEc7UWBSldDz1dHI2rlm12BB4w83vtdRtJNYbu9qwWQhyLUyeu~I36Snoiho8vLqe3MDh-BjWq~c5c9ZRDU1fRHTPTWObZvjar-4zQX9j6Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Répétition_et_Réversibilité_dans_lÉvolution_La_génétique_des_populations_théorique","translated_slug":"","page_count":25,"language":"fr","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[{"id":57496544,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/57496544/thumbnails/1.jpg","file_name":"GayonMontevil-reversibilite.pdf","download_url":"https://www.academia.edu/attachments/57496544/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Repetition_et_Reversibilite_dans_lEvolut.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/57496544/GayonMontevil-reversibilite-libre.pdf?1538579603=\u0026response-content-disposition=attachment%3B+filename%3DRepetition_et_Reversibilite_dans_lEvolut.pdf\u0026Expires=1732359831\u0026Signature=L3PoArhfr649hT1H9CZPrIosht58Kd0BnTu4RE29K6kssu1vnvMJNXSzGf~4d72O0T1gI-own2ePCGvymxU-o6S~Z7q7x0-sawnAt9vhOo7aJ9Rb31PlXh0ld3Wazh1VilfLcKF6ecLlCoE4z9tkuOCpQll3~27rtPYWGVaJo7hmuDa0KksHWWz0uTmgposyhh6lw5~hmtybpSyGcSnAjJoytjtL8gs0JHTfSUPULapy7xzLf2mgueH5D39QgcWoujeAivd9nSOnY3R~7qIXJi7pG~AbGTLNf03p5PovER~9hTLIrFpGiKZ5FD-VCr-a3BQhlnoY7uTtKdAHpqp-xw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":155,"name":"Evolutionary Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology"},{"id":4480,"name":"Population Genetics","url":"https://www.academia.edu/Documents/in/Population_Genetics"},{"id":14989,"name":"Philosophy of Time","url":"https://www.academia.edu/Documents/in/Philosophy_of_Time"}],"urls":[{"id":8781158,"url":"https://montevil.theobio.org/en/Gayon-Montevil-repetition-reversibilite-evolution"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="32926136"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/32926136/Du_si%C3%A8cle_du_g%C3%A8ne_%C3%A0_celui_de_lorganisme_introduction_%C3%A0_de_nouvelles_perspectives_th%C3%A9oriques"><img alt="Research paper thumbnail of Du siècle du gène à celui de l'organisme : introduction à de nouvelles perspectives théoriques" class="work-thumbnail" src="https://attachments.academia-assets.com/53060284/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/32926136/Du_si%C3%A8cle_du_g%C3%A8ne_%C3%A0_celui_de_lorganisme_introduction_%C3%A0_de_nouvelles_perspectives_th%C3%A9oriques">Du siècle du gène à celui de l'organisme : introduction à de nouvelles perspectives théoriques</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/GiuseppeLongo">Giuseppe Longo</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Les organismes, qu'ils soient uni ou multi-cellulaires, sont des agents capables de créer leurs p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Les organismes, qu'ils soient uni ou multi-cellulaires, sont des agents capables de créer leurs propres normes ; ils articulent continuellement leur capacité à créer de la nouveauté et de la stabilité, c'est-à-dire qu'ils combinent plasticité et robustesse. Ici, nous présentons et articulons brièvement les trois principes proposés récemment pour une théorie des organismes, à savoir : l'état par défaut, prolifération avec variation et motilité, le principe de variation et le principe d'organisation. Ces principes modifient profondément les observables biologiques et leur nature théorique par rapport aux cadres des théories physiques. Ce changement radical ouvre la possibilité d'ancrer la modélisation mathématique à des principes proprement biologiques.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a3b3d8a08a1f886959d0a21fae751a9b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53060284,"asset_id":32926136,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53060284/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="32926136"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="32926136"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 32926136; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=32926136]").text(description); $(".js-view-count[data-work-id=32926136]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 32926136; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='32926136']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 32926136, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a3b3d8a08a1f886959d0a21fae751a9b" } } $('.js-work-strip[data-work-id=32926136]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":32926136,"title":"Du siècle du gène à celui de l'organisme : introduction à de nouvelles perspectives théoriques","translated_title":"","metadata":{"abstract":"Les organismes, qu'ils soient uni ou multi-cellulaires, sont des agents capables de créer leurs propres normes ; ils articulent continuellement leur capacité à créer de la nouveauté et de la stabilité, c'est-à-dire qu'ils combinent plasticité et robustesse. Ici, nous présentons et articulons brièvement les trois principes proposés récemment pour une théorie des organismes, à savoir : l'état par défaut, prolifération avec variation et motilité, le principe de variation et le principe d'organisation. Ces principes modifient profondément les observables biologiques et leur nature théorique par rapport aux cadres des théories physiques. Ce changement radical ouvre la possibilité d'ancrer la modélisation mathématique à des principes proprement biologiques.","publication_date":{"day":null,"month":null,"year":2017,"errors":{}}},"translated_abstract":"Les organismes, qu'ils soient uni ou multi-cellulaires, sont des agents capables de créer leurs propres normes ; ils articulent continuellement leur capacité à créer de la nouveauté et de la stabilité, c'est-à-dire qu'ils combinent plasticité et robustesse. Ici, nous présentons et articulons brièvement les trois principes proposés récemment pour une théorie des organismes, à savoir : l'état par défaut, prolifération avec variation et motilité, le principe de variation et le principe d'organisation. Ces principes modifient profondément les observables biologiques et leur nature théorique par rapport aux cadres des théories physiques. Ce changement radical ouvre la possibilité d'ancrer la modélisation mathématique à des principes proprement biologiques.","internal_url":"https://www.academia.edu/32926136/Du_si%C3%A8cle_du_g%C3%A8ne_%C3%A0_celui_de_lorganisme_introduction_%C3%A0_de_nouvelles_perspectives_th%C3%A9oriques","translated_internal_url":"","created_at":"2017-05-09T11:36:30.775-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":28851105,"work_id":32926136,"tagging_user_id":28744524,"tagged_user_id":2771586,"co_author_invite_id":null,"email":"g***o@ens.fr","affiliation":"École Normale Supérieure","display_order":1,"name":"Giuseppe Longo","title":"Du siècle du gène à celui de l'organisme : introduction à de nouvelles perspectives théoriques"},{"id":28851106,"work_id":32926136,"tagging_user_id":28744524,"tagged_user_id":3435740,"co_author_invite_id":null,"email":"a***o@tufts.edu","affiliation":"Tufts University","display_order":2,"name":"Ana M Soto","title":"Du siècle du gène à celui de l'organisme : introduction à de nouvelles perspectives théoriques"}],"downloadable_attachments":[{"id":53060284,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53060284/thumbnails/1.jpg","file_name":"cerisy-theorieorganisme-final.pdf","download_url":"https://www.academia.edu/attachments/53060284/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Du_siecle_du_gene_a_celui_de_lorganisme.