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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="5VcBqRwElgC2SACIFXOwHjZOugIVd6vXbSdueQ+kKDxwRr5cgOFV8vFDUsiwR/olGMLO7gVRl78HffwEmGQ1ig==" /> <meta name="citation_title" content="In vitro screening for the tumoricidal properties of international medicinal herbs" /> <meta name="citation_publication_date" content="2009/01/01" /> <meta name="citation_journal_title" content="Phytotherapy Research" /> <meta name="citation_author" content="Karam Soliman" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/5581350/In_vitro_screening_for_the_tumoricidal_properties_of_international_medicinal_herbs" /> <meta name="twitter:title" content="In vitro screening for the tumoricidal properties of international medicinal herbs" /> <meta name="twitter:description" content="There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. 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The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives" /> <title>(PDF) In vitro screening for the tumoricidal properties of international medicinal herbs | Karam Soliman - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/21255571/In_vitro_screening_for_the_tumoricidal_properties_of_international_medicinal_herbs" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '2f444c8e4ed6011e01999d24d77abd5ec19178fb'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732740716000); window.Aedu.timeDifference = new Date().getTime() - 1732740716000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives for cancer treatment and potential new chemotherapy drug sources. In this study, 374 natural extracts (10 µg/mL–5 mg/mL) were evaluated for dose-dependent tumoricidal effects using immortal neuroblastoma of spontaneous malignant origin. The findings indicate no pattern of tumoricidal effects by diverse plants with similar families/genus under the classes Pinopsida, Equisetopsida, Lycopodiosida, Filicosida, Liliopsida Monocotyledons or Magnoliopsida Dicotyledons. The results indicate that many of the most commonly used CAMs exhibited relatively weak tumoricidal effects including cats claw, astragalus, ginseng, echinacea, mistletoe, milk thistle, slippery elm, cayenne, chamomile, don quai, meadowsweet, motherwort and shepherd\u0026amp;amp;amp;amp;amp;amp;#x27;s purse. The data demonstrate that the most potent plant extracts were randomly dispersed within the plantae kingdom (LC50 = 31–490 µg/mL) in order of the lowest LC50 Dioscorea villosa (Dioscoreaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Sanguinaria canadensis (Papaveraceae) \u0026amp;amp;amp;amp;amp;amp;gt; Dipsacus asper (Dipsacaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Populus balsamifera (Salicaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Boswellia carteri (Burseraceae) \u0026amp;amp;amp;amp;amp;amp;gt; Cyamopsis psoralioides (Fabaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Rhamnus cathartica (Rhamnaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Larrea tridentate (Zygophyllaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Dichroa febrifuga (Hydrangeaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Batschia canescens (Boraginaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Kochia scoparia (Chenopodiaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Solanum xanthocarpum (Solanaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Opoponax chironium (Umbelliferae) \u0026amp;amp;amp;amp;amp;amp;gt; Caulophyllum thalictroides (Berberidaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Dryopteris crassirhizoma (Dryopteridaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Garcinia cambogia (Clusiaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Vitex agnus-castus (Verbenaceae) \u0026amp;amp;amp;amp;amp;amp;gt; Calamus draco (Arecaceae). These findings show tumoricidal effect by extracts of wild yam root, bloodroot, teasel root, bakuchi seed, dichroa root, kanta kari, garcinia fruit, mace, dragons blood and the biblically referenced herbs: balm of gilead bud, frankincense and myrrh gum. Copyright © 2008 John Wiley \u0026amp;amp;amp;amp;amp;amp;amp; Sons, Ltd.","author":[{"@context":"https://schema.org","@type":"Person","name":"Karam Soliman"}],"contributor":[],"dateCreated":"2014-01-02","dateModified":"2024-01-21","datePublished":"2009-01-01","headline":"In vitro screening