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Follow-up studies Research Papers - Academia.edu
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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Follow-up studies</h1><div class="u-tcGrayDark">16,612 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Follow-up studies</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Follow-up_studies">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Follow-up_studies/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Follow-up_studies/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Follow-up_studies/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Follow-up_studies">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24519983 coauthored" data-work_id="24519983" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24519983/Application_of_endograft_to_treat_thoracic_aortic_pathologies_A_single_center_experience">Application of endograft to treat thoracic aortic pathologies: A single center experience</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose: To evaluate our experience of thoracic endoluminal graft (ELG) repair of various thoracic aortic pathologies using a commercially available device approved by the Food and Drug Administration. Our patient population includes... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24519983" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose: To evaluate our experience of thoracic endoluminal graft (ELG) repair of various thoracic aortic pathologies using a commercially available device approved by the Food and Drug Administration. Our patient population includes patients eligible for open surgical repair and those with prohibitive surgical risk. Methods: From March 1998 to March 2006, endovascular stent repair of the thoracic aorta was performed on 406 patients with 324 patients (median age 72; 200 male) receiving the Gore Excluder endograft. Patient demographics, procedural characteristics, complications, including endoleak, spinal cord ischemia, and mortality, were retrospectively reviewed during follow-up. All patients were followed with chest computer tomography at 6 months and yearly. Statistical analysis was performed utilizing the SPSS Windows 11.0 program. Logistic regression (univariate) analysis used to identify risk factors for paraplegia; analysis of variance (ANOVA) for endoleak distribution; and 2 used to analyze variables. Survival analysis was done using SAS version 9.1 (SAS Institute, Cary, NC). Results: Three hundred twenty-four patients were treated with Gore Excluder graft between March 1998 and March 2006. One hundred fifty-seven patients (48.5%) had atherosclerotic aneurysms, 82 (25.3%) had dissections type B (DTB), 34 (10.5%) had penetrating ulcers (PU), 26 (8.0%) with pseudoaneurysms (PSA), 11 (3.4%) had transections (MVAT), 9 (2.8%) aorto-bronchial fistulas (AoBF), 4 (1.2%) embolization, and 1 (0.3%) aorto-esophageal fistula (AoEF). Preoperative aneurysm sac size in TAA ranged from 5 to 12 centimeters, average size 6.3 cm. Sac shrinkage occurred in 65% (102 of 157) of patients. Average postoperative sac size of 5.4 cm in a mean follow-up of 20.4 months. One hundred cases (31.5%) were nonelective; 49 (15.1%) were ruptures. Overall complication was 22.7%, 14.2% (46) in elective cases and 8.5% (28) in nonelective cases.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24519983" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a45a8ecc59bd8b62ea5fa2608298c31e" rel="nofollow" data-download="{"attachment_id":44851387,"asset_id":24519983,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44851387/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33098087" href="https://temple.academia.edu/GraysonWheatley">Grayson Wheatley</a><script data-card-contents-for-user="33098087" type="text/json">{"id":33098087,"first_name":"Grayson","last_name":"Wheatley","domain_name":"temple","page_name":"GraysonWheatley","display_name":"Grayson Wheatley","profile_url":"https://temple.academia.edu/GraysonWheatley?f_ri=137516","photo":"https://0.academia-photos.com/33098087/12473525/13881272/s65_grayson.wheatley.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-24519983">+2</span><div class="hidden js-additional-users-24519983"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/DawnOlsen">Dawn Olsen</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/LeonardoAquiarLucas">Leonardo Aquiar-Lucas</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-24519983'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-24519983').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_24519983 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24519983"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24519983, container: ".js-paper-rank-work_24519983", }); });</script></li><li class="js-percentile-work_24519983 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24519983; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24519983"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24519983 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24519983"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24519983; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24519983]").text(description); $(".js-view-count-work_24519983").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24519983").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24519983"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">9</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="25398" rel="nofollow" href="https://www.academia.edu/Documents/in/Vascular_Surgery">Vascular Surgery</a>, <script data-card-contents-for-ri="25398" type="text/json">{"id":25398,"name":"Vascular Surgery","url":"https://www.academia.edu/Documents/in/Vascular_Surgery?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a>, <script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="228722" rel="nofollow" href="https://www.academia.edu/Documents/in/Vascular">Vascular</a><script data-card-contents-for-ri="228722" type="text/json">{"id":228722,"name":"Vascular","url":"https://www.academia.edu/Documents/in/Vascular?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24519983]'), work: {"id":24519983,"title":"Application of endograft to treat thoracic aortic pathologies: A single center experience","created_at":"2016-04-18T05:04:51.635-07:00","url":"https://www.academia.edu/24519983/Application_of_endograft_to_treat_thoracic_aortic_pathologies_A_single_center_experience?f_ri=137516","dom_id":"work_24519983","summary":"Purpose: To evaluate our experience of thoracic endoluminal graft (ELG) repair of various thoracic aortic pathologies using a commercially available device approved by the Food and Drug Administration. Our patient population includes patients eligible for open surgical repair and those with prohibitive surgical risk. Methods: From March 1998 to March 2006, endovascular stent repair of the thoracic aorta was performed on 406 patients with 324 patients (median age 72; 200 male) receiving the Gore Excluder endograft. Patient demographics, procedural characteristics, complications, including endoleak, spinal cord ischemia, and mortality, were retrospectively reviewed during follow-up. All patients were followed with chest computer tomography at 6 months and yearly. Statistical analysis was performed utilizing the SPSS Windows 11.0 program. Logistic regression (univariate) analysis used to identify risk factors for paraplegia; analysis of variance (ANOVA) for endoleak distribution; and 2 used to analyze variables. Survival analysis was done using SAS version 9.1 (SAS Institute, Cary, NC). Results: Three hundred twenty-four patients were treated with Gore Excluder graft between March 1998 and March 2006. One hundred fifty-seven patients (48.5%) had atherosclerotic aneurysms, 82 (25.3%) had dissections type B (DTB), 34 (10.5%) had penetrating ulcers (PU), 26 (8.0%) with pseudoaneurysms (PSA), 11 (3.4%) had transections (MVAT), 9 (2.8%) aorto-bronchial fistulas (AoBF), 4 (1.2%) embolization, and 1 (0.3%) aorto-esophageal fistula (AoEF). Preoperative aneurysm sac size in TAA ranged from 5 to 12 centimeters, average size 6.3 cm. Sac shrinkage occurred in 65% (102 of 157) of patients. Average postoperative sac size of 5.4 cm in a mean follow-up of 20.4 months. One hundred cases (31.5%) were nonelective; 49 (15.1%) were ruptures. Overall complication was 22.7%, 14.2% (46) in elective cases and 8.5% (28) in nonelective cases.","downloadable_attachments":[{"id":44851387,"asset_id":24519983,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33098087,"first_name":"Grayson","last_name":"Wheatley","domain_name":"temple","page_name":"GraysonWheatley","display_name":"Grayson Wheatley","profile_url":"https://temple.academia.edu/GraysonWheatley?f_ri=137516","photo":"https://0.academia-photos.com/33098087/12473525/13881272/s65_grayson.wheatley.jpg"},{"id":43285029,"first_name":"Dawn","last_name":"Olsen","domain_name":"independent","page_name":"DawnOlsen","display_name":"Dawn Olsen","profile_url":"https://independent.academia.edu/DawnOlsen?f_ri=137516","photo":"/images/s65_no_pic.png"},{"id":47476740,"first_name":"Leonardo","last_name":"Aquiar-Lucas","domain_name":"independent","page_name":"LeonardoAquiarLucas","display_name":"Leonardo Aquiar-Lucas","profile_url":"https://independent.academia.edu/LeonardoAquiarLucas?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":25398,"name":"Vascular Surgery","url":"https://www.academia.edu/Documents/in/Vascular_Surgery?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":228722,"name":"Vascular","url":"https://www.academia.edu/Documents/in/Vascular?f_ri=137516","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=137516"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=137516"},{"id":715808,"name":"prosthesis Design","url":"https://www.academia.edu/Documents/in/prosthesis_Design?f_ri=137516"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13559571" data-work_id="13559571" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13559571/Oral_cleft_prevention_program_OCPP_">Oral cleft prevention program (OCPP)</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Oral clefts are one of the most common birth defects with significant medical, psychosocial, and economic ramifications. Oral clefts have a complex etiology with genetic and environmental risk factors. There are suggestive... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13559571" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Oral clefts are one of the most common birth defects with significant medical, psychosocial, and economic ramifications. Oral clefts have a complex etiology with genetic and environmental risk factors. There are suggestive results for decreased risks of cleft occurrence and recurrence with folic acid supplements taken at preconception and during pregnancy with a stronger evidence for higher than lower doses in preventing recurrence. Yet previous studies have suffered from considerable design limitations particularly non-randomization into treatment. There is also well-documented effectiveness for folic acid in preventing neural tube defect occurrence at 0.4 mg and recurrence with 4 mg. Given the substantial burden of clefting on the individual and the family and the supportive data for the effectiveness of folic acid supplementation as well as its low cost, a randomized clinical trial of the effectiveness of high versus low dose folic acid for prevention of cleft recurrence is warranted. Methods/design: This study will assess the effect of 4 mg and 0.4 mg doses of folic acid, taken on a daily basis during preconception and up to 3 months of pregnancy by women who are at risk of having a child with nonsyndromic cleft lip with/without palate (NSCL/P), on the recurrence of NSCL/P. The total sample will include about 6,000 women (that either have NSCL/P or that have at least one child with NSCL/P) randomly assigned to the 4 mg and the 0.4 mg folic acid study groups. The study will also compare the recurrence rates of NSCL/P in the total sample of subjects, as well as the two study groups (4mg, 0.4 mg) to that of a historical control group. The study has been approved by IRBs (ethics committees) of all involved sites. Results will be disseminated through publications and presentations at scientific meetings.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13559571" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f790ed734269b8b09f4f70cad8d139fe" rel="nofollow" data-download="{"attachment_id":45215838,"asset_id":13559571,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45215838/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32744830" href="https://independent.academia.edu/HrishikeshChakraborty">Hrishikesh Chakraborty</a><script data-card-contents-for-user="32744830" type="text/json">{"id":32744830,"first_name":"Hrishikesh","last_name":"Chakraborty","domain_name":"independent","page_name":"HrishikeshChakraborty","display_name":"Hrishikesh Chakraborty","profile_url":"https://independent.academia.edu/HrishikeshChakraborty?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13559571 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13559571"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13559571, container: ".js-paper-rank-work_13559571", }); });</script></li><li class="js-percentile-work_13559571 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13559571; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13559571"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13559571 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13559571"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13559571; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13559571]").text(description); $(".js-view-count-work_13559571").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13559571").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13559571"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">13</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2066" rel="nofollow" href="https://www.academia.edu/Documents/in/Research_Design">Research Design</a>, <script data-card-contents-for-ri="2066" type="text/json">{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9917" rel="nofollow" href="https://www.academia.edu/Documents/in/Cleft_Palate">Cleft Palate</a>, <script data-card-contents-for-ri="9917" type="text/json">{"id":9917,"name":"Cleft Palate","url":"https://www.academia.edu/Documents/in/Cleft_Palate?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="21408" rel="nofollow" href="https://www.academia.edu/Documents/in/Folic_acid">Folic acid</a>, <script data-card-contents-for-ri="21408" type="text/json">{"id":21408,"name":"Folic acid","url":"https://www.academia.edu/Documents/in/Folic_acid?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62550" rel="nofollow" href="https://www.academia.edu/Documents/in/Pregnancy">Pregnancy</a><script data-card-contents-for-ri="62550" type="text/json">{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13559571]'), work: {"id":13559571,"title":"Oral cleft prevention program (OCPP)","created_at":"2015-07-02T13:57:09.372-07:00","url":"https://www.academia.edu/13559571/Oral_cleft_prevention_program_OCPP_?f_ri=137516","dom_id":"work_13559571","summary":"Background: Oral clefts are one of the most common birth defects with significant medical, psychosocial, and economic ramifications. Oral clefts have a complex etiology with genetic and environmental risk factors. There are suggestive results for decreased risks of cleft occurrence and recurrence with folic acid supplements taken at preconception and during pregnancy with a stronger evidence for higher than lower doses in preventing recurrence. Yet previous studies have suffered from considerable design limitations particularly non-randomization into treatment. There is also well-documented effectiveness for folic acid in preventing neural tube defect occurrence at 0.4 mg and recurrence with 4 mg. Given the substantial burden of clefting on the individual and the family and the supportive data for the effectiveness of folic acid supplementation as well as its low cost, a randomized clinical trial of the effectiveness of high versus low dose folic acid for prevention of cleft recurrence is warranted. Methods/design: This study will assess the effect of 4 mg and 0.4 mg doses of folic acid, taken on a daily basis during preconception and up to 3 months of pregnancy by women who are at risk of having a child with nonsyndromic cleft lip with/without palate (NSCL/P), on the recurrence of NSCL/P. The total sample will include about 6,000 women (that either have NSCL/P or that have at least one child with NSCL/P) randomly assigned to the 4 mg and the 0.4 mg folic acid study groups. The study will also compare the recurrence rates of NSCL/P in the total sample of subjects, as well as the two study groups (4mg, 0.4 mg) to that of a historical control group. The study has been approved by IRBs (ethics committees) of all involved sites. Results will be disseminated through publications and presentations at scientific meetings.","downloadable_attachments":[{"id":45215838,"asset_id":13559571,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32744830,"first_name":"Hrishikesh","last_name":"Chakraborty","domain_name":"independent","page_name":"HrishikeshChakraborty","display_name":"Hrishikesh Chakraborty","profile_url":"https://independent.academia.edu/HrishikeshChakraborty?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=137516","nofollow":true},{"id":9917,"name":"Cleft Palate","url":"https://www.academia.edu/Documents/in/Cleft_Palate?f_ri=137516","nofollow":true},{"id":21408,"name":"Folic acid","url":"https://www.academia.edu/Documents/in/Folic_acid?f_ri=137516","nofollow":true},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":152562,"name":"Dietary Supplements","url":"https://www.academia.edu/Documents/in/Dietary_Supplements?f_ri=137516"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=137516"},{"id":477954,"name":"Cleft Lip","url":"https://www.academia.edu/Documents/in/Cleft_Lip?f_ri=137516"},{"id":710012,"name":"Preconception Care","url":"https://www.academia.edu/Documents/in/Preconception_Care?f_ri=137516"},{"id":945595,"name":"Pilot Projects","url":"https://www.academia.edu/Documents/in/Pilot_Projects?f_ri=137516"},{"id":1011136,"name":"Clinical Protocols","url":"https://www.academia.edu/Documents/in/Clinical_Protocols?f_ri=137516"},{"id":1246554,"name":"SECONDARY PREVENTION","url":"https://www.academia.edu/Documents/in/SECONDARY_PREVENTION?f_ri=137516"},{"id":1327745,"name":"Prenatal Care","url":"https://www.academia.edu/Documents/in/Prenatal_Care?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14850025" data-work_id="14850025" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14850025/Plasma_free_choline_betaine_and_cognitive_performance_the_Hordaland_Health_Study">Plasma free choline, betaine and cognitive performance: the Hordaland Health Study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Choline and betaine are nutrients involved in one-carbon metabolism. Choline is essential for neurodevelopment and brain function. We studied the associations between cognitive function and plasma concentrations of free choline and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14850025" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Choline and betaine are nutrients involved in one-carbon metabolism. Choline is essential for neurodevelopment and brain function. We studied the associations between cognitive function and plasma concentrations of free choline and betaine. In a cross-sectional study, 2195 subjects (55 % women), aged 70-74 years, underwent extensive cognitive testing including the Kendrick Object Learning Test (KOLT), Trail Making Test (part A, TMT-A), modified versions of the Digit Symbol Test (m-DST), Block Design (m-BD), Mini-Mental State Examination (m-MMSE) and Controlled Oral Word Association Test (COWAT). Compared with low concentrations, high choline (.8·4 mmol/l) was associated with better test scores in the TMT-A (56·0 v. 61·5, P¼ 0·004), m-DST (10·5 v. 9·8, P¼ 0·005) and m-MMSE (11·5 v. 11·4, P¼ 0·01). A generalised additive regression model showed a positive dose -response relationship between the m-MMSE and choline (P¼0·012 from a corresponding linear regression model). Betaine was associated with the KOLT, TMT-A and COWAT, but after adjustments for potential confounders, the associations lost significance. Risk ratios (RR) for poor test performance roughly tripled when low choline was combined with either low plasma vitamin B 12 (# 257 pmol/l) concentrations (RR KOLT ¼ 2·6, 95 % CI 1·1, 6·1; RR m-MMSE ¼ 2·7, 95 % CI 1·1, 6·6; RR COWAT ¼ 3·1, 95 % CI 1·4, 7·2) or high methylmalonic acid (MMA) ($3·95 mmol/l) concentrations (RR m-BD ¼ 2·8, 95 % CI 1·3, 6·1). Low betaine (# 31·1 mmol/l) combined with high MMA was associated with elevated RR on KOLT (RR KOLT ¼ 2·5, 95 % CI 1·0, 6·2). Low plasma free choline concentrations are associated with poor cognitive performance. There were significant interactions between low choline or betaine and low vitamin B 12 or high MMA on cognitive performance.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14850025" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ce19a58a96f7f6982d7f006aff741c89" rel="nofollow" data-download="{"attachment_id":43844826,"asset_id":14850025,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43844826/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33816925" href="https://uib.academia.edu/IngvarBjelland">Ingvar Bjelland</a><script data-card-contents-for-user="33816925" type="text/json">{"id":33816925,"first_name":"Ingvar","last_name":"Bjelland","domain_name":"uib","page_name":"IngvarBjelland","display_name":"Ingvar Bjelland","profile_url":"https://uib.academia.edu/IngvarBjelland?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14850025 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14850025"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14850025, container: ".js-paper-rank-work_14850025", }); 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$(".js-view-count[data-work-id=14850025]").text(description); $(".js-view-count-work_14850025").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14850025").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14850025"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">18</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="591" rel="nofollow" href="https://www.academia.edu/Documents/in/Nutrition_and_Dietetics">Nutrition and Dietetics</a>, <script data-card-contents-for-ri="591" type="text/json">{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6791" rel="nofollow" href="https://www.academia.edu/Documents/in/Aging">Aging</a>, <script data-card-contents-for-ri="6791" type="text/json">{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8971" rel="nofollow" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a>, <script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9478" rel="nofollow" href="https://www.academia.edu/Documents/in/Diet">Diet</a><script data-card-contents-for-ri="9478" type="text/json">{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14850025]'), work: {"id":14850025,"title":"Plasma free choline, betaine and cognitive performance: the Hordaland Health Study","created_at":"2015-08-11T07:03:32.069-07:00","url":"https://www.academia.edu/14850025/Plasma_free_choline_betaine_and_cognitive_performance_the_Hordaland_Health_Study?f_ri=137516","dom_id":"work_14850025","summary":"Choline and betaine are nutrients involved in one-carbon metabolism. Choline is essential for neurodevelopment and brain function. We studied the associations between cognitive function and plasma concentrations of free choline and betaine. In a cross-sectional study, 2195 subjects (55 % women), aged 70-74 years, underwent extensive cognitive testing including the Kendrick Object Learning Test (KOLT), Trail Making Test (part A, TMT-A), modified versions of the Digit Symbol Test (m-DST), Block Design (m-BD), Mini-Mental State Examination (m-MMSE) and Controlled Oral Word Association Test (COWAT). Compared with low concentrations, high choline (.8·4 mmol/l) was associated with better test scores in the TMT-A (56·0 v. 61·5, P¼ 0·004), m-DST (10·5 v. 9·8, P¼ 0·005) and m-MMSE (11·5 v. 11·4, P¼ 0·01). A generalised additive regression model showed a positive dose -response relationship between the m-MMSE and choline (P¼0·012 from a corresponding linear regression model). Betaine was associated with the KOLT, TMT-A and COWAT, but after adjustments for potential confounders, the associations lost significance. Risk ratios (RR) for poor test performance roughly tripled when low choline was combined with either low plasma vitamin B 12 (# 257 pmol/l) concentrations (RR KOLT ¼ 2·6, 95 % CI 1·1, 6·1; RR m-MMSE ¼ 2·7, 95 % CI 1·1, 6·6; RR COWAT ¼ 3·1, 95 % CI 1·4, 7·2) or high methylmalonic acid (MMA) ($3·95 mmol/l) concentrations (RR m-BD ¼ 2·8, 95 % CI 1·3, 6·1). Low betaine (# 31·1 mmol/l) combined with high MMA was associated with elevated RR on KOLT (RR KOLT ¼ 2·5, 95 % CI 1·0, 6·2). Low plasma free choline concentrations are associated with poor cognitive performance. There were significant interactions between low choline or betaine and low vitamin B 12 or high MMA on cognitive performance.","downloadable_attachments":[{"id":43844826,"asset_id":14850025,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33816925,"first_name":"Ingvar","last_name":"Bjelland","domain_name":"uib","page_name":"IngvarBjelland","display_name":"Ingvar Bjelland","profile_url":"https://uib.academia.edu/IngvarBjelland?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics?f_ri=137516","nofollow":true},{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=137516","nofollow":true},{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=137516","nofollow":true},{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=137516","nofollow":true},{"id":29980,"name":"Animal Production","url":"https://www.academia.edu/Documents/in/Animal_Production?f_ri=137516"},{"id":51645,"name":"Norway","url":"https://www.academia.edu/Documents/in/Norway?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=137516"},{"id":573653,"name":"Food Sciences","url":"https://www.academia.edu/Documents/in/Food_Sciences?f_ri=137516"},{"id":584602,"name":"Geriatric Assessment","url":"https://www.academia.edu/Documents/in/Geriatric_Assessment?f_ri=137516"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=137516"},{"id":990296,"name":"Choline","url":"https://www.academia.edu/Documents/in/Choline?f_ri=137516"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=137516"},{"id":1716295,"name":"vitamin B deficiency","url":"https://www.academia.edu/Documents/in/vitamin_B_deficiency?f_ri=137516"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=137516"},{"id":2190576,"name":"Betaine","url":"https://www.academia.edu/Documents/in/Betaine?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_23776695" data-work_id="23776695" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/23776695/Microstructural_and_Functional_Connectivity_in_the_Developing_Preterm_Brain">Microstructural and Functional Connectivity in the Developing Preterm Brain</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Prematurely born children are at increased risk for cognitive deficits, but the neurobiological basis of these findings remains poorly understood. Since variations in neural circuitry may influence performance on cognitive tasks, recent... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_23776695" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Prematurely born children are at increased risk for cognitive deficits, but the neurobiological basis of these findings remains poorly understood. Since variations in neural circuitry may influence performance on cognitive tasks, recent investigations have explored the impact of preterm birth on connectivity in the developing brain. Diffusion tensor imaging studies demonstrate widespread alterations in fractional anisotropy, a measure of axonal integrity and microstructural connectivity, throughout the developing preterm brain. Functional connectivity studies report that preterm neonates, children and adolescents exhibit alterations in both resting state and task-based connectivity when compared to term control subjects. Taken together, these data suggest that neurodevelopmental impairment following preterm birth may represent a disease of neural connectivity.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23776695" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="740bb10b69634cf617aefe808115d834" rel="nofollow" data-download="{"attachment_id":44214518,"asset_id":23776695,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44214518/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5659270" href="https://yale.academia.edu/ToddConstable">Todd Constable</a><script data-card-contents-for-user="5659270" type="text/json">{"id":5659270,"first_name":"Todd","last_name":"Constable","domain_name":"yale","page_name":"ToddConstable","display_name":"Todd Constable","profile_url":"https://yale.academia.edu/ToddConstable?f_ri=137516","photo":"https://0.academia-photos.com/5659270/2460785/2860022/s65_todd.constable.png"}</script></span></span></li><li class="js-paper-rank-work_23776695 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23776695"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23776695, container: ".js-paper-rank-work_23776695", }); 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$(".js-view-count[data-work-id=23776695]").text(description); $(".js-view-count-work_23776695").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_23776695").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="23776695"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">14</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52763" rel="nofollow" href="https://www.academia.edu/Documents/in/Functional_Connectivity">Functional Connectivity</a>, <script data-card-contents-for-ri="52763" type="text/json">{"id":52763,"name":"Functional Connectivity","url":"https://www.academia.edu/Documents/in/Functional_Connectivity?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="61474" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain">Brain</a>, <script data-card-contents-for-ri="61474" type="text/json">{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a><script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23776695]'), work: {"id":23776695,"title":"Microstructural and Functional Connectivity in the Developing Preterm Brain","created_at":"2016-03-29T17:37:09.563-07:00","url":"https://www.academia.edu/23776695/Microstructural_and_Functional_Connectivity_in_the_Developing_Preterm_Brain?f_ri=137516","dom_id":"work_23776695","summary":"Prematurely born children are at increased risk for cognitive deficits, but the neurobiological basis of these findings remains poorly understood. Since variations in neural circuitry may influence performance on cognitive tasks, recent investigations have explored the impact of preterm birth on connectivity in the developing brain. Diffusion tensor imaging studies demonstrate widespread alterations in fractional anisotropy, a measure of axonal integrity and microstructural connectivity, throughout the developing preterm brain. Functional connectivity studies report that preterm neonates, children and adolescents exhibit alterations in both resting state and task-based connectivity when compared to term control subjects. Taken together, these data suggest that neurodevelopmental impairment following preterm birth may represent a disease of neural connectivity.","downloadable_attachments":[{"id":44214518,"asset_id":23776695,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5659270,"first_name":"Todd","last_name":"Constable","domain_name":"yale","page_name":"ToddConstable","display_name":"Todd Constable","profile_url":"https://yale.academia.edu/ToddConstable?f_ri=137516","photo":"https://0.academia-photos.com/5659270/2460785/2860022/s65_todd.constable.png"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=137516","nofollow":true},{"id":52763,"name":"Functional Connectivity","url":"https://www.academia.edu/Documents/in/Functional_Connectivity?f_ri=137516","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=137516"},{"id":341842,"name":"Seminars","url":"https://www.academia.edu/Documents/in/Seminars?f_ri=137516"},{"id":473797,"name":"Microstructures","url":"https://www.academia.edu/Documents/in/Microstructures?f_ri=137516"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=137516"},{"id":1287048,"name":"Interneurons","url":"https://www.academia.edu/Documents/in/Interneurons?f_ri=137516"},{"id":1399301,"name":"Premature Birth","url":"https://www.academia.edu/Documents/in/Premature_Birth?f_ri=137516"},{"id":1627527,"name":"Cognition disorders","url":"https://www.academia.edu/Documents/in/Cognition_disorders?f_ri=137516"},{"id":1765793,"name":"Brain Diseases","url":"https://www.academia.edu/Documents/in/Brain_Diseases?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_30768911" data-work_id="30768911" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30768911/Transpapillary_and_transmural_drainage_of_pancreatic_pseudocysts">Transpapillary and transmural drainage of pancreatic pseudocysts</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Pancreatic pseudocyst endoscopic drainage has been described as a good treatment option, with morbidity and mortality rates that are lower than surgery. The aim of our study is to describe the efficacy of different forms of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_30768911" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Pancreatic pseudocyst endoscopic drainage has been described as a good treatment option, with morbidity and mortality rates that are lower than surgery. The aim of our study is to describe the efficacy of different forms of endoscopic drainage and estimate pseudocyst recurrence rate after short follow up period.