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53060284/cerisy-theorieorganisme-final-libre.pdf?1494355165=\u0026response-content-disposition=attachment%3B+filename%3DDu_siecle_du_gene_a_celui_de_lorganisme.pdf\u0026Expires=1732183898\u0026Signature=eJuPg9DkCLTyBhYHYfvTOvc5enTpQ~cyzOuLubYT4EFxNcBmwMH3uem2iR-EOMAuiIPxqxKY~oNWV33N0yZL1g0TxeDa3J-ZePaNRhMnBrAMLukEj7V30TP3jIoPLDQJi0Gk5U3hPVTAXLCAhegkDFYJStXFZyA5AA09xOPArdo97hB4BSqIkoIDNNFKxxZ1FqynY0UUfDo5hsHzTvO5tINl5YTtTq0wmUYgmi72jpCWsvnFji00KEsHdNeJxtkPbL23Fc5-uDrjaafpo5h8R3CA2JhcNkqiByqKO2DKfBooSly4VPAdvuhtsjC1Vs0YeRHnEFIEwobcsW4Gri7rdg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Du_siècle_du_gène_à_celui_de_lorganisme_introduction_à_de_nouvelles_perspectives_théoriques","translated_slug":"","page_count":17,"language":"fr","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[{"id":53060284,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53060284/thumbnails/1.jpg","file_name":"cerisy-theorieorganisme-final.pdf","download_url":"https://www.academia.edu/attachments/53060284/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Du_siecle_du_gene_a_celui_de_lorganisme.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53060284/cerisy-theorieorganisme-final-libre.pdf?1494355165=\u0026response-content-disposition=attachment%3B+filename%3DDu_siecle_du_gene_a_celui_de_lorganisme.pdf\u0026Expires=1732183898\u0026Signature=eJuPg9DkCLTyBhYHYfvTOvc5enTpQ~cyzOuLubYT4EFxNcBmwMH3uem2iR-EOMAuiIPxqxKY~oNWV33N0yZL1g0TxeDa3J-ZePaNRhMnBrAMLukEj7V30TP3jIoPLDQJi0Gk5U3hPVTAXLCAhegkDFYJStXFZyA5AA09xOPArdo97hB4BSqIkoIDNNFKxxZ1FqynY0UUfDo5hsHzTvO5tINl5YTtTq0wmUYgmi72jpCWsvnFji00KEsHdNeJxtkPbL23Fc5-uDrjaafpo5h8R3CA2JhcNkqiByqKO2DKfBooSly4VPAdvuhtsjC1Vs0YeRHnEFIEwobcsW4Gri7rdg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology"},{"id":823,"name":"Philosophy of Biology","url":"https://www.academia.edu/Documents/in/Philosophy_of_Biology"},{"id":1083,"name":"Developmental Biology","url":"https://www.academia.edu/Documents/in/Developmental_Biology"},{"id":1324,"name":"Organizational Change","url":"https://www.academia.edu/Documents/in/Organizational_Change"},{"id":7083,"name":"Autopoiesis","url":"https://www.academia.edu/Documents/in/Autopoiesis"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26977,"name":"Theoretical biology","url":"https://www.academia.edu/Documents/in/Theoretical_biology"},{"id":37870,"name":"Organismal Biology","url":"https://www.academia.edu/Documents/in/Organismal_Biology"},{"id":80561,"name":"Variability","url":"https://www.academia.edu/Documents/in/Variability"},{"id":987813,"name":"Basic Principles","url":"https://www.academia.edu/Documents/in/Basic_Principles"}],"urls":[{"id":8781159,"url":"https://montevil.theobio.org/en/siecle-gene-organisme-introduction-nouvelles-perspectives-theoriques"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="32926096"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/32926096/Big_Data_et_connaissance_biologique"><img alt="Research paper thumbnail of Big Data et connaissance biologique" class="work-thumbnail" src="https://attachments.academia-assets.com/53060239/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/32926096/Big_Data_et_connaissance_biologique">Big Data et connaissance biologique</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/GiuseppeLongo">Giuseppe Longo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Certains auteurs affirment que l'analyse des grandes bases de données pourrait remplacer la métho...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Certains auteurs affirment que l'analyse des grandes bases de données pourrait remplacer la méthode scientifique. A contrario, nous argumentons que la bonne manière de faire fructifier ces nouveautés techniques est de les encadrer théoriquement. En biologie, en particulier, il nous semble urgent de développer une théorie des organismes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2a8219b1dacc46ed8bbc0cf059187008" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53060239,"asset_id":32926096,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53060239/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="32926096"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="32926096"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 32926096; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=32926096]").text(description); $(".js-view-count[data-work-id=32926096]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 32926096; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='32926096']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 32926096, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2a8219b1dacc46ed8bbc0cf059187008" } } $('.js-work-strip[data-work-id=32926096]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":32926096,"title":"Big Data et connaissance biologique","translated_title":"","metadata":{"abstract":"Certains auteurs affirment que l'analyse des grandes bases de données pourrait remplacer la méthode scientifique. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30241203"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30241203/Changements_de_sym%C3%A9trie_criticit%C3%A9_et_al%C3%A9atoire_Math%C3%A9matiques_et_objectivation_du_vivant"><img alt="Research paper thumbnail of Changements de symétrie, criticité et aléatoire : Mathématiques et objectivation du vivant" class="work-thumbnail" src="https://attachments.academia-assets.com/50705736/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30241203/Changements_de_sym%C3%A9trie_criticit%C3%A9_et_al%C3%A9atoire_Math%C3%A9matiques_et_objectivation_du_vivant">Changements de symétrie, criticité et aléatoire : Mathématiques et objectivation du vivant</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ce texte présente un modèle pour le temps biologique ainsi qu'un certain nombre d'idées plus géné...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ce texte présente un modèle pour le temps biologique ainsi qu'un certain nombre d'idées plus générales sur l'articulation entre mathématiques et objets biologiques, fondées sur des propositions théoriques. Nous décrivons d'abord un modèle géométrisant le temps des mammifères, basé en partie sur la notion d'allométrie. Ce modèle permet de mettre en évidence la structure de la variabilité des rythmes biologiques et de discriminer cas sains et cas pathologiques. Nous utilisons cet exemple pour illustrer les principes permettant la mathématisation. Nous discutons comment s'articulent mathématiques et définition théorique des objets physiques. Nous mettons en particulier l'accent sur le rôle que jouent les symétries théoriques pour justifier ces définitions, tant au niveau de la constitution d'un espace de description que de l'obtention d'équations déterminant la trajectoire suivie par un objet. Nous abordons aussi les transitions de phases comme situations paradigmatiques où les symétries d'un système changent. Ceci nous amène à proposer que les objets biologiques (organismes, cellules) sont caractérisés par une instabilité de leurs symétries théoriques. Les objets prennent alors un sens différent de celui qu'ils ont en physique : ils font preuve de variabilité et sont fondamentalement historiques. Ceci n'empêche pas la présence d’éléments de stabilité chez le vivant, mais les symétries biologiques prennent un sens différent des symétries fondamentales de la physique.