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class="u-tcGrayDarker" href="https://tanta.academia.edu/">Tanta University</a>, <a class="u-tcGrayDarker" href="https://tanta.academia.edu/Departments/New_Tanta_University_Teaching_Hospital/Documents">New Tanta University Teaching Hospital</a>, <span class="u-tcGrayDarker">Adjunct</span></div><div><a class="u-tcGrayDarker" href="https://tanta.academia.edu/">Tanta University</a>, <a class="u-tcGrayDarker" href="https://tanta.academia.edu/Departments/Immunology_and_Biotechnology_Division_Zoology/Documents">Immunology and Biotechnology Division, Zoology</a>, <span class="u-tcGrayDarker">Faculty Member</span></div><div><a class="u-tcGrayDarker" href="https://kyushu-u.academia.edu/">Kyushu University</a>, <a class="u-tcGrayDarker" href="https://kyushu-u.academia.edu/Departments/Medical_Institute_of_Bioregulation/Documents">Medical Institute of Bioregulation</a>, <span class="u-tcGrayDarker">Alumnus</span></div><div><a class="u-tcGrayDarker" href="https://musc.academia.edu/">Medical University of South Carolina</a>, <a class="u-tcGrayDarker" href="https://musc.academia.edu/Departments/Surgery/Documents">Surgery</a>, <span class="u-tcGrayDarker">Emeritus</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Prof. Mohamed" data-follow-user-id="174532" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="174532"><span class="material-symbols-outlined" style="font-size: 20px" 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class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">Prof. Salem (PhD, 1995) is the Prof. of Immunology at Tanta University, Egypt. Dr. Salem is the Founder and Director of the Center of Excellence in Cancer Research, Tanta University, Egypt; Founder, and Chairman of the Egyptian Association for Cancer Research. He is among the founding members of the Middle Eastern Association for Cancer Research, Canada. Dr. Salem is the General Supervisor of Delta Development Research Center, Academy of Scientific Research and Technology, Egypt; Ex-Director of the Grant, Innovation & Technology Transfer Center; Member of the Executive Board of Directors, Zewail City, Supervision Board Committee, New Egyptian Community Universities; Scientific Advisor to Galala University and Regional Development Center, Academy of Scientific Research and Technology, Egypt. He was Visiting Prof at the Medical University of South Carolina, USA.<br />Dr. Salem awarded Obada-prize for Distinguished Researcher, endowed by the African Academy of Sciences and the Natural Sciences Publishing, USA. April 2021. He also Khalifa Education Award for Distinguished University Professor in Research in Arab Countries (2020); Tanta University Award for Excellence in Research (2020); The State Medal of Science and Arts of the first class, President of Egypt, 2019; the State Esteemed Award in Basic Sciences (2018); State Excellence Award in Basic Sciences (2009); State Encouraging Award in Biology (2003), Academy of Scientific Research and Technology, Egypt. He also won Tanta University Esteemed Award, Tanta University, Egypt (2015). <br />Dr. Salem obtained his BSc (Zoology) in 1984, his MSc (Comparative Vertebrate Anatomy), in 1989, and PhD (Immunology) in 1995 from the Faculty of Science, Tanta University, Egypt. He was appointed as Demonstrator in 1984, Assistant Lecturer in 1989, and Lecturer in 1996 at Zoology Department, Faculty of Science, Tanta University. He obtained a PhD grant from Egypt (Channel System) to study Immunology Department, Kyushu University, Japan from 10/1992-1/1995 and a Japanese Postdoctoral Fellowship at the same department from 10/1997-3/2001. He worked as an Ass. Prof. from 2001-2010 at Surgery Department, Hollings Cancer Center, Medical University of South Carolina, USA. <br />Dr. Salem is a fellow of the World Academy of Medical Sciences (WAMS), a member of the WAMS Int. Scientific Council, and Chair of the WAMS Int. Board of Immunology, WAMS, The Netherlands. He is a member of several national committees including the National Committee for Professorship Promotion, National Committee for the Biological Sciences, National Committee for Scientific Research Strategies, National Committee for Basic Sciences Sector, Supreme Council of the Egyptian Universities, and Council of Basic Science Sector, Academy of Scientific Research and Technology, Egypt. He is a member of several editorial boards of peer-reviewed journals as well as ad hoc reviewers for more than 80 journals.<br />Dr. Salem's h-index is 33 and published 172 research articles in peer-reviewed journals and attended more than 100 national and international conferences. He supervised more than 80 Master's and PhD students. He was invited to give scientific talks (90 talks) in Egypt, UAE, Jordan, Saudi Arabia, USA, China and Canada. Dr. Salem’s research focuses on understanding the cellular and molecular mechanisms underlying how cancer escapes from host immunity, in particular the rules of the immunosuppressive cells including lymphoid and myeloid lineages as well as developing effective anticancer immunotherapy strategies. His research projects have been funded by the National Institute of Health, USA; European Union, Science and Technology Development Fund (STDF), Egypt, USA National Academy of Sciences, Tanta University, Egypt, private foundation and industry.<br /><span class="u-fw700">Phone: </span>0174272624<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/%D9%85%D8%AD%D9%85%D8%AF%D8%B9%D9%84%D9%8A%D9%85%D9%83%D9%8A"><img class="profile-avatar u-positionAbsolute" alt="محمد علي مكي" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = 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data-click-track="profile-works-tab" data-section-name="Drafts" data-toggle="tab" href="#drafts" role="tab" style="border: none;"><span>2</span> Drafts</a></li></ul></li></ul></div><div class="divider ds-divider-16" style="margin: 0px;"></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Books" id="Books"><h3 class="profile--tab_heading_container">Books by Prof. Mohamed Labib Salem</h3></div><div class="js-work-strip profile--work_container" data-work-id="121084925"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121084925/Book_Basic_Concepts_in_the_Philosophy_of_Science_Chapter"><img alt="Research paper thumbnail of Book Basic Concepts in the Philosophy of Science-Chapter" class="work-thumbnail" src="https://attachments.academia-assets.com/116058668/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121084925/Book_Basic_Concepts_in_the_Philosophy_of_Science_Chapter">Book Basic Concepts in the Philosophy of Science-Chapter</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The objective of science is to find out the character, properties, and the laws governing the var...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The objective of science is to find out the character, properties,<br />and the laws governing the various things and phenomena that<br />we see in the natural world. Scientific research concerns the act<br />of knowingwhat mankind does not know yet. And science follows<br />very definite methods in trying to know what is yet unknown.<br />In the past various approaches have been proposed for finding<br />out the answers to the questionswe have about various events<br />and things. Some of these have proved to be useful, and some<br />have led people astray. Finally, after much trial and error, after<br />much groping in the dark, after many successes and failures,<br />science has found the proper methodological approach to find<br />truth about nature. This is what constitutes the philosophy of<br />science.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dc10c83753ae8beb5cc0444041ecc3c3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116058668,"asset_id":121084925,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116058668/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121084925"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121084925"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121084925; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121084925]").text(description); $(".js-view-count[data-work-id=121084925]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121084925; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121084925']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121084903"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121084903/BASIC_CONCEPTS_IN_HISTORY_AND_PHILOSOPHY_OF_SCIENCE"><img alt="Research paper thumbnail of BASIC CONCEPTS IN HISTORY AND PHILOSOPHY OF SCIENCE" class="work-thumbnail" src="https://attachments.academia-assets.com/116058606/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121084903/BASIC_CONCEPTS_IN_HISTORY_AND_PHILOSOPHY_OF_SCIENCE">BASIC CONCEPTS IN HISTORY AND PHILOSOPHY OF SCIENCE</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This section intends to present a conceptual analysis of basic terms in the history and philosoph...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This section intends to present a conceptual analysis of basic terms in the history and philosophy of science. The history and philosophy of science is a study of the gradual development of the entire series of human activities which has culminated in what is now termed science. As can be seen and expected, the terms, “History”, Philosophy” and “Science”, stare us in the face begging for explanations. We shall, therefore, analyze these terms in their nuances and ramifications. The question of science, what science is and what it exists for will be presented. There will be an attempt to analyze “scientific method” and distinguish it from “scientific technique”. The features and goals of science will also be discussed here. The notions of facts, hypothesis, scientific theory and scientific law will be briefly explained. With an analysis on the scientific method, we shall realize that the scientific process involves inductive reasoning in the most part and a quantum of deduction. There will be a cursory explanation of the nature and place of philosophy of science.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="246ad7ab2a73ee3f9c887f022bcb3953" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116058606,"asset_id":121084903,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116058606/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121084903"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121084903"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121084903; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121084810"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121084810/Arab_science_in_the_golden_age_750_1258_C_E_and_today"><img alt="Research paper thumbnail of Arab science in the golden age (750 -1258 C.E.) and today" class="work-thumbnail" src="https://attachments.academia-assets.com/116058569/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121084810/Arab_science_in_the_golden_age_750_1258_C_E_and_today">Arab science in the golden age (750 -1258 C.E.) and today</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Arab world covers a vast geographic area, comprising many different countries in Asia and Afr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Arab world covers a vast geographic area, comprising many different countries in Asia and Africa. The contemporary world owes much of its progress in all fields of human intellectual activity, including medicine, to Arabic culture, especially the advancements made during the Golden Age of Arabic-Islamic science (8th to 13th centuries C.E.). The glorious historic background of the Arabic world permits us to identify the debt that humanity owes to the Golden Age of Arabic science and to evaluate the research contributions made by Arab countries to biomedical sciences in our own day.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4676271c0381fd2bc1f2d39afee575cf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116058569,"asset_id":121084810,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116058569/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121084810"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121084810"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121084810; 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It will provide you with insightful tips, and easy steps that you can<br />follow to solve problems efficiently. The tips presented in this book aren’t<br />restricted to just one scenario and can be made use of in every aspect of life.<br />Critical thinking is the ability to think objectively and rationally about a<br />particular situation without letting your emotions rule you. This is an<br />important skill that’s quite important in life if you want to be successful. Like any other skill, this one can be easily learned! All it needs is a little bit of practice and patience.<br /><br />In this book, you will learn about critical thinking, the skills essential for<br />critical thinking, strategies for better decision-making, and you will find tips for problem solving, and the learn the strategies needed for setting goals. The tips and various strategies mentioned in this book are not only easy to understand but can be followed quite easily as well. Let us get started without any further ado.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e031402920b6ccd11639b65ab3fad781" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115417176,"asset_id":120183776,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115417176/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120183776"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120183776"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120183776; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="118350835"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/118350835/%D9%85%D8%AC%D9%85%D9%88%D8%B9%D8%A9_%D9%82%D8%B5%D8%B5%D9%8A%D8%A9_%D9%85%D8%B4%D8%A7%D8%B9%D8%B1_%D8%A2%D9%8A%D9%84%D8%A9_%D9%84%D9%84%D8%B3%D9%82%D9%88%D8%B7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8"><img alt="Research paper thumbnail of مجموعة قصصية مشاعر آيلة للسقوط د. محمد لبيب" class="work-thumbnail" src="https://attachments.academia-assets.com/113998499/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/118350835/%D9%85%D8%AC%D9%85%D9%88%D8%B9%D8%A9_%D9%82%D8%B5%D8%B5%D9%8A%D8%A9_%D9%85%D8%B4%D8%A7%D8%B9%D8%B1_%D8%A2%D9%8A%D9%84%D8%A9_%D9%84%D9%84%D8%B3%D9%82%D9%88%D8%B7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8">مجموعة قصصية مشاعر آيلة للسقوط د. محمد لبيب</a></div><div class="wp-workCard_item"><span> مشاعر آيلة للسقوط - مجموعة قصصية</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">المشاعر الطيبة لغة القلوب وأبخرة العقول برائحة العنبر والمسك، وكلما تأججت نيران المشاعر ازداد تصا...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">المشاعر الطيبة لغة القلوب وأبخرة العقول برائحة العنبر والمسك، وكلما تأججت نيران المشاعر ازداد تصاعد أبخرة الأحاسيس الحُلوة من العقل وَرَقَّ القلب. ولكن هناك من المشاعر ما تظل تتأجج حتى تنضب شعلتها؛ فتخفت رويدًا رويدًا حتى تصير آيلة للسقوط، وتصبح من الذكريات ويحترق القلب. ولكن قد تتعافى المشاعر فجأة وتشتعل جذوة الأحاسيس الحُلوة مرة أخرى بفضل كلمة حب من أحدهم، أو اهتمام، أو نظرة بعيون حانية دامعة؛ أو قد تستمر في طريقها للسقوط كما تسقط أوراق الأشجار في الخريف. <br />وهكذا تحيا القلوب الرقيقة التي تبحث دائما عن يد تكفكف عليها أو كلمة تطبطب عليها. وعن تلك القلوب وعن تلك المشاعر تدور هذه المجموعة القصصية التي قد تجد نفسك فيها هنا أو هناك محاولا أن تمنع مشاعرك من السقوط</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ce97264e10135d8ca23fc723fa8a1cd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113998499,"asset_id":118350835,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113998499/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="118350835"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="118350835"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 118350835; 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He i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Prof. Salem (Ph.D.) is the Prof. of Immunology, Faculty of Science, Tanta University, Egypt. He is an outstanding scholar in Immunology and Cancer Immunology based on his cutting-edge research in the USA, Japan, and Egypt. His main discoveries in the preclinical settings have been translated into clinics. Prof. Salem is the founding director of the Center of Excellence in Cancer Research, at Tanta University, President of the Egyptian Association of Cancer Research, Egypt. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37564927"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37564927/Administration_of_olive_oil_optimizes_the_acetic_acid_induced_colitis_in_CD1_mice"><img alt="Research paper thumbnail of Administration of olive oil optimizes the acetic acid-induced colitis in CD1 mice" class="work-thumbnail" src="https://attachments.academia-assets.com/57542026/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37564927/Administration_of_olive_oil_optimizes_the_acetic_acid_induced_colitis_in_CD1_mice">Administration of olive oil optimizes the acetic acid-induced colitis in CD1 mice</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ARTICLE INFO Administration of olive oil optimizes the acetic acid induced colitis in CD1 mice, S...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ARTICLE INFO Administration of olive oil optimizes the acetic acid induced colitis in CD1 mice, Salem et al., 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f0071bfb5cfd82df2ed7c8a65aced463" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57542026,"asset_id":37564927,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57542026/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37564927"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37564927"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37564927; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=37564927]").text(description); $(".js-view-count[data-work-id=37564927]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 37564927; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='37564927']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f0071bfb5cfd82df2ed7c8a65aced463" } } $('.js-work-strip[data-work-id=37564927]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":37564927,"title":"Administration of olive oil optimizes the acetic acid-induced colitis in CD1 mice","internal_url":"https://www.academia.edu/37564927/Administration_of_olive_oil_optimizes_the_acetic_acid_induced_colitis_in_CD1_mice","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":57542026,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/57542026/thumbnails/1.jpg","file_name":"2018_JCBR-Administration_of_olive_oil_optimizes_the_acetic_acid-induced_colitis_in_CD1_mice.pdf","download_url":"https://www.academia.edu/attachments/57542026/download_file","bulk_download_file_name":"Administration_of_olive_oil_optimizes_th.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/57542026/2018_JCBR-Administration_of_olive_oil_optimizes_the_acetic_acid-induced_colitis_in_CD1_mice-libre.pdf?1539215109=\u0026response-content-disposition=attachment%3B+filename%3DAdministration_of_olive_oil_optimizes_th.pdf\u0026Expires=1739893515\u0026Signature=KnArY4kunMcgBCxHU7lUWXoI-p1XlExscCLEfi8aooUUiAoGgMRNmRRuyudvk4EilBd5OF8DkrssfSEVJctn9hOo~6KE507nb1JXsFljhcEwWe4i72LTLJSMDvz4Ds7ur3kLsg7cixfAnluTFcf92nqlZzSE9oZG-lkJMenwvQ5dLy6uLnnWlLEkLW8pcV9EA0sREwQ073LjwbfMYScYp8o4LI9mlYGSpiVhgsXLo6nG97~YFKYII8lYVQI1v2lCpCQ07PB5WcivjWDtebGjIoMY8xxpM8yLPrBMXP9C0wIt8yydBaP5u9Bzzoyd3CtKG5i5B0vhAYhPypU5lxeH7g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37564424"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37564424/Fibroblast_growth_factor_2_decreases_bleomycin_induced_pulmonary_fibrosis_and_inhibits_fibroblast_collagen_production_and_myofibroblast_differentiation"><img alt="Research paper thumbnail of Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation" class="work-thumbnail" src="https://attachments.academia-assets.com/57541450/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37564424/Fibroblast_growth_factor_2_decreases_bleomycin_induced_pulmonary_fibrosis_and_inhibits_fibroblast_collagen_production_and_myofibroblast_differentiation">Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fibroblast growth factor (FGF) signaling has been implicated in the pathogenesis of pulmonary fib...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fibroblast growth factor (FGF) signaling has been implicated in the pathogenesis of pulmonary fibrosis. Mice lacking FGF2 have increased mortality and impaired epithelial recovery after bleomycin exposure, supporting a protective or reparative function following lung injury. To determine whether FGF2 overexpression reduces bleomycin-induced injury, we developed an inducible genetic system to express FGF2 in type II pneumocytes. Double-transgenic (DTG) mice with doxycycline-inducible overexpression of human FGF2 (SPC-rtTA;TRE-hFGF2) or single-transgenic controls were administered intratracheal bleomycin and fed doxycycline chow, starting at either day 0 or day 7. In addition, wild-type mice received intratracheal or intravenous recombinant FGF2, starting at the time of bleomycin treatment. Compared to controls, doxycycline-induced DTG mice had decreased pulmonary fibrosis 21 days after bleomycin, as assessed by gene expression and histology. This beneficial effect was seen when FGF2 overexpression was induced at day 0 or day 7 after bleomycin. FGF2 overexpression did not alter epithelial gene expression, bronchoalveolar lavage cellularity or total protein. In vitro studies using primary mouse and human lung fibroblasts showed that FGF2 strongly inhibited baseline and TGF1-induced expression of alpha smooth muscle actin (SMA), collagen, and connective tissue growth factor. While FGF2 did not suppress phosphorylation of Smad2 or Smad-dependent gene expression, FGF2 inhibited TGF1-induced stress fiber formation and serum response factor-dependent gene expression. FGF2 inhibition of stress fiber formation and SMA requires FGF receptor 1 (FGFR1) and downstream MEK/ERK, but not AKT signaling. In summary, overexpression of FGF2 protects against bleomycin-induced pulmonary fibrosis in vivo and reverses TGF1-induced collagen and SMA expression and stress fiber formation in lung fibroblasts in vitro, without affecting either inflammation or epithelial gene expression. Our results suggest that in the lung, FGF2 is antifibrotic in part through decreased collagen expression and fibroblast to myofibroblast differentiation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="47b4df8425a03ab9328217433d1ed737" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57541450,"asset_id":37564424,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57541450/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37564424"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37564424"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37564424; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=37564424]").text(description); $(".js-view-count[data-work-id=37564424]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 37564424; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='37564424']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "47b4df8425a03ab9328217433d1ed737" } } $('.js-work-strip[data-work-id=37564424]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":37564424,"title":"Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation","internal_url":"https://www.academia.edu/37564424/Fibroblast_growth_factor_2_decreases_bleomycin_induced_pulmonary_fibrosis_and_inhibits_fibroblast_collagen_production_and_myofibroblast_differentiation","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":57541450,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/57541450/thumbnails/1.jpg","file_name":"2018-J_Pathology_Fibroblast_growth_factor_2_decreases_bleomycin-induced_pulmonary_fibrosis_and_inhibits.pdf","download_url":"https://www.academia.edu/attachments/57541450/download_file","bulk_download_file_name":"Fibroblast_growth_factor_2_decreases_ble.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/57541450/2018-J_Pathology_Fibroblast_growth_factor_2_decreases_bleomycin-induced_pulmonary_fibrosis_and_inhibits-libre.pdf?1539204053=\u0026response-content-disposition=attachment%3B+filename%3DFibroblast_growth_factor_2_decreases_ble.pdf\u0026Expires=1739893515\u0026Signature=UrR49RtCAWMAJzbFl7Xz9FKOjgOVgiPS8rtM5ZujkxU1nmsDqvRshzSLA9IfGpN~-LOAg7cuuDvF1gT5k4o6W6vpGVUSGRe2bUSOJZlfMcD-OA7iKlYlz7IeL8yWyiief1YVRBFDfMp8nZhfu1eJnvXGk6Dsh7Pv0vKe1HVYROR71tR7Alt4UwQHaWmcCqPsOwHDeFcmouhXwNrqEGZGE2Lu8pUnXPFHk-dzN-a3bIC6LF7hXZjWorF1PZWCL57sAeONA5aTwLj8~LIHm9dc2lxK~Y7CkbEdSo2qLpoXIBgmAqJit2KDXWGPmewx8fFSv6wsNFQTIoIViCTcX5BnGg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37564423"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37564423/Comparative_expression_of_caspases_and_annexin_V_in_benign_and_malignant_ovarian_tumors"><img alt="Research paper thumbnail of Comparative expression of caspases and annexin V in benign and malignant ovarian tumors" class="work-thumbnail" src="https://attachments.academia-assets.com/57541442/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37564423/Comparative_expression_of_caspases_and_annexin_V_in_benign_and_malignant_ovarian_tumors">Comparative expression of caspases and annexin V in benign and malignant ovarian tumors</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim of Study: Ovarian cancer (OC) leads to high mortality rate if diagnosed at late stage. The ai...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim of Study: Ovarian cancer (OC) leads to high mortality rate if diagnosed at late stage. The aim of the present study was to increase the survival rate by early disease diagnosis. Materials and Methods: A total of 21 females were divided into three groups. The control (n = 3), benign (n = 8), and malignant group (n = 10). We used flow cytometry to analyze cell cycle, caspase‑3, ‑8, and annexin V. Results: The results showed that the annexin V expressed in malignant group more than benign and normal groups with (P = 0.000 and P = 0.007), respectively. Caspase‑3 and 8 expression decreased in benign and malignant group than in normal group (P = 0.012 and P = 0.007), respectively. Furthermore, sub‑G1 apoptosis level decreased statistically significant in benign and malignant group than in normal group (P = 0.012 and P = 0.007), respectively. These data showed that (S phase) level had statistically significant increase in malignant group (P = 0.007) than the control group and marked statistically significant decrease (P = 0.000) in benign group than malignant group. This study explained changes in sub‑G1 apoptosis for benign group increase statistically significant (P = 0.003) than malignant group level. Conclusion: Caspase‑3 and ‑8 and annexin V may serve as diagnostic markers in OC, also explained that the decrement in control of the S phase in the cell cycle may considered one of the significant factors in the development of ovarian tumors.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9786df335f365baafed7bc38fb0eb20a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57541442,"asset_id":37564423,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57541442/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37564423"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37564423"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37564423; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=37564423]").text(description); $(".js-view-count[data-work-id=37564423]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 37564423; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='37564423']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37564422"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37564422/2018_JDI_Stem_cell_therapy_as_a_novel_therapeutic_intervention_for_alopecia_pdf"><img alt="Research paper thumbnail of 2018-JDI-Stem cell therapy as a novel therapeutic intervention for alopecia.pdf" class="work-thumbnail" src="https://attachments.academia-assets.com/57540719/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37564422/2018_JDI_Stem_cell_therapy_as_a_novel_therapeutic_intervention_for_alopecia_pdf">2018-JDI-Stem cell therapy as a novel therapeutic intervention for alopecia.pdf</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Management of alopecia areata (AA) and androgenetic alopecia (AGA) is often challengi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Management of alopecia areata (AA) and androgenetic alopecia (AGA) is often challenging as patients may be resistant to currently available modalities of treatment. The use of stem cells may be a novel option for resistant cases. Objective: To evaluate the safety and efficacy of the use of autologous bone marrow derived mono-nuclear cells (including stem cells) as compared to follicular stems cells for the management of resistant cases of AA and AGA. Methods: This study included 40 patients (20 AA patients and 20 AGA patients), all patients were treated with a single session of intradermal injection of autologous stem cells (SCs) therapy. They were divided into four groups according to the applied modality [either autologous bone marrow derived mononuclear cells (bone marrow mononuclear cells [BMMCs] or autologous follicular stem cells [FSC]). Results: Six months after stem cell therapy (SCT) injection, there was a significant improvement, confirmed by immunostaining and digital dermoscopy. The mean improvement in all groups was " very good ". There was no significant difference between both methods in either type of alopecia. No serious adverse events were reported. Conclusion: Autologous BMMCs and FSC seem to be a safe tolerable and effective treatment for the management of both resistant AA and AGA.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="34c6a7b42358c5f08900dbca324b07d7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57540719,"asset_id":37564422,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57540719/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37564422"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37564422"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37564422; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37559333"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37559333/2018_OncologyLetter_A_novel_strategy_for_enhancing_the_antitumor_immunity_in_breast_cancer_patients_pdf"><img alt="Research paper thumbnail of 2018-OncologyLetter_A novel strategy for enhancing the antitumor immunity in breast cancer patients.pdf" class="work-thumbnail" src="https://attachments.academia-assets.com/57535989/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37559333/2018_OncologyLetter_A_novel_strategy_for_enhancing_the_antitumor_immunity_in_breast_cancer_patients_pdf">2018-OncologyLetter_A novel strategy for enhancing the antitumor immunity in breast cancer patients.pdf</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dendritic cells (DCs) have been used in a number of clinical trials for cancer immunotherapy; how...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dendritic cells (DCs) have been used in a number of clinical trials for cancer immunotherapy; however, they have achieved limited success in solid tumors. Consequently the aim of the present study was to identify a novel potential immunotherapeutic target for breast cancer patients through in vitro optimization of a viable DC-based vaccine. Immature DCs were primed by viable MCF-7 breast cancer cells and the activity and maturation of DCs were assessed through measuring CD83, CD86 and major histocompatibility complex (MHC)-II expression, in addition to different T cell subpopu-lations, namely CD4 + T cells, CD8 + T cells, and CD4 + CD25 + forkhead box protein 3 (Foxp3) + regulatory T cells (Tregs), by flow cytometric analysis. Foxp3 level was also measured by enzyme-linked immunosorbent assay (ELISA) in addition to reverse-transcription quantitative polymerase chain reaction. The levels of interleukin-12 (IL-12) and interferon-γ (IFN-γ) were determined by ELISA. Finally, the cytotoxicity of cytotoxic T lymphocytes (CTLs) was evaluated through measuring lactate dehydrogenase (LDH) release by ELISA. The results demonstrated that CD83 + , CD86 + and MHC-II + DCs were significantly elevated (P<0.001) following priming with breast cancer cells. In addition, there was increased activation of CD4 + and CD8 + T‑cells, with a significant decrease of CD4 + CD25 + Foxp3 + Tregs (P<0.001). Furthermore, a significant downregulation of FOXP3 gene expression (P<0.001) was identified, and a significant decrease in the level of its protein following activation (P<0.001) was demonstrated by ELISA. Additionally, significant increases in the secretion of IL‑12 and IFN-γ (P= 0.001) were observed. LDH release was significantly increased (P<0.001), indicating a marked cytotoxicity of CTLs against cancer cells. Therefore viable breast cancer cell-DC-based vaccines could expose an innovative avenue for a novel breast cancer immunotherapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3e8b37c643cd6c32a459e2ff5978ef8c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57535989,"asset_id":37559333,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57535989/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37559333"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37559333"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37559333; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="196648" id="books"><div class="js-work-strip profile--work_container" data-work-id="121084925"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121084925/Book_Basic_Concepts_in_the_Philosophy_of_Science_Chapter"><img alt="Research paper thumbnail of Book Basic Concepts in the Philosophy of Science-Chapter" class="work-thumbnail" src="https://attachments.academia-assets.com/116058668/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121084925/Book_Basic_Concepts_in_the_Philosophy_of_Science_Chapter">Book Basic Concepts in the Philosophy of Science-Chapter</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The objective of science is to find out the character, properties, and the laws governing the var...