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30768911" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fdad6d15381fc7d5e63c45aa83d792f9" rel="nofollow" data-download="{"attachment_id":51205215,"asset_id":30768911,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51205215/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="58576642" href="https://independent.academia.edu/HansSeifert1">Hans Seifert</a><script data-card-contents-for-user="58576642" type="text/json">{"id":58576642,"first_name":"Hans","last_name":"Seifert","domain_name":"independent","page_name":"HansSeifert1","display_name":"Hans Seifert","profile_url":"https://independent.academia.edu/HansSeifert1?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_30768911 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30768911"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30768911, container: ".js-paper-rank-work_30768911", }); 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$(".js-view-count[data-work-id=30768911]").text(description); $(".js-view-count-work_30768911").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_30768911").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="30768911"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">13</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="27521" rel="nofollow" href="https://www.academia.edu/Documents/in/Stents">Stents</a>, <script data-card-contents-for-ri="27521" type="text/json">{"id":27521,"name":"Stents","url":"https://www.academia.edu/Documents/in/Stents?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a><script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=30768911]'), work: {"id":30768911,"title":"Transpapillary and transmural drainage of pancreatic pseudocysts","created_at":"2017-01-05T08:15:07.148-08:00","url":"https://www.academia.edu/30768911/Transpapillary_and_transmural_drainage_of_pancreatic_pseudocysts?f_ri=137516","dom_id":"work_30768911","summary":"Background: Pancreatic pseudocyst endoscopic drainage has been described as a good treatment option, with morbidity and mortality rates that are lower than surgery. The aim of our study is to describe the efficacy of different forms of endoscopic drainage and estimate pseudocyst recurrence rate after short follow up period.","downloadable_attachments":[{"id":51205215,"asset_id":30768911,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":58576642,"first_name":"Hans","last_name":"Seifert","domain_name":"independent","page_name":"HansSeifert1","display_name":"Hans Seifert","profile_url":"https://independent.academia.edu/HansSeifert1?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=137516","nofollow":true},{"id":27521,"name":"Stents","url":"https://www.academia.edu/Documents/in/Stents?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":218617,"name":"Chronic Pancreatitis","url":"https://www.academia.edu/Documents/in/Chronic_Pancreatitis?f_ri=137516"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":343756,"name":"Gastrointestinal Endoscopy","url":"https://www.academia.edu/Documents/in/Gastrointestinal_Endoscopy?f_ri=137516"},{"id":401586,"name":"Gastrointestinal","url":"https://www.academia.edu/Documents/in/Gastrointestinal?f_ri=137516"},{"id":424621,"name":"Drainage","url":"https://www.academia.edu/Documents/in/Drainage?f_ri=137516"},{"id":493102,"name":"Conservation Management","url":"https://www.academia.edu/Documents/in/Conservation_Management?f_ri=137516"},{"id":869579,"name":"Gastrostomy","url":"https://www.academia.edu/Documents/in/Gastrostomy?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_52389479" data-work_id="52389479" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/52389479/Variable_long_term_outcomes_from_cochlear_implantation_in_children_with_hypoplastic_auditory_nerves">Variable long-term outcomes from cochlear implantation in children with hypoplastic auditory nerves</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">This paper describes the outcomes in six children with hypoplastic cochlear nerves, demonstrated on magnetic resonance imaging who were selected for implantation because they had clear responses to sound, with hearing aids. In four of the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_52389479" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This paper describes the outcomes in six children with hypoplastic cochlear nerves, demonstrated on magnetic resonance imaging who were selected for implantation because they had clear responses to sound, with hearing aids. In four of the six children the internal auditory canals were abnormally narrow; however in the remaining two the internal auditory canals were of normal width. After activation of their devices, all six children had auditory thresholds within the normal range for implanted congenitally deaf children. However the progress of all these children after 2 to 6 years of implant use turned out to be disappointing. Five of the children developed only the ability to detect the presence of sound, and were unable to discriminate accurately between speech sounds. They remain at Category of Auditory Performance (CAP) level 2: sign is their primary mode of communication. All fi ve children also remain at Speech Intelligibility Rating (SIR) level 2, with unintelligible connected speech. The sixth child was able to develop some understanding of common phrases through listening alone, however he remains at CAP level 4 and his SIR level also remains at 2. The benefi t of cochlear implantation in this group of children is likely to be considerably restricted. In specifi c cases it may be appropriate to offer a cochlear implant to a child with hypoplastic auditory nerves but careful counselling of the family about likely outcomes is essential.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/52389479" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3851e1d9dccd09f1ada102f58271a44f" rel="nofollow" data-download="{"attachment_id":69675721,"asset_id":52389479,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/69675721/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="161291500" href="https://independent.academia.edu/JohnGraham96">John Graham</a><script data-card-contents-for-user="161291500" type="text/json">{"id":161291500,"first_name":"John","last_name":"Graham","domain_name":"independent","page_name":"JohnGraham96","display_name":"John Graham","profile_url":"https://independent.academia.edu/JohnGraham96?f_ri=137516","photo":"https://0.academia-photos.com/161291500/45236263/35342884/s65_john.graham.jpg"}</script></span></span></li><li class="js-paper-rank-work_52389479 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="52389479"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 52389479, container: ".js-paper-rank-work_52389479", }); });</script></li><li class="js-percentile-work_52389479 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52389479; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_52389479"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_52389479 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="52389479"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52389479; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52389479]").text(description); $(".js-view-count-work_52389479").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_52389479").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="52389479"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">14</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1214" rel="nofollow" href="https://www.academia.edu/Documents/in/Sign_Language">Sign Language</a>, <script data-card-contents-for-ri="1214" type="text/json">{"id":1214,"name":"Sign Language","url":"https://www.academia.edu/Documents/in/Sign_Language?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="5391" rel="nofollow" href="https://www.academia.edu/Documents/in/Speech_perception">Speech perception</a>, <script data-card-contents-for-ri="5391" type="text/json">{"id":5391,"name":"Speech perception","url":"https://www.academia.edu/Documents/in/Speech_perception?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="76622" rel="nofollow" href="https://www.academia.edu/Documents/in/Cochlear_Implant">Cochlear Implant</a><script data-card-contents-for-ri="76622" type="text/json">{"id":76622,"name":"Cochlear Implant","url":"https://www.academia.edu/Documents/in/Cochlear_Implant?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=52389479]'), work: {"id":52389479,"title":"Variable long-term outcomes from cochlear implantation in children with hypoplastic auditory nerves","created_at":"2021-09-14T22:54:03.750-07:00","url":"https://www.academia.edu/52389479/Variable_long_term_outcomes_from_cochlear_implantation_in_children_with_hypoplastic_auditory_nerves?f_ri=137516","dom_id":"work_52389479","summary":"This paper describes the outcomes in six children with hypoplastic cochlear nerves, demonstrated on magnetic resonance imaging who were selected for implantation because they had clear responses to sound, with hearing aids. In four of the six children the internal auditory canals were abnormally narrow; however in the remaining two the internal auditory canals were of normal width. After activation of their devices, all six children had auditory thresholds within the normal range for implanted congenitally deaf children. However the progress of all these children after 2 to 6 years of implant use turned out to be disappointing. Five of the children developed only the ability to detect the presence of sound, and were unable to discriminate accurately between speech sounds. They remain at Category of Auditory Performance (CAP) level 2: sign is their primary mode of communication. All fi ve children also remain at Speech Intelligibility Rating (SIR) level 2, with unintelligible connected speech. The sixth child was able to develop some understanding of common phrases through listening alone, however he remains at CAP level 4 and his SIR level also remains at 2. The benefi t of cochlear implantation in this group of children is likely to be considerably restricted. In specifi c cases it may be appropriate to offer a cochlear implant to a child with hypoplastic auditory nerves but careful counselling of the family about likely outcomes is essential.","downloadable_attachments":[{"id":69675721,"asset_id":52389479,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":161291500,"first_name":"John","last_name":"Graham","domain_name":"independent","page_name":"JohnGraham96","display_name":"John Graham","profile_url":"https://independent.academia.edu/JohnGraham96?f_ri=137516","photo":"https://0.academia-photos.com/161291500/45236263/35342884/s65_john.graham.jpg"}],"research_interests":[{"id":1214,"name":"Sign Language","url":"https://www.academia.edu/Documents/in/Sign_Language?f_ri=137516","nofollow":true},{"id":5391,"name":"Speech perception","url":"https://www.academia.edu/Documents/in/Speech_perception?f_ri=137516","nofollow":true},{"id":6200,"name":"Magnetic Resonance 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Cholecalciferol Repletion in Hemodialysis: Results From the VitaDial Randomized Trial</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21691463" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c2e44bfdda1715b4066e034f26881fb0" rel="nofollow" data-download="{"attachment_id":42387199,"asset_id":21691463,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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years</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/32963430" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fb28d0220af5587deb9bd5cdfc94e4aa" rel="nofollow" data-download="{"attachment_id":53088849,"asset_id":32963430,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/53088849/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i 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})();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13328628" data-work_id="13328628" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13328628/Transitional_Care_of_Older_Adults_Hospitalized_with_Heart_Failure_A_Randomized_Controlled_Trial">Transitional Care of Older Adults Hospitalized with Heart Failure: A Randomized, Controlled Trial</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">OBJECTIVES: To examine the effectiveness of a transitional care intervention delivered by advanced practice nurses (APNs) to elders hospitalized with heart failure. DESIGN: Randomized, controlled trial with follow-up through 52 weeks... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13328628" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">OBJECTIVES: To examine the effectiveness of a transitional care intervention delivered by advanced practice nurses (APNs) to elders hospitalized with heart failure. DESIGN: Randomized, controlled trial with follow-up through 52 weeks postindex hospital discharge. SETTING: Six Philadelphia academic and community hospitals. PARTICIPANTS: Two hundred thirty-nine eligible patients were aged 65 and older and hospitalized with heart failure. INTERVENTION: A 3-month APN-directed discharge planning and home follow-up protocol. MEASUREMENTS: Time to first rehospitalization or death, number of rehospitalizations, quality of life, functional status, costs, and satisfaction with care. RESULTS: Mean age of patients (control n 5 121; intervention n 5 118) enrolled was 76; 43% were male, and 36% were African American. Time to first readmission or death was longer in intervention patients (log rank w 2 5 5.0, P 5.026; Cox regression incidence density ratio 5 1.65, 95% confidence interval 5 1.13-2.40). At 52 weeks, intervention group patients had fewer readmissions (104 vs 162, P 5.047) and lower mean total costs ($7,636 vs $12,481, P 5.002). For intervention patients, only short-term improvements were demonstrated in overall quality of life (12 weeks, Po.05), physical dimension of quality of life (2 weeks, Po.01; 12 weeks, Po.05) and patient satisfaction (assessed at 2 and 6 weeks, Po.001).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13328628" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="150d3c8f2b6caeb2f0edffe015d50dbe" rel="nofollow" data-download="{"attachment_id":45460915,"asset_id":13328628,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45460915/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32570289" href="https://upenn.academia.edu/GregMaislin">Greg Maislin</a><script data-card-contents-for-user="32570289" type="text/json">{"id":32570289,"first_name":"Greg","last_name":"Maislin","domain_name":"upenn","page_name":"GregMaislin","display_name":"Greg Maislin","profile_url":"https://upenn.academia.edu/GregMaislin?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13328628 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13328628"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13328628, container: ".js-paper-rank-work_13328628", }); 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DESIGN: Randomized, controlled trial with follow-up through 52 weeks postindex hospital discharge. SETTING: Six Philadelphia academic and community hospitals. PARTICIPANTS: Two hundred thirty-nine eligible patients were aged 65 and older and hospitalized with heart failure. INTERVENTION: A 3-month APN-directed discharge planning and home follow-up protocol. MEASUREMENTS: Time to first rehospitalization or death, number of rehospitalizations, quality of life, functional status, costs, and satisfaction with care. RESULTS: Mean age of patients (control n 5 121; intervention n 5 118) enrolled was 76; 43% were male, and 36% were African American. Time to first readmission or death was longer in intervention patients (log rank w 2 5 5.0, P 5.026; Cox regression incidence density ratio 5 1.65, 95% confidence interval 5 1.13-2.40). At 52 weeks, intervention group patients had fewer readmissions (104 vs 162, P 5.047) and lower mean total costs ($7,636 vs $12,481, P 5.002). For intervention patients, only short-term improvements were demonstrated in overall quality of life (12 weeks, Po.05), physical dimension of quality of life (2 weeks, Po.01; 12 weeks, Po.05) and patient satisfaction (assessed at 2 and 6 weeks, Po.001).","downloadable_attachments":[{"id":45460915,"asset_id":13328628,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32570289,"first_name":"Greg","last_name":"Maislin","domain_name":"upenn","page_name":"GregMaislin","display_name":"Greg Maislin","profile_url":"https://upenn.academia.edu/GregMaislin?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=137516","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=137516","nofollow":true},{"id":68342,"name":"African American","url":"https://www.academia.edu/Documents/in/African_American?f_ri=137516"},{"id":75348,"name":"Cox Regression","url":"https://www.academia.edu/Documents/in/Cox_Regression?f_ri=137516"},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization?f_ri=137516"},{"id":123230,"name":"Regression Analysis","url":"https://www.academia.edu/Documents/in/Regression_Analysis?f_ri=137516"},{"id":129744,"name":"Confidence intervals","url":"https://www.academia.edu/Documents/in/Confidence_intervals?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":144052,"name":"Patient Satisfaction","url":"https://www.academia.edu/Documents/in/Patient_Satisfaction?f_ri=137516"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The?f_ri=137516"},{"id":194055,"name":"Randomised Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomised_Controlled_Trial?f_ri=137516"},{"id":233800,"name":"African Americans","url":"https://www.academia.edu/Documents/in/African_Americans?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":408219,"name":"Aftercare","url":"https://www.academia.edu/Documents/in/Aftercare?f_ri=137516"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=137516"},{"id":413196,"name":"Randomized Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomized_Controlled_Trial?f_ri=137516"},{"id":561981,"name":"European Continental Ancestry Group","url":"https://www.academia.edu/Documents/in/European_Continental_Ancestry_Group?f_ri=137516"},{"id":719793,"name":"Healthcare Costs","url":"https://www.academia.edu/Documents/in/Healthcare_Costs?f_ri=137516"},{"id":806178,"name":"Older Adult","url":"https://www.academia.edu/Documents/in/Older_Adult?f_ri=137516"},{"id":1034177,"name":"Continuity of Patient Care","url":"https://www.academia.edu/Documents/in/Continuity_of_Patient_Care?f_ri=137516"},{"id":1441309,"name":"Functional Status","url":"https://www.academia.edu/Documents/in/Functional_Status?f_ri=137516"},{"id":1524625,"name":"Home Care Services","url":"https://www.academia.edu/Documents/in/Home_Care_Services?f_ri=137516"},{"id":1587858,"name":"Confidence Interval","url":"https://www.academia.edu/Documents/in/Confidence_Interval?f_ri=137516"},{"id":2345130,"name":"Socioeconomic Factors","url":"https://www.academia.edu/Documents/in/Socioeconomic_Factors?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14922918" data-work_id="14922918" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14922918/Improving_follow_up_to_abnormal_breast_cancer_screening_in_an_urban_population">Improving follow-up to abnormal breast cancer screening in an urban population</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Delays in follow-up after cancer screening contribute to racial/ethnic disparities in cancer outcomes. We evaluated a patient navigator intervention among innercity women with breast abnormalities. A full-time patient navigator supported... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14922918" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Delays in follow-up after cancer screening contribute to racial/ethnic disparities in cancer outcomes. We evaluated a patient navigator intervention among innercity women with breast abnormalities. A full-time patient navigator supported patients using the care management model. Female patients 18 years and above, referred to an urban, hospital-based, diagnostic breast health practice from January to June 2000 (preintervention) and November 2001 to February 2003 (intervention), were studied. Timely follow-up was defined as arrival to diagnostic evaluation within 120 days from the date the original appointment was scheduled. Data were collected via computerized registration, medical records, and patient interview. Bivariate and multivariate logistic regression analyses were conducted, comparing preintervention and intervention groups, with propensity score analysis and time trend analysis to address the limitations of the pre-post design. 314 patients were scheduled preintervention; 1018, during the intervention. Overall, mean age was 44 years; 40% black, 36% non-Hispanic white, 14%</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14922918" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8f2656b345ea9a0a9f0dee245d08c8a5" rel="nofollow" data-download="{"attachment_id":43768344,"asset_id":14922918,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43768344/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33911228" href="https://bu.academia.edu/TracyBattaglia">Tracy Battaglia</a><script data-card-contents-for-user="33911228" type="text/json">{"id":33911228,"first_name":"Tracy","last_name":"Battaglia","domain_name":"bu","page_name":"TracyBattaglia","display_name":"Tracy Battaglia","profile_url":"https://bu.academia.edu/TracyBattaglia?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14922918 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14922918"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14922918, container: ".js-paper-rank-work_14922918", }); 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We evaluated a patient navigator intervention among innercity women with breast abnormalities. A full-time patient navigator supported patients using the care management model. Female patients 18 years and above, referred to an urban, hospital-based, diagnostic breast health practice from January to June 2000 (preintervention) and November 2001 to February 2003 (intervention), were studied. Timely follow-up was defined as arrival to diagnostic evaluation within 120 days from the date the original appointment was scheduled. Data were collected via computerized registration, medical records, and patient interview. Bivariate and multivariate logistic regression analyses were conducted, comparing preintervention and intervention groups, with propensity score analysis and time trend analysis to address the limitations of the pre-post design. 314 patients were scheduled preintervention; 1018, during the intervention. Overall, mean age was 44 years; 40% black, 36% non-Hispanic white, 14%","downloadable_attachments":[{"id":43768344,"asset_id":14922918,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33911228,"first_name":"Tracy","last_name":"Battaglia","domain_name":"bu","page_name":"TracyBattaglia","display_name":"Tracy Battaglia","profile_url":"https://bu.academia.edu/TracyBattaglia?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=137516","nofollow":true},{"id":16765,"name":"Cancer Prevention","url":"https://www.academia.edu/Documents/in/Cancer_Prevention?f_ri=137516","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=137516","nofollow":true},{"id":70596,"name":"Minority Groups","url":"https://www.academia.edu/Documents/in/Minority_Groups?f_ri=137516","nofollow":true},{"id":98134,"name":"United 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Intrabony Defects</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/33215793" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4451bc57164e61351e68b0cc038fa1a7" rel="nofollow" data-download="{"attachment_id":53293937,"asset_id":33215793,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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type="text/json">{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="38237" rel="nofollow" href="https://www.academia.edu/Documents/in/Bone_Regeneration">Bone Regeneration</a>, <script data-card-contents-for-ri="38237" type="text/json">{"id":38237,"name":"Bone Regeneration","url":"https://www.academia.edu/Documents/in/Bone_Regeneration?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="50515" rel="nofollow" href="https://www.academia.edu/Documents/in/Periodontology">Periodontology</a><script data-card-contents-for-ri="50515" type="text/json">{"id":50515,"name":"Periodontology","url":"https://www.academia.edu/Documents/in/Periodontology?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=33215793]'), work: {"id":33215793,"title":"Clinical Effectiveness of Autologous Platelet-Rich Plasma and Peptide-Enhanced Bone Graft in the Treatment of Intrabony 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Pai","profile_url":"https://sjic.academia.edu/SujathaPai?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":38237,"name":"Bone Regeneration","url":"https://www.academia.edu/Documents/in/Bone_Regeneration?f_ri=137516","nofollow":true},{"id":50515,"name":"Periodontology","url":"https://www.academia.edu/Documents/in/Periodontology?f_ri=137516","nofollow":true},{"id":61111,"name":"Bone graft","url":"https://www.academia.edu/Documents/in/Bone_graft?f_ri=137516"},{"id":79808,"name":"Collagen","url":"https://www.academia.edu/Documents/in/Collagen?f_ri=137516"},{"id":123287,"name":"Three Dimensional Imaging","url":"https://www.academia.edu/Documents/in/Three_Dimensional_Imaging?f_ri=137516"},{"id":133057,"name":"Young 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itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/23281770/Emerging_markers_of_cachexia_predict_survival_in_cancer_patients">Emerging markers of cachexia predict survival in cancer patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic and predictive... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_23281770" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic and predictive markers of cachexia in oncologic patients. Their impact on patient survival was also evaluated. Methods: 140 adults with different cancer diagnoses were recruited. Thirty healthy volunteers served as control. Serum ghrelin, obestatin and leptin were tested at baseline and after a follow-up period of 18 months. Results: Ghrelin levels were significantly higher in cancer patients than in healthy subjects (573.31 ± 130 vs 320.20 ± 66.48 ng/ml, p < 0.0001), while obestatin (17.42 ± 7.12 vs 24.89 ± 5.54 ng/ml, p < 0.0001) and leptin (38.4 ± 21.2 vs 76.28 ± 17.48 ng/ml, p < 0.0001) values were lower. At ROC analyses the diagnostic profile of ghrelin (AUC 0.962; sensitivity 83%; specificity 98%), obestatin (AUC 0.798; sensitivity 74.5%; specificity 81.5%) and leptin (AUC 0.828; sensitivity 79%; specificity 73%) was superior to that of albumin (AUC 0.547; sensitivity 63%, specificity 69.4%) for detecting cachexia among cancer patients. On Cox multivariate analyses ghrelin (HR 1.02; 95% CI 1.01 -1.03; p < 0.0001) and leptin (HR 0.94; 95% CI 0.92 -0.96; p < 0.0001) were significant predictors of death even after correction for other known risk factors such as presence of metastasis and chronic kidney disease. Conclusion: Ghrelin and leptin are promising biomarkers to diagnose cachexia and to predict survival in cancer patients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23281770" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e03d122bbab92b45c069a9c8db7c0919" rel="nofollow" data-download="{"attachment_id":43751435,"asset_id":23281770,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43751435/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="45162731" href="https://unime.academia.edu/SMondello">Stefania Mondello</a><script data-card-contents-for-user="45162731" type="text/json">{"id":45162731,"first_name":"Stefania","last_name":"Mondello","domain_name":"unime","page_name":"SMondello","display_name":"Stefania Mondello","profile_url":"https://unime.academia.edu/SMondello?f_ri=137516","photo":"https://0.academia-photos.com/45162731/28977264/27032638/s65_stefania.mondello.jpg"}</script></span></span></li><li class="js-paper-rank-work_23281770 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23281770"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23281770, container: ".js-paper-rank-work_23281770", }); 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$(".js-view-count[data-work-id=23281770]").text(description); $(".js-view-count-work_23281770").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_23281770").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="23281770"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">18</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="41783" rel="nofollow" href="https://www.academia.edu/Documents/in/Ghrelin">Ghrelin</a>, <script data-card-contents-for-ri="41783" type="text/json">{"id":41783,"name":"Ghrelin","url":"https://www.academia.edu/Documents/in/Ghrelin?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="71511" rel="nofollow" href="https://www.academia.edu/Documents/in/Diabetes_mellitus">Diabetes mellitus</a>, <script data-card-contents-for-ri="71511" type="text/json">{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="90514" rel="nofollow" href="https://www.academia.edu/Documents/in/Cholesterol">Cholesterol</a><script data-card-contents-for-ri="90514" type="text/json">{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23281770]'), work: {"id":23281770,"title":"Emerging markers of cachexia predict survival in cancer patients","created_at":"2016-03-15T08:26:18.887-07:00","url":"https://www.academia.edu/23281770/Emerging_markers_of_cachexia_predict_survival_in_cancer_patients?f_ri=137516","dom_id":"work_23281770","summary":"Background: Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic and predictive markers of cachexia in oncologic patients. Their impact on patient survival was also evaluated. Methods: 140 adults with different cancer diagnoses were recruited. Thirty healthy volunteers served as control. Serum ghrelin, obestatin and leptin were tested at baseline and after a follow-up period of 18 months. Results: Ghrelin levels were significantly higher in cancer patients than in healthy subjects (573.31 ± 130 vs 320.20 ± 66.48 ng/ml, p \u003c 0.0001), while obestatin (17.42 ± 7.12 vs 24.89 ± 5.54 ng/ml, p \u003c 0.0001) and leptin (38.4 ± 21.2 vs 76.28 ± 17.48 ng/ml, p \u003c 0.0001) values were lower. At ROC analyses the diagnostic profile of ghrelin (AUC 0.962; sensitivity 83%; specificity 98%), obestatin (AUC 0.798; sensitivity 74.5%; specificity 81.5%) and leptin (AUC 0.828; sensitivity 79%; specificity 73%) was superior to that of albumin (AUC 0.547; sensitivity 63%, specificity 69.4%) for detecting cachexia among cancer patients. On Cox multivariate analyses ghrelin (HR 1.02; 95% CI 1.01 -1.03; p \u003c 0.0001) and leptin (HR 0.94; 95% CI 0.92 -0.96; p \u003c 0.0001) were significant predictors of death even after correction for other known risk factors such as presence of metastasis and chronic kidney disease. Conclusion: Ghrelin and leptin are promising biomarkers to diagnose cachexia and to predict survival in cancer patients.","downloadable_attachments":[{"id":43751435,"asset_id":23281770,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":45162731,"first_name":"Stefania","last_name":"Mondello","domain_name":"unime","page_name":"SMondello","display_name":"Stefania Mondello","profile_url":"https://unime.academia.edu/SMondello?f_ri=137516","photo":"https://0.academia-photos.com/45162731/28977264/27032638/s65_stefania.mondello.jpg"}],"research_interests":[{"id":41783,"name":"Ghrelin","url":"https://www.academia.edu/Documents/in/Ghrelin?f_ri=137516","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=137516","nofollow":true},{"id":71511,"name":"Diabetes 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data-work_id="22353616" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22353616/B%C3%A9n%C3%A9fice_d_un_programme_cognitivo_comportemental_et_pluridisciplinaire_de_prise_en_charge_de_la_maladie_d_Alzheimer_sur_l_anxi%C3%A9t%C3%A9_du_conjoint_%C3%A9tude_fran%C3%A7aise_ELMMA">Bénéfice d’un programme cognitivo-comportemental et pluridisciplinaire de prise en charge de la maladie d’Alzheimer sur l’anxiété du conjoint : étude française ELMMA</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Bé né fice d'un programme cognitivo-comportemental et pluridisciplinaire de prise en charge de la maladie d'Alzheimer sur l'anxié té du conjoint : é tude française ELMMA Beneficial effect of a cognitive behavioral and multidisciplinary... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22353616" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Bé né fice d'un programme cognitivo-comportemental et pluridisciplinaire de prise en charge de la maladie d'Alzheimer sur l'anxié té du conjoint : é tude française ELMMA Beneficial effect of a cognitive behavioral and multidisciplinary program in Alzheimer Disease on spouse caregiver anxiety: French study ELMMA</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22353616" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1320e9039b81dbb9a9794d18b619fe8e" rel="nofollow" data-download="{"attachment_id":42982854,"asset_id":22353616,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42982854/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43331331" href="https://univ-paris5.academia.edu/CatherineBungener">Catherine Bungener</a><script data-card-contents-for-user="43331331" type="text/json">{"id":43331331,"first_name":"Catherine","last_name":"Bungener","domain_name":"univ-paris5","page_name":"CatherineBungener","display_name":"Catherine Bungener","profile_url":"https://univ-paris5.academia.edu/CatherineBungener?