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c7949ff7882615ac14f58e247e5f4997" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50705736,"asset_id":30241203,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50705736/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30241203"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30241203"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30241203; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30241203]").text(description); $(".js-view-count[data-work-id=30241203]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30241203; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30241203']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30241203, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c7949ff7882615ac14f58e247e5f4997" } } $('.js-work-strip[data-work-id=30241203]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30241203,"title":"Changements de symétrie, criticité et aléatoire : Mathématiques et objectivation du vivant","translated_title":"","metadata":{"abstract":"Ce texte présente un modèle pour le temps biologique ainsi qu'un certain nombre d'idées plus générales sur l'articulation entre mathématiques et objets biologiques, fondées sur des propositions théoriques. Nous décrivons d'abord un modèle géométrisant le temps des mammifères, basé en partie sur la notion d'allométrie. Ce modèle permet de mettre en évidence la structure de la variabilité des rythmes biologiques et de discriminer cas sains et cas pathologiques. Nous utilisons cet exemple pour illustrer les principes permettant la mathématisation. Nous discutons comment s'articulent mathématiques et définition théorique des objets physiques. Nous mettons en particulier l'accent sur le rôle que jouent les symétries théoriques pour justifier ces définitions, tant au niveau de la constitution d'un espace de description que de l'obtention d'équations déterminant la trajectoire suivie par un objet. Nous abordons aussi les transitions de phases comme situations paradigmatiques où les symétries d'un système changent. Ceci nous amène à proposer que les objets biologiques (organismes, cellules) sont caractérisés par une instabilité de leurs symétries théoriques. Les objets prennent alors un sens différent de celui qu'ils ont en physique : ils font preuve de variabilité et sont fondamentalement historiques. Ceci n'empêche pas la présence d’éléments de stabilité chez le vivant, mais les symétries biologiques prennent un sens différent des symétries fondamentales de la physique.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"Ce texte présente un modèle pour le temps biologique ainsi qu'un certain nombre d'idées plus générales sur l'articulation entre mathématiques et objets biologiques, fondées sur des propositions théoriques. Nous décrivons d'abord un modèle géométrisant le temps des mammifères, basé en partie sur la notion d'allométrie. Ce modèle permet de mettre en évidence la structure de la variabilité des rythmes biologiques et de discriminer cas sains et cas pathologiques. Nous utilisons cet exemple pour illustrer les principes permettant la mathématisation. Nous discutons comment s'articulent mathématiques et définition théorique des objets physiques. Nous mettons en particulier l'accent sur le rôle que jouent les symétries théoriques pour justifier ces définitions, tant au niveau de la constitution d'un espace de description que de l'obtention d'équations déterminant la trajectoire suivie par un objet. Nous abordons aussi les transitions de phases comme situations paradigmatiques où les symétries d'un système changent. Ceci nous amène à proposer que les objets biologiques (organismes, cellules) sont caractérisés par une instabilité de leurs symétries théoriques. Les objets prennent alors un sens différent de celui qu'ils ont en physique : ils font preuve de variabilité et sont fondamentalement historiques. 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data-click-track="profile-work-strip-title" href="https://www.academia.edu/9642725/Lincompressible_complexit%C3%A9_du_r%C3%A9el_et_la_construction_%C3%A9volutive_du_simple">L'incompressible complexité du réel et la construction évolutive du simple</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/GiuseppeLongo">Giuseppe Longo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://cnrs.academia.edu/ArnaudPocheville">Arnaud Pocheville</a></span></div><div class="wp-workCard_item"><span>Autour de la Simplexité</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">En parcourant un fil conducteur de l’évolution darwinienne, on trouve çà et là la formation du si...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">En parcourant un fil conducteur de l’évolution darwinienne, on trouve çà et là la formation du simple, comme résultat de la complexité des trajectoires évolutives : par exemple, la variété, la richesse, la … complexité des Bauplan de la faune de Burgess et Ediacara (Gould, 1989) s’est transformée en la « simplicité » des Bauplan qui suivront, et de l’activité qu’ils rendent possible. Tout en prolongeant l’évolution des espèces, l’évolution de l’homme, jusqu’à son histoire, paraît aussi fournir, çà et là, des éléments de cette simplification qui choisit, transforme, organise l’action dans le monde, dont nous parlerons. On pourrait alors donner un sens historique à la notion de simplexité dans (Berthoz, 2009) : <br /> <br />– c’est le simple qui résulte d’une histoire complexe, <br /> <br />– du simple qui n’est jamais élémentaire (atomique, irréductible). <br /> <br />En physique, cette histoire peut être remplacée par une dynamique de modèles mathématiques qui aide à passer d’un système d’interactions locales, très complexe, à une situation globale, relativement plus simple, limite de la dynamique considérée. Ces dynamiques permettent de traiter les transitions critiques. Dans ce cas aussi, mais de façon fortement mathématisée, l’intégration globale de réseaux localement intelligibles, mais trop riches pour être saisis comme un tout, peut proposer un autre exemple de simplexité, plus technique, un exemple qui trouve son sens à la limite asymptotique. Les méthodes de renormalisation, auxquelles nous ferons informellement référence, en donnent un aperçu de grande puissance physico-mathématique. Nous considérons le passage de l’analyse mathématique de la criticité physique à l’analyse du biologique, en tant que situation critique étendue, une transition conceptuelle possible de la théorisation physique à celle de l’état vivant de la matière.