for the tumoricidal properties of international medicinal herbs","inLanguage":"en","keywords":[],"locationCreated":null,"publication":"Phytotherapy Research","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Wiley"},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/5581350/In_vitro_screening_for_the_tumoricidal_properties_of_international_medicinal_herbs","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"famu"}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-102fa537001ba4d8dcd921ad9bd56c474abc201906ea4843e7e7efe9dfbf561d.css" /><link rel="stylesheet" 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worldwide. The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives for cancer treatment and potential new chemotherapy drug sources. In this study, 374 natural extracts (10 µg/mL–5 mg/mL) were evaluated for dose-dependent tumoricidal effects using immortal neuroblastoma of spontaneous malignant origin. The findings indicate no pattern of tumoricidal effects by diverse plants with similar families/genus under the classes Pinopsida, Equisetopsida, Lycopodiosida, Filicosida, Liliopsida Monocotyledons or Magnoliopsida Dicotyledons. The results indicate that many of the most commonly used CAMs exhibited relatively weak tumoricidal effects including cats claw, astragalus, ginseng, echinacea, mistletoe, milk thistle, slippery elm, cayenne, chamomile, don quai, meadowsweet, motherwort and shepherd's purse. The data demonstrate that the most potent plant extracts were randomly dispersed within the plantae kingdom (LC50 = 31–490 µg/mL) in order of the lowest LC50 Dioscorea villosa (Dioscoreaceae) \u003e Sanguinaria canadensis (Papaveraceae) \u003e Dipsacus asper (Dipsacaceae) \u003e Populus balsamifera (Salicaceae) \u003e Boswellia carteri (Burseraceae) \u003e Cyamopsis psoralioides (Fabaceae) \u003e Rhamnus cathartica (Rhamnaceae) \u003e Larrea tridentate (Zygophyllaceae) \u003e Dichroa febrifuga (Hydrangeaceae) \u003e Batschia canescens (Boraginaceae) \u003e Kochia scoparia (Chenopodiaceae) \u003e Solanum xanthocarpum (Solanaceae) \u003e Opoponax chironium (Umbelliferae) \u003e Caulophyllum thalictroides (Berberidaceae) \u003e Dryopteris crassirhizoma (Dryopteridaceae) \u003e Garcinia cambogia (Clusiaceae) \u003e Vitex agnus-castus (Verbenaceae) \u003e Calamus draco (Arecaceae). These findings show tumoricidal effect by extracts of wild yam root, bloodroot, teasel root, bakuchi seed, dichroa root, kanta kari, garcinia fruit, mace, dragons blood and the biblically referenced herbs: balm of gilead bud, frankincense and myrrh gum. Copyright © 2008 John Wiley \u0026 Sons, Ltd.","publication_date":"2009,,","publication_name":"Phytotherapy Research"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"In vitro screening for the tumoricidal properties of international medicinal herbs","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [7953118]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":49230780,"attachmentType":"pdf"}"><img alt="First page of “In vitro screening for the tumoricidal properties of international medicinal herbs”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/49230780/mini_magick20190201-17863-rkwvv9.png?1549024777" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">In vitro screening for the tumoricidal properties of international medicinal herbs</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="7953118" href="https://famu.academia.edu/KSoliman"><img alt="Profile image of Karam Soliman" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Karam Soliman</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2009, Phytotherapy Research</p></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives for cancer treatment and potential new chemotherapy drug sources. In this study, 374 natural extracts (10 µg/mL–5 mg/mL) were evaluated for dose-dependent tumoricidal effects using immortal neuroblastoma of spontaneous malignant origin. The findings indicate no pattern of tumoricidal effects by diverse plants with similar families/genus under the classes Pinopsida, Equisetopsida, Lycopodiosida, Filicosida, Liliopsida Monocotyledons or Magnoliopsida Dicotyledons. The results indicate that many of the most commonly used CAMs exhibited relatively weak tumoricidal effects including cats claw, astragalus, ginseng, echinacea, mistletoe, milk thistle, slippery