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href="https://www.academia.edu/14244387/Initial_clinical_experience_with_a_remote_magnetic_catheter_navigation_system_for_ablation_of_cavotricuspid_isthmus_dependent_right_atrial_flutter">Initial clinical experience with a remote magnetic catheter navigation system for ablation of cavotricuspid isthmus-dependent right atrial flutter</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A remote magnetic navigation system (MNS) is available and has been used with a 4-mm-tip magnetic catheter for radiofrequency (RF) ablation of some supraventricular and ventricular arrhythmias; however, it has not been evaluated for the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14244387" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A remote magnetic navigation system (MNS) is available and has been used with a 4-mm-tip magnetic catheter for radiofrequency (RF) ablation of some supraventricular and ventricular arrhythmias; however, it has not been evaluated for the ablation of cavotricuspid isthmus-dependent right atrial flutter (AFL). The present study evaluates the feasibility and efficiency of this system and the newly available 8-mm-tip magnetic catheter to perform RF ablation in patients with AFL. Twenty-six consecutive patients (23 men, mean age 64.6 +/- 9.6 years) underwent RF ablation using a remote MNS. RF ablation was performed with an 8-mm-tip magnetic catheter (70 degrees C, maximum power 70 W, 90 seconds). The endpoint of ablation was complete bidirectional isthmus block. To assess a possible learning curve, procedural data were compared between the first 14 (group 1) and the rest (group 2) of the patients. The initial rhythm during ablation was AFL in 20 (19 counterclockwise and 1 clockwise) and s...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14244387" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a79245034e69ff0f3fc2838dff1152ad" rel="nofollow" data-download="{"attachment_id":44411339,"asset_id":14244387,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44411339/download_file?st=MTczMjQ5MzY0OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33215043" href="https://independent.academia.edu/ArashArya">Arash Arya</a><script data-card-contents-for-user="33215043" type="text/json">{"id":33215043,"first_name":"Arash","last_name":"Arya","domain_name":"independent","page_name":"ArashArya","display_name":"Arash Arya","profile_url":"https://independent.academia.edu/ArashArya?f_ri=1131","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14244387 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14244387"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14244387, container: ".js-paper-rank-work_14244387", }); 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The present study evaluates the feasibility and efficiency of this system and the newly available 8-mm-tip magnetic catheter to perform RF ablation in patients with AFL. Twenty-six consecutive patients (23 men, mean age 64.6 +/- 9.6 years) underwent RF ablation using a remote MNS. RF ablation was performed with an 8-mm-tip magnetic catheter (70 degrees C, maximum power 70 W, 90 seconds). The endpoint of ablation was complete bidirectional isthmus block. To assess a possible learning curve, procedural data were compared between the first 14 (group 1) and the rest (group 2) of the patients. 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})();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_69956794" data-work_id="69956794" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/69956794/Studies_examining_the_efficacy_of_Ankle_Foot_Orthoses_should_report_activity_level_and_mechanical_evidence">Studies examining the efficacy of Ankle Foot Orthoses should report activity level and mechanical evidence</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Ankle Foot Orthoses (AFOs) to promote walking ability are a common treatment in patients with neurological or muscular diseases. However, guidelines on the prescription of AFOs are currently based on a low level of evidence regarding... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_69956794" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Ankle Foot Orthoses (AFOs) to promote walking ability are a common treatment in patients with neurological or muscular diseases. However, guidelines on the prescription of AFOs are currently based on a low level of evidence regarding their efficacy. Recent studies aiming to demonstrate the efficacy of wearing an AFO in respect to walking ability are not always conclusive. In this paper it is argued to recognize two levels of evidence related to the ICF levels. Activity level evidence expresses the gain in walking ability for the patient, while mechanical evidence expresses the correct functioning of the AFO. Used in combination for the purpose of evaluating the efficacy of orthotic treatment, a conjunct improvement at both levels reinforces the treatment algorithm that is used. Conversely, conflicting outcomes will challenge current treatment algorithms and the supposed working mechanism of the AFO. A treatment algorithm must use relevant information as an input, derived from measur...