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The objective of science is to find out the character, properties,<br />and the laws governing the various things and phenomena that<br />we see in the natural world. Scientific research concerns the act<br />of knowingwhat mankind does not know yet. And science follows<br />very definite methods in trying to know what is yet unknown.<br />In the past various approaches have been proposed for finding<br />out the answers to the questionswe have about various events<br />and things. Some of these have proved to be useful, and some<br />have led people astray. Finally, after much trial and error, after<br />much groping in the dark, after many successes and failures,<br />science has found the proper methodological approach to find<br />truth about nature. This is what constitutes the philosophy of<br />science.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dc10c83753ae8beb5cc0444041ecc3c3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116058668,"asset_id":121084925,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116058668/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121084925"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121084925"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121084925; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dc10c83753ae8beb5cc0444041ecc3c3" } } $('.js-work-strip[data-work-id=121084925]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121084925,"title":"Book Basic Concepts in the Philosophy of Science-Chapter","internal_url":"https://www.academia.edu/121084925/Book_Basic_Concepts_in_the_Philosophy_of_Science_Chapter","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":116058668,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116058668/thumbnails/1.jpg","file_name":"Book_Basic_Concepts_in_the_Philosophy_of_Science_Chapter_1.pdf","download_url":"https://www.academia.edu/attachments/116058668/download_file","bulk_download_file_name":"Book_Basic_Concepts_in_the_Philosophy_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116058668/Book_Basic_Concepts_in_the_Philosophy_of_Science_Chapter_1-libre.pdf?1718540785=\u0026response-content-disposition=attachment%3B+filename%3DBook_Basic_Concepts_in_the_Philosophy_of.pdf\u0026Expires=1739931653\u0026Signature=S~luHL80dV10ZMDw1DkDdwmuTdShk7JBLPoYgXzAJYoNf1JF9L6CexDciIEx4NXjaKA0o9j2H9CvQK8lDO8tfpYV3ZMaVaYdXVMJ8hEFt1MLY8hIRA7TVyoK~3RfzGe6CnVeCb-MKW07vqUy7LV5uXyZZRpfI50DPA~HNSSjXM~yxfJN6Cn3mZ0LZgsC1X6I8wCMzTzfJn6suZALrkWKRr1psqW~iKG8A8q4e3yI8ryobyygMz4OjGhGQ4LRb~1yPjiADWsMKPJrg2hAfu-J9U-POhL7owr-FEl-2EQxFp-vnp7Lzn5bw6q2JNBGOpRVnTJYqxGBX-TlRbRFT49uSQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121084903"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121084903/BASIC_CONCEPTS_IN_HISTORY_AND_PHILOSOPHY_OF_SCIENCE"><img alt="Research paper thumbnail of BASIC CONCEPTS IN HISTORY AND PHILOSOPHY OF SCIENCE" class="work-thumbnail" src="https://attachments.academia-assets.com/116058606/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121084903/BASIC_CONCEPTS_IN_HISTORY_AND_PHILOSOPHY_OF_SCIENCE">BASIC CONCEPTS IN HISTORY AND PHILOSOPHY OF SCIENCE</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This section intends to present a conceptual analysis of basic terms in the history and philosoph...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This section intends to present a conceptual analysis of basic terms in the history and philosophy of science. The history and philosophy of science is a study of the gradual development of the entire series of human activities which has culminated in what is now termed science. As can be seen and expected, the terms, “History”, Philosophy” and “Science”, stare us in the face begging for explanations. We shall, therefore, analyze these terms in their nuances and ramifications. The question of science, what science is and what it exists for will be presented. There will be an attempt to analyze “scientific method” and distinguish it from “scientific technique”. The features and goals of science will also be discussed here. The notions of facts, hypothesis, scientific theory and scientific law will be briefly explained. With an analysis on the scientific method, we shall realize that the scientific process involves inductive reasoning in the most part and a quantum of deduction. There will be a cursory explanation of the nature and place of philosophy of science.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="246ad7ab2a73ee3f9c887f022bcb3953" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116058606,"asset_id":121084903,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116058606/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121084903"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121084903"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121084903; 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The contemporary world owes much of its progress in all fields of human intellectual activity, including medicine, to Arabic culture, especially the advancements made during the Golden Age of Arabic-Islamic science (8th to 13th centuries C.E.). The glorious historic background of the Arabic world permits us to identify the debt that humanity owes to the Golden Age of Arabic science and to evaluate the research contributions made by Arab countries to biomedical sciences in our own day.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4676271c0381fd2bc1f2d39afee575cf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116058569,"asset_id":121084810,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116058569/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121084810"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121084810"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121084810; 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It will provide you with insightful tips, and easy steps that you can<br />follow to solve problems efficiently. The tips presented in this book aren’t<br />restricted to just one scenario and can be made use of in every aspect of life.<br />Critical thinking is the ability to think objectively and rationally about a<br />particular situation without letting your emotions rule you. This is an<br />important skill that’s quite important in life if you want to be successful. Like any other skill, this one can be easily learned! All it needs is a little bit of practice and patience.<br /><br />In this book, you will learn about critical thinking, the skills essential for<br />critical thinking, strategies for better decision-making, and you will find tips for problem solving, and the learn the strategies needed for setting goals. The tips and various strategies mentioned in this book are not only easy to understand but can be followed quite easily as well. Let us get started without any further ado.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e031402920b6ccd11639b65ab3fad781" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115417176,"asset_id":120183776,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115417176/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120183776"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120183776"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120183776; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="118350835"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/118350835/%D9%85%D8%AC%D9%85%D9%88%D8%B9%D8%A9_%D9%82%D8%B5%D8%B5%D9%8A%D8%A9_%D9%85%D8%B4%D8%A7%D8%B9%D8%B1_%D8%A2%D9%8A%D9%84%D8%A9_%D9%84%D9%84%D8%B3%D9%82%D9%88%D8%B7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8"><img alt="Research paper thumbnail of مجموعة قصصية مشاعر آيلة للسقوط د. محمد لبيب" class="work-thumbnail" src="https://attachments.academia-assets.com/113998499/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/118350835/%D9%85%D8%AC%D9%85%D9%88%D8%B9%D8%A9_%D9%82%D8%B5%D8%B5%D9%8A%D8%A9_%D9%85%D8%B4%D8%A7%D8%B9%D8%B1_%D8%A2%D9%8A%D9%84%D8%A9_%D9%84%D9%84%D8%B3%D9%82%D9%88%D8%B7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8">مجموعة قصصية مشاعر آيلة للسقوط د. محمد لبيب</a></div><div class="wp-workCard_item"><span> مشاعر آيلة للسقوط - مجموعة قصصية</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">المشاعر الطيبة لغة القلوب وأبخرة العقول برائحة العنبر والمسك، وكلما تأججت نيران المشاعر ازداد تصا...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">المشاعر الطيبة لغة القلوب وأبخرة العقول برائحة العنبر والمسك، وكلما تأججت نيران المشاعر ازداد تصاعد أبخرة الأحاسيس الحُلوة من العقل وَرَقَّ القلب. ولكن هناك من المشاعر ما تظل تتأجج حتى تنضب شعلتها؛ فتخفت رويدًا رويدًا حتى تصير آيلة للسقوط، وتصبح من الذكريات ويحترق القلب. ولكن قد تتعافى المشاعر فجأة وتشتعل جذوة الأحاسيس الحُلوة مرة أخرى بفضل كلمة حب من أحدهم، أو اهتمام، أو نظرة بعيون حانية دامعة؛ أو قد تستمر في طريقها للسقوط كما تسقط أوراق الأشجار في الخريف. <br />وهكذا تحيا القلوب الرقيقة التي تبحث دائما عن يد تكفكف عليها أو كلمة تطبطب عليها. وعن تلك القلوب وعن تلك المشاعر تدور هذه المجموعة القصصية التي قد تجد نفسك فيها هنا أو هناك محاولا أن تمنع مشاعرك من السقوط</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ce97264e10135d8ca23fc723fa8a1cd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113998499,"asset_id":118350835,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113998499/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="118350835"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="118350835"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 118350835; 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He i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Prof. Salem (Ph.D.) is the Prof. of Immunology, Faculty of Science, Tanta University, Egypt. He is an outstanding scholar in Immunology and Cancer Immunology based on his cutting-edge research in the USA, Japan, and Egypt. His main discoveries in the preclinical settings have been translated into clinics. Prof. Salem is the founding director of the Center of Excellence in Cancer Research, at Tanta University, President of the Egyptian Association of Cancer Research, Egypt. 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Mice lacking FGF2 have increased mortality and impaired epithelial recovery after bleomycin exposure, supporting a protective or reparative function following lung injury. To determine whether FGF2 overexpression reduces bleomycin-induced injury, we developed an inducible genetic system to express FGF2 in type II pneumocytes. Double-transgenic (DTG) mice with doxycycline-inducible overexpression of human FGF2 (SPC-rtTA;TRE-hFGF2) or single-transgenic controls were administered intratracheal bleomycin and fed doxycycline chow, starting at either day 0 or day 7. In addition, wild-type mice received intratracheal or intravenous recombinant FGF2, starting at the time of bleomycin treatment. Compared to controls, doxycycline-induced DTG mice had decreased pulmonary fibrosis 21 days after bleomycin, as assessed by gene expression and histology. This beneficial effect was seen when FGF2 overexpression was induced at day 0 or day 7 after bleomycin. FGF2 overexpression did not alter epithelial gene expression, bronchoalveolar lavage cellularity or total protein. In vitro studies using primary mouse and human lung fibroblasts showed that FGF2 strongly inhibited baseline and TGF1-induced expression of alpha smooth muscle actin (SMA), collagen, and connective tissue growth factor. While FGF2 did not suppress phosphorylation of Smad2 or Smad-dependent gene expression, FGF2 inhibited TGF1-induced stress fiber formation and serum response factor-dependent gene expression. FGF2 inhibition of stress fiber formation and SMA requires FGF receptor 1 (FGFR1) and downstream MEK/ERK, but not AKT signaling. In summary, overexpression of FGF2 protects against bleomycin-induced pulmonary fibrosis in vivo and reverses TGF1-induced collagen and SMA expression and stress fiber formation in lung fibroblasts in vitro, without affecting either inflammation or epithelial gene expression. Our results suggest that in the lung, FGF2 is antifibrotic in part through decreased collagen expression and fibroblast to myofibroblast differentiation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="47b4df8425a03ab9328217433d1ed737" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57541450,"asset_id":37564424,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57541450/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37564424"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37564424"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37564424; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=37564424]").text(description); $(".js-view-count[data-work-id=37564424]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 37564424; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='37564424']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "47b4df8425a03ab9328217433d1ed737" } } $('.js-work-strip[data-work-id=37564424]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":37564424,"title":"Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation","internal_url":"https://www.academia.edu/37564424/Fibroblast_growth_factor_2_decreases_bleomycin_induced_pulmonary_fibrosis_and_inhibits_fibroblast_collagen_production_and_myofibroblast_differentiation","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":57541450,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/57541450/thumbnails/1.jpg","file_name":"2018-J_Pathology_Fibroblast_growth_factor_2_decreases_bleomycin-induced_pulmonary_fibrosis_and_inhibits.pdf","download_url":"https://www.academia.edu/attachments/57541450/download_file","bulk_download_file_name":"Fibroblast_growth_factor_2_decreases_ble.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/57541450/2018-J_Pathology_Fibroblast_growth_factor_2_decreases_bleomycin-induced_pulmonary_fibrosis_and_inhibits-libre.pdf?1539204053=\u0026response-content-disposition=attachment%3B+filename%3DFibroblast_growth_factor_2_decreases_ble.pdf\u0026Expires=1739893515\u0026Signature=UrR49RtCAWMAJzbFl7Xz9FKOjgOVgiPS8rtM5ZujkxU1nmsDqvRshzSLA9IfGpN~-LOAg7cuuDvF1gT5k4o6W6vpGVUSGRe2bUSOJZlfMcD-OA7iKlYlz7IeL8yWyiief1YVRBFDfMp8nZhfu1eJnvXGk6Dsh7Pv0vKe1HVYROR71tR7Alt4UwQHaWmcCqPsOwHDeFcmouhXwNrqEGZGE2Lu8pUnXPFHk-dzN-a3bIC6LF7hXZjWorF1PZWCL57sAeONA5aTwLj8~LIHm9dc2lxK~Y7CkbEdSo2qLpoXIBgmAqJit2KDXWGPmewx8fFSv6wsNFQTIoIViCTcX5BnGg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37564423"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37564423/Comparative_expression_of_caspases_and_annexin_V_in_benign_and_malignant_ovarian_tumors"><img alt="Research paper thumbnail of Comparative expression of caspases and annexin V in benign and malignant ovarian tumors" class="work-thumbnail" src="https://attachments.academia-assets.com/57541442/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37564423/Comparative_expression_of_caspases_and_annexin_V_in_benign_and_malignant_ovarian_tumors">Comparative expression of caspases and annexin V in benign and malignant ovarian tumors</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim of Study: Ovarian cancer (OC) leads to high mortality rate if diagnosed at late stage. The ai...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim of Study: Ovarian cancer (OC) leads to high mortality rate if diagnosed at late stage. The aim of the present study was to increase the survival rate by early disease diagnosis. Materials and Methods: A total of 21 females were divided into three groups. The control (n = 3), benign (n = 8), and malignant group (n = 10). We used flow cytometry to analyze cell cycle, caspase‑3, ‑8, and annexin V. Results: The results showed that the annexin V expressed in malignant group more than benign and normal groups with (P = 0.000 and P = 0.007), respectively. Caspase‑3 and 8 expression decreased in benign and malignant group than in normal group (P = 0.012 and P = 0.007), respectively. Furthermore, sub‑G1 apoptosis level decreased statistically significant in benign and malignant group than in normal group (P = 0.012 and P = 0.007), respectively. These data showed that (S phase) level had statistically significant increase in malignant group (P = 0.007) than the control group and marked statistically significant decrease (P = 0.000) in benign group than malignant group. This study explained changes in sub‑G1 apoptosis for benign group increase statistically significant (P = 0.003) than malignant group level. Conclusion: Caspase‑3 and ‑8 and annexin V may serve as diagnostic markers in OC, also explained that the decrement in control of the S phase in the cell cycle may considered one of the significant factors in the development of ovarian tumors.