elm, cayenne, chamomile, don quai, meadowsweet, motherwort and shepherd's purse. The data demonstrate that the most potent plant extracts were randomly dispersed within the plantae kingdom (LC50 = 31–490 µg/mL) in order of the lowest LC50 Dioscorea villosa (Dioscoreaceae) > Sanguinaria canadensis (Papaveraceae) > Dipsacus asper (Dipsacaceae) > Populus balsamifera (Salicaceae) > Boswellia carteri (Burseraceae) > Cyamopsis psoralioides (Fabaceae) > Rhamnus cathartica (Rhamnaceae) > Larrea tridentate (Zygophyllaceae) > Dichroa febrifuga (Hydrangeaceae) > Batschia canescens (Boraginaceae) > Kochia scoparia (Chenopodiaceae) > Solanum xanthocarpum (Solanaceae) > Opoponax chironium (Umbelliferae) > Caulophyllum thalictroides (Berberidaceae) > Dryopteris crassirhizoma (Dryopteridaceae) > Garcinia cambogia (Clusiaceae) > Vitex agnus-castus (Verbenaceae) > Calamus draco (Arecaceae). These findings show tumoricidal effect by extracts of wild yam root, bloodroot, teasel root, bakuchi seed, dichroa root, kanta kari, garcinia fruit, mace, dragons blood and the biblically referenced herbs: balm of gilead bud, frankincense and myrrh gum. Copyright © 2008 John Wiley & Sons, Ltd.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":49230780,"attachmentType":"pdf","workUrl":"https://www.academia.edu/5581350/In_vitro_screening_for_the_tumoricidal_properties_of_international_medicinal_herbs"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":49230780,"attachmentType":"pdf","workUrl":"https://www.academia.edu/5581350/In_vitro_screening_for_the_tumoricidal_properties_of_international_medicinal_herbs"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="49230780" 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Most chemotherapeutic drugs for cancer treatment are molecules identified and isolated from plants or their synthetic derivatives. Our hypothesis was that whole plant extracts selected according to ethnobotanical sources of historical use might contain multiple molecules with antitumor activities that could be very effective in killing human cancer cells. This study examined the effects of three whole plant extracts (ethanol extraction) on human tumor cells. The extracts were from Urtica membranacea (Urticaceae), Artemesia monosperma (Asteraceae), and Origanum dayi post (Labiatae). All three plant extracts exhibited dose- and time-dependent killing capabilities in various human derived tumor cell lines and primary cultures established from patients&#39; biopsies. 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The earliest records regarding the use of medicinal plants are obtained from Mesopotamian civilizations and are as old as 2600 BC (Gurib-Fakim 2006). History shows that plants with medicinal properties had been in use in Assyrians, Babylonians, Chinese, Greeks, and Hebrews civilizations (Hamayun 2007). Furthermore, people in rural areas have always used native plants and herbs as medicines (Shinwari and Khan 2000) partly due to the wide gap of educational, research, and health facilities between the rural and urban areas and partly because of socioeconomic issues (Hamayun et al. 2006b). The mid of twentieth century witnessed an advancement in various fields of life and simultaneously the use of synthetic chemical compounds for therapeutic purposes became widespread (Hamayun et al. 2006a). However, in a short time, the worth of medicinal plants came to spotlight again when the researchers failed to produce comparatively affordable and safe medicines and thus herbal medicine experienced a revival especially in Western society. It is still in practice throughout the world along with corresponding therapies such as traditional Chinese medicine (TCM), homeopathy, and osteopathy (Hamayun et al. 2006b). According to an estimate, 20,000 species of plants are used throughout the world for medicinal purposes (Hamayun 2007) and 50% of all the clinically used drugs are obtained from natural products and their derivatives (Gurib-Fakim 2006; Rosangkima and Prasad 2004). World Health Organization (WHO) reckons that 80% of the world’s population depends on plants for health services (Shinwari and Gilani 2003; Saumya et al. n.d.; Madhuri and Pandey 2008) and in developed countries 25% of all medicines prescribed contain ingredients derived from medicinal plants (Qureshi et al. 2009). Cancer is the second leading cause of