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22353616 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22353616"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22353616, container: ".js-paper-rank-work_22353616", }); });</script></li><li class="js-percentile-work_22353616 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x 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type="text/json">{"id":27336,"name":"France","url":"https://www.academia.edu/Documents/in/France?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="38676" rel="nofollow" href="https://www.academia.edu/Documents/in/Anxiety">Anxiety</a>, <script data-card-contents-for-ri="38676" type="text/json">{"id":38676,"name":"Anxiety","url":"https://www.academia.edu/Documents/in/Anxiety?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="101797" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Therapy">Cognitive Therapy</a><script data-card-contents-for-ri="101797" type="text/json">{"id":101797,"name":"Cognitive Therapy","url":"https://www.academia.edu/Documents/in/Cognitive_Therapy?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22353616]'), work: {"id":22353616,"title":"Bénéfice d’un programme cognitivo-comportemental et pluridisciplinaire de prise en charge de la maladie d’Alzheimer sur l’anxiété du conjoint : étude française ELMMA","created_at":"2016-02-23T09:30:49.192-08:00","url":"https://www.academia.edu/22353616/B%C3%A9n%C3%A9fice_d_un_programme_cognitivo_comportemental_et_pluridisciplinaire_de_prise_en_charge_de_la_maladie_d_Alzheimer_sur_l_anxi%C3%A9t%C3%A9_du_conjoint_%C3%A9tude_fran%C3%A7aise_ELMMA?f_ri=137516","dom_id":"work_22353616","summary":"Bé né fice d'un programme cognitivo-comportemental et pluridisciplinaire de prise en charge de la maladie d'Alzheimer sur l'anxié té du conjoint : é tude française ELMMA Beneficial effect of a cognitive behavioral and multidisciplinary program in Alzheimer Disease on spouse caregiver anxiety: French study ELMMA","downloadable_attachments":[{"id":42982854,"asset_id":22353616,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43331331,"first_name":"Catherine","last_name":"Bungener","domain_name":"univ-paris5","page_name":"CatherineBungener","display_name":"Catherine Bungener","profile_url":"https://univ-paris5.academia.edu/CatherineBungener?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=137516","nofollow":true},{"id":27336,"name":"France","url":"https://www.academia.edu/Documents/in/France?f_ri=137516","nofollow":true},{"id":38676,"name":"Anxiety","url":"https://www.academia.edu/Documents/in/Anxiety?f_ri=137516","nofollow":true},{"id":101797,"name":"Cognitive Therapy","url":"https://www.academia.edu/Documents/in/Cognitive_Therapy?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":157943,"name":"Depressive Disorder","url":"https://www.academia.edu/Documents/in/Depressive_Disorder?f_ri=137516"},{"id":201441,"name":"Caregivers","url":"https://www.academia.edu/Documents/in/Caregivers?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":395473,"name":"Patient Care Team","url":"https://www.academia.edu/Documents/in/Patient_Care_Team?f_ri=137516"},{"id":606036,"name":"Psychotropic Drugs","url":"https://www.academia.edu/Documents/in/Psychotropic_Drugs?f_ri=137516"},{"id":623821,"name":"ANXIETY","url":"https://www.academia.edu/Documents/in/ANXIETY-1?f_ri=137516"},{"id":1120234,"name":"Alzheimer Disease","url":"https://www.academia.edu/Documents/in/Alzheimer_Disease?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13207407 coauthored" data-work_id="13207407" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13207407/Intensive_Motivational_Interviewing_for_women_with_concurrent_alcohol_problems_and_methamphetamine_dependence">Intensive Motivational Interviewing for women with concurrent alcohol problems and methamphetamine dependence</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Motivational interviewing (MI) for the treatment of alcohol and drug problems is typically conducted over 1 to 3 sessions. The current work evaluates an intensive 9-session version of MI (Intensive MI) compared to a standard single MI... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13207407" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Motivational interviewing (MI) for the treatment of alcohol and drug problems is typically conducted over 1 to 3 sessions. The current work evaluates an intensive 9-session version of MI (Intensive MI) compared to a standard single MI session (Standard MI) using 163 methamphetamine (MA) dependent individuals. The primary purpose of this paper is to report the unexpected finding that women with co-occurring alcohol problems in the Intensive MI condition reduced the severity of their alcohol problems significantly more than women in the Standard MI condition at the 6-month follow-up. Stronger perceived alliance with the therapist was inversely associated with alcohol problem severity scores. Findings indicate that Intensive MI is a beneficial treatment for alcohol problems among women with MA dependence.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13207407" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f43abb91f80c76b3eb4121eee5f25410" rel="nofollow" data-download="{"attachment_id":45685873,"asset_id":13207407,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45685873/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32462465" href="https://independent.academia.edu/DouglasPolcin">Douglas Polcin</a><script data-card-contents-for-user="32462465" type="text/json">{"id":32462465,"first_name":"Douglas","last_name":"Polcin","domain_name":"independent","page_name":"DouglasPolcin","display_name":"Douglas Polcin","profile_url":"https://independent.academia.edu/DouglasPolcin?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-13207407">+1</span><div class="hidden js-additional-users-13207407"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://cpmc.academia.edu/GanttGalloway">Gantt Galloway</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-13207407'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-13207407').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_13207407 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13207407"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13207407, container: ".js-paper-rank-work_13207407", }); });</script></li><li class="js-percentile-work_13207407 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13207407; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13207407"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13207407 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13207407"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13207407; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13207407]").text(description); $(".js-view-count-work_13207407").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13207407").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13207407"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">8</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="44274" rel="nofollow" href="https://www.academia.edu/Documents/in/Motivational_Interviewing">Motivational Interviewing</a>, <script data-card-contents-for-ri="44274" type="text/json">{"id":44274,"name":"Motivational Interviewing","url":"https://www.academia.edu/Documents/in/Motivational_Interviewing?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="44275" rel="nofollow" href="https://www.academia.edu/Documents/in/Substance_Abuse_Treatment">Substance Abuse Treatment</a><script data-card-contents-for-ri="44275" type="text/json">{"id":44275,"name":"Substance Abuse Treatment","url":"https://www.academia.edu/Documents/in/Substance_Abuse_Treatment?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13207407]'), work: {"id":13207407,"title":"Intensive Motivational Interviewing for women with concurrent alcohol problems and methamphetamine dependence","created_at":"2015-06-23T06:15:26.229-07:00","url":"https://www.academia.edu/13207407/Intensive_Motivational_Interviewing_for_women_with_concurrent_alcohol_problems_and_methamphetamine_dependence?f_ri=137516","dom_id":"work_13207407","summary":"Motivational interviewing (MI) for the treatment of alcohol and drug problems is typically conducted over 1 to 3 sessions. The current work evaluates an intensive 9-session version of MI (Intensive MI) compared to a standard single MI session (Standard MI) using 163 methamphetamine (MA) dependent individuals. The primary purpose of this paper is to report the unexpected finding that women with co-occurring alcohol problems in the Intensive MI condition reduced the severity of their alcohol problems significantly more than women in the Standard MI condition at the 6-month follow-up. Stronger perceived alliance with the therapist was inversely associated with alcohol problem severity scores. Findings indicate that Intensive MI is a beneficial treatment for alcohol problems among women with MA dependence.","downloadable_attachments":[{"id":45685873,"asset_id":13207407,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32462465,"first_name":"Douglas","last_name":"Polcin","domain_name":"independent","page_name":"DouglasPolcin","display_name":"Douglas Polcin","profile_url":"https://independent.academia.edu/DouglasPolcin?f_ri=137516","photo":"/images/s65_no_pic.png"},{"id":33952710,"first_name":"Gantt","last_name":"Galloway","domain_name":"cpmc","page_name":"GanttGalloway","display_name":"Gantt Galloway","profile_url":"https://cpmc.academia.edu/GanttGalloway?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":44274,"name":"Motivational Interviewing","url":"https://www.academia.edu/Documents/in/Motivational_Interviewing?f_ri=137516","nofollow":true},{"id":44275,"name":"Substance Abuse Treatment","url":"https://www.academia.edu/Documents/in/Substance_Abuse_Treatment?f_ri=137516","nofollow":true},{"id":100292,"name":"Methamphetamine","url":"https://www.academia.edu/Documents/in/Methamphetamine?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=137516"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17608961" data-work_id="17608961" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17608961/Dumping_Symptoms_and_Incidence_of_Hypoglycaemia_After_Provocation_Test_at_6_and_12_Months_After_Laparoscopic_Sleeve_Gastrectomy">Dumping Symptoms and Incidence of Hypoglycaemia After Provocation Test at 6 and 12 Months After Laparoscopic Sleeve Gastrectomy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background A previous study has demonstrated that symptoms suggestive of dumping syndrome appear after a provocation test early after laparoscopic sleeve gastrectomy (LSG) in 45 % of patients, and these are mainly related to early... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17608961" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background A previous study has demonstrated that symptoms suggestive of dumping syndrome appear after a provocation test early after laparoscopic sleeve gastrectomy (LSG) in 45 % of patients, and these are mainly related to early dumping. The aim of this study is to evaluate the evolution of dumping symptoms during the first postoperative year. Methods Twenty-five non-diabetic morbidly obese patients (6 male, 19 female) were evaluated with an oral glucose tolerance test (OGTT) preoperatively, at 6 weeks and at 6 months postoperatively. In addition, 12 of them repeated the OGTT at 12 months after LSG. Sigstad score was used to separate dumpers from non-dumpers and Arts' questionnaire to differentiate between early and late dumping. Insulin and glucose levels were also measured. Results Sigstad score remained significantly elevated at 6 and 12 months postoperatively compared to preoperative values. Symptoms suggestive of dumping syndrome were recorded in 40 % of patients at 6 months and in 33 % at 12 months postoperatively. Arts' questionnaire demonstrated that early dumping score remained higher compared to baseline at 6 and 12 months postoperatively. Late dumping scores increased gradually during the time and that difference was statistically significant at 12 months after LSG. Hypoglycaemia occurred at 33 % of patients both at 6 and 12 months postoperatively.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17608961" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a299f94201f85d8f103a0441ca99895f" rel="nofollow" data-download="{"attachment_id":39610981,"asset_id":17608961,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39610981/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37453581" href="https://independent.academia.edu/DimitrisZacharoulis">Dimitris Zacharoulis</a><script data-card-contents-for-user="37453581" type="text/json">{"id":37453581,"first_name":"Dimitris","last_name":"Zacharoulis","domain_name":"independent","page_name":"DimitrisZacharoulis","display_name":"Dimitris Zacharoulis","profile_url":"https://independent.academia.edu/DimitrisZacharoulis?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17608961 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17608961"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17608961, container: ".js-paper-rank-work_17608961", }); 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$(".js-view-count[data-work-id=17608961]").text(description); $(".js-view-count-work_17608961").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_17608961").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="17608961"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">13</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="116895" rel="nofollow" href="https://www.academia.edu/Documents/in/Hypoglycemia">Hypoglycemia</a>, <script data-card-contents-for-ri="116895" type="text/json">{"id":116895,"name":"Hypoglycemia","url":"https://www.academia.edu/Documents/in/Hypoglycemia?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a>, <script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="174502" rel="nofollow" href="https://www.academia.edu/Documents/in/Incidence">Incidence</a><script data-card-contents-for-ri="174502" type="text/json">{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=17608961]'), work: {"id":17608961,"title":"Dumping Symptoms and Incidence of Hypoglycaemia After Provocation Test at 6 and 12 Months After Laparoscopic Sleeve Gastrectomy","created_at":"2015-11-02T05:49:13.085-08:00","url":"https://www.academia.edu/17608961/Dumping_Symptoms_and_Incidence_of_Hypoglycaemia_After_Provocation_Test_at_6_and_12_Months_After_Laparoscopic_Sleeve_Gastrectomy?f_ri=137516","dom_id":"work_17608961","summary":"Background A previous study has demonstrated that symptoms suggestive of dumping syndrome appear after a provocation test early after laparoscopic sleeve gastrectomy (LSG) in 45 % of patients, and these are mainly related to early dumping. The aim of this study is to evaluate the evolution of dumping symptoms during the first postoperative year. Methods Twenty-five non-diabetic morbidly obese patients (6 male, 19 female) were evaluated with an oral glucose tolerance test (OGTT) preoperatively, at 6 weeks and at 6 months postoperatively. In addition, 12 of them repeated the OGTT at 12 months after LSG. Sigstad score was used to separate dumpers from non-dumpers and Arts' questionnaire to differentiate between early and late dumping. Insulin and glucose levels were also measured. Results Sigstad score remained significantly elevated at 6 and 12 months postoperatively compared to preoperative values. Symptoms suggestive of dumping syndrome were recorded in 40 % of patients at 6 months and in 33 % at 12 months postoperatively. Arts' questionnaire demonstrated that early dumping score remained higher compared to baseline at 6 and 12 months postoperatively. Late dumping scores increased gradually during the time and that difference was statistically significant at 12 months after LSG. Hypoglycaemia occurred at 33 % of patients both at 6 and 12 months postoperatively.","downloadable_attachments":[{"id":39610981,"asset_id":17608961,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37453581,"first_name":"Dimitris","last_name":"Zacharoulis","domain_name":"independent","page_name":"DimitrisZacharoulis","display_name":"Dimitris Zacharoulis","profile_url":"https://independent.academia.edu/DimitrisZacharoulis?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":116895,"name":"Hypoglycemia","url":"https://www.academia.edu/Documents/in/Hypoglycemia?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=137516","nofollow":true},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index?f_ri=137516"},{"id":202574,"name":"Feeding Behavior","url":"https://www.academia.edu/Documents/in/Feeding_Behavior?f_ri=137516"},{"id":218811,"name":"Obesity Surgery","url":"https://www.academia.edu/Documents/in/Obesity_Surgery?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=137516"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=137516"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=137516"},{"id":901298,"name":"Glucose Tolerance Test","url":"https://www.academia.edu/Documents/in/Glucose_Tolerance_Test?f_ri=137516"},{"id":1229542,"name":"Laparoscopy","url":"https://www.academia.edu/Documents/in/Laparoscopy?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24218485" data-work_id="24218485" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24218485/The_Purse_String_Reinforced_SMASectomy_Short_Scar_Facelift">The Purse-String Reinforced SMASectomy Short Scar Facelift</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24218485" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5c5deb0baee924509f84e363ee2516db" rel="nofollow" data-download="{"attachment_id":44548893,"asset_id":24218485,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44548893/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46673549" href="https://umcg.academia.edu/BerendvanderLei">Berend van der Lei</a><script data-card-contents-for-user="46673549" type="text/json">{"id":46673549,"first_name":"Berend van der","last_name":"Lei","domain_name":"umcg","page_name":"BerendvanderLei","display_name":"Berend van der Lei","profile_url":"https://umcg.academia.edu/BerendvanderLei?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24218485 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24218485"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24218485, container: ".js-paper-rank-work_24218485", }); 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$(".js-view-count[data-work-id=24218485]").text(description); $(".js-view-count-work_24218485").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24218485").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24218485"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">9</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="651" rel="nofollow" href="https://www.academia.edu/Documents/in/Plastic_Surgery">Plastic Surgery</a>, <script data-card-contents-for-ri="651" type="text/json">{"id":651,"name":"Plastic Surgery","url":"https://www.academia.edu/Documents/in/Plastic_Surgery?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="133057" rel="nofollow" href="https://www.academia.edu/Documents/in/Young_Adult">Young Adult</a>, <script data-card-contents-for-ri="133057" type="text/json">{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a><script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24218485]'), work: {"id":24218485,"title":"The Purse-String Reinforced SMASectomy Short Scar Facelift","created_at":"2016-04-08T13:22:18.930-07:00","url":"https://www.academia.edu/24218485/The_Purse_String_Reinforced_SMASectomy_Short_Scar_Facelift?f_ri=137516","dom_id":"work_24218485","summary":null,"downloadable_attachments":[{"id":44548893,"asset_id":24218485,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":46673549,"first_name":"Berend van der","last_name":"Lei","domain_name":"umcg","page_name":"BerendvanderLei","display_name":"Berend van der Lei","profile_url":"https://umcg.academia.edu/BerendvanderLei?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":651,"name":"Plastic Surgery","url":"https://www.academia.edu/Documents/in/Plastic_Surgery?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":144052,"name":"Patient Satisfaction","url":"https://www.academia.edu/Documents/in/Patient_Satisfaction?f_ri=137516"},{"id":213076,"name":"Aesthetic Surgery","url":"https://www.academia.edu/Documents/in/Aesthetic_Surgery?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=137516"},{"id":847988,"name":"Neck","url":"https://www.academia.edu/Documents/in/Neck?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27976060" data-work_id="27976060" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27976060/Management_of_cochlear_implantation_in_patients_with_malformations">Management of cochlear implantation in patients with malformations</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Dear Editor, Cochlear implantation in congenital and acquired deafness is an approved auditory rehabilitation treatment. Malformations are of special interest nowadays, as the indication for cochlear implant surgery is expanding.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27976060" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Dear Editor, Cochlear implantation in congenital and acquired deafness is an approved auditory rehabilitation treatment. Malformations are of special interest nowadays, as the indication for cochlear implant surgery is expanding. Inner-ear malformations constitute about 20% of congenital sensorineural hearing loss. 1 In a retrospective evaluation, we found 12% malformations in children and 3% malformations in adults. 2 In 1987, Jackler 1 presented a classification of inner-ear malformations, based on the embryological genesis. Sennaroglu and Saatci 3 suggested an extension, based on the initial classification. The basic classification distinguishes malformations of the cochlea and vestibular labyrinth, and additionally abnormalities of the internal auditory canal (IAC). This classification provides an excellent basis for detecting malformations of the inner ear. Nevertheless, it must be expanded to include malformations due to syndromes, which, in their complexity, are not simple to classify, for example innerear malformations in Mondini dysplasia, CHARGE-syndrome and X-linked deafness syndrome. We used these classifications in 29 patients as a basis for a newly developed flow chart which enabled us to preoperatively calculate adaptation of the surgical procedure according to the extent of the malformations. The description of our flow chart is based on two patients with complex malformations of the labyrinth.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27976060" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ddb0965691b9ba7e8555e56005bc71c5" rel="nofollow" data-download="{"attachment_id":48278965,"asset_id":27976060,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48278965/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32519027" href="https://independent.academia.edu/RolandLaszig">Roland Laszig</a><script data-card-contents-for-user="32519027" type="text/json">{"id":32519027,"first_name":"Roland","last_name":"Laszig","domain_name":"independent","page_name":"RolandLaszig","display_name":"Roland Laszig","profile_url":"https://independent.academia.edu/RolandLaszig?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_27976060 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27976060"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27976060, container: ".js-paper-rank-work_27976060", }); 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$(".js-view-count[data-work-id=27976060]").text(description); $(".js-view-count-work_27976060").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27976060").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27976060"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">10</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="5391" rel="nofollow" href="https://www.academia.edu/Documents/in/Speech_perception">Speech perception</a>, <script data-card-contents-for-ri="5391" type="text/json">{"id":5391,"name":"Speech perception","url":"https://www.academia.edu/Documents/in/Speech_perception?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="69542" rel="nofollow" href="https://www.academia.edu/Documents/in/Computer_Simulation">Computer Simulation</a>, <script data-card-contents-for-ri="69542" type="text/json">{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="76622" rel="nofollow" href="https://www.academia.edu/Documents/in/Cochlear_Implant">Cochlear Implant</a>, <script data-card-contents-for-ri="76622" type="text/json">{"id":76622,"name":"Cochlear Implant","url":"https://www.academia.edu/Documents/in/Cochlear_Implant?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="134346" rel="nofollow" href="https://www.academia.edu/Documents/in/Infant">Infant</a><script data-card-contents-for-ri="134346" type="text/json">{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27976060]'), work: {"id":27976060,"title":"Management of cochlear implantation in patients with malformations","created_at":"2016-08-24T04:57:53.472-07:00","url":"https://www.academia.edu/27976060/Management_of_cochlear_implantation_in_patients_with_malformations?f_ri=137516","dom_id":"work_27976060","summary":"Dear Editor, Cochlear implantation in congenital and acquired deafness is an approved auditory rehabilitation treatment. Malformations are of special interest nowadays, as the indication for cochlear implant surgery is expanding. Inner-ear malformations constitute about 20% of congenital sensorineural hearing loss. 1 In a retrospective evaluation, we found 12% malformations in children and 3% malformations in adults. 2 In 1987, Jackler 1 presented a classification of inner-ear malformations, based on the embryological genesis. Sennaroglu and Saatci 3 suggested an extension, based on the initial classification. The basic classification distinguishes malformations of the cochlea and vestibular labyrinth, and additionally abnormalities of the internal auditory canal (IAC). This classification provides an excellent basis for detecting malformations of the inner ear. Nevertheless, it must be expanded to include malformations due to syndromes, which, in their complexity, are not simple to classify, for example innerear malformations in Mondini dysplasia, CHARGE-syndrome and X-linked deafness syndrome. We used these classifications in 29 patients as a basis for a newly developed flow chart which enabled us to preoperatively calculate adaptation of the surgical procedure according to the extent of the malformations. The description of our flow chart is based on two patients with complex malformations of the labyrinth.","downloadable_attachments":[{"id":48278965,"asset_id":27976060,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32519027,"first_name":"Roland","last_name":"Laszig","domain_name":"independent","page_name":"RolandLaszig","display_name":"Roland Laszig","profile_url":"https://independent.academia.edu/RolandLaszig?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":5391,"name":"Speech perception","url":"https://www.academia.edu/Documents/in/Speech_perception?f_ri=137516","nofollow":true},{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation?f_ri=137516","nofollow":true},{"id":76622,"name":"Cochlear Implant","url":"https://www.academia.edu/Documents/in/Cochlear_Implant?f_ri=137516","nofollow":true},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":197299,"name":"Inner Ear","url":"https://www.academia.edu/Documents/in/Inner_Ear?f_ri=137516"},{"id":226636,"name":"Deafness","url":"https://www.academia.edu/Documents/in/Deafness?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":1253980,"name":"Cochlear Implantation","url":"https://www.academia.edu/Documents/in/Cochlear_Implantation?f_ri=137516"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13905579 coauthored" data-work_id="13905579" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13905579/Percutaneous_left_atrial_appendage_closure_with_an_epicardial_suture_ligation_approach_A_prospective_randomized_pre_clinical_feasibility_study">Percutaneous left atrial appendage closure with an epicardial suture ligation approach: A prospective randomized pre-clinical feasibility study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of this study was to evaluate the results associated with left atrial appendage closure (LAAC) with the AMPLATZER Cardiac Plug (ACP) (St. Jude Medical, Minneapolis, Minnesota) in patients with nonvalvular atrial fibrillation and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13905579" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of this study was to evaluate the results associated with left atrial appendage closure (LAAC) with the AMPLATZER Cardiac Plug (ACP) (St. Jude Medical, Minneapolis, Minnesota) in patients with nonvalvular atrial fibrillation and absolute contraindications to anticoagulation therapy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13905579" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4078b4b9ba209ec8fd732674c2863ae9" rel="nofollow" data-download="{"attachment_id":44816882,"asset_id":13905579,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44816882/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32976510" href="https://independent.academia.edu/DAvilaAndr%C3%A9">André D'Avila</a><script data-card-contents-for-user="32976510" type="text/json">{"id":32976510,"first_name":"André","last_name":"D'Avila","domain_name":"independent","page_name":"DAvilaAndré","display_name":"André D'Avila","profile_url":"https://independent.academia.edu/DAvilaAndr%C3%A9?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-13905579">+1</span><div class="hidden js-additional-users-13905579"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/ShephalDoshi">Shephal Doshi</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-13905579'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-13905579').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_13905579 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13905579"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13905579, container: ".js-paper-rank-work_13905579", }); });</script></li><li class="js-percentile-work_13905579 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13905579; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13905579"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13905579 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13905579"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13905579; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13905579]").text(description); $(".js-view-count-work_13905579").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13905579").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13905579"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">17</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1131" rel="nofollow" href="https://www.academia.edu/Documents/in/Biomedical_Engineering">Biomedical Engineering</a>, <script data-card-contents-for-ri="1131" type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="44526" rel="nofollow" href="https://www.academia.edu/Documents/in/Feasibility_Study">Feasibility Study</a><script data-card-contents-for-ri="44526" type="text/json">{"id":44526,"name":"Feasibility Study","url":"https://www.academia.edu/Documents/in/Feasibility_Study?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13905579]'), work: {"id":13905579,"title":"Percutaneous left atrial appendage closure with an epicardial suture ligation approach: A prospective randomized pre-clinical feasibility study","created_at":"2015-07-10T23:38:16.011-07:00","url":"https://www.academia.edu/13905579/Percutaneous_left_atrial_appendage_closure_with_an_epicardial_suture_ligation_approach_A_prospective_randomized_pre_clinical_feasibility_study?f_ri=137516","dom_id":"work_13905579","summary":"The aim of this study was to evaluate the results associated with left atrial appendage closure (LAAC) with the AMPLATZER Cardiac Plug (ACP) (St. Jude Medical, Minneapolis, Minnesota) in patients with nonvalvular atrial fibrillation and absolute contraindications to anticoagulation therapy.","downloadable_attachments":[{"id":44816882,"asset_id":13905579,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32976510,"first_name":"André","last_name":"D'Avila","domain_name":"independent","page_name":"DAvilaAndré","display_name":"André D'Avila","profile_url":"https://independent.academia.edu/DAvilaAndr%C3%A9?f_ri=137516","photo":"/images/s65_no_pic.png"},{"id":33018856,"first_name":"Shephal","last_name":"Doshi","domain_name":"independent","page_name":"ShephalDoshi","display_name":"Shephal Doshi","profile_url":"https://independent.academia.edu/ShephalDoshi?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=137516","nofollow":true},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":44526,"name":"Feasibility Study","url":"https://www.academia.edu/Documents/in/Feasibility_Study?f_ri=137516","nofollow":true},{"id":61234,"name":"Stroke","url":"https://www.academia.edu/Documents/in/Stroke?f_ri=137516"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=137516"},{"id":100540,"name":"Feasibility Studies","url":"https://www.academia.edu/Documents/in/Feasibility_Studies?f_ri=137516"},{"id":130890,"name":"Atrial Fibrillation","url":"https://www.academia.edu/Documents/in/Atrial_Fibrillation?