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="594a1275b4510f762b7798ac5f7f8625" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":35843336,"asset_id":9642725,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/35843336/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="9642725"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="9642725"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 9642725; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=9642725]").text(description); $(".js-view-count[data-work-id=9642725]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 9642725; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='9642725']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 9642725, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "594a1275b4510f762b7798ac5f7f8625" } } $('.js-work-strip[data-work-id=9642725]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":9642725,"title":"L'incompressible complexité du réel et la construction évolutive du simple","translated_title":"","metadata":{"abstract":"En parcourant un fil conducteur de l’évolution darwinienne, on trouve çà et là la formation du simple, comme résultat de la complexité des trajectoires évolutives : par exemple, la variété, la richesse, la … complexité des Bauplan de la faune de Burgess et Ediacara (Gould, 1989) s’est transformée en la « simplicité » des Bauplan qui suivront, et de l’activité qu’ils rendent possible. 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Construction, Autonomy and Original )</a></div><div class="wp-workCard_item"><span>Constructivist Foundations</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Upshot: I discuss convergences between the approach of the authors and my work aiming for a theor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Upshot: I discuss convergences between the approach of the authors and my work aiming for a theory of organisms. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="41183766"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/41183766/Commentaire_sur_Franck_Varenne_From_models_to_simulations"><img alt="Research paper thumbnail of Commentaire sur : Franck Varenne, From models to simulations" class="work-thumbnail" src="https://attachments.academia-assets.com/61423677/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/41183766/Commentaire_sur_Franck_Varenne_From_models_to_simulations">Commentaire sur : Franck Varenne, From models to simulations</a></div><div class="wp-workCard_item"><span>Revue d’histoire des sciences</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Franck Varenne, From models to simulations (Abington,Oxon ; New York, NY : Routledge, 2018), 15,9...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Franck Varenne, From models to simulations (Abington,Oxon ; New York, NY : Routledge, 2018), 15,9 x 23,5 cm, 224p., gloss., index, bibliogr. , coll. « History and philosophy of technosciences » 1 L'invention et le développement des ordinateurs a ouvert de nouvelles possibilités pour la modélisation. En physique, l'existence de théories mathématisées permet d'utiliser l'ordinateur pour calculer des solutions approchées à des problèmes déjà bien circonscrits théoriquement et épistémologiquement. En biologie, par contre, il n'existe pas de théorie jouant ce rôle épistémologique, et l'informatique a permis l'émergence de pratiques de modélisation combinant plusieurs cadres mathématiques. L'ouvrage de Franck Varenne porte sur ces pratiques novatrices, leur histoire et leur épistémologie, à travers le cas des simulations de morphogenèse d'arbres et plus généralement de plantes. Franck Varenne retrace l'émergence et le développement de ces pratiques en sept chapitres organisés chronologiquement et comportant une dimension épistémologique. Le dernier et huitième chapitre porte spécifiquement sur la philosophie des sciences et propose une classification des modèles. La lecture ne requiert pas de connaissances avancées en mathématiques ou en informatique. Cet ouvrage est, pour partie, une traduction, et il nous semble donc utile de noter que celle-ci est de très bonne qualité (traduction de Karen Turnbull en collaboration avec l'auteur). La question du statut épistémologique des simulations a été posée dès les travaux de Turing lorsqu'il décrit son approche de l'intelligence artificielle comme une imitation de l'intelligence humaine en 1950, et, à l'opposé, décrit son travail sur la morphogenèse comme une modélisation, en 1952. Dans l'histoire que retrace Franck Varenne, la question de la fonction épistémologique des modèles est décisive. Par exemple, la capacité à obtenir des représentations graphiques issues de simulations est un levier puissant pour l'interdisciplinarité car elle permet l'appréhension et la discussion des simulations par des botanistes. Mais ces représentations graphiques peuvent aussi engendrer la suspicion, car ce type de simulations agrège des modèles de statuts divers, 1 Publié dans Revue d'histoire des sciences I Tome 72-2 I juillet-décembre 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="266b41d1dc49f554f1a10b1c0d66baf0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":61423677,"asset_id":41183766,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/61423677/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="41183766"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="41183766"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 41183766; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=41183766]").text(description); $(".js-view-count[data-work-id=41183766]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 41183766; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='41183766']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 41183766, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "266b41d1dc49f554f1a10b1c0d66baf0" } } $('.js-work-strip[data-work-id=41183766]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":41183766,"title":"Commentaire sur : Franck Varenne, From models to simulations","translated_title":"","metadata":{"abstract":"Franck Varenne, From models to simulations (Abington,Oxon ; New York, NY : Routledge, 2018), 15,9 x 23,5 cm, 224p., gloss., index, bibliogr. , coll. « History and philosophy of technosciences » 1 L'invention et le développement des ordinateurs a ouvert de nouvelles possibilités pour la modélisation. 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La question du statut épistémologique des simulations a été posée dès les travaux de Turing lorsqu'il décrit son approche de l'intelligence artificielle comme une imitation de l'intelligence humaine en 1950, et, à l'opposé, décrit son travail sur la morphogenèse comme une modélisation, en 1952. Dans l'histoire que retrace Franck Varenne, la question de la fonction épistémologique des modèles est décisive. Par exemple, la capacité à obtenir des représentations graphiques issues de simulations est un levier puissant pour l'interdisciplinarité car elle permet l'appréhension et la discussion des simulations par des botanistes. Mais ces représentations graphiques peuvent aussi engendrer la suspicion, car ce type de simulations agrège des modèles de statuts divers, 1 Publié dans Revue d'histoire des sciences I Tome 72-2 I juillet-décembre 2019","internal_url":"https://www.academia.edu/41183766/Commentaire_sur_Franck_Varenne_From_models_to_simulations","translated_internal_url":"","created_at":"2019-12-04T11:57:51.313-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28744524,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":61423677,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/61423677/thumbnails/1.jpg","file_name":"livre-varenne20191204-80196-1db0l4c.pdf","download_url":"https://www.academia.edu/attachments/61423677/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Commentaire_sur_Franck_Varenne_From_mode.