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9786df335f365baafed7bc38fb0eb20a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57541442,"asset_id":37564423,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57541442/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37564423"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37564423"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37564423; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=37564423]").text(description); $(".js-view-count[data-work-id=37564423]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 37564423; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='37564423']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9786df335f365baafed7bc38fb0eb20a" } } $('.js-work-strip[data-work-id=37564423]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":37564423,"title":"Comparative expression of caspases and annexin V in benign and malignant ovarian tumors","internal_url":"https://www.academia.edu/37564423/Comparative_expression_of_caspases_and_annexin_V_in_benign_and_malignant_ovarian_tumors","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":57541442,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/57541442/thumbnails/1.jpg","file_name":"2018-JCanResTher-Comparative_expression_of_annexin_V_...pdf","download_url":"https://www.academia.edu/attachments/57541442/download_file","bulk_download_file_name":"Comparative_expression_of_caspases_and_a.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/57541442/2018-JCanResTher-Comparative_expression_of_annexin_V_..-libre.pdf?1539204061=\u0026response-content-disposition=attachment%3B+filename%3DComparative_expression_of_caspases_and_a.pdf\u0026Expires=1739931653\u0026Signature=RY3LLtARDJxdC77qaKXGuj8~s4EnqnxXR27aGHOSuDXidycBPjMbnZmY0x0KUOaesVrBV220aCYA4WCYRin5sx5XwziZRDLLoCQfQENvzycpVp-cjWuYgKy6jcAdegShFCGi2b8mt~W2MqWZubHPkyHzrHOZbeTMKz9mD9pbb0YVbsjqEqqniQHtYC4KRfnENGP5flu40TenDWnRl2rJmOk3jKzBoWlDRgcvF5Ch4g~JYxkCpriB7jwrQfeUMD5EvdZgNUG3zd3DovUWT~znlmza7yS6XWMSjp33UQ-eFwTOnOvhWn3pLSvyMKECS~7qQOw25klmWlL8OzAP027Yow__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37564422"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37564422/2018_JDI_Stem_cell_therapy_as_a_novel_therapeutic_intervention_for_alopecia_pdf"><img alt="Research paper thumbnail of 2018-JDI-Stem cell therapy as a novel therapeutic intervention for alopecia.pdf" class="work-thumbnail" src="https://attachments.academia-assets.com/57540719/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37564422/2018_JDI_Stem_cell_therapy_as_a_novel_therapeutic_intervention_for_alopecia_pdf">2018-JDI-Stem cell therapy as a novel therapeutic intervention for alopecia.pdf</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Management of alopecia areata (AA) and androgenetic alopecia (AGA) is often challengi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Management of alopecia areata (AA) and androgenetic alopecia (AGA) is often challenging as patients may be resistant to currently available modalities of treatment. The use of stem cells may be a novel option for resistant cases. Objective: To evaluate the safety and efficacy of the use of autologous bone marrow derived mono-nuclear cells (including stem cells) as compared to follicular stems cells for the management of resistant cases of AA and AGA. Methods: This study included 40 patients (20 AA patients and 20 AGA patients), all patients were treated with a single session of intradermal injection of autologous stem cells (SCs) therapy. They were divided into four groups according to the applied modality [either autologous bone marrow derived mononuclear cells (bone marrow mononuclear cells [BMMCs] or autologous follicular stem cells [FSC]). Results: Six months after stem cell therapy (SCT) injection, there was a significant improvement, confirmed by immunostaining and digital dermoscopy. The mean improvement in all groups was " very good ". There was no significant difference between both methods in either type of alopecia. No serious adverse events were reported. Conclusion: Autologous BMMCs and FSC seem to be a safe tolerable and effective treatment for the management of both resistant AA and AGA.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="34c6a7b42358c5f08900dbca324b07d7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57540719,"asset_id":37564422,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57540719/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37564422"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37564422"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37564422; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37559333"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37559333/2018_OncologyLetter_A_novel_strategy_for_enhancing_the_antitumor_immunity_in_breast_cancer_patients_pdf"><img alt="Research paper thumbnail of 2018-OncologyLetter_A novel strategy for enhancing the antitumor immunity in breast cancer patients.pdf" class="work-thumbnail" src="https://attachments.academia-assets.com/57535989/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37559333/2018_OncologyLetter_A_novel_strategy_for_enhancing_the_antitumor_immunity_in_breast_cancer_patients_pdf">2018-OncologyLetter_A novel strategy for enhancing the antitumor immunity in breast cancer patients.pdf</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dendritic cells (DCs) have been used in a number of clinical trials for cancer immunotherapy; how...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dendritic cells (DCs) have been used in a number of clinical trials for cancer immunotherapy; however, they have achieved limited success in solid tumors. Consequently the aim of the present study was to identify a novel potential immunotherapeutic target for breast cancer patients through in vitro optimization of a viable DC-based vaccine. Immature DCs were primed by viable MCF-7 breast cancer cells and the activity and maturation of DCs were assessed through measuring CD83, CD86 and major histocompatibility complex (MHC)-II expression, in addition to different T cell subpopu-lations, namely CD4 + T cells, CD8 + T cells, and CD4 + CD25 + forkhead box protein 3 (Foxp3) + regulatory T cells (Tregs), by flow cytometric analysis. Foxp3 level was also measured by enzyme-linked immunosorbent assay (ELISA) in addition to reverse-transcription quantitative polymerase chain reaction. The levels of interleukin-12 (IL-12) and interferon-γ (IFN-γ) were determined by ELISA. Finally, the cytotoxicity of cytotoxic T lymphocytes (CTLs) was evaluated through measuring lactate dehydrogenase (LDH) release by ELISA. The results demonstrated that CD83 + , CD86 + and MHC-II + DCs were significantly elevated (P<0.001) following priming with breast cancer cells. In addition, there was increased activation of CD4 + and CD8 + T‑cells, with a significant decrease of CD4 + CD25 + Foxp3 + Tregs (P<0.001). Furthermore, a significant downregulation of FOXP3 gene expression (P<0.001) was identified, and a significant decrease in the level of its protein following activation (P<0.001) was demonstrated by ELISA. Additionally, significant increases in the secretion of IL‑12 and IFN-γ (P= 0.001) were observed. LDH release was significantly increased (P<0.001), indicating a marked cytotoxicity of CTLs against cancer cells. Therefore viable breast cancer cell-DC-based vaccines could expose an innovative avenue for a novel breast cancer immunotherapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3e8b37c643cd6c32a459e2ff5978ef8c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57535989,"asset_id":37559333,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57535989/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37559333"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37559333"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37559333; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37559240"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37559240/_%D8%A7%D9%84%D8%B3%D9%8A%D8%B1%D8%A9_%D8%A7%D9%84%D8%B0%D8%A7%D8%AA%D9%8A%D8%A9_%D9%84%D9%84%D8%B3%D9%8A%D8%AF_%D9%84%D9%84%D8%A3%D8%B3%D8%AA%D8%A7%D8%B0_%D8%A7%D9%84%D8%AF%D9%83%D8%AA%D9%88%D8%B1_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7_%D9%85%D8%B5%D8%B1"><img alt="Research paper thumbnail of ‫‫السيرة‬ الذاتية للسيد ‫للأستاذ ‫الدكتور‬ ‫محمد لبيب سالم - جامعة طنطا - مصر" class="work-thumbnail" src="https://attachments.academia-assets.com/57535972/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37559240/_%D8%A7%D9%84%D8%B3%D9%8A%D8%B1%D8%A9_%D8%A7%D9%84%D8%B0%D8%A7%D8%AA%D9%8A%D8%A9_%D9%84%D9%84%D8%B3%D9%8A%D8%AF_%D9%84%D9%84%D8%A3%D8%B3%D8%AA%D8%A7%D8%B0_%D8%A7%D9%84%D8%AF%D9%83%D8%AA%D9%88%D8%B1_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7_%D9%85%D8%B5%D8%B1">‫‫السيرة‬ الذاتية للسيد ‫للأستاذ ‫الدكتور‬ ‫محمد لبيب سالم - جامعة طنطا - مصر</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1a36dc082db2fb299bac8de03fd4ca61" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":57535972,"asset_id":37559240,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/57535972/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37559240"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37559240"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37559240; 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} }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165099"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123165099/Mycosis_fungoides_Review_and_updates"><img alt="Research paper thumbnail of Mycosis fungoides: Review and updates" class="work-thumbnail" src="https://attachments.academia-assets.com/117664207/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123165099/Mycosis_fungoides_Review_and_updates">Mycosis fungoides: Review and updates</a></div><div class="wp-workCard_item"><span>International journal of dermatology, venereology and leprosy sciences</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mycosis fungoides is the most common type of cutaneous T cell lymphoma. The early diagnosis of MF...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mycosis fungoides is the most common type of cutaneous T cell lymphoma. The early diagnosis of MF is still an area of debate and challenging issue due to its resemblance to chronic inflammatory dermatoses. Therefore, MF diagnosis is usually based on clinical-pathological correlation. Different lines of treatment are available for MF according to the disease staging.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="54df0a643f976ecfa2bae93392e593bc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117664207,"asset_id":123165099,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117664207/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165099"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165099"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165099; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165095"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123165095/Lactobacillus_acidophilus_and_bifidobacterium_bifidum_reduce_chronic_HCV_progression_Thesis_Abstract"><img alt="Research paper thumbnail of Lactobacillus acidophilus and bifidobacterium bifidum reduce chronic HCV progression: Thesis Abstract" class="work-thumbnail" src="https://attachments.academia-assets.com/117664202/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123165095/Lactobacillus_acidophilus_and_bifidobacterium_bifidum_reduce_chronic_HCV_progression_Thesis_Abstract">Lactobacillus acidophilus and bifidobacterium bifidum reduce chronic HCV progression: Thesis Abstract</a></div><div class="wp-workCard_item"><span>International Journal of Cancer and Biomedical Research (Print)</span><span>, Apr 17, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Hepatitis C virus (HCV) is a major leading cause of pathogenesis of liver disease whi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Hepatitis C virus (HCV) is a major leading cause of pathogenesis of liver disease which was treated with IFN-based therapy and recently with Sovaldi®. There is a challenge to explore new drugs. Probiotics are the most common natural therapeutic that can ameliorate liver dysfunction. Aim: study the antiviral and antibacterial responses of the probiotics in patients with chronic (HCV). Materials and Methods: patients were treated with IFN/ribavirin, or both IFN and probiotics capsule that was containing L. acidophilus and Bifidobacterium spp. and administered as one capsule per day for a month. Blood and urine samples were collected before and after treatment strategies and were processed for quantitative determination of HCV PCR assay, identification of bacteria by VITEK2 system and 16S r RNA gene sequencing, estimation of probiotics antibacterial activity, as well as counts of leukocytes and CD3+ T cells and CD56+ natural killer cells. Results: Treatment of patients with L. acidophilus and Bifidobacteria spp. enhanced the responses of the patients to IFN-α and ribavirin treatment, as shown by the viral titter of HCV PCR assay that clarified the antiviral activity and also the antibacterial activity against the most common bacterial infections in patients with chronic HCV. Additionally, it increased the numbers of CD3+ and CD56+, Conclusions: Treatment with probiotics before IFN-α and ribavirin therapy can act as a supportive supplement with antiviral, positive immune response and antibacterial activities.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b5111bc09c6b535dbf7b310933936692" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117664202,"asset_id":123165095,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117664202/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165095"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165095"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165095; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123165095]").text(description); $(".js-view-count[data-work-id=123165095]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123165095; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123165095']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b5111bc09c6b535dbf7b310933936692" } } $('.js-work-strip[data-work-id=123165095]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123165095,"title":"Lactobacillus acidophilus and bifidobacterium bifidum reduce chronic HCV progression: Thesis Abstract","internal_url":"https://www.academia.edu/123165095/Lactobacillus_acidophilus_and_bifidobacterium_bifidum_reduce_chronic_HCV_progression_Thesis_Abstract","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":117664202,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117664202/thumbnails/1.jpg","file_name":"article_164785_14d26ee010916ba2810db196585c9724.pdf","download_url":"https://www.academia.edu/attachments/117664202/download_file","bulk_download_file_name":"Lactobacillus_acidophilus_and_bifidobact.