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":176423,"name":"Thromboembolism","url":"https://www.academia.edu/Documents/in/Thromboembolism?f_ri=137516"},{"id":189949,"name":"Anticoagulants","url":"https://www.academia.edu/Documents/in/Anticoagulants?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=137516"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=137516"},{"id":419370,"name":"Swine","url":"https://www.academia.edu/Documents/in/Swine?f_ri=137516"},{"id":496063,"name":"Thrombosis","url":"https://www.academia.edu/Documents/in/Thrombosis?f_ri=137516"},{"id":546400,"name":"Postoperative Hemorrhage","url":"https://www.academia.edu/Documents/in/Postoperative_Hemorrhage?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14079322 coauthored" data-work_id="14079322" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14079322/The_BIG_brain_injury_guidelines_project_defining_the_management_of_traumatic_brain_injury_by_acute_care_surgeons">The BIG (brain injury guidelines) project: defining the management of traumatic brain injury by acute care surgeons</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">It is becoming a standard practice that any &quot;positive&quot; identification of a radiographic intracranial injury requires transfer of the patient to a trauma center for observation and repeat head computed tomography (RHCT). The... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14079322" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">It is becoming a standard practice that any &quot;positive&quot; identification of a radiographic intracranial injury requires transfer of the patient to a trauma center for observation and repeat head computed tomography (RHCT). The purpose of this study was to define guidelines-based on each patient&#39;s history, physical examination, and initial head CT findings-regarding which patients require a period of observation, RHCT, or neurosurgical consultation. In our retrospective cohort analysis, we reviewed the records of 3,803 blunt traumatic brain injury patients during a 4-year period. We classified patients according to neurologic examination results, use of intoxicants, anticoagulation status, and initial head CT findings. We then developed brain injury guidelines (BIG) based on the individual patient&#39;s need for observation or hospitalization, RHCT, or neurosurgical consultation. A total of 1,232 patients had an abnormal head CT finding. In the BIG 1 category, no patients ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14079322" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4f263e964074d012ed2ee95792334fb7" rel="nofollow" data-download="{"attachment_id":44628823,"asset_id":14079322,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44628823/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33091299" href="https://independent.academia.edu/BellalJoseph">Bellal Joseph</a><script data-card-contents-for-user="33091299" type="text/json">{"id":33091299,"first_name":"Bellal","last_name":"Joseph","domain_name":"independent","page_name":"BellalJoseph","display_name":"Bellal Joseph","profile_url":"https://independent.academia.edu/BellalJoseph?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-14079322">+1</span><div class="hidden js-additional-users-14079322"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/PeterRhee">Peter Rhee</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-14079322'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-14079322').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_14079322 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14079322"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14079322, container: ".js-paper-rank-work_14079322", }); });</script></li><li class="js-percentile-work_14079322 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14079322; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_14079322"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14079322 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14079322"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14079322; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14079322]").text(description); $(".js-view-count-work_14079322").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14079322").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14079322"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">5</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="132366" rel="nofollow" href="https://www.academia.edu/Documents/in/Glasgow_Coma_Scale">Glasgow Coma Scale</a>, <script data-card-contents-for-ri="132366" type="text/json">{"id":132366,"name":"Glasgow Coma Scale","url":"https://www.academia.edu/Documents/in/Glasgow_Coma_Scale?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a>, <script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="469105" rel="nofollow" href="https://www.academia.edu/Documents/in/Retrospective_Studies">Retrospective Studies</a>, <script data-card-contents-for-ri="469105" type="text/json">{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="549280" rel="nofollow" href="https://www.academia.edu/Documents/in/Reproducibility_of_Results">Reproducibility of Results</a><script data-card-contents-for-ri="549280" type="text/json">{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14079322]'), work: {"id":14079322,"title":"The BIG (brain injury guidelines) project: defining the management of traumatic brain injury by acute care surgeons","created_at":"2015-07-15T08:46:33.274-07:00","url":"https://www.academia.edu/14079322/The_BIG_brain_injury_guidelines_project_defining_the_management_of_traumatic_brain_injury_by_acute_care_surgeons?f_ri=137516","dom_id":"work_14079322","summary":"It is becoming a standard practice that any \u0026quot;positive\u0026quot; identification of a radiographic intracranial injury requires transfer of the patient to a trauma center for observation and repeat head computed tomography (RHCT). The purpose of this study was to define guidelines-based on each patient\u0026#39;s history, physical examination, and initial head CT findings-regarding which patients require a period of observation, RHCT, or neurosurgical consultation. In our retrospective cohort analysis, we reviewed the records of 3,803 blunt traumatic brain injury patients during a 4-year period. We classified patients according to neurologic examination results, use of intoxicants, anticoagulation status, and initial head CT findings. We then developed brain injury guidelines (BIG) based on the individual patient\u0026#39;s need for observation or hospitalization, RHCT, or neurosurgical consultation. A total of 1,232 patients had an abnormal head CT finding. In the BIG 1 category, no patients ...","downloadable_attachments":[{"id":44628823,"asset_id":14079322,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33091299,"first_name":"Bellal","last_name":"Joseph","domain_name":"independent","page_name":"BellalJoseph","display_name":"Bellal Joseph","profile_url":"https://independent.academia.edu/BellalJoseph?f_ri=137516","photo":"/images/s65_no_pic.png"},{"id":38264902,"first_name":"Peter","last_name":"Rhee","domain_name":"independent","page_name":"PeterRhee","display_name":"Peter Rhee","profile_url":"https://independent.academia.edu/PeterRhee?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":132366,"name":"Glasgow Coma Scale","url":"https://www.academia.edu/Documents/in/Glasgow_Coma_Scale?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=137516","nofollow":true},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=137516","nofollow":true},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27964158" data-work_id="27964158" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27964158/Psychotropic_medication_in_chronic_spinal_disorders_1">Psychotropic medication in chronic spinal disorders*1</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">BACKGROUND CONTEXT: Optimal treatment of nonmalignant chronic spinal disorders (CSDs) may require the use of one or more nonopioid psychotropic medications. Vast research literature has documented high rates of psychiatric disorders in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27964158" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">BACKGROUND CONTEXT: Optimal treatment of nonmalignant chronic spinal disorders (CSDs) may require the use of one or more nonopioid psychotropic medications. Vast research literature has documented high rates of psychiatric disorders in patients with CSDs. Psychotropic medications are one type of effective treatment for these disorders. Many medications of this type are also used as adjuvants to primary analgesic medications. PURPOSE: Physicians treating CSDs may have little training and experience in prescribing psychotropic medications. Further, they may possess limited information about the efficacy of these types of medications in treating psychiatric disorders comorbid with CSDs or as adjunctive analgesics. Because of the wide variety (antidepressants, anxiolytics, sleep-promoting agents, anticonvulsants, neuroleptics, muscle relaxants) and numerous indications for psychiatric medications, a concise review of the use of psychotropic medications with CSD patients is offered for the spine specialist. STUDY DESIGN: A systematic review of the contemporary English literature on psychotropic medications in the CSD population. METHODS: A computerized search of MEDLINE was performed on all English literature published from 1982 to August 2002. RESULTS: Psychotropic medications have been found to be very efficacious in the large subgroup of patients with CSDs with psychiatric comorbidity, particularly patients with the common constellation of depression, anxiety, excessive somatic complaints, insomnia and irritability. Although the type of medication indicated depends on the particular psychiatric syndrome(s), antidepressants have been found to be extremely useful with the constellation described above. There is less evidence to support the use of nonopioid psychotropic medications in the treatment of nociceptive pain, although clinical experience indicates that some individuals demonstrate a marked analgesic response. Research support for the efficacy of particular psychotropic medications in treating neuropathic pain is stronger, although more controlled research is clearly needed. CONCLUSIONS: Psychotropic medications are extremely useful in the treatment of psychiatric disorders comorbid with CSDs and modestly useful as analgesic adjuvants, particularly with pain of neuropathic etiology. Familiarity with these medications will aid the primary treating physician in optimizing outcomes in this difficult group of patients. Ć</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27964158" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6de70187bc0b576086d23bca614527ac" rel="nofollow" data-download="{"attachment_id":48266364,"asset_id":27964158,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48266364/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52324212" href="https://independent.academia.edu/JeromeSchofferman">Jerome Schofferman</a><script data-card-contents-for-user="52324212" type="text/json">{"id":52324212,"first_name":"Jerome","last_name":"Schofferman","domain_name":"independent","page_name":"JeromeSchofferman","display_name":"Jerome Schofferman","profile_url":"https://independent.academia.edu/JeromeSchofferman?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_27964158 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27964158"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27964158, container: ".js-paper-rank-work_27964158", }); });</script></li><li class="js-percentile-work_27964158 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27964158; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_27964158"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_27964158 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="27964158"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27964158; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27964158]").text(description); $(".js-view-count-work_27964158").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27964158").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27964158"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">21</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2047" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychopharmacology">Psychopharmacology</a>, <script data-card-contents-for-ri="2047" type="text/json">{"id":2047,"name":"Psychopharmacology","url":"https://www.academia.edu/Documents/in/Psychopharmacology?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4479" rel="nofollow" href="https://www.academia.edu/Documents/in/Chronic_Pain">Chronic Pain</a>, <script data-card-contents-for-ri="4479" type="text/json">{"id":4479,"name":"Chronic Pain","url":"https://www.academia.edu/Documents/in/Chronic_Pain?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4933" rel="nofollow" href="https://www.academia.edu/Documents/in/Spine">Spine</a>, <script data-card-contents-for-ri="4933" type="text/json">{"id":4933,"name":"Spine","url":"https://www.academia.edu/Documents/in/Spine?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a><script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27964158]'), work: {"id":27964158,"title":"Psychotropic medication in chronic spinal disorders*1","created_at":"2016-08-23T17:50:36.253-07:00","url":"https://www.academia.edu/27964158/Psychotropic_medication_in_chronic_spinal_disorders_1?f_ri=137516","dom_id":"work_27964158","summary":"BACKGROUND CONTEXT: Optimal treatment of nonmalignant chronic spinal disorders (CSDs) may require the use of one or more nonopioid psychotropic medications. Vast research literature has documented high rates of psychiatric disorders in patients with CSDs. Psychotropic medications are one type of effective treatment for these disorders. Many medications of this type are also used as adjuvants to primary analgesic medications. PURPOSE: Physicians treating CSDs may have little training and experience in prescribing psychotropic medications. Further, they may possess limited information about the efficacy of these types of medications in treating psychiatric disorders comorbid with CSDs or as adjunctive analgesics. Because of the wide variety (antidepressants, anxiolytics, sleep-promoting agents, anticonvulsants, neuroleptics, muscle relaxants) and numerous indications for psychiatric medications, a concise review of the use of psychotropic medications with CSD patients is offered for the spine specialist. STUDY DESIGN: A systematic review of the contemporary English literature on psychotropic medications in the CSD population. METHODS: A computerized search of MEDLINE was performed on all English literature published from 1982 to August 2002. RESULTS: Psychotropic medications have been found to be very efficacious in the large subgroup of patients with CSDs with psychiatric comorbidity, particularly patients with the common constellation of depression, anxiety, excessive somatic complaints, insomnia and irritability. Although the type of medication indicated depends on the particular psychiatric syndrome(s), antidepressants have been found to be extremely useful with the constellation described above. There is less evidence to support the use of nonopioid psychotropic medications in the treatment of nociceptive pain, although clinical experience indicates that some individuals demonstrate a marked analgesic response. Research support for the efficacy of particular psychotropic medications in treating neuropathic pain is stronger, although more controlled research is clearly needed. CONCLUSIONS: Psychotropic medications are extremely useful in the treatment of psychiatric disorders comorbid with CSDs and modestly useful as analgesic adjuvants, particularly with pain of neuropathic etiology. Familiarity with these medications will aid the primary treating physician in optimizing outcomes in this difficult group of patients. Ć","downloadable_attachments":[{"id":48266364,"asset_id":27964158,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":52324212,"first_name":"Jerome","last_name":"Schofferman","domain_name":"independent","page_name":"JeromeSchofferman","display_name":"Jerome Schofferman","profile_url":"https://independent.academia.edu/JeromeSchofferman?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2047,"name":"Psychopharmacology","url":"https://www.academia.edu/Documents/in/Psychopharmacology?f_ri=137516","nofollow":true},{"id":4479,"name":"Chronic Pain","url":"https://www.academia.edu/Documents/in/Chronic_Pain?f_ri=137516","nofollow":true},{"id":4933,"name":"Spine","url":"https://www.academia.edu/Documents/in/Spine?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=137516"},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=137516"},{"id":40208,"name":"Musculoskeletal Disease","url":"https://www.academia.edu/Documents/in/Musculoskeletal_Disease?f_ri=137516"},{"id":96959,"name":"Back Pain","url":"https://www.academia.edu/Documents/in/Back_Pain?f_ri=137516"},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":157943,"name":"Depressive Disorder","url":"https://www.academia.edu/Documents/in/Depressive_Disorder?f_ri=137516"},{"id":171144,"name":"Mental Disorders","url":"https://www.academia.edu/Documents/in/Mental_Disorders?f_ri=137516"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=137516"},{"id":211445,"name":"Mental Disorder","url":"https://www.academia.edu/Documents/in/Mental_Disorder?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":606036,"name":"Psychotropic Drugs","url":"https://www.academia.edu/Documents/in/Psychotropic_Drugs?f_ri=137516"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=137516"},{"id":836997,"name":"Anxiety Disorder","url":"https://www.academia.edu/Documents/in/Anxiety_Disorder?f_ri=137516"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=137516"},{"id":1262481,"name":"Pain Measurement","url":"https://www.academia.edu/Documents/in/Pain_Measurement?f_ri=137516"},{"id":2463800,"name":"Severity of Illness Index","url":"https://www.academia.edu/Documents/in/Severity_of_Illness_Index?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20046068" data-work_id="20046068" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20046068/Biologic_augmentation_of_rotator_cuff_repair_with_mesenchymal_stem_cells_during_arthroscopy_improves_healing_and_prevents_further_tears_a_case_controlled_study">Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The purpose of this study was to evaluate the efficiency of biologic augmentation of rotator cuff repair with iliac crest bone marrow-derived mesenchymal stem cells (MSCs). The prevalence of healing and prevention of re-tears were... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20046068" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The purpose of this study was to evaluate the efficiency of biologic augmentation of rotator cuff repair with iliac crest bone marrow-derived mesenchymal stem cells (MSCs). The prevalence of healing and prevention of re-tears were correlated with the number of MSCs received at the tendon-to-bone interface. Forty-five patients in the study group received concentrated bone marrow-derived MSCs as an adjunct to single-row rotator cuff repair at the time of arthroscopy. The average number of MSCs returned to the patient was 51,000 ± 25,000. Outcomes of patients receiving MSCs during their repair were compared to those of a matched control group of 45 patients who did not receive MSCs. All patients underwent imaging studies of the shoulder with iterative ultrasound performed every month from the first postoperative month to the 24th month. The rotator cuff healing or re-tear was confirmed with MRI postoperatively at three and six months, one and two years and at the most recent follow up ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20046068" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="17c3eeeeb396947ff0883eb3bede31a7" rel="nofollow" data-download="{"attachment_id":41233346,"asset_id":20046068,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41233346/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40992638" href="https://independent.academia.edu/S%C3%A9bastienZilber">Sébastien Zilber</a><script data-card-contents-for-user="40992638" type="text/json">{"id":40992638,"first_name":"Sébastien","last_name":"Zilber","domain_name":"independent","page_name":"SébastienZilber","display_name":"Sébastien Zilber","profile_url":"https://independent.academia.edu/S%C3%A9bastienZilber?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_20046068 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20046068"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20046068, container: ".js-paper-rank-work_20046068", }); 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$(".js-view-count[data-work-id=20046068]").text(description); $(".js-view-count-work_20046068").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20046068").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20046068"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">14</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8991" rel="nofollow" href="https://www.academia.edu/Documents/in/Wound_Healing">Wound Healing</a>, <script data-card-contents-for-ri="8991" type="text/json">{"id":8991,"name":"Wound Healing","url":"https://www.academia.edu/Documents/in/Wound_Healing?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12155" rel="nofollow" href="https://www.academia.edu/Documents/in/Tendon_and_Ligament_injuries">Tendon and Ligament injuries</a>, <script data-card-contents-for-ri="12155" type="text/json">{"id":12155,"name":"Tendon and Ligament injuries","url":"https://www.academia.edu/Documents/in/Tendon_and_Ligament_injuries?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a><script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20046068]'), work: {"id":20046068,"title":"Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study","created_at":"2016-01-05T14:59:58.238-08:00","url":"https://www.academia.edu/20046068/Biologic_augmentation_of_rotator_cuff_repair_with_mesenchymal_stem_cells_during_arthroscopy_improves_healing_and_prevents_further_tears_a_case_controlled_study?f_ri=137516","dom_id":"work_20046068","summary":"The purpose of this study was to evaluate the efficiency of biologic augmentation of rotator cuff repair with iliac crest bone marrow-derived mesenchymal stem cells (MSCs). The prevalence of healing and prevention of re-tears were correlated with the number of MSCs received at the tendon-to-bone interface. Forty-five patients in the study group received concentrated bone marrow-derived MSCs as an adjunct to single-row rotator cuff repair at the time of arthroscopy. The average number of MSCs returned to the patient was 51,000 ± 25,000. Outcomes of patients receiving MSCs during their repair were compared to those of a matched control group of 45 patients who did not receive MSCs. All patients underwent imaging studies of the shoulder with iterative ultrasound performed every month from the first postoperative month to the 24th month. The rotator cuff healing or re-tear was confirmed with MRI postoperatively at three and six months, one and two years and at the most recent follow up ...","downloadable_attachments":[{"id":41233346,"asset_id":20046068,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":40992638,"first_name":"Sébastien","last_name":"Zilber","domain_name":"independent","page_name":"SébastienZilber","display_name":"Sébastien Zilber","profile_url":"https://independent.academia.edu/S%C3%A9bastienZilber?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=137516","nofollow":true},{"id":8991,"name":"Wound Healing","url":"https://www.academia.edu/Documents/in/Wound_Healing?f_ri=137516","nofollow":true},{"id":12155,"name":"Tendon and Ligament injuries","url":"https://www.academia.edu/Documents/in/Tendon_and_Ligament_injuries?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":38237,"name":"Bone Regeneration","url":"https://www.academia.edu/Documents/in/Bone_Regeneration?f_ri=137516"},{"id":43934,"name":"Orthopaedics","url":"https://www.academia.edu/Documents/in/Orthopaedics?f_ri=137516"},{"id":82854,"name":"Rotator cuff","url":"https://www.academia.edu/Documents/in/Rotator_cuff?f_ri=137516"},{"id":118122,"name":"Arthroscopy","url":"https://www.academia.edu/Documents/in/Arthroscopy?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=137516"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=137516"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15674986" data-work_id="15674986" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15674986/Pre_loss_symptoms_related_to_risk_of_complicated_grief_in_caregivers_of_terminally_ill_cancer_patients">Pre-loss symptoms related to risk of complicated grief in caregivers of terminally ill cancer patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose: A number of studies have underlined a 10-20% prevalence of complicated grief (CG) among caregivers of cancer patients. The study aimed at examining the relationship between pre-loss criteria for CG and post-loss diagnosis of CG... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_15674986" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose: A number of studies have underlined a 10-20% prevalence of complicated grief (CG) among caregivers of cancer patients. The study aimed at examining the relationship between pre-loss criteria for CG and post-loss diagnosis of CG and at evaluating the validity and factor structure of a predictive tool, the Inventory of Complicated Grief (ICG), in order to identify the risk of developing CG in a sample of Italian caregivers. Methods: Sixty family members of terminally ill patients admitted to hospice and receiving a Palliative Prognostic Score (PaP) predictive 30 day survival time o30% completed the Pre-Death ICG (ICG-PL) (T0). Family members were met again 6 months after the death of their loved one (T1) and submitted to the interview for Complicated Grief (Post-loss interview-PLI). Results: Caseness for CG was shown in 18.3% of caregivers at T1. ICG-PL score (T0) were higher among those who developed CG at T1 than non-cases. A cut off score Z49 on the ICG-PL (AUC ¼ 0.98) maximized sensitivity (92%) and specificity (98%) on caseness at T1. Pre-loss criteria related to traumatic distress, separation distress and emotional symptoms in general were significantly related to a post-loss diagnosis of CG, while no effect was shown on duration of pre-loss distress. Conclusions: The use of short screening tools, like the ICG-PL, may help health care professionals to identify subjects at risk for CG.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15674986" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ba81d4f6c198c35fe91b790120260098" rel="nofollow" data-download="{"attachment_id":42979689,"asset_id":15674986,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42979689/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34861339" href="https://independent.academia.edu/GrassiLuigi">Luigi Grassi</a><script data-card-contents-for-user="34861339" type="text/json">{"id":34861339,"first_name":"Luigi","last_name":"Grassi","domain_name":"independent","page_name":"GrassiLuigi","display_name":"Luigi Grassi","profile_url":"https://independent.academia.edu/GrassiLuigi?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_15674986 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="15674986"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 15674986, container: ".js-paper-rank-work_15674986", }); 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$(".js-view-count[data-work-id=15674986]").text(description); $(".js-view-count-work_15674986").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_15674986").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="15674986"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">10</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="16664" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk_assessment">Risk assessment</a>, <script data-card-contents-for-ri="16664" type="text/json">{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="45213" rel="nofollow" href="https://www.academia.edu/Documents/in/Italy">Italy</a>, <script data-card-contents-for-ri="45213" type="text/json">{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="67516" rel="nofollow" href="https://www.academia.edu/Documents/in/Affective_Disorders">Affective Disorders</a>, <script data-card-contents-for-ri="67516" type="text/json">{"id":67516,"name":"Affective Disorders","url":"https://www.academia.edu/Documents/in/Affective_Disorders?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a><script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=15674986]'), work: {"id":15674986,"title":"Pre-loss symptoms related to risk of complicated grief in caregivers of terminally ill cancer patients","created_at":"2015-09-14T02:05:55.010-07:00","url":"https://www.academia.edu/15674986/Pre_loss_symptoms_related_to_risk_of_complicated_grief_in_caregivers_of_terminally_ill_cancer_patients?f_ri=137516","dom_id":"work_15674986","summary":"Purpose: A number of studies have underlined a 10-20% prevalence of complicated grief (CG) among caregivers of cancer patients. The study aimed at examining the relationship between pre-loss criteria for CG and post-loss diagnosis of CG and at evaluating the validity and factor structure of a predictive tool, the Inventory of Complicated Grief (ICG), in order to identify the risk of developing CG in a sample of Italian caregivers. Methods: Sixty family members of terminally ill patients admitted to hospice and receiving a Palliative Prognostic Score (PaP) predictive 30 day survival time o30% completed the Pre-Death ICG (ICG-PL) (T0). Family members were met again 6 months after the death of their loved one (T1) and submitted to the interview for Complicated Grief (Post-loss interview-PLI). Results: Caseness for CG was shown in 18.3% of caregivers at T1. ICG-PL score (T0) were higher among those who developed CG at T1 than non-cases. A cut off score Z49 on the ICG-PL (AUC ¼ 0.98) maximized sensitivity (92%) and specificity (98%) on caseness at T1. Pre-loss criteria related to traumatic distress, separation distress and emotional symptoms in general were significantly related to a post-loss diagnosis of CG, while no effect was shown on duration of pre-loss distress. Conclusions: The use of short screening tools, like the ICG-PL, may help health care professionals to identify subjects at risk for CG.","downloadable_attachments":[{"id":42979689,"asset_id":15674986,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34861339,"first_name":"Luigi","last_name":"Grassi","domain_name":"independent","page_name":"GrassiLuigi","display_name":"Luigi Grassi","profile_url":"https://independent.academia.edu/GrassiLuigi?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=137516","nofollow":true},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=137516","nofollow":true},{"id":67516,"name":"Affective Disorders","url":"https://www.academia.edu/Documents/in/Affective_Disorders?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":178369,"name":"Grief","url":"https://www.academia.edu/Documents/in/Grief?f_ri=137516"},{"id":201441,"name":"Caregivers","url":"https://www.academia.edu/Documents/in/Caregivers?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms?f_ri=137516"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=137516"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_28457127" data-work_id="28457127" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28457127/The_effect_of_pelvic_floor_muscle_exercise_on_women_with_chronic_non_specific_low_back_pain">The effect of pelvic floor muscle exercise on women with chronic non-specific low back pain</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/28457127" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6f8e8be5886e8705586a0f9db9c80589" rel="nofollow" data-download="{"attachment_id":48806075,"asset_id":28457127,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48806075/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="28131981" href="https://independent.academia.edu/MohammadMohsenibandpei">Mohammad Mohseni-bandpei</a><script data-card-contents-for-user="28131981" type="text/json">{"id":28131981,"first_name":"Mohammad","last_name":"Mohseni-bandpei","domain_name":"independent","page_name":"MohammadMohsenibandpei","display_name":"Mohammad Mohseni-bandpei","profile_url":"https://independent.academia.edu/MohammadMohsenibandpei?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_28457127 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="28457127"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 28457127, container: ".js-paper-rank-work_28457127", }); 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$(".js-view-count[data-work-id=28457127]").text(description); $(".js-view-count-work_28457127").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_28457127").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="28457127"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">8</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="4083" rel="nofollow" href="https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine">Complementary and Alternative Medicine</a>, <script data-card-contents-for-ri="4083" type="text/json">{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="25443" rel="nofollow" href="https://www.academia.edu/Documents/in/Exercise_therapy">Exercise therapy</a>, <script data-card-contents-for-ri="25443" type="text/json">{"id":25443,"name":"Exercise therapy","url":"https://www.academia.edu/Documents/in/Exercise_therapy?