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/61423677/livre-varenne20191204-80196-1db0l4c-libre.pdf?1575494116=\u0026response-content-disposition=attachment%3B+filename%3DCommentaire_sur_Franck_Varenne_From_mode.pdf\u0026Expires=1731456345\u0026Signature=I-BsslkG83vAXFeiwVLsbmwgwdkW1Q4pcaS2SiV0q9hOup7HfqyLXZqLZ2REvKzE2GNJvccgXzYRr5R34pSPqbASG9ry8K-grac5LKtPCGnlCT3BKFSc5agnvXqLsvVrPh9mMwWmawYeeEL0768TnotMNBbO08ViW5pTtfSeqEvvdtC4EYdk0a2HFctD9CizZ7oej1cALAoWqyzmFLq3dQEc3fWccUDcNQw1ssJ0ZVOOsbcZKpH2LW4jqNSNjIOa07pENonZ4yX~Y0BNhixJKTalQzifMYqceVURMTuSKe3ynnWdN4nDLOj756x7VYi6m0n~F5yMhXXtkllNQLSqNA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Commentaire_sur_Franck_Varenne_From_models_to_simulations","translated_slug":"","page_count":3,"language":"fr","content_type":"Work","owner":{"id":28744524,"first_name":"Maël","middle_initials":null,"last_name":"Montévil","page_name":"MaëlMontévil","domain_name":"ens","created_at":"2015-03-30T06:26:30.969-07:00","display_name":"Maël Montévil","url":"https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil"},"attachments":[{"id":61423677,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/61423677/thumbnails/1.jpg","file_name":"livre-varenne20191204-80196-1db0l4c.pdf","download_url":"https://www.academia.edu/attachments/61423677/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Commentaire_sur_Franck_Varenne_From_mode.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/61423677/livre-varenne20191204-80196-1db0l4c-libre.pdf?1575494116=\u0026response-content-disposition=attachment%3B+filename%3DCommentaire_sur_Franck_Varenne_From_mode.pdf\u0026Expires=1731456346\u0026Signature=ReMhh6apyoK8BSIeVvvxcRWNCsMulApBhgctz7dn2JaW2bGM56vk4Y6cvFD9PE0ktviXf7Qz8i0ABD0t7aBRnufGRx36ZfEyKYtwssZevYHHVtVMznjvjtn0zGEHzjtS6fpK5ia~Nx55gG8uoBvedgiDqGcBNAj2eFOa0T43h44h9T3v1tZW2XkBlvDhrSjEqCUVx4c2cz~mFyFIvxJo9YrW6~-mATnb76vkNVM2J6xaDR6oq8HRxF8CZbFP7~-EpDFQ1EjWE-rJqJQ1MGj2bxFmE5yZP2mnqsd9JBn9uiJZYXTEOaF~nLSgY~ntybCfzieM77KOADR5MLnSnTSJrQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":11820,"name":"Modeling and Simulation","url":"https://www.academia.edu/Documents/in/Modeling_and_Simulation"},{"id":48636,"name":"Simulation","url":"https://www.academia.edu/Documents/in/Simulation"},{"id":172797,"name":"Plant morphology and anatomy","url":"https://www.academia.edu/Documents/in/Plant_morphology_and_anatomy"},{"id":200348,"name":"Modélisation","url":"https://www.academia.edu/Documents/in/Mod%C3%A9lisation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="6612368" id="inprogress"><div class="js-work-strip profile--work_container" data-work-id="31682372"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31682372/Giving_substance_to_biological_information_subm_"><img alt="Research paper thumbnail of Giving substance to biological information (subm.)" class="work-thumbnail" src="https://attachments.academia-assets.com/52122970/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31682372/Giving_substance_to_biological_information_subm_">Giving substance to biological information (subm.)</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://cnrs.academia.edu/ArnaudPocheville">Arnaud Pocheville</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The idea that biological information is created by evolution, passed on in heredity, and expresse...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The idea that biological information is created by evolution, passed on in heredity, and expressed during development is an attractive gloss on what has been revealed by the last century of advances in biology. But on closer examination it is hard to see what scientific substance corresponds to this vision. Several biologists and philosophers of biology have suggested that `biological information' is no more than a collection of loose metaphors. Others have offered their own theories of biological information, but most of these have been oddly unrelated to actual biological practice. Here we argue that the  conception of information used by Francis Crick in his `sequence hypothesis' and `central dogma', a conception closely related to the older idea of `biological specificity', is adequate to state a substantial, general theory of biological information. There are two aspects to this account, corresponding to a fundamental duality in information theory between Shannon and Kolmogorov measures.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ca848b7daf13e75ecc4143551bc1ecb2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":52122970,"asset_id":31682372,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/52122970/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31682372"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31682372"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31682372; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31682372]").text(description); $(".js-view-count[data-work-id=31682372]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31682372; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31682372']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31682372, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ca848b7daf13e75ecc4143551bc1ecb2" } } $('.js-work-strip[data-work-id=31682372]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31682372,"title":"Giving substance to biological information (subm.)","translated_title":"","metadata":{"abstract":"The idea that biological information is created by evolution, passed on in heredity, and expressed during development is an attractive gloss on what has been revealed by the last century of advances in biology. But on closer examination it is hard to see what scientific substance corresponds to this vision. Several biologists and philosophers of biology have suggested that `biological information' is no more than a collection of loose metaphors. Others have offered their own theories of biological information, but most of these have been oddly unrelated to actual biological practice. Here we argue that the conception of information used by Francis Crick in his `sequence hypothesis' and `central dogma', a conception closely related to the older idea of `biological specificity', is adequate to state a substantial, general theory of biological information. There are two aspects to this account, corresponding to a fundamental duality in information theory between Shannon and Kolmogorov measures."