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/69956794" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="497c1510e0ebdc4ba74aeed7ad2e18bf" rel="nofollow" data-download="{"attachment_id":79858248,"asset_id":69956794,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/79858248/download_file?st=MTczMjQ5MzY0OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="119381828" href="https://independent.academia.edu/fholtkamp">fred holtkamp</a><script data-card-contents-for-user="119381828" type="text/json">{"id":119381828,"first_name":"fred","last_name":"holtkamp","domain_name":"independent","page_name":"fholtkamp","display_name":"fred holtkamp","profile_url":"https://independent.academia.edu/fholtkamp?f_ri=1131","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_69956794 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="69956794"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 69956794, container: ".js-paper-rank-work_69956794", }); 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However, guidelines on the prescription of AFOs are currently based on a low level of evidence regarding their efficacy. Recent studies aiming to demonstrate the efficacy of wearing an AFO in respect to walking ability are not always conclusive. In this paper it is argued to recognize two levels of evidence related to the ICF levels. Activity level evidence expresses the gain in walking ability for the patient, while mechanical evidence expresses the correct functioning of the AFO. Used in combination for the purpose of evaluating the efficacy of orthotic treatment, a conjunct improvement at both levels reinforces the treatment algorithm that is used. Conversely, conflicting outcomes will challenge current treatment algorithms and the supposed working mechanism of the AFO. A treatment algorithm must use relevant information as an input, derived from measur...","downloadable_attachments":[{"id":79858248,"asset_id":69956794,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":119381828,"first_name":"fred","last_name":"holtkamp","domain_name":"independent","page_name":"fholtkamp","display_name":"fred holtkamp","profile_url":"https://independent.academia.edu/fholtkamp?f_ri=1131","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=1131","nofollow":false},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false},{"id":3645,"name":"Evidence Based Medicine","url":"https://www.academia.edu/Documents/in/Evidence_Based_Medicine?f_ri=1131","nofollow":false},{"id":12426,"name":"Treatment 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The importance of the anatomical and physiological understanding of nerve tissue in the surgical repair of nerve injuries is discussed. This includes an... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_19151298" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The anatomy and physiology of nerve tissue and the peripheral nerve are reviewed. The importance of the anatomical and physiological understanding of nerve tissue in the surgical repair of nerve injuries is discussed. This includes an outline of the light and electron microscopic histology of nerve and a short review of axoplasmic flow. In addition, the nerve coverings, endoneurium, perineurium, and epineurium, are described. The relationship of these coverings to the surgical therapy of nerve injuries is outlined. By maintaining, where possible, nerve fascicle continuity and by restoring, where practical, the normal physiology of distorted but not disrupted fascicles, with the use of careful internal neurolysis, optimal clinical return of function should be achieved.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19151298" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0a0e1fdce45ad30a8c331d7fc71196c4" rel="nofollow" data-download="{"attachment_id":42107543,"asset_id":19151298,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42107543/download_file?st=MTczMjQ5MzY0OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39347880" href="https://univ-grenoble-alpes.academia.edu/JeanphilippeGiot">Jean-philippe Giot</a><script data-card-contents-for-user="39347880" type="text/json">{"id":39347880,"first_name":"Jean-philippe","last_name":"Giot","domain_name":"univ-grenoble-alpes","page_name":"JeanphilippeGiot","display_name":"Jean-philippe Giot","profile_url":"https://univ-grenoble-alpes.academia.edu/JeanphilippeGiot?f_ri=1131","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_19151298 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19151298"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 19151298, container: ".js-paper-rank-work_19151298", }); 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processing","url":"https://www.academia.edu/Documents/in/Biomedical_signal_and_image_processing?f_ri=1131","nofollow":false},{"id":22161,"name":"Electronics and biomedical engineering","url":"https://www.academia.edu/Documents/in/Electronics_and_biomedical_engineering?f_ri=1131","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13080051" data-work_id="13080051" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13080051/The_return_of_a_forgotten_polymer_Polycaprolactone_in_the_21st_century">The return of a forgotten polymer—Polycaprolactone in the 21st century</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div 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data-card-contents-for-ri="1131" type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8270" href="https://www.academia.edu/Documents/in/Forecasting">Forecasting</a>, <script data-card-contents-for-ri="8270" type="text/json">{"id":8270,"name":"Forecasting","url":"https://www.academia.edu/Documents/in/Forecasting?