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="40760" rel="nofollow" href="https://www.academia.edu/Documents/in/Low_back_pain">Low back pain</a>, <script data-card-contents-for-ri="40760" type="text/json">{"id":40760,"name":"Low back pain","url":"https://www.academia.edu/Documents/in/Low_back_pain?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="74296" rel="nofollow" href="https://www.academia.edu/Documents/in/Bodywork">Bodywork</a><script data-card-contents-for-ri="74296" type="text/json">{"id":74296,"name":"Bodywork","url":"https://www.academia.edu/Documents/in/Bodywork?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=28457127]'), work: {"id":28457127,"title":"The effect of pelvic floor muscle exercise on women with chronic non-specific low back pain","created_at":"2016-09-13T10:51:35.901-07:00","url":"https://www.academia.edu/28457127/The_effect_of_pelvic_floor_muscle_exercise_on_women_with_chronic_non_specific_low_back_pain?f_ri=137516","dom_id":"work_28457127","summary":null,"downloadable_attachments":[{"id":48806075,"asset_id":28457127,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":28131981,"first_name":"Mohammad","last_name":"Mohseni-bandpei","domain_name":"independent","page_name":"MohammadMohsenibandpei","display_name":"Mohammad Mohseni-bandpei","profile_url":"https://independent.academia.edu/MohammadMohsenibandpei?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine?f_ri=137516","nofollow":true},{"id":25443,"name":"Exercise therapy","url":"https://www.academia.edu/Documents/in/Exercise_therapy?f_ri=137516","nofollow":true},{"id":40760,"name":"Low back pain","url":"https://www.academia.edu/Documents/in/Low_back_pain?f_ri=137516","nofollow":true},{"id":74296,"name":"Bodywork","url":"https://www.academia.edu/Documents/in/Bodywork?f_ri=137516","nofollow":true},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=137516"},{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":863963,"name":"Chronic Low Back Pain","url":"https://www.academia.edu/Documents/in/Chronic_Low_Back_Pain?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14319811" data-work_id="14319811" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14319811/Effectiveness_of_Adjunctive_Low_Dose_Doxycycline_Therapy_on_Clinical_Parameters_and_Gingival_Crevicular_Fluid_Laminin_5_%CE%B32_Chain_Levels_in_Chronic_Periodontitis">Effectiveness of Adjunctive Low-Dose Doxycycline Therapy on Clinical Parameters and Gingival Crevicular Fluid Laminin-5 γ2 Chain Levels in Chronic Periodontitis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: is involved in the apical migration of epithelial cells during the development of periodontal pockets. Low-dose doxycycline (LDD) can therapeutically modulate the host response with its non-antimicrobial properties. In the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14319811" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: is involved in the apical migration of epithelial cells during the development of periodontal pockets. Low-dose doxycycline (LDD) can therapeutically modulate the host response with its non-antimicrobial properties. In the present randomized, double-blind, placebo-controlled, parallel arm study, the effectiveness of LDD in combination with non-surgical periodontal therapy on gingival crevicular fluid (GCF) Ln-5 γ2 chain fragment levels and clinical parameters in patients with chronic periodontitis was examined over a 12-month period.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14319811" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c002e6e594861cc177378bd57a8e7c9c" rel="nofollow" data-download="{"attachment_id":44323604,"asset_id":14319811,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44323604/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33273345" href="https://ege.academia.edu/G%C3%BClAtilla">Gül Atilla</a><script data-card-contents-for-user="33273345" type="text/json">{"id":33273345,"first_name":"Gül","last_name":"Atilla","domain_name":"ege","page_name":"GülAtilla","display_name":"Gül Atilla","profile_url":"https://ege.academia.edu/G%C3%BClAtilla?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14319811 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14319811"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14319811, container: ".js-paper-rank-work_14319811", }); });</script></li><li class="js-percentile-work_14319811 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14319811; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_14319811"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14319811 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14319811"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14319811; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14319811]").text(description); $(".js-view-count-work_14319811").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14319811").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14319811"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">13</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="596" rel="nofollow" href="https://www.academia.edu/Documents/in/Dentistry">Dentistry</a>, <script data-card-contents-for-ri="596" type="text/json">{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="50515" rel="nofollow" href="https://www.academia.edu/Documents/in/Periodontology">Periodontology</a>, <script data-card-contents-for-ri="50515" type="text/json">{"id":50515,"name":"Periodontology","url":"https://www.academia.edu/Documents/in/Periodontology?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="72821" rel="nofollow" href="https://www.academia.edu/Documents/in/Low_Dose">Low Dose</a>, <script data-card-contents-for-ri="72821" type="text/json">{"id":72821,"name":"Low Dose","url":"https://www.academia.edu/Documents/in/Low_Dose?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="97269" rel="nofollow" href="https://www.academia.edu/Documents/in/Chronic_Disease">Chronic Disease</a><script data-card-contents-for-ri="97269" type="text/json">{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14319811]'), work: {"id":14319811,"title":"Effectiveness of Adjunctive Low-Dose Doxycycline Therapy on Clinical Parameters and Gingival Crevicular Fluid Laminin-5 γ2 Chain Levels in Chronic Periodontitis","created_at":"2015-07-22T23:39:12.853-07:00","url":"https://www.academia.edu/14319811/Effectiveness_of_Adjunctive_Low_Dose_Doxycycline_Therapy_on_Clinical_Parameters_and_Gingival_Crevicular_Fluid_Laminin_5_%CE%B32_Chain_Levels_in_Chronic_Periodontitis?f_ri=137516","dom_id":"work_14319811","summary":"Background: is involved in the apical migration of epithelial cells during the development of periodontal pockets. Low-dose doxycycline (LDD) can therapeutically modulate the host response with its non-antimicrobial properties. In the present randomized, double-blind, placebo-controlled, parallel arm study, the effectiveness of LDD in combination with non-surgical periodontal therapy on gingival crevicular fluid (GCF) Ln-5 γ2 chain fragment levels and clinical parameters in patients with chronic periodontitis was examined over a 12-month period.","downloadable_attachments":[{"id":44323604,"asset_id":14319811,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33273345,"first_name":"Gül","last_name":"Atilla","domain_name":"ege","page_name":"GülAtilla","display_name":"Gül Atilla","profile_url":"https://ege.academia.edu/G%C3%BClAtilla?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=137516","nofollow":true},{"id":50515,"name":"Periodontology","url":"https://www.academia.edu/Documents/in/Periodontology?f_ri=137516","nofollow":true},{"id":72821,"name":"Low Dose","url":"https://www.academia.edu/Documents/in/Low_Dose?f_ri=137516","nofollow":true},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":158052,"name":"Placebos","url":"https://www.academia.edu/Documents/in/Placebos?f_ri=137516"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents?f_ri=137516"},{"id":521903,"name":"Doxycycline","url":"https://www.academia.edu/Documents/in/Doxycycline?f_ri=137516"},{"id":552210,"name":"Periodontitis","url":"https://www.academia.edu/Documents/in/Periodontitis?f_ri=137516"},{"id":584598,"name":"Dental Plaque Index","url":"https://www.academia.edu/Documents/in/Dental_Plaque_Index?f_ri=137516"},{"id":724446,"name":"Gingival Crevicular Fluid","url":"https://www.academia.edu/Documents/in/Gingival_Crevicular_Fluid?f_ri=137516"},{"id":855633,"name":"Chronic Periodontitis","url":"https://www.academia.edu/Documents/in/Chronic_Periodontitis?f_ri=137516"},{"id":2139917,"name":"Dental Scaling","url":"https://www.academia.edu/Documents/in/Dental_Scaling?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14370365" data-work_id="14370365" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14370365/Reimplantation_of_the_right_internal_thoracic_artery_as_a_free_graft_into_the_left_in_situ_internal_thoracic_artery_Y_Procedure_One_year_angiographic_results">Reimplantation of the right internal thoracic artery as a free graft into the left in situ internal thoracic artery (Y Procedure): One-year angiographic results</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Reimplantation of the right internal thoracic artery, as a free graft, into the left in situ internal thoracic artery (Y procedure) has enabled us to bypass more distant marginal vessels, which was not possible by the bilateral technique... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14370365" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Reimplantation of the right internal thoracic artery, as a free graft, into the left in situ internal thoracic artery (Y procedure) has enabled us to bypass more distant marginal vessels, which was not possible by the bilateral technique alone. This prospective study was aimed at evaluating the clinical state of the patients and the degree of patency of grafts within 16 months of follow-up. All 80 patients who underwent the Y procedure between January 1988 and January 1992 were included. This group represented 10% of the 840 patients having coronary bypass during the same period. A total of 202 coronary anastomoses were performed in this series. Early postoperative (30 days) complications included three deaths (3.75%), eight myocardial infarctions (10%), one case of phrenic nerve paralysis (1.25%), two cases of respiratory failure (2.5%), and six wound infections (7.5%). At 3 months' follow-up, 96% of patients were free of symptoms. During the follow-up period, four patients died of noncardiac causes (lung, pancreatic, and brain cancer and rupture of an abdominal aortic aneurysm). At 1 year, 71 patients were free of symptoms (97%). Sixty-one patients underwent coronary angiography between 12 and 24 months. Six patients with peripheral arterial disease were not suitable for coronary angiography, and six refused to be tested. These 12 patients had normal thallium test results in the bypassed area (stress or dipyridamole test). The patency rate of the left internal thoracic artery was 98.3% (n = 60), occlusion rate 1.6% (n = 1), and incidence of threadlike arteries 4.9% (n = 3). Thus the rate of perfect patency was 93.4%. The patency rate of the right internal thoracic artery as a free graft was 93.4% (n = 57), occlusion rate 6.5% (n = 4), and the incidence of threadlike arteries 8% (n = 5). Thus the rate of perfect patency was 85.2%. A total of 169 anastomoses were studied. The rate of patency of the anastomoses to the left anterior descending coronary artery was 96% (n = 58) and the occlusion rate, 4% (n = 2). The patency rate of sequential anastomoses (side to side) to diagonal arteries was 100% (n = 16). Patency rate of anastomoses to obtuse marginal arteries was 95% (n = 58) and the rate of occlusion, 4.9% (n = 3). The patency rate of anastomoses to the posterior descending artery or distal branches of the right coronary artery was 80% (n = 4/5). We conclude that the Y procedure is a ~safe technique with an acceptable morbidity and a good patency rate. This procedure can be used when the in situ technique is not possible because of far-reaching distal marginal coronary arteries. (J THORAC CARDIOVASC SURG 1995;109:1042-8)</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14370365" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d171a412e214b6d0e8c073107b097db1" rel="nofollow" data-download="{"attachment_id":44275349,"asset_id":14370365,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44275349/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33313310" href="https://univ-brest.academia.edu/JacquesMansourati">Jacques Mansourati</a><script data-card-contents-for-user="33313310" type="text/json">{"id":33313310,"first_name":"Jacques","last_name":"Mansourati","domain_name":"univ-brest","page_name":"JacquesMansourati","display_name":"Jacques Mansourati","profile_url":"https://univ-brest.academia.edu/JacquesMansourati?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14370365 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14370365"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14370365, container: ".js-paper-rank-work_14370365", }); 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$(".js-view-count[data-work-id=14370365]").text(description); $(".js-view-count-work_14370365").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14370365").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14370365"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">15</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a>, <script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="167876" rel="nofollow" href="https://www.academia.edu/Documents/in/Myocardial_Revascularization">Myocardial Revascularization</a>, <script data-card-contents-for-ri="167876" type="text/json">{"id":167876,"name":"Myocardial Revascularization","url":"https://www.academia.edu/Documents/in/Myocardial_Revascularization?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="222776" rel="nofollow" href="https://www.academia.edu/Documents/in/Respiratory_Failure">Respiratory Failure</a><script data-card-contents-for-ri="222776" type="text/json">{"id":222776,"name":"Respiratory Failure","url":"https://www.academia.edu/Documents/in/Respiratory_Failure?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14370365]'), work: {"id":14370365,"title":"Reimplantation of the right internal thoracic artery as a free graft into the left in situ internal thoracic artery (Y Procedure): One-year angiographic results","created_at":"2015-07-24T11:11:17.108-07:00","url":"https://www.academia.edu/14370365/Reimplantation_of_the_right_internal_thoracic_artery_as_a_free_graft_into_the_left_in_situ_internal_thoracic_artery_Y_Procedure_One_year_angiographic_results?f_ri=137516","dom_id":"work_14370365","summary":"Reimplantation of the right internal thoracic artery, as a free graft, into the left in situ internal thoracic artery (Y procedure) has enabled us to bypass more distant marginal vessels, which was not possible by the bilateral technique alone. This prospective study was aimed at evaluating the clinical state of the patients and the degree of patency of grafts within 16 months of follow-up. All 80 patients who underwent the Y procedure between January 1988 and January 1992 were included. This group represented 10% of the 840 patients having coronary bypass during the same period. A total of 202 coronary anastomoses were performed in this series. Early postoperative (30 days) complications included three deaths (3.75%), eight myocardial infarctions (10%), one case of phrenic nerve paralysis (1.25%), two cases of respiratory failure (2.5%), and six wound infections (7.5%). At 3 months' follow-up, 96% of patients were free of symptoms. During the follow-up period, four patients died of noncardiac causes (lung, pancreatic, and brain cancer and rupture of an abdominal aortic aneurysm). At 1 year, 71 patients were free of symptoms (97%). Sixty-one patients underwent coronary angiography between 12 and 24 months. Six patients with peripheral arterial disease were not suitable for coronary angiography, and six refused to be tested. These 12 patients had normal thallium test results in the bypassed area (stress or dipyridamole test). The patency rate of the left internal thoracic artery was 98.3% (n = 60), occlusion rate 1.6% (n = 1), and incidence of threadlike arteries 4.9% (n = 3). Thus the rate of perfect patency was 93.4%. The patency rate of the right internal thoracic artery as a free graft was 93.4% (n = 57), occlusion rate 6.5% (n = 4), and the incidence of threadlike arteries 8% (n = 5). Thus the rate of perfect patency was 85.2%. A total of 169 anastomoses were studied. The rate of patency of the anastomoses to the left anterior descending coronary artery was 96% (n = 58) and the occlusion rate, 4% (n = 2). The patency rate of sequential anastomoses (side to side) to diagonal arteries was 100% (n = 16). Patency rate of anastomoses to obtuse marginal arteries was 95% (n = 58) and the rate of occlusion, 4.9% (n = 3). The patency rate of anastomoses to the posterior descending artery or distal branches of the right coronary artery was 80% (n = 4/5). We conclude that the Y procedure is a ~safe technique with an acceptable morbidity and a good patency rate. This procedure can be used when the in situ technique is not possible because of far-reaching distal marginal coronary arteries. (J THORAC CARDIOVASC SURG 1995;109:1042-8)","downloadable_attachments":[{"id":44275349,"asset_id":14370365,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33313310,"first_name":"Jacques","last_name":"Mansourati","domain_name":"univ-brest","page_name":"JacquesMansourati","display_name":"Jacques Mansourati","profile_url":"https://univ-brest.academia.edu/JacquesMansourati?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":167876,"name":"Myocardial Revascularization","url":"https://www.academia.edu/Documents/in/Myocardial_Revascularization?f_ri=137516","nofollow":true},{"id":222776,"name":"Respiratory Failure","url":"https://www.academia.edu/Documents/in/Respiratory_Failure?f_ri=137516","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=137516"},{"id":374984,"name":"Coronary Angiography","url":"https://www.academia.edu/Documents/in/Coronary_Angiography?f_ri=137516"},{"id":398808,"name":"Coronary heart disease","url":"https://www.academia.edu/Documents/in/Coronary_heart_disease?f_ri=137516"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=137516"},{"id":789977,"name":"Coronary Artery Disease","url":"https://www.academia.edu/Documents/in/Coronary_Artery_Disease?f_ri=137516"},{"id":1305425,"name":"Abdominal Aortic Aneurysm","url":"https://www.academia.edu/Documents/in/Abdominal_Aortic_Aneurysm?f_ri=137516"},{"id":1312754,"name":"Prospective Study","url":"https://www.academia.edu/Documents/in/Prospective_Study?f_ri=137516"},{"id":1831343,"name":"Peripheral artery disease","url":"https://www.academia.edu/Documents/in/Peripheral_artery_disease?f_ri=137516"},{"id":1883354,"name":"Thoracic and cardiovascular surgery","url":"https://www.academia.edu/Documents/in/Thoracic_and_cardiovascular_surgery?f_ri=137516"},{"id":2356404,"name":"Coronary artery","url":"https://www.academia.edu/Documents/in/Coronary_artery?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10254377" data-work_id="10254377" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10254377/Metastatic_Eccrine_Porocarcinoma_A_5_6Year_Follow_up_Study_of_a_Patient_Treated_With_a_Combined_Therapeutic_Protocol">Metastatic Eccrine Porocarcinoma: A 5.6Year Follow-up Study of a Patient Treated With a Combined Therapeutic Protocol</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background. Metastatic eccrine porocarcinoma (EP) is an uncommon, malignant, and potentially lethal neoplasm that arises from the eccrine sweat glands.Objective. To present the 5.6-year follow-up study of a male patient with metastatic... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10254377" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background. Metastatic eccrine porocarcinoma (EP) is an uncommon, malignant, and potentially lethal neoplasm that arises from the eccrine sweat glands.Objective. To present the 5.6-year follow-up study of a male patient with metastatic EP, highlighting the widespread cutaneous involvement and the response to the treatment carried out.Methods. We describe the evolution of the tumor and the combined therapy carried out and review the treatments employed in previously reported cases, comparing them with ours.Results. The patient developed multiple cutaneous and regional lymph node metastases 15 months after surgical excision of the primary tumor. He was treated with prophylactic lymphadenectomy, radiotherapy, and oral isotretinoin, subsequently substituted by tegafur. We have not found evidence of distant metastases after a 5.6-year follow-up.Conclusions. The optimum treatment for metastatic EP is not standardized, and the results obtained to date were generally poor. In this context, we consider it of interest to highlight the response of our patient to the therapeutic regime employed, which may be advantageous in future cases of this rare tumor.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10254377" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="74cc1957360b7f2b4326615dfe994441" rel="nofollow" data-download="{"attachment_id":47466935,"asset_id":10254377,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47466935/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="25103048" href="https://independent.academia.edu/santiagogomez20">santiago gomez</a><script data-card-contents-for-user="25103048" type="text/json">{"id":25103048,"first_name":"santiago","last_name":"gomez","domain_name":"independent","page_name":"santiagogomez20","display_name":"santiago gomez","profile_url":"https://independent.academia.edu/santiagogomez20?f_ri=137516","photo":"https://0.academia-photos.com/25103048/22834003/21988332/s65_santiago.gomez.jpg"}</script></span></span></li><li class="js-paper-rank-work_10254377 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10254377"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10254377, container: ".js-paper-rank-work_10254377", }); });</script></li><li class="js-percentile-work_10254377 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 10254377; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_10254377"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_10254377 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="10254377"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 10254377; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=10254377]").text(description); $(".js-view-count-work_10254377").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_10254377").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="10254377"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">6</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a>, <script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="289271" rel="nofollow" href="https://www.academia.edu/Documents/in/Aged">Aged</a>, <script data-card-contents-for-ri="289271" type="text/json">{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="413195" rel="nofollow" href="https://www.academia.edu/Documents/in/Time_Factors">Time Factors</a><script data-card-contents-for-ri="413195" type="text/json">{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=10254377]'), work: {"id":10254377,"title":"Metastatic Eccrine Porocarcinoma: A 5.6Year Follow-up Study of a Patient Treated With a Combined Therapeutic Protocol","created_at":"2015-01-20T18:31:49.428-08:00","url":"https://www.academia.edu/10254377/Metastatic_Eccrine_Porocarcinoma_A_5_6Year_Follow_up_Study_of_a_Patient_Treated_With_a_Combined_Therapeutic_Protocol?f_ri=137516","dom_id":"work_10254377","summary":"Background. Metastatic eccrine porocarcinoma (EP) is an uncommon, malignant, and potentially lethal neoplasm that arises from the eccrine sweat glands.Objective. To present the 5.6-year follow-up study of a male patient with metastatic EP, highlighting the widespread cutaneous involvement and the response to the treatment carried out.Methods. We describe the evolution of the tumor and the combined therapy carried out and review the treatments employed in previously reported cases, comparing them with ours.Results. The patient developed multiple cutaneous and regional lymph node metastases 15 months after surgical excision of the primary tumor. He was treated with prophylactic lymphadenectomy, radiotherapy, and oral isotretinoin, subsequently substituted by tegafur. We have not found evidence of distant metastases after a 5.6-year follow-up.Conclusions. The optimum treatment for metastatic EP is not standardized, and the results obtained to date were generally poor. In this context, we consider it of interest to highlight the response of our patient to the therapeutic regime employed, which may be advantageous in future cases of this rare tumor.","downloadable_attachments":[{"id":47466935,"asset_id":10254377,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":25103048,"first_name":"santiago","last_name":"gomez","domain_name":"independent","page_name":"santiagogomez20","display_name":"santiago gomez","profile_url":"https://independent.academia.edu/santiagogomez20?f_ri=137516","photo":"https://0.academia-photos.com/25103048/22834003/21988332/s65_santiago.gomez.jpg"}],"research_interests":[{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516","nofollow":true},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=137516","nofollow":true},{"id":897058,"name":"Dermatologic Surgery","url":"https://www.academia.edu/Documents/in/Dermatologic_Surgery?f_ri=137516"},{"id":2463779,"name":"Combined Modality Therapy","url":"https://www.academia.edu/Documents/in/Combined_Modality_Therapy?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13648865 coauthored" data-work_id="13648865" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13648865/Minimal_Access_Cranial_Suspension_Lift_A_Modified_S_Lift">Minimal Access Cranial Suspension Lift: A Modified S-Lift</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">There is a strong trend at hand toward less dramatic facial rejuvenation surgery. Most of the authors' patients want a cosmetic improvement but not at the cost of prolonged disfigurement or a high risk of complications. In 1999, a very... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13648865" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">There is a strong trend at hand toward less dramatic facial rejuvenation surgery. Most of the authors' patients want a cosmetic improvement but not at the cost of prolonged disfigurement or a high risk of complications. In 1999, a very simple but effective rhytidectomy technique, termed an S-lift, was described in the literature and was adopted by the authors. Its basic principle is the suspension of sagging facial features by a strong, permanent purse-string suture. The procedure is performed with the patient under local anesthesia. Significant modifications were applied to the incision, to the purse-string suture anchoring site, and to the direction and shape of the skin excision. The authors named the modified procedure the minimal access cranial suspension lift to specifically describe the concept of the technique. Through an inverted L-shaped preauricular incision with extension below the sideburn, a limited skin undermining is performed. Two strong, permanent purse-string sutures are woven into the superficial musculoaponeurotic system tissues in a vertical U and an oblique O shape, initiating from a strong anchorage in the deep temporal fascia at the level of the helical crus. Tying these sutures produces a very powerful vertical correction of descended facial features that acts mainly on the jowls and the upper neck. The procedure can be extended by continuing the dissection over the malar fat pad, placing a third vertical purse-string suture with strong action on the nasolabial groove, and vertically repositioning the midfacial volumes. During 20 months, pleasing results and a very low complication rate were obtained in 88 consecutive patients with a mean age of 55 1 ⁄2 years. In this article, the authors provide a detailed description of the anesthetic and surgical technique, a demonstration of the results in different patient age categories, and a discussion comparing the minimal access cranial suspension lift with other types of facial rejuvenation procedures. (Plast. Reconstr. Surg. 109:</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13648865" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bbed76d6fae64c69dc7f668fdc752df6" rel="nofollow" data-download="{"attachment_id":45109006,"asset_id":13648865,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45109006/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32805128" href="https://ugent.academia.edu/KVanLanduyt">K. Van Landuyt</a><script data-card-contents-for-user="32805128" type="text/json">{"id":32805128,"first_name":"K. Van","last_name":"Landuyt","domain_name":"ugent","page_name":"KVanLanduyt","display_name":"K. 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Most of the authors' patients want a cosmetic improvement but not at the cost of prolonged disfigurement or a high risk of complications. In 1999, a very simple but effective rhytidectomy technique, termed an S-lift, was described in the literature and was adopted by the authors. Its basic principle is the suspension of sagging facial features by a strong, permanent purse-string suture. The procedure is performed with the patient under local anesthesia. Significant modifications were applied to the incision, to the purse-string suture anchoring site, and to the direction and shape of the skin excision. The authors named the modified procedure the minimal access cranial suspension lift to specifically describe the concept of the technique. Through an inverted L-shaped preauricular incision with extension below the sideburn, a limited skin undermining is performed. Two strong, permanent purse-string sutures are woven into the superficial musculoaponeurotic system tissues in a vertical U and an oblique O shape, initiating from a strong anchorage in the deep temporal fascia at the level of the helical crus. Tying these sutures produces a very powerful vertical correction of descended facial features that acts mainly on the jowls and the upper neck. The procedure can be extended by continuing the dissection over the malar fat pad, placing a third vertical purse-string suture with strong action on the nasolabial groove, and vertically repositioning the midfacial volumes. During 20 months, pleasing results and a very low complication rate were obtained in 88 consecutive patients with a mean age of 55 1 ⁄2 years. In this article, the authors provide a detailed description of the anesthetic and surgical technique, a demonstration of the results in different patient age categories, and a discussion comparing the minimal access cranial suspension lift with other types of facial rejuvenation procedures. (Plast. Reconstr. Surg. 109:","downloadable_attachments":[{"id":45109006,"asset_id":13648865,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32805128,"first_name":"K. Van","last_name":"Landuyt","domain_name":"ugent","page_name":"KVanLanduyt","display_name":"K. Van Landuyt","profile_url":"https://ugent.academia.edu/KVanLanduyt?f_ri=137516","photo":"/images/s65_no_pic.png"},{"id":33082339,"first_name":"Alexis","last_name":"Verpaele","domain_name":"vub","page_name":"AlexisVerpaele","display_name":"Alexis Verpaele","profile_url":"https://vub.academia.edu/AlexisVerpaele?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":51195,"name":"Esthetics","url":"https://www.academia.edu/Documents/in/Esthetics?f_ri=137516","nofollow":true},{"id":53714,"name":"Plastic and Reconstructive Surgery","url":"https://www.academia.edu/Documents/in/Plastic_and_Reconstructive_Surgery?f_ri=137516","nofollow":true},{"id":130538,"name":"Plastic","url":"https://www.academia.edu/Documents/in/Plastic?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":210781,"name":"Dental Local Anesthesia","url":"https://www.academia.edu/Documents/in/Dental_Local_Anesthesia?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19527214" data-work_id="19527214" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19527214/Assessing_the_Long_Term_Effects_of_EMDR_Results_from_an_18_Month_Follow_Up_Study_with_Adult_Female_Survivors_of_CSA">Assessing the Long-Term Effects of EMDR: Results from an 18-Month Follow-Up Study with Adult Female Survivors of CSA</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">This 18-month follow-up study builds on the findings of a randomized experimental evaluation that found qualified support for He has authored or coauthored over 100 publications, most of which deal with research methods or with empirical... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_19527214" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This 18-month follow-up study builds on the findings of a randomized experimental evaluation that found qualified support for He has authored or coauthored over 100 publications, most of which deal with research methods or with empirical evaluations of practice in such areas as domestic violence, severe and persistent mental illness, the assessment and treatment of traumatized children, engagement and retention in substance abuse treatment programs, and the effectiveness of eye movement desensitization and reprocessing (EMDR).