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117664202/article_164785_14d26ee010916ba2810db196585c9724-libre.pdf?1724462136=\u0026response-content-disposition=attachment%3B+filename%3DLactobacillus_acidophilus_and_bifidobact.pdf\u0026Expires=1739931653\u0026Signature=O-t1JSOrz3m7KkSt3VljK4m8N2mjljpQM8bzRnA4dZaqFSkPItgIVSCgEqZlia9kXLxpFFygYLM7gZaF9lILe8KfB1m4NF-wE~pYZWRjOGSjYNuXIN9LS7PMDVDJW5Q1kqHRUC7EZhDnkj--CFH8j9YVK5mZQQkV4AlZgP-FKc2FgkOjRgsrqPSKUTKhpQ7WNZrux0zlUqoxCOuOo1dTnAuFTd9TkUzY8AcijCrgzzPdG6XZ9n9bqZ0H~EhHfP9UzDMvKZwgXjob8zQFCjg046p9mPdrfzpRg5C7EZ1YarAdsQT53Diexz-j3vUG5OJQEf~PI5XhCt7whLGvCXtDuA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165094"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123165094/Comparative_histological_and_immunological_studies_on_young_and_aged_inbred_and_outbred_mice_PhD_Thesis_Abstract"><img alt="Research paper thumbnail of Comparative histological and immunological studies on young and aged inbred and outbred mice: PhD Thesis Abstract" class="work-thumbnail" src="https://attachments.academia-assets.com/117664201/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123165094/Comparative_histological_and_immunological_studies_on_young_and_aged_inbred_and_outbred_mice_PhD_Thesis_Abstract">Comparative histological and immunological studies on young and aged inbred and outbred mice: PhD Thesis Abstract</a></div><div class="wp-workCard_item"><span>International Journal of Cancer and Biomedical Research (Print)</span><span>, Apr 17, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Using of experimental animal as models to mimic human pathological conditions has fac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Using of experimental animal as models to mimic human pathological conditions has facilitated understanding the mechanisms of different processes involved in these diseases. Among the experimental animals, mice are the mostly widely used animals in different experimental biology since it has a small size, easy breading, low cost, high fertility rate, and the extensive knowledge of its genome. The differences in the immune cell complements between young and adult mice, however, have not been well investigated. Aim: The present study aimed to compare aging on the immune cell components in outbreed and inbreed mice as well as to evaluate the their responses to the inflammatory stimuli Polyinosinic:polycytidylic acid (poly(I:C)). Results: The study investigated whether the aging or the poly(I:C) has the more damaging effect on the cell histology of the thymus gland and spleen. This study confirms that the alteration in the histology of the spleen of aged mice as compared to young mice. Furthermore, poly(I:C) had more tendency to induce alteration in the architecture and cellular components in the thymus and spleen of old mice than those in young mice. Conclusion: Immune compartments in old mice are more susceptible to inflammation than those in young mice.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="28444bbab1658ce508c9b9e9afbac7d2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117664201,"asset_id":123165094,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117664201/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165094"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165094"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165094; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123165094]").text(description); $(".js-view-count[data-work-id=123165094]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123165094; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123165094']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "28444bbab1658ce508c9b9e9afbac7d2" } } $('.js-work-strip[data-work-id=123165094]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123165094,"title":"Comparative histological and immunological studies on young and aged inbred and outbred mice: PhD Thesis Abstract","internal_url":"https://www.academia.edu/123165094/Comparative_histological_and_immunological_studies_on_young_and_aged_inbred_and_outbred_mice_PhD_Thesis_Abstract","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":117664201,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117664201/thumbnails/1.jpg","file_name":"article_164780_a060e0c63446195a5a6e7d98314b10c6.pdf","download_url":"https://www.academia.edu/attachments/117664201/download_file","bulk_download_file_name":"Comparative_histological_and_immunologic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117664201/article_164780_a060e0c63446195a5a6e7d98314b10c6-libre.pdf?1724462138=\u0026response-content-disposition=attachment%3B+filename%3DComparative_histological_and_immunologic.pdf\u0026Expires=1739931653\u0026Signature=BKmep6W2YUhySGwWLv3tBfYsa8FpQthoJ8X3Ss6gWrO7L57SEgjMpJC8w2xJD5O9XhoOUFGsOLugjhVljOsAmaGsSkd-OMZ-0lMnUbNiPDAcFOqWxbIScdujxY8BM2KvsfeXtRoHvCMZjdP1R0MdjIVkjLFba5zrFjP1O6SivrSb7jG-9zqqPSmUVFRUPBg3F437far8584hAoKdjXpRVvQLVo6ZJ9mwaVEe-GsJY6UY6n-1o-J6I4PcqNSpCIL2aQePyxceabvOfHi-k2kv-sgN0eBIJagus2WUVmblFQXdGVvv~jW-JP2MiIojwx2h2EHQCymOD3y8-FUh5BcVGQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165093"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123165093/High_expression_of_the_checkpoint_molecule_PD_1_on_regulatory_and_helper_CD4_T_cells_in_metastatic_breast_cancer_patients_with_poor_prognosis"><img alt="Research paper thumbnail of High expression of the checkpoint molecule PD-1 on regulatory and helper CD4+ T cells in metastatic breast cancer patients with poor prognosis" class="work-thumbnail" src="https://attachments.academia-assets.com/117664200/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123165093/High_expression_of_the_checkpoint_molecule_PD_1_on_regulatory_and_helper_CD4_T_cells_in_metastatic_breast_cancer_patients_with_poor_prognosis">High expression of the checkpoint molecule PD-1 on regulatory and helper CD4+ T cells in metastatic breast cancer patients with poor prognosis</a></div><div class="wp-workCard_item"><span>International Journal of Cancer and Biomedical Research (Print)</span><span>, Jun 2, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Recurrence and metastasis are common in patients of breast cancer even after chemothe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Recurrence and metastasis are common in patients of breast cancer even after chemotherapy and radiotherapy. This recurrence may occur due to the emergence of immunoregulatory T (Treg) cells and the immune checkpoint molecules such as programmed cell death protein 1 (PD-1) which are known to suppress anti-tumor immunity. Aim: The aim of this study is to investigate the numbers of Treg cells and the expression of PD-1 molecule on T cells in the peripheral blood of breast cancer patients at different stages (II, III, and IV) compared to healthy individuals. Materials and Methods: Blood samples were collected from early diagnosed metastatic breast cancer patients before surgery. Leucocytes were stained with different antibodies including CD4, CD25, CD127, and PD1, and then were analyzed by multiparametric flow cytometry. Results: The results showed that the relative and absolute numbers of Treg cells were significantly increased in breast cancer patients. Interestingly, we found a correlation between the numbers and cancer progression from stages II to III and IV, as compared with healthy individuals. Furthermore, significant increases in PD-1 expression were observed on Treg cells and CD4 + T cells in cancer patients as compared to healthy controls. This profile of PD-1 expression was also correlated with the poor prognosis of the patients. Conclusion: The results provide a better understanding of the immunomodulatory role of Treg cells and PD-1 expression in breast cancer patients who are the target for immunotherapy using checkpoint inhibitors.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e3a08d59f4bb983f4627e5567aba679d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117664200,"asset_id":123165093,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117664200/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165093"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165093"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165093; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165092"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123165092/Superparamagnetic_graphene_oxide_magnetite_nanocomposite_delivery_system_for_doxorubicin_induced_distinguished_tumor_cell_cycle_arrest_and_apoptosis"><img alt="Research paper thumbnail of Superparamagnetic graphene oxide/magnetite nanocomposite delivery system for doxorubicin-induced distinguished tumor cell cycle arrest and apoptosis" class="work-thumbnail" src="https://attachments.academia-assets.com/117664226/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123165092/Superparamagnetic_graphene_oxide_magnetite_nanocomposite_delivery_system_for_doxorubicin_induced_distinguished_tumor_cell_cycle_arrest_and_apoptosis">Superparamagnetic graphene oxide/magnetite nanocomposite delivery system for doxorubicin-induced distinguished tumor cell cycle arrest and apoptosis</a></div><div class="wp-workCard_item"><span>Journal of Nanoparticle Research</span><span>, Jul 22, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Super paramagnetic graphene oxide (GO)-Fe3O4 nanoparticle composites were prepared and characteri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Super paramagnetic graphene oxide (GO)-Fe3O4 nanoparticle composites were prepared and characterized by conventional techniques such as XRD, SEM, EDX, FT-IR, Raman, XPS, DLS and zeta potential, etc. TEM studies have confirmed nanoparticle nature of the composites. The magnetic nanoparticle composites can be dispersed in mildly acidic aqueous solutions and get concentrated in a small volume under application of an external magnetic field. The composites were evaluated for the uptake of actinide ions such as Am 3+ , UO2 2+ , Th 4+ and Pu 4+ from mildly aqueous acidic solutions. Am 3+ sorption sharply increased with pH as the Kd values increased from about 10 at pH 1 to 10 5 at pH 3 beyond which a much less steeper decrease in the Kd values was seen. Eu 3+ displayed nearly comparable uptake behaviour to that of Am 3+ while the uptake of other metal ions followed the trend: Pu(IV) > Th(IV) >> UO2 2+. The adsorption behaviour of Am 3+ onto the graphene oxide-Fe3O4 nanoparticle composites fitted very well to the Langmuir as well as Temkin isotherm models. The desorption rate (using 1 M HNO3) was fast and reusability study results were highly encouraging. The very high uptake values suggest possible application of the magnetic nanoparticles in radioactive waste remediation in natural ground water.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="990bd87288c083b4012a55417b70084b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117664226,"asset_id":123165092,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117664226/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165092"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165092"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165092; 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123165090]").text(description); $(".js-view-count[data-work-id=123165090]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123165090; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123165090']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=123165090]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123165090,"title":"IL-12 conditioning of peripheral blood mononuclear cells from breast cancer patients promotes the zoledronate-induced expansion of γδ T cells in vitro and enhances their cytotoxic activity and cytokine production","internal_url":"https://www.academia.edu/123165090/IL_12_conditioning_of_peripheral_blood_mononuclear_cells_from_breast_cancer_patients_promotes_the_zoledronate_induced_expansion_of_%CE%B3%CE%B4_T_cells_in_vitro_and_enhances_their_cytotoxic_activity_and_cytokine_production","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165089"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/123165089/A_feasibility_and_safety_study_of_vaccination_with_Poly_ICLC_and_peptide_pulsed_dendritic_cells_in_patients_with_advanced_pancreatic_adenocarcinoma"><img alt="Research paper thumbnail of A feasibility and safety study of vaccination with Poly-ICLC and peptide-pulsed dendritic cells in patients with advanced pancreatic adenocarcinoma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/123165089/A_feasibility_and_safety_study_of_vaccination_with_Poly_ICLC_and_peptide_pulsed_dendritic_cells_in_patients_with_advanced_pancreatic_adenocarcinoma">A feasibility and safety study of vaccination with Poly-ICLC and peptide-pulsed dendritic cells in patients with advanced pancreatic adenocarcinoma</a></div><div class="wp-workCard_item"><span>Journal of Clinical Oncology</span><span>, May 20, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">e14579Background: Dendritic cells (DCs) shape the quantity and quality of anti-tumor immunity in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">e14579Background: Dendritic cells (DCs) shape the quantity and quality of anti-tumor immunity in patients with cancer. We hypothesized that DC-based immunotherapy, in conjunction with a novel long-...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165089"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165089"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165089; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123165089]").text(description); $(".js-view-count[data-work-id=123165089]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123165089; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123165089']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=123165089]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123165089,"title":"A feasibility and safety study of vaccination with Poly-ICLC and peptide-pulsed dendritic cells in patients with advanced pancreatic adenocarcinoma","internal_url":"https://www.academia.edu/123165089/A_feasibility_and_safety_study_of_vaccination_with_Poly_ICLC_and_peptide_pulsed_dendritic_cells_in_patients_with_advanced_pancreatic_adenocarcinoma","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165088"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123165088/Anti_fibrotic_potential_of_human_umbilical_cord_mononuclear_cells_and_mouse_bone_marrow_cells_in_CCl4_induced_liver_fibrosis_in_mice"><img alt="Research paper thumbnail of Anti-fibrotic potential of human umbilical cord mononuclear cells and mouse bone marrow cells in CCl4- induced liver fibrosis in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/117664232/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123165088/Anti_fibrotic_potential_of_human_umbilical_cord_mononuclear_cells_and_mouse_bone_marrow_cells_in_CCl4_induced_liver_fibrosis_in_mice">Anti-fibrotic potential of human umbilical cord mononuclear cells and mouse bone marrow cells in CCl4- induced liver fibrosis in mice</a></div><div class="wp-workCard_item"><span>Biomedicine & Pharmacotherapy</span><span>, May 1, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Liver fibrosis is the consequence of hepatocyte injury that leads to the activation of hepatic st...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Liver fibrosis is the consequence of hepatocyte injury that leads to the activation of hepatic stellate cells (HSC). The treatment of choice is Liver transplantation; however, it has many problems such as surgeryrelated complications, immunological rejection and high costs associated with the procedure. Stem cellbased therapy would be a potential alternative, so the aim of this study is to investigate the therapeutic potential of human umbilical cord mononuclear cells (MNC) and mouse bone marrow cells (BMC) against carbon tetrachloride (CCl 4 ) induced liver fibrosis in mice and compare it with that of silymarin. In the present study, male albino mice (N = 60) were divided into six groups (10 mice each), the first group served as the normal control group while the remaining five groups were rendered fibrotic by intraperitoneal injections of CCl 4 and being left for 6 weeks to develop hepatic fibrosis. Thereafter, the mice were divided into CCl 4 group, CCl 4 group receiving MNC or BMC or silymarin or MNC and silymarin combination. After the specified treatment period, animals were then euthanized, blood and tissue samples were collected for measurement of alanine aminotransferase(ALT), aspartate aminotransferase (AST), malondialdehyde(MDA), reduced glutathione(GSH), collagen, Laminin, transforming growth factor b1(TGFb1), tumor necrosis factor alpha(TNFa). MNC, BMC, and the combination therapy showed a significant decrease in ALT, AST, MDA, collagen, Laminin, TGFb1, and TNFa and a significant increase in GSH. The data displayed a similar regression of fibrosis with the histological and immunohistological parameters. In conclusion, MNC, BMC and the combination therapy showed a potential therapeutic effect against liver fibrosis via reducing oxidative stress, inflammatory mediators, and fibrogenic markers.