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9054" href="https://www.academia.edu/Documents/in/Temporomandibular_Joint">Temporomandibular Joint</a><script data-card-contents-for-ri="9054" type="text/json">{"id":9054,"name":"Temporomandibular Joint","url":"https://www.academia.edu/Documents/in/Temporomandibular_Joint?f_ri=1131","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: 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Esthetics","url":"https://www.academia.edu/Documents/in/Dental_Esthetics?f_ri=1131"},{"id":1727064,"name":"Chin","url":"https://www.academia.edu/Documents/in/Chin?f_ri=1131"},{"id":2191496,"name":"Prognathism","url":"https://www.academia.edu/Documents/in/Prognathism?f_ri=1131"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_8560004" data-work_id="8560004" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/8560004/Prosthodontic_management_of_edentulous_patient_with_limited_oral_access_using_implant_supported_prostheses_A_clinical_report">Prosthodontic management of edentulous patient with limited oral access using implant-supported prostheses: A clinical report</a></div></div><div class="u-pb4x u-mt3x"></div><ul 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href="https://www.academia.edu/Documents/in/Dentistry">Dentistry</a>, <script data-card-contents-for-ri="596" type="text/json">{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1131" href="https://www.academia.edu/Documents/in/Biomedical_Engineering">Biomedical Engineering</a>, <script data-card-contents-for-ri="1131" type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="98925" href="https://www.academia.edu/Documents/in/Female">Female</a><script data-card-contents-for-ri="98925" type="text/json">{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=1131","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=8560004]'), work: {"id":8560004,"title":"Prosthodontic management of edentulous patient with limited oral access using implant-supported prostheses: A clinical 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href="https://www.academia.edu/29310086/Orthodontic_materials_research_and_applications_Part_2_Current_status_and_projected_future_developments_in_materials_and_biocompatibility">Orthodontic materials research and applications: Part 2. Current status and projected future developments in materials and biocompatibility</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/29310086" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d163af01351dcec7bd9981dbf3e814f0" rel="nofollow" data-download="{"attachment_id":49750565,"asset_id":29310086,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49750565/download_file?st=MTczMjQ5MzY1MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="55269546" href="https://independent.academia.edu/TheodoreEliades">Theodore Eliades</a><script data-card-contents-for-user="55269546" type="text/json">{"id":55269546,"first_name":"Theodore","last_name":"Eliades","domain_name":"independent","page_name":"TheodoreEliades","display_name":"Theodore Eliades","profile_url":"https://independent.academia.edu/TheodoreEliades?f_ri=1131","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_29310086 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="29310086"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 29310086, container: ".js-paper-rank-work_29310086", }); 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$(".js-view-count[data-work-id=29310086]").text(description); $(".js-view-count-work_29310086").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_29310086").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="29310086"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="596" href="https://www.academia.edu/Documents/in/Dentistry">Dentistry</a>, <script data-card-contents-for-ri="596" type="text/json">{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1131" href="https://www.academia.edu/Documents/in/Biomedical_Engineering">Biomedical Engineering</a>, <script data-card-contents-for-ri="1131" type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2978" href="https://www.academia.edu/Documents/in/Dental_Research">Dental Research</a>, <script data-card-contents-for-ri="2978" type="text/json">{"id":2978,"name":"Dental Research","url":"https://www.academia.edu/Documents/in/Dental_Research?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8270" href="https://www.academia.edu/Documents/in/Forecasting">Forecasting</a><script data-card-contents-for-ri="8270" type="text/json">{"id":8270,"name":"Forecasting","url":"https://www.academia.edu/Documents/in/Forecasting?f_ri=1131","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=29310086]'), work: {"id":29310086,"title":"Orthodontic materials research and applications: Part 2. 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Although there is an inclination to measure the hematocrit by determining the bioelectrical impedance of the blood, in vitro experimental methods still remain practically... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_33286352" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Measuring blood hematocrit noninvasively is reviewed in this paper. Although there is an inclination to<br />measure the hematocrit by determining the bioelectrical impedance of the blood, in vitro experimental<br />methods still remain practically inapplicable. The blood sample size is determined when blood samples<br />are examined. Determining the impedance and volume of blood is the biggest challenge in measuring<br />the hematocrit noninvasively without drawing a blood sample. Calculating the blood impedance in vivo<br />requires developing an impedance measurement using a multi-frequency method and also calculating<br />the change in pressure simultaneously during the heart’s pulsatile cycle.