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19527214" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="551e0daf0ca387cb1b138650d53329c0" rel="nofollow" data-download="{"attachment_id":40673594,"asset_id":19527214,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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the findings of a randomized experimental evaluation that found qualified support for He has authored or coauthored over 100 publications, most of which deal with research methods or with empirical evaluations of practice in such areas as domestic violence, severe and persistent mental illness, the assessment and treatment of traumatized children, engagement and retention in substance abuse treatment programs, and the effectiveness of eye movement desensitization and reprocessing (EMDR).","downloadable_attachments":[{"id":40673594,"asset_id":19527214,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39830396,"first_name":"Tonya","last_name":"Edmond","domain_name":"independent","page_name":"TonyaEdmond","display_name":"Tonya Edmond","profile_url":"https://independent.academia.edu/TonyaEdmond?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=137516","nofollow":true},{"id":940,"name":"Social Work","url":"https://www.academia.edu/Documents/in/Social_Work?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":55577,"name":"Survival","url":"https://www.academia.edu/Documents/in/Survival?f_ri=137516","nofollow":true},{"id":60356,"name":"Childhood Sexual Abuse","url":"https://www.academia.edu/Documents/in/Childhood_Sexual_Abuse?f_ri=137516"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=137516"},{"id":73740,"name":"Child Sexual 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patient satisfaction after implantation of an aspheric apodized diffractive intraocular lens (IOL) or a spherical apodized diffractive IOL in cataract surgery.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20132238" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a8b720784811132621b8620dacca432a" rel="nofollow" data-download="{"attachment_id":41217805,"asset_id":20132238,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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href="https://www.academia.edu/4138813/Duct_to_duct_biliary_reconstruction_in_right_lobe_adult_living_donor_liver_transplantation_1_1_No_competing_interest_declared">Duct-to-duct biliary reconstruction in right lobe adult living donor liver transplantation 1 1 No competing interest declared</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4138813" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="896bfc4a7085439d2a7fe37b8db4bf36" rel="nofollow" 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itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/49967840/Investigation_of_a_reinforcement_based_toilet_training_procedure_for_children_with_autism">Investigation of a reinforcement-based toilet training procedure for children with autism</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Independent toileting is an important developmental skill which individuals with developmental disabilities often ®nd a challenge to master. Effective toilet training interventions have been designed which rely on a combination of basic... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_49967840" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Independent toileting is an important developmental skill which individuals with developmental disabilities often ®nd a challenge to master. Effective toilet training interventions have been designed which rely on a combination of basic operant principles of positive reinforcement and punishment. In the present study, the effectiveness of a reinforcement-based toilet training intervention was investigated with three children with a diagnosis of autism. Procedures included a combination of positive reinforcement, graduated guidance, scheduled practice trials and forward prompting. Results indicated that all procedures were implemented in response to urination accidents. A three participants reduced urination accidents to zero and learned to spontaneously request use of the bathroom within 7±11 days of training. Gains were maintained over 6-month and 1-year follow-ups. Findings suggest that the proposed procedure is an effective and rapid method of toilet training, which can be implemented within a structured school setting with generalization to the home environment.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/49967840" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3d54e8dc8d15a68c062cc621a052d792" rel="nofollow" data-download="{"attachment_id":68127524,"asset_id":49967840,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/68127524/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="183629603" href="https://independent.academia.edu/AlbertPfadt">Albert Pfadt</a><script data-card-contents-for-user="183629603" type="text/json">{"id":183629603,"first_name":"Albert","last_name":"Pfadt","domain_name":"independent","page_name":"AlbertPfadt","display_name":"Albert Pfadt","profile_url":"https://independent.academia.edu/AlbertPfadt?f_ri=137516","photo":"https://gravatar.com/avatar/d324094c6ec36ffc45475a3d06d0936a?s=65"}</script></span></span></li><li class="js-paper-rank-work_49967840 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="49967840"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 49967840, container: ".js-paper-rank-work_49967840", }); 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Effective toilet training interventions have been designed which rely on a combination of basic operant principles of positive reinforcement and punishment. In the present study, the effectiveness of a reinforcement-based toilet training intervention was investigated with three children with a diagnosis of autism. Procedures included a combination of positive reinforcement, graduated guidance, scheduled practice trials and forward prompting. Results indicated that all procedures were implemented in response to urination accidents. A three participants reduced urination accidents to zero and learned to spontaneously request use of the bathroom within 7±11 days of training. Gains were maintained over 6-month and 1-year follow-ups. Findings suggest that the proposed procedure is an effective and rapid method of toilet training, which can be implemented within a structured school setting with generalization to the home environment.","downloadable_attachments":[{"id":68127524,"asset_id":49967840,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":183629603,"first_name":"Albert","last_name":"Pfadt","domain_name":"independent","page_name":"AlbertPfadt","display_name":"Albert Pfadt","profile_url":"https://independent.academia.edu/AlbertPfadt?f_ri=137516","photo":"https://gravatar.com/avatar/d324094c6ec36ffc45475a3d06d0936a?s=65"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=137516","nofollow":true},{"id":1062,"name":"Special Education","url":"https://www.academia.edu/Documents/in/Special_Education?f_ri=137516","nofollow":true},{"id":1317,"name":"Behavior Modification","url":"https://www.academia.edu/Documents/in/Behavior_Modification?f_ri=137516","nofollow":true},{"id":2249,"name":"Autism","url":"https://www.academia.edu/Documents/in/Autism?f_ri=137516","nofollow":true},{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment?f_ri=137516"},{"id":14197,"name":"Autonomy","url":"https://www.academia.edu/Documents/in/Autonomy?f_ri=137516"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=137516"},{"id":137145,"name":"Developmental disabilities","url":"https://www.academia.edu/Documents/in/Developmental_disabilities?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":140420,"name":"Token Economy","url":"https://www.academia.edu/Documents/in/Token_Economy?f_ri=137516"},{"id":145286,"name":"Reinforcement","url":"https://www.academia.edu/Documents/in/Reinforcement?f_ri=137516"},{"id":201203,"name":"Hygiene","url":"https://www.academia.edu/Documents/in/Hygiene?f_ri=137516"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=137516"},{"id":1208706,"name":"Environment","url":"https://www.academia.edu/Documents/in/Environment?f_ri=137516"},{"id":1929419,"name":"Nino","url":"https://www.academia.edu/Documents/in/Nino?f_ri=137516"},{"id":2489699,"name":"Autistic disorder","url":"https://www.academia.edu/Documents/in/Autistic_disorder?f_ri=137516"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div 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class="u-tcGrayDark u-fw700" data-has-card-for-user="43511920" href="https://independent.academia.edu/PMassin">Philippe Massin</a><script data-card-contents-for-user="43511920" type="text/json">{"id":43511920,"first_name":"Philippe","last_name":"Massin","domain_name":"independent","page_name":"PMassin","display_name":"Philippe Massin","profile_url":"https://independent.academia.edu/PMassin?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22162388 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22162388"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22162388, container: ".js-paper-rank-work_22162388", }); });</script></li><li class="js-percentile-work_22162388 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget 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$(".js-view-count[data-work-id=22162388]").text(description); $(".js-view-count-work_22162388").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_22162388").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="22162388"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">12</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="588" rel="nofollow" href="https://www.academia.edu/Documents/in/Nursing">Nursing</a>, <script data-card-contents-for-ri="588" type="text/json">{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="80562" rel="nofollow" href="https://www.academia.edu/Documents/in/Injury">Injury</a><script data-card-contents-for-ri="80562" type="text/json">{"id":80562,"name":"Injury","url":"https://www.academia.edu/Documents/in/Injury?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22162388]'), work: {"id":22162388,"title":"Treatment of complex fractures of the distal radius: A prospective randomised comparison of external fixation ‘versus’ locked volar plating","created_at":"2016-02-18T22:36:18.300-08:00","url":"https://www.academia.edu/22162388/Treatment_of_complex_fractures_of_the_distal_radius_A_prospective_randomised_comparison_of_external_fixation_versus_locked_volar_plating?f_ri=137516","dom_id":"work_22162388","summary":null,"downloadable_attachments":[{"id":42825215,"asset_id":22162388,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43511920,"first_name":"Philippe","last_name":"Massin","domain_name":"independent","page_name":"PMassin","display_name":"Philippe Massin","profile_url":"https://independent.academia.edu/PMassin?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=137516","nofollow":true},{"id":80562,"name":"Injury","url":"https://www.academia.edu/Documents/in/Injury?f_ri=137516","nofollow":true},{"id":125564,"name":"Statistical Significance","url":"https://www.academia.edu/Documents/in/Statistical_Significance?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=137516"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=137516"},{"id":1142792,"name":"Fracture Fixation","url":"https://www.academia.edu/Documents/in/Fracture_Fixation?f_ri=137516"},{"id":1312233,"name":"External Fixators","url":"https://www.academia.edu/Documents/in/External_Fixators?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_12946911 coauthored" data-work_id="12946911" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12946911/Assessment_of_adrenoleukodystrophy_lesions_by_high_field_MRS_in_non_sedated_pediatric_patients">Assessment of adrenoleukodystrophy lesions by high field MRS in non-sedated pediatric patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Early detection of white matter lesions in childhood-onset cerebral adrenoleukodystrophy (ALD) is important as hematopoietic cell transplantation (HCT), currently the only effective treatment, is beneficial only if performed... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_12946911" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Early detection of white matter lesions in childhood-onset cerebral adrenoleukodystrophy (ALD) is important as hematopoietic cell transplantation (HCT), currently the only effective treatment, is beneficial only if performed early in the disease course. Objective: To establish reliable biochemical markers of cerebral disease progression in patients with ALD to aid in treatment planning. Methods: The authors used proton magnetic resonance spectroscopy (MRS) in combination with LCModel analysis to quantify brain metabolites in small volumes (3 to 16 mL) in the occipital and frontal white matter and the splenium of the corpus callosum of 17 unsedated patients and 26 healthy volunteers (adult n ϭ 21, age-matched n ϭ 5) at 4 tesla. Results: Absolute concentrations of 12 metabolites were reliably determined, seven of which were established as markers of lesion development. Among these, creatine and choline containing compounds were the weakest markers while N-acetylaspartate, glutamine, and lipids ϩ lactate were the strongest. The large extent of changes in the markers enabled detection of early neurochemical changes in lesion formation prior to detection of abnormalities by conventional MRI. Concentrations of a number of metabolites were also significantly different between normal appearing white matter of patients and controls indicating biochemical alterations in the absence of cerebral disease. Neurochemical improvements following HCT were measured in six patients. Conclusions: The progression of adrenoleukodystrophy, as well as effectiveness of its treatment, can be assessed with high precision using high field 1 H magnetic resonance spectroscopy in individual patients without the need for sedation. balt4/znl-neurol/znl-neurol/znl00305/znl9349-05a simmsl S8؍ 12/8/</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/12946911" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="784bdb27059a514485c3123f7e5956ac" rel="nofollow" data-download="{"attachment_id":45830949,"asset_id":12946911,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45830949/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43479245" href="https://kumc.academia.edu/InYoungChoi">In-Young Choi</a><script data-card-contents-for-user="43479245" type="text/json">{"id":43479245,"first_name":"In-Young","last_name":"Choi","domain_name":"kumc","page_name":"InYoungChoi","display_name":"In-Young Choi","profile_url":"https://kumc.academia.edu/InYoungChoi?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-12946911">+2</span><div class="hidden js-additional-users-12946911"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://spanalumni.academia.edu/G%C3%BClin%C3%96z">Gülin Öz</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://umn.academia.edu/IvanTk%C3%A1%C4%8D">Ivan Tkáč</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-12946911'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-12946911').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_12946911 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="12946911"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12946911; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12946911]").text(description); $(".js-view-count-work_12946911").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_12946911").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="12946911"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">17</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="623" rel="nofollow" href="https://www.academia.edu/Documents/in/Neurology">Neurology</a>, <script data-card-contents-for-ri="623" type="text/json">{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="13777" rel="nofollow" href="https://www.academia.edu/Documents/in/Creatine">Creatine</a>, <script data-card-contents-for-ri="13777" type="text/json">{"id":13777,"name":"Creatine","url":"https://www.academia.edu/Documents/in/Creatine?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="21732" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy">Magnetic Resonance Spectroscopy</a><script data-card-contents-for-ri="21732" type="text/json">{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=12946911]'), work: {"id":12946911,"title":"Assessment of adrenoleukodystrophy lesions by high field MRS in non-sedated pediatric patients","created_at":"2015-06-12T07:59:27.875-07:00","url":"https://www.academia.edu/12946911/Assessment_of_adrenoleukodystrophy_lesions_by_high_field_MRS_in_non_sedated_pediatric_patients?f_ri=137516","dom_id":"work_12946911","summary":"Background: Early detection of white matter lesions in childhood-onset cerebral adrenoleukodystrophy (ALD) is important as hematopoietic cell transplantation (HCT), currently the only effective treatment, is beneficial only if performed early in the disease course. Objective: To establish reliable biochemical markers of cerebral disease progression in patients with ALD to aid in treatment planning. Methods: The authors used proton magnetic resonance spectroscopy (MRS) in combination with LCModel analysis to quantify brain metabolites in small volumes (3 to 16 mL) in the occipital and frontal white matter and the splenium of the corpus callosum of 17 unsedated patients and 26 healthy volunteers (adult n ϭ 21, age-matched n ϭ 5) at 4 tesla. Results: Absolute concentrations of 12 metabolites were reliably determined, seven of which were established as markers of lesion development. Among these, creatine and choline containing compounds were the weakest markers while N-acetylaspartate, glutamine, and lipids ϩ lactate were the strongest. The large extent of changes in the markers enabled detection of early neurochemical changes in lesion formation prior to detection of abnormalities by conventional MRI. Concentrations of a number of metabolites were also significantly different between normal appearing white matter of patients and controls indicating biochemical alterations in the absence of cerebral disease. Neurochemical improvements following HCT were measured in six patients. Conclusions: The progression of adrenoleukodystrophy, as well as effectiveness of its treatment, can be assessed with high precision using high field 1 H magnetic resonance spectroscopy in individual patients without the need for sedation. balt4/znl-neurol/znl-neurol/znl00305/znl9349-05a simmsl S8؍ 12/8/","downloadable_attachments":[{"id":45830949,"asset_id":12946911,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43479245,"first_name":"In-Young","last_name":"Choi","domain_name":"kumc","page_name":"InYoungChoi","display_name":"In-Young Choi","profile_url":"https://kumc.academia.edu/InYoungChoi?f_ri=137516","photo":"/images/s65_no_pic.png"},{"id":32131600,"first_name":"Gülin","last_name":"Öz","domain_name":"spanalumni","page_name":"GülinÖz","display_name":"Gülin Öz","profile_url":"https://spanalumni.academia.edu/G%C3%BClin%C3%96z?f_ri=137516","photo":"/images/s65_no_pic.png"},{"id":32179340,"first_name":"Ivan","last_name":"Tkáč","domain_name":"umn","page_name":"IvanTkáč","display_name":"Ivan Tkáč","profile_url":"https://umn.academia.edu/IvanTk%C3%A1%C4%8D?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=137516","nofollow":true},{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=137516","nofollow":true},{"id":13777,"name":"Creatine","url":"https://www.academia.edu/Documents/in/Creatine?f_ri=137516","nofollow":true},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy?f_ri=137516","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=137516"},{"id":52055,"name":"Lipids","url":"https://www.academia.edu/Documents/in/Lipids?f_ri=137516"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":168638,"name":"Inositol","url":"https://www.academia.edu/Documents/in/Inositol?f_ri=137516"},{"id":180631,"name":"D-Aspartic Acid","url":"https://www.academia.edu/Documents/in/D-Aspartic_Acid?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":382341,"name":"Glutamine","url":"https://www.academia.edu/Documents/in/Glutamine?f_ri=137516"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=137516"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=137516"},{"id":981291,"name":"Brain Chemistry","url":"https://www.academia.edu/Documents/in/Brain_Chemistry?f_ri=137516"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=137516"},{"id":2374838,"name":"Hematopoietic Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell_Transplantation?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_25950071" data-work_id="25950071" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25950071/Adhesively_restored_anterior_maxillary_dentitions_affected_by_severe_erosion_up_to_6_year_results_of_a_prospective_clinical_study">Adhesively restored anterior maxillary dentitions affected by severe erosion: up to 6-year results of a prospective clinical study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">In case of severe dental erosion, the maxillary anterior teeth are often particularly affected. Restoring such teeth conventionally (ie, crowns) would frequently involve elective endodontic therapy and major additional loss of tooth... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_25950071" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In case of severe dental erosion, the maxillary anterior teeth are often particularly affected. Restoring such teeth conventionally (ie, crowns) would frequently involve elective endodontic therapy and major additional loss of tooth structure. A novel, minimally invasive approach to restore eroded teeth has been developed and is currently being tested in the form of a prospective clinical trial, termed The Geneva Erosion Study. To avoid crowns, two separate veneers with different paths of insertion have been used to restore the affected anterior maxillary teeth, regardless of clinical crown length and amount of remaining enamel. This treatment is called The Sandwich Approach. The purpose of this case series study was to analyze the mid-term clinical outcome of maxillary anterior teeth affected by severe dental erosion that were restored following the Sandwich Approach. Twelve consecutively consulting patients (mean age: 39.4 years) suffering from advanced dental erosion have been en...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25950071" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c8d87cd2d567cda84731dc4a2d04f021" rel="nofollow" data-download="{"attachment_id":46304536,"asset_id":25950071,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46304536/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="49712087" href="https://gfri.academia.edu/LindaGr%C3%BCtter">Linda Grütter</a><script data-card-contents-for-user="49712087" type="text/json">{"id":49712087,"first_name":"Linda","last_name":"Grütter","domain_name":"gfri","page_name":"LindaGrütter","display_name":"Linda Grütter","profile_url":"https://gfri.academia.edu/LindaGr%C3%BCtter?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_25950071 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25950071"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25950071, container: ".js-paper-rank-work_25950071", }); 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$(".js-view-count[data-work-id=25950071]").text(description); $(".js-view-count-work_25950071").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_25950071").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="25950071"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">17</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="596" rel="nofollow" href="https://www.academia.edu/Documents/in/Dentistry">Dentistry</a>, <script data-card-contents-for-ri="596" type="text/json">{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26168" rel="nofollow" href="https://www.academia.edu/Documents/in/Dental_Materials">Dental Materials</a>, <script data-card-contents-for-ri="26168" type="text/json">{"id":26168,"name":"Dental Materials","url":"https://www.academia.edu/Documents/in/Dental_Materials?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a><script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=25950071]'), work: {"id":25950071,"title":"Adhesively restored anterior maxillary dentitions affected by severe erosion: up to 6-year results of a prospective clinical study","created_at":"2016-06-07T03:19:42.600-07:00","url":"https://www.academia.edu/25950071/Adhesively_restored_anterior_maxillary_dentitions_affected_by_severe_erosion_up_to_6_year_results_of_a_prospective_clinical_study?f_ri=137516","dom_id":"work_25950071","summary":"In case of severe dental erosion, the maxillary anterior teeth are often particularly affected. Restoring such teeth conventionally (ie, crowns) would frequently involve elective endodontic therapy and major additional loss of tooth structure. A novel, minimally invasive approach to restore eroded teeth has been developed and is currently being tested in the form of a prospective clinical trial, termed The Geneva Erosion Study. To avoid crowns, two separate veneers with different paths of insertion have been used to restore the affected anterior maxillary teeth, regardless of clinical crown length and amount of remaining enamel. This treatment is called The Sandwich Approach. The purpose of this case series study was to analyze the mid-term clinical outcome of maxillary anterior teeth affected by severe dental erosion that were restored following the Sandwich Approach. Twelve consecutively consulting patients (mean age: 39.4 years) suffering from advanced dental erosion have been en...","downloadable_attachments":[{"id":46304536,"asset_id":25950071,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":49712087,"first_name":"Linda","last_name":"Grütter","domain_name":"gfri","page_name":"LindaGrütter","display_name":"Linda Grütter","profile_url":"https://gfri.academia.edu/LindaGr%C3%BCtter?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":26168,"name":"Dental Materials","url":"https://www.academia.edu/Documents/in/Dental_Materials?f_ri=137516","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":144052,"name":"Patient Satisfaction","url":"https://www.academia.edu/Documents/in/Patient_Satisfaction?f_ri=137516"},{"id":345755,"name":"Dental Porcelain","url":"https://www.academia.edu/Documents/in/Dental_Porcelain?f_ri=137516"},{"id":385888,"name":"Composite resins","url":"https://www.academia.edu/Documents/in/Composite_resins?f_ri=137516"},{"id":413169,"name":"Vertical Dimension","url":"https://www.academia.edu/Documents/in/Vertical_Dimension?f_ri=137516"},{"id":429265,"name":"Incisor","url":"https://www.academia.edu/Documents/in/Incisor?f_ri=137516"},{"id":468992,"name":"Dental Prosthesis Design","url":"https://www.academia.edu/Documents/in/Dental_Prosthesis_Design?f_ri=137516"},{"id":666570,"name":"Dental Esthetics","url":"https://www.academia.edu/Documents/in/Dental_Esthetics?f_ri=137516"},{"id":678833,"name":"Dental Bonding","url":"https://www.academia.edu/Documents/in/Dental_Bonding?f_ri=137516"},{"id":1274878,"name":"Dental Veneers","url":"https://www.academia.edu/Documents/in/Dental_Veneers?f_ri=137516"},{"id":1436040,"name":"Potassium Compounds","url":"https://www.academia.edu/Documents/in/Potassium_Compounds?f_ri=137516"},{"id":2452650,"name":"Tooth Erosion","url":"https://www.academia.edu/Documents/in/Tooth_Erosion?f_ri=137516"},{"id":2457428,"name":"Dental Pulp","url":"https://www.academia.edu/Documents/in/Dental_Pulp?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11870838" data-work_id="11870838" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11870838/Systemic_Couple_Therapy_for_dysthymia">Systemic Couple Therapy for dysthymia</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We examined the effect of Systemic Couple Therapy on a patient diagnosed with dysthymic disorder and her partner. Marge and Peter, a middle-aged married couple, showed significant and meaningful changes in their pattern of interaction... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11870838" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We examined the effect of Systemic Couple Therapy on a patient diagnosed with dysthymic disorder and her partner. Marge and Peter, a middle-aged married couple, showed significant and meaningful changes in their pattern of interaction over the course of the therapy and, by the end of it, Marge no longer met the diagnostic criteria for dysthymic disorder. Her scores on the SCID-I and BDI-II were in the clinical range before treatment and in the non-clinical one at the end of therapy. Although scores on Dyadic Adjustment Scale showed different patterns, both members reported significant improvement. The analysis of change in the alliance-related behaviors throughout the process concurred with change in couple"s pattern of interaction.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11870838" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="afe56daa42267e195931a0acb4cb1d92" rel="nofollow" data-download="{"attachment_id":46473550,"asset_id":11870838,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46473550/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="3269148" href="https://independent.academia.edu/Compa%C3%B1Victoria">Victoria Compañ Felipe</a><script data-card-contents-for-user="3269148" type="text/json">{"id":3269148,"first_name":"Victoria","last_name":"Compañ Felipe","domain_name":"independent","page_name":"CompañVictoria","display_name":"Victoria Compañ Felipe","profile_url":"https://independent.academia.edu/Compa%C3%B1Victoria?f_ri=137516","photo":"https://0.academia-photos.com/3269148/1082302/152541921/s65_victoria.compa_.png"}</script></span></span></li><li class="js-paper-rank-work_11870838 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11870838"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11870838, container: ".js-paper-rank-work_11870838", }); });</script></li><li class="js-percentile-work_11870838 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11870838; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_11870838"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_11870838 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="11870838"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11870838; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11870838]").text(description); $(".js-view-count-work_11870838").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11870838").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11870838"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">11</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="859" rel="nofollow" href="https://www.academia.edu/Documents/in/Communication">Communication</a>, <script data-card-contents-for-ri="859" type="text/json">{"id":859,"name":"Communication","url":"https://www.academia.edu/Documents/in/Communication?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2240" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychotherapy">Psychotherapy</a>, <script data-card-contents-for-ri="2240" type="text/json">{"id":2240,"name":"Psychotherapy","url":"https://www.academia.edu/Documents/in/Psychotherapy?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3709" rel="nofollow" href="https://www.academia.edu/Documents/in/Evidence_Based_Practice">Evidence Based Practice</a><script data-card-contents-for-ri="3709" type="text/json">{"id":3709,"name":"Evidence Based Practice","url":"https://www.academia.edu/Documents/in/Evidence_Based_Practice?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11870838]'), work: {"id":11870838,"title":"Systemic Couple Therapy for dysthymia","created_at":"2015-04-09T11:05:50.742-07:00","url":"https://www.academia.edu/11870838/Systemic_Couple_Therapy_for_dysthymia?f_ri=137516","dom_id":"work_11870838","summary":"We examined the effect of Systemic Couple Therapy on a patient diagnosed with dysthymic disorder and her partner. Marge and Peter, a middle-aged married couple, showed significant and meaningful changes in their pattern of interaction over the course of the therapy and, by the end of it, Marge no longer met the diagnostic criteria for dysthymic disorder. Her scores on the SCID-I and BDI-II were in the clinical range before treatment and in the non-clinical one at the end of therapy. Although scores on Dyadic Adjustment Scale showed different patterns, both members reported significant improvement. The analysis of change in the alliance-related behaviors throughout the process concurred with change in couple\"s pattern of interaction.","downloadable_attachments":[{"id":46473550,"asset_id":11870838,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":3269148,"first_name":"Victoria","last_name":"Compañ Felipe","domain_name":"independent","page_name":"CompañVictoria","display_name":"Victoria Compañ Felipe","profile_url":"https://independent.academia.edu/Compa%C3%B1Victoria?f_ri=137516","photo":"https://0.academia-photos.com/3269148/1082302/152541921/s65_victoria.compa_.