death after cardiovascular diseases worldwide (Jackson 2000). According to American Cancer Society, 3500 million people are killed every year from cancer (American Cancer Society n.d.). Cancer is defined as “a group of diseases that are characterized by the presence of malignant cells which proliferate in an unrestricted manner and ultimately invade the tissues and disseminate the organs (metastasis) to form secondary areas of growth known as secondary tumors” (Moura et al. 2001). According to National Cancer Institute (NCI), 35,000 species of plants out of 250,000–350,000 are used for anti-cancerous purposes worldwide whereas, in Pakistan, 400–600 out of 6000 species of wild plants are considered to be of medicinal worth (Hamayun 2007). Saumya reported that 60% of anti-cancerous drugs used clinically are obtained from natural sources (Saumya et al. n.d.). After many years of extensive research on medicinal plants possessing chemotherapeutic properties (Aphanamixis polystachya, Alhagi pseudalhagi, Annona squamosa, Calamus rotang, Cirsium rhinoceros, Terminalia arjuna, Euphorbia jolkini, Polygonum cuspidatum, Myrica rubra Sieb et Zucc, Centella asiatica, Bupleurum kaoi, Ochrosia elliptica Labill, Stephania tetrandra, Ophiorrhiza mungos, Ornithogalum umbellatum, Taxus brevifolia, Tabernaemontana divaricata, Paederia scandens, Elephantopus scaber, Impatiens balsamina, Coix lachryma, Rhei Rhizoma, Taxus wallichiana, Moringa oleifera, Vitex negundo, and many others) (Kuo et al. 2005a), scientists were successful in the discovery of anethol, allicin, catechins, curcumin, capsaicin, diallyl sulfide, ellagic acid, eugenol, genistein, lycopene, resveratrol, silymarin, S-allyl cysteine, 6-gingerol, ursolic acid, and other such compounds (Saumya et al. n.d.) with anti-cancerous properties. The discovery of anti-cancerous compounds met success when North American medicinal plants successfully completed clinical trials and were marketed for use. These plants were licensed for use in ovarian cancer (Taxus brevifolia), leukemia, lymphoma, and lung and testicular cancer (Podophyllum peltatum) (Gurib-Fakim 2006). Medicinal plants and their derivatives are effective, economical, and safe with negligible side effects (Hamayun et al. 2006b; Feng et al. 2005; Rahmawati et al. 2006). Furthermore, they are more accessible (Feng et al. 2005), have better compatibility (Kamboj 2000), and are highly acceptable (Feng et al. 2005; Ghimire et al. 2005) with respect to cultural, ethical, and historical issues. A thorough review of literature shows that countless medicinal plants have been exploited for their antitumor and anticancer potential. This chapter highlights some of the renowned anti-cancerous plants and the mechanism of action of their active constituents as expounded by research. The parts found to be effective for different ailments are summarized in Table 1.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Medicinal Plants Against Cancer","attachmentId":66090400,"attachmentType":"pdf","work_url":"https://www.academia.edu/45605431/Medicinal_Plants_Against_Cancer","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/45605431/Medicinal_Plants_Against_Cancer"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="37564986" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/37564986/2017_Antitumor_potential_of_someselective_medicinal_plants_on_experimental_tumor_ascitesl_pdf">2017-Antitumor potential of someselective medicinal plants on experimental tumor ascitesl.pdf</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="174532" href="https://tanta.academia.edu/ProfMohamedLabibSalem">Prof. Mohamed Labib Salem</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"2017-Antitumor potential of someselective medicinal plants on experimental tumor ascitesl.pdf","attachmentId":57542075,"attachmentType":"pdf","work_url":"https://www.academia.edu/37564986/2017_Antitumor_potential_of_someselective_medicinal_plants_on_experimental_tumor_ascitesl_pdf","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/37564986/2017_Antitumor_potential_of_someselective_medicinal_plants_on_experimental_tumor_ascitesl_pdf"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="106281123" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/106281123/ETHNOPHARMACOLOGICAL_EVALUATION_OF_MEDICINAL_PLANTS_FOR_CYTOTOXICITY_AGAINST_VARIOUS_CANCER_CELL_LINES_Original_Article">ETHNOPHARMACOLOGICAL