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/33286352" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="cb0a2b0b09ed0fc1413f2a6f4b720894" rel="nofollow" data-download="{"attachment_id":53353068,"asset_id":33286352,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/53353068/download_file?st=MTczMjQ5MzY1MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="65013486" href="https://malaya.academia.edu/Aoday">Aoday H M Alrawi</a><script data-card-contents-for-user="65013486" type="text/json">{"id":65013486,"first_name":"Aoday","last_name":"Alrawi","domain_name":"malaya","page_name":"Aoday","display_name":"Aoday H M Alrawi","profile_url":"https://malaya.academia.edu/Aoday?f_ri=1131","photo":"https://0.academia-photos.com/65013486/16911895/17132778/s65_dr-aoday.alrawi.jpg"}</script></span></span></li><li class="js-paper-rank-work_33286352 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="33286352"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 33286352, container: ".js-paper-rank-work_33286352", }); 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Although there is an inclination to\nmeasure the hematocrit by determining the bioelectrical impedance of the blood, in vitro experimental\nmethods still remain practically inapplicable. The blood sample size is determined when blood samples\nare examined. Determining the impedance and volume of blood is the biggest challenge in measuring\nthe hematocrit noninvasively without drawing a blood sample. 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However, mechanisms that mediate translation... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61430544" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Signalling interactions between the polarizing region, which produces SHH, and the apical ectodermal ridge, which produces FGFs, are essential for outgrowth and patterning of vertebrate limbs. 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type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=1131","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=3700617]'), work: {"id":3700617,"title":"BCI meeting 2005 - Workshop on Signals and Recording Methods","created_at":"2013-06-12T23:14:05.222-07:00","url":"https://www.academia.edu/3700617/BCI_meeting_2005_Workshop_on_Signals_and_Recording_Methods?f_ri=1131","dom_id":"work_3700617","summary":null,"downloadable_attachments":[{"id":50173596,"asset_id":3700617,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":4526588,"first_name":"Femke","last_name":"Nijboer","domain_name":"utwente","page_name":"FemkeNijboer","display_name":"Femke 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oxide ceramics and adhesive cement systems: A systematic review</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/54133892" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f03b56dc81c6b5d655ac421379b9add0" rel="nofollow" data-download="{"attachment_id":70645629,"asset_id":54133892,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="99234" href="https://www.academia.edu/Documents/in/Animals">Animals</a><script data-card-contents-for-ri="99234" type="text/json">{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=1131","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=54133892]'), work: {"id":54133892,"title":"Bonding between oxide ceramics and adhesive cement systems: A systematic review","created_at":"2021-09-29T22:20:05.988-07:00","url":"https://www.academia.edu/54133892/Bonding_between_oxide_ceramics_and_adhesive_cement_systems_A_systematic_review?f_ri=1131","dom_id":"work_54133892","summary":null,"downloadable_attachments":[{"id":70645629,"asset_id":54133892,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":132398417,"first_name":"Evaggelia","last_name":"Papia","domain_name":"independent","page_name":"EvaggeliaPapia","display_name":"Evaggelia Papia","profile_url":"https://independent.academia.edu/EvaggeliaPapia?f_ri=1131","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false},{"id":58128,"name":"Ceramics","url":"https://www.academia.edu/Documents/in/Ceramics?f_ri=1131","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1131","nofollow":false},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=1131","nofollow":false},{"id":250371,"name":"Bond Strength","url":"https://www.academia.edu/Documents/in/Bond_Strength?f_ri=1131"},{"id":340662,"name":"Zirconia","url":"https://www.academia.edu/Documents/in/Zirconia?f_ri=1131"},{"id":714090,"name":"Bone Cements","url":"https://www.academia.edu/Documents/in/Bone_Cements?f_ri=1131"},{"id":892969,"name":"Materials Testing","url":"https://www.academia.edu/Documents/in/Materials_Testing?f_ri=1131"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_7005983" data-work_id="7005983" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/7005983/Evolution_of_Optical_Access_Networks_Architectures_and_Capacity_Upgrades">Evolution of Optical Access Networks: Architectures and Capacity Upgrades</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Passive optical network (PON) is one of the most successful broadband access architectures being deployed worldwide. PONs provide high capacity, increased reach, and low-power consumption at a very reasonable cost, on par with the cost of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_7005983" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Passive optical network (PON) is one of the most successful broadband access architectures being deployed worldwide. PONs provide high capacity, increased reach, and low-power consumption at a very reasonable cost, on par with the cost of DSL deployments today. This paper provides an overview of present and emerging PON technologies, and discusses PON's important role in the evolution of optical access from the architectural perspective. While describing the evolution of optical access architecture, we present two important integration options: optical+wireless access integration and metro+access integration. Potential PON capacity upgrades are discussed with special emphasis on achieving a seamless upgrade. We evaluate different PON evolution strategies in the context of next-generation PON, where gradual, demand-based migration demonstrates a number of significant benefits.