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=137516","nofollow":true},{"id":859,"name":"Communication","url":"https://www.academia.edu/Documents/in/Communication?f_ri=137516","nofollow":true},{"id":2240,"name":"Psychotherapy","url":"https://www.academia.edu/Documents/in/Psychotherapy?f_ri=137516","nofollow":true},{"id":3709,"name":"Evidence Based Practice","url":"https://www.academia.edu/Documents/in/Evidence_Based_Practice?f_ri=137516","nofollow":true},{"id":57912,"name":"Marriage","url":"https://www.academia.edu/Documents/in/Marriage?f_ri=137516"},{"id":73785,"name":"Personality Assessment Inventory","url":"https://www.academia.edu/Documents/in/Personality_Assessment_Inventory?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":264546,"name":"Marital Therapy","url":"https://www.academia.edu/Documents/in/Marital_Therapy?f_ri=137516"},{"id":455295,"name":"Mentors","url":"https://www.academia.edu/Documents/in/Mentors?f_ri=137516"},{"id":693683,"name":"EXPRESSED EMOTION","url":"https://www.academia.edu/Documents/in/EXPRESSED_EMOTION?f_ri=137516"},{"id":1157062,"name":"Family Conflict","url":"https://www.academia.edu/Documents/in/Family_Conflict?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17059205" data-work_id="17059205" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17059205/Residual_Language_Deficits_in_Optimal_Outcome_Children_with_a_History_of_Autism">Residual Language Deficits in Optimal Outcome Children with a History of Autism</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">This study examined whether language deficits persist even in children with optimal outcomes. We examined a group of children with prior diagnoses on the autism spectrum who had IQs in the normal range, were in age-appropriate mainstream... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17059205" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This study examined whether language deficits persist even in children with optimal outcomes. We examined a group of children with prior diagnoses on the autism spectrum who had IQs in the normal range, were in age-appropriate mainstream classes, and had improved to such an extent that they were considered to be functioning at the level of their typically developing peers. Fourteen such children between the ages of five and nine were matched on age and sex with typically developing children, and were given a battery of 10 language tests to investigate their language abilities. Results indicated that while these children's grammatical capabilities are mostly indistinguishable from their peers, they are still experiencing difficulties in pragmatic and semantic language.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17059205" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a170b671d160a9fc7a53196377229da2" rel="nofollow" data-download="{"attachment_id":42336641,"asset_id":17059205,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42336641/download_file?st=MTc0MDAzODM5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36623175" href="https://independent.academia.edu/DeborahFein">Deborah Fein</a><script data-card-contents-for-user="36623175" type="text/json">{"id":36623175,"first_name":"Deborah","last_name":"Fein","domain_name":"independent","page_name":"DeborahFein","display_name":"Deborah Fein","profile_url":"https://independent.academia.edu/DeborahFein?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17059205 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17059205"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17059205, container: ".js-paper-rank-work_17059205", }); });</script></li><li class="js-percentile-work_17059205 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17059205; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_17059205"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_17059205 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="17059205"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17059205; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17059205]").text(description); $(".js-view-count-work_17059205").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_17059205").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="17059205"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">13</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="922" rel="nofollow" href="https://www.academia.edu/Documents/in/Education">Education</a>, <script data-card-contents-for-ri="922" type="text/json">{"id":922,"name":"Education","url":"https://www.academia.edu/Documents/in/Education?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2249" rel="nofollow" href="https://www.academia.edu/Documents/in/Autism">Autism</a>, <script data-card-contents-for-ri="2249" type="text/json">{"id":2249,"name":"Autism","url":"https://www.academia.edu/Documents/in/Autism?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2349" rel="nofollow" href="https://www.academia.edu/Documents/in/Semantics">Semantics</a>, <script data-card-contents-for-ri="2349" type="text/json">{"id":2349,"name":"Semantics","url":"https://www.academia.edu/Documents/in/Semantics?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2674" rel="nofollow" href="https://www.academia.edu/Documents/in/Intelligence">Intelligence</a><script data-card-contents-for-ri="2674" type="text/json">{"id":2674,"name":"Intelligence","url":"https://www.academia.edu/Documents/in/Intelligence?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=17059205]'), work: {"id":17059205,"title":"Residual Language Deficits in Optimal Outcome Children with a History of Autism","created_at":"2015-10-20T12:43:14.398-07:00","url":"https://www.academia.edu/17059205/Residual_Language_Deficits_in_Optimal_Outcome_Children_with_a_History_of_Autism?f_ri=137516","dom_id":"work_17059205","summary":"This study examined whether language deficits persist even in children with optimal outcomes. We examined a group of children with prior diagnoses on the autism spectrum who had IQs in the normal range, were in age-appropriate mainstream classes, and had improved to such an extent that they were considered to be functioning at the level of their typically developing peers. Fourteen such children between the ages of five and nine were matched on age and sex with typically developing children, and were given a battery of 10 language tests to investigate their language abilities. Results indicated that while these children's grammatical capabilities are mostly indistinguishable from their peers, they are still experiencing difficulties in pragmatic and semantic language.","downloadable_attachments":[{"id":42336641,"asset_id":17059205,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36623175,"first_name":"Deborah","last_name":"Fein","domain_name":"independent","page_name":"DeborahFein","display_name":"Deborah Fein","profile_url":"https://independent.academia.edu/DeborahFein?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":922,"name":"Education","url":"https://www.academia.edu/Documents/in/Education?f_ri=137516","nofollow":true},{"id":2249,"name":"Autism","url":"https://www.academia.edu/Documents/in/Autism?f_ri=137516","nofollow":true},{"id":2349,"name":"Semantics","url":"https://www.academia.edu/Documents/in/Semantics?f_ri=137516","nofollow":true},{"id":2674,"name":"Intelligence","url":"https://www.academia.edu/Documents/in/Intelligence?f_ri=137516","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=137516"},{"id":112518,"name":"Communication Skill","url":"https://www.academia.edu/Documents/in/Communication_Skill?f_ri=137516"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":234882,"name":"Autism Spectrum Disorder","url":"https://www.academia.edu/Documents/in/Autism_Spectrum_Disorder?f_ri=137516"},{"id":321836,"name":"Spectrum","url":"https://www.academia.edu/Documents/in/Spectrum?f_ri=137516"},{"id":663998,"name":"Mainstreaming DRR Education","url":"https://www.academia.edu/Documents/in/Mainstreaming_DRR_Education?f_ri=137516"},{"id":701873,"name":"Asperger Syndrome","url":"https://www.academia.edu/Documents/in/Asperger_Syndrome?f_ri=137516"},{"id":978643,"name":"Typical Development","url":"https://www.academia.edu/Documents/in/Typical_Development?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16606218" data-work_id="16606218" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16606218/Deterioration_of_Growth_Hormone_GH_Response_and_Anterior_Pituitary_Function_in_Young_Adults_with_Childhood_Onset_GH_Deficiency_and_Ectopic_Posterior_Pituitary_A_Two_Year_Prospective_Follow_Up_Study">Deterioration of Growth Hormone (GH) Response and Anterior Pituitary Function in Young Adults with Childhood-Onset GH Deficiency and Ectopic Posterior Pituitary: A Two-Year Prospective Follow-Up Study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">The current criteria for definition of partial GHD in young adults are still a subject of debate.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16606218" data-share-source="work_strip" 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itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35941534" href="https://independent.academia.edu/MohamadMaghnie">Mohamad Maghnie</a><script data-card-contents-for-user="35941534" type="text/json">{"id":35941534,"first_name":"Mohamad","last_name":"Maghnie","domain_name":"independent","page_name":"MohamadMaghnie","display_name":"Mohamad Maghnie","profile_url":"https://independent.academia.edu/MohamadMaghnie?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16606218 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16606218"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16606218, container: ".js-paper-rank-work_16606218", }); });</script></li><li class="js-percentile-work_16606218 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16606218; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16606218"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16606218 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16606218"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16606218; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16606218]").text(description); $(".js-view-count-work_16606218").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16606218").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16606218"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">15</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance 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type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16606218]'), work: {"id":16606218,"title":"Deterioration of Growth Hormone (GH) Response and Anterior Pituitary Function in Young Adults with Childhood-Onset GH Deficiency and Ectopic Posterior Pituitary: A Two-Year Prospective Follow-Up Study","created_at":"2015-10-09T12:33:00.733-07:00","url":"https://www.academia.edu/16606218/Deterioration_of_Growth_Hormone_GH_Response_and_Anterior_Pituitary_Function_in_Young_Adults_with_Childhood_Onset_GH_Deficiency_and_Ectopic_Posterior_Pituitary_A_Two_Year_Prospective_Follow_Up_Study?f_ri=137516","dom_id":"work_16606218","summary":"The current criteria for definition of partial GHD in young adults are still a subject of debate.","downloadable_attachments":[{"id":40041376,"asset_id":16606218,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35941534,"first_name":"Mohamad","last_name":"Maghnie","domain_name":"independent","page_name":"MohamadMaghnie","display_name":"Mohamad Maghnie","profile_url":"https://independent.academia.edu/MohamadMaghnie?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=137516","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=137516","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=137516","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=137516","nofollow":true},{"id":69565,"name":"Human Growth Hormone","url":"https://www.academia.edu/Documents/in/Human_Growth_Hormone?f_ri=137516"},{"id":99708,"name":"Clinical","url":"https://www.academia.edu/Documents/in/Clinical?f_ri=137516"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index?f_ri=137516"},{"id":208591,"name":"Hypopituitarism","url":"https://www.academia.edu/Documents/in/Hypopituitarism?f_ri=137516"},{"id":227297,"name":"Waist Circumference","url":"https://www.academia.edu/Documents/in/Waist_Circumference?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":1274497,"name":"Total Cholesterol","url":"https://www.academia.edu/Documents/in/Total_Cholesterol?f_ri=137516"},{"id":1489115,"name":"Age of Onset","url":"https://www.academia.edu/Documents/in/Age_of_Onset?f_ri=137516"},{"id":1602990,"name":"Anterior Pituitary","url":"https://www.academia.edu/Documents/in/Anterior_Pituitary?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_46453100 coauthored" data-work_id="46453100" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/46453100/Oncocytic_mucoepidermoid_carcinoma_of_parotid_gland_origin">Oncocytic mucoepidermoid carcinoma of parotid gland origin</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/46453100" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="212176201" href="https://independent.academia.edu/KMitani">Keiko Mitani</a><script data-card-contents-for-user="212176201" type="text/json">{"id":212176201,"first_name":"Keiko","last_name":"Mitani","domain_name":"independent","page_name":"KMitani","display_name":"Keiko Mitani","profile_url":"https://independent.academia.edu/KMitani?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-46453100">+2</span><div class="hidden js-additional-users-46453100"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/JunkichiYokoyama">Junkichi Yokoyama</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/KatsuhisaIkeda">Katsuhisa Ikeda</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-46453100'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-46453100').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_46453100 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="46453100"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 46453100, container: ".js-paper-rank-work_46453100", }); });</script></li><li class="js-percentile-work_46453100 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 46453100; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_46453100"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_46453100 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="46453100"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 46453100; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=46453100]").text(description); $(".js-view-count-work_46453100").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_46453100").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="46453100"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">8</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="596" rel="nofollow" href="https://www.academia.edu/Documents/in/Dentistry">Dentistry</a>, <script data-card-contents-for-ri="596" type="text/json">{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="60436" rel="nofollow" href="https://www.academia.edu/Documents/in/Cell_Differentiation">Cell Differentiation</a>, <script data-card-contents-for-ri="60436" type="text/json">{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a>, <script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="289271" rel="nofollow" href="https://www.academia.edu/Documents/in/Aged">Aged</a><script data-card-contents-for-ri="289271" type="text/json">{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=46453100]'), work: {"id":46453100,"title":"Oncocytic mucoepidermoid carcinoma of parotid gland 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Ikeda","profile_url":"https://independent.academia.edu/KatsuhisaIkeda?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=137516","nofollow":true},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516","nofollow":true},{"id":321836,"name":"Spectrum","url":"https://www.academia.edu/Documents/in/Spectrum?f_ri=137516"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=137516"},{"id":792057,"name":"Parotid Gland","url":"https://www.academia.edu/Documents/in/Parotid_Gland?f_ri=137516"},{"id":966167,"name":"Salivary Gland","url":"https://www.academia.edu/Documents/in/Salivary_Gland?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_46460740 coauthored" data-work_id="46460740" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/46460740/Effect_of_isoniazid_preventive_therapy_on_risk_of_death_in_west_African_HIV_infected_adults_with_high_CD4_cell_counts_long_term_follow_up_of_the_Temprano_ANRS_12136_trial">Effect of isoniazid preventive therapy on risk of death in west African, HIV-infected adults with high CD4 cell counts: long-term follow-up of the Temprano ANRS 12136 trial</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Temprano ANRS 12136 was a factorial 2 × 2 trial that assessed the benefits of early antiretroviral therapy (ART; ie, in patients who had not reached the CD4 cell count threshold used to recommend starting ART, as per the WHO guidelines... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_46460740" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Temprano ANRS 12136 was a factorial 2 × 2 trial that assessed the benefits of early antiretroviral therapy (ART; ie, in patients who had not reached the CD4 cell count threshold used to recommend starting ART, as per the WHO guidelines that were the standard during the study period) and 6-month isoniazid preventive therapy (IPT) in HIV-infected adults in Côte d&#39;Ivoire. Early ART and IPT were shown to independently reduce the risk of severe morbidity at 30 months. Here, we present the efficacy of IPT in reducing mortality from the long-term follow-up of Temprano. For Temprano, participants were randomly assigned to four groups (deferred ART, deferred ART plus IPT, early ART, or early ART plus IPT). Participants who completed the trial follow-up were invited to participate in a post-trial phase. The primary post-trial phase endpoint was death, as analysed by the intention-to-treat principle. We used Cox proportional models to compare all-cause mortality between the IPT and no IPT ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/46460740" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="48057854" href="https://independent.academia.edu/MINGAAlbert">Albert MINGA</a><script data-card-contents-for-user="48057854" type="text/json">{"id":48057854,"first_name":"Albert","last_name":"MINGA","domain_name":"independent","page_name":"MINGAAlbert","display_name":"Albert MINGA","profile_url":"https://independent.academia.edu/MINGAAlbert?f_ri=137516","photo":"https://0.academia-photos.com/48057854/13334924/14578774/s65_albert.minga.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-46460740">+2</span><div class="hidden js-additional-users-46460740"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/MarcelleDaligou">Marcelle Daligou</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/AlexAni6">Alex Ani</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-46460740'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-46460740').html(); 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ie, in patients who had not reached the CD4 cell count threshold used to recommend starting ART, as per the WHO guidelines that were the standard during the study period) and 6-month isoniazid preventive therapy (IPT) in HIV-infected adults in Côte d\u0026#39;Ivoire. Early ART and IPT were shown to independently reduce the risk of severe morbidity at 30 months. Here, we present the efficacy of IPT in reducing mortality from the long-term follow-up of Temprano. For Temprano, participants were randomly assigned to four groups (deferred ART, deferred ART plus IPT, early ART, or early ART plus IPT). Participants who completed the trial follow-up were invited to participate in a post-trial phase. The primary post-trial phase endpoint was death, as analysed by the intention-to-treat principle. We used Cox proportional models to compare all-cause mortality between the IPT and no IPT ...","downloadable_attachments":[],"ordered_authors":[{"id":48057854,"first_name":"Albert","last_name":"MINGA","domain_name":"independent","page_name":"MINGAAlbert","display_name":"Albert MINGA","profile_url":"https://independent.academia.edu/MINGAAlbert?f_ri=137516","photo":"https://0.academia-photos.com/48057854/13334924/14578774/s65_albert.minga.jpg"},{"id":213194718,"first_name":"Marcelle","last_name":"Daligou","domain_name":"independent","page_name":"MarcelleDaligou","display_name":"Marcelle Daligou","profile_url":"https://independent.academia.edu/MarcelleDaligou?f_ri=137516","photo":"/images/s65_no_pic.png"},{"id":214577183,"first_name":"Alex","last_name":"Ani","domain_name":"independent","page_name":"AlexAni6","display_name":"Alex Ani","profile_url":"https://independent.academia.edu/AlexAni6?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy?f_ri=137516","nofollow":true},{"id":1036105,"name":"Isoniazid","url":"https://www.academia.edu/Documents/in/Isoniazid?f_ri=137516"},{"id":3554817,"name":"Anti-retroviral agents","url":"https://www.academia.edu/Documents/in/Anti-retroviral_agents?f_ri=137516"},{"id":3887581,"name":"HIV infections","url":"https://www.academia.edu/Documents/in/HIV_infections?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_81124102" data-work_id="81124102" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/81124102/Extended_Crescent_Mastopexy_with_Augmentation">Extended Crescent Mastopexy with Augmentation</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/81124102" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="31561c24674717724b9df097cb282e18" rel="nofollow" data-download="{"attachment_id":87277839,"asset_id":81124102,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/87277839/download_file?st=MTc0MDAzODM5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43212261" href="https://independent.academia.edu/Andr%C3%A9Auersvald">André Auersvald</a><script data-card-contents-for-user="43212261" type="text/json">{"id":43212261,"first_name":"André","last_name":"Auersvald","domain_name":"independent","page_name":"AndréAuersvald","display_name":"André Auersvald","profile_url":"https://independent.academia.edu/Andr%C3%A9Auersvald?f_ri=137516","photo":"https://0.academia-photos.com/43212261/11572232/12905805/s65_andr_.auersvald.jpeg"}</script></span></span></li><li class="js-paper-rank-work_81124102 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="81124102"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 81124102, container: ".js-paper-rank-work_81124102", }); 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$(".js-view-count[data-work-id=81124102]").text(description); $(".js-view-count-work_81124102").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_81124102").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="81124102"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">9</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="647" rel="nofollow" href="https://www.academia.edu/Documents/in/Surgery">Surgery</a>, <script data-card-contents-for-ri="647" type="text/json">{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="651" rel="nofollow" href="https://www.academia.edu/Documents/in/Plastic_Surgery">Plastic Surgery</a>, <script data-card-contents-for-ri="651" type="text/json">{"id":651,"name":"Plastic Surgery","url":"https://www.academia.edu/Documents/in/Plastic_Surgery?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=81124102]'), work: {"id":81124102,"title":"Extended Crescent Mastopexy with Augmentation","created_at":"2022-06-09T16:15:13.926-07:00","url":"https://www.academia.edu/81124102/Extended_Crescent_Mastopexy_with_Augmentation?f_ri=137516","dom_id":"work_81124102","summary":null,"downloadable_attachments":[{"id":87277839,"asset_id":81124102,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43212261,"first_name":"André","last_name":"Auersvald","domain_name":"independent","page_name":"AndréAuersvald","display_name":"André Auersvald","profile_url":"https://independent.academia.edu/Andr%C3%A9Auersvald?f_ri=137516","photo":"https://0.academia-photos.com/43212261/11572232/12905805/s65_andr_.auersvald.jpeg"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=137516","nofollow":true},{"id":651,"name":"Plastic Surgery","url":"https://www.academia.edu/Documents/in/Plastic_Surgery?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":209519,"name":"Breast Augmentation","url":"https://www.academia.edu/Documents/in/Breast_Augmentation?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=137516"},{"id":3614920,"name":"Mastopexy","url":"https://www.academia.edu/Documents/in/Mastopexy?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_79151034" data-work_id="79151034" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/79151034/Free_Functioning_Gracilis_Muscle_Transfer_for_Elbow_Flexion_Reconstruction_after_Traumatic_Adult_Brachial_Pan_Plexus_Injury_Where_Is_the_Optimal_Distal_Tendon_Attachment_for_Elbow_Flexion">Free Functioning Gracilis Muscle Transfer for Elbow Flexion Reconstruction after Traumatic Adult Brachial Pan-Plexus Injury: Where Is the Optimal Distal Tendon Attachment for Elbow Flexion?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Reconstruction after pan-plexus root avulsions often includes gracilis free functioning muscle transfer. For elbow flexion reconstruction, the free functioning muscle transfer distal tendon is inserted into the biceps tendon or more... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_79151034" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Reconstruction after pan-plexus root avulsions often includes gracilis free functioning muscle transfer. For elbow flexion reconstruction, the free functioning muscle transfer distal tendon is inserted into the biceps tendon or more distally (i.e., flexor digitorum profundus/flexor pollicis longus tendons) for combined elbow and finger flexion; the theoretical drawback of the latter approach is weaker elbow flexion. The authors compared elbow flexion strength with a biceps tendon versus a flexor digitorum profundus/flexor pollicis longus tendon attachment to determine which insertion point resulted in better elbow flexion. Thirty-nine patients underwent free functioning muscle transfer with either a biceps tendon or a distal attachment. Groups were compared on postoperative elbow flexion strength, preoperative and postoperative Disabilities of the Arm, Shoulder, and Hand questionnaire scores, range of motion, and other surgical and demographic characteristics. A biomechanical analys...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/79151034" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b132bd6ba05ae56a2513879ac1a1e87a" rel="nofollow" data-download="{"attachment_id":85966098,"asset_id":79151034,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85966098/download_file?st=MTc0MDAzODM5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5720798" href="https://mayoclinic.academia.edu/SantiagoRomeroBrufau">Santiago Romero Brufau</a><script data-card-contents-for-user="5720798" type="text/json">{"id":5720798,"first_name":"Santiago","last_name":"Romero Brufau","domain_name":"mayoclinic","page_name":"SantiagoRomeroBrufau","display_name":"Santiago Romero Brufau","profile_url":"https://mayoclinic.academia.edu/SantiagoRomeroBrufau?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_79151034 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="79151034"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 79151034, container: ".js-paper-rank-work_79151034", }); 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$(".js-view-count[data-work-id=79151034]").text(description); $(".js-view-count-work_79151034").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_79151034").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="79151034"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">14</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="53714" rel="nofollow" href="https://www.academia.edu/Documents/in/Plastic_and_Reconstructive_Surgery">Plastic and Reconstructive Surgery</a>, <script data-card-contents-for-ri="53714" type="text/json">{"id":53714,"name":"Plastic and Reconstructive Surgery","url":"https://www.academia.edu/Documents/in/Plastic_and_Reconstructive_Surgery?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a><script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=79151034]'), work: {"id":79151034,"title":"Free Functioning Gracilis Muscle Transfer for Elbow Flexion Reconstruction after Traumatic Adult Brachial Pan-Plexus Injury: Where Is the Optimal Distal Tendon Attachment for Elbow Flexion?","created_at":"2022-05-15T13:27:42.444-07:00","url":"https://www.academia.edu/79151034/Free_Functioning_Gracilis_Muscle_Transfer_for_Elbow_Flexion_Reconstruction_after_Traumatic_Adult_Brachial_Pan_Plexus_Injury_Where_Is_the_Optimal_Distal_Tendon_Attachment_for_Elbow_Flexion?f_ri=137516","dom_id":"work_79151034","summary":"Reconstruction after pan-plexus root avulsions often includes gracilis free functioning muscle transfer. For elbow flexion reconstruction, the free functioning muscle transfer distal tendon is inserted into the biceps tendon or more distally (i.e., flexor digitorum profundus/flexor pollicis longus tendons) for combined elbow and finger flexion; the theoretical drawback of the latter approach is weaker elbow flexion. The authors compared elbow flexion strength with a biceps tendon versus a flexor digitorum profundus/flexor pollicis longus tendon attachment to determine which insertion point resulted in better elbow flexion. Thirty-nine patients underwent free functioning muscle transfer with either a biceps tendon or a distal attachment. Groups were compared on postoperative elbow flexion strength, preoperative and postoperative Disabilities of the Arm, Shoulder, and Hand questionnaire scores, range of motion, and other surgical and demographic characteristics. A biomechanical analys...","downloadable_attachments":[{"id":85966098,"asset_id":79151034,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5720798,"first_name":"Santiago","last_name":"Romero Brufau","domain_name":"mayoclinic","page_name":"SantiagoRomeroBrufau","display_name":"Santiago Romero Brufau","profile_url":"https://mayoclinic.academia.edu/SantiagoRomeroBrufau?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=137516","nofollow":true},{"id":53714,"name":"Plastic and Reconstructive Surgery","url":"https://www.academia.edu/Documents/in/Plastic_and_Reconstructive_Surgery?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":352624,"name":"Elbow Joint","url":"https://www.academia.edu/Documents/in/Elbow_Joint?f_ri=137516"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=137516"},{"id":492272,"name":"Brachial Plexus","url":"https://www.academia.edu/Documents/in/Brachial_Plexus?f_ri=137516"},{"id":1157201,"name":"Tendons","url":"https://www.academia.edu/Documents/in/Tendons?f_ri=137516"},{"id":1902100,"name":"Biomechanical Phenomena","url":"https://www.academia.edu/Documents/in/Biomechanical_Phenomena?f_ri=137516"},{"id":2043485,"name":"Peripheral nerve injuries","url":"https://www.academia.edu/Documents/in/Peripheral_nerve_injuries?f_ri=137516"},{"id":2812488,"name":"elbow","url":"https://www.academia.edu/Documents/in/elbow?f_ri=137516"},{"id":3614065,"name":"free tissue flaps","url":"https://www.academia.edu/Documents/in/free_tissue_flaps?f_ri=137516"},{"id":3724725,"name":"Reconstructive Surgical Procedures","url":"https://www.academia.edu/Documents/in/Reconstructive_Surgical_Procedures?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_78682059" data-work_id="78682059" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/78682059/Hereditary_breast_and_ovarian_cancer_primary_and_secondary_prevention_for_BRCA1_and_BRCA2_mutation_carriers">Hereditary breast and ovarian cancer: primary and secondary prevention for BRCA1 and BRCA2 mutation carriers</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Diez años después de la identificación de los genes de predisposición hereditaria al cáncer de mama y ovario, BRCA1 y BRCA2, disponemos de estudios prospectivos observacionales que han evaluado la eficacia de las estrategias de prevención... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_78682059" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Diez años después de la identificación de los genes de predisposición hereditaria al cáncer de mama y ovario, BRCA1 y BRCA2, disponemos de estudios prospectivos observacionales que han evaluado la eficacia de las estrategias de prevención primaria y secundaria de neoplasias de mama y ovario en estas pacientes. La incorporación de la resonancia magnética mamaria al cribado del cáncer de mama en estas pacientes permite incrementar la sensibilidad del cribado y un diagnóstico más precoz del cáncer de mama, si bien aún no tenemos evidencia de que esta estrategia pueda tener un impacto en la mortalidad. Al no disponer de una estrategia eficaz para el cribado del cáncer de ovario, la salpingooforectomía bilateral profiláctica se considera la estrategia preventiva más eficaz para reducir el riesgo de cáncer de ovario. Además, también reduce de forma significativa el riesgo de cáncer de mama si se realiza antes de los 50 años. El manejo de estas pacientes deberá ser individualizado y multidisciplinario. Palabras clave: Cáncer de mama. Cáncer de ovario. Prevención. BRCA1. BRCA2. Hereditary breast and ovarian cancer: primary and secondary prevention for BRCA1 and BRCA2 mutation carriers Ten years after the identification of the breast and ovarian cancer predisposition genes, BRCA1 and BRCA2, an emerging literature has explored the efficacy of strategies for primary as well as secondary prevention of breast and ovarian cancer in BRCA1 and BRCA2 mutations carriers. The integration of magnetic resonance imaging for breast cancer screening in BRCA carriers has achieved a higher sensibility of the screening, and an early detection of breast cancer. However, we don't have yet enough level of evidence that magnetic resonance imaging could reduce mortality in BRCA carriers. Because of the limitations of screening for ovarian cancer, bilateral prophylactic salpingo-oophorectomy has been established as one of the most effective strategies to prevent ovarian cancer in BRCA1 and BRCA2 mutation carriers. This strategy also has a favorable effect on the reduction of risk of breast cancer if is performed before the age of 50. The management of this patients must be individualized and multidisciplinary.