},"translated_abstract":"The idea that biological information is created by evolution, passed on in heredity, and expressed during development is an attractive gloss on what has been revealed by the last century of advances in biology. But on closer examination it is hard to see what scientific substance corresponds to this vision. Several biologists and philosophers of biology have suggested that `biological information' is no more than a collection of loose metaphors. Others have offered their own theories of biological information, but most of these have been oddly unrelated to actual biological practice. Here we argue that the conception of information used by Francis Crick in his `sequence hypothesis' and `central dogma', a conception closely related to the older idea of `biological specificity', is adequate to state a substantial, general theory of biological information. There are two aspects to this account, corresponding to a fundamental duality in information theory between Shannon and Kolmogorov measures.","internal_url":"https://www.academia.edu/31682372/Giving_substance_to_biological_information_subm_","translated_internal_url":"","created_at":"2017-03-02T12:19:04.033-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9444291,"coauthors_can_edit":true,"document_type":"other","co_author_tags":[{"id":27992921,"work_id":31682372,"tagging_user_id":9444291,"tagged_user_id":28744524,"co_author_invite_id":null,"email":"m***l@gmail.com","affiliation":"École Normale Supérieure","display_order":1,"name":"Maël Montévil","title":"Giving substance to biological information (subm.)"}],"downloadable_attachments":[{"id":52122970,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52122970/thumbnails/1.jpg","file_name":"crick-information-giving-20170312.pdf","download_url":"https://www.academia.edu/attachments/52122970/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Giving_substance_to_biological_informati.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52122970/crick-information-giving-20170312-libre.pdf?1489327854=\u0026response-content-disposition=attachment%3B+filename%3DGiving_substance_to_biological_informati.pdf\u0026Expires=1731944786\u0026Signature=L8K9Y0n3LD77BinPlZGIZdpjGSl~QS7OezrlznA9l3Q7a-RIBUKLuPJ~fPvYjKBUDIDzAMi2rtRSeN2D57p38fBTyeHx903OMMA~nhtLdR5mp~Ahbnbak~WM29slVRYzx0qXozePTxwKRSywcaVhuVBsS7OS3bh6E5gRvZ2WtZk6dLhDRDSmnVpSSib65nIKmPTulH3LSI7r-pzUN8AyYFsGxSmK6gIedpN6CpkgY-SAsRe6WN~7C9jEs1OiPi41JCib7RqVxU89YpddqpYTuTtPdEuMHZXHcj0EdasRovDw-qml-vsInOm4IDetEEuymtT7kgN5KKzWZTtSkh7F7A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Giving_substance_to_biological_information_subm_","translated_slug":"","page_count":28,"language":"en","content_type":"Work","owner":{"id":9444291,"first_name":"Arnaud","middle_initials":"","last_name":"Pocheville","page_name":"ArnaudPocheville","domain_name":"cnrs","created_at":"2014-02-24T02:08:52.108-08:00","display_name":"Arnaud Pocheville","url":"https://cnrs.academia.edu/ArnaudPocheville"},"attachments":[{"id":52122970,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52122970/thumbnails/1.jpg","file_name":"crick-information-giving-20170312.pdf","download_url":"https://www.academia.edu/attachments/52122970/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Giving_substance_to_biological_informati.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52122970/crick-information-giving-20170312-libre.pdf?1489327854=\u0026response-content-disposition=attachment%3B+filename%3DGiving_substance_to_biological_informati.pdf\u0026Expires=1731944787\u0026Signature=UsllDjOYfflwW5JjN2Jymc7CcuT4Zg789quRxfpzpTnZliBeI9hdRPcnCttuFb1Ze~YJxa6Ygf52uUEzzchWfXDaO0LHdQ1Id~u-ojI5XqcwUJTldL2EXacT5vg0eE5aiIIHyjhcKiNE3QpfHy2984CthnxmwADAo5~Cupx26ormX5HsiZtRndbfn~0pEgkFX4cKS8KcmNS1ok2W-IoSjJIe06SlJU0lzKElUeik5rrVnRj2ZwWP-uX7D2J1fBq8KCapZd0~WW6JIqzVhbU6NY2HEg4omPpD8tjdrYQy1OELJesg6NvTlZAKIajzmXLRwPiFU6EuxPrgsBtpDUoeXw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":821,"name":"Philosophy of Science","url":"https://www.academia.edu/Documents/in/Philosophy_of_Science"},{"id":1410,"name":"Information Theory","url":"https://www.academia.edu/Documents/in/Information_Theory"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":8220,"name":"Causation","url":"https://www.academia.edu/Documents/in/Causation"},{"id":328376,"name":"Biological information","url":"https://www.academia.edu/Documents/in/Biological_information"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31682377"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31682377/Intervening_in_a_continuous_world_when_Achilles_meets_his_tortoise_subm_"><img alt="Research paper thumbnail of Intervening in a continuous world: when Achilles meets his tortoise (subm.)" class="work-thumbnail" src="https://attachments.academia-assets.com/52114754/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31682377/Intervening_in_a_continuous_world_when_Achilles_meets_his_tortoise_subm_">Intervening in a continuous world: when Achilles meets his tortoise (subm.)</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://cnrs.academia.edu/ArnaudPocheville">Arnaud Pocheville</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The interventionist account has gained momentum within philosophy of causation. However, its abil...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The interventionist account has gained momentum within philosophy of<br />causation. However, its ability to account for explanations derived from<br />dynamical systems has been put into question. In particular, it has been<br />argued that the fact that one cannot intervene on a function and its time-<br />derivative in a modular way, i.e. without affecting the other, is an issue.<br />Here, we develop a solution to this issue. We leverage on differential cal-<br />culus to formalize interventions that are as precise as desired. Functions<br />and their time-derivatives can then be manipulated in a modular way at<br />any arbitrary degree of precision. This leads us to propose an interven-<br />tionist, causal interpretation of differential equations, similar to the causal<br />interpretation of structural equations. We emphasize that continuous time<br />dynamical systems can be approximated at an arbitrary degree of precision<br />by a causal graph approach. We conclude that causal graphs and continuous<br />time dynamical systems constitute two compatible, complementary causal<br />formalisms for interventionism.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c07991ec4b13d7fcdfee646070951221" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":52114754,"asset_id":31682377,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/52114754/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31682377"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31682377"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31682377; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31682377]").text(description); $(".js-view-count[data-work-id=31682377]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31682377; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31682377']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31682377, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c07991ec4b13d7fcdfee646070951221" } } $('.js-work-strip[data-work-id=31682377]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31682377,"title":"Intervening in a continuous world: when Achilles meets his tortoise (subm.)","translated_title":"","metadata":{"abstract":"The interventionist account has gained momentum within philosophy of\ncausation. However, its ability to account for explanations derived from\ndynamical systems has been put into question. In particular, it has been\nargued that the fact that one cannot intervene on a function and its time-\nderivative in a modular way, i.e. without affecting the other, is an issue.