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7005983" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dfaff526216146c413344554550150eb" rel="nofollow" data-download="{"attachment_id":48636093,"asset_id":7005983,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48636093/download_file?st=MTczMjQ5MzY1MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11917833" href="https://ucdavis.academia.edu/PulakChowdhury">Pulak Chowdhury</a><script data-card-contents-for-user="11917833" type="text/json">{"id":11917833,"first_name":"Pulak","last_name":"Chowdhury","domain_name":"ucdavis","page_name":"PulakChowdhury","display_name":"Pulak Chowdhury","profile_url":"https://ucdavis.academia.edu/PulakChowdhury?f_ri=1131","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_7005983 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="7005983"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 7005983, container: ".js-paper-rank-work_7005983", }); 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$(".js-view-count[data-work-id=7005983]").text(description); $(".js-view-count-work_7005983").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_7005983").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="7005983"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1131" href="https://www.academia.edu/Documents/in/Biomedical_Engineering">Biomedical Engineering</a>, <script data-card-contents-for-ri="1131" type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4850" href="https://www.academia.edu/Documents/in/Migration">Migration</a>, <script data-card-contents-for-ri="4850" type="text/json">{"id":4850,"name":"Migration","url":"https://www.academia.edu/Documents/in/Migration?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10882" href="https://www.academia.edu/Documents/in/Evolution">Evolution</a>, <script data-card-contents-for-ri="10882" type="text/json">{"id":10882,"name":"Evolution","url":"https://www.academia.edu/Documents/in/Evolution?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="89123" href="https://www.academia.edu/Documents/in/Broadband_Networks">Broadband Networks</a><script data-card-contents-for-ri="89123" type="text/json">{"id":89123,"name":"Broadband Networks","url":"https://www.academia.edu/Documents/in/Broadband_Networks?f_ri=1131","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=7005983]'), work: {"id":7005983,"title":"Evolution of Optical Access Networks: Architectures and Capacity Upgrades","created_at":"2014-05-10T09:07:09.806-07:00","url":"https://www.academia.edu/7005983/Evolution_of_Optical_Access_Networks_Architectures_and_Capacity_Upgrades?f_ri=1131","dom_id":"work_7005983","summary":"Passive optical network (PON) is one of the most successful broadband access architectures being deployed worldwide. PONs provide high capacity, increased reach, and low-power consumption at a very reasonable cost, on par with the cost of DSL deployments today. This paper provides an overview of present and emerging PON technologies, and discusses PON's important role in the evolution of optical access from the architectural perspective. While describing the evolution of optical access architecture, we present two important integration options: optical+wireless access integration and metro+access integration. Potential PON capacity upgrades are discussed with special emphasis on achieving a seamless upgrade. We evaluate different PON evolution strategies in the context of next-generation PON, where gradual, demand-based migration demonstrates a number of significant benefits.","downloadable_attachments":[{"id":48636093,"asset_id":7005983,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":11917833,"first_name":"Pulak","last_name":"Chowdhury","domain_name":"ucdavis","page_name":"PulakChowdhury","display_name":"Pulak Chowdhury","profile_url":"https://ucdavis.academia.edu/PulakChowdhury?f_ri=1131","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false},{"id":4850,"name":"Migration","url":"https://www.academia.edu/Documents/in/Migration?f_ri=1131","nofollow":false},{"id":10882,"name":"Evolution","url":"https://www.academia.edu/Documents/in/Evolution?f_ri=1131","nofollow":false},{"id":89123,"name":"Broadband Networks","url":"https://www.academia.edu/Documents/in/Broadband_Networks?f_ri=1131","nofollow":false},{"id":126362,"name":"Passive Optical Networks","url":"https://www.academia.edu/Documents/in/Passive_Optical_Networks?f_ri=1131"},{"id":228334,"name":"Low Power Consumption","url":"https://www.academia.edu/Documents/in/Low_Power_Consumption?f_ri=1131"},{"id":363276,"name":"Capacity","url":"https://www.academia.edu/Documents/in/Capacity?f_ri=1131"},{"id":404996,"name":"Optical fiber","url":"https://www.academia.edu/Documents/in/Optical_fiber?f_ri=1131"},{"id":421837,"name":"Wavelength Division Multiplexing","url":"https://www.academia.edu/Documents/in/Wavelength_Division_Multiplexing?f_ri=1131"},{"id":431072,"name":"Next Generation","url":"https://www.academia.edu/Documents/in/Next_Generation?f_ri=1131"},{"id":563439,"name":"Evolution Strategy","url":"https://www.academia.edu/Documents/in/Evolution_Strategy?f_ri=1131"},{"id":756544,"name":"Broadband Access","url":"https://www.academia.edu/Documents/in/Broadband_Access?f_ri=1131"},{"id":877397,"name":"Optical Fibers","url":"https://www.academia.edu/Documents/in/Optical_Fibers?f_ri=1131"},{"id":1237788,"name":"Electrical And Electronic Engineering","url":"https://www.academia.edu/Documents/in/Electrical_And_Electronic_Engineering?f_ri=1131"},{"id":1767667,"name":"Access Network","url":"https://www.academia.edu/Documents/in/Access_Network?f_ri=1131"},{"id":1929660,"name":"Broadband Communication","url":"https://www.academia.edu/Documents/in/Broadband_Communication?f_ri=1131"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_66720925" data-work_id="66720925" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/66720925/Eight_year_follow_up_of_successful_intentional_replantation">Eight-year follow-up of successful intentional replantation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Intentional replantation has been practised for many years as a treatment modality for pulpless teeth. Although the success ratio for intentional replantation is far below that for routine or surgical endodontics, this procedure should be... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_66720925" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Intentional replantation has been practised for many years as a treatment modality for pulpless teeth. Although the success ratio for intentional replantation is far below that for routine or surgical endodontics, this procedure should be considered an alternative to tooth extraction. A case of mandibular second molars treated with intentional replantation and retrograde fillings is reported in this article. At the eight-year recall visit, radiographs showed no evidence of pathological changes.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/66720925" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="00029012ac9e143443d3db963f290a10" rel="nofollow" data-download="{"attachment_id":77803573,"asset_id":66720925,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77803573/download_file?st=MTczMjQ5MzY1MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="8979504" href="https://independent.academia.edu/muhamadabuhussein">muhamad abu-hussein</a><script data-card-contents-for-user="8979504" type="text/json">{"id":8979504,"first_name":"muhamad","last_name":"abu-hussein","domain_name":"independent","page_name":"muhamadabuhussein","display_name":"muhamad abu-hussein","profile_url":"https://independent.academia.edu/muhamadabuhussein?f_ri=1131","photo":"https://0.academia-photos.com/8979504/78261632/66810197/s65_muhamad.abu-hussein.jpeg"}</script></span></span></li><li class="js-paper-rank-work_66720925 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="66720925"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 66720925, container: ".js-paper-rank-work_66720925", }); });</script></li><li class="js-percentile-work_66720925 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66720925; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_66720925"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_66720925 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="66720925"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66720925; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66720925]").text(description); $(".js-view-count-work_66720925").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_66720925").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="66720925"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="596" href="https://www.academia.edu/Documents/in/Dentistry">Dentistry</a>, <script data-card-contents-for-ri="596" type="text/json">{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1131" href="https://www.academia.edu/Documents/in/Biomedical_Engineering">Biomedical Engineering</a><script data-card-contents-for-ri="1131" type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=66720925]'), work: {"id":66720925,"title":"Eight-year follow-up of successful intentional replantation","created_at":"2021-12-31T08:27:56.181-08:00","url":"https://www.academia.edu/66720925/Eight_year_follow_up_of_successful_intentional_replantation?f_ri=1131","dom_id":"work_66720925","summary":"Intentional replantation has been practised for many years as a treatment modality for pulpless teeth. Although the success ratio for intentional replantation is far below that for routine or surgical endodontics, this procedure should be considered an alternative to tooth extraction. A case of mandibular second molars treated with intentional replantation and retrograde fillings is reported in this article. At the eight-year recall visit, radiographs showed no evidence of pathological changes.","downloadable_attachments":[{"id":77803573,"asset_id":66720925,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":8979504,"first_name":"muhamad","last_name":"abu-hussein","domain_name":"independent","page_name":"muhamadabuhussein","display_name":"muhamad abu-hussein","profile_url":"https://independent.academia.edu/muhamadabuhussein?f_ri=1131","photo":"https://0.academia-photos.com/8979504/78261632/66810197/s65_muhamad.abu-hussein.jpeg"}],"research_interests":[{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=1131","nofollow":false},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_32927943" data-work_id="32927943" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/32927943/Organ_on_a_chip_platforms_for_studying_drug_delivery_systems">Organ-on-a-chip platforms for studying drug delivery systems</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Novel microfluidic tools allow new ways to manufacture and test drug delivery systems. Organ-on-a-chip systems - microscale recapitulations of complex organ functions - promise to improve the drug development pipeline. This review... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_32927943" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Novel microfluidic tools allow new ways to manufacture and test drug delivery systems. Organ-on-a-chip systems - microscale recapitulations of complex organ functions - promise to improve the drug development pipeline. This review highlights the importance of integrating microfluidic networks with 3D tissue engineered models to create organ-on-a-chip platforms, able to meet the demand of creating robust preclinical screening models. Specific examples are cited to demonstrate the use of these systems for studying the performance of drug delivery vectors and thereby reduce the discrepancies between their performance at preclinical and clinical trials. We also highlight the future directions that need to be pursued by the research community for these proof-of-concept studies to achieve the goal of accelerating clinical translation of drug delivery nanoparticles.