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="01163066f8dc7785cc260af9e40135fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117664232,"asset_id":123165088,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117664232/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165088"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165088"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165088; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123165088]").text(description); $(".js-view-count[data-work-id=123165088]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123165088; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123165088']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "01163066f8dc7785cc260af9e40135fe" } } $('.js-work-strip[data-work-id=123165088]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123165088,"title":"Anti-fibrotic potential of human umbilical cord mononuclear cells and mouse bone marrow cells in CCl4- induced liver fibrosis in mice","internal_url":"https://www.academia.edu/123165088/Anti_fibrotic_potential_of_human_umbilical_cord_mononuclear_cells_and_mouse_bone_marrow_cells_in_CCl4_induced_liver_fibrosis_in_mice","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":117664232,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117664232/thumbnails/1.jpg","file_name":"j.biopha.2017.03.00720240824-1-cd1ca1.pdf","download_url":"https://www.academia.edu/attachments/117664232/download_file","bulk_download_file_name":"Anti_fibrotic_potential_of_human_umbilic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117664232/j.biopha.2017.03.00720240824-1-cd1ca1-libre.pdf?1724462148=\u0026response-content-disposition=attachment%3B+filename%3DAnti_fibrotic_potential_of_human_umbilic.pdf\u0026Expires=1739893515\u0026Signature=aV87Jw5vyXIJtemczVdK09ylSv6a5lxsolLjWwiUS31wI3uVwi0TNloHiOl6ctImYKvJQAJZWtJMg89JRpZTK3ClUtSwsQfuTOmQj~O46RODoJf0bE6SFdJ5NW8L3vZdtqA0Tx7pt1DugPUKg1DqV1EmZ2y3blPNi6usryTGwyxLtG7cCFzvpM8MoCUsAMPJWCSKpzx-enSDzO2yw4IJcAZHgGC2sUZIj2dPJqtBom8Uc8MflVHnbYBZblBUDXvpSCIDXUyCZISVYPZ1njjZ7IFQjwc0t7h-MvPnJzLzIX7EdctdeQBV-9btcVWvlQ0gzTaICp4TAf22G6rqS5czhg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165087"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/123165087/Recent_Research_on_Flavonoids_and_their_Biomedical_Applications"><img alt="Research paper thumbnail of Recent Research on Flavonoids and their Biomedical Applications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/123165087/Recent_Research_on_Flavonoids_and_their_Biomedical_Applications">Recent Research on Flavonoids and their Biomedical Applications</a></div><div class="wp-workCard_item"><span>Current Medicinal Chemistry</span><span>, Feb 1, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Flavonoids, commonly found in various plants, are a class of polyphenolic compounds having a basi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Flavonoids, commonly found in various plants, are a class of polyphenolic compounds having a basic structural unit of 2-phenylchromone. Flavonoid compounds have attracted much attention due to their wide biological applications. In order to facilitate further research on the biomedical application of flavonoids, we surveyed the literature published on the use of flavonoids in medicine during the past decade, documented the commonly found structures in natural flavonoids, and summarized their pharmacological activities as well as associated mechanisms of action against a variety of health disorders including chronic inflammation, cancer, cardiovascular complications and hypoglycemia. In this mini-review, we provide suggestions for further research on the biomedical applications of flavonoids.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165087"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165087"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165087; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123165087]").text(description); $(".js-view-count[data-work-id=123165087]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123165087; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123165087']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=123165087]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123165087,"title":"Recent Research on Flavonoids and their Biomedical Applications","internal_url":"https://www.academia.edu/123165087/Recent_Research_on_Flavonoids_and_their_Biomedical_Applications","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165086"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123165086/Routine_childhood_immunization_may_protect_against_COVID_19"><img alt="Research paper thumbnail of Routine childhood immunization may protect against COVID-19" class="work-thumbnail" src="https://attachments.academia-assets.com/117664225/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123165086/Routine_childhood_immunization_may_protect_against_COVID_19">Routine childhood immunization may protect against COVID-19</a></div><div class="wp-workCard_item"><span>Medical Hypotheses</span><span>, Jul 1, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="96251afb749074584bd741b6e8a02d54" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117664225,"asset_id":123165086,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117664225/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165086"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165086"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165086; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123165086]").text(description); $(".js-view-count[data-work-id=123165086]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123165086; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123165086']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "96251afb749074584bd741b6e8a02d54" } } $('.js-work-strip[data-work-id=123165086]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123165086,"title":"Routine childhood immunization may protect against COVID-19","internal_url":"https://www.academia.edu/123165086/Routine_childhood_immunization_may_protect_against_COVID_19","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":117664225,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117664225/thumbnails/1.jpg","file_name":"pmc7270579.pdf","download_url":"https://www.academia.edu/attachments/117664225/download_file","bulk_download_file_name":"Routine_childhood_immunization_may_prote.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117664225/pmc7270579-libre.pdf?1724462135=\u0026response-content-disposition=attachment%3B+filename%3DRoutine_childhood_immunization_may_prote.pdf\u0026Expires=1739931653\u0026Signature=Jl4Yw4eS3qbL0cHRCDGAtLTlHldu9NhFMiP8Axz4Myd~qa47JPlck6CfwKb-0Dcqkyvs47lMy7lCQfWTnFayU6134FzuSawtncrbG8pspi~48CBz21nuOPdidpC-6mu47Ms1ZnnjFGMoHVKkRh050DCA8U05Tr2lYR9GRFUvjxNzcaYRbea2K7~GN7VkdRW-aDq5mPvm4s6G~4WAaIYHqIm3YJwNpOxRfG~pJR4B7BAJn79m-Ut-YWLVu57JZ930qTMQVT4yZaDpJoWkI-2ZPJMkPAUXEfbOiXra2-Xsc8tFcHPwOLIUUWE51N2b9gj4my-SdTUQSRsopzYVcNWXzQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165085"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123165085/Protective_effect_of_black_seed_oil_from_Nigella_sativa_against_murine_cytomegalovirus_infection"><img alt="Research paper thumbnail of Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection" class="work-thumbnail" src="https://attachments.academia-assets.com/117664233/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123165085/Protective_effect_of_black_seed_oil_from_Nigella_sativa_against_murine_cytomegalovirus_infection">Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection</a></div><div class="wp-workCard_item"><span>International Journal of Immunopharmacology</span><span>, Sep 1, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this study, antiviral eect of black seed oil (BSO) from Nigella sativa was investigated using ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this study, antiviral eect of black seed oil (BSO) from Nigella sativa was investigated using murine cytomegalovirus (MCMV) as a model. The viral load and innate immunity mediated by NK cells and Mf during early stage of the infection were analyzed. Intraperitoneal (i.p.) administration of BSO to BALB/c mice, a susceptible strain of MCMV infection, strikingly inhibited the virus titers in spleen and liver on day 3 of infection with 1 Â 10 5 PFU MCMV. This eect coincided with an increase in serum level of IFN-g. Although BSO treatment decreased both number and cytolytic function of NK cells on day 3 of infection, it increased numbers of Mf and CD4 + T cells. On day 10 of infection, the virus titer was undetectable in spleen and liver of BSO-treated mice, while it was detectable in control mice. Although spleen of both control and BSO-treated mice showed similar CTL activities on day 10 after infection, serum level of IFN-g in BSO-treated mice was higher. Furthermore, BSO treatment upregulated suppressor function of Mf in spleen. These results show that BSO exhibited a striking antiviral eect against MCMV infection which may be mediated by increasing of Mf number and function, and IFN-g production.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0ab0f965c8001be63af4d632dbd38fec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117664233,"asset_id":123165085,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117664233/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165085"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165085"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165085; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123165085]").text(description); $(".js-view-count[data-work-id=123165085]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123165085; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123165085']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0ab0f965c8001be63af4d632dbd38fec" } } $('.js-work-strip[data-work-id=123165085]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123165085,"title":"Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection","internal_url":"https://www.academia.edu/123165085/Protective_effect_of_black_seed_oil_from_Nigella_sativa_against_murine_cytomegalovirus_infection","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":117664233,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117664233/thumbnails/1.jpg","file_name":"s0192-056128002900036-920240824-1-rbovbl.pdf","download_url":"https://www.academia.edu/attachments/117664233/download_file","bulk_download_file_name":"Protective_effect_of_black_seed_oil_from.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117664233/s0192-056128002900036-920240824-1-rbovbl-libre.pdf?1724462139=\u0026response-content-disposition=attachment%3B+filename%3DProtective_effect_of_black_seed_oil_from.pdf\u0026Expires=1739931653\u0026Signature=ZZKBbcrhTZO5COuBhoffOZ0KfpIB1jxiRz~7k-MFrhW9LAEK~FdaQjGuV2~SSDhvUvX-EFfV8vn~3kgbdH~4AgepxJK8klrbmtTfVaBS5au5tZgPmPTUP58eK0gGPBXXWvBG0eMOngrxhxZRpb1z2SqjBYCiZmcZf4hdQHiM4TecgIfP79UB2oc03YPJDPuuFm70liw48hscT-4OpztgqH79DCHyF49kN1FwAE8DdTRSsweUP6Ulq9IDhVC5fUGqvo94R1Pi5TwZ5BenJM4HN0g5XBKW9qgw5NpBqX9areDXLS-10Jr6Qyz1tqlNi1WpKhjTBxWq8xwCZe1yHYBJAQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165084"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/123165084/The_TLR3_agonist_poly_I_C_acted_directly_on_mouse_CD8_T_cells_and_augmented_their_antigen_specific_responses_upon_adoptive_transfer_into_nai_ve_recipient_mice_48_31_"><img alt="Research paper thumbnail of The TLR3 agonist poly (I:C) acted directly on mouse CD8 T cells and augmented their antigen-specific responses upon adoptive transfer into naïve recipient mice (48.31)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/123165084/The_TLR3_agonist_poly_I_C_acted_directly_on_mouse_CD8_T_cells_and_augmented_their_antigen_specific_responses_upon_adoptive_transfer_into_nai_ve_recipient_mice_48_31_">The TLR3 agonist poly (I:C) acted directly on mouse CD8 T cells and augmented their antigen-specific responses upon adoptive transfer into naïve recipient mice (48.31)</a></div><div class="wp-workCard_item"><span>Journal of Immunology</span><span>, Apr 1, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have reported that in vivo administration of the toll-like receptor 3 ligand (TLRL) poly (I:C)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have reported that in vivo administration of the toll-like receptor 3 ligand (TLRL) poly (I:C) induced rapid stimulation of the innate mediators, including NK cells, Mϕ, dendritic cells, and inflammatory cytokines. These effects strikingly augmented post vaccination CD8 T cells responses. It is not clear, however, whether poly (I:C) acts directly on CD8 T cells. Therefore, we analyzed the expression of TLRs on both CD4 and CD8 T cells and tested whether CD8 T cells respond directly to poly (I:C). Real-time PCR analysis revealed that TLRs (TLR1-TLR13) are expressed in the purified CD4 and CD8 T cells, and their in vitro treatment with 50 μg/ml poly 10 nM PMA, or with OVA peptide-pulsed splenocytes modulated the expression of the tested TLRs. Utilizing OT-1 TCR adoptive transfer transgenic mouse model, in vitro treatment of purified naïve OT-1 cells with 50 μg/ml poly (I:C) for 18 hours in the absence of antigen stimulation triggered their activation as evidenced by upregulation of the early activation markers CD69 and CD25, and downregulation of CD62L expression. Importantly, when these cells were adoptively transferred into naïve recipient followed by peptide vaccination, they showed superior expansion and activation to their naïve counterparts. These results clearly reveal a direct effect of poly (I:C) on CD8 T cells and supports the notion of direct involvement of TLRs in adaptive immune responses.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165084"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165084"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165084; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123165084]").text(description); $(".js-view-count[data-work-id=123165084]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123165084; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123165084']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=123165084]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123165084,"title":"The TLR3 agonist poly (I:C) acted directly on mouse CD8 T cells and augmented their antigen-specific responses upon adoptive transfer into naïve recipient mice (48.31)","internal_url":"https://www.academia.edu/123165084/The_TLR3_agonist_poly_I_C_acted_directly_on_mouse_CD8_T_cells_and_augmented_their_antigen_specific_responses_upon_adoptive_transfer_into_nai_ve_recipient_mice_48_31_","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="123165083"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/123165083/_i_Ex_vivo_i_activity_of_i_early_i_cytokine_conditioned_effector_CD8_T_cells_inversely_correlates_with_their_anti_tumor_activity_i_in_vivo_i_41_1_"><img alt="Research paper thumbnail of <i>Ex vivo</i> activity of <i>early</i> cytokine conditioned effector CD8+ T cells inversely correlates with their anti-tumor activity <i>in vivo</i> (41.1)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/123165083/_i_Ex_vivo_i_activity_of_i_early_i_cytokine_conditioned_effector_CD8_T_cells_inversely_correlates_with_their_anti_tumor_activity_i_in_vivo_i_41_1_"><i>Ex vivo</i> activity of <i>early</i> cytokine conditioned effector CD8+ T cells inversely correlates with their anti-tumor activity <i>in vivo</i> (41.1)</a></div><div class="wp-workCard_item"><span>Journal of Immunology</span><span>, Apr 1, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Enhanced effector activity such as cytokine secretion, cell proliferation , cytolytic activity, e...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Enhanced effector activity such as cytokine secretion, cell proliferation , cytolytic activity, etc. in response to in vitro stimulation has been widely used as a means to predict in vivo activity after immune mediated interventions, such as adoptive transfer or systemic vaccination. Contrary to this, here we show that the enhanced in vivo survival and anti-tumor activity of cytokine conditioned early activated CD8+ T cells inversely correlates with their effector functions in vitro. When compared with late effector PmelIL-12, early effector showed decreased production of IFNγ and TNFα, and decreased expression of the degranulation marker CD107a in response to in vitro reactivation. However, after transfer into lymphodepleted hosts, early effector PmelIL-12 survived for at least 20 days and were able to effectively control the progression of B16 tumors in a superior manner than late effector PmelIL-12. Thus, effector activity in response to ex vivo antigenic restimulation does not necessarily predict in vivo activity. Other parameters such as surface expression of functional markers (CCR7, CD62L) and /or survival (CD127) could serve as better predictors of in vivo activity. Developing and validating accurate predictors of in vivo lymphocyte function would greatly facilitate our ability to rationally design novel immune based therapies for clinical trials that have significant anti-tumor activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123165083"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123165083"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123165083; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="240397" id="teachingdocuments"><div class="js-work-strip profile--work_container" data-work-id="121275390"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121275390/%D8%A7%D9%84%D8%AD%D8%B6%D8%A7%D8%B1%D8%A7%D8%AA_%D9%88%D9%82%D8%B6%D9%8A%D8%A9_%D8%A5%D8%B9%D9%85%D8%A7%D9%84_%D8%A7%D9%84%D8%B9%D9%82%D9%84_%D8%A7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85"><img alt="Research paper thumbnail of الحضارات وقضية إعمال العقل ا.