\nHere, we develop a solution to this issue. We leverage on differential cal-\nculus to formalize interventions that are as precise as desired. Functions\nand their time-derivatives can then be manipulated in a modular way at\nany arbitrary degree of precision. This leads us to propose an interven-\ntionist, causal interpretation of differential equations, similar to the causal\ninterpretation of structural equations. We emphasize that continuous time\ndynamical systems can be approximated at an arbitrary degree of precision\nby a causal graph approach. We conclude that causal graphs and continuous\ntime dynamical systems constitute two compatible, complementary causal\nformalisms for interventionism."},"translated_abstract":"The interventionist account has gained momentum within philosophy of\ncausation. However, its ability to account for explanations derived from\ndynamical systems has been put into question. In particular, it has been\nargued that the fact that one cannot intervene on a function and its time-\nderivative in a modular way, i.e. without affecting the other, is an issue.\nHere, we develop a solution to this issue. We leverage on differential cal-\nculus to formalize interventions that are as precise as desired. Functions\nand their time-derivatives can then be manipulated in a modular way at\nany arbitrary degree of precision. This leads us to propose an interven-\ntionist, causal interpretation of differential equations, similar to the causal\ninterpretation of structural equations. We emphasize that continuous time\ndynamical systems can be approximated at an arbitrary degree of precision\nby a causal graph approach. We conclude that causal graphs and continuous\ntime dynamical systems constitute two compatible, complementary causal\nformalisms for interventionism.","internal_url":"https://www.academia.edu/31682377/Intervening_in_a_continuous_world_when_Achilles_meets_his_tortoise_subm_","translated_internal_url":"","created_at":"2017-03-02T12:20:02.340-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9444291,"coauthors_can_edit":true,"document_type":"other","co_author_tags":[{"id":27854222,"work_id":31682377,"tagging_user_id":9444291,"tagged_user_id":28744524,"co_author_invite_id":null,"email":"m***l@gmail.com","affiliation":"École Normale Supérieure","display_order":0,"name":"Maël Montévil","title":"Intervening in a continuous world: when Achilles meets his tortoise (subm.)"}],"downloadable_attachments":[{"id":52114754,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52114754/thumbnails/1.jpg","file_name":"intervening-continuous-world-20170311.pdf","download_url":"https://www.academia.edu/attachments/52114754/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Intervening_in_a_continuous_world_when_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52114754/intervening-continuous-world-20170311-libre.pdf?1489252974=\u0026response-content-disposition=attachment%3B+filename%3DIntervening_in_a_continuous_world_when_A.pdf\u0026Expires=1732359831\u0026Signature=U1EhB54NaHt9hzZfZtu~C2nWNGJjExqRbQ~tfK8uwEdJW7-smFz-8s20LQGhPMVi9md93~mzbb56aNEWjTXgB0kAqnahpG5QITKj5bVJ7XMrIoL9A3UcKxW4~9NM49NEik5-XPAe5xCWqvkjvL6HsMg0ceRxlAA3HkPumEaGyRxV-2PsnhcNvMZ9wZNfHiDsrf1h7Y8SA2RxiYt7Wmwpo9hC9p9NdlfWM8DE4sI9Ti7WyNnN8-YdjmL5MctAtEKqBdYxkaoU6PUl~~RrIizXjcToQpgUnLyANMsjPVjGfTLHEm~AssNVv0xDhShxMAQHC7eVHCaOZGPFh-bk0JcIAA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Intervening_in_a_continuous_world_when_Achilles_meets_his_tortoise_subm_","translated_slug":"","page_count":25,"language":"en","content_type":"Work","owner":{"id":9444291,"first_name":"Arnaud","middle_initials":"","last_name":"Pocheville","page_name":"ArnaudPocheville","domain_name":"cnrs","created_at":"2014-02-24T02:08:52.108-08:00","display_name":"Arnaud Pocheville","url":"https://cnrs.academia.edu/ArnaudPocheville"},"attachments":[{"id":52114754,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52114754/thumbnails/1.jpg","file_name":"intervening-continuous-world-20170311.pdf","download_url":"https://www.academia.edu/attachments/52114754/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Intervening_in_a_continuous_world_when_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52114754/intervening-continuous-world-20170311-libre.pdf?1489252974=\u0026response-content-disposition=attachment%3B+filename%3DIntervening_in_a_continuous_world_when_A.pdf\u0026Expires=1732359831\u0026Signature=U1EhB54NaHt9hzZfZtu~C2nWNGJjExqRbQ~tfK8uwEdJW7-smFz-8s20LQGhPMVi9md93~mzbb56aNEWjTXgB0kAqnahpG5QITKj5bVJ7XMrIoL9A3UcKxW4~9NM49NEik5-XPAe5xCWqvkjvL6HsMg0ceRxlAA3HkPumEaGyRxV-2PsnhcNvMZ9wZNfHiDsrf1h7Y8SA2RxiYt7Wmwpo9hC9p9NdlfWM8DE4sI9Ti7WyNnN8-YdjmL5MctAtEKqBdYxkaoU6PUl~~RrIizXjcToQpgUnLyANMsjPVjGfTLHEm~AssNVv0xDhShxMAQHC7eVHCaOZGPFh-bk0JcIAA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":821,"name":"Philosophy of Science","url":"https://www.academia.edu/Documents/in/Philosophy_of_Science"},{"id":1080,"name":"Dynamical Systems","url":"https://www.academia.edu/Documents/in/Dynamical_Systems"},{"id":8220,"name":"Causation","url":"https://www.academia.edu/Documents/in/Causation"}],"urls":[]}, dispatcherData: dispatcherData }); 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Percorsi filosofico-politici a partire da La società automatica di Bernard Stiegler/Le gouvernement de l'entropie. Parcours philosophico-politiques à partir de La société automatique de Bernard Stiegler (Università di Padova, October 9th 2019)" class="work-thumbnail" src="https://attachments.academia-assets.com/60776882/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/40505117/Il_governo_dellentropia_Percorsi_filosofico_politici_a_partire_da_La_societ%C3%A0_automatica_di_Bernard_Stiegler_Le_gouvernement_de_lentropie_Parcours_philosophico_politiques_%C3%A0_partir_de_La_soci%C3%A9t%C3%A9_automatique_de_Bernard_Stiegler_Universit%C3%A0_di_Padova_October_9th_2019_">Il governo dell'entropia. Percorsi filosofico-politici a partire da La società automatica di Bernard Stiegler/Le gouvernement de l'entropie. Parcours philosophico-politiques à partir de La société automatique de Bernard Stiegler (Università di Padova, October 9th 2019)</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipd.academia.edu/MarcoFerrari">Marco Ferrari</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://ehess.academia.edu/EdoardoToffoletto">Edoardo Toffoletto</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unipd.academia.edu/GiovanniMinozzi">Giovanni Minozzi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://ens.academia.edu/Ma%C3%ABlMont%C3%A9vil">Maël Montévil</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://isevenezia.academia.edu/paolovignola">paolo vignola</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cosa significa governare l’entropia? Possono esistere differenti modi di farlo? È possibile affer...