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/32927943" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5058606de6b2b7cbe73426feebd14288" rel="nofollow" data-download="{"attachment_id":53061866,"asset_id":32927943,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/53061866/download_file?st=MTczMjQ5MzY1MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="64033575" href="https://independent.academia.edu/MassaSolange">Solange Massa</a><script data-card-contents-for-user="64033575" type="text/json">{"id":64033575,"first_name":"Solange","last_name":"Massa","domain_name":"independent","page_name":"MassaSolange","display_name":"Solange Massa","profile_url":"https://independent.academia.edu/MassaSolange?f_ri=1131","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_32927943 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="32927943"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 32927943, container: ".js-paper-rank-work_32927943", }); 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Organ-on-a-chip systems - microscale recapitulations of complex organ functions - promise to improve the drug development pipeline. This review highlights the importance of integrating microfluidic networks with 3D tissue engineered models to create organ-on-a-chip platforms, able to meet the demand of creating robust preclinical screening models. Specific examples are cited to demonstrate the use of these systems for studying the performance of drug delivery vectors and thereby reduce the discrepancies between their performance at preclinical and clinical trials. We also highlight the future directions that need to be pursued by the research community for these proof-of-concept studies to achieve the goal of accelerating clinical translation of drug delivery nanoparticles.","downloadable_attachments":[{"id":53061866,"asset_id":32927943,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":64033575,"first_name":"Solange","last_name":"Massa","domain_name":"independent","page_name":"MassaSolange","display_name":"Solange Massa","profile_url":"https://independent.academia.edu/MassaSolange?f_ri=1131","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false},{"id":2721,"name":"Microfluidics","url":"https://www.academia.edu/Documents/in/Microfluidics?f_ri=1131","nofollow":false},{"id":10640,"name":"Drug Discovery","url":"https://www.academia.edu/Documents/in/Drug_Discovery?f_ri=1131","nofollow":false},{"id":13621,"name":"Nanoparticles","url":"https://www.academia.edu/Documents/in/Nanoparticles?f_ri=1131","nofollow":false},{"id":64660,"name":"Controlled release","url":"https://www.academia.edu/Documents/in/Controlled_release?f_ri=1131"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems?f_ri=1131"},{"id":392067,"name":"Biomimetic materials","url":"https://www.academia.edu/Documents/in/Biomimetic_materials?f_ri=1131"},{"id":1031068,"name":"Drug Carriers","url":"https://www.academia.edu/Documents/in/Drug_Carriers?f_ri=1131"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14729493" data-work_id="14729493" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14729493/Organ_on_a_chip_platforms_for_studying_drug_delivery_systems">Organ-on-a-chip platforms for studying drug delivery systems</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Novel microfluidic tools allow new ways to manufacture and test drug delivery systems. Organ-on-a-chip systems - microscale recapitulations of complex organ functions - promise to improve the drug development pipeline. This review... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14729493" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Novel microfluidic tools allow new ways to manufacture and test drug delivery systems. Organ-on-a-chip systems - microscale recapitulations of complex organ functions - promise to improve the drug development pipeline. This review highlights the importance of integrating microfluidic networks with 3D tissue engineered models to create organ-on-a-chip platforms, able to meet the demand of creating robust preclinical screening models. Specific examples are cited to demonstrate the use of these systems for studying the performance of drug delivery vectors and thereby reduce the discrepancies between their performance at preclinical and clinical trials. We also highlight the future directions that need to be pursued by the research community for these proof-of-concept studies to achieve the goal of accelerating clinical translation of drug delivery nanoparticles.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14729493" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2fbae5a99f0ff18760ed31e3c234fab5" rel="nofollow" data-download="{"attachment_id":43936505,"asset_id":14729493,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43936505/download_file?st=MTczMjQ5MzY1MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33690164" href="https://hms-harvard.academia.edu/MDokmeci">Mehmet Dokmeci</a><script data-card-contents-for-user="33690164" type="text/json">{"id":33690164,"first_name":"Mehmet","last_name":"Dokmeci","domain_name":"hms-harvard","page_name":"MDokmeci","display_name":"Mehmet Dokmeci","profile_url":"https://hms-harvard.academia.edu/MDokmeci?f_ri=1131","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14729493 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14729493"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14729493, container: ".js-paper-rank-work_14729493", }); 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$(".js-view-count[data-work-id=14729493]").text(description); $(".js-view-count-work_14729493").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14729493").