د. محمد لبيب سالم" class="work-thumbnail" src="https://attachments.academia-assets.com/116196729/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121275390/%D8%A7%D9%84%D8%AD%D8%B6%D8%A7%D8%B1%D8%A7%D8%AA_%D9%88%D9%82%D8%B6%D9%8A%D8%A9_%D8%A5%D8%B9%D9%85%D8%A7%D9%84_%D8%A7%D9%84%D8%B9%D9%82%D9%84_%D8%A7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85">الحضارات وقضية إعمال العقل ا.د. محمد لبيب سالم</a></div><div class="wp-workCard_item"><span>مقال </span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">مع أنه كان من الممكن أن ينزل الوحي علي الرسول الكريم مُحمد بدون كتاب كما حدث مع كثير من الرسل، إل...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">مع أنه كان من الممكن أن ينزل الوحي علي الرسول الكريم مُحمد بدون كتاب كما حدث مع كثير من الرسل، إلا أن الله أيده بنزول القرآن الكريم الذي تحتاج كل آية فيه إلي إعمال العقل لكي يطمئن القلب. فأول آية نزلت في غار حراء كانت عن القراءة (أعمال العقل: إقرأ) ثم العلم (إعمال العقل: خلق الإنسان من علق) ثم الكتابة (إعمال العقل: الذي علم بالقلم).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3a03b31c2751822aeb8b53025721fdba" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116196729,"asset_id":121275390,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116196729/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121275390"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121275390"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121275390; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121201339"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121201339/%D9%85%D9%88%D9%82%D9%81_%D9%81%D9%84%D8%A7%D8%B3%D9%81%D8%A9_%D8%A3%D9%88%D8%B1%D9%88%D8%A8%D8%A7_%D9%85%D9%86_%D8%A7%D9%84%D8%AD%D8%B6%D8%A7%D8%B1%D8%A9_%D8%A7%D9%84%D9%85%D8%B5%D8%B1%D9%8A%D8%A9_%D8%A7%D9%84%D9%82%D8%AF%D9%8A%D9%85%D8%A9"><img alt="Research paper thumbnail of موقف فلاسفة أوروبا من الحضارة المصرية القديمة" class="work-thumbnail" src="https://attachments.academia-assets.com/116143777/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121201339/%D9%85%D9%88%D9%82%D9%81_%D9%81%D9%84%D8%A7%D8%B3%D9%81%D8%A9_%D8%A3%D9%88%D8%B1%D9%88%D8%A8%D8%A7_%D9%85%D9%86_%D8%A7%D9%84%D8%AD%D8%B6%D8%A7%D8%B1%D8%A9_%D8%A7%D9%84%D9%85%D8%B5%D8%B1%D9%8A%D8%A9_%D8%A7%D9%84%D9%82%D8%AF%D9%8A%D9%85%D8%A9">موقف فلاسفة أوروبا من الحضارة المصرية القديمة</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">الفلسفة هي حالة من الرقي الفكري التي تعكس حضارة الشعوب المادية والمعنوية أشد ما يحزنني أثناء قرا...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">الفلسفة هي حالة من الرقي الفكري التي تعكس حضارة الشعوب المادية والمعنوية<br /><br />أشد ما يحزنني أثناء قراءتي في الفلسفة على وجه العموم وفلسفة العلم على وجه الخصوص أن معظم فلاسفة الغرب مثل هيجل يعتقدون بل ويصرحون أن الفلسفة إنتاج أوروبي مطلق تمتد جذوره في اليونان وسيقانه في أوروبا وخاصة ألمانيا (الجنس الآري الناطق باللغة الآرية) وينفون عن الحضارة المصرية القديمة التي سبقت الحضارة اليونانية بآلاف السنين والتي كانت معابدها وكهنتها (العلماء) تمثل مدارس يتعلم فيها الفلاسفة (العلماء) اليونانيين مثل "طاليس" و "فيثاغورث" وآخرهم "أرسطو". حتي أن العديد من الدراسات أثبتت أن "طاليس" نفسة أصله عربي كنعاني (فينيقي) . إنه الاستعلاء والاستقواء والغرور الذي أصاب فلاسفة أوروبا ما قبل وما بعد الحداثة (التي بدأت بعد عصر ديكارت).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="053b4dfa8ed8858d729bd70aaa9c7ebc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116143777,"asset_id":121201339,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116143777/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121201339"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121201339"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121201339; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121065025"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121065025/%D8%A7%D9%84%D8%AA%D8%B5%D9%85%D9%8A%D9%85_%D8%A7%D9%84%D8%B0%D9%83%D9%8A_%D9%88%D8%AE%D9%84%D9%82_%D8%A7%D9%84%D9%84%D9%87_%D8%A8%D9%82%D9%84%D9%85_%D8%A7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85"><img alt="Research paper thumbnail of التصميم الذكي وخلق الله بقلم ا.د. محمد لبيب سالم" class="work-thumbnail" src="https://attachments.academia-assets.com/116041946/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121065025/%D8%A7%D9%84%D8%AA%D8%B5%D9%85%D9%8A%D9%85_%D8%A7%D9%84%D8%B0%D9%83%D9%8A_%D9%88%D8%AE%D9%84%D9%82_%D8%A7%D9%84%D9%84%D9%87_%D8%A8%D9%82%D9%84%D9%85_%D8%A7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85">التصميم الذكي وخلق الله بقلم ا.د. محمد لبيب سالم</a></div><div class="wp-workCard_item"><span>2024 </span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">كل ما نفعله نحن العلماء يتراوح بين استقراء الجزيئات للوصول إلي الكليات أو استنباط الكليات للوصول ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">كل ما نفعله نحن العلماء يتراوح بين استقراء الجزيئات للوصول إلي الكليات أو استنباط الكليات للوصول إلي الجزيئات. وما هذا التفكير العلمي إلا محاولات للوصول إلي آليات خلق الله. فلم يكن هناك أحد ليشهد مراحل خلق السماوات والأرض، ولم يكن هناك أحد أثناء خلق النبات والحيوان ثم بعد ذلك الإنسان الأول ولا حتى الأخير. خلقنا ما هو إلا صندوق مغلق نحاول فك شفرته بالعلم ببطء منذ بدء الخليقة. وعندما بدأنا نفهم بعض أسرار الله في خلقه اكتشفنا أننا كالأطفال الذين لديهم سيارة أو طائرة يلعبون بها وهم لا يعرفون كيف صنعت حتى ولو كانوا يعلمون من الصانع. واذا حاولنا كيف صُنعت السيارة فعلينا فكها أولا لنتعرف علي أجزائها قطعة قطعة تم توصيلها وتركيبها مع بعضها البعض في هندسة شديدة التعقيد. ولكننا نفاجأ في النهاية أن إعادة تركيب العربة كما كانت ليس سهلا كحال تفكيكها .</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3564456f003dae238f7ab5364773181e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116041946,"asset_id":121065025,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116041946/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121065025"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121065025"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121065025; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120700820"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120700820/%D8%A7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D8%A7%D9%84%D8%B2%D9%88%D8%AC%D8%A9_%D9%88%D8%B1%D8%A7%D8%A1_%D8%A7%D9%83%D8%AA%D8%B4%D8%A7%D9%81_%D9%81%D9%8A%D8%AA%D8%A7%D9%85%D9%8A%D9%86_%D8%AC"><img alt="Research paper thumbnail of ا.د. محمد لبيب سالم الزوجة وراء اكتشاف فيتامين ج" class="work-thumbnail" src="https://attachments.academia-assets.com/115767340/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120700820/%D8%A7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D8%A7%D9%84%D8%B2%D9%88%D8%AC%D8%A9_%D9%88%D8%B1%D8%A7%D8%A1_%D8%A7%D9%83%D8%AA%D8%B4%D8%A7%D9%81_%D9%81%D9%8A%D8%AA%D8%A7%D9%85%D9%8A%D9%86_%D8%AC">ا.د. محمد لبيب سالم الزوجة وراء اكتشاف فيتامين ج</a></div><div class="wp-workCard_item"><span>الزوجة وراء اكتشاف فيتامين ج</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">الزوجة وراء اكتشاف فيتامين ج "شكرا للفلفل الأحمر" مقال بقلم د. محمد لبيب سالم من يحمي خلايانا وا...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">الزوجة وراء اكتشاف فيتامين ج<br />"شكرا للفلفل الأحمر"<br />مقال بقلم د. محمد لبيب سالم <br />من يحمي خلايانا والخلايا في الحيوانات والنباتات من العطب والشيخوخة، بل وفي النهاية الموت المبرمج. فالخلية في حالة عمل دائما ولا تنام ولا تهدأ إلى قليلا أثناء النوم. وطالما الخلية تعمل وتكد وتجتهد فلابد من تكوين مخرجات نتيجة لعملية الأكسدة التي تتسبب في إيذائها أو موتها أو تحويلها إلى خلايا سرطانية.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8407dbc73e18a72fb3e6c51d3b106ab2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115767340,"asset_id":120700820,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115767340/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120700820"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120700820"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120700820; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="101880432"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/101880432/Prof_Mohamed_Labib_Salem_CV_July_2022"><img alt="Research paper thumbnail of Prof Mohamed Labib Salem CV July 2022" class="work-thumbnail" src="https://attachments.academia-assets.com/102298224/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/101880432/Prof_Mohamed_Labib_Salem_CV_July_2022">Prof Mohamed Labib Salem CV July 2022</a></div><div class="wp-workCard_item"><span>Resume</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">He is an outstanding scholar in Immunology and Cancer Immunology based on his cutting-edge resear...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">He is an outstanding scholar in Immunology and Cancer Immunology based on his cutting-edge research in the USA, Japan, and Egypt. His main discoveries in the preclinical settings have been translated into clinic. Prof. Salem</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c61faf4d3f4dad70fbdbd00e151f174a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102298224,"asset_id":101880432,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102298224/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101880432"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101880432"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101880432; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="32720680"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/32720680/CURRICULUM_VITAE"><img alt="Research paper thumbnail of CURRICULUM VITAE" class="work-thumbnail" src="https://attachments.academia-assets.com/52880693/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/32720680/CURRICULUM_VITAE">CURRICULUM VITAE</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mohamed L. Salem (PhD, 1995) is the Professor of Immunology at Tanta University, Egypt and was Vi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mohamed L. Salem (PhD, 1995) is the Professor of Immunology at Tanta University, Egypt and was Visiting Professor at Hollings Cancer Center and Department of Microbiology and Immunology, Medical University of South Carolina, USA. Dr. Salem is the Founder and Director of Center of Excellence in Cancer Research, Tanta University, Egypt and Founder and Chairman of Egyptian Association for Cancer Research. He is among the founding members of the Middle Eastern Association for Cancer Research, Canada. Dr Salem is also the Director of Delta Development Research Center which is a regional branch of Academy of Scientific Research and Technology (ASRT), Egypt; Director of the Grant, Innovation & Technology Transfer Center. Dr. Salem obtained his PhD in 1995 through a channel system between Tanta University, Egypt and Kyushu University, Japan. From 1997 -2001, he was a Postdoctoral Fellow at Kyushu University, Japan and from 2002-2010 as an Assistant Professor at Medical University of South Carolina, USA. Dr. Salem is member of several national committees including National Committee for Professorship Promotion, National Committee for the Biological Sciences, National Committee for Scientific Research Strategies, National Committee for Basic Sciences Sector at the Supreme Council of the Egyptian Universities, and National Committee of the Special Basic Science Sector at the Academy of Scientific Research and Technology, Egypt. Dr Salem won the State Incentive Award in 2004 in Biology, the State Excellence Award in 2010 in Basic Sciences from the Academy of Scientific Research and Technology, Egypt, and Tanta University Esteemed Award, Tanta University, Egypt in 2015. His h-index is 26 and published about 111 articles in peer-reviewed journals and attended more than 100 national and international workshops and conferences in Immunology. He supervised more than 69 Master and PhD students. He is a member of several editorial boards of peer-reviewed journals as well as ad hoc reviewer for more than 80 journals. He has been invited to give scientific talks in Egypt, UAE, Jordan, Saudi Arabia, USA, China and Canada. Dr Salem’s research focuses on understanding the cellular and molecular mechanisms underlying how cancer and virus escape from host immunity, in particular the rules of the immunosuppressive cells including lymphoid and myeloid lineages as well as developing effective anticancer immunotherapy strategies. His research projects have been funded by National Institute of Health, USA, Science and Technology Development Fund (STDF), Egypt, USA National Academy of Sciences, Tanta University, Egypt, private foundation and industry.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9232e3c9e6037c6bce84ee2048f18b8b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":52880693,"asset_id":32720680,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/52880693/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="32720680"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="32720680"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 32720680; 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Researchers, however, are different than technicia...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Research requires researchers and technicians. Researchers, however, are different than technicians. Although their job description complements each other for generation of a standardized research, a researcher should be equipped with both intellectual and technical skills to deal with problem-based sciences. On the other hand, a technician needs to be equipped with technical skills, where intellectual skills are optional. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4423984"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4423984/%D8%A7%D8%B9%D9%88%D8%A7%D9%85_%D8%A7%D9%84%D8%B9%D9%85%D8%B1_%D8%A8%D9%8A%D9%86_%D8%B1%D8%AD%D9%8A%D9%84_%D9%88%D9%82%D8%AF%D9%88%D9%85"><img alt="Research paper thumbnail of اعوام العمر بين رحيل وقدوم " class="work-thumbnail" src="https://attachments.academia-assets.com/31845324/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4423984/%D8%A7%D8%B9%D9%88%D8%A7%D9%85_%D8%A7%D9%84%D8%B9%D9%85%D8%B1_%D8%A8%D9%8A%D9%86_%D8%B1%D8%AD%D9%8A%D9%84_%D9%88%D9%82%D8%AF%D9%88%D9%85">اعوام العمر بين رحيل وقدوم </a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="781d502445a4f07735d0d791e91908fb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31845324,"asset_id":4423984,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31845324/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4423984"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4423984"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4423984; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4423984]").text(description); $(".js-view-count[data-work-id=4423984]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4423984; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4423984']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4423968"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/4423968/%D9%85%D9%86%D8%A7%D8%AC%D8%A7%D8%A9_%D9%85%D9%88%D8%A7%D8%B7%D9%86"><img alt="Research paper thumbnail of مناجاة مواطن " class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/4423968/%D9%85%D9%86%D8%A7%D8%AC%D8%A7%D8%A9_%D9%85%D9%88%D8%A7%D8%B7%D9%86">مناجاة مواطن </a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4423968"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4423968"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4423968; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4423968]").text(description); $(".js-view-count[data-work-id=4423968]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4423968; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4423968']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=4423968]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4423968,"title":"مناجاة مواطن ","internal_url":"https://www.academia.edu/4423968/%D9%85%D9%86%D8%A7%D8%AC%D8%A7%D8%A9_%D9%85%D9%88%D8%A7%D8%B7%D9%86","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4423967"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4423967/%D9%83%D9%84%D9%85%D8%A7%D8%AA_%D9%85%D9%86_%D8%A7%D9%84%D9%87%D8%A7%D9%85_%D8%AD%D8%A8_%D8%A8%D9%84%D8%A7%D8%AF%D9%8A"><img alt="Research paper thumbnail of كلمات من الهام حب بلادي " class="work-thumbnail" src="https://attachments.academia-assets.com/31845317/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4423967/%D9%83%D9%84%D9%85%D8%A7%D8%AA_%D9%85%D9%86_%D8%A7%D9%84%D9%87%D8%A7%D9%85_%D8%AD%D8%A8_%D8%A8%D9%84%D8%A7%D8%AF%D9%8A">كلمات من الهام حب بلادي </a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="13b8c923a07693a6b2e40c530e692015" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31845317,"asset_id":4423967,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31845317/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4423967"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4423967"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4423967; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "13b8c923a07693a6b2e40c530e692015" } } $('.js-work-strip[data-work-id=4423967]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4423967,"title":"كلمات من الهام حب بلادي ","internal_url":"https://www.academia.edu/4423967/%D9%83%D9%84%D9%85%D8%A7%D8%AA_%D9%85%D9%86_%D8%A7%D9%84%D9%87%D8%A7%D9%85_%D8%AD%D8%A8_%D8%A8%D9%84%D8%A7%D8%AF%D9%8A","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":31845317,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/31845317/thumbnails/1.jpg","file_name":"كلمات_من_إلهام_حب_بلادي.pdf","download_url":"https://www.academia.edu/attachments/31845317/download_file","bulk_download_file_name":"31845317.