EVALUATION OF MEDICINAL PLANTS FOR CYTOTOXICITY AGAINST VARIOUS CANCER CELL LINES Original Article</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="265496504" href="https://independent.academia.edu/InternationalJournalofPharmacyandPharmaceuticalSciencesIJPPS">International Journal of Pharmacy and Pharmaceutical Sciences (IJPPS)</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Pharmacy and Pharmaceutical Sciences, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective: To evaluate the cytotoxic potential of leaves and seeds of Hibiscus sabdariffa L., fruit juice of Phyllanthus emblica, rhizomes of Dryopteris cochleata and flowers of Caesalpinia decapetala (Roth) Alston along with the chemical profiling of the most toxic extract through Gas-mass spectroscopy-MS technique. Methods: The hydroalcoholic extract of the selected crude drugs was prepared by maceration method and the extracts were undergone through phytochemical analysis. The cytotoxic activity of the hydroalcoholic extract was performed against four cancer cell lines i.e. liver (HepG2), breast (MCF7), prostate (PC-3) and leukemia (HL60) using sulphorhodamine B assay. The hydroalcoholic extract of Caesalpinia decapetala flowers was profiled through using gas mass spectroscopy. Results: The results confirmed that Phyllanthus emblica inhibited HL60 cancer cells at the dose of 35.6 µg/ml and show dose-dependent growth inhibition. The flowers of Caesalpinia decapetala inhibited nearly fifty percent of HL60 cancer cells at very low dose i. e 10 µg/ml. The analysis of Caesalpinia decapetala flowers shows the presence of diterpenoid furanolactones, bufadienolides, polycyclic enones, and androsterone. Conclusion: The fruit juice of Phyllanthus emblica and flowers of Caesalpinia decapetala showed good inhibitory activity against HL60 cancer cell line. The use of Phyllanthus emblica in herbal medicine is justified. The data obtained impelled to further assess the in vivo efficacy of Caesalpinia decapetala flowers for anticancer activity.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"ETHNOPHARMACOLOGICAL EVALUATION OF MEDICINAL PLANTS FOR CYTOTOXICITY AGAINST VARIOUS CANCER CELL LINES Original Article","attachmentId":105520077,"attachmentType":"pdf","work_url":"https://www.academia.edu/106281123/ETHNOPHARMACOLOGICAL_EVALUATION_OF_MEDICINAL_PLANTS_FOR_CYTOTOXICITY_AGAINST_VARIOUS_CANCER_CELL_LINES_Original_Article","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/106281123/ETHNOPHARMACOLOGICAL_EVALUATION_OF_MEDICINAL_PLANTS_FOR_CYTOTOXICITY_AGAINST_VARIOUS_CANCER_CELL_LINES_Original_Article"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="95058594" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/95058594/Anticancer_activity_of_Medicinal_plant_extract_A_re_view">Anticancer activity of Medicinal plant extract-A re view</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="13713277" href="https://independent.academia.edu/SavitaDixit">Savita Dixit</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Traditional medicine has a long history of serving peoples all over the world. India is without doubt a herbal hub. Medicin al plants that are native to India and their use in various traditiona l systems of medicine are indeed awe-inspiring. The ethnobotany and ubiquitous plants provide a rich resource for Natural drug research a nd development. In recent years, the use of traditional medicine infor mation on plant research received considerable interest. The medici nal plants contain several phytochemicals such as vitamins, carotenoid s, terpenoids, flavonoids, polyphenols, alkaloids, tannins, saponi ns, enzymes, minerals etc. These phytochemicals possess antioxid ant activities, which, prevent or can be used in the treatment of m any diseases, including cancer. There are the several medicinal p lants all over the world, including India, which are being used tradit ionally for the prevention and treatment of cancer. The present pap er is a comprehensive review of different literat...