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14729493"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1131" href="https://www.academia.edu/Documents/in/Biomedical_Engineering">Biomedical Engineering</a>, <script data-card-contents-for-ri="1131" type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2721" href="https://www.academia.edu/Documents/in/Microfluidics">Microfluidics</a>, <script data-card-contents-for-ri="2721" type="text/json">{"id":2721,"name":"Microfluidics","url":"https://www.academia.edu/Documents/in/Microfluidics?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10640" href="https://www.academia.edu/Documents/in/Drug_Discovery">Drug Discovery</a>, <script data-card-contents-for-ri="10640" type="text/json">{"id":10640,"name":"Drug Discovery","url":"https://www.academia.edu/Documents/in/Drug_Discovery?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="13621" href="https://www.academia.edu/Documents/in/Nanoparticles">Nanoparticles</a><script data-card-contents-for-ri="13621" type="text/json">{"id":13621,"name":"Nanoparticles","url":"https://www.academia.edu/Documents/in/Nanoparticles?f_ri=1131","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14729493]'), work: {"id":14729493,"title":"Organ-on-a-chip platforms for studying drug delivery systems","created_at":"2015-08-06T21:10:35.666-07:00","url":"https://www.academia.edu/14729493/Organ_on_a_chip_platforms_for_studying_drug_delivery_systems?f_ri=1131","dom_id":"work_14729493","summary":"Novel microfluidic tools allow new ways to manufacture and test drug delivery systems. Organ-on-a-chip systems - microscale recapitulations of complex organ functions - promise to improve the drug development pipeline. This review highlights the importance of integrating microfluidic networks with 3D tissue engineered models to create organ-on-a-chip platforms, able to meet the demand of creating robust preclinical screening models. Specific examples are cited to demonstrate the use of these systems for studying the performance of drug delivery vectors and thereby reduce the discrepancies between their performance at preclinical and clinical trials. We also highlight the future directions that need to be pursued by the research community for these proof-of-concept studies to achieve the goal of accelerating clinical translation of drug delivery nanoparticles.","downloadable_attachments":[{"id":43936505,"asset_id":14729493,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33690164,"first_name":"Mehmet","last_name":"Dokmeci","domain_name":"hms-harvard","page_name":"MDokmeci","display_name":"Mehmet Dokmeci","profile_url":"https://hms-harvard.academia.edu/MDokmeci?f_ri=1131","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false},{"id":2721,"name":"Microfluidics","url":"https://www.academia.edu/Documents/in/Microfluidics?f_ri=1131","nofollow":false},{"id":10640,"name":"Drug Discovery","url":"https://www.academia.edu/Documents/in/Drug_Discovery?f_ri=1131","nofollow":false},{"id":13621,"name":"Nanoparticles","url":"https://www.academia.edu/Documents/in/Nanoparticles?f_ri=1131","nofollow":false},{"id":64660,"name":"Controlled release","url":"https://www.academia.edu/Documents/in/Controlled_release?f_ri=1131"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems?f_ri=1131"},{"id":392067,"name":"Biomimetic materials","url":"https://www.academia.edu/Documents/in/Biomimetic_materials?f_ri=1131"},{"id":1031068,"name":"Drug Carriers","url":"https://www.academia.edu/Documents/in/Drug_Carriers?f_ri=1131"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13631811" data-work_id="13631811" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13631811/Schwartzs_Principles_of_Surgery_10th_Ed">Schwartzs Principles of Surgery, 10th Ed</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13631811" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d6c24fd1ec1ab1e269c36edeb765ab04" rel="nofollow" data-download="{"attachment_id":38092346,"asset_id":13631811,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm 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href="https://www.academia.edu/Documents/in/Physiology">Physiology</a>, <script data-card-contents-for-ri="167" type="text/json">{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="168" href="https://www.academia.edu/Documents/in/Human_Physiology">Human Physiology</a><script data-card-contents-for-ri="168" type="text/json">{"id":168,"name":"Human Physiology","url":"https://www.academia.edu/Documents/in/Human_Physiology?f_ri=1131","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13631811]'), work: {"id":13631811,"title":"Schwartzs Principles of Surgery, 10th 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u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24496405/Effects_of_task_oriented_robot_training_on_arm_function_activity_and_quality_of_life_in_chronic_stroke_patients_a_randomized_controlled_trial">Effects of task-oriented robot training on arm function, activity, and quality of life in chronic stroke patients: a randomized controlled trial</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24496405" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9acb051a3a7cdb889931b94521b5a0b6" rel="nofollow" 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href="https://www.academia.edu/Documents/in/Biomedical_Engineering">Biomedical Engineering</a>, <script data-card-contents-for-ri="1131" type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="11200" href="https://www.academia.edu/Documents/in/Nuclear_Medicine_Physics">Nuclear Medicine Physics</a>, <script data-card-contents-for-ri="11200" type="text/json">{"id":11200,"name":"Nuclear Medicine Physics","url":"https://www.academia.edu/Documents/in/Nuclear_Medicine_Physics?f_ri=1131","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1131","nofollow":false}</script><a 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