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/31845317/%D9%83%D9%84%D9%85%D8%A7%D8%AA_%D9%85%D9%86_%D8%A5%D9%84%D9%87%D8%A7%D9%85_%D8%AD%D8%A8_%D8%A8%D9%84%D8%A7%D8%AF%D9%8A-libre.pdf?1391424382=\u0026response-content-disposition=attachment%3B+filename%3D31845317.pdf\u0026Expires=1739931654\u0026Signature=IYpT8wt6q6eiFlaGRj9qYNATkvexmBq~Kskn5aib3O7QyoXTu61lUOglNZwEWCH8b3INrbgix0NGRDoIrX-xXxLN2tW6lRK1pJ5pQjYYEvVq8ukm66GwriWMv9mQ~s1epRsZoFyk-9GuQiWhfPuvbjz6xwvpJ9hW~HAZAp0I~ZA2h67xnpX9343I0Vm~frECUa2MuDm5YZXv-u3l~Cv1u~14Gi-MTLNy5QgTTCO0Sk9755meIv0sVtmeOTJv0T8nOc92etJDVXTKuOZJK~gOB6n7szD6DT~ZYkO4J-83DSKVW3XzDHHDhQoJEm~kAWhuS4XmRkJtV~jYX0kb4fgYOg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4423774"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4423774/%D8%AD%D9%88%D8%A7%D8%B1_%D9%85%D8%B9_%D9%86%D9%81%D8%B3%D9%8A"><img alt="Research paper thumbnail of حوار مع نفسي " class="work-thumbnail" src="https://attachments.academia-assets.com/31845187/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4423774/%D8%AD%D9%88%D8%A7%D8%B1_%D9%85%D8%B9_%D9%86%D9%81%D8%B3%D9%8A">حوار مع نفسي </a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a92c3a70bb6f34dd35c26fcb404a8cae" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31845187,"asset_id":4423774,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31845187/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4423774"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4423774"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4423774; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4423774]").text(description); $(".js-view-count[data-work-id=4423774]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4423774; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4423774']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a92c3a70bb6f34dd35c26fcb404a8cae" } } $('.js-work-strip[data-work-id=4423774]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4423774,"title":"حوار مع نفسي ","internal_url":"https://www.academia.edu/4423774/%D8%AD%D9%88%D8%A7%D8%B1_%D9%85%D8%B9_%D9%86%D9%81%D8%B3%D9%8A","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":31845187,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/31845187/thumbnails/1.jpg","file_name":"حوار_مع_نفسي.pdf","download_url":"https://www.academia.edu/attachments/31845187/download_file","bulk_download_file_name":"31845187.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/31845187/%D8%AD%D9%88%D8%A7%D8%B1_%D9%85%D8%B9_%D9%86%D9%81%D8%B3%D9%8A-libre.pdf?1391517879=\u0026response-content-disposition=attachment%3B+filename%3D31845187.pdf\u0026Expires=1739931654\u0026Signature=IAXqzdci1WDDVgTAiNs-lPztEWValw6LqN7JigP8Rb9XaDijjfzAXjUopj164qCKuFg9jpeSp9HLcF4jXc-9MtPOi-En2lANpSLFyxoXNiAZJpQV5M6n4JYLTe0Og3UgJZWBfp5PXBhyuQbxxyD8ks4NzMFWIClPwx0XHT8TU6Pw4303hcBPd~huXIK1WFEZmrqMUb3nFyIa2GL-8BkOhvH4s1Yrrzr3DVFgoxLl3YUpacnORG0ms2FlpW4AJHM64raEBqGYwhWV77YbBv4J7NqMhWb-pBLt-JUc~WfwwFUpOcnYjfHZntw~fuW6IofihwKwKmFKOWxtU2GNLWjjvA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4423773"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4423773/%D8%AD%D8%A8_%D9%83%D8%A7%D8%B0%D8%A8"><img alt="Research paper thumbnail of حب كاذب " class="work-thumbnail" src="https://attachments.academia-assets.com/31845183/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4423773/%D8%AD%D8%A8_%D9%83%D8%A7%D8%B0%D8%A8">حب كاذب </a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f9f59bafddc02663b9710627bf305729" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31845183,"asset_id":4423773,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31845183/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4423773"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4423773"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4423773; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4423773]").text(description); $(".js-view-count[data-work-id=4423773]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4423773; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4423773']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f9f59bafddc02663b9710627bf305729" } } $('.js-work-strip[data-work-id=4423773]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4423773,"title":"حب كاذب ","internal_url":"https://www.academia.edu/4423773/%D8%AD%D8%A8_%D9%83%D8%A7%D8%B0%D8%A8","owner_id":174532,"coauthors_can_edit":true,"owner":{"id":174532,"first_name":"Prof. Mohamed","middle_initials":null,"last_name":"Labib Salem","page_name":"ProfMohamedLabibSalem","domain_name":"tanta","created_at":"2010-04-22T01:40:43.540-07:00","display_name":"Prof. Mohamed Labib Salem","url":"https://tanta.academia.edu/ProfMohamedLabibSalem"},"attachments":[{"id":31845183,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/31845183/thumbnails/1.jpg","file_name":"حب_كاذب.pdf","download_url":"https://www.academia.edu/attachments/31845183/download_file","bulk_download_file_name":"31845183.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/31845183/%D8%AD%D8%A8_%D9%83%D8%A7%D8%B0%D8%A8-libre.pdf?1391473585=\u0026response-content-disposition=attachment%3B+filename%3D31845183.pdf\u0026Expires=1739931654\u0026Signature=V0xGAc6dBBqlLcMaDYU88jiPc2QKf36Mf34ofXJqAqZEwuk2DK8uybj2RJ1qqXlMTq8bL7GUFMI37sGE3zV3gGnQ767v1phPaVrsSNTyWSKuPLw~t3U2s6jTtAq7ZniyTIRZ3PuDIjn0oRdNHjOcPdCCvr-wxJMTpcHE1K0~rYj~sSA3InFWASW2ZC3z4g5L7CsEKhWLt7ICN1Bz2~bmqokQpRIavgI9vwgl4-G~vK2~Ndx964LHDHD6AspsiP4IhY3-SOvTlvgK8KNigcmFmcyuVmBjOX1yavuglof~uJDMtxoFyRr40q5wZLA0cbTTEHvK2MQzU5fJZOHw-XBGfA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4423746"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4423746/%D8%AC%D9%85%D8%A7%D9%84_%D9%84%D9%83%D9%84_%D8%A7%D9%84%D9%88%D8%AA%D8%A7%D9%86"><img alt="Research paper thumbnail of جمال لكل الوتان " class="work-thumbnail" src="https://attachments.academia-assets.com/31845162/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4423746/%D8%AC%D9%85%D8%A7%D9%84_%D9%84%D9%83%D9%84_%D8%A7%D9%84%D9%88%D8%AA%D8%A7%D9%86">جمال لكل الوتان </a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="94d2d94655e8a684185e81033fd782d6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31845162,"asset_id":4423746,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31845162/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4423746"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4423746"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4423746; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4423735"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4423735/%D8%A7%D9%84%D9%82%D9%8A%D8%A7%D8%AF%D8%A9"><img alt="Research paper thumbnail of القيادة " class="work-thumbnail" src="https://attachments.academia-assets.com/31845154/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4423735/%D8%A7%D9%84%D9%82%D9%8A%D8%A7%D8%AF%D8%A9">القيادة </a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0d01f8768be094c4a66c104caeb397b1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31845154,"asset_id":4423735,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31845154/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4423735"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4423735"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4423735; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4423735]").text(description); $(".js-view-count[data-work-id=4423735]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4423735; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4423735']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4423709"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4423709/%D8%A7%D8%AD%D9%84%D8%A7%D9%85_%D8%A7%D9%84%D9%86%D9%87%D9%8A"><img alt="Research paper thumbnail of احلام النهي " class="work-thumbnail" src="https://attachments.academia-assets.com/31845133/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4423709/%D8%A7%D8%AD%D9%84%D8%A7%D9%85_%D8%A7%D9%84%D9%86%D9%87%D9%8A">احلام النهي </a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f6e7e21cc9e0c935f7fa48fee470810e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31845133,"asset_id":4423709,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31845133/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4423709"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4423709"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4423709; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4423709]").text(description); $(".js-view-count[data-work-id=4423709]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4423709; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4423709']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="2210868"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/2210868/%D8%AA%D8%AD%D8%AA_%D8%B1%D8%B0%D8%A7%D8%B0_%D8%A7%D9%84%D9%85%D8%B7%D8%B1_%D8%A8%D9%82%D9%84%D9%85_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D9%83%D9%84%D9%8A%D9%87_%D8%A7%D9%84%D8%B9%D9%84%D9%88%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7"><img alt="Research paper thumbnail of تحت رذاذ المطر بقلم د. محمد لبيب سالم كليه العلوم- جامعة طنطا" class="work-thumbnail" src="https://attachments.academia-assets.com/30260919/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2210868/%D8%AA%D8%AD%D8%AA_%D8%B1%D8%B0%D8%A7%D8%B0_%D8%A7%D9%84%D9%85%D8%B7%D8%B1_%D8%A8%D9%82%D9%84%D9%85_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D9%83%D9%84%D9%8A%D9%87_%D8%A7%D9%84%D8%B9%D9%84%D9%88%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7">تحت رذاذ المطر بقلم د. محمد لبيب سالم كليه العلوم- جامعة طنطا</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="603765ed7a51595aad4e4ed45cc5ca4e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":30260919,"asset_id":2210868,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/30260919/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="2210868"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="2210868"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 2210868; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="2210802"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/2210802/%D8%A7%D9%83%D8%B3%D9%8A%D9%80%D9%80%D8%B1_%D8%A7%D9%84%D8%A3%D9%8A%D8%A7%D9%85_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D8%A3%D8%B3%D8%AA%D8%A7%D8%B0_%D8%A7%D9%84%D9%85%D9%86%D8%A7%D8%B9%D8%A9_%D9%83%D9%84%D9%8A%D8%A9_%D8%A7%D9%84%D8%B9%D9%84%D9%88%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7"><img alt="Research paper thumbnail of اكسيــر الأيام د. محمد لبيب سالم أستاذ المناعة - كلية العلوم- جامعة طنطا" class="work-thumbnail" src="https://attachments.academia-assets.com/30260858/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2210802/%D8%A7%D9%83%D8%B3%D9%8A%D9%80%D9%80%D8%B1_%D8%A7%D9%84%D8%A3%D9%8A%D8%A7%D9%85_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D8%A3%D8%B3%D8%AA%D8%A7%D8%B0_%D8%A7%D9%84%D9%85%D9%86%D8%A7%D8%B9%D8%A9_%D9%83%D9%84%D9%8A%D8%A9_%D8%A7%D9%84%D8%B9%D9%84%D9%88%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7">اكسيــر الأيام د. محمد لبيب سالم أستاذ المناعة - كلية العلوم- جامعة طنطا</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="139db08073428d7199859bfc9667f742" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":30260858,"asset_id":2210802,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/30260858/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="2210802"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="2210802"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 2210802; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="2210426"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/2210426/%D9%88%D8%AF%D8%A7%D8%B9%D8%A9_%D9%88%D9%82%D9%88%D9%87_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D9%83%D9%84%D9%8A%D9%87_%D8%A7%D9%84%D8%B9%D9%84%D9%88%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7"><img alt="Research paper thumbnail of وداعة وقوه- د. محمد لبيب سالم كليه العلوم- جامعة طنطا" class="work-thumbnail" src="https://attachments.academia-assets.com/30260490/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2210426/%D9%88%D8%AF%D8%A7%D8%B9%D8%A9_%D9%88%D9%82%D9%88%D9%87_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D9%83%D9%84%D9%8A%D9%87_%D8%A7%D9%84%D8%B9%D9%84%D9%88%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7">وداعة وقوه- د. محمد لبيب سالم كليه العلوم- جامعة طنطا</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c9510c97d84fd4c9c1314dce1e908c50" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":30260490,"asset_id":2210426,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/30260490/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="2210426"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="2210426"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 2210426; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="2210408"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/2210408/%D9%87%D9%8A_%D9%88%D9%87%D9%88_%D9%88%D8%A7%D9%86%D8%A7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D9%83%D9%84%D9%8A%D9%87_%D8%A7%D9%84%D8%B9%D9%84%D9%88%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7_%D9%85%D8%A7%D9%8A%D9%88_%D9%A2%D9%A0%D9%A1%D9%A2"><img alt="Research paper thumbnail of هي وهو وانا د. محمد لبيب سالم كليه العلوم- جامعة طنطا مايو ٢٠١٢" class="work-thumbnail" src="https://attachments.academia-assets.com/30260477/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2210408/%D9%87%D9%8A_%D9%88%D9%87%D9%88_%D9%88%D8%A7%D9%86%D8%A7_%D8%AF_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D9%83%D9%84%D9%8A%D9%87_%D8%A7%D9%84%D8%B9%D9%84%D9%88%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7_%D9%85%D8%A7%D9%8A%D9%88_%D9%A2%D9%A0%D9%A1%D9%A2">هي وهو وانا د. محمد لبيب سالم كليه العلوم- جامعة طنطا مايو ٢٠١٢</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ec74fb759732ec57edfa96dc0b0acf22" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":30260477,"asset_id":2210408,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/30260477/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="2210408"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="2210408"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 2210408; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=2210408]").text(description); $(".js-view-count[data-work-id=2210408]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 2210408; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='2210408']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="2210336"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/2210336/%D8%A7%D9%84%D8%A5%D9%86%D8%B3%D8%A7%D9%86_%D9%88%D8%B1%D8%AD%D9%8A_%D8%A7%D9%84%D9%84%D9%8A%D9%84_%D9%88_%D8%A7%D9%84%D9%86%D9%87%D8%A7%D8%B1_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D9%83%D9%84%D9%8A%D9%87_%D8%A7%D9%84%D8%B9%D9%84%D9%88%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7_%D9%81%D9%8A_%D8%B5%D9%8A%D9%81_1998"><img alt="Research paper thumbnail of الإنسان ورحي الليل و النهار محمد لبيب سالم كليه العلوم- جامعة طنطا في صيف 1998 " class="work-thumbnail" src="https://attachments.academia-assets.com/30260360/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2210336/%D8%A7%D9%84%D8%A5%D9%86%D8%B3%D8%A7%D9%86_%D9%88%D8%B1%D8%AD%D9%8A_%D8%A7%D9%84%D9%84%D9%8A%D9%84_%D9%88_%D8%A7%D9%84%D9%86%D9%87%D8%A7%D8%B1_%D9%85%D8%AD%D9%85%D8%AF_%D9%84%D8%A8%D9%8A%D8%A8_%D8%B3%D8%A7%D9%84%D9%85_%D9%83%D9%84%D9%8A%D9%87_%D8%A7%D9%84%D8%B9%D9%84%D9%88%D9%85_%D8%AC%D8%A7%D9%85%D8%B9%D8%A9_%D8%B7%D9%86%D8%B7%D8%A7_%D9%81%D9%8A_%D8%B5%D9%8A%D9%81_1998">الإنسان ورحي الليل و النهار محمد لبيب سالم كليه العلوم- جامعة طنطا في صيف 1998 </a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3a97c082049e0e355e802e68fc6354b5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":30260360,"asset_id":2210336,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/30260360/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="2210336"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="2210336"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 2210336; 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