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cosa significa governare l’entropia? Possono esistere differenti modi di farlo? È possibile affermare che esistano un buono e un cattivo governo dell’entropia?<br /><br />Cominciare a riflettere circa la possibilità di fornire una risposta a questioni di questo tipo costituisce uno degli obiettivi di questo convegno. Per farlo abbiamo deciso di provare a costruire un dialogo – a partire dall’opera di B. Stiegler e, più specificamente, da La société automatique, in occasione della pubblicazione della sua traduzione in lingua italiana – tra alcune prospettive delineatesi, negli ultimi anni, all’interno di gruppi di ricerca differenti orbitanti attorno all’Università di Padova, da un lato, e l’Institut de recherche et d'innovation coordinato da B. Stiegler, dall’altro.<br /><br />Concetti chiave:<br />governo, concetti politici moderni, sovranità, storia epistemologica dei concetti politici, exo-somatizzazione, ex-organologia generale, individuazione, trans-individuazione, rétentions tertiaires hypomnésiques, farmacologia, entropia, anti-entropia, negentropia, economia contributiva<br /><br />Qu’est-ce que signifie gouverner l’entropie ? Peut-il-y en avoir différentes formes ?  Est-il possible d’affirmer qu’il y a un bon et un mauvais gouvernement de l’entropie ? <br /><br />Un des objectifs de ce colloque est de réfléchir à la possibilité de répondre à ce genre de questions. Avec cette finalité, on a cherché de construire un dialogue – à partir de l’œuvre de B. Stiegler et de La société automatique en particulier, contextuellement à la publication de sa traduction italienne – entre d’un coté des perspectives tracées dans les dernières années par de différents groupes de recherche rattachés à l’Université de Padoue, et de l’autre, l’Institut de Recherche et d’Innovation coordonné par Bernard Stiegler.<br /><br />Mots clés:<br />gouvernement, concepts politiques modernes, souveraineté, histoire épistémologique des concepts politiques, exo-somatisation, ex-organologie générale, individuation, trans-individuation, rétentions tertiaires hypomnésiques, pharmacologie, entropie, anti-entropie, néguentropie, économie contributive.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="971adbfe61ebaf9544d7f9f0c59a6a30" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":60776882,"asset_id":40505117,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/60776882/download_file?st=MTczMjQxMDMwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="40505117"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="40505117"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 40505117; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=40505117]").text(description); $(".js-view-count[data-work-id=40505117]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 40505117; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='40505117']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 40505117, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "971adbfe61ebaf9544d7f9f0c59a6a30" } } $('.js-work-strip[data-work-id=40505117]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":40505117,"title":"Il governo dell'entropia. Percorsi filosofico-politici a partire da La società automatica di Bernard Stiegler/Le gouvernement de l'entropie. Parcours philosophico-politiques à partir de La société automatique de Bernard Stiegler (Università di Padova, October 9th 2019)","translated_title":"","metadata":{"abstract":"Cosa significa governare l’entropia? Possono esistere differenti modi di farlo? È possibile affermare che esistano un buono e un cattivo governo dell’entropia?\n\nCominciare a riflettere circa la possibilità di fornire una risposta a questioni di questo tipo costituisce uno degli obiettivi di questo convegno. Per farlo abbiamo deciso di provare a costruire un dialogo – a partire dall’opera di B. Stiegler e, più specificamente, da La société automatique, in occasione della pubblicazione della sua traduzione in lingua italiana – tra alcune prospettive delineatesi, negli ultimi anni, all’interno di gruppi di ricerca differenti orbitanti attorno all’Università di Padova, da un lato, e l’Institut de recherche et d'innovation coordinato da B. Stiegler, dall’altro.\n\nConcetti chiave:\ngoverno, concetti politici moderni, sovranità, storia epistemologica dei concetti politici, exo-somatizzazione, ex-organologia generale, individuazione, trans-individuazione, rétentions tertiaires hypomnésiques, farmacologia, entropia, anti-entropia, negentropia, economia contributiva\n\nQu’est-ce que signifie gouverner l’entropie ? Peut-il-y en avoir différentes formes ? Est-il possible d’affirmer qu’il y a un bon et un mauvais gouvernement de l’entropie ? \n\nUn des objectifs de ce colloque est de réfléchir à la possibilité de répondre à ce genre de questions. Avec cette finalité, on a cherché de construire un dialogue – à partir de l’œuvre de B. Stiegler et de La société automatique en particulier, contextuellement à la publication de sa traduction italienne – entre d’un coté des perspectives tracées dans les dernières années par de différents groupes de recherche rattachés à l’Université de Padoue, et de l’autre, l’Institut de Recherche et d’Innovation coordonné par Bernard Stiegler.\n\nMots clés:\ngouvernement, concepts politiques modernes, souveraineté, histoire épistémologique des concepts politiques, exo-somatisation, ex-organologie générale, individuation, trans-individuation, rétentions tertiaires hypomnésiques, pharmacologie, entropie, anti-entropie, néguentropie, économie contributive.\n"},"translated_abstract":"Cosa significa governare l’entropia? Possono esistere differenti modi di farlo? È possibile affermare che esistano un buono e un cattivo governo dell’entropia?\n\nCominciare a riflettere circa la possibilità di fornire una risposta a questioni di questo tipo costituisce uno degli obiettivi di questo convegno. Per farlo abbiamo deciso di provare a costruire un dialogo – a partire dall’opera di B. Stiegler e, più specificamente, da La société automatique, in occasione della pubblicazione della sua traduzione in lingua italiana – tra alcune prospettive delineatesi, negli ultimi anni, all’interno di gruppi di ricerca differenti orbitanti attorno all’Università di Padova, da un lato, e l’Institut de recherche et d'innovation coordinato da B. Stiegler, dall’altro.\n\nConcetti chiave:\ngoverno, concetti politici moderni, sovranità, storia epistemologica dei concetti politici, exo-somatizzazione, ex-organologia generale, individuazione, trans-individuazione, rétentions tertiaires hypomnésiques, farmacologia, entropia, anti-entropia, negentropia, economia contributiva\n\nQu’est-ce que signifie gouverner l’entropie ? Peut-il-y en avoir différentes formes ? Est-il possible d’affirmer qu’il y a un bon et un mauvais gouvernement de l’entropie ? \n\nUn des objectifs de ce colloque est de réfléchir à la possibilité de répondre à ce genre de questions. Avec cette finalité, on a cherché de construire un dialogue – à partir de l’œuvre de B. 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