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/78682059" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="25e6913e3db924249719e9ff8c2f7240" rel="nofollow" data-download="{"attachment_id":85644214,"asset_id":78682059,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85644214/download_file?st=MTc0MDAzODM5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34385917" href="https://independent.academia.edu/IgnacioBlanco3">Ignacio Blanco</a><script data-card-contents-for-user="34385917" type="text/json">{"id":34385917,"first_name":"Ignacio","last_name":"Blanco","domain_name":"independent","page_name":"IgnacioBlanco3","display_name":"Ignacio Blanco","profile_url":"https://independent.academia.edu/IgnacioBlanco3?f_ri=137516","photo":"https://0.academia-photos.com/34385917/161611645/151340139/s65_ignacio.blanco.png"}</script></span></span></li><li class="js-paper-rank-work_78682059 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="78682059"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 78682059, container: ".js-paper-rank-work_78682059", }); });</script></li><li class="js-percentile-work_78682059 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78682059; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_78682059"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_78682059 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="78682059"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78682059; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78682059]").text(description); $(".js-view-count-work_78682059").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_78682059").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="78682059"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">12</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7471" rel="nofollow" href="https://www.academia.edu/Documents/in/Life_Style">Life Style</a>, <script data-card-contents-for-ri="7471" type="text/json">{"id":7471,"name":"Life Style","url":"https://www.academia.edu/Documents/in/Life_Style?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="27240" rel="nofollow" href="https://www.academia.edu/Documents/in/Prevention">Prevention</a><script data-card-contents-for-ri="27240" type="text/json">{"id":27240,"name":"Prevention","url":"https://www.academia.edu/Documents/in/Prevention?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=78682059]'), work: {"id":78682059,"title":"Hereditary breast and ovarian cancer: primary and secondary prevention for BRCA1 and BRCA2 mutation carriers","created_at":"2022-05-07T08:07:50.839-07:00","url":"https://www.academia.edu/78682059/Hereditary_breast_and_ovarian_cancer_primary_and_secondary_prevention_for_BRCA1_and_BRCA2_mutation_carriers?f_ri=137516","dom_id":"work_78682059","summary":"Diez años después de la identificación de los genes de predisposición hereditaria al cáncer de mama y ovario, BRCA1 y BRCA2, disponemos de estudios prospectivos observacionales que han evaluado la eficacia de las estrategias de prevención primaria y secundaria de neoplasias de mama y ovario en estas pacientes. La incorporación de la resonancia magnética mamaria al cribado del cáncer de mama en estas pacientes permite incrementar la sensibilidad del cribado y un diagnóstico más precoz del cáncer de mama, si bien aún no tenemos evidencia de que esta estrategia pueda tener un impacto en la mortalidad. Al no disponer de una estrategia eficaz para el cribado del cáncer de ovario, la salpingooforectomía bilateral profiláctica se considera la estrategia preventiva más eficaz para reducir el riesgo de cáncer de ovario. Además, también reduce de forma significativa el riesgo de cáncer de mama si se realiza antes de los 50 años. El manejo de estas pacientes deberá ser individualizado y multidisciplinario. Palabras clave: Cáncer de mama. Cáncer de ovario. Prevención. BRCA1. BRCA2. Hereditary breast and ovarian cancer: primary and secondary prevention for BRCA1 and BRCA2 mutation carriers Ten years after the identification of the breast and ovarian cancer predisposition genes, BRCA1 and BRCA2, an emerging literature has explored the efficacy of strategies for primary as well as secondary prevention of breast and ovarian cancer in BRCA1 and BRCA2 mutations carriers. The integration of magnetic resonance imaging for breast cancer screening in BRCA carriers has achieved a higher sensibility of the screening, and an early detection of breast cancer. However, we don't have yet enough level of evidence that magnetic resonance imaging could reduce mortality in BRCA carriers. Because of the limitations of screening for ovarian cancer, bilateral prophylactic salpingo-oophorectomy has been established as one of the most effective strategies to prevent ovarian cancer in BRCA1 and BRCA2 mutation carriers. This strategy also has a favorable effect on the reduction of risk of breast cancer if is performed before the age of 50. The management of this patients must be individualized and multidisciplinary.","downloadable_attachments":[{"id":85644214,"asset_id":78682059,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34385917,"first_name":"Ignacio","last_name":"Blanco","domain_name":"independent","page_name":"IgnacioBlanco3","display_name":"Ignacio Blanco","profile_url":"https://independent.academia.edu/IgnacioBlanco3?f_ri=137516","photo":"https://0.academia-photos.com/34385917/161611645/151340139/s65_ignacio.blanco.png"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=137516","nofollow":true},{"id":7471,"name":"Life Style","url":"https://www.academia.edu/Documents/in/Life_Style?f_ri=137516","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=137516","nofollow":true},{"id":27240,"name":"Prevention","url":"https://www.academia.edu/Documents/in/Prevention?f_ri=137516","nofollow":true},{"id":95519,"name":"Selenium","url":"https://www.academia.edu/Documents/in/Selenium?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=137516"},{"id":285789,"name":"Tamoxifen","url":"https://www.academia.edu/Documents/in/Tamoxifen?f_ri=137516"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=137516"},{"id":1013018,"name":"Medicina Clinica","url":"https://www.academia.edu/Documents/in/Medicina_Clinica?f_ri=137516"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms?f_ri=137516"},{"id":3881525,"name":"Ovarian Neoplasms","url":"https://www.academia.edu/Documents/in/Ovarian_Neoplasms?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_78326898" data-work_id="78326898" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/78326898/Prevalence_and_clinical_implications_of_painful_diabetic_peripheral_neuropathy_in_type_2_diabetes_Results_from_a_nationwide_hospital_based_study_of_diabetic_neuropathy_in_Korea">Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes: Results from a nationwide hospital-based study of diabetic neuropathy in Korea</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Aims: To determine the prevalence and risk factors for painful diabetic peripheral neuropathy (PDPN) and evaluate sleep impairment and quality of life in patients with PDPN. Methods: Data from the Korean Diabetes Association Neuropathy... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_78326898" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Aims: To determine the prevalence and risk factors for painful diabetic peripheral neuropathy (PDPN) and evaluate sleep impairment and quality of life in patients with PDPN. Methods: Data from the Korean Diabetes Association Neuropathy Study Group were used to evaluate 3999 patients with type 2 diabetes. PDPN was diagnosed using visual analogue scales (VAS) and medical history. The patients were asked to answer the Brief Pain Inventory-Short Form (BPI-SF), Medical Outcomes Study Sleep (MOS-Sleep) Scale, EuroQol (EQ-5D), and VAS. Results: Among the patients with diabetic peripheral neuropathy (n = 1338), 577 (43.1%) were diagnosed with PDPN (14.4% of all patients with type 2 diabetes). PDPN was independently associated with age, female gender, fasting plasma glucose, hypertension, and previous cerebrovascular events. All pain severity and interference measures were higher in patients with PDPN than in non-PDPN patients, and patients with PDPN reported more impaired sleep and lower EQ-5D and VAS scores. Conclusions: The prevalence of PDPN in Koreans was comparable to that in Western populations. PDPN may impair sleep and quality of life compared with non-PDPN, and physicians should carefully consider pain symptoms in patients with diabetic peripheral neuropathy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/78326898" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3d004f46abef0f857c4148479a75b2e2" rel="nofollow" data-download="{"attachment_id":85413300,"asset_id":78326898,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85413300/download_file?st=MTc0MDAzODM5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36132923" href="https://independent.academia.edu/BongyunCha">Bong-yun Cha</a><script data-card-contents-for-user="36132923" type="text/json">{"id":36132923,"first_name":"Bong-yun","last_name":"Cha","domain_name":"independent","page_name":"BongyunCha","display_name":"Bong-yun Cha","profile_url":"https://independent.academia.edu/BongyunCha?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_78326898 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="78326898"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 78326898, container: ".js-paper-rank-work_78326898", }); 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$(".js-view-count[data-work-id=78326898]").text(description); $(".js-view-count-work_78326898").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_78326898").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="78326898"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">14</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2898" rel="nofollow" href="https://www.academia.edu/Documents/in/Pain">Pain</a>, <script data-card-contents-for-ri="2898" type="text/json">{"id":2898,"name":"Pain","url":"https://www.academia.edu/Documents/in/Pain?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7470" rel="nofollow" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37772" rel="nofollow" href="https://www.academia.edu/Documents/in/Hospitals">Hospitals</a>, <script data-card-contents-for-ri="37772" type="text/json">{"id":37772,"name":"Hospitals","url":"https://www.academia.edu/Documents/in/Hospitals?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="106431" rel="nofollow" href="https://www.academia.edu/Documents/in/Sleep_disorders">Sleep disorders</a><script data-card-contents-for-ri="106431" type="text/json">{"id":106431,"name":"Sleep disorders","url":"https://www.academia.edu/Documents/in/Sleep_disorders?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=78326898]'), work: {"id":78326898,"title":"Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes: Results from a nationwide hospital-based study of diabetic neuropathy in Korea","created_at":"2022-05-03T06:29:17.824-07:00","url":"https://www.academia.edu/78326898/Prevalence_and_clinical_implications_of_painful_diabetic_peripheral_neuropathy_in_type_2_diabetes_Results_from_a_nationwide_hospital_based_study_of_diabetic_neuropathy_in_Korea?f_ri=137516","dom_id":"work_78326898","summary":"Aims: To determine the prevalence and risk factors for painful diabetic peripheral neuropathy (PDPN) and evaluate sleep impairment and quality of life in patients with PDPN. Methods: Data from the Korean Diabetes Association Neuropathy Study Group were used to evaluate 3999 patients with type 2 diabetes. PDPN was diagnosed using visual analogue scales (VAS) and medical history. The patients were asked to answer the Brief Pain Inventory-Short Form (BPI-SF), Medical Outcomes Study Sleep (MOS-Sleep) Scale, EuroQol (EQ-5D), and VAS. Results: Among the patients with diabetic peripheral neuropathy (n = 1338), 577 (43.1%) were diagnosed with PDPN (14.4% of all patients with type 2 diabetes). PDPN was independently associated with age, female gender, fasting plasma glucose, hypertension, and previous cerebrovascular events. All pain severity and interference measures were higher in patients with PDPN than in non-PDPN patients, and patients with PDPN reported more impaired sleep and lower EQ-5D and VAS scores. Conclusions: The prevalence of PDPN in Koreans was comparable to that in Western populations. PDPN may impair sleep and quality of life compared with non-PDPN, and physicians should carefully consider pain symptoms in patients with diabetic peripheral neuropathy.","downloadable_attachments":[{"id":85413300,"asset_id":78326898,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36132923,"first_name":"Bong-yun","last_name":"Cha","domain_name":"independent","page_name":"BongyunCha","display_name":"Bong-yun Cha","profile_url":"https://independent.academia.edu/BongyunCha?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2898,"name":"Pain","url":"https://www.academia.edu/Documents/in/Pain?f_ri=137516","nofollow":true},{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=137516","nofollow":true},{"id":37772,"name":"Hospitals","url":"https://www.academia.edu/Documents/in/Hospitals?f_ri=137516","nofollow":true},{"id":106431,"name":"Sleep disorders","url":"https://www.academia.edu/Documents/in/Sleep_disorders?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":273748,"name":"Republic of Korea","url":"https://www.academia.edu/Documents/in/Republic_of_Korea?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=137516"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=137516"},{"id":897823,"name":"Elsevier","url":"https://www.academia.edu/Documents/in/Elsevier?f_ri=137516"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus?f_ri=137516"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=137516"},{"id":2921997,"name":"Diabetic Neuropathies","url":"https://www.academia.edu/Documents/in/Diabetic_Neuropathies?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_77231442" data-work_id="77231442" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/77231442/Clinic_and_radiological_improvement_of_lipoid_pneumonia_with_multiple_bronchoalveolar_lavages">Clinic and radiological improvement of lipoid pneumonia with multiple bronchoalveolar lavages</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To assess the potential role of multiple bronchoalveolar lavages (BALs) in the treatment of children with lipoid pneumonia (LP). This prospective study included 10 children (7 female, 3 male) with LP secondary to mineral oil aspiration.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_77231442" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To assess the potential role of multiple bronchoalveolar lavages (BALs) in the treatment of children with lipoid pneumonia (LP). This prospective study included 10 children (7 female, 3 male) with LP secondary to mineral oil aspiration. The age ranged from 3 months to 7 years and 1-60 days history of mineral oil intake, with a 6 months clinic follow-up. High-resolution computer tomography (CT) was performed 1-7 days prior to treatment and 2-20 days after the last therapeutic BAL, and reviewed by two experienced chest radiologists. Oxygen saturation was measured with digital oximetry. Therapeutic BAL was performed weekly until BAL fluid was nearly transparent and the cell count returned to normal range values. In all children, the initial CT scans showed multifocal bilateral consolidation involving mainly the dorsal and central regions. The areas of consolidation had foci of decreased attenuation in eight patients. Following a total of 4-10 therapeutic BALs, the CT scans returned to normal in 3 patients, improved considerably in 5, and showed only slight improvement in 2. Oxygen saturation increased from 88.8 +/- 3.4% at presentation to 96.2 +/- 0.8% after treatment (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001). Multiple lavages reduced (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.003) numbers of lipid-laden macrophages and restored BAL cellularity to normal range values. Multiple therapeutic BAL of children with LP results in significant improvement of CT findings, oxygen saturation, restoration of BAL fluid cellularity and clinical recover without any evidence of respiratory distress at the end of treatment and 6 months after the last BAL.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/77231442" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bd0f65d430ccc124025c2d178f40cf86" rel="nofollow" data-download="{"attachment_id":84979351,"asset_id":77231442,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/84979351/download_file?st=MTc0MDAzODM5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="55646102" href="https://independent.academia.edu/selmasias">selma sias</a><script data-card-contents-for-user="55646102" type="text/json">{"id":55646102,"first_name":"selma","last_name":"sias","domain_name":"independent","page_name":"selmasias","display_name":"selma sias","profile_url":"https://independent.academia.edu/selmasias?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_77231442 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="77231442"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 77231442, container: ".js-paper-rank-work_77231442", }); 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This prospective study included 10 children (7 female, 3 male) with LP secondary to mineral oil aspiration. The age ranged from 3 months to 7 years and 1-60 days history of mineral oil intake, with a 6 months clinic follow-up. High-resolution computer tomography (CT) was performed 1-7 days prior to treatment and 2-20 days after the last therapeutic BAL, and reviewed by two experienced chest radiologists. Oxygen saturation was measured with digital oximetry. Therapeutic BAL was performed weekly until BAL fluid was nearly transparent and the cell count returned to normal range values. In all children, the initial CT scans showed multifocal bilateral consolidation involving mainly the dorsal and central regions. The areas of consolidation had foci of decreased attenuation in eight patients. Following a total of 4-10 therapeutic BALs, the CT scans returned to normal in 3 patients, improved considerably in 5, and showed only slight improvement in 2. Oxygen saturation increased from 88.8 +/- 3.4% at presentation to 96.2 +/- 0.8% after treatment (P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001). Multiple lavages reduced (P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.003) numbers of lipid-laden macrophages and restored BAL cellularity to normal range values. Multiple therapeutic BAL of children with LP results in significant improvement of CT findings, oxygen saturation, restoration of BAL fluid cellularity and clinical recover without any evidence of respiratory distress at the end of treatment and 6 months after the last BAL.","downloadable_attachments":[{"id":84979351,"asset_id":77231442,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":55646102,"first_name":"selma","last_name":"sias","domain_name":"independent","page_name":"selmasias","display_name":"selma sias","profile_url":"https://independent.academia.edu/selmasias?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=137516","nofollow":true},{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment?f_ri=137516","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=137516","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=137516"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=137516"},{"id":100657,"name":"Therapy","url":"https://www.academia.edu/Documents/in/Therapy?f_ri=137516"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=137516"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric?f_ri=137516"},{"id":227842,"name":"Pediatric Pulmonology","url":"https://www.academia.edu/Documents/in/Pediatric_Pulmonology?f_ri=137516"},{"id":387466,"name":"Multiple","url":"https://www.academia.edu/Documents/in/Multiple?f_ri=137516"},{"id":466476,"name":"Bronchoscopy","url":"https://www.academia.edu/Documents/in/Bronchoscopy?f_ri=137516"},{"id":571425,"name":"Oximetry","url":"https://www.academia.edu/Documents/in/Oximetry?f_ri=137516"},{"id":2005397,"name":"Bronchoalveolar lavage","url":"https://www.academia.edu/Documents/in/Bronchoalveolar_lavage?f_ri=137516"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=137516"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_76475119" data-work_id="76475119" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/76475119/Selecting_a_Surgical_Modality_to_Treat_a_Splenic_Hydatid_Cyst_Total_Splenectomy_or_Spleen_Saving_Surgery">Selecting a Surgical Modality to Treat a Splenic Hydatid Cyst: Total Splenectomy or Spleen-Saving Surgery?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Aim We analyzed the outcomes and effectiveness of surgical treatments and clinical manifestations of splenic hydatid cysts. Patients and Methods Between 2000 and 2011, we retrospectively reviewed the cases of 11 patients who were operated... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_76475119" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Aim We analyzed the outcomes and effectiveness of surgical treatments and clinical manifestations of splenic hydatid cysts. Patients and Methods Between 2000 and 2011, we retrospectively reviewed the cases of 11 patients who were operated on for a splenic hydatid cyst. The demographic features, medical history, physical examinations, biochemical and serological tests, imaging modalities, and surgical treatment of the patients were noted. Results The mean patient age was 36.45 years (range, 20-66 years). While isolated splenic hydatid disease was present in five patients, other abdominal hydatid cysts were accompanied by a splenic hydatid cyst in six patients. Left upper abdominal pain was present in seven (64%) patients, whereas four (36%) patients were asymptomatic. Eight patients (72.72%) had undergone a total splenectomy and three (27.28%) had undergone spleen-preserving surgery. Postoperative complications developed in four (36%) patients at 5-15 days postoperatively. Conclusion Management of a splenic hydatid cyst is not consensual. Total splenectomy is optimal because it provides definitive treatment. However, spleen-preserving surgery is the preferred treatment in selected patients. The choice of technique depends on the localization, number, and size of hydatid cysts, and the absence or presence of other hydatic organ cysts.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/76475119" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="000a74d7dd63c854e5602faa0432d47f" rel="nofollow" data-download="{"attachment_id":84172242,"asset_id":76475119,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/84172242/download_file?st=MTc0MDAzODM5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39133674" href="https://independent.academia.edu/FatihTaskesen">Fatih Taskesen</a><script data-card-contents-for-user="39133674" type="text/json">{"id":39133674,"first_name":"Fatih","last_name":"Taskesen","domain_name":"independent","page_name":"FatihTaskesen","display_name":"Fatih Taskesen","profile_url":"https://independent.academia.edu/FatihTaskesen?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_76475119 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="76475119"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 76475119, container: ".js-paper-rank-work_76475119", }); 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$(".js-view-count[data-work-id=76475119]").text(description); $(".js-view-count-work_76475119").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_76475119").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="76475119"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">14</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49018" rel="nofollow" href="https://www.academia.edu/Documents/in/Spleen">Spleen</a>, <script data-card-contents-for-ri="49018" type="text/json">{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen?f_ri=137516","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="133057" rel="nofollow" href="https://www.academia.edu/Documents/in/Young_Adult">Young Adult</a><script data-card-contents-for-ri="133057" type="text/json">{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=137516","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=76475119]'), work: {"id":76475119,"title":"Selecting a Surgical Modality to Treat a Splenic Hydatid Cyst: Total Splenectomy or Spleen-Saving Surgery?","created_at":"2022-04-14T19:01:02.035-07:00","url":"https://www.academia.edu/76475119/Selecting_a_Surgical_Modality_to_Treat_a_Splenic_Hydatid_Cyst_Total_Splenectomy_or_Spleen_Saving_Surgery?f_ri=137516","dom_id":"work_76475119","summary":"Aim We analyzed the outcomes and effectiveness of surgical treatments and clinical manifestations of splenic hydatid cysts. Patients and Methods Between 2000 and 2011, we retrospectively reviewed the cases of 11 patients who were operated on for a splenic hydatid cyst. The demographic features, medical history, physical examinations, biochemical and serological tests, imaging modalities, and surgical treatment of the patients were noted. Results The mean patient age was 36.45 years (range, 20-66 years). While isolated splenic hydatid disease was present in five patients, other abdominal hydatid cysts were accompanied by a splenic hydatid cyst in six patients. Left upper abdominal pain was present in seven (64%) patients, whereas four (36%) patients were asymptomatic. Eight patients (72.72%) had undergone a total splenectomy and three (27.28%) had undergone spleen-preserving surgery. Postoperative complications developed in four (36%) patients at 5-15 days postoperatively. Conclusion Management of a splenic hydatid cyst is not consensual. Total splenectomy is optimal because it provides definitive treatment. However, spleen-preserving surgery is the preferred treatment in selected patients. The choice of technique depends on the localization, number, and size of hydatid cysts, and the absence or presence of other hydatic organ cysts.","downloadable_attachments":[{"id":84172242,"asset_id":76475119,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39133674,"first_name":"Fatih","last_name":"Taskesen","domain_name":"independent","page_name":"FatihTaskesen","display_name":"Fatih Taskesen","profile_url":"https://independent.academia.edu/FatihTaskesen?f_ri=137516","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=137516","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=137516","nofollow":true},{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen?f_ri=137516","nofollow":true},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=137516","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=137516"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=137516"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=137516"},{"id":409362,"name":"Echinococcosis","url":"https://www.academia.edu/Documents/in/Echinococcosis?f_ri=137516"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=137516"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=137516"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay?f_ri=137516"},{"id":1329459,"name":"Echinococcus","url":"https://www.academia.edu/Documents/in/Echinococcus?f_ri=137516"},{"id":2190600,"name":"Splenectomy","url":"https://www.academia.edu/Documents/in/Splenectomy?f_ri=137516"},{"id":3323539,"name":"Gastrointestinal surgery","url":"https://www.academia.edu/Documents/in/Gastrointestinal_surgery?f_ri=137516"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_75888735" data-work_id="75888735" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/75888735/Evaluation_of_whether_intracameral_dexamethasone_predisposes_to_glaucoma_after_pediatric_cataract_surgery">Evaluation of whether intracameral dexamethasone predisposes to glaucoma after pediatric cataract surgery</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">To evaluate the effect of intracameral dexamethasone during pediatric cataract surgery on the incidence of postoperative glaucoma.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/75888735" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dcb34dd2e86fab42fa24e3743e3ac9a3" rel="nofollow" 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u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The prevalence of obesity is higher in those with intellectual disabilities than the general population. The aim of the study was to understand the determinants of physical activity and dietary patterns in this population during their... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73685389" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The prevalence of obesity is higher in those with intellectual disabilities than the general population. The aim of the study was to understand the determinants of physical activity and dietary patterns in this population during their final year of school. Qualitative data were generated from 10 interviews with adolescents with mild-moderate intellectual disabilities. Data were analysed using deductive thematic analysis, employing Self-Determination Theory as a theoretical framework. Adolescents&#39; environment and social interactions play a pivotal role in influencing physical activity and dietary patterns. Three themes emerged from the analysis: situatedness, motivation and wider environmental influences. School structure, high self-efficacy and social connectedness facilitate increased physical activity and healthier diet in adolescents with intellectual disabilities. Home life, low self-efficacy and a lack of social connectedness can serve as a barrier to PA and a healthy diet.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73685389" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="98eced89e4a3f488d1bc07f46d3e7046" rel="nofollow" data-download="{"attachment_id":82110039,"asset_id":73685389,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82110039/download_file?st=MTc0MDAzODM5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38846937" href="https://independent.academia.edu/AndrewJahoda">Andrew Jahoda</a><script data-card-contents-for-user="38846937" type="text/json">{"id":38846937,"first_name":"Andrew","last_name":"Jahoda","domain_name":"independent","page_name":"AndrewJahoda","display_name":"Andrew Jahoda","profile_url":"https://independent.academia.edu/AndrewJahoda?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73685389 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73685389"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73685389, container: ".js-paper-rank-work_73685389", }); 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The aim of the study was to understand the determinants of physical activity and dietary patterns in this population during their final year of school. Qualitative data were generated from 10 interviews with adolescents with mild-moderate intellectual disabilities. Data were analysed using deductive thematic analysis, employing Self-Determination Theory as a theoretical framework. Adolescents\u0026#39; environment and social interactions play a pivotal role in influencing physical activity and dietary patterns. Three themes emerged from the analysis: situatedness, motivation and wider environmental influences. School structure, high self-efficacy and social connectedness facilitate increased physical activity and healthier diet in adolescents with intellectual disabilities. 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Filled columns,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70742827" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Modulation of cellular antigens in chronically infected CEM cells by HTLV-IIIB. 0-propiolactone-treated cells were acetone-fixed and stained with monoclonal antibodies; hence membrane and cytoplasmic antigen is detected. Filled columns, infected; hatched columns, uninfected cells. Similar results were obtained by flow cytometnc analysis of intact cells. in pathogenicity among virus variants between and within HIVinfected individuals and AIDS patients.4</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/70742827" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ad9376b4c558986335dd4ea68dbbbe32" rel="nofollow" data-download="{"attachment_id":80363967,"asset_id":70742827,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/80363967/download_file?st=MTc0MDAzODM5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="82000798" href="https://ku-dk.academia.edu/CKAxelsson">CK Axelsson</a><script data-card-contents-for-user="82000798" type="text/json">{"id":82000798,"first_name":"CK","last_name":"Axelsson","domain_name":"ku-dk","page_name":"CKAxelsson","display_name":"CK Axelsson","profile_url":"https://ku-dk.academia.edu/CKAxelsson?f_ri=137516","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_70742827 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="70742827"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 70742827, container: ".js-paper-rank-work_70742827", }); 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