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Anticancer activity of Medicinal plant extract-A re view","attachmentId":97345401,"attachmentType":"pdf","work_url":"https://www.academia.edu/95058594/Anticancer_activity_of_Medicinal_plant_extract_A_re_view","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/95058594/Anticancer_activity_of_Medicinal_plant_extract_A_re_view"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="33680287" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/33680287/A_Review_on_Medicinal_Plants_as_a_Potential_Source_for_Cancer_pdf">A Review on Medicinal Plants as a Potential Source for Cancer.pdf</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5240453" href="https://svuniversity.academia.edu/PulicherlaYugandhar">Pulicherla Yugandhar</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Cancer is a major health problem in both developed and developing countries. Cancer is the second leading cause of death after cardiovascular disease. Due to high death rate associated with cancer and serious side effects of chemotherapy and radiation therapy, many cancer patients seek alternative and/or complementary methods of treatment. India, which are being used traditionally for the prevention and treatment of cancer. However, only few medicinal plants have attracted the interest of scientists to investigate the remedy for neoplasm (tumor or cancer). Hence, an attempt has been made to review some medicinal plants used to prove scientific validation for the prevention and treatment of cancer. This article considers 82 medicinal plants belonging to 46 families and information on the Botanical name, family name, parts used, experimental model and mechanism of action were presented. This article provides basic handful information for researchers who are interested to work on medicinal plants for innovation of active biological compounds that to work on cancer as a principle mechanism.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A Review on Medicinal Plants as a Potential Source for Cancer.pdf","attachmentId":53685338,"attachmentType":"pdf","work_url":"https://www.academia.edu/33680287/A_Review_on_Medicinal_Plants_as_a_Potential_Source_for_Cancer_pdf","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/33680287/A_Review_on_Medicinal_Plants_as_a_Potential_Source_for_Cancer_pdf"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="78573751" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/78573751/Antiproliferative_activity_of_plant_extracts_used_against_cancer_in_traditional_medicine">Antiproliferative activity of plant extracts used against cancer in traditional medicine</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3795155" href="https://asu-jo.academia.edu/wamidhtalib">wamidh talib</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Scientia pharmaceutica, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Forty four extracts from sixteen plants used traditionally as anticancer agents were evaluated in vitro for their antiproliferative activity against Hep-2, MCF-7, and Vero cell lines. Plants were fractionated using ethanol, methanol, chloroform, n-hexane, distilled water, and butanol. The antiproliferative activity was measured by MTT assay. TLC was used to identify active fractions. The apoptotic activity of active fractions was determined using TUNEL colorimetric assay. 20 of these extracts demonstrated significant antiproliferative activity against one or more of the cell lines. These extracts were prepared from Ononis hirta, Inula viscosa, Salvia pinardi, Verbascum sinaiticum and Ononis sicula. Methanol fractions of Ononis hirta (aerial parts) and Inula viscosa (flowers) were the most active fractions against MCF-7 cells with IC(50) of 27.96 and 15.78 Îg/ml respectively and they were less toxic against other cell lines. Other extracts showed lower activity against cancer cell li...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Antiproliferative activity of plant extracts used against cancer in traditional medicine","attachmentId":85785926,"attachmentType":"pdf","work_url":"https://www.academia.edu/78573751/Antiproliferative_activity_of_plant_extracts_used_against_cancer_in_traditional_medicine","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/78573751/Antiproliferative_activity_of_plant_extracts_used_against_cancer_in_traditional_medicine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":49230780,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":49230780,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_49230780" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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